SIMILAR PATTERNS OF AMINO ACIDS FOR 2GSS_B_EAAB0_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)


(Deinagkistrodon
acutus)
PF01421
(Reprolysin)
4 VAL A 150
ARG A 187
ILE A  49
TYR A  44
None
0.79A 2gssB-1budA:
undetectable
2gssB-1budA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE


(Rhodococcus sp.)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 PHE A 137
ILE A 106
TYR A 113
GLY A  39
None
None
None
PHE  A 361 (-3.7A)
0.92A 2gssB-1c1dA:
undetectable
2gssB-1c1dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3


(Rattus
norvegicus)
PF06325
(PrmA)
4 TYR A 330
PHE A 334
ILE A 226
TYR A 221
None
None
None
SAH  A 529 (-3.5A)
0.80A 2gssB-1f3lA:
undetectable
2gssB-1f3lA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gsq GLUTATHIONE
S-TRANSFERASE


(Todarodes
pacificus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   7
PHE A   8
ARG A  13
TRP A  38
None
GDN  A 203 (-4.5A)
GDN  A 203 (-4.9A)
GDN  A 203 (-4.1A)
0.60A 2gssB-1gsqA:
25.7
2gssB-1gsqA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE


(Saccharomyces
cerevisiae)
PF00719
(Pyrophosphatase)
4 TYR A  15
VAL A  17
ILE A  49
GLY A 132
None
0.95A 2gssB-1hujA:
undetectable
2gssB-1hujA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 PHE A 111
VAL A 159
ILE A 182
GLY A 143
None
0.92A 2gssB-1jscA:
undetectable
2gssB-1jscA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
4 TYR A 115
PHE A  70
ILE A 199
GLY A 175
None
0.75A 2gssB-1kgpA:
undetectable
2gssB-1kgpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA


(Thermotoga
maritima)
PF13365
(Trypsin_2)
4 PHE A  84
VAL A  40
ILE A 158
GLY A 161
None
0.95A 2gssB-1l1jA:
undetectable
2gssB-1l1jA:
24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
7 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
ILE A 104
TYR A 108
None
GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.7A)
GSH  A 504 (-3.9A)
None
None
0.67A 2gssB-1lbkA:
36.3
2gssB-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A  54
PHE A  55
TRP A  85
TYR A 153
GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
GSH  A 500 (-3.6A)
None
0.85A 2gssB-1m0uA:
23.1
2gssB-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A  54
PHE A  55
VAL A  57
TRP A  85
GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
0.43A 2gssB-1m0uA:
23.1
2gssB-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE


(Rattus
norvegicus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
0.64A 2gssB-1pd21:
24.0
2gssB-1pd21:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE


(Geobacillus
stearothermophilus)
PF06964
(Alpha-L-AF_C)
4 VAL A 413
ILE A  23
TYR A  24
GLY A 383
None
0.76A 2gssB-1pz3A:
undetectable
2gssB-1pz3A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qc5 PROTEIN (ALPHA1
BETA1 INTEGRIN)


(Homo sapiens)
PF00092
(VWA)
4 VAL B 338
ARG B 466
ILE B 456
GLY B 415
None
0.95A 2gssB-1qc5B:
undetectable
2gssB-1qc5B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)


(Salmonella
enterica)
PF00268
(Ribonuc_red_sm)
4 TYR A 105
PHE A  60
ILE A 189
GLY A 165
None
0.84A 2gssB-1r2fA:
undetectable
2gssB-1r2fA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfj 3-DEHYDROQUINATE
DEHYDRATASE


(Staphylococcus
aureus)
PF01487
(DHquinase_I)
4 VAL A   4
ARG A 202
ILE A 192
GLY A 210
None
DHK  A 239 (-2.6A)
DHK  A 239 ( 4.2A)
None
0.93A 2gssB-1sfjA:
undetectable
2gssB-1sfjA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tu7 GLUTATHIONE
S-TRANSFERASE 2


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   7
PHE A   8
TYR A 106
GLY A 204
None
GSH  A1001 (-4.8A)
None
None
0.47A 2gssB-1tu7A:
30.9
2gssB-1tu7A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA


(Schistosoma
mansoni)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A  10
PHE A  11
ARG A  16
TRP A  41
None
None
GSH  A 301 (-4.2A)
GSH  A 301 (-4.0A)
0.90A 2gssB-1u3iA:
23.6
2gssB-1u3iA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
4 TYR A 110
PHE A  65
ILE A 194
GLY A 170
None
0.80A 2gssB-1uzrA:
undetectable
2gssB-1uzrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   8
PHE A   9
ARG A  14
TRP A  39
None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
0.68A 2gssB-1v40A:
24.5
2gssB-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE


(Pyrobaculum
aerophilum)
PF09171
(AGOG)
4 PHE A  76
VAL A  38
ILE A 148
GLY A  47
None
0.88A 2gssB-1xqpA:
undetectable
2gssB-1xqpA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8q U8 SNORNA-BINDING
PROTEIN X29


(Xenopus laevis)
PF00293
(NUDIX)
5 PHE A 172
ARG A 156
ILE A  54
TYR A 160
GLY A 168
None
1.34A 2gssB-2a8qA:
undetectable
2gssB-2a8qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus)
PF00092
(VWA)
4 VAL A 152
ARG A 280
ILE A 270
GLY A 229
None
0.89A 2gssB-2b2xA:
undetectable
2gssB-2b2xA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE


(Sus scrofa)
PF02798
(GST_N)
PF14497
(GST_C_3)
7 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-4.0A)
GTS  A 208 (-3.9A)
None
None
0.21A 2gssB-2gsrA:
35.6
2gssB-2gsrA:
82.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae)
PF00480
(ROK)
4 TYR A  78
VAL A  76
ILE A  30
GLY A   9
None
0.85A 2gssB-2gupA:
undetectable
2gssB-2gupA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
0.69A 2gssB-2hnlA:
25.4
2gssB-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE


(Streptomyces
clavuligerus)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 TYR A 561
PHE A 412
ILE A 460
GLY A 411
TPP  A 600 ( 4.2A)
None
None
TPP  A 600 (-3.6A)
0.92A 2gssB-2ihtA:
undetectable
2gssB-2ihtA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il5 HYPOTHETICAL PROTEIN

(Staphylococcus
aureus)
PF08327
(AHSA1)
4 TYR A  78
VAL A  54
TRP A  30
ILE A  50
None
0.94A 2gssB-2il5A:
undetectable
2gssB-2il5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti)
PF00881
(Nitroreductase)
4 ARG A  72
TRP A 189
ILE A  47
GLY A 193
None
0.72A 2gssB-2isjA:
undetectable
2gssB-2isjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE


(Vibrio cholerae)
PF03167
(UDG)
5 TYR A  66
VAL A  79
ILE A  92
TYR A  93
GLY A 109
None
1.04A 2gssB-2jhqA:
undetectable
2gssB-2jhqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lj8 COFILIN/ACTIN
DEPOLYMERIZING
FACTOR, PUTATIVE


(Trypanosoma
brucei)
PF00241
(Cofilin_ADF)
4 PHE A  57
ILE A  36
TYR A  34
GLY A  54
None
0.89A 2gssB-2lj8A:
undetectable
2gssB-2lj8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT


(Bacillus sp. D6)
PF09491
(RE_AlwI)
4 TYR A   8
VAL A 135
ILE A  72
GLY A 110
None
0.89A 2gssB-2p14A:
undetectable
2gssB-2p14A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE


(Aquifex
aeolicus)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
4 TYR A  51
ILE A 212
TYR A 215
GLY A 243
None
0.90A 2gssB-2p3eA:
undetectable
2gssB-2p3eA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE


(Thermus
thermophilus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 VAL A 102
ARG A  64
ILE A  10
GLY A  47
None
0.92A 2gssB-2zc8A:
undetectable
2gssB-2zc8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c26 PUTATIVE
ACETYLTRANSFERASE
TA0821


(Thermoplasma
acidophilum)
PF00583
(Acetyltransf_1)
4 VAL A  63
ARG A  90
ILE A  52
GLY A  10
None
NO3  A 266 (-3.9A)
None
None
0.95A 2gssB-3c26A:
undetectable
2gssB-3c26A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM


(Lactococcus
lactis)
PF03610
(EIIA-man)
4 PHE C  88
VAL C  90
ILE C   7
GLY C  95
None
0.92A 2gssB-3cr3C:
undetectable
2gssB-3cr3C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE


(Leishmania
naiffi)
PF03167
(UDG)
5 TYR A 208
VAL A 221
ILE A 234
TYR A 235
GLY A 251
URB  A 401 ( 3.3A)
None
None
None
None
1.04A 2gssB-3cxmA:
undetectable
2gssB-3cxmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE


(Burkholderia
pseudomallei)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 TYR A 373
VAL A 369
ILE A 210
GLY A 215
None
0.77A 2gssB-3d6bA:
2.1
2gssB-3d6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1


(Oryza sativa)
PF07859
(Abhydrolase_3)
4 TYR A  31
ILE A 133
TYR A 134
GLY A 121
MPD  A 501 ( 4.9A)
None
GA4  A 401 (-4.8A)
GA4  A 401 ( 4.6A)
0.93A 2gssB-3eblA:
undetectable
2gssB-3eblA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Clostridium
acetobutylicum)
PF00155
(Aminotran_1_2)
4 PHE A 186
ILE A  91
TYR A 111
GLY A 151
None
0.80A 2gssB-3ftbA:
undetectable
2gssB-3ftbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5


(Schizosaccharomyces
pombe)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N)
4 VAL C 236
TRP C 171
ILE J   5
GLY J  11
None
0.66A 2gssB-3h0gC:
undetectable
2gssB-3h0gC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2t BASEPLATE STRUCTURAL
PROTEIN GP6


(Escherichia
virus T4)
no annotation 4 PHE A 517
VAL A 538
ILE A 592
GLY A 556
None
0.85A 2gssB-3h2tA:
undetectable
2gssB-3h2tA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i83 2-DEHYDROPANTOATE
2-REDUCTASE


(Methylococcus
capsulatus)
PF02558
(ApbA)
PF08546
(ApbA_C)
4 PHE A 127
ILE A  11
TYR A  15
GLY A 144
None
0.86A 2gssB-3i83A:
undetectable
2gssB-3i83A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis)
PF00923
(TAL_FSA)
4 TYR A 217
PHE A 222
ILE A 143
GLY A 174
None
0.63A 2gssB-3igxA:
undetectable
2gssB-3igxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER


(Porphyromonas
gingivalis)
PF12704
(MacB_PCD)
4 TYR A 262
VAL A  84
ILE A 216
GLY A  82
None
0.94A 2gssB-3is6A:
undetectable
2gssB-3is6A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isl PURINE CATABOLISM
PROTEIN PUCG


(Bacillus
subtilis)
PF00266
(Aminotran_5)
4 PHE A  99
VAL A 145
ILE A 106
GLY A 100
PLP  A 419 (-3.5A)
None
None
None
0.85A 2gssB-3islA:
undetectable
2gssB-3islA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kc2 UNCHARACTERIZED
PROTEIN YKR070W


(Saccharomyces
cerevisiae)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 TYR A 111
VAL A 107
ILE A  79
GLY A  56
None
0.84A 2gssB-3kc2A:
undetectable
2gssB-3kc2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE


(Yersinia pestis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 PHE A 250
ARG A 237
TYR A 247
GLY A 277
None
0.88A 2gssB-3kuxA:
undetectable
2gssB-3kuxA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
4 PHE A 337
VAL A 334
ILE A 404
GLY A 398
None
0.91A 2gssB-3lmkA:
undetectable
2gssB-3lmkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica)
PF00923
(TAL_FSA)
4 TYR A 220
PHE A 225
ILE A 147
GLY A 178
None
0.76A 2gssB-3m16A:
undetectable
2gssB-3m16A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
4 TYR A 115
PHE A  70
ILE A 199
GLY A 175
None
0.82A 2gssB-3mjoA:
undetectable
2gssB-3mjoA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE


(Ruegeria sp.
TM1040)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
4 VAL A 360
TRP A 193
ILE A 183
GLY A 187
None
0.88A 2gssB-3n0qA:
undetectable
2gssB-3n0qA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA


(Escherichia
coli)
no annotation 4 TYR B 105
PHE B  60
ILE B 189
GLY B 165
None
0.94A 2gssB-3n3bB:
undetectable
2gssB-3n3bB:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1


(Mus musculus)
PF02798
(GST_N)
PF14497
(GST_C_3)
7 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
TYR A 108
GLY A 205
None
GTB  A 210 (-4.5A)
None
GTB  A 210 (-3.9A)
GTB  A 210 (-4.0A)
GTB  A 210 (-4.1A)
GTB  A 210 (-3.7A)
0.40A 2gssB-3o76A:
36.5
2gssB-3o76A:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE


(Aliivibrio
fischeri)
PF02719
(Polysacc_synt_2)
4 TYR A 157
VAL A 113
ILE A  95
TYR A 100
None
None
NAD  A 501 (-3.9A)
None
0.84A 2gssB-3pvzA:
undetectable
2gssB-3pvzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides)
PF01370
(Epimerase)
4 VAL A  24
TRP A  19
ILE A 125
GLY A  45
None
0.91A 2gssB-3rucA:
undetectable
2gssB-3rucA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
4 PHE A 152
VAL A 144
ILE A 138
GLY A 155
None
0.74A 2gssB-3sh5A:
undetectable
2gssB-3sh5A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t90 GLUCOSE-6-PHOSPHATE
ACETYLTRANSFERASE 1


(Arabidopsis
thaliana)
PF00583
(Acetyltransf_1)
4 PHE A 107
VAL A 104
ILE A  64
GLY A  68
None
0.86A 2gssB-3t90A:
undetectable
2gssB-3t90A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger)
PF00445
(Ribonuclease_T2)
4 TYR A 237
VAL A 228
ILE A 145
GLY A 230
None
0.88A 2gssB-3tbjA:
undetectable
2gssB-3tbjA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE


(Coxiella
burnetii)
PF03167
(UDG)
4 TYR A  69
VAL A  82
ILE A  95
GLY A 111
None
0.88A 2gssB-3tr7A:
undetectable
2gssB-3tr7A:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA


(Bombyx mori)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   8
PHE A   9
VAL A  11
TRP A  39
GSH  A 301 (-4.3A)
GSH  A 301 (-4.3A)
None
GSH  A 301 (-3.5A)
0.40A 2gssB-3vpqA:
20.5
2gssB-3vpqA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 VAL A 592
ILE A 267
TYR A 225
GLY A 569
None
0.88A 2gssB-3wdjA:
undetectable
2gssB-3wdjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
4 PHE A 476
TRP A 432
TYR A 438
GLY A 429
None
ACR  A1001 ( 4.6A)
None
None
0.92A 2gssB-3welA:
undetectable
2gssB-3welA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zoq URACIL-DNA
GLYCOSYLASE


(Bacillus
subtilis)
PF03167
(UDG)
4 TYR A  67
VAL A  80
ILE A  93
GLY A 109
None
0.94A 2gssB-3zoqA:
undetectable
2gssB-3zoqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
4 PHE A 539
ILE A 254
TYR A 506
GLY A 537
None
0.80A 2gssB-4aioA:
undetectable
2gssB-4aioA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni)
no annotation 4 PHE A  27
VAL A  29
TYR A  67
GLY A  65
None
0.76A 2gssB-4bg2A:
undetectable
2gssB-4bg2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni)
no annotation 4 VAL A  29
ARG A  21
TYR A  67
GLY A  65
None
0.95A 2gssB-4bg2A:
undetectable
2gssB-4bg2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwr PROTEIN
CORRESPONDING TO
LOCUS C5321 FROM
CFT073 E.COLI STRAIN


(Escherichia
coli)
PF08238
(Sel1)
4 PHE A 414
VAL A 380
ILE A 421
GLY A 415
EDO  A1490 (-4.7A)
None
EDO  A1477 (-3.3A)
None
0.93A 2gssB-4bwrA:
undetectable
2gssB-4bwrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE


(Thermotoga
maritima)
PF13597
(NRDD)
4 TYR A 227
ILE A 555
TYR A 584
GLY A 361
None
0.90A 2gssB-4conA:
undetectable
2gssB-4conA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN


(Parabacteroides
merdae)
PF06283
(ThuA)
4 PHE A 289
VAL A 285
TRP A 192
GLY A 187
None
None
None
EDO  A 407 ( 4.7A)
0.93A 2gssB-4e5vA:
undetectable
2gssB-4e5vA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN


(Bacteroides
thetaiotaomicron)
PF14660
(DUF4458)
4 PHE A 394
ARG A 412
ILE A 580
TYR A 582
None
0.92A 2gssB-4ecnA:
undetectable
2gssB-4ecnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqj HEMAGGLUTININ

(Influenza B
virus)
PF00509
(Hemagglutinin)
4 TYR A 202
VAL A 160
ILE A 243
GLY A 138
None
0.95A 2gssB-4fqjA:
undetectable
2gssB-4fqjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE


(Mycolicibacterium
thermoresistibile)
PF16113
(ECH_2)
4 TYR A  92
VAL A 148
ILE A  73
GLY A 116
None
0.82A 2gssB-4hdtA:
undetectable
2gssB-4hdtA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN


(Pseudomonas)
PF01804
(Penicil_amidase)
4 TYR B  32
PHE B  31
VAL B  49
ILE B 176
GLJ  B 601 (-4.9A)
None
None
None
0.88A 2gssB-4hstB:
undetectable
2gssB-4hstB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE


(Gadus morhua)
PF03167
(UDG)
4 TYR A 147
VAL A 160
ILE A 173
GLY A 190
None
0.94A 2gssB-4lylA:
undetectable
2gssB-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Streptococcus
sanguinis)
PF00268
(Ribonuc_red_sm)
4 TYR A 104
PHE A  59
ILE A 188
GLY A 164
None
0.86A 2gssB-4n83A:
undetectable
2gssB-4n83A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 ARG A 266
ILE A 300
TYR A 295
GLY A 427
None
0.93A 2gssB-4na3A:
undetectable
2gssB-4na3A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Geobacter
sulfurreducens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
4 VAL A 938
ARG A 933
ILE A 943
GLY A 919
EDO  A1104 (-4.7A)
None
None
None
0.91A 2gssB-4nmeA:
undetectable
2gssB-4nmeA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE


(Rhodotorula
mucilaginosa)
PF13561
(adh_short_C2)
4 PHE A  76
VAL A  78
ILE A  33
GLY A  53
None
0.89A 2gssB-4o0lA:
undetectable
2gssB-4o0lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE


(Geobacillus
stearothermophilus)
PF00331
(Glyco_hydro_10)
4 PHE A 360
ILE A 284
TYR A 281
GLY A 363
None
0.74A 2gssB-4pueA:
undetectable
2gssB-4pueA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3m 2-DEHYDROPANTOATE
2-REDUCTASE


(Staphylococcus
aureus)
PF02558
(ApbA)
PF08546
(ApbA_C)
4 TYR A  40
VAL A 126
ILE A 117
GLY A  11
None
None
None
NAP  A 500 (-3.1A)
0.80A 2gssB-4s3mA:
undetectable
2gssB-4s3mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA


(Bacillus
subtilis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 VAL A  23
ILE A  31
TYR A 125
GLY A  48
None
0.92A 2gssB-4tr6A:
undetectable
2gssB-4tr6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE


(Deinococcus
radiodurans)
PF03167
(UDG)
5 TYR A  85
VAL A  98
ILE A 111
TYR A 112
GLY A 128
CL  A1245 (-4.3A)
None
None
None
None
1.10A 2gssB-4uqmA:
undetectable
2gssB-4uqmA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN


(Haliangium
ochraceum)
PF14497
(GST_C_3)
4 TYR A   9
PHE A  10
VAL A  12
TRP A  40
None
0.30A 2gssB-4w66A:
21.5
2gssB-4w66A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens)
PF00107
(ADH_zinc_N)
4 PHE A1831
VAL A1854
ILE A1544
GLY A1833
None
0.93A 2gssB-4w82A:
undetectable
2gssB-4w82A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1e PECTINESTERASE

(Aspergillus
niger)
PF01095
(Pectinesterase)
4 TYR A  73
VAL A 102
TYR A  67
GLY A  89
None
0.91A 2gssB-5c1eA:
undetectable
2gssB-5c1eA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d73 GLUTATHIONE
S-TRANSFERASE


(Wuchereria
bancrofti)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   7
PHE A   8
TYR A 106
GLY A 204
None
GSH  A 301 (-4.9A)
None
None
0.48A 2gssB-5d73A:
31.0
2gssB-5d73A:
42.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis GTP-BINDING NUCLEAR
PROTEIN RAN


(Homo sapiens)
PF00071
(Ras)
4 TYR B 155
VAL B 124
TYR B 146
GLY B 121
None
0.93A 2gssB-5disB:
undetectable
2gssB-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1)
PF12226
(Astro_capsid_p)
4 TYR A 588
PHE A 582
VAL A 543
GLY A 546
None
0.90A 2gssB-5ewoA:
undetectable
2gssB-5ewoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5


(Saccharomyces
cerevisiae)
PF12717
(Cnd1)
4 TYR A 157
VAL A 219
ILE A 179
GLY A 172
None
0.86A 2gssB-5frsA:
undetectable
2gssB-5frsA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 TYR B 859
VAL B 968
ARG B 942
GLY B 947
None
0.85A 2gssB-5ip9B:
undetectable
2gssB-5ip9B:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
4 TYR B 196
PHE B  76
ILE B 249
GLY B  80
None
0.81A 2gssB-5kohB:
undetectable
2gssB-5kohB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x55 PROBABLE URACIL-DNA
GLYCOSYLASE


(Acanthamoeba
polyphaga
mimivirus)
PF03167
(UDG)
4 TYR A 193
VAL A 211
ILE A 224
GLY A 241
None
0.81A 2gssB-5x55A:
undetectable
2gssB-5x55A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Colwellia
psychrerythraea)
PF00275
(EPSP_synthase)
4 PHE A 250
VAL A 261
ILE A   9
GLY A 254
None
0.86A 2gssB-5xwbA:
undetectable
2gssB-5xwbA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650


(Bacillus
subtilis)
no annotation 4 TYR A  72
PHE A  41
VAL A  76
GLY A  45
None
0.85A 2gssB-5y0qA:
undetectable
2gssB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Streptococcus
agalactiae)
no annotation 4 VAL A 123
ILE A  17
TYR A 324
GLY A 153
None
NAD  A 401 (-4.3A)
NAD  A 401 (-3.6A)
None
0.94A 2gssB-5y37A:
undetectable
2gssB-5y37A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k DRAXIN
NETRIN RECEPTOR DCC


(Rattus
norvegicus)
no annotation 4 ARG B 282
ILE A 387
TYR A 398
GLY A 396
None
0.94A 2gssB-5z5kB:
undetectable
2gssB-5z5kB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA


(Acinetobacter
baumannii)
no annotation 4 VAL A  21
ILE A  29
TYR A 119
GLY A  46
None
0.93A 2gssB-6ap4A:
undetectable
2gssB-6ap4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d79 SULFATE TRANSPORTER
CYSZ


(Pseudomonas
fragi)
no annotation 4 VAL A 172
TRP A 203
ILE A 180
GLY A 210
None
0.95A 2gssB-6d79A:
undetectable
2gssB-6d79A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3


(Rattus rattus)
PF00043
(GST_C)
PF02798
(GST_N)
4 TYR A   6
VAL A   9
ILE A 111
TYR A 115
None
None
GPS  A 221 (-4.5A)
None
0.91A 2gssB-6gswA:
25.8
2gssB-6gswA:
29.86