SIMILAR PATTERNS OF AMINO ACIDS FOR 2GL0_D_ADND904

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 PHE C 491
SER C 509
ILE C 214
ALA C 184
VAL C 421
 None
 1.34A 2gl0D-1a5lC:
undetectable
2gl0E-1a5lC:
undetectable		 2gl0D-1a5lC:
15.58
2gl0E-1a5lC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1arl APO-CARBOXYPEPTIDASE
A=ALPHA= (COX)

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 SER A 254
HIS A 196
ALA A 143
ASN A 144
VAL A  49
 None
 1.01A 2gl0D-1arlA:
0.0
2gl0E-1arlA:
0.0		 2gl0D-1arlA:
16.39
2gl0E-1arlA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 PHE A 150
ILE A 154
THR A 129
ALA A 146
VAL A 198
 None
 1.44A 2gl0D-1fy2A:
0.0
2gl0E-1fy2A:
undetectable		 2gl0D-1fy2A:
24.03
2gl0E-1fy2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 244
ILE A 337
ALA A 385
ASN A 382
VAL A 351
 None
 1.13A 2gl0D-1h0hA:
undetectable
2gl0E-1h0hA:
0.0		 2gl0D-1h0hA:
11.00
2gl0E-1h0hA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je5 HELIX-DESTABILIZING
PROTEIN

(Escherichia
virus T7) 		no annotation 5 PHE A  96
ASN A  46
THR A 103
ASN A  99
VAL A  59
 None
 1.46A 2gl0D-1je5A:
0.0
2gl0E-1je5A:
undetectable		 2gl0D-1je5A:
20.57
2gl0E-1je5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kru GALACTOSIDE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		5 PHE A  55
HIS A  77
ILE A  90
THR A  97
VAL A  64
 None
 1.45A 2gl0D-1kruA:
undetectable
2gl0E-1kruA:
0.0		 2gl0D-1kruA:
23.01
2gl0E-1kruA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		5 ASN A 136
THR A 137
ALA A 175
ASN A 174
VAL A 210
 None
 1.30A 2gl0D-1m6sA:
0.0
2gl0E-1m6sA:
0.0		 2gl0D-1m6sA:
21.33
2gl0E-1m6sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		5 HIS E 210
PHE E 211
SER D 131
ALA E 240
VAL E 199
 None
 1.37A 2gl0D-1mi5E:
0.2
2gl0E-1mi5E:
0.3		 2gl0D-1mi5E:
23.39
2gl0E-1mi5E:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		5 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.45A 2gl0D-1nsvA:
undetectable
2gl0E-1nsvA:
undetectable		 2gl0D-1nsvA:
18.02
2gl0E-1nsvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		5 SER A  52
HIS A 135
ILE A 211
THR A 128
ASN A 130
 None
 1.20A 2gl0D-1s5pA:
undetectable
2gl0E-1s5pA:
undetectable		 2gl0D-1s5pA:
20.59
2gl0E-1s5pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 SER A 125
ILE A  11
ALA A 150
ASN A 123
VAL A 180
 None
 1.32A 2gl0D-1scjA:
undetectable
2gl0E-1scjA:
undetectable		 2gl0D-1scjA:
18.28
2gl0E-1scjA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		5 HIS A 315
ILE A 273
THR A 317
ALA A 299
ASN A 300
 None
 1.43A 2gl0D-1slqA:
undetectable
2gl0E-1slqA:
undetectable		 2gl0D-1slqA:
18.35
2gl0E-1slqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		5 PHE A  45
HIS A 120
ILE A  87
ALA A 145
VAL A  31
 None
CU  A 155 (-3.0A)
None
None
None
 1.17A 2gl0D-1srdA:
undetectable
2gl0E-1srdA:
undetectable		 2gl0D-1srdA:
23.43
2gl0E-1srdA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vgg CONSERVED
HYPOTHETICAL PROTEIN
TT1634 (TTHA1091)

(Thermus
thermophilus) 		PF04008
(Adenosine_kin) 		6 ASN A  15
ILE A  93
THR A 112
ALA A 113
ASN A 114
TYR A 159
 None
 0.45A 2gl0D-1vggA:
26.1
2gl0E-1vggA:
25.8		 2gl0D-1vggA:
57.65
2gl0E-1vggA:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 PHE A 234
HIS A 459
TRP A 406
ILE A 416
ASN A 699
 None
 1.41A 2gl0D-1x9sA:
3.7
2gl0E-1x9sA:
3.9		 2gl0D-1x9sA:
14.58
2gl0E-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3q THAUMATIN-LIKE
PROTEIN

(Musa acuminata) 		PF00314
(Thaumatin) 		5 SER A 113
ILE A  44
THR A   2
ALA A   1
ASN A 193
 None
 1.32A 2gl0D-1z3qA:
undetectable
2gl0E-1z3qA:
undetectable		 2gl0D-1z3qA:
20.00
2gl0E-1z3qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		5 PHE A 183
ASN A 161
ILE A  85
THR A 157
VAL A 249
 None
 1.24A 2gl0D-2d0jA:
undetectable
2gl0E-2d0jA:
undetectable		 2gl0D-2d0jA:
22.57
2gl0E-2d0jA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		6 ASN A  17
ILE A  94
THR A 113
ALA A 114
ASN A 115
TYR A 160
 None
 0.37A 2gl0D-2ekmA:
27.7
2gl0E-2ekmA:
27.4		 2gl0D-2ekmA:
66.47
2gl0E-2ekmA:
66.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PHE A 135
HIS A 140
ILE A 133
ALA A 151
VAL A 195
 None
 1.06A 2gl0D-2eo5A:
undetectable
2gl0E-2eo5A:
undetectable		 2gl0D-2eo5A:
20.48
2gl0E-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PHE A 135
HIS A 140
THR A 150
ALA A 151
VAL A 195
 None
 1.27A 2gl0D-2eo5A:
undetectable
2gl0E-2eo5A:
undetectable		 2gl0D-2eo5A:
20.48
2gl0E-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		5 HIS A 364
SER A  83
ILE A 391
THR A 115
ALA A 114
 None
 1.44A 2gl0D-2g28A:
undetectable
2gl0E-2g28A:
undetectable		 2gl0D-2g28A:
11.61
2gl0E-2g28A:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jb7 HYPOTHETICAL PROTEIN
PAE2307

(Pyrobaculum
aerophilum) 		PF04008
(Adenosine_kin) 		8 ASN A  20
TRP A  95
ILE A  97
THR A 116
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 ( 4.7A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.17A 2gl0D-2jb7A:
29.8
2gl0E-2jb7A:
29.5		 2gl0D-2jb7A:
98.20
2gl0E-2jb7A:
98.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 PHE A  19
ILE A  20
THR A  12
ALA A  11
VAL A  54
 None
 1.48A 2gl0D-2vlcA:
undetectable
2gl0E-2vlcA:
undetectable		 2gl0D-2vlcA:
14.18
2gl0E-2vlcA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bby UNCHARACTERIZED
GST-LIKE PROTEIN
YFCF

(Escherichia
coli) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		5 ASN A 176
ILE A 206
THR A 194
ALA A 193
VAL A  24
 None
 1.30A 2gl0D-3bbyA:
undetectable
2gl0E-3bbyA:
undetectable		 2gl0D-3bbyA:
21.66
2gl0E-3bbyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 HIS A  52
PHE A  60
SER A  39
ASN A  53
THR A  49
 None
 1.36A 2gl0D-3bitA:
0.7
2gl0E-3bitA:
undetectable		 2gl0D-3bitA:
18.26
2gl0E-3bitA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 ALPHA
CHAIN
TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		5 HIS B 203
PHE B 204
SER A 126
ALA B 233
VAL B 192
 None
 1.36A 2gl0D-3c60B:
undetectable
2gl0E-3c60B:
undetectable		 2gl0D-3c60B:
20.54
2gl0E-3c60B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 HIS A 426
PHE A 405
SER A 452
ALA A 464
VAL A 410
 None
 1.43A 2gl0D-3cdiA:
1.6
2gl0E-3cdiA:
undetectable		 2gl0D-3cdiA:
13.85
2gl0E-3cdiA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		5 PHE A 301
SER A  43
ILE A 241
ALA A  13
VAL A 254
 None
None
None
None
P6T  A 327 (-4.3A)
 1.28A 2gl0D-3gayA:
undetectable
2gl0E-3gayA:
undetectable		 2gl0D-3gayA:
18.90
2gl0E-3gayA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 PHE A  87
SER A  74
ILE A 285
THR A 308
VAL A 319
 None
 1.40A 2gl0D-3if2A:
undetectable
2gl0E-3if2A:
undetectable		 2gl0D-3if2A:
16.37
2gl0E-3if2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 SER A  25
HIS A 104
ILE A 185
THR A  97
ASN A  99
 None
 1.26A 2gl0D-3jr3A:
undetectable
2gl0E-3jr3A:
undetectable		 2gl0D-3jr3A:
24.08
2gl0E-3jr3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		5 PHE C 481
SER C 170
HIS C 512
ALA C 504
ASN C 503
 None
 1.44A 2gl0D-3mc6C:
undetectable
2gl0E-3mc6C:
undetectable		 2gl0D-3mc6C:
16.53
2gl0E-3mc6C:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		no annotation 5 PHE A 334
HIS A 337
ILE A 220
THR A 360
VAL A 365
 None
 1.44A 2gl0D-3nv0A:
undetectable
2gl0E-3nv0A:
undetectable		 2gl0D-3nv0A:
22.27
2gl0E-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		5 PHE A 279
SER A  43
ILE A 219
ALA A  13
VAL A 232
 None
None
None
None
13P  A 321 (-3.7A)
 1.19A 2gl0D-3q94A:
undetectable
2gl0E-3q94A:
undetectable		 2gl0D-3q94A:
22.22
2gl0E-3q94A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t38 ARSENATE REDUCTASE

(Corynebacterium
glutamicum) 		PF01451
(LMWPc) 		5 SER A 114
ILE A 194
ALA A  92
ASN A  91
VAL A 136
 None
 1.28A 2gl0D-3t38A:
undetectable
2gl0E-3t38A:
undetectable		 2gl0D-3t38A:
23.61
2gl0E-3t38A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		5 SER A 540
ASN A 556
ALA A 496
VAL A 128
TYR A 132
 None
EPE  A 805 (-3.4A)
EPE  A 805 ( 4.4A)
None
None
 1.42A 2gl0D-3w5fA:
undetectable
2gl0E-3w5fA:
undetectable		 2gl0D-3w5fA:
13.01
2gl0E-3w5fA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 HIS A 340
HIS A 271
ILE A 278
THR A 300
VAL A 323
 None
 1.47A 2gl0D-3zrpA:
undetectable
2gl0E-3zrpA:
undetectable		 2gl0D-3zrpA:
19.33
2gl0E-3zrpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 SER A 109
ILE A  57
THR A 154
ALA A 153
VAL A  91
 None
 1.48A 2gl0D-4a0hA:
undetectable
2gl0E-4a0hA:
undetectable		 2gl0D-4a0hA:
13.09
2gl0E-4a0hA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN

(Thermotoga
maritima) 		PF06964
(Alpha-L-AF_C) 		5 HIS A 469
PHE A 467
ILE A 479
THR A 470
VAL A 424
 None
 1.48A 2gl0D-4atwA:
undetectable
2gl0E-4atwA:
undetectable		 2gl0D-4atwA:
16.74
2gl0E-4atwA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 HIS A 419
HIS A 434
ILE A 382
ALA A 436
ASN A 435
 None
 1.42A 2gl0D-4b9yA:
undetectable
2gl0E-4b9yA:
undetectable		 2gl0D-4b9yA:
11.17
2gl0E-4b9yA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		5 HIS A 219
HIS A 233
ILE A 214
THR A 223
ASN A 228
 None
 1.39A 2gl0D-4e3eA:
undetectable
2gl0E-4e3eA:
undetectable		 2gl0D-4e3eA:
18.64
2gl0E-4e3eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		5 HIS A 219
ILE A 214
THR A 223
ASN A 228
VAL A 340
 None
 1.46A 2gl0D-4e3eA:
undetectable
2gl0E-4e3eA:
undetectable		 2gl0D-4e3eA:
18.64
2gl0E-4e3eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en2 AP-1 COMPLEX SUBUNIT
MU-1

(Mus musculus) 		no annotation 5 PHE M 380
ILE M 277
THR M 306
VAL M 179
TYR M 418
 None
 1.30A 2gl0D-4en2M:
undetectable
2gl0E-4en2M:
undetectable		 2gl0D-4en2M:
21.19
2gl0E-4en2M:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 SER A 363
ILE A 202
THR A 333
ALA A 334
TYR A 227
 None
 1.35A 2gl0D-4eziA:
undetectable
2gl0E-4eziA:
undetectable		 2gl0D-4eziA:
18.41
2gl0E-4eziA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ASN A   8
ILE A  35
THR A   9
ALA A   7
VAL A 293
 None
 1.48A 2gl0D-4ga7A:
undetectable
2gl0E-4ga7A:
undetectable		 2gl0D-4ga7A:
18.13
2gl0E-4ga7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 PHE A 164
HIS A 132
ILE A 138
ALA A  35
TYR A 182
 None
None
None
GOL  A 401 (-3.9A)
None
 1.38A 2gl0D-4gm6A:
undetectable
2gl0E-4gm6A:
undetectable		 2gl0D-4gm6A:
19.05
2gl0E-4gm6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 PHE A  60
HIS A  59
ILE A 133
THR A  84
ALA A 104
 None
 1.34A 2gl0D-4h27A:
undetectable
2gl0E-4h27A:
undetectable		 2gl0D-4h27A:
17.86
2gl0E-4h27A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.42A 2gl0D-4imvA:
undetectable
2gl0E-4imvA:
undetectable		 2gl0D-4imvA:
19.10
2gl0E-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Streptococcus
pneumoniae) 		PF01070
(FMN_dh) 		5 SER A 251
ASN A 117
ALA A  60
ASN A  59
VAL A 198
 FNR  A 404 ( 4.4A)
FNR  A 404 (-3.0A)
FNR  A 404 (-3.7A)
FNR  A 404 ( 4.0A)
None
 1.46A 2gl0D-4n02A:
undetectable
2gl0E-4n02A:
undetectable		 2gl0D-4n02A:
19.78
2gl0E-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 PHE A 179
HIS A 181
ILE A 201
THR A 204
ALA A 221
 None
 1.31A 2gl0D-4ntdA:
undetectable
2gl0E-4ntdA:
undetectable		 2gl0D-4ntdA:
18.37
2gl0E-4ntdA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 HIS B 281
ILE B 329
THR B 278
ALA B 279
VAL B 338
 None
 1.16A 2gl0D-4ol0B:
undetectable
2gl0E-4ol0B:
undetectable		 2gl0D-4ol0B:
12.43
2gl0E-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 SER A  24
HIS A 104
ILE A 182
THR A  97
ASN A  99
 None
 1.19A 2gl0D-4twiA:
undetectable
2gl0E-4twiA:
undetectable		 2gl0D-4twiA:
22.18
2gl0E-4twiA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		5 SER A 444
ILE A   9
THR A  35
ALA A  32
VAL A 210
 None
 1.47A 2gl0D-4whmA:
undetectable
2gl0E-4whmA:
undetectable		 2gl0D-4whmA:
16.19
2gl0E-4whmA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 PHE A 746
SER A 738
ILE A 747
THR A 742
VAL A 783
 None
None
ADP  A 903 (-3.6A)
None
None
 1.48A 2gl0D-4xhpA:
undetectable
2gl0E-4xhpA:
undetectable		 2gl0D-4xhpA:
12.82
2gl0E-4xhpA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 SER A 426
HIS A 423
ILE A 467
THR A 505
ALA A 459
 None
 1.39A 2gl0D-4xiiA:
undetectable
2gl0E-4xiiA:
undetectable		 2gl0D-4xiiA:
16.12
2gl0E-4xiiA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		5 HIS A 104
SER A 117
THR A 105
ASN A 257
TYR A 181
 FE  A 401 ( 3.2A)
None
None
None
None
 1.38A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		5 HIS A 104
SER A 117
THR A 105
ASN A 257
VAL A  86
 FE  A 401 ( 3.2A)
None
None
None
None
 1.42A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		5 SER A 117
HIS A 262
THR A 105
ASN A 257
TYR A 181
 None
FE  A 401 (-3.2A)
None
None
None
 1.20A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		5 SER A 117
HIS A 262
THR A 105
ASN A 257
VAL A  86
 None
FE  A 401 (-3.2A)
None
None
None
 1.10A 2gl0D-4y0eA:
undetectable
2gl0E-4y0eA:
undetectable		 2gl0D-4y0eA:
18.64
2gl0E-4y0eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 ASN A 284
ILE A 278
THR A 237
ASN A 240
VAL A 320
 None
 1.42A 2gl0D-4z9nA:
undetectable
2gl0E-4z9nA:
undetectable		 2gl0D-4z9nA:
22.36
2gl0E-4z9nA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 SER I 237
ILE I 196
ALA I 383
ASN I 235
VAL I 346
 None
 1.38A 2gl0D-4zoqI:
undetectable
2gl0E-4zoqI:
undetectable		 2gl0D-4zoqI:
18.70
2gl0E-4zoqI:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 PHE B 116
HIS B 115
ASN B  45
ILE B  48
ALA B  44
 None
None
None
SO4  B1388 (-4.8A)
None
 1.34A 2gl0D-5a7vB:
undetectable
2gl0E-5a7vB:
undetectable		 2gl0D-5a7vB:
18.81
2gl0E-5a7vB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.45A 2gl0D-5ddzA:
undetectable
2gl0E-5ddzA:
undetectable		 2gl0D-5ddzA:
16.41
2gl0E-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 PHE C 861
ILE C 983
THR C1003
VAL C1029
TYR C1033
 None
 1.41A 2gl0D-5exrC:
undetectable
2gl0E-5exrC:
undetectable		 2gl0D-5exrC:
10.41
2gl0E-5exrC:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		5 PHE A 381
TRP A 367
ILE A 375
THR A 347
ALA A 348
 None
 1.43A 2gl0D-5gzhA:
undetectable
2gl0E-5gzhA:
undetectable		 2gl0D-5gzhA:
18.55
2gl0E-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES1

(Chaetomium
thermophilum) 		no annotation 5 PHE o 103
SER o  70
ILE o 187
THR o 101
ALA o  36
 None
 1.39A 2gl0D-5jpqo:
undetectable
2gl0E-5jpqo:
undetectable		 2gl0D-5jpqo:
22.14
2gl0E-5jpqo:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 HIS A 477
TRP A 578
ILE A 635
THR A 572
TYR A 312
 None
 1.41A 2gl0D-5jtaA:
undetectable
2gl0E-5jtaA:
undetectable		 2gl0D-5jtaA:
11.85
2gl0E-5jtaA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltv CHEMOTACTIC
TRANSDUCER PCTC

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		5 PHE A 198
THR A 218
ALA A 220
VAL A 264
TYR A 196
 None
 1.37A 2gl0D-5ltvA:
undetectable
2gl0E-5ltvA:
undetectable		 2gl0D-5ltvA:
21.74
2gl0E-5ltvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 HIS A 189
SER A 226
ILE A 186
THR A 190
ASN A 220
 FE  A 401 (-3.3A)
None
ARG  A 403 (-4.7A)
None
None
 1.40A 2gl0D-5lunA:
undetectable
2gl0E-5lunA:
undetectable		 2gl0D-5lunA:
20.40
2gl0E-5lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 PHE A 255
ILE A 227
THR A 231
ALA A 232
TYR A 216
 None
 1.43A 2gl0D-5m86A:
2.3
2gl0E-5m86A:
undetectable		 2gl0D-5m86A:
20.66
2gl0E-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 PHE A  54
ALA A  73
ASN A  72
VAL A 142
TYR A 292
 None
 1.45A 2gl0D-5opqA:
undetectable
2gl0E-5opqA:
undetectable		 2gl0D-5opqA:
17.79
2gl0E-5opqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 PHE A 271
ILE A 275
THR A 304
ALA A 305
VAL A 292
 None
None
FAD  A 503 (-2.0A)
None
None
 1.34A 2gl0D-5vj7A:
undetectable
2gl0E-5vj7A:
undetectable		 2gl0D-5vj7A:
18.49
2gl0E-5vj7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 HIS A 405
PHE A 384
SER A 431
ALA A 443
VAL A 389
 None
 1.39A 2gl0D-6d6kA:
undetectable
2gl0E-6d6kA:
2.0		 2gl0D-6d6kA:
17.37
2gl0E-6d6kA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 5 HIS B 716
PHE B 713
ASN B 717
ILE B 982
VAL B 759
 None
 1.49A 2gl0D-6exvB:
undetectable
2gl0E-6exvB:
undetectable		 2gl0D-6exvB:
21.38
2gl0E-6exvB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa) 		no annotation 5 HIS C  60
PHE C  63
SER C  57
ASN C  55
TYR B 753
 None
 1.10A 2gl0D-6exvC:
undetectable
2gl0E-6exvC:
undetectable		 2gl0D-6exvC:
20.61
2gl0E-6exvC:
20.61