SIMILAR PATTERNS OF AMINO ACIDS FOR 2GSS_B_EAAB0_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bud | PROTEIN (ACUTOLYSINA) (Deinagkistrodonacutus) |
PF01421(Reprolysin) | 4 | VAL A 150ARG A 187ILE A 49TYR A 44 | None | 0.79A | 2gssB-1budA:undetectable | 2gssB-1budA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c1d | L-PHENYLALANINEDEHYDROGENASE (Rhodococcus sp.) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | PHE A 137ILE A 106TYR A 113GLY A 39 | NoneNoneNonePHE A 361 (-3.7A) | 0.92A | 2gssB-1c1dA:undetectable | 2gssB-1c1dA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f3l | PROTEIN ARGININEMETHYLTRANSFERASEPRMT3 (Rattusnorvegicus) |
PF06325(PrmA) | 4 | TYR A 330PHE A 334ILE A 226TYR A 221 | NoneNoneNoneSAH A 529 (-3.5A) | 0.80A | 2gssB-1f3lA:undetectable | 2gssB-1f3lA:19.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gsq | GLUTATHIONES-TRANSFERASE (Todarodespacificus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 7PHE A 8ARG A 13TRP A 38 | NoneGDN A 203 (-4.5A)GDN A 203 (-4.9A)GDN A 203 (-4.1A) | 0.60A | 2gssB-1gsqA:25.7 | 2gssB-1gsqA:32.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1huj | INORGANICPYROPHOSPHATASE (Saccharomycescerevisiae) |
PF00719(Pyrophosphatase) | 4 | TYR A 15VAL A 17ILE A 49GLY A 132 | None | 0.95A | 2gssB-1hujA:undetectable | 2gssB-1hujA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsc | ACETOHYDROXY-ACIDSYNTHASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | PHE A 111VAL A 159ILE A 182GLY A 143 | None | 0.92A | 2gssB-1jscA:undetectable | 2gssB-1jscA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kgp | RIBONUCLEOTIDEREDUCTASE PROTEINR2F (Corynebacteriumammoniagenes) |
PF00268(Ribonuc_red_sm) | 4 | TYR A 115PHE A 70ILE A 199GLY A 175 | None | 0.75A | 2gssB-1kgpA:undetectable | 2gssB-1kgpA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1j | HEAT SHOCK PROTEASEHTRA (Thermotogamaritima) |
PF13365(Trypsin_2) | 4 | PHE A 84VAL A 40ILE A 158GLY A 161 | None | 0.95A | 2gssB-1l1jA:undetectable | 2gssB-1l1jA:24.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lbk | GLUTATHIONES-TRANSFERASE CLASSPI CHIMAERA (CODA) (Homo sapiens) |
PF02798(GST_N)PF14497(GST_C_3) | 7 | TYR A 7PHE A 8VAL A 10ARG A 13TRP A 38ILE A 104TYR A 108 | NoneGSH A 504 (-4.7A)NoneGSH A 504 (-3.7A)GSH A 504 (-3.9A)NoneNone | 0.67A | 2gssB-1lbkA:36.3 | 2gssB-1lbkA:97.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m0u | GST2 GENE PRODUCT (Drosophilamelanogaster) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 54PHE A 55TRP A 85TYR A 153 | GSH A 500 (-4.7A)GSH A 500 (-4.8A)GSH A 500 (-3.6A)None | 0.85A | 2gssB-1m0uA:23.1 | 2gssB-1m0uA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m0u | GST2 GENE PRODUCT (Drosophilamelanogaster) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 54PHE A 55VAL A 57TRP A 85 | GSH A 500 (-4.7A)GSH A 500 (-4.8A)NoneGSH A 500 (-3.6A) | 0.43A | 2gssB-1m0uA:23.1 | 2gssB-1m0uA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pd2 | HEMATOPOIETICPROSTAGLANDIN DSYNTHASE (Rattusnorvegicus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR 1 8PHE 1 9ARG 1 14TRP 1 39 | GSH 1 301 (-4.8A)NoneGSH 1 301 (-3.4A)GSH 1 301 (-3.6A) | 0.64A | 2gssB-1pd21:24.0 | 2gssB-1pd21:28.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pz3 | ALPHA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF06964(Alpha-L-AF_C) | 4 | VAL A 413ILE A 23TYR A 24GLY A 383 | None | 0.76A | 2gssB-1pz3A:undetectable | 2gssB-1pz3A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qc5 | PROTEIN (ALPHA1BETA1 INTEGRIN) (Homo sapiens) |
PF00092(VWA) | 4 | VAL B 338ARG B 466ILE B 456GLY B 415 | None | 0.95A | 2gssB-1qc5B:undetectable | 2gssB-1qc5B:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r2f | PROTEIN(RIBONUCLEOTIDEREDUCTASE R2) (Salmonellaenterica) |
PF00268(Ribonuc_red_sm) | 4 | TYR A 105PHE A 60ILE A 189GLY A 165 | None | 0.84A | 2gssB-1r2fA:undetectable | 2gssB-1r2fA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfj | 3-DEHYDROQUINATEDEHYDRATASE (Staphylococcusaureus) |
PF01487(DHquinase_I) | 4 | VAL A 4ARG A 202ILE A 192GLY A 210 | NoneDHK A 239 (-2.6A)DHK A 239 ( 4.2A)None | 0.93A | 2gssB-1sfjA:undetectable | 2gssB-1sfjA:21.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tu7 | GLUTATHIONES-TRANSFERASE 2 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 7PHE A 8TYR A 106GLY A 204 | NoneGSH A1001 (-4.8A)NoneNone | 0.47A | 2gssB-1tu7A:30.9 | 2gssB-1tu7A:41.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3i | GLUTATHIONES-TRANSFERASE 28 KDA (Schistosomamansoni) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 10PHE A 11ARG A 16TRP A 41 | NoneNoneGSH A 301 (-4.2A)GSH A 301 (-4.0A) | 0.90A | 2gssB-1u3iA:23.6 | 2gssB-1u3iA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzr | RIBONUCLEOTIDEREDUCTASE R2-2 SMALLSUBUNIT (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 4 | TYR A 110PHE A 65ILE A 194GLY A 170 | None | 0.80A | 2gssB-1uzrA:undetectable | 2gssB-1uzrA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v40 | GLUTATHIONE-REQUIRING PROSTAGLANDIN DSYNTHASE (Homo sapiens) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 8PHE A 9ARG A 14TRP A 39 | NoneO16 A3201 (-3.0A)O16 A3201 ( 3.8A)GSH A3200 (-4.1A) | 0.68A | 2gssB-1v40A:24.5 | 2gssB-1v40A:27.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xqp | 8-OXOGUANINE DNAGLYCOSYLASE (Pyrobaculumaerophilum) |
PF09171(AGOG) | 4 | PHE A 76VAL A 38ILE A 148GLY A 47 | None | 0.88A | 2gssB-1xqpA:undetectable | 2gssB-1xqpA:24.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a8q | U8 SNORNA-BINDINGPROTEIN X29 (Xenopus laevis) |
PF00293(NUDIX) | 5 | PHE A 172ARG A 156ILE A 54TYR A 160GLY A 168 | None | 1.34A | 2gssB-2a8qA:undetectable | 2gssB-2a8qA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2x | INTEGRIN ALPHA-1 (Rattusnorvegicus) |
PF00092(VWA) | 4 | VAL A 152ARG A 280ILE A 270GLY A 229 | None | 0.89A | 2gssB-2b2xA:undetectable | 2gssB-2b2xA:23.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gsr | CLASS PI GSTGLUTATHIONES-TRANSFERASE (Sus scrofa) |
PF02798(GST_N)PF14497(GST_C_3) | 7 | TYR A 7PHE A 8VAL A 10ARG A 13TRP A 38TYR A 106GLY A 203 | GTS A 208 (-4.5A)GTS A 208 (-4.7A)NoneGTS A 208 (-4.0A)GTS A 208 (-3.9A)NoneNone | 0.21A | 2gssB-2gsrA:35.6 | 2gssB-2gsrA:82.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gup | ROK FAMILY PROTEIN (Streptococcuspneumoniae) |
PF00480(ROK) | 4 | TYR A 78VAL A 76ILE A 30GLY A 9 | None | 0.85A | 2gssB-2gupA:undetectable | 2gssB-2gupA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnl | GLUTATHIONES-TRANSFERASE 1 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | TYR A 32PHE A 33ARG A 38TRP A 63ILE A 127 | NoneNoneGSH A 501 (-4.3A)GSH A 501 (-3.9A)None | 0.69A | 2gssB-2hnlA:25.4 | 2gssB-2hnlA:27.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iht | CARBOXYETHYLARGININESYNTHASE (Streptomycesclavuligerus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | TYR A 561PHE A 412ILE A 460GLY A 411 | TPP A 600 ( 4.2A)NoneNoneTPP A 600 (-3.6A) | 0.92A | 2gssB-2ihtA:undetectable | 2gssB-2ihtA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2il5 | HYPOTHETICAL PROTEIN (Staphylococcusaureus) |
PF08327(AHSA1) | 4 | TYR A 78VAL A 54TRP A 30ILE A 50 | None | 0.94A | 2gssB-2il5A:undetectable | 2gssB-2il5A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isj | BLUB (Sinorhizobiummeliloti) |
PF00881(Nitroreductase) | 4 | ARG A 72TRP A 189ILE A 47GLY A 193 | None | 0.72A | 2gssB-2isjA:undetectable | 2gssB-2isjA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jhq | URACILDNA-GLYCOSYLASE (Vibrio cholerae) |
PF03167(UDG) | 5 | TYR A 66VAL A 79ILE A 92TYR A 93GLY A 109 | None | 1.04A | 2gssB-2jhqA:undetectable | 2gssB-2jhqA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lj8 | COFILIN/ACTINDEPOLYMERIZINGFACTOR, PUTATIVE (Trypanosomabrucei) |
PF00241(Cofilin_ADF) | 4 | PHE A 57ILE A 36TYR A 34GLY A 54 | None | 0.89A | 2gssB-2lj8A:undetectable | 2gssB-2lj8A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p14 | HETERODIMERICRESTRICTIONENDONUCLEASER.BSPD6I SMALLSUBUNIT (Bacillus sp. D6) |
PF09491(RE_AlwI) | 4 | TYR A 8VAL A 135ILE A 72GLY A 110 | None | 0.89A | 2gssB-2p14A:undetectable | 2gssB-2p14A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3e | DIAMINOPIMELATEDECARBOXYLASE (Aquifexaeolicus) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 4 | TYR A 51ILE A 212TYR A 215GLY A 243 | None | 0.90A | 2gssB-2p3eA:undetectable | 2gssB-2p3eA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zc8 | N-ACYLAMINO ACIDRACEMASE (Thermusthermophilus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | VAL A 102ARG A 64ILE A 10GLY A 47 | None | 0.92A | 2gssB-2zc8A:undetectable | 2gssB-2zc8A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c26 | PUTATIVEACETYLTRANSFERASETA0821 (Thermoplasmaacidophilum) |
PF00583(Acetyltransf_1) | 4 | VAL A 63ARG A 90ILE A 52GLY A 10 | NoneNO3 A 266 (-3.9A)NoneNone | 0.95A | 2gssB-3c26A:undetectable | 2gssB-3c26A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cr3 | PTS-DEPENDENTDIHYDROXYACETONEKINASE,PHOSPHOTRANSFERASESUBUNIT DHAM (Lactococcuslactis) |
PF03610(EIIA-man) | 4 | PHE C 88VAL C 90ILE C 7GLY C 95 | None | 0.92A | 2gssB-3cr3C:undetectable | 2gssB-3cr3C:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cxm | URACIL-DNAGLYCOSYLASE (Leishmanianaiffi) |
PF03167(UDG) | 5 | TYR A 208VAL A 221ILE A 234TYR A 235GLY A 251 | URB A 401 ( 3.3A)NoneNoneNoneNone | 1.04A | 2gssB-3cxmA:undetectable | 2gssB-3cxmA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6b | GLUTARYL-COADEHYDROGENASE (Burkholderiapseudomallei) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | TYR A 373VAL A 369ILE A 210GLY A 215 | None | 0.77A | 2gssB-3d6bA:2.1 | 2gssB-3d6bA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebl | GIBBERELLIN RECEPTORGID1 (Oryza sativa) |
PF07859(Abhydrolase_3) | 4 | TYR A 31ILE A 133TYR A 134GLY A 121 | MPD A 501 ( 4.9A)NoneGA4 A 401 (-4.8A)GA4 A 401 ( 4.6A) | 0.93A | 2gssB-3eblA:undetectable | 2gssB-3eblA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ftb | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Clostridiumacetobutylicum) |
PF00155(Aminotran_1_2) | 4 | PHE A 186ILE A 91TYR A 111GLY A 151 | None | 0.80A | 2gssB-3ftbA:undetectable | 2gssB-3ftbA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB3DNA-DIRECTED RNAPOLYMERASES I, II,AND III SUBUNITRPABC5 (Schizosaccharomycespombe) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L)PF01194(RNA_pol_N) | 4 | VAL C 236TRP C 171ILE J 5GLY J 11 | None | 0.66A | 2gssB-3h0gC:undetectable | 2gssB-3h0gC:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2t | BASEPLATE STRUCTURALPROTEIN GP6 (Escherichiavirus T4) |
no annotation | 4 | PHE A 517VAL A 538ILE A 592GLY A 556 | None | 0.85A | 2gssB-3h2tA:undetectable | 2gssB-3h2tA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i83 | 2-DEHYDROPANTOATE2-REDUCTASE (Methylococcuscapsulatus) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | PHE A 127ILE A 11TYR A 15GLY A 144 | None | 0.86A | 2gssB-3i83A:undetectable | 2gssB-3i83A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igx | TRANSALDOLASE (Francisellatularensis) |
PF00923(TAL_FSA) | 4 | TYR A 217PHE A 222ILE A 143GLY A 174 | None | 0.63A | 2gssB-3igxA:undetectable | 2gssB-3igxA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3is6 | PUTATIVE PERMEASEPROTEIN, ABCTRANSPORTER (Porphyromonasgingivalis) |
PF12704(MacB_PCD) | 4 | TYR A 262VAL A 84ILE A 216GLY A 82 | None | 0.94A | 2gssB-3is6A:undetectable | 2gssB-3is6A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3isl | PURINE CATABOLISMPROTEIN PUCG (Bacillussubtilis) |
PF00266(Aminotran_5) | 4 | PHE A 99VAL A 145ILE A 106GLY A 100 | PLP A 419 (-3.5A)NoneNoneNone | 0.85A | 2gssB-3islA:undetectable | 2gssB-3islA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kc2 | UNCHARACTERIZEDPROTEIN YKR070W (Saccharomycescerevisiae) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | TYR A 111VAL A 107ILE A 79GLY A 56 | None | 0.84A | 2gssB-3kc2A:undetectable | 2gssB-3kc2A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kux | PUTATIVEOXIDOREDUCTASE (Yersinia pestis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | PHE A 250ARG A 237TYR A 247GLY A 277 | None | 0.88A | 2gssB-3kuxA:undetectable | 2gssB-3kuxA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmk | METABOTROPICGLUTAMATE RECEPTOR 5 (Homo sapiens) |
PF01094(ANF_receptor) | 4 | PHE A 337VAL A 334ILE A 404GLY A 398 | None | 0.91A | 2gssB-3lmkA:undetectable | 2gssB-3lmkA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m16 | TRANSALDOLASE (Oleispiraantarctica) |
PF00923(TAL_FSA) | 4 | TYR A 220PHE A 225ILE A 147GLY A 178 | None | 0.76A | 2gssB-3m16A:undetectable | 2gssB-3m16A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mjo | RIBONUCLEOTIDEREDUCTASE SUBUNITR2F (Corynebacteriumammoniagenes) |
PF00268(Ribonuc_red_sm) | 4 | TYR A 115PHE A 70ILE A 199GLY A 175 | None | 0.82A | 2gssB-3mjoA:undetectable | 2gssB-3mjoA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0q | PUTATIVEAROMATIC-RINGHYDROXYLATINGDIOXYGENASE (Ruegeria sp.TM1040) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | VAL A 360TRP A 193ILE A 183GLY A 187 | None | 0.88A | 2gssB-3n0qA:undetectable | 2gssB-3n0qA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3b | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2SUBUNIT BETA (Escherichiacoli) |
no annotation | 4 | TYR B 105PHE B 60ILE B 189GLY B 165 | None | 0.94A | 2gssB-3n3bB:undetectable | 2gssB-3n3bB:21.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o76 | GLUTATHIONES-TRANSFERASE P 1 (Mus musculus) |
PF02798(GST_N)PF14497(GST_C_3) | 7 | TYR A 7PHE A 8VAL A 10ARG A 13TRP A 38TYR A 108GLY A 205 | NoneGTB A 210 (-4.5A)NoneGTB A 210 (-3.9A)GTB A 210 (-4.0A)GTB A 210 (-4.1A)GTB A 210 (-3.7A) | 0.40A | 2gssB-3o76A:36.5 | 2gssB-3o76A:84.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvz | UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (Aliivibriofischeri) |
PF02719(Polysacc_synt_2) | 4 | TYR A 157VAL A 113ILE A 95TYR A 100 | NoneNoneNAD A 501 (-3.9A)None | 0.84A | 2gssB-3pvzA:undetectable | 2gssB-3pvzA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ruc | WBGU (Plesiomonasshigelloides) |
PF01370(Epimerase) | 4 | VAL A 24TRP A 19ILE A 125GLY A 45 | None | 0.91A | 2gssB-3rucA:undetectable | 2gssB-3rucA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sh5 | LG3 PEPTIDE (Homo sapiens) |
PF00054(Laminin_G_1) | 4 | PHE A 152VAL A 144ILE A 138GLY A 155 | None | 0.74A | 2gssB-3sh5A:undetectable | 2gssB-3sh5A:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t90 | GLUCOSE-6-PHOSPHATEACETYLTRANSFERASE 1 (Arabidopsisthaliana) |
PF00583(Acetyltransf_1) | 4 | PHE A 107VAL A 104ILE A 64GLY A 68 | None | 0.86A | 2gssB-3t90A:undetectable | 2gssB-3t90A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbj | ACTIBIND (Aspergillusniger) |
PF00445(Ribonuclease_T2) | 4 | TYR A 237VAL A 228ILE A 145GLY A 230 | None | 0.88A | 2gssB-3tbjA:undetectable | 2gssB-3tbjA:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr7 | URACIL-DNAGLYCOSYLASE (Coxiellaburnetii) |
PF03167(UDG) | 4 | TYR A 69VAL A 82ILE A 95GLY A 111 | None | 0.88A | 2gssB-3tr7A:undetectable | 2gssB-3tr7A:22.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vpq | GLUTATHIONES-TRANSFERASE SIGMA (Bombyx mori) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 8PHE A 9VAL A 11TRP A 39 | GSH A 301 (-4.3A)GSH A 301 (-4.3A)NoneGSH A 301 (-3.5A) | 0.40A | 2gssB-3vpqA:20.5 | 2gssB-3vpqA:31.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdj | TYPE I PULLULANASE (Anoxybacillussp. LM18-11) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 4 | VAL A 592ILE A 267TYR A 225GLY A 569 | None | 0.88A | 2gssB-3wdjA:undetectable | 2gssB-3wdjA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wel | ALPHA-GLUCOSIDASE (Beta vulgaris) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 4 | PHE A 476TRP A 432TYR A 438GLY A 429 | NoneACR A1001 ( 4.6A)NoneNone | 0.92A | 2gssB-3welA:undetectable | 2gssB-3welA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zoq | URACIL-DNAGLYCOSYLASE (Bacillussubtilis) |
PF03167(UDG) | 4 | TYR A 67VAL A 80ILE A 93GLY A 109 | None | 0.94A | 2gssB-3zoqA:undetectable | 2gssB-3zoqA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aio | LIMIT DEXTRINASE (Hordeum vulgare) |
PF02922(CBM_48)PF11852(DUF3372) | 4 | PHE A 539ILE A 254TYR A 506GLY A 537 | None | 0.80A | 2gssB-4aioA:undetectable | 2gssB-4aioA:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bg2 | PATF (Prochlorondidemni) |
no annotation | 4 | PHE A 27VAL A 29TYR A 67GLY A 65 | None | 0.76A | 2gssB-4bg2A:undetectable | 2gssB-4bg2A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bg2 | PATF (Prochlorondidemni) |
no annotation | 4 | VAL A 29ARG A 21TYR A 67GLY A 65 | None | 0.95A | 2gssB-4bg2A:undetectable | 2gssB-4bg2A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwr | PROTEINCORRESPONDING TOLOCUS C5321 FROMCFT073 E.COLI STRAIN (Escherichiacoli) |
PF08238(Sel1) | 4 | PHE A 414VAL A 380ILE A 421GLY A 415 | EDO A1490 (-4.7A)NoneEDO A1477 (-3.3A)None | 0.93A | 2gssB-4bwrA:undetectable | 2gssB-4bwrA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4con | ANAEROBICRIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE (Thermotogamaritima) |
PF13597(NRDD) | 4 | TYR A 227ILE A 555TYR A 584GLY A 361 | None | 0.90A | 2gssB-4conA:undetectable | 2gssB-4conA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5v | PUTATIVE THUA-LIKEPROTEIN (Parabacteroidesmerdae) |
PF06283(ThuA) | 4 | PHE A 289VAL A 285TRP A 192GLY A 187 | NoneNoneNoneEDO A 407 ( 4.7A) | 0.93A | 2gssB-4e5vA:undetectable | 2gssB-4e5vA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 4 | PHE A 394ARG A 412ILE A 580TYR A 582 | None | 0.92A | 2gssB-4ecnA:undetectable | 2gssB-4ecnA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqj | HEMAGGLUTININ (Influenza Bvirus) |
PF00509(Hemagglutinin) | 4 | TYR A 202VAL A 160ILE A 243GLY A 138 | None | 0.95A | 2gssB-4fqjA:undetectable | 2gssB-4fqjA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hdt | 3-HYDROXYISOBUTYRYL-COA HYDROLASE (Mycolicibacteriumthermoresistibile) |
PF16113(ECH_2) | 4 | TYR A 92VAL A 148ILE A 73GLY A 116 | None | 0.82A | 2gssB-4hdtA:undetectable | 2gssB-4hdtA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hst | GLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE BETA CHAIN (Pseudomonas) |
PF01804(Penicil_amidase) | 4 | TYR B 32PHE B 31VAL B 49ILE B 176 | GLJ B 601 (-4.9A)NoneNoneNone | 0.88A | 2gssB-4hstB:undetectable | 2gssB-4hstB:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lyl | URACIL-DNAGLYCOSYLASE (Gadus morhua) |
PF03167(UDG) | 4 | TYR A 147VAL A 160ILE A 173GLY A 190 | None | 0.94A | 2gssB-4lylA:undetectable | 2gssB-4lylA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n83 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT BETA (Streptococcussanguinis) |
PF00268(Ribonuc_red_sm) | 4 | TYR A 104PHE A 59ILE A 188GLY A 164 | None | 0.86A | 2gssB-4n83A:undetectable | 2gssB-4n83A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | ARG A 266ILE A 300TYR A 295GLY A 427 | None | 0.93A | 2gssB-4na3A:undetectable | 2gssB-4na3A:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nme | PROLINEDEHYDROGENASE ANDDELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE (Geobactersulfurreducens) |
PF00171(Aldedh)PF01619(Pro_dh) | 4 | VAL A 938ARG A 933ILE A 943GLY A 919 | EDO A1104 (-4.7A)NoneNoneNone | 0.91A | 2gssB-4nmeA:undetectable | 2gssB-4nmeA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o0l | NADPH-DEPENDENT3-QUINUCLIDINONEREDUCTASE (Rhodotorulamucilaginosa) |
PF13561(adh_short_C2) | 4 | PHE A 76VAL A 78ILE A 33GLY A 53 | None | 0.89A | 2gssB-4o0lA:undetectable | 2gssB-4o0lA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pue | ENDO-1,4-BETA-XYLANASE (Geobacillusstearothermophilus) |
PF00331(Glyco_hydro_10) | 4 | PHE A 360ILE A 284TYR A 281GLY A 363 | None | 0.74A | 2gssB-4pueA:undetectable | 2gssB-4pueA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3m | 2-DEHYDROPANTOATE2-REDUCTASE (Staphylococcusaureus) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | TYR A 40VAL A 126ILE A 117GLY A 11 | NoneNoneNoneNAP A 500 (-3.1A) | 0.80A | 2gssB-4s3mA:undetectable | 2gssB-4s3mA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr6 | DNA POLYMERASE IIISUBUNIT BETA (Bacillussubtilis) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | VAL A 23ILE A 31TYR A 125GLY A 48 | None | 0.92A | 2gssB-4tr6A:undetectable | 2gssB-4tr6A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqm | URACIL-DNAGLYCOSYLASE (Deinococcusradiodurans) |
PF03167(UDG) | 5 | TYR A 85VAL A 98ILE A 111TYR A 112GLY A 128 | CL A1245 (-4.3A)NoneNoneNoneNone | 1.10A | 2gssB-4uqmA:undetectable | 2gssB-4uqmA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w66 | GLUTATHIONES-TRANSFERASE DOMAINPROTEIN (Haliangiumochraceum) |
PF14497(GST_C_3) | 4 | TYR A 9PHE A 10VAL A 12TRP A 40 | None | 0.30A | 2gssB-4w66A:21.5 | 2gssB-4w66A:27.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w82 | FATTY ACID SYNTHASE (Homo sapiens) |
PF00107(ADH_zinc_N) | 4 | PHE A1831VAL A1854ILE A1544GLY A1833 | None | 0.93A | 2gssB-4w82A:undetectable | 2gssB-4w82A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c1e | PECTINESTERASE (Aspergillusniger) |
PF01095(Pectinesterase) | 4 | TYR A 73VAL A 102TYR A 67GLY A 89 | None | 0.91A | 2gssB-5c1eA:undetectable | 2gssB-5c1eA:20.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5d73 | GLUTATHIONES-TRANSFERASE (Wuchereriabancrofti) |
PF02798(GST_N)PF14497(GST_C_3) | 4 | TYR A 7PHE A 8TYR A 106GLY A 204 | NoneGSH A 301 (-4.9A)NoneNone | 0.48A | 2gssB-5d73A:31.0 | 2gssB-5d73A:42.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | GTP-BINDING NUCLEARPROTEIN RAN (Homo sapiens) |
PF00071(Ras) | 4 | TYR B 155VAL B 124TYR B 146GLY B 121 | None | 0.93A | 2gssB-5disB:undetectable | 2gssB-5disB:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewo | STRUCTURAL PROTEIN (Mamastrovirus 1) |
PF12226(Astro_capsid_p) | 4 | TYR A 588PHE A 582VAL A 543GLY A 546 | None | 0.90A | 2gssB-5ewoA:undetectable | 2gssB-5ewoA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5frs | SISTER CHROMATIDCOHESION PROTEINPDS5 (Saccharomycescerevisiae) |
PF12717(Cnd1) | 4 | TYR A 157VAL A 219ILE A 179GLY A 172 | None | 0.86A | 2gssB-5frsA:undetectable | 2gssB-5frsA:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Saccharomycescerevisiae) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | TYR B 859VAL B 968ARG B 942GLY B 947 | None | 0.85A | 2gssB-5ip9B:undetectable | 2gssB-5ip9B:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koh | NITROGENASE FEMOBETA SUBUNIT PROTEINNIFK (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 4 | TYR B 196PHE B 76ILE B 249GLY B 80 | None | 0.81A | 2gssB-5kohB:undetectable | 2gssB-5kohB:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x55 | PROBABLE URACIL-DNAGLYCOSYLASE (Acanthamoebapolyphagamimivirus) |
PF03167(UDG) | 4 | TYR A 193VAL A 211ILE A 224GLY A 241 | None | 0.81A | 2gssB-5x55A:undetectable | 2gssB-5x55A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 4 | PHE A 250VAL A 261ILE A 9GLY A 254 | None | 0.86A | 2gssB-5xwbA:undetectable | 2gssB-5xwbA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y0q | UPF0348 PROTEINB4417_3650 (Bacillussubtilis) |
no annotation | 4 | TYR A 72PHE A 41VAL A 76GLY A 45 | None | 0.85A | 2gssB-5y0qA:undetectable | 2gssB-5y0qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y37 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Streptococcusagalactiae) |
no annotation | 4 | VAL A 123ILE A 17TYR A 324GLY A 153 | NoneNAD A 401 (-4.3A)NAD A 401 (-3.6A)None | 0.94A | 2gssB-5y37A:undetectable | 2gssB-5y37A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z5k | DRAXINNETRIN RECEPTOR DCC (Rattusnorvegicus) |
no annotation | 4 | ARG B 282ILE A 387TYR A 398GLY A 396 | None | 0.94A | 2gssB-5z5kB:undetectable | 2gssB-5z5kB:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ap4 | DNA POLYMERASE IIISUBUNIT BETA (Acinetobacterbaumannii) |
no annotation | 4 | VAL A 21ILE A 29TYR A 119GLY A 46 | None | 0.93A | 2gssB-6ap4A:undetectable | 2gssB-6ap4A:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d79 | SULFATE TRANSPORTERCYSZ (Pseudomonasfragi) |
no annotation | 4 | VAL A 172TRP A 203ILE A 180GLY A 210 | None | 0.95A | 2gssB-6d79A:undetectable | 2gssB-6d79A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gsw | MU CLASS GLUTATHIONES-TRANSFERASE OFISOENZYME 3-3 (Rattus rattus) |
PF00043(GST_C)PF02798(GST_N) | 4 | TYR A 6VAL A 9ILE A 111TYR A 115 | NoneNoneGPS A 221 (-4.5A)None | 0.91A | 2gssB-6gswA:25.8 | 2gssB-6gswA:29.86 |