SIMILAR PATTERNS OF AMINO ACIDS FOR 2G72_A_SAMA2001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 TYR A 265
LEU A 269
HIS A 289
ALA A 249
VAL A 257
 None
None
G  B  34 ( 4.4A)
None
None
 1.39A 2g72A-1h3eA:
2.0		 2g72A-1h3eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ASP A 430
VAL A 433
ALA A 360
VAL A 279
TYR A 293
 None
 1.41A 2g72A-1jx2A:
undetectable		 2g72A-1jx2A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 THR A 369
LEU A 363
ASP A 352
VAL A 349
CYH A 388
 None
 1.28A 2g72A-1n21A:
undetectable		 2g72A-1n21A:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		12 TYR A  27
THR A  83
PHE A 102
LEU A 103
ASP A 158
VAL A 159
HIS A 160
ALA A 181
PHE A 182
CYH A 183
VAL A 187
TYR A 222
 SAH  A2002 (-3.6A)
SAH  A2002 (-2.9A)
SAH  A2002 (-4.4A)
SAH  A2002 (-3.9A)
SAH  A2002 (-3.6A)
SAH  A2002 (-3.5A)
SAH  A2002 (-4.1A)
SAH  A2002 (-3.3A)
IDI  A3003 ( 3.4A)
SAH  A2002 (-3.4A)
SAH  A2002 (-4.3A)
IDI  A3003 (-3.8A)
 0.23A 2g72A-1n7jA:
47.0		 2g72A-1n7jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 411
VAL A 345
HIS A 606
PHE A 618
VAL A 610
 None
 1.36A 2g72A-1qjmA:
undetectable		 2g72A-1qjmA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		5 PHE A 101
LEU A  60
ALA A  20
CYH A  18
VAL A  14
 None
 1.34A 2g72A-1tdhA:
undetectable		 2g72A-1tdhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 112
ASP A 107
HIS A 105
ALA A  26
PHE A  27
 None
 1.42A 2g72A-1tf0A:
undetectable		 2g72A-1tf0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 VAL A  57
ALA A 473
PHE A 477
CYH A 475
VAL A 481
 None
 1.16A 2g72A-1tmoA:
undetectable		 2g72A-1tmoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 363
ASP A 237
VAL A 177
ALA A 249
VAL A 350
 LEU  A 363 ( 0.6A)
ASP  A 237 ( 0.5A)
VAL  A 177 ( 0.6A)
ALA  A 249 ( 0.0A)
VAL  A 350 ( 0.6A)
 1.23A 2g72A-1wqaA:
undetectable		 2g72A-1wqaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		5 LEU A 132
ASP A  21
ALA A  76
PHE A  61
CYH A  74
 None
 1.38A 2g72A-1yleA:
undetectable		 2g72A-1yleA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		5 TYR A 117
PHE A 112
VAL A 110
ALA A 140
VAL A 115
 None
 1.42A 2g72A-1zjrA:
undetectable		 2g72A-1zjrA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  11
THR A  67
PHE A  86
ASP A 142
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.45A 2g72A-2a14A:
36.8		 2g72A-2a14A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		5 THR A 154
LEU A  30
ASP A 132
ALA A  45
VAL A  89
 None
 1.36A 2g72A-2amlA:
undetectable		 2g72A-2amlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A 178
VAL A  63
ALA A 169
CYH A 171
VAL A  42
 MLY  A 179 ( 4.3A)
None
MLY  A 187 ( 3.2A)
None
None
 1.45A 2g72A-2ftzA:
undetectable		 2g72A-2ftzA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9f PEPTIDE N-GLYCANASE

(Mus musculus) 		PF04721
(PAW) 		5 TYR A 501
THR A 568
LEU A 492
ALA A 613
VAL A 518
 None
 1.36A 2g72A-2g9fA:
undetectable		 2g72A-2g9fA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjn MAINTENANCE OF
PLOIDY PROTEIN MOB1

(Saccharomyces
cerevisiae) 		PF03637
(Mob1_phocein) 		5 TYR A 259
LEU A 279
VAL A 308
PHE A 289
CYH A 287
 None
 1.31A 2g72A-2hjnA:
undetectable		 2g72A-2hjnA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  12
THR A  68
ASP A 143
VAL A 144
CYH A 166
TYR A 205
 SAH  A4001 (-3.8A)
SAH  A4001 (-3.6A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.6A)
SAH  A4001 ( 3.8A)
None
 0.41A 2g72A-2i62A:
37.1		 2g72A-2i62A:
37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  11
THR A  67
ASP A 142
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-3.5A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.50A 2g72A-2iipA:
36.3		 2g72A-2iipA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inf UROPORPHYRINOGEN
DECARBOXYLASE

(Bacillus
subtilis) 		PF01208
(URO-D) 		5 THR A 156
LEU A 180
ASP A 187
PHE A 149
VAL A 226
 None
 1.41A 2g72A-2infA:
undetectable		 2g72A-2infA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioj HYPOTHETICAL PROTEIN
AF_1212

(Archaeoglobus
fulgidus) 		PF07085
(DRTGG) 		5 THR A 257
LEU A 314
VAL A 209
CYH A 276
VAL A 230
 None
 1.40A 2g72A-2iojA:
undetectable		 2g72A-2iojA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mkk CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF16367
(RRM_7) 		5 LEU A 361
VAL A 396
ALA A 410
PHE A 412
VAL A 354
 None
 1.39A 2g72A-2mkkA:
undetectable		 2g72A-2mkkA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 LEU A  18
VAL A 246
ALA A 285
CYH A 295
VAL A 312
 None
 1.34A 2g72A-2nqnA:
undetectable		 2g72A-2nqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 LEU A 161
ASP A 139
ALA A 261
PHE A  52
VAL A   6
 None
 1.41A 2g72A-2nwhA:
3.9		 2g72A-2nwhA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PHE X 159
LEU X 156
ASP X 229
HIS X 170
CYH X 100
 None
 1.30A 2g72A-2pmoX:
undetectable		 2g72A-2pmoX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12

(Homo sapiens) 		PF00644
(PARP) 		5 TYR A 670
VAL A 674
ALA A 573
CYH A 575
VAL A 532
 None
None
CIT  A 801 ( 4.4A)
None
None
 1.17A 2g72A-2pqfA:
undetectable		 2g72A-2pqfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re3 UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06938
(DUF1285) 		5 LEU A  79
VAL A 117
ALA A  45
PHE A  51
VAL A  63
 None
 1.45A 2g72A-2re3A:
undetectable		 2g72A-2re3A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 LEU A 473
VAL A 136
ALA A 119
PHE A 122
VAL A 126
 None
 1.36A 2g72A-2x98A:
undetectable		 2g72A-2x98A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ASP A 125
VAL A 122
ALA A  88
CYH A 170
VAL A 167
 None
 1.44A 2g72A-2xymA:
undetectable		 2g72A-2xymA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		5 PHE A 215
VAL A 220
ALA A 285
PHE A 211
TYR A 244
 None
 1.32A 2g72A-2yu1A:
undetectable		 2g72A-2yu1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 TYR A 210
LEU A 208
ASP A  79
VAL A  82
ALA A 101
 None
 1.32A 2g72A-2yysA:
2.0		 2g72A-2yysA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 PHE A 240
LEU A 256
ASP A 239
VAL A 238
ALA A 225
 None
 1.30A 2g72A-3a9xA:
undetectable		 2g72A-3a9xA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		5 PHE A 819
ASP A 795
VAL A 792
ALA A 772
TYR A 853
 None
 1.32A 2g72A-3bdlA:
undetectable		 2g72A-3bdlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		5 THR A  28
ASP A 155
VAL A 126
ALA A  58
VAL A  40
 None
 1.13A 2g72A-3bkxA:
8.8		 2g72A-3bkxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		5 PHE A  47
LEU A  93
ASP A  65
VAL A  66
VAL A  41
 None
 1.08A 2g72A-3bwhA:
undetectable		 2g72A-3bwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		5 THR C 139
VAL C 119
ALA C  82
PHE C  80
VAL C 133
 None
 1.30A 2g72A-3cjiC:
undetectable		 2g72A-3cjiC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 VAL A  77
ALA A  43
PHE A  47
CYH A  45
VAL A  56
 None
 1.38A 2g72A-3co1A:
undetectable		 2g72A-3co1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9r KETOSTEROID
ISOMERASE-LIKE
PROTEIN

(Pectobacterium
atrosepticum) 		PF12680
(SnoaL_2) 		5 THR A  34
PHE A  86
LEU A 113
VAL A  77
ALA A  18
 None
 1.41A 2g72A-3d9rA:
undetectable		 2g72A-3d9rA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 187
VAL A 227
HIS A 265
ALA A 166
VAL A 269
 None
None
None
HEM  A 500 ( 4.4A)
None
 1.36A 2g72A-3dbgA:
undetectable		 2g72A-3dbgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 LEU A 180
ASP A 125
VAL A  33
HIS A  29
ALA A 115
 None
 1.15A 2g72A-3dtoA:
undetectable		 2g72A-3dtoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		5 THR A 183
LEU A 175
PHE A 130
CYH A 159
VAL A 161
 None
 1.27A 2g72A-3dxiA:
undetectable		 2g72A-3dxiA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3q T-CELL RECEPTOR
ALPHA CHAIN V REGION
PHDS58

(Mus musculus) 		no annotation 5 TYR D  88
LEU D  75
VAL D  12
VAL D 112
TYR D  38
 None
 1.45A 2g72A-3e3qD:
undetectable		 2g72A-3e3qD:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejf NON-STRUCTURAL
PROTEIN 3

(Avian
coronavirus) 		PF01661
(Macro) 		5 ASP A 117
VAL A 116
CYH A  89
VAL A  79
TYR A  64
 None
 0.98A 2g72A-3ejfA:
undetectable		 2g72A-3ejfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 THR A 955
LEU A1066
VAL A1107
ALA A1153
VAL A1081
 None
 1.22A 2g72A-3fawA:
undetectable		 2g72A-3fawA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g33 CCND3 PROTEIN

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 THR B 235
PHE B 163
LEU B  31
ASP B  24
HIS B 166
 None
 1.34A 2g72A-3g33B:
undetectable		 2g72A-3g33B:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe) 		PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		5 ASP E  24
VAL E  22
HIS E  23
PHE E  59
VAL E  29
 None
 1.45A 2g72A-3h0gE:
undetectable		 2g72A-3h0gE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		5 THR A  91
ASP A   9
HIS A 279
ALA A 125
VAL A 107
 None
 1.43A 2g72A-3h74A:
undetectable		 2g72A-3h74A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfs ANTHOCYANIDIN
REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		5 VAL A 113
HIS A  86
ALA A  76
PHE A  64
VAL A  15
 None
 1.38A 2g72A-3hfsA:
5.3		 2g72A-3hfsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 298
LEU A 247
ASP A 221
VAL A 195
ALA A 145
 None
 1.35A 2g72A-3i6eA:
undetectable		 2g72A-3i6eA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihw CENTG3

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 140
ASP A 244
VAL A 241
ALA A 106
VAL A 161
 None
 1.43A 2g72A-3ihwA:
undetectable		 2g72A-3ihwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxa CONTACTIN 4

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 TYR A 293
THR A 241
PHE A 231
LEU A 245
PHE A 312
 None
 1.44A 2g72A-3jxaA:
undetectable		 2g72A-3jxaA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 213
VAL A 173
ALA A 222
CYH A 221
VAL A 162
 None
 1.36A 2g72A-3k30A:
undetectable		 2g72A-3k30A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5z FEM-3 MRNA-BINDING
FACTOR 2

(Caenorhabditis
elegans) 		PF00806
(PUF) 		5 THR A 278
VAL A 347
ALA A 317
CYH A 319
VAL A 365
 None
 1.14A 2g72A-3k5zA:
undetectable		 2g72A-3k5zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 511
LEU A 532
VAL A 584
ALA A 588
VAL A 572
 None
 1.21A 2g72A-3mosA:
2.2		 2g72A-3mosA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 PHE A 341
LEU A 335
ASP A 294
VAL A 295
ALA A 286
 None
 1.32A 2g72A-3qfhA:
undetectable		 2g72A-3qfhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 THR A 396
PHE A 341
LEU A 335
ASP A 294
VAL A 295
 None
 1.37A 2g72A-3qfhA:
undetectable		 2g72A-3qfhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		5 PHE A 285
VAL A 290
ALA A 355
PHE A 281
TYR A 314
 E67  A 707 (-4.3A)
None
None
None
None
 1.31A 2g72A-3u78A:
undetectable		 2g72A-3u78A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		5 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.34A 2g72A-3wsuA:
undetectable		 2g72A-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 THR A 121
PHE A 187
VAL A 230
ALA A  92
VAL A 189
 None
 1.24A 2g72A-4da9A:
3.7		 2g72A-4da9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		5 THR A 291
LEU A 266
ALA A 237
CYH A 253
VAL A 315
 None
 1.28A 2g72A-4ed9A:
undetectable		 2g72A-4ed9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 130
VAL A 279
HIS A 313
ALA A 113
VAL A 312
 None
 1.41A 2g72A-4h19A:
undetectable		 2g72A-4h19A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU S 109
VAL S 145
ALA S 119
PHE S  73
VAL S  76
 None
 1.20A 2g72A-4ko2S:
undetectable		 2g72A-4ko2S:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 TYR A  70
LEU A 203
VAL A  12
HIS A  11
ALA A 102
 None
 1.40A 2g72A-4lbwA:
undetectable		 2g72A-4lbwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2

(Homo sapiens) 		PF00001
(7tm_1) 		5 TYR A 440
LEU A  62
ASP A  69
PHE A 119
TYR A 206
 None
 1.32A 2g72A-4mqtA:
undetectable		 2g72A-4mqtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		5 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.35A 2g72A-4p9kA:
undetectable		 2g72A-4p9kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ASP A 281
VAL A 278
HIS A  46
ALA A 123
PHE A 117
 None
 1.30A 2g72A-4pddA:
undetectable		 2g72A-4pddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.36A 2g72A-4pdhA:
undetectable		 2g72A-4pdhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 TYR A 387
THR A 461
LEU A 429
ALA A 438
TYR A 391
 None
 1.12A 2g72A-4pqkA:
undetectable		 2g72A-4pqkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ASP A 296
VAL A 297
HIS A 298
PHE A 366
VAL A 322
 None
 1.42A 2g72A-4q0gA:
undetectable		 2g72A-4q0gA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfb CT263

(Chlamydia
trachomatis) 		no annotation 5 THR A  85
LEU A 114
VAL A  91
ALA A  70
VAL A 106
 None
 1.19A 2g72A-4qfbA:
undetectable		 2g72A-4qfbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		5 PHE A 215
VAL A 220
ALA A 285
PHE A 211
TYR A 244
 None
 1.38A 2g72A-4qx8A:
undetectable		 2g72A-4qx8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN

(Acinetobacter
baumannii) 		no annotation 5 TYR A 108
LEU A 140
ASP A 143
VAL A 104
ALA A 170
 None
 1.41A 2g72A-4rlbA:
undetectable		 2g72A-4rlbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 149
ASP A 156
VAL A 155
PHE A 185
VAL A 191
 None
 1.30A 2g72A-4wwhA:
undetectable		 2g72A-4wwhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 337
VAL A 282
ALA A 344
VAL A 280
TYR A 368
 None
 1.40A 2g72A-4wz9A:
undetectable		 2g72A-4wz9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		5 THR A 111
PHE A 314
LEU A 349
ALA A 310
VAL A 271
 None
 1.38A 2g72A-4yycA:
undetectable		 2g72A-4yycA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A2415
LEU A2475
ALA A2391
PHE A2390
VAL A2563
 None
 0.93A 2g72A-4z37A:
undetectable		 2g72A-4z37A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 647
LEU A 706
ALA A 623
PHE A 622
VAL A 794
 None
 0.90A 2g72A-4zdnA:
undetectable		 2g72A-4zdnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 PHE A 266
ASP A 209
VAL A 210
ALA A 288
CYH A 286
 None
SAH  A 401 ( 4.6A)
None
None
None
 1.37A 2g72A-5cvvA:
12.5		 2g72A-5cvvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 THR A 137
LEU A 142
HIS A 470
ALA A 447
TYR A 458
 None
 1.34A 2g72A-5do7A:
undetectable		 2g72A-5do7A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 LEU A  50
ASP A  80
HIS A  37
ALA A  67
VAL A  39
 None
 1.37A 2g72A-5esrA:
undetectable		 2g72A-5esrA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 THR A 210
ASP A  82
VAL A  83
VAL A 133
TYR A 175
 NAP  A 301 (-3.1A)
NAP  A 301 (-3.7A)
NAP  A 301 (-3.5A)
None
NAP  A 301 (-4.6A)
 1.38A 2g72A-5feuA:
6.7		 2g72A-5feuA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		5 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.26A 2g72A-5g4lA:
6.3		 2g72A-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itq ENDONUCLEASE 8-LIKE
1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		5 PHE A 101
LEU A  60
ALA A  20
CYH A  18
VAL A  14
 None
 1.34A 2g72A-5itqA:
undetectable		 2g72A-5itqA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgj UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF01209
(Ubie_methyltran) 		5 LEU A  29
ASP A  36
VAL A  35
ALA A  59
VAL A  63
 None
 1.43A 2g72A-5jgjA:
9.2		 2g72A-5jgjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwr CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 PHE A 195
VAL A 151
ALA A 169
PHE A 166
VAL A 161
 None
 1.35A 2g72A-5jwrA:
2.5		 2g72A-5jwrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy7 MALTOKINASE

(Mycolicibacterium
smegmatis) 		PF01636
(APH) 		5 THR I 313
LEU I 236
VAL I 243
HIS I 244
ALA I 173
 None
 1.41A 2g72A-5jy7I:
undetectable		 2g72A-5jy7I:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Homo sapiens) 		PF00076
(RRM_1)
PF08662
(eIF2A) 		5 THR B 571
PHE B 525
ASP B 542
VAL B 541
ALA B 529
 None
 1.36A 2g72A-5k1hB:
undetectable		 2g72A-5k1hB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 THR A 250
PHE A 238
LEU A 221
ALA A 322
VAL A 367
 None
None
None
NDP  A 601 (-3.5A)
None
 1.36A 2g72A-5ktkA:
6.1		 2g72A-5ktkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		5 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.41A 2g72A-5lgdA:
undetectable		 2g72A-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 TYR B 295
LEU B 345
PHE C   7
VAL B 293
TYR C   3
 None
 1.33A 2g72A-5n28B:
undetectable		 2g72A-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2k BRIAKINUMAB FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 TYR G  87
LEU G  48
VAL G  18
ALA G  81
VAL G 108
 None
 1.39A 2g72A-5n2kG:
undetectable		 2g72A-5n2kG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		5 LEU A 209
ASP A 202
ALA A 262
PHE A 164
VAL A 255
 None
 1.42A 2g72A-5o5oA:
undetectable		 2g72A-5o5oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		5 LEU A 297
HIS A 252
ALA A 344
PHE A 369
VAL A 285
 None
 1.42A 2g72A-5tjrA:
3.0		 2g72A-5tjrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 PHE A 196
LEU A 220
VAL A 127
ALA A  10
VAL A 446
 None
 1.23A 2g72A-5u6sA:
undetectable		 2g72A-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		5 PHE 8 318
LEU 8 363
VAL 8 404
ALA 8 310
PHE 8 313
 None
 1.31A 2g72A-5udb8:
undetectable		 2g72A-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woq TRANSCRIPTIONAL
REGULATOR CLGR

(Mycolicibacterium
smegmatis) 		PF13560
(HTH_31) 		5 ASP A  70
VAL A  67
ALA A  55
CYH A  57
VAL A  62
 None
 1.16A 2g72A-5woqA:
undetectable		 2g72A-5woqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 TYR A 651
PHE A 665
LEU A 659
VAL A 688
ALA A 607
 None
 1.26A 2g72A-5z06A:
undetectable		 2g72A-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.30A 2g72A-5zb3A:
undetectable		 2g72A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhn METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER WITH
PHYTOCHROME SENSOR

(Nostoc
punctiforme) 		no annotation 5 TYR A 668
LEU A 714
ASP A 657
HIS A 659
ALA A 699
 CYC  A 800 (-3.9A)
None
CYC  A 800 (-2.1A)
CYC  A 800 (-3.6A)
None
 1.12A 2g72A-6bhnA:
undetectable		 2g72A-6bhnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 5 PHE A 350
LEU A 464
ASP A 354
ALA A 454
VAL A 149
 None
None
None
HEM  A 600 (-3.4A)
None
 1.39A 2g72A-6c93A:
undetectable		 2g72A-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.18A 2g72A-6fa5A:
2.1		 2g72A-6fa5A:
undetectable