SIMILAR PATTERNS OF AMINO ACIDS FOR 2GL0_E_ADNE905_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 PHE A 150
ILE A 154
THR A 129
ALA A 146
VAL A 198
 None
 1.47A 2gl0E-1fy2A:
0.0
2gl0F-1fy2A:
0.0		 2gl0E-1fy2A:
24.03
2gl0F-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 244
ILE A 337
ALA A 385
ASN A 382
VAL A 351
 None
 1.13A 2gl0E-1h0hA:
0.0
2gl0F-1h0hA:
undetectable		 2gl0E-1h0hA:
11.00
2gl0F-1h0hA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je5 HELIX-DESTABILIZING
PROTEIN

(Escherichia
virus T7) 		no annotation 5 PHE A  96
ASN A  46
THR A 103
ASN A  99
VAL A  59
 None
 1.45A 2gl0E-1je5A:
undetectable
2gl0F-1je5A:
0.0		 2gl0E-1je5A:
20.57
2gl0F-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		5 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.47A 2gl0E-1nsvA:
0.0
2gl0F-1nsvA:
0.0		 2gl0E-1nsvA:
18.02
2gl0F-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		5 HIS A 315
ILE A 273
THR A 317
ALA A 299
ASN A 300
 None
 1.42A 2gl0E-1slqA:
0.0
2gl0F-1slqA:
undetectable		 2gl0E-1slqA:
18.35
2gl0F-1slqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		5 PHE A  45
HIS A 120
ILE A  87
ALA A 145
VAL A  31
 None
CU  A 155 (-3.0A)
None
None
None
 1.30A 2gl0E-1srdA:
0.3
2gl0F-1srdA:
0.3		 2gl0E-1srdA:
23.43
2gl0F-1srdA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vgg CONSERVED
HYPOTHETICAL PROTEIN
TT1634 (TTHA1091)

(Thermus
thermophilus) 		PF04008
(Adenosine_kin) 		6 ASN A  15
ILE A  93
THR A 112
ALA A 113
ASN A 114
TYR A 159
 None
 0.43A 2gl0E-1vggA:
25.8
2gl0F-1vggA:
26.2		 2gl0E-1vggA:
57.65
2gl0F-1vggA:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		5 PHE A 183
ASN A 161
ILE A  85
THR A 157
VAL A 249
 None
 1.24A 2gl0E-2d0jA:
0.0
2gl0F-2d0jA:
0.3		 2gl0E-2d0jA:
22.57
2gl0F-2d0jA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		6 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.33A 2gl0E-2ekmA:
27.4
2gl0F-2ekmA:
27.9		 2gl0E-2ekmA:
66.47
2gl0F-2ekmA:
66.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PHE A 135
HIS A 140
ILE A 133
ALA A 151
VAL A 195
 None
 1.01A 2gl0E-2eo5A:
undetectable
2gl0F-2eo5A:
undetectable		 2gl0E-2eo5A:
20.48
2gl0F-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PHE A 135
HIS A 140
THR A 150
ALA A 151
VAL A 195
 None
 1.28A 2gl0E-2eo5A:
undetectable
2gl0F-2eo5A:
undetectable		 2gl0E-2eo5A:
20.48
2gl0F-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 HIS A 253
PHE A 233
ASN A 236
ALA A 237
VAL A 197
 None
 1.07A 2gl0E-2hxvA:
undetectable
2gl0F-2hxvA:
undetectable		 2gl0E-2hxvA:
20.88
2gl0F-2hxvA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jb7 HYPOTHETICAL PROTEIN
PAE2307

(Pyrobaculum
aerophilum) 		PF04008
(Adenosine_kin) 		8 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.17A 2gl0E-2jb7A:
29.5
2gl0F-2jb7A:
29.7		 2gl0E-2jb7A:
98.20
2gl0F-2jb7A:
98.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 PHE A 483
ILE A 538
ALA A 476
VAL A 205
TYR A 199
 None
 1.50A 2gl0E-2w5fA:
undetectable
2gl0F-2w5fA:
undetectable		 2gl0E-2w5fA:
14.88
2gl0F-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bby UNCHARACTERIZED
GST-LIKE PROTEIN
YFCF

(Escherichia
coli) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		5 ASN A 176
ILE A 206
THR A 194
ALA A 193
VAL A  24
 None
 1.24A 2gl0E-3bbyA:
undetectable
2gl0F-3bbyA:
undetectable		 2gl0E-3bbyA:
21.66
2gl0F-3bbyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 HIS A  79
PHE A  76
ALA A  31
VAL A 298
TYR A  61
 None
 1.25A 2gl0E-3f8rA:
undetectable
2gl0F-3f8rA:
undetectable		 2gl0E-3f8rA:
21.47
2gl0F-3f8rA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A   7
ILE A  93
THR A  73
VAL A  22
TYR A 305
 None
 1.45A 2gl0E-3i23A:
undetectable
2gl0F-3i23A:
undetectable		 2gl0E-3i23A:
21.49
2gl0F-3i23A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		no annotation 5 PHE A 334
HIS A 337
ILE A 220
THR A 360
VAL A 365
 None
 1.43A 2gl0E-3nv0A:
undetectable
2gl0F-3nv0A:
undetectable		 2gl0E-3nv0A:
22.27
2gl0F-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 HIS A 370
HIS A 327
ILE A  31
ALA A 354
TYR A  29
 None
 1.17A 2gl0E-3v4bA:
undetectable
2gl0F-3v4bA:
undetectable		 2gl0E-3v4bA:
16.67
2gl0F-3v4bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 HIS A 340
HIS A 271
ILE A 278
THR A 300
VAL A 323
 None
 1.46A 2gl0E-3zrpA:
undetectable
2gl0F-3zrpA:
1.1		 2gl0E-3zrpA:
19.33
2gl0F-3zrpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN

(Thermotoga
maritima) 		PF06964
(Alpha-L-AF_C) 		5 HIS A 469
PHE A 467
ILE A 479
THR A 470
VAL A 424
 None
 1.48A 2gl0E-4atwA:
undetectable
2gl0F-4atwA:
undetectable		 2gl0E-4atwA:
16.74
2gl0F-4atwA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 AP-1 COMPLEX SUBUNIT
MU-1

(Mus musculus) 		no annotation 5 PHE M 380
ILE M 277
THR M 306
VAL M 179
TYR M 418
 None
 1.27A 2gl0E-4en2M:
undetectable
2gl0F-4en2M:
undetectable		 2gl0E-4en2M:
21.19
2gl0F-4en2M:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 PHE A 164
HIS A 132
ILE A 138
ALA A  35
TYR A 182
 None
None
None
GOL  A 401 (-3.9A)
None
 1.40A 2gl0E-4gm6A:
undetectable
2gl0F-4gm6A:
undetectable		 2gl0E-4gm6A:
19.05
2gl0F-4gm6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 PHE A  60
HIS A  59
ILE A 133
THR A  84
ALA A 104
 None
 1.36A 2gl0E-4h27A:
undetectable
2gl0F-4h27A:
undetectable		 2gl0E-4h27A:
17.86
2gl0F-4h27A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.44A 2gl0E-4imvA:
undetectable
2gl0F-4imvA:
undetectable		 2gl0E-4imvA:
19.10
2gl0F-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 PHE A 179
HIS A 181
ILE A 201
THR A 204
ALA A 221
 None
 1.34A 2gl0E-4ntdA:
undetectable
2gl0F-4ntdA:
undetectable		 2gl0E-4ntdA:
18.37
2gl0F-4ntdA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 HIS B 281
ILE B 329
THR B 278
ALA B 279
VAL B 338
 None
 1.17A 2gl0E-4ol0B:
undetectable
2gl0F-4ol0B:
undetectable		 2gl0E-4ol0B:
12.43
2gl0F-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		5 ASN A  99
ILE A 228
THR A 224
ASN A  79
VAL A 206
 None
P33  A 501 ( 4.3A)
None
None
None
 1.26A 2gl0E-4w8oA:
undetectable
2gl0F-4w8oA:
undetectable		 2gl0E-4w8oA:
14.88
2gl0F-4w8oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 PHE B 116
HIS B 115
ASN B  45
ILE B  48
ALA B  44
 None
None
None
SO4  B1388 (-4.8A)
None
 1.31A 2gl0E-5a7vB:
undetectable
2gl0F-5a7vB:
undetectable		 2gl0E-5a7vB:
18.81
2gl0F-5a7vB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.47A 2gl0E-5ddzA:
undetectable
2gl0F-5ddzA:
undetectable		 2gl0E-5ddzA:
16.41
2gl0F-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 PHE C 861
ILE C 983
THR C1003
VAL C1029
TYR C1033
 None
 1.35A 2gl0E-5exrC:
undetectable
2gl0F-5exrC:
1.3		 2gl0E-5exrC:
10.41
2gl0F-5exrC:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		5 PHE A 381
TRP A 367
ILE A 375
THR A 347
ALA A 348
 None
 1.44A 2gl0E-5gzhA:
undetectable
2gl0F-5gzhA:
undetectable		 2gl0E-5gzhA:
18.55
2gl0F-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 HIS A 477
TRP A 578
ILE A 635
THR A 572
TYR A 312
 None
 1.35A 2gl0E-5jtaA:
undetectable
2gl0F-5jtaA:
undetectable		 2gl0E-5jtaA:
11.85
2gl0F-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 PHE A 255
ILE A 227
THR A 231
ALA A 232
TYR A 216
 None
 1.43A 2gl0E-5m86A:
undetectable
2gl0F-5m86A:
2.2		 2gl0E-5m86A:
20.66
2gl0F-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 PHE A 271
ILE A 275
THR A 304
ALA A 305
VAL A 292
 None
None
FAD  A 503 (-2.0A)
None
None
 1.35A 2gl0E-5vj7A:
undetectable
2gl0F-5vj7A:
undetectable		 2gl0E-5vj7A:
18.49
2gl0F-5vj7A:
18.49