SIMILAR PATTERNS OF AMINO ACIDS FOR 2GLU_B_SAMB302_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6d | THERMOSOME (BETASUBUNIT) (Thermoplasmaacidophilum) |
PF00118(Cpn60_TCP1) | 5 | GLY B 125HIS B 118ALA B 129ARG B 430ALA B 434 | None | 1.04A | 2gluB-1a6dB:undetectable | 2gluB-1a6dB:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ayy | GLYCOSYLASPARAGINASE (Elizabethkingiameningoseptica) |
PF01112(Asparaginase_2) | 5 | GLY B 214ALA B 202THR B 201ALA B 200ALA B 235 | None | 0.99A | 2gluB-1ayyB:undetectable | 2gluB-1ayyB:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanosarcinabarkeri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 6 | GLY A1322GLY A1506ALA A1347THR A1348ALA A1323PHE A1549 | None | 1.27A | 2gluB-1e6yA:undetectable | 2gluB-1e6yA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hkh | GAMMA LACTAMASE (Microbacterium) |
PF00561(Abhydrolase_1) | 6 | GLY A 62HIS A 37ALA A 193ALA A 197ALA A 189PHE A 159 | None | 1.48A | 2gluB-1hkhA:2.7 | 2gluB-1hkhA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kp2 | ARGININOSUCCINATESYNTHETASE (Escherichiacoli) |
PF00764(Arginosuc_synth) | 5 | GLY A 273GLY A 271HIS A 270ALA A 297PHE A 99 | None | 1.03A | 2gluB-1kp2A:2.1 | 2gluB-1kp2A:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74ALA A 138HIS A 141PHE A 142 | SAH A1900 (-3.1A)SAH A1900 (-3.2A)SAH A1900 (-3.2A)SAH A1900 (-4.4A)SAH A1900 ( 4.6A) | 0.75A | 2gluB-1kphA:18.0 | 2gluB-1kphA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpi | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 6 | GLY A 80GLY A 82THR A 86ALA A 146HIS A 149PHE A 150 | SAH A 900 (-3.3A)SAH A 900 (-3.1A)NoneSAH A 900 (-3.1A)SAH A 900 (-4.3A)None | 0.97A | 2gluB-1kpiA:17.2 | 2gluB-1kpiA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpl | PUTATIVE CLC FAMILY,CHLORINE TRANSPORTPROTEIN (Salmonellaenterica) |
PF00654(Voltage_CLC) | 5 | GLY A 303GLY A 306ALA A 141ALA A 87ALA A 82 | None | 0.96A | 2gluB-1kplA:undetectable | 2gluB-1kplA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74ALA A 138HIS A 141PHE A 142 | SAH A 900 (-3.1A)SAH A 900 (-3.4A)SAH A 900 (-3.4A)SAH A 900 ( 4.8A)SAH A 900 ( 4.7A) | 0.80A | 2gluB-1l1eA:18.1 | 2gluB-1l1eA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rw9 | CHONDROITIN AC LYASE (Paenarthrobacteraurescens) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 6 | HIS A 536ALA A 553THR A 552ALA A 550ARG A 533ALA A 609 | None | 1.46A | 2gluB-1rw9A:undetectable | 2gluB-1rw9A:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sq1 | CHORISMATE SYNTHASE (Campylobacterjejuni) |
PF01264(Chorismate_synt) | 5 | GLY A 14THR A 3ARG A 126ALA A 130PHE A 10 | None | 1.00A | 2gluB-1sq1A:undetectable | 2gluB-1sq1A:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8q | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE,PERIPLASMIC (Escherichiacoli) |
PF03009(GDPD) | 5 | GLY A 38HIS A 36THR A 345ALA A 52ALA A 59 | NoneGOL A1605 (-3.7A)NoneNoneNone | 0.99A | 2gluB-1t8qA:undetectable | 2gluB-1t8qA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ta9 | GLYCEROLDEHYDROGENASE (Schizosaccharomycespombe) |
PF00465(Fe-ADH) | 5 | GLY A 285THR A 288ALA A 221THR A 178ALA A 179 | None | 1.03A | 2gluB-1ta9A:undetectable | 2gluB-1ta9A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdj | BIOSYNTHETICTHREONINE DEAMINASE (Escherichiacoli) |
PF00291(PALP)PF00585(Thr_dehydrat_C) | 5 | GLY A 88HIS A 90ALA A 114THR A 113ALA A 120 | None | 1.01A | 2gluB-1tdjA:2.0 | 2gluB-1tdjA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tpy | METHOXY MYCOLIC ACIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74ALA A 138HIS A 141PHE A 142 | SAH A1900 (-3.2A)SAH A1900 (-3.3A)SAH A1900 (-3.1A)16A A1901 ( 4.2A)SAH A1900 (-4.6A) | 0.72A | 2gluB-1tpyA:18.2 | 2gluB-1tpyA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un9 | DIHYDROXYACETONEKINASE (Citrobacterfreundii) |
PF02733(Dak1)PF02734(Dak2) | 5 | GLY A 163GLY A 72THR A 75ALA A 179ALA A 166 | None | 1.02A | 2gluB-1un9A:undetectable | 2gluB-1un9A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un9 | DIHYDROXYACETONEKINASE (Citrobacterfreundii) |
PF02733(Dak1)PF02734(Dak2) | 6 | GLY A 163GLY A 72THR A 75ALA A 317THR A 320ALA A 166 | None | 1.02A | 2gluB-1un9A:undetectable | 2gluB-1un9A:19.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vl5 | UNKNOWN CONSERVEDPROTEIN BH2331 (Bacillushalodurans) |
PF08241(Methyltransf_11) | 7 | GLY A 52HIS A 55ALA A 99ARG A 115ALA A 117HIS A 120PHE A 121 | None | 0.40A | 2gluB-1vl5A:31.7 | 2gluB-1vl5A:34.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1vl5 | UNKNOWN CONSERVEDPROTEIN BH2331 (Bacillushalodurans) |
PF08241(Methyltransf_11) | 5 | GLY A 52THR A 73ALA A 99ALA A 117PHE A 121 | None | 0.87A | 2gluB-1vl5A:31.7 | 2gluB-1vl5A:34.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrq | SARCOSINE OXIDASEALPHA SUBUNIT (Corynebacteriumsp. U-96) |
PF01571(GCV_T)PF08669(GCV_T_C)PF12831(FAD_oxidored)PF13510(Fer2_4) | 5 | GLY A 431GLY A 435ALA A 247ALA A 427ALA A 141 | NoneNoneNoneNAD A1002 ( 4.0A)None | 0.97A | 2gluB-1vrqA:undetectable | 2gluB-1vrqA:12.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xxl | YCGJ PROTEIN (Bacillussubtilis) |
PF08241(Methyltransf_11) | 5 | ALA A 97ARG A 85ALA A 87HIS A 90PHE A 91 | NoneSO4 A 402 (-3.3A)NoneNoneNone | 0.97A | 2gluB-1xxlA:38.8 | 2gluB-1xxlA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xxl | YCGJ PROTEIN (Bacillussubtilis) |
PF08241(Methyltransf_11) | 11 | GLY A 20GLY A 22HIS A 25THR A 26ALA A 42THR A 43THR A 68ALA A 69ARG A 85ALA A 87HIS A 90 | NoneNoneSO4 A 402 (-4.2A)NoneNoneNoneNoneNoneSO4 A 402 (-3.3A)NoneNone | 0.52A | 2gluB-1xxlA:38.8 | 2gluB-1xxlA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xxl | YCGJ PROTEIN (Bacillussubtilis) |
PF08241(Methyltransf_11) | 11 | GLY A 20GLY A 22THR A 26ALA A 42THR A 43THR A 68ALA A 69ARG A 85ALA A 87HIS A 90PHE A 91 | NoneNoneNoneNoneNoneNoneNoneSO4 A 402 (-3.3A)NoneNoneNone | 0.61A | 2gluB-1xxlA:38.8 | 2gluB-1xxlA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1u | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION 5A (Mus musculus) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind) | 5 | ALA A 414THR A 351ALA A 350ALA A 371PHE A 444 | None | 1.02A | 2gluB-1y1uA:undetectable | 2gluB-1y1uA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 5 | GLY A 432GLY A 436ALA A 248ALA A 428ALA A 142 | NoneNoneNAD A 999 (-4.8A)NAD A 999 ( 4.1A)None | 0.98A | 2gluB-2gahA:undetectable | 2gluB-2gahA:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY A 212GLY A 388THR A 207ALA A 281ALA A 395ALA A 215 | None | 1.47A | 2gluB-2iwzA:undetectable | 2gluB-2iwzA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lak | AHSA1-LIKE PROTEINRHE_CH02687 (Rhizobium etli) |
PF08327(AHSA1) | 6 | GLY A 132HIS A 129ALA A 138ARG A 13ALA A 15HIS A 16 | None | 1.00A | 2gluB-2lakA:undetectable | 2gluB-2lakA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | GLY A 143GLY A 141HIS A 171ALA A 61THR A 27 | GLY A 143 ( 0.0A)GLY A 141 ( 0.0A)HIS A 171 ( 1.0A)ALA A 61 ( 0.0A)THR A 27 ( 0.8A) | 1.00A | 2gluB-2nvvA:undetectable | 2gluB-2nvvA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oaj | PROTEIN SNI1 (Saccharomycescerevisiae) |
PF08596(Lgl_C) | 5 | GLY A 507ALA A 470ALA A 873ALA A 524PHE A 510 | None | 1.03A | 2gluB-2oajA:undetectable | 2gluB-2oajA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vef | DIHYDROPTEROATESYNTHASE (Streptococcuspneumoniae) |
PF00809(Pterin_bind) | 5 | GLY A 192ALA A 188ARG A 129ALA A 126HIS A 123 | None | 0.94A | 2gluB-2vefA:undetectable | 2gluB-2vefA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vqa | SLL1358 PROTEIN (Synechocystissp. PCC 6803) |
PF00190(Cupin_1) | 5 | HIS A 235THR A 236THR A 228THR A 223ALA A 222 | None | 0.86A | 2gluB-2vqaA:undetectable | 2gluB-2vqaA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zc0 | ALANINE GLYOXYLATETRANSAMINASE (Thermococcuslitoralis) |
PF00155(Aminotran_1_2) | 5 | GLY A 107GLY A 109ALA A 242THR A 215ALA A 216 | PMP A 409 (-3.7A)NoneNoneNonePMP A 409 ( 3.7A) | 1.05A | 2gluB-2zc0A:undetectable | 2gluB-2zc0A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab7 | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA0350 (Thermusthermophilus) |
PF00582(Usp) | 5 | THR A 266ALA A 13THR A 7ALA A 6ALA A 133 | THR A 266 ( 0.8A)ALA A 13 ( 0.0A)THR A 7 ( 0.8A)ALA A 6 ( 0.0A)ALA A 133 ( 0.0A) | 1.02A | 2gluB-3ab7A:3.2 | 2gluB-3ab7A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cr8 | SULFATEADENYLYLTRANSFERASE,ADENYLYLSULFATEKINASE (Thiobacillusdenitrificans) |
PF01583(APS_kinase)PF01747(ATP-sulfurylase)PF14306(PUA_2) | 5 | GLY A 443GLY A 369ALA A 445THR A 371THR A 402 | None | 1.03A | 2gluB-3cr8A:undetectable | 2gluB-3cr8A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1c | FLAVIN-CONTAININGPUTATIVEMONOOXYGENASE (Staphylococcusaureus) |
PF13738(Pyr_redox_3) | 5 | GLY A 12GLY A 39THR A 138ALA A 137ALA A 13 | FAD A 500 (-3.5A)NoneFAD A 500 (-4.1A)NoneFAD A 500 (-3.5A) | 1.01A | 2gluB-3d1cA:undetectable | 2gluB-3d1cA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1t | HALOGENASE (Chondromycescrocatus) |
PF04820(Trp_halogenase) | 5 | GLY A 19GLY A 15THR A 320ALA A 323ALA A 23 | NoneFAD A 600 ( 4.9A)NoneNoneNone | 1.01A | 2gluB-3e1tA:undetectable | 2gluB-3e1tA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e49 | UNCHARACTERIZEDPROTEIN DUF849 WITHA TIM BARREL FOLD (Paraburkholderiaxenovorans) |
PF05853(BKACE) | 5 | GLY A 39THR A 78THR A 271ALA A 12ALA A 45 | None | 0.96A | 2gluB-3e49A:undetectable | 2gluB-3e49A:24.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e60 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN ]SYNTHASE II (Bartonellahenselae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 6 | GLY A 173GLY A 350THR A 168ALA A 244ALA A 357ALA A 176 | None | 1.46A | 2gluB-3e60A:undetectable | 2gluB-3e60A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ege | PUTATIVEMETHYLTRANSFERASEFROM ANTIBIOTICBIOSYNTHESIS PATHWAY (Trichormusvariabilis) |
PF08241(Methyltransf_11) | 5 | GLY A 41ALA A 84ALA A 102HIS A 104PHE A 106 | EDO A 261 (-3.2A)NoneEDO A 261 ( 3.8A)NoneNone | 0.97A | 2gluB-3egeA:16.7 | 2gluB-3egeA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ege | PUTATIVEMETHYLTRANSFERASEFROM ANTIBIOTICBIOSYNTHESIS PATHWAY (Trichormusvariabilis) |
PF08241(Methyltransf_11) | 6 | GLY A 41GLY A 43ALA A 84ALA A 102HIS A 105PHE A 106 | EDO A 261 (-3.2A)EDO A 261 ( 3.9A)NoneEDO A 261 ( 3.8A)EDO A 261 ( 4.6A)None | 0.47A | 2gluB-3egeA:16.7 | 2gluB-3egeA:25.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8a | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE G (Thermusthermophilus) |
PF02527(GidB) | 6 | GLY A 88GLY A 90ALA A 112THR A 113ALA A 139ARG A 158 | SAH A 303 (-3.0A)SAH A 303 (-3.5A)SAH A 303 (-3.6A)SAH A 303 (-4.2A)SAH A 303 (-3.8A)SAH A 303 (-3.9A) | 0.84A | 2gluB-3g8aA:14.2 | 2gluB-3g8aA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h77 | PQS BIOSYNTHETICENZYME (Pseudomonasaeruginosa) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | GLY A 164GLY A 139THR A 296ALA A 298ALA A 58 | None | 1.02A | 2gluB-3h77A:undetectable | 2gluB-3h77A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9m | P-AMINOBENZOATESYNTHETASE,COMPONENT I (Cytophagahutchinsonii) |
PF00425(Chorismate_bind) | 5 | GLY A 90HIS A 98THR A 99ALA A 86PHE A 334 | None | 0.98A | 2gluB-3h9mA:undetectable | 2gluB-3h9mA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hnr | PROBABLEMETHYLTRANSFERASEBT9727_4108 (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 5 | GLY A 53GLY A 55ALA A 115HIS A 118PHE A 98 | None | 0.69A | 2gluB-3hnrA:17.4 | 2gluB-3hnrA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kbh | SPIKE GLYCOPROTEIN (HumancoronavirusNL63) |
PF01600(Corona_S1) | 5 | GLY E 594ALA E 489THR E 490ALA E 491ALA E 583 | None | 0.95A | 2gluB-3kbhE:undetectable | 2gluB-3kbhE:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq2 | 16S RRNAMETHYLTRANSFERASE (Streptoalloteichustenebrarius) |
PF02390(Methyltransf_4) | 5 | GLY A 32GLY A 34ALA A 56THR A 86ALA A 87 | SAH A 216 (-3.5A)SAH A 216 (-3.4A)SAH A 216 (-3.8A)SAH A 216 (-4.4A)SAH A 216 (-3.5A) | 0.35A | 2gluB-3mq2A:12.2 | 2gluB-3mq2A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o04 | BETA-KETO-ACYLCARRIER PROTEINSYNTHASE II (Listeriamonocytogenes) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 347GLY A 236THR A 188THR A 15ALA A 350 | None | 0.99A | 2gluB-3o04A:undetectable | 2gluB-3o04A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8l | 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE (Oryctolaguscuniculus) |
PF00365(PFK) | 6 | GLY A 414THR A 544THR A 528ALA A 527ARG A 420ALA A 676 | NoneNonePO4 A 768 (-4.5A)NonePO4 A 767 (-4.4A)None | 1.31A | 2gluB-3o8lA:undetectable | 2gluB-3o8lA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3po0 | SMALL ARCHAEALMODIFIER PROTEIN 1 (Haloferaxvolcanii) |
PF02597(ThiS) | 5 | GLY A 69GLY A 29ALA A 71THR A 72ALA A 67 | None | 1.05A | 2gluB-3po0A:undetectable | 2gluB-3po0A:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3c | PROBABLE3-HYDROXYISOBUTYRATEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | GLY A 167GLY A 165ALA A 119ALA A 161HIS A 160 | None | 0.72A | 2gluB-3q3cA:4.8 | 2gluB-3q3cA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qha | PUTATIVEOXIDOREDUCTASE (Mycobacteriumavium) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | GLY A 173GLY A 171ALA A 125ALA A 167HIS A 166 | None | 0.81A | 2gluB-3qhaA:5.0 | 2gluB-3qhaA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qkg | PROTEIN AMBP (Homo sapiens) |
PF00061(Lipocalin) | 5 | GLY A 31THR A 162ALA A 29ALA A 150PHE A 146 | None | 0.96A | 2gluB-3qkgA:undetectable | 2gluB-3qkgA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qkg | PROTEIN AMBP (Homo sapiens) |
PF00061(Lipocalin) | 5 | THR A 33THR A 162ALA A 29ALA A 150PHE A 146 | None | 0.96A | 2gluB-3qkgA:undetectable | 2gluB-3qkgA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r7t | ADENYLOSUCCINATESYNTHETASE (Campylobacterjejuni) |
PF00709(Adenylsucc_synt) | 5 | GLY A 260GLY A 9ALA A 315THR A 314ALA A 322 | None | 1.02A | 2gluB-3r7tA:undetectable | 2gluB-3r7tA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slk | POLYKETIDE SYNTHASEEXTENDER MODULE 2 (Saccharopolysporaspinosa) |
PF08240(ADH_N)PF08659(KR)PF13602(ADH_zinc_N_2) | 5 | GLY A 519HIS A 688ALA A 597THR A 515ALA A 523 | NDP A 802 (-3.0A)NoneNoneNoneNone | 0.93A | 2gluB-3slkA:7.0 | 2gluB-3slkA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uel | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Rattusnorvegicus) |
PF05028(PARG_cat) | 5 | GLY A 720THR A 897THR A 863ALA A 862HIS A 715 | None | 1.03A | 2gluB-3uelA:undetectable | 2gluB-3uelA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrt | BETA-LACTAMASE (Chromohalobactersp. 560) |
PF00144(Beta-lactamase) | 5 | GLY A 107HIS A 113THR A 114THR A 163ALA A 88 | None | 0.92A | 2gluB-3wrtA:undetectable | 2gluB-3wrtA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b5q | GLYCOSIDE HYDROLASEFAMILY 61 PROTEIN D (Phanerochaetechrysosporium) |
PF03443(Glyco_hydro_61) | 5 | THR A 15ALA A 52THR A 51ALA A 91ALA A 164 | None | 0.94A | 2gluB-4b5qA:undetectable | 2gluB-4b5qA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bi9 | 3-KETOACYL-COATHIOLASE, PUTATIVE (Trypanosomabrucei) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLY A 58THR A 63ALA A 53ALA A 96ALA A 264 | None | 1.03A | 2gluB-4bi9A:undetectable | 2gluB-4bi9A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckb | MRNA-CAPPING ENZYMECATALYTIC SUBUNIT (Vaccinia virus) |
PF03291(Pox_MCEL)PF10640(Pox_ATPase-GT) | 5 | GLY A 600GLY A 602ALA A 618THR A 619ALA A 625 | SAH A1845 (-3.4A)NoneNoneNoneSAH A1845 ( 4.7A) | 1.03A | 2gluB-4ckbA:15.6 | 2gluB-4ckbA:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4es7 | PROTEIN AMBP (Homo sapiens) |
PF00061(Lipocalin) | 5 | GLY A 24THR A 155ALA A 22ALA A 143PHE A 139 | None | 0.99A | 2gluB-4es7A:undetectable | 2gluB-4es7A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4es7 | PROTEIN AMBP (Homo sapiens) |
PF00061(Lipocalin) | 5 | THR A 26THR A 155ALA A 22ALA A 143PHE A 139 | None | 0.87A | 2gluB-4es7A:undetectable | 2gluB-4es7A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewc | PUTATIVENUCLEOPROTEIN (Salmon isavirus) |
no annotation | 6 | GLY A 290GLY A 305THR A 379ALA A 446ALA A 288PHE A 447 | None | 1.44A | 2gluB-4ewcA:undetectable | 2gluB-4ewcA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hkj | CPXV203 PROTEIN (Cowpox virus) |
PF04490(Pox_T4_C)PF04491(Pox_T4_N) | 6 | GLY D 51GLY D 49THR D 79ALA D 24ARG D 53PHE D 27 | None | 1.35A | 2gluB-4hkjD:undetectable | 2gluB-4hkjD:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hv4 | UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE (Yersinia pestis) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | GLY A 33GLY A 28THR A 161ALA A 163ALA A 36 | None | 0.98A | 2gluB-4hv4A:4.3 | 2gluB-4hv4A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ict | CYTOCHROME P450 121 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | GLY A 358THR A 238ARG A 114ALA A 117PHE A 137 | NoneHEM A 405 ( 4.5A)NoneNoneNone | 0.89A | 2gluB-4ictA:undetectable | 2gluB-4ictA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ict | CYTOCHROME P450 121 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | GLY A 358THR A 238THR A 243ARG A 114PHE A 137 | NoneHEM A 405 ( 4.5A)NoneNoneNone | 1.02A | 2gluB-4ictA:undetectable | 2gluB-4ictA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 232GLY A 234ALA A 282ARG A 298HIS A 303 | SAH A 501 (-3.6A)SAH A 501 (-3.6A)SAH A 501 (-3.6A)NoneSAH A 501 (-4.0A) | 0.62A | 2gluB-4ineA:18.7 | 2gluB-4ineA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv8 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumknowlesi) |
PF08241(Methyltransf_11) | 5 | GLY A 61GLY A 63ARG A 125ALA A 127HIS A 130 | SAM A 301 (-3.5A)SAM A 301 ( 3.9A)NoneSAM A 301 (-3.4A)SAM A 301 (-3.9A) | 0.83A | 2gluB-4iv8A:18.2 | 2gluB-4iv8A:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iyo | CYSTATHIONINEGAMMA-LYASE-LIKEPROTEIN, LYS201AMODIFIED (Xanthomonasoryzae) |
PF01053(Cys_Met_Meta_PP) | 5 | GLY B 220ALA B 91THR B 92ALA B 84ALA B 208 | None | 1.02A | 2gluB-4iyoB:2.3 | 2gluB-4iyoB:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j05 | PHOSPHATETRANSPORTER (Serendipitaindica) |
PF00083(Sugar_tr) | 5 | GLY A 319GLY A 315THR A 433ALA A 430PHE A 393 | None | 0.99A | 2gluB-4j05A:undetectable | 2gluB-4j05A:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jga | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Rickettsiarickettsii) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 202GLY A 180HIS A 182ALA A 250ALA A 94 | None | 0.80A | 2gluB-4jgaA:undetectable | 2gluB-4jgaA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jy4 | PGT121 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY B 88THR B 105ALA B 85THR B 83ALA B 82 | None | 1.02A | 2gluB-4jy4B:undetectable | 2gluB-4jy4B:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 5 | GLY A 898GLY A 995ALA A 894ARG A 905PHE A 917 | None | 1.00A | 2gluB-4k0eA:undetectable | 2gluB-4k0eA:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | GLY A 228GLY A 230ALA A 278ARG A 294HIS A 299 | SAH A 701 (-3.5A)SAH A 701 (-3.5A)SAH A 701 (-3.7A)NoneSAH A 701 (-4.2A) | 0.62A | 2gluB-4kriA:19.2 | 2gluB-4kriA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6x | PHOSPHOLIPASE DSTSICTOX-BETAIC1 (Sicariusterrosus) |
no annotation | 5 | GLY A 106GLY A 144THR A 41ALA A 42ALA A 110 | None | 0.92A | 2gluB-4q6xA:undetectable | 2gluB-4q6xA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8f | RIBOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 5 | GLY A 39ALA A 249THR A 248THR A 253ALA A 47 | None | 1.03A | 2gluB-4x8fA:3.3 | 2gluB-4x8fA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynu | GLUCOSE OXIDASE,PUTATIVE (Aspergillusflavus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 12GLY A 14ALA A 37ALA A 235ALA A 275 | FAD A 601 (-3.3A)FAD A 601 (-3.4A)FAD A 601 (-3.6A)FAD A 601 (-3.5A)FAD A 601 (-3.8A) | 0.99A | 2gluB-4ynuA:3.3 | 2gluB-4ynuA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynu | GLUCOSE OXIDASE,PUTATIVE (Aspergillusflavus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 12GLY A 14ALA A 37THR A 234ALA A 235 | FAD A 601 (-3.3A)FAD A 601 (-3.4A)FAD A 601 (-3.6A)FAD A 601 (-4.3A)FAD A 601 (-3.5A) | 0.91A | 2gluB-4ynuA:3.3 | 2gluB-4ynuA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0k | LABDANE-RELATEDDITERPENE SYNTHASE (Streptomycessp.) |
no annotation | 5 | HIS A 133ALA A 143ALA A 195ALA A 152HIS A 149 | NoneNoneNoneGOL A1324 ( 4.1A)GOL A1324 ( 4.4A) | 1.01A | 2gluB-5a0kA:undetectable | 2gluB-5a0kA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3j | PUTATIVEQUINONE-OXIDOREDUCTASE HOMOLOG,CHLOROPLASTIC (Arabidopsisthaliana) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 6 | GLY A 169GLY A 167ALA A 163THR A 186ALA A 185ALA A 172 | None | 1.26A | 2gluB-5a3jA:7.8 | 2gluB-5a3jA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by2 | PHOSPHOHEPTOSEISOMERASE (Colwelliapsychrerythraea) |
PF13580(SIS_2) | 6 | GLY A 48GLY A 50THR A 118ALA A 115ALA A 56HIS A 55 | None | 1.25A | 2gluB-5by2A:undetectable | 2gluB-5by2A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doz | JAMJ (Lyngbyamajuscula) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 6 | GLY A 165GLY A 163ALA A 159THR A 182ALA A 181ALA A 168 | NoneNDP A 502 (-3.7A)NDP A 502 (-3.3A)NoneNoneNone | 1.36A | 2gluB-5dozA:8.6 | 2gluB-5dozA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dp1 | CURK (Mooreaproducens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | GLY A 165GLY A 163ALA A 159THR A 182ALA A 181ALA A 168 | NoneGOL A 403 ( 3.7A)NoneNoneNoneNone | 1.31A | 2gluB-5dp1A:8.8 | 2gluB-5dp1A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dp2 | CURF (Lyngbyamajuscula) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 6 | GLY A 167GLY A 165ALA A 161THR A 184ALA A 183ALA A 170 | NoneNAP A 401 (-3.5A)NAP A 401 ( 3.7A)NoneNoneNone | 1.33A | 2gluB-5dp2A:8.9 | 2gluB-5dp2A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gm2 | O-METHYLRANSFERASE (Streptomycesblastmyceticus) |
PF08241(Methyltransf_11) | 5 | GLY A 85GLY A 87THR A 91ALA A 136HIS A 157 | SAH A 301 (-3.2A)SAH A 301 (-3.1A)SAH A 301 (-4.2A)SAH A 301 (-3.4A)SAH A 301 ( 4.3A) | 1.00A | 2gluB-5gm2A:21.0 | 2gluB-5gm2A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmb | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Pseudomonasaeruginosa) |
PF00588(SpoU_methylase) | 6 | GLY A 19GLY A 16HIS A 14THR A 54ALA A 53ALA A 21 | None | 1.48A | 2gluB-5gmbA:undetectable | 2gluB-5gmbA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grh | ISOCITRATEDEHYDROGENASE [NAD]SUBUNIT GAMMA,MITOCHONDRIAL (Homo sapiens) |
PF00180(Iso_dh) | 5 | GLY B 253HIS B 323THR B 324ALA B 246ALA B 288 | None | 0.94A | 2gluB-5grhB:undetectable | 2gluB-5grhB:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h80 | CARBOXYLASE (Deinococcusradiodurans) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | GLY A 113THR A 108ALA A 122ALA A 287PHE A 284 | None | 0.98A | 2gluB-5h80A:2.7 | 2gluB-5h80A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdf | HYDROLASE (Streptomycesflocculus) |
no annotation | 6 | GLY B 305ALA B 303THR B 207ALA B 208ARG B 307ALA B 347 | None | 1.46A | 2gluB-5hdfB:2.5 | 2gluB-5hdfB:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mal | LIPASE (Streptomycesrimosus) |
PF13472(Lipase_GDSL_2) | 5 | GLY A 14ALA A 51THR A 50ALA A 36PHE A 47 | None | 1.02A | 2gluB-5malA:3.3 | 2gluB-5malA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nux | CHROMATE REDUCTASE (Thermusscotoductus) |
no annotation | 5 | THR A 110THR A 59ALA A 58ALA A 104HIS A 103 | NoneNoneFMN A1001 (-3.3A)NoneNone | 0.89A | 2gluB-5nuxA:undetectable | 2gluB-5nuxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5szs | SPIKE GLYCOPROTEIN (HumancoronavirusNL63) |
PF01600(Corona_S1)PF01601(Corona_S2) | 5 | GLY A 594ALA A 489THR A 490ALA A 491ALA A 583 | NoneNoneNAG A1437 ( 4.0A)NoneNone | 1.01A | 2gluB-5szsA:undetectable | 2gluB-5szsA:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2i | GLYCOSYLASPARAGINASE (Elizabethkingiameningoseptica) |
PF01112(Asparaginase_2) | 5 | GLY A 214ALA A 202THR A 201ALA A 200ALA A 235 | None | 1.01A | 2gluB-5v2iA:undetectable | 2gluB-5v2iA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yu1 | LYSINECYCLODEAMINASE (Streptomycespristinaespiralis) |
no annotation | 5 | GLY A 303HIS A 257THR A 118ALA A 208ALA A 235 | NAD A 402 ( 3.2A)NoneYCP A 403 (-4.0A)NAD A 402 (-4.4A) NA A 401 ( 4.1A) | 0.96A | 2gluB-5yu1A:6.4 | 2gluB-5yu1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zgb | PSAK (Cyanidioschyzonmerolae) |
no annotation | 5 | GLY K 24GLY K 20ALA K 38THR K 34ALA K 27 | NoneNoneBCR K 101 (-3.8A)NoneBCR K 101 ( 3.7A) | 1.00A | 2gluB-5zgbK:undetectable | 2gluB-5zgbK:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ar7 | UNCHARACTERIZEDPROTEIN (Burkholderiathailandensis) |
PF07007(LprI) | 5 | GLY A 152GLY A 150ALA A 147THR A 81ALA A 82 | None | 0.92A | 2gluB-6ar7A:undetectable | 2gluB-6ar7A:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6at7 | PHENYLALANINEAMMONIA-LYASE (Sorghum bicolor) |
no annotation | 5 | GLY A 393THR A 188ALA A 357THR A 358ALA A 485 | NoneMDO A 190 ( 4.4A)NoneNoneNone | 0.90A | 2gluB-6at7A:undetectable | 2gluB-6at7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6blg | DTDP-4-AMINO-4,6-DIDEOXYGALACTOSETRANSAMINASE (Klebsiellapneumoniae) |
no annotation | 5 | GLY A 173THR A 46ALA A 154ALA A 191PHE A 177 | NoneNoneLLP A 181 ( 3.3A)NoneNone | 0.80A | 2gluB-6blgA:2.5 | 2gluB-6blgA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evg | MULTI-COPPER OXIDASECUEO (Ochrobactrum) |
no annotation | 5 | GLY A 61GLY A 65ALA A 57THR A 43HIS A 46 | None | 1.03A | 2gluB-6evgA:undetectable | 2gluB-6evgA:undetectable |