SIMILAR PATTERNS OF AMINO ACIDS FOR 2GL0_F_ADNF906

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 ILE A 154
THR A 129
ALA A 146
VAL A 198
PHE A 150
 None
 1.43A 2gl0D-1fy2A:
0.0
2gl0F-1fy2A:
0.0		 2gl0D-1fy2A:
24.03
2gl0F-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASN A 246
ILE A 337
ALA A 385
ASN A 382
PHE A 244
 None
 1.43A 2gl0D-1h0hA:
undetectable
2gl0F-1h0hA:
undetectable		 2gl0D-1h0hA:
11.00
2gl0F-1h0hA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 337
ALA A 385
ASN A 382
VAL A 351
PHE A 244
 None
 1.09A 2gl0D-1h0hA:
undetectable
2gl0F-1h0hA:
undetectable		 2gl0D-1h0hA:
11.00
2gl0F-1h0hA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je5 HELIX-DESTABILIZING
PROTEIN

(Escherichia
virus T7) 		no annotation 5 ASN A  46
THR A 103
ASN A  99
VAL A  59
PHE A  96
 None
 1.46A 2gl0D-1je5A:
0.0
2gl0F-1je5A:
0.0		 2gl0D-1je5A:
20.57
2gl0F-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kru GALACTOSIDE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		5 ILE A  90
THR A  97
VAL A  64
PHE A  55
HIS A  77
 None
 1.45A 2gl0D-1kruA:
0.0
2gl0F-1kruA:
0.0		 2gl0D-1kruA:
23.01
2gl0F-1kruA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		5 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.41A 2gl0D-1nsvA:
0.0
2gl0F-1nsvA:
0.0		 2gl0D-1nsvA:
18.02
2gl0F-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		5 ILE A 273
THR A 317
ALA A 299
ASN A 300
HIS A 315
 None
 1.45A 2gl0D-1slqA:
0.0
2gl0F-1slqA:
undetectable		 2gl0D-1slqA:
18.35
2gl0F-1slqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		5 ILE A  87
ALA A 145
VAL A  31
PHE A  45
HIS A 120
 None
None
None
None
CU  A 155 (-3.0A)
 1.28A 2gl0D-1srdA:
0.3
2gl0F-1srdA:
0.3		 2gl0D-1srdA:
23.43
2gl0F-1srdA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vgg CONSERVED
HYPOTHETICAL PROTEIN
TT1634 (TTHA1091)

(Thermus
thermophilus) 		PF04008
(Adenosine_kin) 		6 ASN A  15
ILE A  93
THR A 112
ALA A 113
ASN A 114
TYR A 159
 None
 0.50A 2gl0D-1vggA:
26.1
2gl0F-1vggA:
26.2		 2gl0D-1vggA:
57.65
2gl0F-1vggA:
57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		6 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.35A 2gl0D-2ekmA:
27.7
2gl0F-2ekmA:
27.9		 2gl0D-2ekmA:
66.47
2gl0F-2ekmA:
66.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ILE A 133
ALA A 151
VAL A 195
PHE A 135
HIS A 140
 None
 1.04A 2gl0D-2eo5A:
undetectable
2gl0F-2eo5A:
undetectable		 2gl0D-2eo5A:
20.48
2gl0F-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 THR A 150
ALA A 151
VAL A 195
PHE A 135
HIS A 140
 None
 1.26A 2gl0D-2eo5A:
undetectable
2gl0F-2eo5A:
undetectable		 2gl0D-2eo5A:
20.48
2gl0F-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 ASN A 236
ALA A 237
VAL A 197
HIS A 253
PHE A 233
 None
 1.07A 2gl0D-2hxvA:
undetectable
2gl0F-2hxvA:
undetectable		 2gl0D-2hxvA:
20.88
2gl0F-2hxvA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jb7 HYPOTHETICAL PROTEIN
PAE2307

(Pyrobaculum
aerophilum) 		PF04008
(Adenosine_kin) 		8 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.22A 2gl0D-2jb7A:
29.8
2gl0F-2jb7A:
29.7		 2gl0D-2jb7A:
98.20
2gl0F-2jb7A:
98.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 ILE A  20
THR A  12
ALA A  11
VAL A  54
PHE A  19
 None
 1.48A 2gl0D-2vlcA:
undetectable
2gl0F-2vlcA:
undetectable		 2gl0D-2vlcA:
14.18
2gl0F-2vlcA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 ILE A 538
ALA A 476
VAL A 205
TYR A 199
PHE A 483
 None
 1.44A 2gl0D-2w5fA:
undetectable
2gl0F-2w5fA:
undetectable		 2gl0D-2w5fA:
14.88
2gl0F-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bby UNCHARACTERIZED
GST-LIKE PROTEIN
YFCF

(Escherichia
coli) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		5 ASN A 176
ILE A 206
THR A 194
ALA A 193
VAL A  24
 None
 1.22A 2gl0D-3bbyA:
undetectable
2gl0F-3bbyA:
undetectable		 2gl0D-3bbyA:
21.66
2gl0F-3bbyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  93
THR A  73
VAL A  22
TYR A 305
PHE A   7
 None
 1.43A 2gl0D-3i23A:
undetectable
2gl0F-3i23A:
undetectable		 2gl0D-3i23A:
21.49
2gl0F-3i23A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		no annotation 5 ILE A 220
THR A 360
VAL A 365
PHE A 334
HIS A 337
 None
 1.43A 2gl0D-3nv0A:
undetectable
2gl0F-3nv0A:
undetectable		 2gl0D-3nv0A:
22.27
2gl0F-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 AP-1 COMPLEX SUBUNIT
MU-1

(Mus musculus) 		no annotation 5 ILE M 277
THR M 306
VAL M 179
TYR M 418
PHE M 380
 None
 1.26A 2gl0D-4en2M:
undetectable
2gl0F-4en2M:
undetectable		 2gl0D-4en2M:
21.19
2gl0F-4en2M:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 5 ILE A 741
THR A 711
VAL A 147
PHE A 738
HIS A 707
 None
 1.37A 2gl0D-4fyeA:
undetectable
2gl0F-4fyeA:
undetectable		 2gl0D-4fyeA:
12.50
2gl0F-4fyeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ASN A   8
ILE A  35
THR A   9
ALA A   7
VAL A 293
 None
 1.42A 2gl0D-4ga7A:
undetectable
2gl0F-4ga7A:
undetectable		 2gl0D-4ga7A:
18.13
2gl0F-4ga7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 ILE A 138
ALA A  35
TYR A 182
PHE A 164
HIS A 132
 None
GOL  A 401 (-3.9A)
None
None
None
 1.42A 2gl0D-4gm6A:
undetectable
2gl0F-4gm6A:
undetectable		 2gl0D-4gm6A:
19.05
2gl0F-4gm6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 ILE A  25
THR A  17
ALA A  16
VAL A  60
PHE A  24
 None
 1.41A 2gl0D-4imvA:
undetectable
2gl0F-4imvA:
undetectable		 2gl0D-4imvA:
19.10
2gl0F-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 ILE B 329
THR B 278
ALA B 279
VAL B 338
HIS B 281
 None
 1.23A 2gl0D-4ol0B:
undetectable
2gl0F-4ol0B:
undetectable		 2gl0D-4ol0B:
12.43
2gl0F-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 ASN A 284
ILE A 278
THR A 237
ASN A 240
VAL A 320
 None
 1.45A 2gl0D-4z9nA:
undetectable
2gl0F-4z9nA:
undetectable		 2gl0D-4z9nA:
22.36
2gl0F-4z9nA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 ILE A  25
THR A  17
ALA A  16
VAL A  60
PHE A  24
 None
 1.44A 2gl0D-5ddzA:
undetectable
2gl0F-5ddzA:
undetectable		 2gl0D-5ddzA:
16.41
2gl0F-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		5 ASN A 439
ILE A 564
THR A 364
ALA A 363
PHE A 369
 None
 1.37A 2gl0D-5g56A:
undetectable
2gl0F-5g56A:
undetectable		 2gl0D-5g56A:
10.56
2gl0F-5g56A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		5 TRP A 367
ILE A 375
THR A 347
ALA A 348
PHE A 381
 None
 1.34A 2gl0D-5gzhA:
undetectable
2gl0F-5gzhA:
undetectable		 2gl0D-5gzhA:
18.55
2gl0F-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 TRP A 578
ILE A 635
THR A 572
TYR A 312
HIS A 477
 None
 1.40A 2gl0D-5jtaA:
undetectable
2gl0F-5jtaA:
undetectable		 2gl0D-5jtaA:
11.85
2gl0F-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltv CHEMOTACTIC
TRANSDUCER PCTC

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		5 THR A 218
ALA A 220
VAL A 264
TYR A 196
PHE A 198
 None
 1.36A 2gl0D-5ltvA:
undetectable
2gl0F-5ltvA:
undetectable		 2gl0D-5ltvA:
21.74
2gl0F-5ltvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 ILE A 227
THR A 231
ALA A 232
TYR A 216
PHE A 255
 None
 1.41A 2gl0D-5m86A:
2.3
2gl0F-5m86A:
2.2		 2gl0D-5m86A:
20.66
2gl0F-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ILE A 275
THR A 304
ALA A 305
VAL A 292
PHE A 271
 None
FAD  A 503 (-2.0A)
None
None
None
 1.33A 2gl0D-5vj7A:
undetectable
2gl0F-5vj7A:
undetectable		 2gl0D-5vj7A:
18.49
2gl0F-5vj7A:
18.49