SIMILAR PATTERNS OF AMINO ACIDS FOR 2G70_B_SAMB2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 TYR A 265
LEU A 269
HIS A 289
ALA A 249
VAL A 257
 None
None
G  B  34 ( 4.4A)
None
None
 1.42A 2g70B-1h3eA:
undetectable		 2g70B-1h3eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE
RAD50 ABC-ATPASE

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF13476
(AAA_23)
PF13304
(AAA_21) 		5 GLN A 142
LEU A 163
VAL B 769
ALA A 145
VAL B 776
 None
 1.40A 2g70B-1ii8A:
undetectable		 2g70B-1ii8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A 118
ASP A  11
HIS A   8
ALA A  25
VAL A   6
 None
 1.06A 2g70B-1iqrA:
2.3		 2g70B-1iqrA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		12 TYR A  27
GLN A  86
PHE A 102
LEU A 103
ASP A 158
VAL A 159
HIS A 160
ALA A 181
PHE A 182
CYH A 183
VAL A 187
TYR A 222
 SAH  A2002 (-3.6A)
SAH  A2002 ( 4.2A)
SAH  A2002 (-4.4A)
SAH  A2002 (-3.9A)
SAH  A2002 (-3.6A)
SAH  A2002 (-3.5A)
SAH  A2002 (-4.1A)
SAH  A2002 (-3.3A)
IDI  A3003 ( 3.4A)
SAH  A2002 (-3.4A)
SAH  A2002 (-4.3A)
IDI  A3003 (-3.8A)
 0.50A 2g70B-1n7jA:
46.5		 2g70B-1n7jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 411
VAL A 345
HIS A 606
PHE A 618
VAL A 610
 None
 1.40A 2g70B-1qjmA:
undetectable		 2g70B-1qjmA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 112
ASP A 107
HIS A 105
ALA A  26
PHE A  27
 None
 1.45A 2g70B-1tf0A:
undetectable		 2g70B-1tf0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 VAL A  57
ALA A 473
PHE A 477
CYH A 475
VAL A 481
 None
 1.15A 2g70B-1tmoA:
undetectable		 2g70B-1tmoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 363
ASP A 237
VAL A 177
ALA A 249
VAL A 350
 LEU  A 363 ( 0.6A)
ASP  A 237 ( 0.5A)
VAL  A 177 ( 0.6A)
ALA  A 249 ( 0.0A)
VAL  A 350 ( 0.6A)
 1.20A 2g70B-1wqaA:
undetectable		 2g70B-1wqaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		5 LEU A 132
ASP A  21
ALA A  76
PHE A  61
CYH A  74
 None
 1.35A 2g70B-1yleA:
undetectable		 2g70B-1yleA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		5 TYR A 117
PHE A 112
VAL A 110
ALA A 140
VAL A 115
 None
 1.45A 2g70B-1zjrA:
undetectable		 2g70B-1zjrA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  11
GLN A  70
PHE A  86
ASP A 142
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.52A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A  60
ASP A  27
VAL A  30
VAL A  65
TYR A 102
 None
 1.39A 2g70B-2bkgA:
undetectable		 2g70B-2bkgA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  12
GLN A  71
ASP A 143
VAL A 144
CYH A 166
TYR A 205
 SAH  A4001 (-3.8A)
SAH  A4001 ( 4.3A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.6A)
SAH  A4001 ( 3.8A)
None
 0.37A 2g70B-2i62A:
37.0		 2g70B-2i62A:
37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  11
GLN A  70
ASP A 142
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-4.1A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.46A 2g70B-2iipA:
36.6		 2g70B-2iipA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mkk CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF16367
(RRM_7) 		5 LEU A 361
VAL A 396
ALA A 410
PHE A 412
VAL A 354
 None
 1.35A 2g70B-2mkkA:
undetectable		 2g70B-2mkkA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU C 142
ASP C  84
VAL C  83
PHE C 154
CYH C 152
 None
 1.30A 2g70B-2nn6C:
undetectable		 2g70B-2nn6C:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 LEU A  18
VAL A 246
ALA A 285
CYH A 295
VAL A 312
 None
 1.32A 2g70B-2nqnA:
undetectable		 2g70B-2nqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 LEU A 161
ASP A 139
ALA A 261
PHE A  52
VAL A   6
 None
 1.42A 2g70B-2nwhA:
4.0		 2g70B-2nwhA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		5 HIS B  62
ALA B 112
CYH B 111
VAL B  87
TYR B 132
 None
 1.42A 2g70B-2pbiB:
undetectable		 2g70B-2pbiB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PHE X 159
LEU X 156
ASP X 229
HIS X 170
CYH X 100
 None
 1.26A 2g70B-2pmoX:
undetectable		 2g70B-2pmoX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12

(Homo sapiens) 		PF00644
(PARP) 		5 TYR A 670
VAL A 674
ALA A 573
CYH A 575
VAL A 532
 None
None
CIT  A 801 ( 4.4A)
None
None
 1.17A 2g70B-2pqfA:
undetectable		 2g70B-2pqfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		5 TYR B 181
GLN B  91
LEU B 172
VAL B 164
ALA B  92
 None
 1.46A 2g70B-2qb0B:
undetectable		 2g70B-2qb0B:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 TYR A 390
VAL A 143
ALA A 315
PHE A 286
TYR A 285
 None
 1.26A 2g70B-3anyA:
undetectable		 2g70B-3anyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 396
VAL A 334
HIS A 392
ALA A 307
PHE A 274
 None
 1.39A 2g70B-3au9A:
undetectable		 2g70B-3au9A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		5 PHE A  47
LEU A  93
ASP A  65
VAL A  66
VAL A  41
 None
 1.13A 2g70B-3bwhA:
undetectable		 2g70B-3bwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A  92
LEU A 114
ASP A 144
VAL A 143
ALA A 133
 None
None
MG  A 701 (-2.9A)
None
None
 1.44A 2g70B-3cmvA:
undetectable		 2g70B-3cmvA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A  40
VAL A 251
HIS A 250
ALA A   9
PHE A  79
 None
 1.44A 2g70B-3d5tA:
5.1		 2g70B-3d5tA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 187
VAL A 227
HIS A 265
ALA A 166
VAL A 269
 None
None
None
HEM  A 500 ( 4.4A)
None
 1.40A 2g70B-3dbgA:
undetectable		 2g70B-3dbgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 LEU A 180
ASP A 125
VAL A  33
HIS A  29
ALA A 115
 None
 1.13A 2g70B-3dtoA:
undetectable		 2g70B-3dtoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejf NON-STRUCTURAL
PROTEIN 3

(Avian
coronavirus) 		PF01661
(Macro) 		5 ASP A 117
VAL A 116
CYH A  89
VAL A  79
TYR A  64
 None
 0.94A 2g70B-3ejfA:
undetectable		 2g70B-3ejfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		5 GLN A 235
ASP A  37
VAL A  36
HIS A   0
ALA A 240
 None
 1.35A 2g70B-3ez4A:
undetectable		 2g70B-3ez4A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLN A 288
ASP A 145
VAL A 144
HIS A 143
ALA A 287
 None
 1.29A 2g70B-3gb4A:
undetectable		 2g70B-3gb4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		5 LEU B 172
ASP B 144
ALA B  33
VAL B 184
TYR B  54
 None
 1.19A 2g70B-3gzyB:
undetectable		 2g70B-3gzyB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9j MCCB PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		5 LEU A 319
VAL A 210
ALA A 298
CYH A 302
VAL A 306
 None
 1.41A 2g70B-3h9jA:
4.0		 2g70B-3h9jA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 213
VAL A 173
ALA A 222
CYH A 221
VAL A 162
 None
 1.33A 2g70B-3k30A:
undetectable		 2g70B-3k30A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqw CG11900

(Drosophila
melanogaster) 		PF13328
(HD_4) 		5 LEU A 169
ASP A 126
VAL A  40
HIS A  36
ALA A 116
 None
None
None
MN  A 300 (-3.5A)
None
 1.43A 2g70B-3nqwA:
undetectable		 2g70B-3nqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		5 ASP A  49
ALA A  37
CYH A  89
VAL A  78
TYR A  59
 None
 1.44A 2g70B-3odgA:
undetectable		 2g70B-3odgA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		5 ASP A 186
VAL A 182
ALA A 233
CYH A 266
VAL A 216
 None
 1.45A 2g70B-3q5eA:
undetectable		 2g70B-3q5eA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 PHE A 341
LEU A 335
ASP A 294
VAL A 295
ALA A 286
 None
 1.30A 2g70B-3qfhA:
undetectable		 2g70B-3qfhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A 249
LEU A  23
VAL A   8
ALA A 244
VAL A  80
 None
 1.38A 2g70B-3tl2A:
4.0		 2g70B-3tl2A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmc UNCHARACTERIZED
PROTEIN

(Bdellovibrio
bacteriovorus) 		PF13487
(HD_5) 		5 LEU A 285
ASP A 268
VAL A 154
HIS A 150
ALA A 258
 None
DMS  A 312 (-4.0A)
None
FE  A 310 ( 3.3A)
None
 1.31A 2g70B-3tmcA:
undetectable		 2g70B-3tmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 LEU A 193
VAL A 110
ALA A  52
CYH A  27
VAL A  18
 None
 1.37A 2g70B-3tp9A:
undetectable		 2g70B-3tp9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 PHE A  93
LEU A 296
ASP A  92
VAL A  91
PHE A  66
 None
 1.44A 2g70B-3tpfA:
4.3		 2g70B-3tpfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ASP A 416
VAL A 417
HIS A 414
ALA A 394
VAL A 432
 None
 1.45A 2g70B-3ulzA:
undetectable		 2g70B-3ulzA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		5 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.29A 2g70B-3wsuA:
undetectable		 2g70B-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 PHE B 328
LEU B 329
ASP B 258
ALA B 318
VAL B 261
 None
 1.11A 2g70B-3x17B:
undetectable		 2g70B-3x17B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		5 GLN A 387
ASP A 431
VAL A 397
HIS A 399
TYR A 264
 None
 1.45A 2g70B-4b61A:
undetectable		 2g70B-4b61A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 GLN A  30
PHE A 144
LEU A  78
VAL A  26
VAL A 167
 None
 1.41A 2g70B-4bbwA:
undetectable		 2g70B-4bbwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY

(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF17524
(CnrY) 		5 VAL B  14
HIS B  10
ALA A  36
PHE A  40
VAL A 131
 None
 1.45A 2g70B-4cxfB:
undetectable		 2g70B-4cxfB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 LEU A 296
HIS A 251
ALA A 343
PHE A 368
VAL A 284
 None
 1.28A 2g70B-4e4gA:
undetectable		 2g70B-4e4gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 227
ASP A 253
VAL A 254
ALA A 508
PHE A 507
 None
 1.40A 2g70B-4fsfA:
undetectable		 2g70B-4fsfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkf CRISPR SYSTEM CMR
SUBUNIT CMR5

(Pyrococcus
furiosus) 		PF09701
(Cas_Cmr5) 		5 TYR A  45
LEU A  48
ALA A 156
PHE A 153
VAL A  33
 None
 1.43A 2g70B-4gkfA:
undetectable		 2g70B-4gkfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 GLN A 138
ASP A   8
VAL A   7
ALA A 136
VAL A 159
 None
 1.20A 2g70B-4hfoA:
undetectable		 2g70B-4hfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl6 UNCHARACTERIZED
PROTEIN YFDE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 GLN A 148
ASP A  49
VAL A  21
HIS A  20
ALA A 172
 None
 1.34A 2g70B-4hl6A:
undetectable		 2g70B-4hl6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic5 PROTEASE DO-LIKE 5,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13365
(Trypsin_2) 		5 LEU A 271
VAL A 305
ALA A 254
PHE A 298
VAL A 280
 None
 1.46A 2g70B-4ic5A:
undetectable		 2g70B-4ic5A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU S 109
VAL S 145
ALA S 119
PHE S  73
VAL S  76
 None
 1.19A 2g70B-4ko2S:
undetectable		 2g70B-4ko2S:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		5 GLN A 119
PHE A 326
LEU A 239
ALA A 158
VAL A   6
 None
 1.39A 2g70B-4mnmA:
undetectable		 2g70B-4mnmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 GLN A 960
ASP A 909
VAL A 905
ALA A 951
CYH A 928
 None
 1.36A 2g70B-4n3nA:
undetectable		 2g70B-4n3nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLN A4302
ASP A4261
ALA A4305
PHE A4293
VAL A4290
 None
 1.45A 2g70B-4opeA:
undetectable		 2g70B-4opeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae;
Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB)
PF03116
(NQR2_RnfD_RnfE)
PF02508
(Rnf-Nqr) 		5 TYR E 166
ASP B 397
VAL B 401
HIS B 398
ALA A 410
 None
None
None
RBF  E 201 ( 4.9A)
None
 1.29A 2g70B-4p6vE:
undetectable		 2g70B-4p6vE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Aspergillus
fumigatus) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 438
HIS A 265
ALA A 421
PHE A 373
TYR A 374
 None
2XQ  A 505 (-4.0A)
None
None
None
 1.41A 2g70B-4qbjA:
undetectable		 2g70B-4qbjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		5 PHE A 215
VAL A 220
ALA A 285
PHE A 211
TYR A 244
 None
 1.36A 2g70B-4qx8A:
undetectable		 2g70B-4qx8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  49
VAL A 277
HIS A 424
ALA A 207
VAL A 274
 None
 1.25A 2g70B-4r1dA:
undetectable		 2g70B-4r1dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		5 GLN A 510
PHE A 295
LEU A 514
ALA A 509
PHE A 268
 None
 1.39A 2g70B-4uooA:
undetectable		 2g70B-4uooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 149
ASP A 156
VAL A 155
PHE A 185
VAL A 191
 None
 1.32A 2g70B-4wwhA:
undetectable		 2g70B-4wwhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 337
VAL A 282
ALA A 344
VAL A 280
TYR A 368
 None
 1.41A 2g70B-4wz9A:
undetectable		 2g70B-4wz9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 TYR A  71
GLN A  22
LEU A  63
VAL A  85
VAL A 126
 None
 1.28A 2g70B-4yacA:
7.0		 2g70B-4yacA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk3 BEPE PROTEIN

(Bartonella
henselae) 		no annotation 5 GLN A 244
LEU A 235
ASP A 193
ALA A 245
VAL A 184
 None
 1.30A 2g70B-4yk3A:
undetectable		 2g70B-4yk3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		5 GLN A 289
LEU A 306
ALA A  99
CYH A 101
VAL A 112
 None
 1.22A 2g70B-4ypvA:
undetectable		 2g70B-4ypvA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A2415
LEU A2475
ALA A2391
PHE A2390
VAL A2563
 None
 0.98A 2g70B-4z37A:
undetectable		 2g70B-4z37A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 647
LEU A 706
ALA A 623
PHE A 622
VAL A 794
 None
 0.95A 2g70B-4zdnA:
undetectable		 2g70B-4zdnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		5 VAL A 361
PHE A 397
CYH A 395
VAL A 391
TYR A 419
 None
 1.45A 2g70B-5c6gA:
undetectable		 2g70B-5c6gA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuz METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
D PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF10229
(MMADHC) 		5 TYR A 249
LEU A 252
ALA A 208
PHE A 224
VAL A 276
 None
 1.44A 2g70B-5cuzA:
undetectable		 2g70B-5cuzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 PHE A 266
ASP A 209
VAL A 210
ALA A 288
CYH A 286
 None
SAH  A 401 ( 4.6A)
None
None
None
 1.34A 2g70B-5cvvA:
12.5		 2g70B-5cvvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 GLN A 290
LEU A 301
ASP A 594
ALA A 324
VAL A 567
 None
 1.45A 2g70B-5cxwA:
undetectable		 2g70B-5cxwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 LEU A 200
VAL A 112
ALA A  78
VAL A  72
TYR A 144
 None
 1.44A 2g70B-5eoeA:
undetectable		 2g70B-5eoeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		5 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.20A 2g70B-5g4lA:
6.1		 2g70B-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 TYR A 733
GLN A  16
LEU A 782
PHE A1213
VAL A 742
 None
 1.40A 2g70B-5hy7A:
undetectable		 2g70B-5hy7A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 275
ASP A 605
ALA A  66
PHE A  68
CYH A  86
 None
None
None
None
FAD  A 702 ( 4.1A)
 1.45A 2g70B-5i68A:
undetectable		 2g70B-5i68A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 PHE A 444
VAL A 366
ALA B1107
PHE A 347
VAL A 442
 None
 1.45A 2g70B-5ip9A:
undetectable		 2g70B-5ip9A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgj UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF01209
(Ubie_methyltran) 		5 LEU A  29
ASP A  36
VAL A  35
ALA A  59
VAL A  63
 None
 1.43A 2g70B-5jgjA:
9.5		 2g70B-5jgjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwr CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 PHE A 195
VAL A 151
ALA A 169
PHE A 166
VAL A 161
 None
 1.32A 2g70B-5jwrA:
2.8		 2g70B-5jwrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		5 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.35A 2g70B-5lgdA:
undetectable		 2g70B-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 TYR B 295
LEU B 345
PHE C   7
VAL B 293
TYR C   3
 None
 1.37A 2g70B-5n28B:
undetectable		 2g70B-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2k BRIAKINUMAB FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 TYR G  87
LEU G  48
VAL G  18
ALA G  81
VAL G 108
 None
 1.42A 2g70B-5n2kG:
undetectable		 2g70B-5n2kG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 PHE A 492
LEU A 413
ASP A 483
ALA A 384
PHE A 380
 None
 1.10A 2g70B-5nv6A:
undetectable		 2g70B-5nv6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		5 LEU A 209
ASP A 202
ALA A 262
PHE A 164
VAL A 255
 None
 1.41A 2g70B-5o5oA:
undetectable		 2g70B-5o5oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5s RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		5 LEU A 209
ASP A 202
ALA A 262
PHE A 164
VAL A 255
 None
 1.37A 2g70B-5o5sA:
undetectable		 2g70B-5o5sA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 GLN A 191
ASP A 295
VAL A 296
ALA A 396
PHE A 397
 None
 1.32A 2g70B-5svcA:
undetectable		 2g70B-5svcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		5 LEU A 297
HIS A 252
ALA A 344
PHE A 369
VAL A 285
 None
 1.35A 2g70B-5tjrA:
undetectable		 2g70B-5tjrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		5 PHE 8 318
LEU 8 363
VAL 8 404
ALA 8 310
PHE 8 313
 None
 1.31A 2g70B-5udb8:
undetectable		 2g70B-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woq TRANSCRIPTIONAL
REGULATOR CLGR

(Mycolicibacterium
smegmatis) 		PF13560
(HTH_31) 		5 ASP A  70
VAL A  67
ALA A  55
CYH A  57
VAL A  62
 None
 1.14A 2g70B-5woqA:
undetectable		 2g70B-5woqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii;
Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 PHE A 445
VAL A 367
ALA B1107
PHE A 348
VAL A 443
 None
 1.46A 2g70B-5xogA:
undetectable		 2g70B-5xogA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0m -

(-) 		no annotation 5 GLN A 176
LEU A 106
VAL A  58
ALA A 203
VAL A 273
 None
 1.41A 2g70B-5y0mA:
undetectable		 2g70B-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.29A 2g70B-5zb3A:
undetectable		 2g70B-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 5 GLN A 381
PHE A  83
LEU A  27
VAL A  80
ALA A 106
 None
 1.24A 2g70B-6c93A:
undetectable		 2g70B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 5 PHE A 350
LEU A 464
ASP A 354
ALA A 454
VAL A 149
 None
None
None
HEM  A 600 (-3.4A)
None
 1.38A 2g70B-6c93A:
undetectable		 2g70B-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn7 AEROBACTIN SYNTHASE
IUCC

(Klebsiella
pneumoniae) 		no annotation 5 GLN A 436
PHE A 401
LEU A 397
HIS A 484
ALA A 429
 None
 1.25A 2g70B-6cn7A:
undetectable		 2g70B-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.18A 2g70B-6fa5A:
undetectable		 2g70B-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 5 GLN A 634
PHE A 529
VAL A 531
HIS A 532
ALA A 633
 None
None
None
CLA  A1135 (-4.3A)
None
 1.16A 2g70B-6fosA:
undetectable		 2g70B-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7j PROTEIN
(PARA-NITROBENZYL
ESTERASE)

(Bacillus
subtilis) 		PF00135
(COesterase) 		4 TYR A  57
GLY A 113
THR A 133
ASN A 135
 None
 0.89A 2g70B-1c7jA:
undetectable		 2g70B-1c7jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		4 TYR A  71
GLY A 138
THR A  48
ASN A 142
 None
 1.06A 2g70B-1cp9A:
undetectable		 2g70B-1cp9A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 TYR A 191
GLY A 317
THR A 292
ASP A 318
 None
 1.07A 2g70B-1csjA:
undetectable		 2g70B-1csjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 TYR A 284
GLY A 315
THR A 313
ASP A  56
 None
None
None
CA  A 803 (-2.5A)
 1.05A 2g70B-1cvmA:
undetectable		 2g70B-1cvmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 TYR A 462
GLY A 457
THR A 455
TYR A 438
 None
 0.97A 2g70B-1fokA:
undetectable		 2g70B-1fokA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 TYR A 108
GLY A  92
THR A  81
ASP A  91
 None
 1.07A 2g70B-1gw1A:
undetectable		 2g70B-1gw1A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 TYR A  82
GLY A 163
THR A 113
ASP A 166
 None
 1.06A 2g70B-1hjuA:
undetectable		 2g70B-1hjuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu4 MICROBIAL
TRANSGLUTAMINASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		4 TYR A 256
TYR A 198
GLY A  66
THR A  68
 None
 1.08A 2g70B-1iu4A:
undetectable		 2g70B-1iu4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 TYR A 183
GLY A 172
THR A 185
TYR A 187
ASN A 242
 None
 1.35A 2g70B-1lrwA:
undetectable		 2g70B-1lrwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 TYR A  86
GLY A  89
ASP A  90
ASN A 364
 None
 0.93A 2g70B-1m2wA:
3.1		 2g70B-1m2wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		5 GLY A 267
THR A 236
TYR A 234
ASP A 298
ASN A 266
 None
 1.42A 2g70B-1mpoA:
undetectable		 2g70B-1mpoA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  35
TYR A  40
GLY A  81
THR A  83
TYR A  85
ASP A 101
ASN A 106
 SAH  A2002 ( 4.4A)
SAH  A2002 (-4.6A)
SAH  A2002 (-3.0A)
SAH  A2002 (-2.9A)
SAH  A2002 (-4.6A)
SAH  A2002 (-3.1A)
SAH  A2002 (-3.6A)
 0.21A 2g70B-1n7jA:
46.5		 2g70B-1n7jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8r GUANYLIN

(Homo sapiens) 		PF02058
(Guanylin) 		4 GLY A  81
THR A  82
TYR A  88
ASP A  79
 None
 1.00A 2g70B-1o8rA:
undetectable		 2g70B-1o8rA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 TYR A  58
GLY A  23
ASP A  24
ASN A  25
 None
 1.08A 2g70B-1qs8A:
undetectable		 2g70B-1qs8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 TYR A 224
GLY A 140
TYR A 210
ASP A  60
 None
 0.94A 2g70B-1ru3A:
2.6		 2g70B-1ru3A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLY A 377
THR A 389
TYR A 421
ASN A 376
 None
 0.98A 2g70B-1ryyA:
undetectable		 2g70B-1ryyA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		4 TYR A  91
GLY A  97
TYR A 145
ASP A 112
 None
None
None
CA  A2184 (-2.5A)
 1.02A 2g70B-1sddA:
undetectable		 2g70B-1sddA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 TYR A  59
GLY A  78
THR A  77
ASP A  79
 None
 0.78A 2g70B-1sivA:
undetectable		 2g70B-1sivA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp3 CYTOCHROME C,
PUTATIVE

(Shewanella
oneidensis) 		PF11783
(Cytochrome_cB)
PF13435
(Cytochrome_C554) 		4 TYR A 314
GLY A 317
ASP A 321
ASN A 292
 None
 1.08A 2g70B-1sp3A:
undetectable		 2g70B-1sp3A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vic 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Haemophilus
influenzae) 		PF02348
(CTP_transf_3) 		4 TYR A 191
GLY A  75
THR A  76
TYR A 199
 None
 0.92A 2g70B-1vicA:
undetectable		 2g70B-1vicA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.08A 2g70B-1w6sA:
undetectable		 2g70B-1w6sA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 GLY A 431
THR A 433
TYR A 435
ASN A 310
 None
 0.71A 2g70B-1wkyA:
undetectable		 2g70B-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii;
Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A)
PF02310
(B12-binding)
PF16554
(OAM_dimer) 		4 TYR B 146
GLY A 204
THR A 185
TYR A 207
 B12  B 800 (-4.2A)
None
None
None
 0.96A 2g70B-1xrsB:
undetectable		 2g70B-1xrsB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztm FUSION GLYCOPROTEIN

(Human
respirovirus 3) 		PF00523
(Fusion_gly) 		4 GLY A 215
THR A 211
TYR A 207
ASP A 216
 None
 1.07A 2g70B-1ztmA:
undetectable		 2g70B-1ztmA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 TYR A  20
THR A  67
TYR A  25
ASP A  61
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
None
 0.87A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
 0.32A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 277
THR A 114
TYR A 112
ASP A 279
 None
None
FAD  A 480 (-3.4A)
None
 1.05A 2g70B-2a8xA:
2.3		 2g70B-2a8xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 TYR A 563
GLY A 576
TYR A 249
ASN A 578
 None
 1.06A 2g70B-2d5wA:
undetectable		 2g70B-2d5wA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  21
TYR A  26
GLY A  66
THR A  68
TYR A  70
ASP A  86
ASN A  91
 SAH  A4001 (-4.5A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.2A)
SAH  A4001 (-3.6A)
SAH  A4001 (-4.3A)
SAH  A4001 (-2.9A)
SAH  A4001 (-3.9A)
 0.32A 2g70B-2i62A:
37.0		 2g70B-2i62A:
37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.6A)
SAH  A4001 (-2.6A)
SAH  A4001 (-4.0A)
 0.34A 2g70B-2iipA:
36.6		 2g70B-2iipA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		4 TYR A 237
TYR A 265
GLY A 270
ASP A 271
 None
 0.88A 2g70B-2j7aA:
undetectable		 2g70B-2j7aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica) 		PF02264
(LamB) 		5 GLY A 277
THR A 236
TYR A 234
ASP A 308
ASN A 276
 None
 1.40A 2g70B-2mprA:
undetectable		 2g70B-2mprA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 TYR A 378
GLY A 441
THR A 420
TYR A 418
 None
 1.09A 2g70B-2nlzA:
undetectable		 2g70B-2nlzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A 275
THR A 189
TYR A 273
ASP A 191
 None
 1.09A 2g70B-2pxjA:
undetectable		 2g70B-2pxjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME C1

(Rhodobacter
sphaeroides) 		PF02167
(Cytochrom_C1) 		4 TYR B 132
GLY B 137
THR B 136
ASN B 157
 None
 1.06A 2g70B-2qjpB:
undetectable		 2g70B-2qjpB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 TYR A 615
THR A 613
TYR A 609
ASN A 691
 None
 0.89A 2g70B-2qr7A:
undetectable		 2g70B-2qr7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 4 TYR A 159
TYR A 104
GLY A 157
THR A 131
 None
 0.96A 2g70B-2wjfA:
undetectable		 2g70B-2wjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8p CHOLINE-BINDING
PROTEIN F

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		4 GLY A 270
THR A 253
ASP A 271
ASN A 266
 None
 1.03A 2g70B-2x8pA:
undetectable		 2g70B-2x8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 GLY A 455
THR A 454
ASP A 456
ASN A 448
 None
 1.03A 2g70B-2xhyA:
undetectable		 2g70B-2xhyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 274
THR A 202
TYR A 200
ASP A 273
 None
 0.84A 2g70B-3b96A:
undetectable		 2g70B-3b96A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be8 NEUROLIGIN-4,
X-LINKED

(Homo sapiens) 		PF00135
(COesterase) 		4 TYR A 152
GLY A 182
THR A 200
ASN A 202
 None
 1.03A 2g70B-3be8A:
undetectable		 2g70B-3be8A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  48
GLY B  96
TYR B  46
ASP B  97
 None
 0.93A 2g70B-3c60B:
undetectable		 2g70B-3c60B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 ALPHA
CHAIN
TCR YAE62 BETA CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  48
GLY A  94
THR A  97
TYR B  46
 None
 0.99A 2g70B-3c60B:
undetectable		 2g70B-3c60B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 TYR A 229
GLY A 187
THR A 186
ASP A 188
 None
 1.07A 2g70B-3c87A:
undetectable		 2g70B-3c87A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B

(Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 TYR A 260
GLY A 381
TYR A 369
ASN A 320
 None
ADP  A 500 (-3.7A)
None
None
 1.02A 2g70B-3d36A:
undetectable		 2g70B-3d36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLY A 362
THR A 143
ASP A 361
ASN A 363
 None
None
CA  A   1 (-3.0A)
CA  A   1 (-3.0A)
 1.04A 2g70B-3evrA:
undetectable		 2g70B-3evrA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 TYR A  14
GLY A  46
THR A  49
TYR A  21
ASP A  68
 SAH  A 308 ( 4.6A)
SAH  A 308 (-3.6A)
SAH  A 308 (-3.4A)
SAH  A 308 (-4.6A)
SAH  A 308 (-2.6A)
 0.95A 2g70B-3g5tA:
12.5		 2g70B-3g5tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtn ADAPTER PROTEIN MECA
2

(Bacillus
subtilis) 		PF05389
(MecA) 		4 TYR A  31
GLY A  80
THR A  29
ASN A  81
 None
 0.73A 2g70B-3jtnA:
undetectable		 2g70B-3jtnA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 TYR A 427
GLY A 420
THR A 417
TYR A 413
 None
 1.03A 2g70B-3m8uA:
undetectable		 2g70B-3m8uA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oam 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Vibrio cholerae) 		PF02348
(CTP_transf_3) 		4 TYR A 187
GLY A  75
THR A  76
TYR A 195
 None
 0.95A 2g70B-3oamA:
undetectable		 2g70B-3oamA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 GLY A  39
THR A  38
TYR A  47
ASP A  40
 None
 1.07A 2g70B-3p1vA:
undetectable		 2g70B-3p1vA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 TYR A  47
GLY A  39
THR A  38
ASP A  40
 None
 0.94A 2g70B-3p1vA:
undetectable		 2g70B-3p1vA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A 198
THR A 197
ASP A 199
ASN A 178
 CA  A 409 (-4.2A)
None
None
None
 1.07A 2g70B-3p4gA:
undetectable		 2g70B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A 257
THR A 256
ASP A 258
ASN A 237
 CA  A 412 (-4.3A)
None
None
None
 1.00A 2g70B-3p4gA:
undetectable		 2g70B-3p4gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		4 TYR A 566
GLY A 528
THR A 327
ASN A 525
 None
None
None
EOH  A   1 (-3.6A)
 0.99A 2g70B-3pamA:
undetectable		 2g70B-3pamA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TYR H 100
TYR H 100
GLY H  97
ASP H  95
 None
 1.08A 2g70B-3piqH:
undetectable		 2g70B-3piqH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 TYR A 215
GLY A 178
THR A 179
TYR A 182
 None
 1.06A 2g70B-3ujgA:
undetectable		 2g70B-3ujgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		4 TYR A 281
GLY A 117
THR A 279
ASN A 118
 None
None
None
ZN  A 325 ( 4.7A)
 0.98A 2g70B-3un6A:
undetectable		 2g70B-3un6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		4 TYR A 233
GLY A 225
THR A 229
TYR A 230
 None
None
None
ANP  A1401 ( 4.7A)
 1.00A 2g70B-3zlbA:
2.7		 2g70B-3zlbA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 GLY A  14
TYR A  85
ASP A  13
ASN A  72
 None
 1.09A 2g70B-4aovA:
undetectable		 2g70B-4aovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg0 COMPLEMENT
REGULATOR-ACQUIRING
SURFACE PROTEIN 2
(CRASP-2 (CRASP-2)

(Borreliella
burgdorferi) 		no annotation 4 GLY A  38
THR A  37
TYR A  33
ASP A  42
 None
 1.04A 2g70B-4bg0A:
undetectable		 2g70B-4bg0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 TYR A 339
TYR A 338
GLY A  38
THR A 342
 None
 0.99A 2g70B-4c1oA:
undetectable		 2g70B-4c1oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		4 GLY A 488
THR A 487
TYR A 436
ASN A 255
 None
 1.08A 2g70B-4egtA:
undetectable		 2g70B-4egtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 TYR A  74
GLY A  98
THR A  97
ASP A 123
 None
 1.08A 2g70B-4eqyA:
undetectable		 2g70B-4eqyA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 TYR A 107
GLY A 102
THR C  16
ASP C 217
ASN A 103
 None
 1.40A 2g70B-4gh4A:
undetectable		 2g70B-4gh4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 TYR A 156
GLY A  68
THR A  69
ASN A 101
 KPI  A 184 ( 3.8A)
KPI  A 184 ( 3.5A)
KPI  A 184 ( 4.3A)
None
 1.07A 2g70B-4hnnA:
undetectable		 2g70B-4hnnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3r UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF16139
(DUF4847) 		4 THR A 155
TYR A 157
ASP A 150
ASN A 153
 None
 0.95A 2g70B-4l3rA:
undetectable		 2g70B-4l3rA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		4 TYR A 432
GLY A 330
THR A 329
ASP A 345
 None
 0.90A 2g70B-4l8nA:
undetectable		 2g70B-4l8nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 TYR H  94
GLY H  26
THR H  25
TYR H 102
ASP H  27
 None
 1.48A 2g70B-4laqH:
undetectable		 2g70B-4laqH:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m00 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 GLY A 603
THR A 604
ASP A 601
ASN A 602
 CA  A 802 ( 4.4A)
None
CA  A 802 (-2.2A)
CA  A 802 (-3.0A)
 0.98A 2g70B-4m00A:
undetectable		 2g70B-4m00A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m02 SERINE-RICH ADHESIN
FOR PLATELETS

(Staphylococcus
aureus) 		PF05345
(He_PIG) 		4 GLY A 603
THR A 604
ASP A 601
ASN A 602
 CA  A 701 ( 4.5A)
None
CA  A 701 (-2.2A)
CA  A 701 (-3.0A)
 1.07A 2g70B-4m02A:
undetectable		 2g70B-4m02A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 TYR A 213
TYR A 204
GLY A 241
THR A 239
 None
 1.03A 2g70B-4my0A:
undetectable		 2g70B-4my0A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 TYR A 491
GLY A 442
THR A 489
ASP A 448
 None
 0.96A 2g70B-4pe2A:
undetectable		 2g70B-4pe2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		4 TYR A  62
GLY A  48
THR A  51
ASN A 260
 None
 0.94A 2g70B-4q7qA:
undetectable		 2g70B-4q7qA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 TYR A 317
TYR A 316
GLY A  15
THR A 320
 None
 1.02A 2g70B-4rhhA:
undetectable		 2g70B-4rhhA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 5 TYR B 211
GLY B 200
THR B 213
TYR B 215
ASN B 270
 None
 1.35A 2g70B-4tqoB:
undetectable		 2g70B-4tqoB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 TYR A 429
GLY A 361
THR A 413
ASN A 303
 None
 0.68A 2g70B-4xprA:
undetectable		 2g70B-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 432
TYR A 142
ASP A 430
ASN A 133
 None
 0.86A 2g70B-4z2aA:
undetectable		 2g70B-4z2aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztp HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53
LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  99
TYR L  32
GLY H  99
ASP H  99
 None
 1.02A 2g70B-4ztpH:
undetectable		 2g70B-4ztpH:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 TYR C 259
GLY C 263
THR C 547
ASN C 444
 None
 1.08A 2g70B-5aa5C:
undetectable		 2g70B-5aa5C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeb LRA-12

(uncultured
bacterium BLR12) 		PF00753
(Lactamase_B) 		4 TYR A 236
GLY A 199
TYR A 154
ASP A 139
 None
 1.08A 2g70B-5aebA:
undetectable		 2g70B-5aebA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ca6 PORCINE ROTAVIRUS
TFR-41 VP8*

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 TYR A 189
GLY A 187
THR A 176
TYR A 165
 PLM  A 307 (-3.2A)
None
None
None
 0.77A 2g70B-5ca6A:
undetectable		 2g70B-5ca6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy0 TS3 TOXIN

(Tityus
serrulatus) 		PF00537
(Toxin_3) 		4 TYR A  48
TYR A  37
GLY A   4
TYR A  39
 None
 0.98A 2g70B-5cy0A:
undetectable		 2g70B-5cy0A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		4 GLY A 558
THR A 559
TYR A 532
ASN A 556
 None
 1.03A 2g70B-5emiA:
undetectable		 2g70B-5emiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7l NANOBODY NB-ER14

(Lama glama) 		PF07686
(V-set) 		4 TYR B  98
GLY B  35
THR B  50
TYR B  58
 None
 0.88A 2g70B-5f7lB:
undetectable		 2g70B-5f7lB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		4 TYR A  84
GLY A  68
THR A  70
TYR A  77
 None
 0.95A 2g70B-5f8eA:
13.4		 2g70B-5f8eA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		4 TYR A 255
GLY A 321
THR A 323
TYR A 295
 None
 0.89A 2g70B-5g5nA:
undetectable		 2g70B-5g5nA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 772
THR A 650
ASP A 773
ASN A 587
 None
 1.02A 2g70B-5ju6A:
undetectable		 2g70B-5ju6A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 GLY A 223
THR A 222
ASP A 224
ASN A   4
 None
 0.89A 2g70B-5lv9A:
1.8		 2g70B-5lv9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 TYR B 289
GLY B 137
THR B 138
TYR B 141
 CU  B 701 (-4.7A)
None
None
None
 0.99A 2g70B-5lxzB:
undetectable		 2g70B-5lxzB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLY A  37
THR A  36
ASP A  38
ASN A  58
 None
 0.84A 2g70B-5ngkA:
undetectable		 2g70B-5ngkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 TYR B 625
GLY B 622
THR B 540
ASP B 681
 None
 0.90A 2g70B-5of4B:
undetectable		 2g70B-5of4B:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		4 TYR A  77
THR A 271
TYR A 128
ASN A 279
 None
 0.95A 2g70B-5sv9A:
undetectable		 2g70B-5sv9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1

(Entamoeba
histolytica) 		no annotation 4 TYR C  82
TYR C  64
GLY C  31
TYR C  48
 None
 1.09A 2g70B-5swkC:
undetectable		 2g70B-5swkC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 4 GLY A 194
THR A 198
TYR A 205
ASP A 193
 None
 1.06A 2g70B-5v2mA:
undetectable		 2g70B-5v2mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqj EXO-BETA-1,4-XYLANAS
E

(unidentified) 		no annotation 4 TYR A  80
TYR A 194
GLY A  51
THR A  20
 None
 0.83A 2g70B-5vqjA:
undetectable		 2g70B-5vqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 TYR A 214
GLY A 203
THR A 216
TYR A 218
ASN A 273
 None
 1.38A 2g70B-5xm3A:
undetectable		 2g70B-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L3

(Mycolicibacterium
smegmatis) 		PF00297
(Ribosomal_L3) 		4 GLY D 203
THR D   9
TYR D  54
ASN D 202
 None
 0.97A 2g70B-5xymD:
undetectable		 2g70B-5xymD:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 4 TYR A 278
TYR A  99
GLY A  75
TYR A  86
 None
 0.78A 2g70B-6d3uA:
undetectable		 2g70B-6d3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLY A 348
THR A 347
ASP A 352
ASN A 339
 None
 0.88A 2g70B-6enoA:
undetectable		 2g70B-6enoA:
undetectable