SIMILAR PATTERNS OF AMINO ACIDS FOR 2GL0_A_ADNA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 244
ASN A 246
ILE A 337
ALA A 385
ASN A 382
 None
 1.39A 2gl0A-1h0hA:
0.0
2gl0B-1h0hA:
0.0		 2gl0A-1h0hA:
11.00
2gl0B-1h0hA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 244
ILE A 337
ALA A 385
ASN A 382
VAL A 351
 None
 1.09A 2gl0A-1h0hA:
0.0
2gl0B-1h0hA:
0.0		 2gl0A-1h0hA:
11.00
2gl0B-1h0hA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		5 ILE A 153
ALA A  69
ASN A 166
VAL A 269
TYR A 334
 None
 1.42A 2gl0A-1nsvA:
0.0
2gl0B-1nsvA:
0.0		 2gl0A-1nsvA:
18.02
2gl0B-1nsvA:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vgg CONSERVED
HYPOTHETICAL PROTEIN
TT1634 (TTHA1091)

(Thermus
thermophilus) 		PF04008
(Adenosine_kin) 		5 ASN A  15
ILE A  93
ALA A 113
ASN A 114
TYR A 159
 None
 0.40A 2gl0A-1vggA:
25.8
2gl0B-1vggA:
26.1		 2gl0A-1vggA:
57.65
2gl0B-1vggA:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 PHE A 234
HIS A 459
TRP A 406
ILE A 416
ASN A 699
 None
 1.49A 2gl0A-1x9sA:
3.7
2gl0B-1x9sA:
3.6		 2gl0A-1x9sA:
14.58
2gl0B-1x9sA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 ILE A 518
ALA A 431
ASN A 533
VAL A 637
TYR A 696
 None
 1.48A 2gl0A-1z45A:
0.0
2gl0B-1z45A:
0.0		 2gl0A-1z45A:
16.70
2gl0B-1z45A:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		5 ASN A  17
ILE A  94
ALA A 114
ASN A 115
TYR A 160
 None
 0.29A 2gl0A-2ekmA:
27.6
2gl0B-2ekmA:
27.7		 2gl0A-2ekmA:
66.47
2gl0B-2ekmA:
66.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 PHE A 135
HIS A 140
ILE A 133
ALA A 151
VAL A 195
 None
 1.03A 2gl0A-2eo5A:
0.2
2gl0B-2eo5A:
0.0		 2gl0A-2eo5A:
20.48
2gl0B-2eo5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 HIS A 253
PHE A 233
ASN A 236
ALA A 237
VAL A 197
 None
 1.12A 2gl0A-2hxvA:
0.0
2gl0B-2hxvA:
0.0		 2gl0A-2hxvA:
20.88
2gl0B-2hxvA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jb7 HYPOTHETICAL PROTEIN
PAE2307

(Pyrobaculum
aerophilum) 		PF04008
(Adenosine_kin) 		7 ASN A  20
TRP A  95
ILE A  97
ALA A 117
ASN A 118
VAL A 163
TYR A 165
 AMP  A1168 (-3.4A)
AMP  A1168 ( 3.2A)
AMP  A1168 ( 4.5A)
AMP  A1168 (-3.2A)
AMP  A1168 (-3.5A)
AMP  A1168 (-4.7A)
AMP  A1168 (-4.5A)
 0.22A 2gl0A-2jb7A:
29.6
2gl0B-2jb7A:
29.8		 2gl0A-2jb7A:
98.20
2gl0B-2jb7A:
98.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		5 PHE A  44
HIS A 119
ILE A  86
ALA A 144
VAL A  30
 None
 1.20A 2gl0A-2q2lA:
undetectable
2gl0B-2q2lA:
undetectable		 2gl0A-2q2lA:
21.67
2gl0B-2q2lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 PHE A 483
ILE A 538
ALA A 476
VAL A 205
TYR A 199
 None
 1.44A 2gl0A-2w5fA:
undetectable
2gl0B-2w5fA:
undetectable		 2gl0A-2w5fA:
14.88
2gl0B-2w5fA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 HIS A 370
HIS A 327
ILE A  31
ALA A 354
TYR A  29
 None
 1.19A 2gl0A-3v4bA:
undetectable
2gl0B-3v4bA:
undetectable		 2gl0A-3v4bA:
16.67
2gl0B-3v4bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 HIS A 419
HIS A 434
ILE A 382
ALA A 436
ASN A 435
 None
 1.48A 2gl0A-4b9yA:
undetectable
2gl0B-4b9yA:
undetectable		 2gl0A-4b9yA:
11.17
2gl0B-4b9yA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE

(Listeria grayi) 		PF00294
(PfkB) 		5 PHE A 164
HIS A 132
ILE A 138
ALA A  35
TYR A 182
 None
None
None
GOL  A 401 (-3.9A)
None
 1.40A 2gl0A-4gm6A:
undetectable
2gl0B-4gm6A:
undetectable		 2gl0A-4gm6A:
19.05
2gl0B-4gm6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 PHE B 116
HIS B 115
ASN B  45
ILE B  48
ALA B  44
 None
None
None
SO4  B1388 (-4.8A)
None
 1.34A 2gl0A-5a7vB:
undetectable
2gl0B-5a7vB:
undetectable		 2gl0A-5a7vB:
18.81
2gl0B-5a7vB:
18.81