SIMILAR PATTERNS OF AMINO ACIDS FOR 2G78_A_REAA200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		5 PHE A  99
ILE A 116
ALA A 115
THR A  91
VAL A 119
 None
 1.16A 2g78A-1bhwA:
undetectable		 2g78A-1bhwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		5 PHE A 428
LEU A  23
ILE A 125
ALA A  87
THR A 130
 None
 1.17A 2g78A-1gnxA:
0.0		 2g78A-1gnxA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 PHE A 304
ILE A 477
ALA A 478
THR A 512
VAL A 506
 None
 1.14A 2g78A-1i1qA:
0.0		 2g78A-1i1qA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		5 ILE A 262
ALA A 259
THR A  96
VAL A 230
LEU A  80
 None
 1.07A 2g78A-1j32A:
undetectable		 2g78A-1j32A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		5 LEU A 255
ILE A 262
ALA A 259
THR A  96
VAL A 230
 None
 1.10A 2g78A-1j32A:
undetectable		 2g78A-1j32A:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 PHE A  16
ILE A  32
ALA A  33
THR A  53
LEU A 117
 None
 0.58A 2g78A-1kqxA:
20.9		 2g78A-1kqxA:
40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
ILE A  32
ALA A  33
THR A  53
LEU A 117
MET A 119
 None
 0.67A 2g78A-1lpjA:
20.3		 2g78A-1lpjA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		5 LEU A1025
ILE A1008
ALA A1016
VAL A1138
LEU A1168
 None
 1.04A 2g78A-1lurA:
0.0		 2g78A-1lurA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 227
ALA A 218
THR A 241
VAL A 248
ARG A 352
 None
None
None
PGE  A1403 ( 4.1A)
PO4  A1404 (-2.9A)
 1.12A 2g78A-1ozhA:
undetectable		 2g78A-1ozhA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr7 FIMH PROTEIN

(Escherichia
coli) 		no annotation 5 LEU B 129
ILE B 126
ALA B 127
VAL B  67
VAL B  75
 None
 1.11A 2g78A-1tr7B:
undetectable		 2g78A-1tr7B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		6 LEU A 345
ILE A 404
ALA A 403
VAL A 341
LEU A 204
MET A 200
 None
 1.38A 2g78A-1v9lA:
undetectable		 2g78A-1v9lA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		5 PHE B 235
LEU B 239
ILE B 325
ALA B 324
THR B 319
 None
 1.11A 2g78A-1xdkB:
undetectable		 2g78A-1xdkB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 PHE A 144
LEU A 121
ILE A 104
ALA A 132
VAL A 141
 None
 0.87A 2g78A-1xtpA:
undetectable		 2g78A-1xtpA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 LEU A1272
ALA A1280
THR A1319
VAL A1315
LEU A1187
 None
 1.14A 2g78A-1yxoA:
undetectable		 2g78A-1yxoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 LEU A1272
ALA A1280
THR A1319
VAL A1315
LEU A1191
 None
 1.16A 2g78A-1yxoA:
undetectable		 2g78A-1yxoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 ALA A 433
THR A  95
VAL A  89
VAL A 437
LEU A  40
 None
SEP  A  92 ( 4.1A)
None
None
None
 1.12A 2g78A-1zefA:
undetectable		 2g78A-1zefA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 LEU A 194
ILE A  87
THR A  16
VAL A 116
LEU A 103
 None
 1.11A 2g78A-2aaaA:
undetectable		 2g78A-2aaaA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2

(Carnivore
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 LEU A 482
ILE A 357
ALA A 358
THR A 278
THR A 406
 None
 1.05A 2g78A-2casA:
undetectable		 2g78A-2casA:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		9 PHE A  15
LEU A  19
ALA A  32
THR A  54
THR A  56
VAL A  58
VAL A  76
ARG A 111
LEU A 120
 None
None
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
None
None
None
 0.54A 2g78A-2cbrA:
26.9		 2g78A-2cbrA:
75.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		6 PHE A  15
LEU A  19
ALA A  32
THR A  61
VAL A  58
VAL A  76
 None
None
A80  A 201 ( 4.1A)
None
None
None
 1.37A 2g78A-2cbrA:
26.9		 2g78A-2cbrA:
75.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfe RIBONUCLEASE HII

(Thermococcus
kodakarensis) 		PF01351
(RNase_HII) 		5 PHE A 114
LEU A 118
ALA A 104
VAL A 141
LEU A  80
 None
 0.98A 2g78A-2dfeA:
undetectable		 2g78A-2dfeA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		5 LEU A 197
ILE A 204
ALA A 200
VAL A 160
LEU A 187
 None
 0.93A 2g78A-2ehjA:
undetectable		 2g78A-2ehjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		5 PHE A 175
THR A   9
VAL A 246
VAL A 214
LEU A 122
 None
 1.09A 2g78A-2f1nA:
undetectable		 2g78A-2f1nA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 ALA A 437
THR A  61
VAL A 411
VAL A 429
LEU A 279
 None
 1.11A 2g78A-2jjfA:
undetectable		 2g78A-2jjfA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 PHE A 328
LEU A 355
ILE A 394
ALA A 393
THR A 418
 None
 1.16A 2g78A-2o1xA:
undetectable		 2g78A-2o1xA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 LEU A 141
ILE A 183
VAL A 170
LEU A 195
MET A  68
 None
 1.02A 2g78A-2o3iA:
undetectable		 2g78A-2o3iA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 LEU A 137
ALA A 179
VAL A 196
VAL A 131
LEU A 265
 None
 1.10A 2g78A-2pfyA:
undetectable		 2g78A-2pfyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 5 PHE A 168
LEU A 172
ALA A  28
VAL A  76
LEU A 101
 None
 0.85A 2g78A-2qjwA:
undetectable		 2g78A-2qjwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		5 PHE A 161
LEU A 211
THR A  23
VAL A  22
LEU A  87
 None
None
SO4  A 216 ( 3.2A)
None
None
 1.03A 2g78A-2qsxA:
undetectable		 2g78A-2qsxA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ILE A  32
ALA A  33
THR A  53
LEU A 117
 None
 0.55A 2g78A-2rcqA:
19.3		 2g78A-2rcqA:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		5 LEU A 522
ILE A 525
ALA A 515
THR A 375
VAL A 562
 None
 1.14A 2g78A-2vpjA:
undetectable		 2g78A-2vpjA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 LEU A 752
ILE A 755
ALA A 669
THR A 742
VAL A 690
 None
 1.07A 2g78A-2wl1A:
undetectable		 2g78A-2wl1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 170
LEU A 179
ILE A 216
VAL A 156
LEU A 144
 None
 1.12A 2g78A-2z80A:
undetectable		 2g78A-2z80A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ILE A 704
ALA A 716
VAL A 699
LEU A 645
MET A 620
 None
 1.07A 2g78A-2zzgA:
undetectable		 2g78A-2zzgA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 PHE X  48
LEU X  52
THR X 305
VAL X 230
LEU X 280
 None
 1.03A 2g78A-3b8aX:
undetectable		 2g78A-3b8aX:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		5 LEU A 370
ALA A 333
VAL A 347
ARG A 487
LEU A 491
 None
 1.12A 2g78A-3bf0A:
undetectable		 2g78A-3bf0A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		5 PHE A 135
LEU A 116
ALA A 120
VAL A  31
LEU A  96
 None
 1.13A 2g78A-3cm5A:
undetectable		 2g78A-3cm5A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 LEU A 178
ILE A  82
ALA A 158
VAL A 239
MET A 260
 None
 0.98A 2g78A-3d7rA:
undetectable		 2g78A-3d7rA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		5 PHE A 266
ILE A 321
ALA A 322
THR A 400
THR A 388
 None
 1.17A 2g78A-3dknA:
undetectable		 2g78A-3dknA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 PHE A 122
ILE A 219
THR A 112
THR A 141
VAL A 142
 None
 1.08A 2g78A-3do5A:
undetectable		 2g78A-3do5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1t UNCHARACTERIZED
PROTEIN Q9I3C8_PSEAE

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 LEU A  17
THR A 116
THR A  71
VAL A  72
LEU A  86
 None
 1.09A 2g78A-3f1tA:
2.0		 2g78A-3f1tA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A 125
ILE A 189
ALA A 190
THR A  24
LEU A 139
 None
 1.06A 2g78A-3ibhA:
undetectable		 2g78A-3ibhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		5 LEU A 309
ILE A  87
ALA A  86
THR A 105
VAL A 303
 None
 1.14A 2g78A-3k2gA:
undetectable		 2g78A-3k2gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		5 PHE A 136
LEU A 140
ILE A 147
ALA A  25
LEU A 103
 None
 0.97A 2g78A-3kzaA:
3.8		 2g78A-3kzaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A  16
ILE A 186
ALA A 187
THR A  39
VAL A  32
 None
 1.16A 2g78A-3l2zA:
undetectable		 2g78A-3l2zA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 340
ALA A 337
THR A  29
VAL A   6
VAL A  17
 None
 1.11A 2g78A-3ladA:
undetectable		 2g78A-3ladA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md3 NUCLEAR AND
CYTOPLASMIC
POLYADENYLATED
RNA-BINDING PROTEIN
PUB1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 ILE A 130
ALA A 131
VAL A  97
VAL A 120
LEU A  82
 None
 1.17A 2g78A-3md3A:
undetectable		 2g78A-3md3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf5 NUCLEOPORIN NUP116

([Candida]
glabrata) 		PF04096
(Nucleoporin2) 		5 LEU A1008
ILE A 977
VAL A 955
ARG A 990
LEU A 985
 None
 1.12A 2g78A-3nf5A:
undetectable		 2g78A-3nf5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 348
ILE A 372
ALA A 371
THR A 303
VAL A 356
 None
 1.11A 2g78A-3nvaA:
undetectable		 2g78A-3nvaA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 445
ILE A 450
ALA A 451
VAL A 506
ARG A 437
 None
 1.11A 2g78A-3nvaA:
undetectable		 2g78A-3nvaA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		5 PHE A 142
ILE A 138
THR A  82
VAL A 127
LEU A 166
 None
 1.00A 2g78A-3p94A:
undetectable		 2g78A-3p94A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A 152
LEU A 156
ILE A 163
ALA A  41
LEU A 119
 None
 1.00A 2g78A-3ph5A:
undetectable		 2g78A-3ph5A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svi TYPE III EFFECTOR
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 6 PHE A 167
LEU A 171
ILE A 206
ALA A 205
LEU A 178
MET A 176
 None
 1.44A 2g78A-3sviA:
undetectable		 2g78A-3sviA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjy EFFECTOR PROTEIN
HOPAB3

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 6 PHE A 167
LEU A 171
ILE A 206
ALA A 205
LEU A 178
MET A 176
 None
 1.44A 2g78A-3tjyA:
undetectable		 2g78A-3tjyA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 PHE A 764
LEU A 760
ILE A 663
ALA A 660
THR A 831
VAL A 799
 None
 1.44A 2g78A-3v5qA:
undetectable		 2g78A-3v5qA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A2243
ALA A2244
THR A2284
VAL A2288
ARG A2530
 None
None
ADP  A9002 (-3.1A)
None
None
 1.12A 2g78A-3vkgA:
undetectable		 2g78A-3vkgA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		5 LEU A  56
ILE A  71
ALA A  68
THR A 130
VAL A 124
 None
 1.07A 2g78A-3w25A:
undetectable		 2g78A-3w25A:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
THR A  40
ARG A 106
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-3.8A)
None
None
None
 1.07A 2g78A-3wbgA:
19.2		 2g78A-3wbgA:
40.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.01A 2g78A-3wfoA:
undetectable		 2g78A-3wfoA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.10A 2g78A-3wfpA:
undetectable		 2g78A-3wfpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A  23
ALA A  49
THR A  46
VAL A 289
LEU A 271
 None
 1.02A 2g78A-3zz1A:
undetectable		 2g78A-3zz1A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0x TRANSCRIPTION FACTOR
FAPR

(Staphylococcus
aureus) 		PF03061
(4HBT) 		5 LEU A 114
ILE A 108
ALA A 109
VAL A 150
ARG A  56
 None
 1.03A 2g78A-4a0xA:
2.9		 2g78A-4a0xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		5 PHE A 996
ILE A 907
VAL A 928
ARG A1093
LEU A1025
 None
 0.94A 2g78A-4bkwA:
undetectable		 2g78A-4bkwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A  85
ILE A 656
VAL A 573
VAL A 582
LEU A 281
 None
 1.13A 2g78A-4ddwA:
undetectable		 2g78A-4ddwA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		5 PHE A 446
LEU A 475
ILE A 484
VAL A 427
VAL A 385
 None
 1.11A 2g78A-4fe9A:
undetectable		 2g78A-4fe9A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha7 2,5-DIAMINO-6-RIBOSY
LAMINO-4(3H)-PYRIMID
INONE 5'-PHOSPHATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01872
(RibD_C) 		5 LEU A 168
ILE A 149
ALA A 148
VAL A 134
LEU A  87
 None
 1.15A 2g78A-4ha7A:
undetectable		 2g78A-4ha7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 PHE A  19
LEU A  23
ILE A 237
ALA A 238
THR A  46
 None
 1.14A 2g78A-4ixoA:
undetectable		 2g78A-4ixoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		5 LEU A  96
ILE A  89
THR A  41
VAL A  83
VAL A  78
 None
 0.98A 2g78A-4jjpA:
undetectable		 2g78A-4jjpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 170
ILE A 211
ALA A 212
VAL A 241
LEU A 114
 None
 1.05A 2g78A-4k17A:
undetectable		 2g78A-4k17A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 386
ILE A 429
THR A 375
LEU A 354
MET A 357
 None
 1.17A 2g78A-4k17A:
undetectable		 2g78A-4k17A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 PHE A 144
LEU A  62
ALA A  91
VAL A  97
VAL A  71
 None
 0.95A 2g78A-4k6mA:
undetectable		 2g78A-4k6mA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A  33
VAL A  71
VAL A  30
ARG A 271
LEU A 267
 None
 1.16A 2g78A-4lisA:
undetectable		 2g78A-4lisA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrv DNA SULFUR
MODIFICATION PROTEIN
DNDE

(Escherichia
coli) 		PF08870
(DndE) 		5 LEU A  18
ILE A  27
ALA A  32
THR A  75
VAL A  99
 None
 1.08A 2g78A-4lrvA:
undetectable		 2g78A-4lrvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6v CYSTATIN-B

(Homo sapiens) 		no annotation 5 PHE 2  38
ILE 2  19
ALA 2  20
VAL 2  69
VAL 2  65
 None
 1.10A 2g78A-4n6v2:
2.1		 2g78A-4n6v2:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pib INCLUSION BODY
PROTEIN

(Burkholderia
thailandensis) 		PF12306
(PixA) 		5 PHE A 159
LEU A 112
ALA A 148
THR A  23
VAL A 187
 None
 1.14A 2g78A-4pibA:
undetectable		 2g78A-4pibA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 6 PHE B  57
LEU B  71
ILE B  18
ALA B  75
VAL B  45
MET B  60
 None
 1.22A 2g78A-4pl2B:
undetectable		 2g78A-4pl2B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn3 HAD SUPERFAMILY
HYDROLASE

(Geobacter
sulfurreducens) 		PF13419
(HAD_2) 		5 PHE A 135
LEU A 103
ILE A 207
THR A 116
VAL A 171
 None
 1.17A 2g78A-4rn3A:
undetectable		 2g78A-4rn3A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 LEU A 100
ALA A  50
THR A 219
VAL A 338
VAL A 133
 None
 1.12A 2g78A-4u9cA:
2.4		 2g78A-4u9cA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1

(Homo sapiens) 		PF02214
(BTB_2) 		5 PHE A  70
LEU A  59
THR A  78
VAL A  47
VAL A  43
 None
 1.01A 2g78A-4uijA:
undetectable		 2g78A-4uijA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 430
ILE A 407
ALA A 403
VAL A 340
VAL A 377
 None
 1.10A 2g78A-4ywoA:
undetectable		 2g78A-4ywoA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A  28
ILE A  90
THR A 119
VAL A 117
VAL A 363
 None
 1.11A 2g78A-5d01A:
undetectable		 2g78A-5d01A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 ILE A  44
ALA A  45
VAL A 396
VAL A   9
LEU A 422
 None
 1.15A 2g78A-5dqpA:
undetectable		 2g78A-5dqpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		5 PHE A 430
LEU A 434
ALA A 276
VAL A 318
VAL A 445
 None
 1.01A 2g78A-5du9A:
undetectable		 2g78A-5du9A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epa SNOK

(Streptomyces
nogalater) 		PF05721
(PhyH) 		5 LEU A  95
ILE A  88
THR A   8
VAL A  32
VAL A  27
 None
 1.15A 2g78A-5epaA:
undetectable		 2g78A-5epaA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		5 LEU A 439
ILE A 434
THR A 414
VAL A 417
VAL A 493
 None
 1.08A 2g78A-5f8pA:
undetectable		 2g78A-5f8pA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		5 LEU A 129
ILE A 126
ALA A 127
VAL A  67
VAL A  75
 None
 1.10A 2g78A-5jr4A:
undetectable		 2g78A-5jr4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		5 ILE A 470
VAL A 455
VAL A 402
ARG A 406
LEU A 416
 None
 1.14A 2g78A-5tj3A:
undetectable		 2g78A-5tj3A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 LEU A 947
ILE A 942
VAL A 939
VAL A 996
LEU A1024
 None
 1.14A 2g78A-5ve8A:
undetectable		 2g78A-5ve8A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF

(Homo sapiens) 		no annotation 5 PHE A 109
LEU A 113
THR A 146
ARG A 168
LEU A 136
 None
 1.14A 2g78A-5vykA:
undetectable		 2g78A-5vykA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 694
LEU A 698
ILE A 675
THR A 614
VAL A 621
 None
 1.14A 2g78A-5xgeA:
undetectable		 2g78A-5xgeA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		5 PHE A 385
LEU A 389
ILE A 449
ALA A 448
LEU A 338
 None
 1.08A 2g78A-5xjjA:
undetectable		 2g78A-5xjjA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr1 C-TERMINAL PEPTIDE
OF INTEGRIN
BETA-2,FILAMIN-A
IG21 DOMAIN

(Homo sapiens) 		no annotation 5 PHE A  46
LEU A  35
ALA A  30
THR A   7
VAL A  94
 None
 1.13A 2g78A-5xr1A:
undetectable		 2g78A-5xr1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S21
40S RIBOSOMAL
PROTEIN SA

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		5 LEU V  78
ILE V  71
ALA V  72
VAL V  52
LEU A 183
 None
 1.07A 2g78A-5xyiV:
undetectable		 2g78A-5xyiV:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 6 LEU A 298
ILE A 370
ALA A 369
VAL A 378
VAL A 329
LEU A 862
 None
 1.34A 2g78A-5yx9A:
undetectable		 2g78A-5yx9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 PHE B 417
LEU B 358
ILE B 405
ALA B 404
LEU B 351
 None
 1.14A 2g78A-5zvtB:
undetectable		 2g78A-5zvtB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 5 ILE U 208
VAL U 290
VAL U 161
LEU U 406
MET U 410
 None
 1.06A 2g78A-5zvtU:
undetectable		 2g78A-5zvtU:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 PHE A 246
LEU A 238
ALA A 242
VAL A 195
VAL A 214
 None
 1.14A 2g78A-6brdA:
undetectable		 2g78A-6brdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 5 PHE A 834
LEU A 783
ILE A 778
ALA A 779
VAL A 814
 None
 1.17A 2g78A-6brsA:
undetectable		 2g78A-6brsA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 ILE A 157
THR A 171
VAL A 274
VAL A 153
ARG A  36
 None
None
None
None
FAD  A 501 (-3.8A)
 1.10A 2g78A-6bz0A:
undetectable		 2g78A-6bz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 5 ALA A 141
THR A  72
VAL A  87
LEU A 151
MET A  57
 None
 1.13A 2g78A-6gngA:
undetectable		 2g78A-6gngA:
undetectable