SIMILAR PATTERNS OF AMINO ACIDS FOR 2G70_A_SAMA2001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		5 GLN A 434
LEU C 235
ASP A 375
VAL A 376
ALA A 409
 None
 1.39A 2g70A-1e6vA:
undetectable		 2g70A-1e6vA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		12 TYR A  27
GLN A  86
PHE A 102
LEU A 103
ASP A 158
VAL A 159
HIS A 160
ALA A 181
PHE A 182
CYH A 183
VAL A 187
TYR A 222
 SAH  A2002 (-3.6A)
SAH  A2002 ( 4.2A)
SAH  A2002 (-4.4A)
SAH  A2002 (-3.9A)
SAH  A2002 (-3.6A)
SAH  A2002 (-3.5A)
SAH  A2002 (-4.1A)
SAH  A2002 (-3.3A)
IDI  A3003 ( 3.4A)
SAH  A2002 (-3.4A)
SAH  A2002 (-4.3A)
IDI  A3003 (-3.8A)
 0.48A 2g70A-1n7jA:
47.1		 2g70A-1n7jA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 411
VAL A 345
HIS A 606
PHE A 618
VAL A 610
 None
 1.35A 2g70A-1qjmA:
undetectable		 2g70A-1qjmA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwg (2R)-PHOSPHO-3-SULFO
LACTATE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF02679
(ComA) 		5 GLN A 211
PHE A 230
VAL A 233
ALA A 206
VAL A  18
 None
 1.44A 2g70A-1qwgA:
undetectable		 2g70A-1qwgA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		5 PHE A 101
LEU A  60
ALA A  20
CYH A  18
VAL A  14
 None
 1.35A 2g70A-1tdhA:
undetectable		 2g70A-1tdhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 112
ASP A 107
HIS A 105
ALA A  26
PHE A  27
 None
 1.43A 2g70A-1tf0A:
undetectable		 2g70A-1tf0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 VAL A  57
ALA A 473
PHE A 477
CYH A 475
VAL A 481
 None
 1.15A 2g70A-1tmoA:
undetectable		 2g70A-1tmoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		5 PHE A 482
LEU A 485
VAL A 491
HIS A 481
VAL A 256
 None
 1.15A 2g70A-1vrqA:
undetectable		 2g70A-1vrqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 363
ASP A 237
VAL A 177
ALA A 249
VAL A 350
 LEU  A 363 ( 0.6A)
ASP  A 237 ( 0.5A)
VAL  A 177 ( 0.6A)
ALA  A 249 ( 0.0A)
VAL  A 350 ( 0.6A)
 1.20A 2g70A-1wqaA:
undetectable		 2g70A-1wqaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		5 LEU A 132
ASP A  21
ALA A  76
PHE A  61
CYH A  74
 None
 1.36A 2g70A-1yleA:
undetectable		 2g70A-1yleA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		7 TYR A  11
GLN A  70
PHE A  86
ASP A 142
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.53A 2g70A-2a14A:
36.9		 2g70A-2a14A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		5 LEU A 211
ASP A  39
VAL A  38
VAL A 233
TYR A 248
 None
 1.36A 2g70A-2dg2A:
3.8		 2g70A-2dg2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		5 PHE A 483
LEU A 486
VAL A 492
HIS A 482
VAL A 257
 None
 1.15A 2g70A-2gahA:
undetectable		 2g70A-2gahA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haw MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 LEU A 109
ASP A  96
VAL A  74
HIS A  76
ALA A  34
 None
 1.26A 2g70A-2hawA:
undetectable		 2g70A-2hawA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjn MAINTENANCE OF
PLOIDY PROTEIN MOB1

(Saccharomyces
cerevisiae) 		PF03637
(Mob1_phocein) 		5 TYR A 259
LEU A 279
VAL A 308
PHE A 289
CYH A 287
 None
 1.29A 2g70A-2hjnA:
undetectable		 2g70A-2hjnA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  12
GLN A  71
ASP A 143
VAL A 144
CYH A 166
TYR A 205
 SAH  A4001 (-3.8A)
SAH  A4001 ( 4.3A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.6A)
SAH  A4001 ( 3.8A)
None
 0.37A 2g70A-2i62A:
37.1		 2g70A-2i62A:
37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  11
GLN A  70
ASP A 142
VAL A 143
CYH A 165
TYR A 204
 SAH  A4001 (-3.7A)
SAH  A4001 (-4.1A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
None
 0.46A 2g70A-2iipA:
36.2		 2g70A-2iipA:
36.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mkk CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF16367
(RRM_7) 		5 LEU A 361
VAL A 396
ALA A 410
PHE A 412
VAL A 354
 None
 1.34A 2g70A-2mkkA:
undetectable		 2g70A-2mkkA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU C 142
ASP C  84
VAL C  83
PHE C 154
CYH C 152
 None
 1.34A 2g70A-2nn6C:
undetectable		 2g70A-2nn6C:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 LEU A  18
VAL A 246
ALA A 285
CYH A 295
VAL A 312
 None
 1.33A 2g70A-2nqnA:
undetectable		 2g70A-2nqnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 LEU A 161
ASP A 139
ALA A 261
PHE A  52
VAL A   6
 None
 1.46A 2g70A-2nwhA:
4.0		 2g70A-2nwhA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PHE X 159
LEU X 156
ASP X 229
HIS X 170
CYH X 100
 None
 1.24A 2g70A-2pmoX:
undetectable		 2g70A-2pmoX:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqf POLY [ADP-RIBOSE]
POLYMERASE 12

(Homo sapiens) 		PF00644
(PARP) 		5 TYR A 670
VAL A 674
ALA A 573
CYH A 575
VAL A 532
 None
None
CIT  A 801 ( 4.4A)
None
None
 1.09A 2g70A-2pqfA:
undetectable		 2g70A-2pqfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLN A  80
LEU A  74
VAL A  92
ALA A 110
VAL A  89
 None
 1.39A 2g70A-2xf8A:
3.7		 2g70A-2xf8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ASP A 125
VAL A 122
ALA A  88
CYH A 170
VAL A 167
 None
 1.46A 2g70A-2xymA:
undetectable		 2g70A-2xymA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		5 TYR A 210
LEU A 208
ASP A  79
VAL A  82
ALA A 101
 None
 1.29A 2g70A-2yysA:
undetectable		 2g70A-2yysA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7b MLR6791 PROTEIN

(Mesorhizobium
japonicum) 		PF00596
(Aldolase_II) 		5 TYR A  81
GLN A  56
LEU A  60
ALA A  42
VAL A  90
 None
 1.43A 2g70A-2z7bA:
undetectable		 2g70A-2z7bA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 PHE A 240
LEU A 256
ASP A 239
VAL A 238
ALA A 225
 None
 1.31A 2g70A-3a9xA:
undetectable		 2g70A-3a9xA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		5 PHE A  47
LEU A  93
ASP A  65
VAL A  66
VAL A  41
 None
 1.05A 2g70A-3bwhA:
undetectable		 2g70A-3bwhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck1 PUTATIVE
THIOESTERASE

(Cupriavidus
pinatubonensis) 		PF13279
(4HBT_2) 		5 GLN A  88
LEU A  43
HIS A  51
CYH A 114
VAL A  58
 None
None
GOL  A 155 (-3.8A)
None
GOL  A 155 ( 4.1A)
 1.25A 2g70A-3ck1A:
undetectable		 2g70A-3ck1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A  92
LEU A 114
ASP A 144
VAL A 143
ALA A 133
 None
None
MG  A 701 (-2.9A)
None
None
 1.37A 2g70A-3cmvA:
undetectable		 2g70A-3cmvA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A1092
LEU A1114
ASP A1144
VAL A1143
ALA A1133
 None
None
MG  A1701 (-3.4A)
None
None
 1.39A 2g70A-3cmvA:
undetectable		 2g70A-3cmvA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 VAL A  77
ALA A  43
PHE A  47
CYH A  45
VAL A  56
 None
 1.40A 2g70A-3co1A:
undetectable		 2g70A-3co1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A  40
VAL A 251
HIS A 250
ALA A   9
PHE A  79
 None
 1.35A 2g70A-3d5tA:
4.9		 2g70A-3d5tA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 187
VAL A 227
HIS A 265
ALA A 166
VAL A 269
 None
None
None
HEM  A 500 ( 4.4A)
None
 1.39A 2g70A-3dbgA:
undetectable		 2g70A-3dbgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dto BH2835 PROTEIN

(Bacillus
halodurans) 		PF01966
(HD) 		5 LEU A 180
ASP A 125
VAL A  33
HIS A  29
ALA A 115
 None
 1.14A 2g70A-3dtoA:
undetectable		 2g70A-3dtoA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejf NON-STRUCTURAL
PROTEIN 3

(Avian
coronavirus) 		PF01661
(Macro) 		5 ASP A 117
VAL A 116
CYH A  89
VAL A  79
TYR A  64
 None
 0.97A 2g70A-3ejfA:
undetectable		 2g70A-3ejfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		5 GLN A 235
ASP A  37
VAL A  36
HIS A   0
ALA A 240
 None
 1.36A 2g70A-3ez4A:
undetectable		 2g70A-3ez4A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLN A 288
ASP A 145
VAL A 144
HIS A 143
ALA A 287
 None
 1.35A 2g70A-3gb4A:
undetectable		 2g70A-3gb4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		5 LEU B 172
ASP B 144
ALA B  33
VAL B 184
TYR B  54
 None
 1.15A 2g70A-3gzyB:
undetectable		 2g70A-3gzyB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9j MCCB PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		5 LEU A 319
VAL A 210
ALA A 298
CYH A 302
VAL A 306
 None
 1.39A 2g70A-3h9jA:
4.1		 2g70A-3h9jA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 TYR A  72
LEU A  88
ALA A 101
CYH A 100
TYR A 145
 GOL  A 311 (-3.9A)
None
None
None
None
 1.15A 2g70A-3hc1A:
undetectable		 2g70A-3hc1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihw CENTG3

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 140
ASP A 244
VAL A 241
ALA A 106
VAL A 161
 None
 1.39A 2g70A-3ihwA:
undetectable		 2g70A-3ihwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 213
VAL A 173
ALA A 222
CYH A 221
VAL A 162
 None
 1.34A 2g70A-3k30A:
undetectable		 2g70A-3k30A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqw CG11900

(Drosophila
melanogaster) 		PF13328
(HD_4) 		5 LEU A 169
ASP A 126
VAL A  40
HIS A  36
ALA A 116
 None
None
None
MN  A 300 (-3.5A)
None
 1.40A 2g70A-3nqwA:
undetectable		 2g70A-3nqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 PHE A 341
LEU A 335
ASP A 294
VAL A 295
ALA A 286
 None
 1.25A 2g70A-3qfhA:
undetectable		 2g70A-3qfhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLN A 249
LEU A  23
VAL A   8
ALA A 244
VAL A  80
 None
 1.38A 2g70A-3tl2A:
4.0		 2g70A-3tl2A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 LEU A 193
VAL A 110
ALA A  52
CYH A  27
VAL A  18
 None
 1.42A 2g70A-3tp9A:
undetectable		 2g70A-3tp9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 268
ASP A 294
VAL A 295
ALA A 549
PHE A 548
 None
 1.39A 2g70A-3ue3A:
undetectable		 2g70A-3ue3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ASP A 358
VAL A 354
ALA A 324
CYH A 310
VAL A 284
 None
 1.45A 2g70A-3v98A:
undetectable		 2g70A-3v98A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		5 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.26A 2g70A-3wsuA:
undetectable		 2g70A-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 5 PHE B 328
LEU B 329
ASP B 258
ALA B 318
VAL B 261
 None
 1.12A 2g70A-3x17B:
undetectable		 2g70A-3x17B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 GLN A  30
PHE A 144
LEU A  78
VAL A  26
VAL A 167
 None
 1.38A 2g70A-4bbwA:
undetectable		 2g70A-4bbwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxf RNA POLYMERASE SIGMA
FACTOR CNRH
CNRY

(Cupriavidus
metallidurans;
Cupriavidus
metallidurans) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF17524
(CnrY) 		5 VAL B  14
HIS B  10
ALA A  36
PHE A  40
VAL A 131
 None
 1.43A 2g70A-4cxfB:
undetectable		 2g70A-4cxfB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 227
ASP A 253
VAL A 254
ALA A 508
PHE A 507
 None
 1.34A 2g70A-4fsfA:
undetectable		 2g70A-4fsfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 TYR A 204
LEU A 240
HIS A 171
ALA A 166
CYH A 168
 None
 1.38A 2g70A-4g6cA:
undetectable		 2g70A-4g6cA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 130
VAL A 279
HIS A 313
ALA A 113
VAL A 312
 None
 1.44A 2g70A-4h19A:
undetectable		 2g70A-4h19A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 GLN A 138
ASP A   8
VAL A   7
ALA A 136
VAL A 159
 None
 1.25A 2g70A-4hfoA:
undetectable		 2g70A-4hfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi2 ACYLPHOSPHATASE

(Vibrio cholerae) 		PF00708
(Acylphosphatase) 		5 TYR A  59
LEU A  60
VAL A  71
ALA A  36
VAL A  74
 None
 1.41A 2g70A-4hi2A:
undetectable		 2g70A-4hi2A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl6 UNCHARACTERIZED
PROTEIN YFDE

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 GLN A 148
ASP A  49
VAL A  21
HIS A  20
ALA A 172
 None
 1.28A 2g70A-4hl6A:
undetectable		 2g70A-4hl6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ko2 PERIPLASMIC [NIFESE]
HYDROGENASE SMALL
SUBUNIT

(Desulfomicrobium
baculatum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU S 109
VAL S 145
ALA S 119
PHE S  73
VAL S  76
 None
 1.19A 2g70A-4ko2S:
undetectable		 2g70A-4ko2S:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		5 GLN A 119
PHE A 326
LEU A 239
ALA A 158
VAL A   6
 None
 1.28A 2g70A-4mnmA:
undetectable		 2g70A-4mnmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 GLN A 960
ASP A 909
VAL A 905
ALA A 951
CYH A 928
 None
 1.43A 2g70A-4n3nA:
undetectable		 2g70A-4n3nA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae;
Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB)
PF03116
(NQR2_RnfD_RnfE)
PF02508
(Rnf-Nqr) 		5 TYR E 166
ASP B 397
VAL B 401
HIS B 398
ALA A 410
 None
None
None
RBF  E 201 ( 4.9A)
None
 1.23A 2g70A-4p6vE:
undetectable		 2g70A-4p6vE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Verminephrobacter
eiseniae) 		PF03480
(DctP) 		5 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.34A 2g70A-4p9kA:
undetectable		 2g70A-4p9kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ASP A 281
VAL A 278
HIS A  46
ALA A 123
PHE A 117
 None
 1.27A 2g70A-4pddA:
undetectable		 2g70A-4pddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.33A 2g70A-4pdhA:
undetectable		 2g70A-4pdhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  49
VAL A 277
HIS A 424
ALA A 207
VAL A 274
 None
 1.26A 2g70A-4r1dA:
undetectable		 2g70A-4r1dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN

(Acinetobacter
baumannii) 		no annotation 5 TYR A 108
LEU A 140
ASP A 143
VAL A 104
ALA A 170
 None
 1.45A 2g70A-4rlbA:
undetectable		 2g70A-4rlbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		5 TYR A 264
VAL A  45
ALA A 105
CYH A  18
TYR A 256
 None
 1.31A 2g70A-4uegA:
undetectable		 2g70A-4uegA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		5 GLN A 510
PHE A 295
LEU A 514
ALA A 509
PHE A 268
 None
 1.41A 2g70A-4uooA:
undetectable		 2g70A-4uooA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwh ABC TRANSPORTER

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 149
ASP A 156
VAL A 155
PHE A 185
VAL A 191
 None
 1.31A 2g70A-4wwhA:
undetectable		 2g70A-4wwhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 TYR A  71
GLN A  22
LEU A  63
VAL A  85
VAL A 126
 None
 1.30A 2g70A-4yacA:
undetectable		 2g70A-4yacA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk3 BEPE PROTEIN

(Bartonella
henselae) 		no annotation 5 GLN A 244
LEU A 235
ASP A 193
ALA A 245
VAL A 184
 None
 1.32A 2g70A-4yk3A:
undetectable		 2g70A-4yk3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		5 GLN A 289
LEU A 306
ALA A  99
CYH A 101
VAL A 112
 None
 1.18A 2g70A-4ypvA:
undetectable		 2g70A-4ypvA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 647
LEU A 706
ALA A 623
PHE A 622
VAL A 794
 None
 0.99A 2g70A-4zdnA:
undetectable		 2g70A-4zdnA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		5 VAL A 361
PHE A 397
CYH A 395
VAL A 391
TYR A 419
 None
 1.46A 2g70A-5c6gA:
undetectable		 2g70A-5c6gA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 PHE A 266
ASP A 209
VAL A 210
ALA A 288
CYH A 286
 None
SAH  A 401 ( 4.6A)
None
None
None
 1.33A 2g70A-5cvvA:
12.3		 2g70A-5cvvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 GLN A 290
LEU A 301
ASP A 594
ALA A 324
VAL A 567
 None
 1.37A 2g70A-5cxwA:
undetectable		 2g70A-5cxwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 LEU A  50
ASP A  80
HIS A  37
ALA A  67
VAL A  39
 None
 1.40A 2g70A-5esrA:
undetectable		 2g70A-5esrA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 138
VAL A 448
HIS A 446
ALA A 148
TYR A  63
 None
None
CU  A1465 (-3.3A)
None
None
 1.31A 2g70A-5g3fA:
undetectable		 2g70A-5g3fA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		5 VAL A 100
HIS A 102
ALA A 137
CYH A 133
VAL A 129
 None
NDP  A1265 (-4.9A)
None
None
None
 1.19A 2g70A-5g4lA:
6.5		 2g70A-5g4lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 TYR C 650
GLN A 103
PHE C 651
ASP C 184
ALA C 657
 None
CL  A1229 (-2.6A)
None
None
FAD  B 321 (-4.5A)
 1.44A 2g70A-5g5gC:
undetectable		 2g70A-5g5gC:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 PHE A 444
VAL A 366
ALA B1107
PHE A 347
VAL A 442
 None
 1.45A 2g70A-5ip9A:
undetectable		 2g70A-5ip9A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwr CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 PHE A 195
VAL A 151
ALA A 169
PHE A 166
VAL A 161
 None
 1.32A 2g70A-5jwrA:
undetectable		 2g70A-5jwrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		5 PHE A 279
ASP A 282
VAL A 283
ALA A 384
PHE A 383
 None
None
None
None
PLM  A 513 (-3.7A)
 1.32A 2g70A-5lgdA:
undetectable		 2g70A-5lgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 TYR B 295
LEU B 345
PHE C   7
VAL B 293
TYR C   3
 None
 1.33A 2g70A-5n28B:
undetectable		 2g70A-5n28B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 PHE A 492
LEU A 413
ASP A 483
ALA A 384
PHE A 380
 None
 1.14A 2g70A-5nv6A:
undetectable		 2g70A-5nv6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 GLN A 191
ASP A 295
VAL A 296
ALA A 396
PHE A 397
 None
 1.36A 2g70A-5svcA:
undetectable		 2g70A-5svcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		5 LEU A 297
HIS A 252
ALA A 344
PHE A 369
VAL A 285
 None
 1.39A 2g70A-5tjrA:
undetectable		 2g70A-5tjrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 PHE A 196
LEU A 220
VAL A 127
ALA A  10
VAL A 446
 None
 1.26A 2g70A-5u6sA:
undetectable		 2g70A-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woq TRANSCRIPTIONAL
REGULATOR CLGR

(Mycolicibacterium
smegmatis) 		PF13560
(HTH_31) 		5 ASP A  70
VAL A  67
ALA A  55
CYH A  57
VAL A  62
 None
 1.13A 2g70A-5woqA:
undetectable		 2g70A-5woqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A  88
GLN A 279
LEU A 125
VAL A  30
ALA A 215
 None
 1.43A 2g70A-5xklA:
undetectable		 2g70A-5xklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 GLN A 387
LEU A 364
ALA A 315
CYH A 319
VAL A 323
 None
 1.42A 2g70A-5zb3A:
undetectable		 2g70A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 376
VAL A 351
ALA A 315
CYH A 319
VAL A 323
 None
 1.34A 2g70A-5zb3A:
undetectable		 2g70A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 5 GLN A 381
PHE A  83
LEU A  27
VAL A  80
ALA A 106
 None
 1.20A 2g70A-6c93A:
undetectable		 2g70A-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn7 AEROBACTIN SYNTHASE
IUCC

(Klebsiella
pneumoniae) 		no annotation 5 GLN A 436
PHE A 401
LEU A 397
HIS A 484
ALA A 429
 None
 1.27A 2g70A-6cn7A:
undetectable		 2g70A-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 PHE A 282
LEU A 281
ALA A  10
CYH A 158
VAL A 284
 None
 1.45A 2g70A-6dllA:
undetectable		 2g70A-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 TYR A 333
PHE A 306
LEU A 307
VAL A 470
VAL A 299
 None
 1.20A 2g70A-6fa5A:
undetectable		 2g70A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLN A 103
LEU A  57
ASP A 117
VAL A 111
ALA A  68
 None
 1.43A 2g70A-6fv4A:
undetectable		 2g70A-6fv4A:
undetectable