SIMILAR PATTERNS OF AMINO ACIDS FOR 2GQG_A_1N1A501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.74A 2gqgA-1k9aA:
33.6		 2gqgA-1k9aA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.82A 2gqgA-1opkA:
37.1		 2gqgA-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
ALA A 288
LYS A 290
MET A 309
VAL A 318
ILE A 332
THR A 334
PHE A 336
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.80A 2gqgA-1opkA:
37.1		 2gqgA-1opkA:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 389
LYS A 391
MET A 410
VAL A 419
PHE A 437
GLY A 441
LEU A 489
 None
 0.73A 2gqgA-1snxA:
31.3		 2gqgA-1snxA:
41.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.65A 2gqgA-2dq7X:
36.8		 2gqgA-2dq7X:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU X  17
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.76A 2gqgA-2dq7X:
36.8		 2gqgA-2dq7X:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.61A 2gqgA-2h8hA:
30.9		 2gqgA-2h8hA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.53A 2gqgA-2h8hA:
30.9		 2gqgA-2h8hA:
28.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 2gqgA-2hckA:
30.7		 2gqgA-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
PHE A 709
GLY A 713
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.66A 2gqgA-2henA:
32.6		 2gqgA-2henA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
PHE A 318
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.51A 2gqgA-2hk5A:
30.6		 2gqgA-2hk5A:
47.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
MET A 290
VAL A 299
ILE A 313
THR A 315
PHE A 317
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.80A 2gqgA-2hz0A:
35.5		 2gqgA-2hz0A:
97.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 269
LYS A 271
GLU A 286
ILE A 313
THR A 315
PHE A 317
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.91A 2gqgA-2hz0A:
35.5		 2gqgA-2hz0A:
97.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
ALA A 269
GLU A 286
MET A 290
VAL A 299
ILE A 313
THR A 315
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.90A 2gqgA-2hz0A:
35.5		 2gqgA-2hz0A:
97.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
ALA A 269
LYS A 271
GLU A 286
ILE A 313
THR A 315
PHE A 317
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-4.7A)
 0.97A 2gqgA-2hz0A:
35.5		 2gqgA-2hz0A:
97.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.64A 2gqgA-2j0jA:
33.1		 2gqgA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.70A 2gqgA-2j0jA:
33.1		 2gqgA-2j0jA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-3.5A)
None
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.65A 2gqgA-2jkmA:
33.0		 2gqgA-2jkmA:
40.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-2.9A)
None
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.64A 2gqgA-2jkmA:
33.0		 2gqgA-2jkmA:
40.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.88A 2gqgA-2og8A:
31.5		 2gqgA-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.97A 2gqgA-2og8A:
31.5		 2gqgA-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
LYS A 273
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.84A 2gqgA-2og8A:
31.5		 2gqgA-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
MET A 292
VAL A 301
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.74A 2gqgA-2og8A:
31.5		 2gqgA-2og8A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
GLY A 669
LEU A 785
 None
 0.84A 2gqgA-2ogvA:
22.7		 2gqgA-2ogvA:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 ALA A  34
LYS A  36
GLU A  53
MET A  57
VAL A  66
PHE A  84
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
AGS  A3001 ( 4.5A)
None
 0.81A 2gqgA-2pmiA:
23.3		 2gqgA-2pmiA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.75A 2gqgA-2psqA:
35.3		 2gqgA-2psqA:
35.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 215
LYS A 217
GLU A 230
THR A 265
PHE A 267
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.58A 2gqgA-2qluA:
26.9		 2gqgA-2qluA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 0.72A 2gqgA-2qobA:
27.4		 2gqgA-2qobA:
34.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.48A 2gqgA-2r2pA:
31.8		 2gqgA-2r2pA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
LYS A  49
GLU A  66
ILE A  93
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.63A 2gqgA-2xikA:
21.0		 2gqgA-2xikA:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
GLY A 705
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.59A 2gqgA-2xyuA:
29.3		 2gqgA-2xyuA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		11 LEU A 253
ALA A 273
GLU A 290
MET A 294
VAL A 303
ILE A 317
THR A 319
PHE A 321
GLY A 325
LEU A 374
ALA A 384
 None
 0.44A 2gqgA-2zv7A:
35.0		 2gqgA-2zv7A:
47.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 253
ALA A 273
LYS A 275
GLU A 290
MET A 294
VAL A 303
ILE A 317
PHE A 321
GLY A 325
ALA A 384
 None
 0.52A 2gqgA-2zv7A:
35.0		 2gqgA-2zv7A:
47.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.67A 2gqgA-3b2tA:
34.8		 2gqgA-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.64A 2gqgA-3b2tA:
34.8		 2gqgA-3b2tA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
GLY A 272
LEU A 321
 None
 0.74A 2gqgA-3d7uA:
28.1		 2gqgA-3d7uA:
43.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
PHE A 713
GLY A 717
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.56A 2gqgA-3dkoA:
31.3		 2gqgA-3dkoA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ALA A  80
LYS A  82
MET A 104
VAL A 113
GLY A 135
LEU A 182
ALA A 192
 None
 0.82A 2gqgA-3iecA:
25.4		 2gqgA-3iecA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.63A 2gqgA-3mdyA:
27.5		 2gqgA-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
LYS A 229
GLU A 242
THR A 277
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.66A 2gqgA-3my0A:
27.1		 2gqgA-3my0A:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.69A 2gqgA-3nyoA:
24.6		 2gqgA-3nyoA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.58A 2gqgA-3ppzA:
31.6		 2gqgA-3ppzA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.54A 2gqgA-3q4tA:
26.4		 2gqgA-3q4tA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 345
LYS A 368
GLU A 384
THR A 413
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-3.9A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.81A 2gqgA-3s95A:
20.2		 2gqgA-3s95A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
GLU A 384
MET A 388
THR A 413
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.70A 2gqgA-3s95A:
20.2		 2gqgA-3s95A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 423
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.48A 2gqgA-3sxsA:
35.0		 2gqgA-3sxsA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
PHE A 918
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
 0.85A 2gqgA-3vidA:
29.8		 2gqgA-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
LYS A 868
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.83A 2gqgA-3vidA:
29.8		 2gqgA-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.79A 2gqgA-3wzdA:
31.7		 2gqgA-3wzdA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
ALA A1978
LYS A1980
MET A2001
ILE A2024
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.63A 2gqgA-3zbfA:
28.9		 2gqgA-3zbfA:
39.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 649
GLU A 668
MET A 672
ILE A 695
THR A 697
PHE A 699
GLY A 703
LEU A 751
 None
 0.61A 2gqgA-3zfxA:
34.7		 2gqgA-3zfxA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
PHE A 699
GLY A 703
 None
 0.78A 2gqgA-3zfxA:
34.7		 2gqgA-3zfxA:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.69A 2gqgA-4agdA:
30.5		 2gqgA-4agdA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 121
GLU A 140
MET A 144
ILE A 167
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.52A 2gqgA-4aw5A:
29.4		 2gqgA-4aw5A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.56A 2gqgA-4aw5A:
29.4		 2gqgA-4aw5A:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
ALA A  63
GLU A  81
VAL A  94
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.85A 2gqgA-4bc6A:
23.0		 2gqgA-4bc6A:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  42
ALA A  63
LYS A  65
VAL A  94
ILE A 108
PHE A 112
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.89A 2gqgA-4bc6A:
23.0		 2gqgA-4bc6A:
29.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 2gqgA-4c02A:
27.2		 2gqgA-4c02A:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.60A 2gqgA-4f4pA:
34.9		 2gqgA-4f4pA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.72A 2gqgA-4fodA:
31.3		 2gqgA-4fodA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
GLY A 344
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.60A 2gqgA-4k11A:
30.7		 2gqgA-4k11A:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
ALA A 506
LYS A 508
GLU A 525
MET A 529
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.79A 2gqgA-4k33A:
31.6		 2gqgA-4k33A:
38.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 434
LYS A 436
MET A 456
VAL A 465
PHE A 483
GLY A 487
LEU A 533
 B49  A 701 (-3.2A)
None
None
None
B49  A 701 (-4.3A)
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.59A 2gqgA-4ks8A:
26.5		 2gqgA-4ks8A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.86A 2gqgA-4lg4A:
20.8		 2gqgA-4lg4A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  33
ALA A  54
LYS A  56
MET A  74
VAL A  83
ILE A  97
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.1A)
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.72A 2gqgA-4lg4A:
20.8		 2gqgA-4lg4A:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
GLU A 310
MET A 314
VAL A 323
ILE A 336
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.50A 2gqgA-4lggA:
30.8		 2gqgA-4lggA:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 273
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
ILE A 336
GLY A 344
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.62A 2gqgA-4lggA:
30.8		 2gqgA-4lggA:
46.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
ALA A  67
LYS A  69
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.66A 2gqgA-4o38A:
21.4		 2gqgA-4o38A:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		11 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
ILE A  79
THR A  81
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.49A 2gqgA-4ueuA:
35.8		 2gqgA-4ueuA:
65.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  40
ALA A  61
VAL A  92
ILE A 106
PHE A 110
GLY A 114
LEU A 162
ALA A 172
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
None
6UI  A 700 (-3.5A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
 0.68A 2gqgA-4usfA:
17.9		 2gqgA-4usfA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.83A 2gqgA-4wboA:
25.4		 2gqgA-4wboA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
ALA A  72
LYS A  74
MET A  94
VAL A 104
ILE A 124
PHE A 128
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-4.6A)
 0.89A 2gqgA-4wsqA:
25.0		 2gqgA-4wsqA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
ALA A  72
MET A  94
VAL A 104
ILE A 124
PHE A 128
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.80A 2gqgA-4wsqA:
25.0		 2gqgA-4wsqA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ALA A 348
LYS A 350
MET A 370
VAL A 379
PHE A 397
GLY A 401
LEU A 447
 ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
None
ATP  A 601 (-4.6A)
None
None
 0.76A 2gqgA-4xbrA:
21.2		 2gqgA-4xbrA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 10 ALA B 288
LYS B 290
MET B 309
VAL B 318
ILE B 332
THR B 334
PHE B 336
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.65A 2gqgA-4xeyB:
32.2		 2gqgA-4xeyB:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 10 LEU B 267
ALA B 288
MET B 309
VAL B 318
ILE B 332
THR B 334
PHE B 336
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.52A 2gqgA-4xeyB:
32.2		 2gqgA-4xeyB:
71.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 None
 0.72A 2gqgA-4xi2A:
27.4		 2gqgA-4xi2A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
GLU A 661
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.77A 2gqgA-4xufA:
30.5		 2gqgA-4xufA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
MET A 665
VAL A 675
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.77A 2gqgA-4xufA:
30.5		 2gqgA-4xufA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
LYS A 430
VAL A 458
ILE A 472
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.77A 2gqgA-4y93A:
31.6		 2gqgA-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
VAL A 458
ILE A 472
THR A 474
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.53A 2gqgA-4y93A:
31.6		 2gqgA-4y93A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 488
LYS A 490
ILE A 537
THR A 539
GLY A 545
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.82A 2gqgA-4yffA:
26.8		 2gqgA-4yffA:
29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.94A 2gqgA-5a46A:
30.8		 2gqgA-5a46A:
38.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
GLU A 290
THR A 325
PHE A 327
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.68A 2gqgA-5e8yA:
22.1		 2gqgA-5e8yA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.75A 2gqgA-5eykA:
21.2		 2gqgA-5eykA:
25.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.94A 2gqgA-5grnA:
25.8		 2gqgA-5grnA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.97A 2gqgA-5grnA:
25.8		 2gqgA-5grnA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
ALA A  77
LYS A  79
MET A  99
VAL A 109
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.77A 2gqgA-5i3oA:
24.8		 2gqgA-5i3oA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
PHE A  92
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 ( 4.2A)
 0.74A 2gqgA-5j5tA:
22.9		 2gqgA-5j5tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 ALA A  43
LYS A  45
MET A  65
VAL A  74
ILE A  88
PHE A  92
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.56A 2gqgA-5j5tA:
22.9		 2gqgA-5j5tA:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.62A 2gqgA-5j9zA:
32.4		 2gqgA-5j9zA:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 209
ALA A 228
LYS A 230
GLU A 250
GLY A 289
LEU A 338
ALA A 348
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
 0.76A 2gqgA-5ko1A:
26.8		 2gqgA-5ko1A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
ILE A 281
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.74A 2gqgA-5ko1A:
26.8		 2gqgA-5ko1A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 663
LYS A 665
MET A 686
ILE A 709
THR A 711
PHE A 713
LEU A 765
 6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-4.5A)
 0.67A 2gqgA-5l6oA:
31.8		 2gqgA-5l6oA:
38.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
ALA A  45
ILE A  93
THR A  95
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.83A 2gqgA-5w5jA:
19.1		 2gqgA-5w5jA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.74A 2gqgA-5wnoA:
28.2		 2gqgA-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 ALA A  54
LYS A  56
VAL A  83
ILE A  97
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.76A 2gqgA-6ao5A:
22.6		 2gqgA-6ao5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
ALA A  54
VAL A  83
ILE A  97
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.53A 2gqgA-6ao5A:
22.6		 2gqgA-6ao5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
ALA A 906
LYS A 908
GLU A 925
VAL A 938
PHE A 958
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.77A 2gqgA-6c7yA:
26.6		 2gqgA-6c7yA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 8 LEU U  20
ALA U  42
LYS U  44
VAL U  75
PHE U  93
GLY U  97
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.67A 2gqgA-6fdyU:
25.0		 2gqgA-6fdyU:
undetectable