SIMILAR PATTERNS OF AMINO ACIDS FOR 2GJ5_A_VD3A163

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		5 VAL A 218
ILE A 249
ILE A 341
ILE A 319
ALA A 303
 None
 0.82A 2gj5A-1ad3A:
undetectable		 2gj5A-1ad3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by9 REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00511
(PPV_E2_C) 		5 LEU A 333
VAL A 331
LEU A 296
ILE A 354
ILE A 350
 None
 1.16A 2gj5A-1by9A:
0.0		 2gj5A-1by9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A 240
VAL A 242
ILE A 306
LEU A 308
ILE A 182
 None
 0.81A 2gj5A-1cliA:
0.0		 2gj5A-1cliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643

(Thermotoga
maritima) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 VAL A 180
VAL A 178
ILE A 169
ILE A 110
ALA A 109
 None
None
None
None
NAD  A1242 (-3.8A)
 1.23A 2gj5A-1h2hA:
0.0		 2gj5A-1h2hA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		5 VAL A 202
ILE A   9
ILE A  42
ILE A 218
ALA A  30
 None
 1.17A 2gj5A-1hg3A:
0.3		 2gj5A-1hg3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 126
VAL A 118
ILE A 304
LEU A 119
ILE A 303
 None
 0.94A 2gj5A-1i41A:
0.0		 2gj5A-1i41A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 VAL A 143
VAL A 145
GLU A 348
ILE A 132
ALA A 519
 None
 0.93A 2gj5A-1iq0A:
undetectable		 2gj5A-1iq0A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyo SICP

(Salmonella
enterica) 		PF05932
(CesT) 		5 LEU A  48
ILE A   7
LEU A 100
ILE A  11
PHE A  21
 None
 1.25A 2gj5A-1jyoA:
0.1		 2gj5A-1jyoA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		5 VAL A 348
ILE A 330
LEU A 328
ILE A 242
ALA A 314
 None
 1.13A 2gj5A-1kaeA:
0.0		 2gj5A-1kaeA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 VAL A  96
LEU A  99
GLU A 306
ALA A 191
PHE A 294
 None
 1.22A 2gj5A-1kwmA:
undetectable		 2gj5A-1kwmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 VAL A 258
ILE A 554
LYS A 166
ILE A 553
ALA A 312
 None
None
None
FAD  A3000 (-3.6A)
None
 1.14A 2gj5A-1m64A:
undetectable		 2gj5A-1m64A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		5 LEU A 409
VAL A 416
ILE A 344
ILE A 297
ALA A 299
 None
 1.14A 2gj5A-1morA:
undetectable		 2gj5A-1morA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxs KDPG ALDOLASE

(Pseudomonas
putida) 		PF01081
(Aldolase) 		5 LEU A  42
VAL A  81
LEU A  56
ILE A  33
ILE A  35
 None
 1.19A 2gj5A-1mxsA:
undetectable		 2gj5A-1mxsA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 107
VAL A  78
ILE A  51
ILE A  18
ALA A  43
 None
 1.09A 2gj5A-1poxA:
undetectable		 2gj5A-1poxA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 352
VAL A 199
LEU A 231
GLU A 357
ILE A  35
 LEU  A 352 ( 0.6A)
VAL  A 199 ( 0.6A)
LEU  A 231 ( 0.6A)
GLU  A 357 ( 0.6A)
ILE  A  35 ( 0.6A)
 1.14A 2gj5A-1tedA:
undetectable		 2gj5A-1tedA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 LEU A 136
VAL A 222
ILE A 205
LEU A 203
ILE A 193
 None
 0.85A 2gj5A-1txkA:
undetectable		 2gj5A-1txkA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbk HYPOTHETICAL PROTEIN
PH1313

(Pyrococcus
horikoshii) 		PF02568
(ThiI)
PF02926
(THUMP) 		5 VAL A 247
ILE A 183
ILE A 260
ALA A 194
PHE A 282
 None
 1.09A 2gj5A-1vbkA:
undetectable		 2gj5A-1vbkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 382
LEU A 384
ILE A 224
ALA A 178
PHE A 343
 None
 1.17A 2gj5A-1z1eA:
undetectable		 2gj5A-1z1eA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 863
VAL A 866
LEU A 790
ILE A 799
MET A 807
 None
 1.23A 2gj5A-2ax9A:
undetectable		 2gj5A-2ax9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 348
ILE A 387
ILE A 447
ALA A 451
MET A 415
 None
 1.12A 2gj5A-2bc0A:
undetectable		 2gj5A-2bc0A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg4 REGULATORY PROTEIN
ASNC

(Escherichia
coli) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		5 LEU A  92
VAL A  95
ILE A 107
ILE A  74
ILE A 133
 None
 1.06A 2gj5A-2cg4A:
undetectable		 2gj5A-2cg4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed6 25KDA STRUCTURAL
PROTEIN VP25

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		5 VAL A 196
VAL A 194
LEU A  52
ALA A  96
PHE A 122
 None
 0.99A 2gj5A-2ed6A:
undetectable		 2gj5A-2ed6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 LEU A 409
VAL A 416
ILE A 344
ILE A 297
ALA A 299
 None
 1.18A 2gj5A-2j6hA:
undetectable		 2gj5A-2j6hA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A  32
ILE A  34
ILE A 108
ALA A 122
PHE A  28
 None
 1.16A 2gj5A-2jkyA:
undetectable		 2gj5A-2jkyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 VAL A 629
ILE A 714
LEU A 627
ILE A 770
ALA A 766
 None
 1.07A 2gj5A-2np0A:
undetectable		 2gj5A-2np0A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 VAL A 125
ILE A 164
ILE A 196
ILE A 227
ALA A 244
 None
 0.97A 2gj5A-2o0rA:
undetectable		 2gj5A-2o0rA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 LEU A 132
VAL A 155
LEU A 157
ILE A 165
ALA A 145
 None
 1.18A 2gj5A-2o6wA:
undetectable		 2gj5A-2o6wA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A  59
LEU A  56
ILE A 254
ILE A 209
ALA A 208
 None
 1.09A 2gj5A-2pljA:
undetectable		 2gj5A-2pljA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q79 REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00511
(PPV_E2_C) 		5 LEU A 333
VAL A 331
LEU A 296
ILE A 354
ILE A 350
 None
 1.18A 2gj5A-2q79A:
undetectable		 2gj5A-2q79A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qco CMER

(Campylobacter
jejuni) 		PF00440
(TetR_N) 		5 ILE A  40
LEU A  36
GLU A  58
ILE A  39
ILE A  18
 None
 1.22A 2gj5A-2qcoA:
undetectable		 2gj5A-2qcoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 359
LEU A 355
ILE A 366
ILE A 383
ALA A 381
 None
 0.89A 2gj5A-2qkxA:
undetectable		 2gj5A-2qkxA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnu UNCHARACTERIZED
PROTEIN PA0076

(Pseudomonas
aeruginosa) 		PF09867
(DUF2094) 		5 LEU A  33
LEU A 201
ILE A  62
ALA A  92
PHE A 210
 None
 0.95A 2gj5A-2qnuA:
undetectable		 2gj5A-2qnuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		5 LEU A 278
ILE A 149
LEU A 285
ILE A 151
PHE A 414
 None
 1.09A 2gj5A-2qptA:
undetectable		 2gj5A-2qptA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 350
VAL A 121
LEU A 125
ILE A 266
ALA A 103
 None
 0.89A 2gj5A-2rdxA:
undetectable		 2gj5A-2rdxA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk5 PUTATIVE HEMOLYSIN

(Streptococcus
mutans) 		PF03471
(CorC_HlyC) 		5 VAL A  61
LEU A  68
LYS A  66
ILE A  85
PHE A  42
 None
 1.06A 2gj5A-2rk5A:
undetectable		 2gj5A-2rk5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 301
LEU A 298
ILE A 309
ILE A 326
ALA A 324
 None
 0.99A 2gj5A-2v0jA:
undetectable		 2gj5A-2v0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waw MOBA RELATE PROTEIN

(Mycobacterium
sp. DSM 3803) 		PF12804
(NTP_transf_3) 		5 LEU A 101
VAL A 114
ILE A 118
LEU A 117
PHE A  46
 None
 0.82A 2gj5A-2wawA:
undetectable		 2gj5A-2wawA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A 106
VAL A 109
VAL A 113
ILE A 171
ALA A 175
 None
 0.95A 2gj5A-2wpgA:
undetectable		 2gj5A-2wpgA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		5 LEU A 178
LEU A  15
ILE A  31
ILE A   4
ALA A  29
 None
 1.23A 2gj5A-2ywrA:
undetectable		 2gj5A-2ywrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8u TATA-BOX-BINDING
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00352
(TBP) 		5 LEU A 157
VAL A 142
LEU A 137
ILE A 170
ALA A 105
 None
 1.08A 2gj5A-2z8uA:
undetectable		 2gj5A-2z8uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq7 GROUP 1 TRUNCATED
HEMOGLOBIN

(Tetrahymena
pyriformis) 		PF01152
(Bac_globin) 		5 VAL A  28
ILE A  86
ILE A  87
ILE A 111
ALA A 107
 None
HEM  A 144 (-4.3A)
None
HEM  A 144 (-4.3A)
None
 1.16A 2gj5A-3aq7A:
undetectable		 2gj5A-3aq7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		5 LEU A 112
LYS A 115
ILE A  94
ILE A  67
ALA A  64
 None
 1.27A 2gj5A-3b1fA:
undetectable		 2gj5A-3b1fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		5 LEU A  22
VAL A 121
ILE A 123
LEU A 122
ALA A 160
 None
None
None
None
GNP  A   1 (-3.7A)
 1.21A 2gj5A-3bh6A:
undetectable		 2gj5A-3bh6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 ILE A  91
LEU A  86
GLU A  62
ILE A  94
ILE A 102
 None
 0.86A 2gj5A-3brqA:
undetectable		 2gj5A-3brqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 LEU A 105
VAL A 108
VAL A 112
ILE A 170
ALA A 174
 None
 0.94A 2gj5A-3czeA:
undetectable		 2gj5A-3czeA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A   4
VAL A   6
LEU A 113
ILE A  82
MET A 120
 None
 1.03A 2gj5A-3d1jA:
undetectable		 2gj5A-3d1jA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		5 VAL X  33
ILE X   9
LEU X   7
ILE X  58
ILE X 241
 None
 0.73A 2gj5A-3e13X:
undetectable		 2gj5A-3e13X:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 446
VAL A 433
VAL A 435
ILE A 269
MET A 212
 None
 1.19A 2gj5A-3fahA:
undetectable		 2gj5A-3fahA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A  24
LEU A  27
ILE A 109
ILE A  52
ALA A  88
 None
 1.04A 2gj5A-3h3zA:
undetectable		 2gj5A-3h3zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 VAL M 198
LEU M 200
ILE M 185
ILE M 159
ALA M 157
 None
 1.07A 2gj5A-3i04M:
undetectable		 2gj5A-3i04M:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ILE A  83
GLU A 121
ILE A  89
ILE A  93
ALA A  36
 None
GSH  A 234 (-4.4A)
None
None
None
 1.23A 2gj5A-3ibhA:
undetectable		 2gj5A-3ibhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 268
VAL P 264
ILE P 293
ILE P 294
PHE P 215
 None
 1.14A 2gj5A-3j9tP:
undetectable		 2gj5A-3j9tP:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1

(Homo sapiens) 		PF00013
(KH_1) 		5 VAL A 486
LEU A 488
ILE A 412
ILE A 420
ALA A 419
 GOL  A   4 ( 4.8A)
None
None
None
None
 0.97A 2gj5A-3krmA:
undetectable		 2gj5A-3krmA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 LEU A  39
VAL A  41
VAL A  43
ILE A  56
ILE A  84
PHE A 105
 None
 0.47A 2gj5A-3kzaA:
25.6		 2gj5A-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		7 LEU A  39
VAL A  41
VAL A  43
ILE A  56
LEU A  58
ILE A  71
ILE A  84
 None
 0.72A 2gj5A-3kzaA:
25.6		 2gj5A-3kzaA:
81.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 VAL A  92
ILE A 170
LEU A 168
ILE A 191
ALA A 236
 None
 0.83A 2gj5A-3n0vA:
undetectable		 2gj5A-3n0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  67
VAL A  85
ILE A  52
ILE A  43
MET A   2
 None
 1.14A 2gj5A-3nr3A:
5.9		 2gj5A-3nr3A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		5 ILE A  26
LEU A  28
ILE A 337
ILE A 380
ALA A 384
 None
 1.24A 2gj5A-3pgyA:
undetectable		 2gj5A-3pgyA:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		9 LEU A  55
VAL A  57
VAL A  59
ILE A  72
LEU A  74
LYS A  76
GLU A  78
ILE A  87
ILE A 100
 None
 0.65A 2gj5A-3ph5A:
29.2		 2gj5A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		9 LEU A  55
VAL A  57
VAL A  59
ILE A  72
LEU A  74
LYS A  76
GLU A  78
ILE A 100
PHE A 121
 None
 0.59A 2gj5A-3ph5A:
29.2		 2gj5A-3ph5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A 880
VAL A 615
VAL A 613
ILE A 607
ILE A 592
 None
 1.15A 2gj5A-3pihA:
undetectable		 2gj5A-3pihA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE

(Salmonella
enterica) 		PF01177
(Asp_Glu_race) 		5 VAL A 155
LEU A 174
ILE A 178
ILE A 189
ALA A 186
 None
 1.18A 2gj5A-3s7zA:
undetectable		 2gj5A-3s7zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 VAL A 218
ILE A 249
ILE A 341
ILE A 319
ALA A 303
 None
 0.88A 2gj5A-3szbA:
undetectable		 2gj5A-3szbA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 LEU A  89
LEU A 140
ILE A 154
ILE A 148
ALA A 121
 None
 1.24A 2gj5A-3t57A:
undetectable		 2gj5A-3t57A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		5 VAL A  72
LEU A  25
ILE A  85
ILE A 102
ALA A 101
 None
 0.96A 2gj5A-3tnyA:
undetectable		 2gj5A-3tnyA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 VAL A 147
LEU A   7
GLU A 143
ILE A   9
ILE A 169
 None
 1.01A 2gj5A-3uboA:
undetectable		 2gj5A-3uboA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 LEU A 232
VAL A 224
LEU A 225
ILE A 101
ALA A  56
 None
 0.99A 2gj5A-3vr0A:
undetectable		 2gj5A-3vr0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 VAL A 665
ILE A 750
LEU A 663
ILE A 806
ALA A 802
 None
 1.02A 2gj5A-3zuqA:
undetectable		 2gj5A-3zuqA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 LEU A 238
VAL A 240
LEU A 242
ILE A 250
ALA A 208
 None
 1.16A 2gj5A-4cp2A:
undetectable		 2gj5A-4cp2A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 309
VAL A 317
LEU A 322
ILE A 187
PHE A 110
 None
 0.74A 2gj5A-4dvjA:
undetectable		 2gj5A-4dvjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		5 LEU A  52
VAL A  48
GLU A  46
ILE A 231
ALA A  81
 None
 1.18A 2gj5A-4ef1A:
undetectable		 2gj5A-4ef1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A 178
LEU A  58
ILE A  56
ILE A  39
PHE A 166
 None
 1.20A 2gj5A-4hymA:
undetectable		 2gj5A-4hymA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ILE A 655
LEU A 657
ILE A 642
ILE A 624
ALA A 622
 None
 1.06A 2gj5A-4iglA:
undetectable		 2gj5A-4iglA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqn PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF16728
(DUF5066) 		5 VAL C  70
ILE C 125
ILE C 133
ILE C 148
ALA C 159
 None
 0.98A 2gj5A-4iqnC:
undetectable		 2gj5A-4iqnC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		5 ILE A  71
LEU A  22
GLU A  18
ILE A  72
ALA A  62
 FK5  A 201 ( 4.1A)
None
None
None
None
 1.23A 2gj5A-4odrA:
undetectable		 2gj5A-4odrA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 293
ILE A 370
LEU A 368
ILE A 406
PHE A 310
 None
 1.13A 2gj5A-4on9A:
undetectable		 2gj5A-4on9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7a DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 GLU A 172
ILE A  25
ILE A 107
ALA A 111
MET A  35
 None
 1.15A 2gj5A-4p7aA:
undetectable		 2gj5A-4p7aA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM

(Vespa basalis) 		PF00151
(Lipase) 		5 VAL A  46
ILE A  78
LEU A  76
ILE A  31
MET A 119
 None
 1.04A 2gj5A-4qnnA:
undetectable		 2gj5A-4qnnA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 LEU A 108
VAL A  99
VAL A 101
ILE A 209
ALA A 130
 None
 1.16A 2gj5A-4uovA:
undetectable		 2gj5A-4uovA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 LEU A 634
ILE A 604
LEU A 605
ILE A 601
ALA A 583
 None
None
None
CL  A 905 (-4.6A)
CL  A 905 ( 4.1A)
 0.70A 2gj5A-5c1bA:
undetectable		 2gj5A-5c1bA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 VAL A 343
ILE A 303
GLU A 292
ILE A 269
ILE A 274
 None
 1.16A 2gj5A-5c1bA:
undetectable		 2gj5A-5c1bA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca) 		PF01497
(Peripla_BP_2) 		5 LEU A 358
VAL A 350
ILE A 262
LEU A 351
GLU A 226
 None
 1.25A 2gj5A-5dh2A:
undetectable		 2gj5A-5dh2A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezo C12 FAB

(Plasmodium
falciparum) 		no annotation 5 VAL A 333
ILE A 343
LEU A 341
GLU A  38
ILE A  42
 None
 1.26A 2gj5A-5ezoA:
undetectable		 2gj5A-5ezoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 VAL B 565
LEU B 567
ILE B 528
ILE B 532
PHE B 580
 None
 1.24A 2gj5A-5gqrB:
undetectable		 2gj5A-5gqrB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 VAL A 126
ILE A 137
LEU A 135
GLU A  77
ILE A  86
 None
 1.20A 2gj5A-5iw7A:
undetectable		 2gj5A-5iw7A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 LEU A 292
VAL A  74
ILE A  81
ALA A 307
PHE A  89
 None
None
NAD  A 901 (-3.8A)
None
None
 1.18A 2gj5A-5jydA:
undetectable		 2gj5A-5jydA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 LEU A 101
GLU A  94
ILE A 297
ILE A 244
PHE A 305
 None
 1.13A 2gj5A-5l2pA:
undetectable		 2gj5A-5l2pA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU A2038
VAL A2041
VAL A2045
ILE A2019
ILE A2030
 None
 1.10A 2gj5A-5m5pA:
undetectable		 2gj5A-5m5pA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		5 LEU A 270
VAL A 433
ILE A 403
ILE A 137
ALA A 196
 None
 1.13A 2gj5A-5mwlA:
undetectable		 2gj5A-5mwlA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 VAL A  93
VAL A  89
LEU A  90
ILE A 233
ILE A 234
 None
 0.89A 2gj5A-5odoA:
undetectable		 2gj5A-5odoA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 5 VAL A 358
ILE A 332
LEU A 330
GLU A 304
ILE A 311
 None
 1.17A 2gj5A-5u8qA:
undetectable		 2gj5A-5u8qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC

(Medicago
truncatula) 		PF00815
(Histidinol_dh) 		5 VAL A 389
ILE A 371
LEU A 369
ILE A 282
ALA A 351
 None
 1.06A 2gj5A-5vldA:
undetectable		 2gj5A-5vldA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		5 ILE A  75
GLU A  68
ILE A   8
ILE A  58
ALA A  57
 None
 1.19A 2gj5A-5x47A:
undetectable		 2gj5A-5x47A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00276
(Ribosomal_L23) 		5 VAL U 157
VAL U 159
ILE U 176
LEU U 178
GLU U 186
 None
 1.24A 2gj5A-5x8tU:
undetectable		 2gj5A-5x8tU:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyk PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		no annotation 5 VAL E 132
ILE E  78
LEU E 120
ILE E  80
ALA E 240
 None
None
None
None
UDP  E 403 (-3.5A)
 1.15A 2gj5A-5xykE:
undetectable		 2gj5A-5xykE:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		no annotation 5 VAL A  49
LEU A  13
ILE A  17
ILE A  68
ALA A  26
 None
 1.22A 2gj5A-6az6A:
undetectable		 2gj5A-6az6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6baq BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Mus musculus) 		no annotation 5 LEU A 181
VAL A 179
LEU A 164
ILE A 135
ILE A  96
 None
 1.21A 2gj5A-6baqA:
undetectable		 2gj5A-6baqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 VAL X  99
ILE X 233
LEU X 229
ILE X 232
ILE X 115
 None
 1.23A 2gj5A-6elqX:
undetectable		 2gj5A-6elqX:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 VAL A 577
ILE A 384
LEU A 625
ILE A 642
ILE A 645
 None
 0.88A 2gj5A-6fikA:
undetectable		 2gj5A-6fikA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g74 QUINOLINATE SYNTHASE
A

(Thermotoga
maritima) 		no annotation 5 VAL A 276
ILE A 283
LEU A 278
ILE A  65
ALA A  43
 None
 1.24A 2gj5A-6g74A:
undetectable		 2gj5A-6g74A:
18.75