SIMILAR PATTERNS OF AMINO ACIDS FOR 2FUM_D_MIXD3539_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		3 VAL B  99
VAL B  83
ASP B  71
 None
 0.77A 2fumD-1a6dB:
undetectable		 2fumD-1a6dB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 VAL A 327
VAL A 336
ASP A 381
 None
 0.78A 2fumD-1bk6A:
0.0		 2fumD-1bk6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		3 VAL A 107
VAL A 229
ASP A 271
 None
 0.73A 2fumD-1c4xA:
0.0		 2fumD-1c4xA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		3 VAL A 235
VAL A 180
ASP A 261
 None
 0.74A 2fumD-1c9eA:
0.0		 2fumD-1c9eA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 VAL A   6
VAL A 146
ASP A  81
 None
None
ZN  A 501 (-2.4A)
 0.78A 2fumD-1eqwA:
undetectable		 2fumD-1eqwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		3 VAL A 189
VAL A 292
ASP A 297
 None
 0.74A 2fumD-1ezrA:
0.0		 2fumD-1ezrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		3 VAL A 260
VAL A 253
ASP A  99
 None
 0.77A 2fumD-1ezwA:
undetectable		 2fumD-1ezwA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		3 VAL A 178
VAL A 145
ASP A 155
 None
 0.74A 2fumD-1fhuA:
0.0		 2fumD-1fhuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 VAL P 456
VAL P 453
ASP P 353
 None
None
CA  P 503 ( 2.5A)
 0.78A 2fumD-1h71P:
0.0		 2fumD-1h71P:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 VAL O 221
VAL O 168
ASP O 241
 None
 0.59A 2fumD-1hdgO:
undetectable		 2fumD-1hdgO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		3 VAL A 264
VAL A  31
ASP A 191
 None
 0.77A 2fumD-1hl2A:
undetectable		 2fumD-1hl2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		3 VAL B 140
VAL B 124
ASP B 182
 None
 0.66A 2fumD-1i2mB:
undetectable		 2fumD-1i2mB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		3 VAL A 151
VAL A 104
ASP A  75
 None
 0.74A 2fumD-1i60A:
undetectable		 2fumD-1i60A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 VAL A 200
VAL A  83
ASP A 112
 None
 0.70A 2fumD-1inlA:
2.0		 2fumD-1inlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j4a D-LACTATE
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 VAL A 229
VAL A 232
ASP A 243
 None
 0.72A 2fumD-1j4aA:
undetectable		 2fumD-1j4aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6q CYTOCHROME C
MATURATION PROTEIN E

(Shewanella
putrefaciens) 		PF03100
(CcmE) 		3 VAL A  66
VAL A 111
ASP A  97
 None
 0.70A 2fumD-1j6qA:
undetectable		 2fumD-1j6qA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwe PROTEIN (DNAB
HELICASE)

(Escherichia
coli) 		PF00772
(DnaB) 		3 VAL A 125
VAL A  55
ASP A  43
 None
 0.73A 2fumD-1jweA:
undetectable		 2fumD-1jweA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		3 VAL A 150
VAL A 318
ASP A 361
 None
 0.77A 2fumD-1k8qA:
undetectable		 2fumD-1k8qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A1023
VAL A 273
ASP A 905
 CU  A1055 ( 4.6A)
None
None
 0.71A 2fumD-1kcwA:
undetectable		 2fumD-1kcwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 VAL A 400
VAL A 372
ASP A 331
 None
 0.77A 2fumD-1lnlA:
undetectable		 2fumD-1lnlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 VAL A 191
VAL A 164
ASP A 108
 None
 0.62A 2fumD-1ma1A:
undetectable		 2fumD-1ma1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh9 DNA-BINDING PROTEIN
ALBA

(Methanocaldococcus
jannaschii) 		PF01918
(Alba) 		3 VAL A  44
VAL A  17
ASP A  27
 None
 0.77A 2fumD-1nh9A:
2.3		 2fumD-1nh9A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 VAL D 686
VAL D 689
ASP C 556
 None
 0.73A 2fumD-1o7dD:
0.7		 2fumD-1o7dD:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 VAL A 115
VAL A 111
ASP A 352
 None
 0.67A 2fumD-1pquA:
undetectable		 2fumD-1pquA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 186
VAL A 273
ASP A 242
 None
 0.77A 2fumD-1q1nA:
undetectable		 2fumD-1q1nA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 VAL B 275
VAL B 232
ASP B 245
 None
 0.75A 2fumD-1qs0B:
undetectable		 2fumD-1qs0B:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		3 VAL A 389
VAL A 409
ASP A 274
 None
 0.77A 2fumD-1qw5A:
undetectable		 2fumD-1qw5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1row MSP-DOMAIN PROTEIN
LIKE FAMILY MEMBER

(Caenorhabditis
elegans) 		PF00635
(Motile_Sperm) 		3 VAL A  76
VAL A  48
ASP A  53
 None
 0.74A 2fumD-1rowA:
undetectable		 2fumD-1rowA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 VAL A 387
VAL A 392
ASP A 376
 None
 0.71A 2fumD-1tufA:
undetectable		 2fumD-1tufA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvm PTS SYSTEM,
GALACTITOL-SPECIFIC
IIB COMPONENT

(Escherichia
coli) 		PF02302
(PTS_IIB) 		3 VAL A  79
VAL A  60
ASP A  68
 None
 0.77A 2fumD-1tvmA:
undetectable		 2fumD-1tvmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5s CYTOPLASMIC PROTEIN
NCK2
PINCH PROTEIN

(Homo sapiens) 		PF00018
(SH3_1)
PF00412
(LIM) 		3 VAL B 104
VAL B 100
ASP A  66
 None
 0.74A 2fumD-1u5sB:
undetectable		 2fumD-1u5sB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 VAL A 518
VAL A 521
ASP A 448
 None
 0.77A 2fumD-1v9pA:
undetectable		 2fumD-1v9pA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 VAL A 310
VAL A 295
ASP A 280
 None
 0.74A 2fumD-1vkzA:
undetectable		 2fumD-1vkzA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 VAL B 327
VAL B 336
ASP B 381
 None
 0.73A 2fumD-1wa5B:
undetectable		 2fumD-1wa5B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		3 VAL A 112
VAL A  73
ASP A  85
 None
 0.74A 2fumD-1wl1A:
undetectable		 2fumD-1wl1A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		3 VAL A  29
VAL A 173
ASP A 116
 None
 0.78A 2fumD-1wruA:
2.2		 2fumD-1wruA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 VAL A 251
VAL A 410
ASP A 267
 None
 0.73A 2fumD-1x55A:
undetectable		 2fumD-1x55A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		3 VAL A  96
VAL A 144
ASP A  57
 None
 0.78A 2fumD-1xdzA:
undetectable		 2fumD-1xdzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 VAL A 329
VAL A 324
ASP A 281
 None
 0.66A 2fumD-1yj8A:
undetectable		 2fumD-1yj8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		3 VAL A 212
VAL A  57
ASP A 167
 None
None
ZN  A1446 ( 4.5A)
 0.72A 2fumD-1yloA:
undetectable		 2fumD-1yloA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 VAL A  29
VAL A 175
ASP A 116
 None
None
ZN  A 201 (-2.1A)
 0.68A 2fumD-1z9nA:
undetectable		 2fumD-1z9nA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 VAL A  29
VAL A 175
ASP A 116
 None
None
ZN  A 201 (-2.2A)
 0.66A 2fumD-1z9pA:
undetectable		 2fumD-1z9pA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		3 VAL A 160
VAL A 215
ASP A 110
 None
None
MG  A 501 ( 4.5A)
 0.74A 2fumD-1zcwA:
undetectable		 2fumD-1zcwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A  59
VAL A 120
ASP A  94
 None
 0.76A 2fumD-1zpuA:
undetectable		 2fumD-1zpuA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 VAL A 259
VAL A 322
ASP A 378
 BI1  A1000 (-4.2A)
None
None
 0.69A 2fumD-1zrzA:
24.8		 2fumD-1zrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		3 VAL A  19
VAL A 165
ASP A 106
 None
None
ZN  A 400 (-2.2A)
 0.64A 2fumD-2apsA:
undetectable		 2fumD-2apsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 3 VAL C  38
VAL C 184
ASP C 125
 None
None
ZN  C 201 (-2.2A)
 0.62A 2fumD-2aqtC:
undetectable		 2fumD-2aqtC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		3 VAL A 281
VAL A 311
ASP A 296
 None
 0.71A 2fumD-2bcoA:
undetectable		 2fumD-2bcoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		3 VAL A 542
VAL A 482
ASP A 515
 None
 0.72A 2fumD-2bf6A:
undetectable		 2fumD-2bf6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		3 VAL A 507
VAL A 658
ASP A 487
 None
None
CO  A1685 ( 4.8A)
 0.78A 2fumD-2c79A:
undetectable		 2fumD-2c79A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 VAL A 403
VAL A 421
ASP A  50
 None
 0.71A 2fumD-2c7zA:
undetectable		 2fumD-2c7zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfe RIBONUCLEASE HII

(Thermococcus
kodakarensis) 		PF01351
(RNase_HII) 		3 VAL A  23
VAL A 141
ASP A 153
 None
 0.72A 2fumD-2dfeA:
undetectable		 2fumD-2dfeA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dld D-LACTATE
DEHYDROGENASE

(Lactobacillus
helveticus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 VAL A 229
VAL A 232
ASP A 243
 None
 0.70A 2fumD-2dldA:
undetectable		 2fumD-2dldA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmg KIAA1228 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		3 VAL A  66
VAL A  48
ASP A 107
 None
 0.68A 2fumD-2dmgA:
undetectable		 2fumD-2dmgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 VAL A  48
VAL A  34
ASP A 379
 None
 0.78A 2fumD-2dw6A:
undetectable		 2fumD-2dw6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		3 VAL A 223
VAL A 241
ASP A 260
 None
MLY  A 238 (-3.8A)
EDO  A  13 (-2.9A)
 0.65A 2fumD-2etvA:
undetectable		 2fumD-2etvA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 VAL A  53
VAL A  74
ASP A  69
 None
 0.72A 2fumD-2f43A:
undetectable		 2fumD-2f43A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 VAL A  61
VAL A 143
ASP A 107
 None
 0.62A 2fumD-2fa0A:
undetectable		 2fumD-2fa0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		3 VAL A  28
VAL A 396
ASP A 127
 None
 0.75A 2fumD-2ftwA:
undetectable		 2fumD-2ftwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9d SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio cholerae) 		PF04952
(AstE_AspA) 		3 VAL A 281
VAL A 311
ASP A 296
 None
 0.76A 2fumD-2g9dA:
undetectable		 2fumD-2g9dA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT
HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF04268
(SoxG)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		3 VAL A 205
VAL A 133
ASP C 142
 NAD  A 999 (-4.1A)
None
None
 0.77A 2fumD-2gahA:
undetectable		 2fumD-2gahA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grv LPQW

(Mycolicibacterium
smegmatis) 		PF00496
(SBP_bac_5) 		3 VAL A 444
VAL A 403
ASP A 419
 None
 0.78A 2fumD-2grvA:
2.6		 2fumD-2grvA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 VAL N 223
VAL N 110
ASP N 101
 None
 0.78A 2fumD-2gtlN:
undetectable		 2fumD-2gtlN:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 517
VAL A 521
ASP A 368
 None
 0.61A 2fumD-2gv9A:
undetectable		 2fumD-2gv9A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		3 VAL A 845
VAL A 827
ASP A 803
 None
 0.78A 2fumD-2hg4A:
undetectable		 2fumD-2hg4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 VAL A 298
VAL A 160
ASP A 168
 None
 0.71A 2fumD-2hlpA:
undetectable		 2fumD-2hlpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		3 VAL A 209
VAL A 207
ASP A 187
 None
 0.77A 2fumD-2hlsA:
undetectable		 2fumD-2hlsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A 116
VAL A  38
ASP A  80
 None
 0.74A 2fumD-2hneA:
undetectable		 2fumD-2hneA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4a THIOREDOXIN

(Acetobacter
aceti) 		PF00085
(Thioredoxin) 		3 VAL A   7
VAL A  55
ASP A  83
 None
 0.77A 2fumD-2i4aA:
undetectable		 2fumD-2i4aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 VAL A 323
VAL A 177
ASP A  15
 None
 0.70A 2fumD-2i5gA:
undetectable		 2fumD-2i5gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibo HYPOTHETICAL PROTEIN
SP2199

(Streptococcus
pneumoniae) 		PF01910
(Thiamine_BP) 		3 VAL A  34
VAL A  44
ASP A  23
 None
 0.78A 2fumD-2iboA:
undetectable		 2fumD-2iboA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		3 VAL A 254
VAL A 251
ASP A 196
 ATP  A1327 ( 3.6A)
None
None
 0.78A 2fumD-2ivpA:
undetectable		 2fumD-2ivpA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		3 VAL A 269
VAL A 337
ASP A 318
 None
 0.52A 2fumD-2jjqA:
undetectable		 2fumD-2jjqA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 VAL A 242
VAL A 272
ASP A 229
 None
 0.77A 2fumD-2jk0A:
undetectable		 2fumD-2jk0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 VAL A  47
VAL A 191
ASP A 127
 None
None
ZN  A 226 (-2.1A)
 0.69A 2fumD-2jlpA:
undetectable		 2fumD-2jlpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klr ALPHA-CRYSTALLIN B
CHAIN

(Homo sapiens) 		PF00011
(HSP20) 		3 VAL A 128
VAL A  97
ASP A  80
 None
 0.77A 2fumD-2klrA:
undetectable		 2fumD-2klrA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ky4 PHYCOBILISOME LINKER
POLYPEPTIDE

(Nostoc sp. PCC
7120) 		PF00427
(PBS_linker_poly) 		3 VAL A 134
VAL A   3
ASP A  12
 None
 0.76A 2fumD-2ky4A:
undetectable		 2fumD-2ky4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m3d NUCLEOLAR RNA
HELICASE 2

(Homo sapiens) 		PF08152
(GUCT) 		3 VAL A  22
VAL A  19
ASP A  10
 None
 0.62A 2fumD-2m3dA:
undetectable		 2fumD-2m3dA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9u INTEGRASE P46

(Murine leukemia
virus) 		no annotation 3 VAL A  44
VAL A  10
ASP A  60
 None
 0.75A 2fumD-2m9uA:
undetectable		 2fumD-2m9uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpo MIC2-ASSOCIATED
PROTEIN

(Toxoplasma
gondii) 		no annotation 3 VAL A 158
VAL A  36
ASP A 126
 None
 0.66A 2fumD-2mpoA:
undetectable		 2fumD-2mpoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 VAL A 262
VAL A 259
ASP A 413
 VAL  A 262 ( 0.6A)
VAL  A 259 ( 0.6A)
ASP  A 413 (-0.5A)
 0.78A 2fumD-2nvvA:
undetectable		 2fumD-2nvvA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 VAL A 205
VAL A 250
ASP A 149
 None
None
ADP  A 301 (-3.9A)
 0.75A 2fumD-2o1vA:
undetectable		 2fumD-2o1vA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 VAL A 205
VAL A 250
ASP A 149
 None
 0.72A 2fumD-2o1wA:
undetectable		 2fumD-2o1wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 VAL A 266
VAL A 240
ASP A 180
 None
 0.70A 2fumD-2oejA:
undetectable		 2fumD-2oejA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4v TRANSCRIPTION
ELONGATION FACTOR
GREB

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		3 VAL A  91
VAL A 133
ASP A  96
 None
 0.71A 2fumD-2p4vA:
undetectable		 2fumD-2p4vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 VAL A  73
VAL A 155
ASP A 119
 None
 0.55A 2fumD-2p8uA:
undetectable		 2fumD-2p8uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 VAL A 181
VAL A 184
ASP A 130
 None
 0.74A 2fumD-2puzA:
undetectable		 2fumD-2puzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		3 VAL A  79
VAL A  42
ASP A 143
 None
 0.64A 2fumD-2qagA:
undetectable		 2fumD-2qagA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 VAL A 238
VAL A 242
ASP A  23
 None
 0.63A 2fumD-2qkxA:
undetectable		 2fumD-2qkxA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		3 VAL A 181
VAL A 201
ASP A 285
 None
 0.72A 2fumD-2qpqA:
1.3		 2fumD-2qpqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 VAL A 872
VAL A 867
ASP A 933
 None
 0.75A 2fumD-2r2pA:
18.7		 2fumD-2r2pA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9g AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C) 		3 VAL A 320
VAL A 299
ASP A 271
 None
 0.78A 2fumD-2r9gA:
undetectable		 2fumD-2r9gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS

(Pyrobaculum
aerophilum) 		PF00571
(CBS) 		3 VAL A  50
VAL A  48
ASP A  82
 AMP  A 301 ( 4.9A)
None
None
 0.74A 2fumD-2rifA:
undetectable		 2fumD-2rifA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 VAL G1015
VAL G1018
ASP G1001
 None
 0.74A 2fumD-2uv8G:
undetectable		 2fumD-2uv8G:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A 186
VAL A 192
ASP A 199
 None
 0.75A 2fumD-2vd5A:
23.2		 2fumD-2vd5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 VAL A 350
VAL A 327
ASP A 236
 None
None
MGD  A1766 (-2.6A)
 0.73A 2fumD-2vpwA:
undetectable		 2fumD-2vpwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 VAL A  25
VAL A 397
ASP A 128
 None
 0.71A 2fumD-2vr2A:
undetectable		 2fumD-2vr2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		3 VAL A  94
VAL A 213
ASP A 224
 None
 0.77A 2fumD-2vvtA:
undetectable		 2fumD-2vvtA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 VAL A 666
VAL A 661
ASP A 539
 None
 0.76A 2fumD-2vxoA:
undetectable		 2fumD-2vxoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 VAL A 110
VAL A 192
ASP A 156
 None
 0.58A 2fumD-2wyaA:
undetectable		 2fumD-2wyaA:
21.37