SIMILAR PATTERNS OF AMINO ACIDS FOR 2G70_B_SAMB2002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 TYR A  57
GLY A 113
THR A 133
ASN A 135
 None
 0.89A 2g70B-1c7jA:
undetectable		 2g70B-1c7jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		4 TYR A  71
GLY A 138
THR A  48
ASN A 142
 None
 1.06A 2g70B-1cp9A:
undetectable		 2g70B-1cp9A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 TYR A 191
GLY A 317
THR A 292
ASP A 318
 None
 1.07A 2g70B-1csjA:
undetectable		 2g70B-1csjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 TYR A 284
GLY A 315
THR A 313
ASP A  56
 None
None
None
CA  A 803 (-2.5A)
 1.05A 2g70B-1cvmA:
undetectable		 2g70B-1cvmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 TYR A 462
GLY A 457
THR A 455
TYR A 438
 None
 0.97A 2g70B-1fokA:
undetectable		 2g70B-1fokA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 TYR A 108
GLY A  92
THR A  81
ASP A  91
 None
 1.07A 2g70B-1gw1A:
undetectable		 2g70B-1gw1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 TYR A  82
GLY A 163
THR A 113
ASP A 166
 None
 1.06A 2g70B-1hjuA:
undetectable		 2g70B-1hjuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu4 MICROBIAL
TRANSGLUTAMINASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		4 TYR A 256
TYR A 198
GLY A  66
THR A  68
 None
 1.08A 2g70B-1iu4A:
undetectable		 2g70B-1iu4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 TYR A 183
GLY A 172
THR A 185
TYR A 187
ASN A 242
 None
 1.35A 2g70B-1lrwA:
undetectable		 2g70B-1lrwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 TYR A  86
GLY A  89
ASP A  90
ASN A 364
 None
 0.93A 2g70B-1m2wA:
3.1		 2g70B-1m2wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		5 GLY A 267
THR A 236
TYR A 234
ASP A 298
ASN A 266
 None
 1.42A 2g70B-1mpoA:
undetectable		 2g70B-1mpoA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  35
TYR A  40
GLY A  81
THR A  83
TYR A  85
ASP A 101
ASN A 106
 SAH  A2002 ( 4.4A)
SAH  A2002 (-4.6A)
SAH  A2002 (-3.0A)
SAH  A2002 (-2.9A)
SAH  A2002 (-4.6A)
SAH  A2002 (-3.1A)
SAH  A2002 (-3.6A)
 0.21A 2g70B-1n7jA:
46.5		 2g70B-1n7jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8r GUANYLIN

(Homo sapiens) 		PF02058
(Guanylin) 		4 GLY A  81
THR A  82
TYR A  88
ASP A  79
 None
 1.00A 2g70B-1o8rA:
undetectable		 2g70B-1o8rA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 TYR A  58
GLY A  23
ASP A  24
ASN A  25
 None
 1.08A 2g70B-1qs8A:
undetectable		 2g70B-1qs8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 TYR A 224
GLY A 140
TYR A 210
ASP A  60
 None
 0.94A 2g70B-1ru3A:
2.6		 2g70B-1ru3A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLY A 377
THR A 389
TYR A 421
ASN A 376
 None
 0.98A 2g70B-1ryyA:
undetectable		 2g70B-1ryyA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		4 TYR A  91
GLY A  97
TYR A 145
ASP A 112
 None
None
None
CA  A2184 (-2.5A)
 1.02A 2g70B-1sddA:
undetectable		 2g70B-1sddA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 TYR A  59
GLY A  78
THR A  77
ASP A  79
 None
 0.78A 2g70B-1sivA:
undetectable		 2g70B-1sivA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp3 CYTOCHROME C,
PUTATIVE

(Shewanella
oneidensis) 		PF11783
(Cytochrome_cB)
PF13435
(Cytochrome_C554) 		4 TYR A 314
GLY A 317
ASP A 321
ASN A 292
 None
 1.08A 2g70B-1sp3A:
undetectable		 2g70B-1sp3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vic 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Haemophilus
influenzae) 		PF02348
(CTP_transf_3) 		4 TYR A 191
GLY A  75
THR A  76
TYR A 199
 None
 0.92A 2g70B-1vicA:
undetectable		 2g70B-1vicA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.08A 2g70B-1w6sA:
undetectable		 2g70B-1w6sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 GLY A 431
THR A 433
TYR A 435
ASN A 310
 None
 0.71A 2g70B-1wkyA:
undetectable		 2g70B-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii;
Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A)
PF02310
(B12-binding)
PF16554
(OAM_dimer) 		4 TYR B 146
GLY A 204
THR A 185
TYR A 207
 B12  B 800 (-4.2A)
None
None
None
 0.96A 2g70B-1xrsB:
undetectable		 2g70B-1xrsB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		4 GLY A 215
THR A 211
TYR A 207
ASP A 216
 None
 1.07A 2g70B-1ztmA:
undetectable		 2g70B-1ztmA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 TYR A  20
THR A  67
TYR A  25
ASP A  61
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
None
 0.87A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
 0.32A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 277
THR A 114
TYR A 112
ASP A 279
 None
None
FAD  A 480 (-3.4A)
None
 1.05A 2g70B-2a8xA:
2.3		 2g70B-2a8xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 TYR A 563
GLY A 576
TYR A 249
ASN A 578
 None
 1.06A 2g70B-2d5wA:
undetectable		 2g70B-2d5wA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  21
TYR A  26
GLY A  66
THR A  68
TYR A  70
ASP A  86
ASN A  91
 SAH  A4001 (-4.5A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.2A)
SAH  A4001 (-3.6A)
SAH  A4001 (-4.3A)
SAH  A4001 (-2.9A)
SAH  A4001 (-3.9A)
 0.32A 2g70B-2i62A:
37.0		 2g70B-2i62A:
37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
 0.34A 2g70B-2iipA:
36.6		 2g70B-2iipA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		4 TYR A 237
TYR A 265
GLY A 270
ASP A 271
 None
 0.88A 2g70B-2j7aA:
undetectable		 2g70B-2j7aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		5 GLY A 277
THR A 236
TYR A 234
ASP A 308
ASN A 276
 None
 1.40A 2g70B-2mprA:
undetectable		 2g70B-2mprA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 TYR A 378
GLY A 441
THR A 420
TYR A 418
 None
 1.09A 2g70B-2nlzA:
undetectable		 2g70B-2nlzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A 275
THR A 189
TYR A 273
ASP A 191
 None
 1.09A 2g70B-2pxjA:
undetectable		 2g70B-2pxjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME C1

(Rhodobacter
sphaeroides) 		PF02167
(Cytochrom_C1) 		4 TYR B 132
GLY B 137
THR B 136
ASN B 157
 None
 1.06A 2g70B-2qjpB:
undetectable		 2g70B-2qjpB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 TYR A 615
THR A 613
TYR A 609
ASN A 691
 None
 0.89A 2g70B-2qr7A:
undetectable		 2g70B-2qr7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 4 TYR A 159
TYR A 104
GLY A 157
THR A 131
 None
 0.96A 2g70B-2wjfA:
undetectable		 2g70B-2wjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8p CHOLINE-BINDING
PROTEIN F

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		4 GLY A 270
THR A 253
ASP A 271
ASN A 266
 None
 1.03A 2g70B-2x8pA:
undetectable		 2g70B-2x8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 GLY A 455
THR A 454
ASP A 456
ASN A 448
 None
 1.03A 2g70B-2xhyA:
undetectable		 2g70B-2xhyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 274
THR A 202
TYR A 200
ASP A 273
 None
 0.84A 2g70B-3b96A:
undetectable		 2g70B-3b96A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 152
GLY A 182
THR A 200
ASN A 202
 None
 1.03A 2g70B-3be8A:
undetectable		 2g70B-3be8A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  48
GLY B  96
TYR B  46
ASP B  97
 None
 0.93A 2g70B-3c60B:
undetectable		 2g70B-3c60B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 ALPHA
CHAIN
TCR YAE62 BETA CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  48
GLY A  94
THR A  97
TYR B  46
 None
 0.99A 2g70B-3c60B:
undetectable		 2g70B-3c60B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 TYR A 229
GLY A 187
THR A 186
ASP A 188
 None
 1.07A 2g70B-3c87A:
undetectable		 2g70B-3c87A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B

(Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 TYR A 260
GLY A 381
TYR A 369
ASN A 320
 None
ADP  A 500 (-3.7A)
None
None
 1.02A 2g70B-3d36A:
undetectable		 2g70B-3d36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLY A 362
THR A 143
ASP A 361
ASN A 363
 None
None
CA  A   1 (-3.0A)
CA  A   1 (-3.0A)
 1.04A 2g70B-3evrA:
undetectable		 2g70B-3evrA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 TYR A  14
GLY A  46
THR A  49
TYR A  21
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.4A)
SAH  A 308 (-4.6A)
SAH  A 308 (-2.6A)
 0.95A 2g70B-3g5tA:
12.5		 2g70B-3g5tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtn ADAPTER PROTEIN MECA
2

(Bacillus
subtilis) 		PF05389
(MecA) 		4 TYR A  31
GLY A  80
THR A  29
ASN A  81
 None
 0.73A 2g70B-3jtnA:
undetectable		 2g70B-3jtnA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 TYR A 427
GLY A 420
THR A 417
TYR A 413
 None
 1.03A 2g70B-3m8uA:
undetectable		 2g70B-3m8uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		4 TYR A 187
GLY A  75
THR A  76
TYR A 195
 None
 0.95A 2g70B-3oamA:
undetectable		 2g70B-3oamA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 GLY A  39
THR A  38
TYR A  47
ASP A  40
 None
 1.07A 2g70B-3p1vA:
undetectable		 2g70B-3p1vA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 TYR A  47
GLY A  39
THR A  38
ASP A  40
 None
 0.94A 2g70B-3p1vA:
undetectable		 2g70B-3p1vA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A 198
THR A 197
ASP A 199
ASN A 178
 CA  A 409 (-4.2A)
None
None
None
 1.07A 2g70B-3p4gA:
undetectable		 2g70B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A 257
THR A 256
ASP A 258
ASN A 237
 CA  A 412 (-4.3A)
None
None
None
 1.00A 2g70B-3p4gA:
undetectable		 2g70B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		4 TYR A 566
GLY A 528
THR A 327
ASN A 525
 None
None
None
EOH  A   1 (-3.6A)
 0.99A 2g70B-3pamA:
undetectable		 2g70B-3pamA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TYR H 100
TYR H 100
GLY H  97
ASP H  95
 None
 1.08A 2g70B-3piqH:
undetectable		 2g70B-3piqH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 TYR A 215
GLY A 178
THR A 179
TYR A 182
 None
 1.06A 2g70B-3ujgA:
undetectable		 2g70B-3ujgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		4 TYR A 281
GLY A 117
THR A 279
ASN A 118
 None
None
None
ZN  A 325 ( 4.7A)
 0.98A 2g70B-3un6A:
undetectable		 2g70B-3un6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 TYR A 233
GLY A 225
THR A 229
TYR A 230
 None
None
None
ANP  A1401 ( 4.7A)
 1.00A 2g70B-3zlbA:
2.7		 2g70B-3zlbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 GLY A  14
TYR A  85
ASP A  13
ASN A  72
 None
 1.09A 2g70B-4aovA:
undetectable		 2g70B-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg0 COMPLEMENT
REGULATOR-ACQUIRING
SURFACE PROTEIN 2
(CRASP-2 (CRASP-2)

(Borreliella
burgdorferi) 		no annotation 4 GLY A  38
THR A  37
TYR A  33
ASP A  42
 None
 1.04A 2g70B-4bg0A:
undetectable		 2g70B-4bg0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 TYR A 339
TYR A 338
GLY A  38
THR A 342
 None
 0.99A 2g70B-4c1oA:
undetectable		 2g70B-4c1oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		4 GLY A 488
THR A 487
TYR A 436
ASN A 255
 None
 1.08A 2g70B-4egtA:
undetectable		 2g70B-4egtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 TYR A  74
GLY A  98
THR A  97
ASP A 123
 None
 1.08A 2g70B-4eqyA:
undetectable		 2g70B-4eqyA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 TYR A 107
GLY A 102
THR C  16
ASP C 217
ASN A 103
 None
 1.40A 2g70B-4gh4A:
undetectable		 2g70B-4gh4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 TYR A 156
GLY A  68
THR A  69
ASN A 101
 KPI  A 184 ( 3.8A)
KPI  A 184 ( 3.5A)
KPI  A 184 ( 4.3A)
None
 1.07A 2g70B-4hnnA:
undetectable		 2g70B-4hnnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3r UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF16139
(DUF4847) 		4 THR A 155
TYR A 157
ASP A 150
ASN A 153
 None
 0.95A 2g70B-4l3rA:
undetectable		 2g70B-4l3rA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		4 TYR A 432
GLY A 330
THR A 329
ASP A 345
 None
 0.90A 2g70B-4l8nA:
undetectable		 2g70B-4l8nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 TYR H  94
GLY H  26
THR H  25
TYR H 102
ASP H  27
 None
 1.48A 2g70B-4laqH:
undetectable		 2g70B-4laqH:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 GLY A 603
THR A 604
ASP A 601
ASN A 602
 CA  A 802 ( 4.4A)
None
CA  A 802 (-2.2A)
CA  A 802 (-3.0A)
 0.98A 2g70B-4m00A:
undetectable		 2g70B-4m00A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m02 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 GLY A 603
THR A 604
ASP A 601
ASN A 602
 CA  A 701 ( 4.5A)
None
CA  A 701 (-2.2A)
CA  A 701 (-3.0A)
 1.07A 2g70B-4m02A:
undetectable		 2g70B-4m02A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 TYR A 213
TYR A 204
GLY A 241
THR A 239
 None
 1.03A 2g70B-4my0A:
undetectable		 2g70B-4my0A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 TYR A 491
GLY A 442
THR A 489
ASP A 448
 None
 0.96A 2g70B-4pe2A:
undetectable		 2g70B-4pe2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		4 TYR A  62
GLY A  48
THR A  51
ASN A 260
 None
 0.94A 2g70B-4q7qA:
undetectable		 2g70B-4q7qA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 TYR A 317
TYR A 316
GLY A  15
THR A 320
 None
 1.02A 2g70B-4rhhA:
undetectable		 2g70B-4rhhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 TYR B 211
GLY B 200
THR B 213
TYR B 215
ASN B 270
 None
 1.35A 2g70B-4tqoB:
undetectable		 2g70B-4tqoB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 TYR A 429
GLY A 361
THR A 413
ASN A 303
 None
 0.68A 2g70B-4xprA:
undetectable		 2g70B-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 432
TYR A 142
ASP A 430
ASN A 133
 None
 0.86A 2g70B-4z2aA:
undetectable		 2g70B-4z2aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53
LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  99
TYR L  32
GLY H  99
ASP H  99
 None
 1.02A 2g70B-4ztpH:
undetectable		 2g70B-4ztpH:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 TYR C 259
GLY C 263
THR C 547
ASN C 444
 None
 1.08A 2g70B-5aa5C:
undetectable		 2g70B-5aa5C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeb LRA-12

(uncultured
bacterium BLR12) 		PF00753
(Lactamase_B) 		4 TYR A 236
GLY A 199
TYR A 154
ASP A 139
 None
 1.08A 2g70B-5aebA:
undetectable		 2g70B-5aebA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca6 PORCINE ROTAVIRUS
TFR-41 VP8*

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 TYR A 189
GLY A 187
THR A 176
TYR A 165
 PLM  A 307 (-3.2A)
None
None
None
 0.77A 2g70B-5ca6A:
undetectable		 2g70B-5ca6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy0 TS3 TOXIN

(Tityus
serrulatus) 		PF00537
(Toxin_3) 		4 TYR A  48
TYR A  37
GLY A   4
TYR A  39
 None
 0.98A 2g70B-5cy0A:
undetectable		 2g70B-5cy0A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		4 GLY A 558
THR A 559
TYR A 532
ASN A 556
 None
 1.03A 2g70B-5emiA:
undetectable		 2g70B-5emiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7l NANOBODY NB-ER14

(Lama glama) 		PF07686
(V-set) 		4 TYR B  98
GLY B  35
THR B  50
TYR B  58
 None
 0.88A 2g70B-5f7lB:
undetectable		 2g70B-5f7lB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		4 TYR A  84
GLY A  68
THR A  70
TYR A  77
 None
 0.95A 2g70B-5f8eA:
13.4		 2g70B-5f8eA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		4 TYR A 255
GLY A 321
THR A 323
TYR A 295
 None
 0.89A 2g70B-5g5nA:
undetectable		 2g70B-5g5nA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 772
THR A 650
ASP A 773
ASN A 587
 None
 1.02A 2g70B-5ju6A:
undetectable		 2g70B-5ju6A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 GLY A 223
THR A 222
ASP A 224
ASN A   4
 None
 0.89A 2g70B-5lv9A:
1.8		 2g70B-5lv9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 TYR B 289
GLY B 137
THR B 138
TYR B 141
 CU  B 701 (-4.7A)
None
None
None
 0.99A 2g70B-5lxzB:
undetectable		 2g70B-5lxzB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLY A  37
THR A  36
ASP A  38
ASN A  58
 None
 0.84A 2g70B-5ngkA:
undetectable		 2g70B-5ngkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 TYR B 625
GLY B 622
THR B 540
ASP B 681
 None
 0.90A 2g70B-5of4B:
undetectable		 2g70B-5of4B:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		4 TYR A  77
THR A 271
TYR A 128
ASN A 279
 None
 0.95A 2g70B-5sv9A:
undetectable		 2g70B-5sv9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1

(Entamoeba
histolytica) 		no annotation 4 TYR C  82
TYR C  64
GLY C  31
TYR C  48
 None
 1.09A 2g70B-5swkC:
undetectable		 2g70B-5swkC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 4 GLY A 194
THR A 198
TYR A 205
ASP A 193
 None
 1.06A 2g70B-5v2mA:
undetectable		 2g70B-5v2mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 4 TYR A  80
TYR A 194
GLY A  51
THR A  20
 None
 0.83A 2g70B-5vqjA:
undetectable		 2g70B-5vqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 TYR A 214
GLY A 203
THR A 216
TYR A 218
ASN A 273
 None
 1.38A 2g70B-5xm3A:
undetectable		 2g70B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L3

(Mycolicibacterium
smegmatis) 		PF00297
(Ribosomal_L3) 		4 GLY D 203
THR D   9
TYR D  54
ASN D 202
 None
 0.97A 2g70B-5xymD:
undetectable		 2g70B-5xymD:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 4 TYR A 278
TYR A  99
GLY A  75
TYR A  86
 None
 0.78A 2g70B-6d3uA:
undetectable		 2g70B-6d3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLY A 348
THR A 347
ASP A 352
ASN A 339
 None
 0.88A 2g70B-6enoA:
undetectable		 2g70B-6enoA:
undetectable