SIMILAR PATTERNS OF AMINO ACIDS FOR 2FUM_C_MIXC2539_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		6 MET A 162
VAL A 165
THR A 169
ASN A 218
MET A 220
ASP A 232
 AMP  A 425 (-4.4A)
AMP  A 425 (-4.0A)
AMP  A 425 ( 4.3A)
None
AMP  A 425 ( 4.0A)
AMP  A 425 (-2.7A)
 0.73A 2fumC-1cjaA:
5.7		 2fumC-1cjaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  70
GLY A  71
VAL A  78
ALA A  91
MET A 138
ASN A 191
 STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-3.2A)
STU  A 401 (-4.5A)
 0.54A 2fumC-1nxkA:
21.6		 2fumC-1nxkA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
VAL A  86
ALA A  99
MET A 147
ASN A 199
ASP A 212
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
MG  A 536 (-2.8A)
MG  A 536 (-3.3A)
 0.76A 2fumC-1s9iA:
20.5		 2fumC-1s9iA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
GLY A 596
VAL A 603
ALA A 621
TYR A 672
ASN A 797
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
None
 0.50A 2fumC-1t46A:
17.7		 2fumC-1t46A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 414
ASN A 466
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.2A)
 0.63A 2fumC-1u59A:
24.9		 2fumC-1u59A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
ASN A 156
 None
 0.48A 2fumC-1u5qA:
26.4		 2fumC-1u5qA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
ASN A 135
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
 0.47A 2fumC-1zltA:
23.1		 2fumC-1zltA:
26.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 605
GLY A 606
VAL A 613
ALA A 626
MET A 788
TYR A 790
ASN A 840
 None
None
None
GOL  A 998 ( 3.7A)
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
None
 0.92A 2fumC-1zy4A:
22.8		 2fumC-1zy4A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
GOL  A3001 (-4.4A)
 0.87A 2fumC-2a2aA:
25.2		 2fumC-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU X  17
GLY X  18
VAL X  25
ALA X  37
TYR X  84
ASN X 135
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.9A)
 0.57A 2fumC-2dq7X:
25.6		 2fumC-2dq7X:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
ASN A 156
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 (-4.5A)
STU  A 400 (-4.4A)
 0.49A 2fumC-2gcdA:
27.3		 2fumC-2gcdA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
ASN A 391
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.9A)
 0.83A 2fumC-2h8hA:
24.6		 2fumC-2h8hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
GLY A 349
VAL A 356
ALA A 369
TYR A 422
VAL A 423
 PDS  A 901 (-3.9A)
PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
 0.72A 2fumC-2i0eA:
24.1		 2fumC-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 348
VAL A 356
ALA A 369
TYR A 422
VAL A 423
ASN A 471
MET A 473
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
 0.68A 2fumC-2i0eA:
24.1		 2fumC-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A 101
ASN A 149
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-3.9A)
None
 0.78A 2fumC-2jamA:
21.4		 2fumC-2jamA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ALA A 367
MET A 414
ASN A 466
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.3A)
MG  A 614 ( 3.2A)
 0.80A 2fumC-2ozoA:
23.5		 2fumC-2ozoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU X  70
GLY X  71
VAL X  78
ALA X  91
MET X 138
ASN X 191
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
 0.75A 2fumC-2p3gX:
19.9		 2fumC-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
TYR A 566
ASN A 631
ASP A 644
 None
 0.75A 2fumC-2psqA:
24.9		 2fumC-2psqA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
 0.90A 2fumC-2w4kA:
25.3		 2fumC-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
GLY A  53
VAL A  60
ALA A  73
VAL A 121
ASN A 169
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-3.9A)
None
DKI  A1338 (-3.8A)
 0.86A 2fumC-2w4oA:
23.8		 2fumC-2w4oA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
GLY A 113
VAL A 120
ALA A 133
MET A 180
TYR A 182
ASN A 232
 16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
None
 0.69A 2fumC-2x4fA:
25.4		 2fumC-2x4fA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
GLY A 113
VAL A 120
ALA A 133
MET A 180
TYR A 182
VAL A 183
 16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
 0.55A 2fumC-2x4fA:
25.4		 2fumC-2x4fA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
ASN A 145
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
 0.69A 2fumC-2xikA:
20.8		 2fumC-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
 0.80A 2fumC-2yabA:
25.5		 2fumC-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
ALA A 121
TYR A 174
ASN A 223
MET A 225
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 (-4.7A)
None
STU  A 400 (-3.6A)
 1.04A 2fumC-3a62A:
25.9		 2fumC-3a62A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
MET A 146
 4RB  A 401 ( 3.9A)
4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 4.1A)
4RB  A 401 (-2.8A)
 0.82A 2fumC-3bqrA:
24.5		 2fumC-3bqrA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 4.1A)
None
4RB  A 401 (-2.8A)
 0.81A 2fumC-3bqrA:
24.5		 2fumC-3bqrA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  29
GLY A  30
VAL A  37
ALA A  50
MET A 100
ASN A 151
 None
 0.67A 2fumC-3dxnA:
26.7		 2fumC-3dxnA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  29
VAL A  37
ALA A  50
MET A 100
ASN A 151
ASP A 167
 None
 0.77A 2fumC-3dxnA:
26.7		 2fumC-3dxnA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		6 LEU A  26
GLY A  27
VAL A  33
TYR A  87
ASN A 183
ASP A 195
 None
 0.85A 2fumC-3dxqA:
8.3		 2fumC-3dxqA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
ASN A 184
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
STU  A   1 ( 4.9A)
 0.59A 2fumC-3fmeA:
23.8		 2fumC-3fmeA:
28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 210
VAL A 217
ALA A 228
MET A 279
TYR A 281
ASN A 338
 ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
None
MG  A 901 ( 2.8A)
 0.85A 2fumC-3g2fA:
23.5		 2fumC-3g2fA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 833
GLY A 834
VAL A 841
ALA A 859
TYR A 911
ASN A1027
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
None
 0.73A 2fumC-3hngA:
24.1		 2fumC-3hngA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.80A 2fumC-3hztA:
22.1		 2fumC-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2fumC-3lm5A:
25.8		 2fumC-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 171
GLY A 172
VAL A 179
ALA A 192
TYR A 242
ASN A 291
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-3.9A)
 0.61A 2fumC-3mtlA:
23.0		 2fumC-3mtlA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  49
GLY A  50
VAL A  57
ALA A  70
MET A 120
TYR A 122
VAL A 123
ASN A 171
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.2A)
None
 0.51A 2fumC-3mvjA:
25.2		 2fumC-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
GLY A  89
VAL A  96
ALA A 109
TYR A 161
ASN A 210
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
 0.61A 2fumC-3nuuA:
26.4		 2fumC-3nuuA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		6 LEU A 156
GLY A 157
VAL A 164
ALA A 177
MET A 227
TYR A 229
 LEU  A 156 ( 0.6A)
GLY  A 157 ( 0.0A)
VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
MET  A 227 ( 0.0A)
TYR  A 229 ( 1.3A)
 0.71A 2fumC-3o96A:
24.2		 2fumC-3o96A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 LEU A 348
GLY A 349
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 (-4.0A)
 0.81A 2fumC-3pfqA:
22.8		 2fumC-3pfqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		8 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
ASN A 471
MET A 473
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 (-4.0A)
ANP  A 800 ( 4.5A)
ANP  A 800 ( 4.6A)
 0.88A 2fumC-3pfqA:
22.8		 2fumC-3pfqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASN A 850
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.0A)
 0.81A 2fumC-3pp0A:
24.1		 2fumC-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  21
GLY A  22
VAL A  29
ALA A  42
MET A  96
TYR A  98
 None
 0.85A 2fumC-3qa8A:
20.9		 2fumC-3qa8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  50
GLY A  51
VAL A  58
ALA A  71
MET A 118
ASN A 171
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
I85  A 350 (-4.4A)
 0.40A 2fumC-3sheA:
20.9		 2fumC-3sheA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
GLY A 362
VAL A 369
ALA A 382
MET A 433
VAL A 436
ASN A 484
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
None
 0.70A 2fumC-3txoA:
18.3		 2fumC-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
ASN A 421
ASP A 434
 None
 0.96A 2fumC-3ulzA:
20.3		 2fumC-3ulzA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
GLY A 140
VAL A 147
ALA A 160
TYR A 212
THR A 217
ASN A 261
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
None
None
 0.64A 2fumC-3w18A:
10.4		 2fumC-3w18A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
VAL A  83
ALA A  96
MET A 144
ASN A 196
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
 0.79A 2fumC-3wigA:
25.6		 2fumC-3wigA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
ASN A 206
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
None
 0.70A 2fumC-4aw2A:
22.9		 2fumC-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
ASN A 144
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
 0.77A 2fumC-4cfhA:
26.8		 2fumC-4cfhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
ALA A 684
MET A 737
TYR A 739
ASN A 787
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
MG  A1986 ( 3.2A)
 0.52A 2fumC-4crsA:
24.6		 2fumC-4crsA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		6 LEU A  16
GLY A  17
VAL A  24
ALA A  37
MET A  87
TYR A  89
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.4A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.6A)
ANP  A 300 (-4.3A)
 0.69A 2fumC-4eqmA:
29.9		 2fumC-4eqmA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		7 LEU A  16
VAL A  24
ALA A  37
MET A  87
TYR A  89
THR A  94
ASN A 138
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.6A)
ANP  A 300 (-4.3A)
None
None
 0.72A 2fumC-4eqmA:
29.9		 2fumC-4eqmA:
40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
ASN A 140
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.7A)
None
 0.79A 2fumC-4euuA:
24.4		 2fumC-4euuA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  65
VAL A  72
ALA A  88
MET A 134
TYR A 136
ASN A 182
 ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 ( 3.9A)
ADP  A 601 (-4.1A)
MG  A 602 ( 2.6A)
 0.70A 2fumC-4f99A:
16.1		 2fumC-4f99A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
VAL A  34
ALA A  47
MET A  95
VAL A  98
ASN A 146
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.9A)
ATP  A 401 (-3.4A)
 0.70A 2fumC-4fg8A:
25.4		 2fumC-4fg8A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ALA A 400
MET A 448
ASN A 499
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
 0.72A 2fumC-4fl3A:
24.3		 2fumC-4fl3A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
GLY A 856
VAL A 863
ALA A 880
MET A 929
ASN A 981
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
 0.79A 2fumC-4gl9A:
24.1		 2fumC-4gl9A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
GLY A 856
VAL A 863
ALA A 880
MET A 929
TYR A 931
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
None
 0.68A 2fumC-4gl9A:
24.1		 2fumC-4gl9A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 156
GLY A 157
VAL A 164
ALA A 177
MET A 227
TYR A 229
MET A 281
ASP A 292
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.5A)
0XZ  A 501 ( 3.4A)
 0.87A 2fumC-4gv1A:
25.4		 2fumC-4gv1A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 156
VAL A 164
ALA A 177
MET A 227
TYR A 229
ASN A 279
MET A 281
ASP A 292
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 (-3.5A)
0XZ  A 501 ( 3.4A)
 0.86A 2fumC-4gv1A:
25.4		 2fumC-4gv1A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
GLY A 829
VAL A 836
ALA A 853
MET A 902
TYR A 904
ASN A 954
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
None
 0.45A 2fumC-4hviA:
18.0		 2fumC-4hviA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
GLY A 407
VAL A 414
ALA A 427
MET A 469
ASN A 520
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 ( 4.9A)
 0.71A 2fumC-4idtA:
24.8		 2fumC-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
ASN A 140
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.4A)
None
 0.78A 2fumC-4jlcA:
20.9		 2fumC-4jlcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
ASN A 391
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
 0.77A 2fumC-4k11A:
24.4		 2fumC-4k11A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
TYR A 340
ASN A 391
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-3.1A)
 0.71A 2fumC-4k11A:
24.4		 2fumC-4k11A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
GLY A 479
VAL A 486
ALA A 506
TYR A 557
ASN A 622
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
MG  A 802 ( 2.4A)
 0.59A 2fumC-4k33A:
18.4		 2fumC-4k33A:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  43
VAL A  50
ALA A  61
MET A 104
TYR A 106
ASN A 161
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
None
 0.39A 2fumC-4l52A:
25.2		 2fumC-4l52A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
GLY A  34
VAL A  41
ALA A  54
MET A  99
TYR A 101
 GOL  A 404 ( 3.6A)
None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
 0.52A 2fumC-4lg4A:
19.3		 2fumC-4lg4A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
 0.49A 2fumC-4oliA:
24.7		 2fumC-4oliA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
MET A  95
VAL A  98
ASN A 146
ASP A 159
 None
 0.60A 2fumC-4ow8A:
31.8		 2fumC-4ow8A:
41.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 345
GLY A 346
VAL A 353
ALA A 366
TYR A 419
VAL A 420
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.3A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
 0.70A 2fumC-4ra4A:
23.9		 2fumC-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 345
VAL A 353
ALA A 366
TYR A 419
VAL A 420
MET A 470
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.80A 2fumC-4ra4A:
23.9		 2fumC-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 353
ALA A 366
TYR A 419
VAL A 420
ASN A 468
MET A 470
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.83A 2fumC-4ra4A:
23.9		 2fumC-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
 None
 0.81A 2fumC-4redA:
21.6		 2fumC-4redA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
ASN A 146
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
 0.74A 2fumC-4rewA:
26.6		 2fumC-4rewA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 LEU A 104
GLY A 105
VAL A 112
ALA A 125
MET A 175
TYR A 177
VAL A 178
ASN A 226
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.2A)
ZN  A 502 ( 2.5A)
 0.54A 2fumC-4wb7A:
25.5		 2fumC-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 577
VAL A 586
ALA A 597
THR A 648
ASN A 693
ASP A 711
 None
 0.83A 2fumC-4z7gA:
21.9		 2fumC-4z7gA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
ASN A 628
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.0A)
 0.82A 2fumC-5a46A:
23.7		 2fumC-5a46A:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
ASN A 143
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
GOL  A 404 ( 4.6A)
GOL  A 404 (-3.2A)
 0.66A 2fumC-5ci7A:
26.2		 2fumC-5ci7A:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
 0.49A 2fumC-5f1zA:
24.3		 2fumC-5f1zA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
GLY A 904
VAL A 911
VAL A 981
ASN A1028
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 ( 4.9A)
 0.78A 2fumC-5f1zA:
24.3		 2fumC-5f1zA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
GLY A 600
VAL A 607
ALA A 625
TYR A 676
ASN A 823
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
None
 0.53A 2fumC-5grnA:
17.7		 2fumC-5grnA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
MG  A 302 ( 2.8A)
 0.45A 2fumC-5hu3A:
28.6		 2fumC-5hu3A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
ALA A  77
MET A 130
TYR A 132
ASN A 185
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.1A)
 0.62A 2fumC-5i3oA:
24.4		 2fumC-5i3oA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
ASN A 144
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.3A)
 0.57A 2fumC-5isoA:
26.3		 2fumC-5isoA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 LEU A  18
GLY A  19
VAL A  26
ALA A  39
MET A  89
TYR A  91
 None
 0.73A 2fumC-5m09A:
25.8		 2fumC-5m09A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
MET A  89
TYR A  91
VAL A  92
 None
 0.82A 2fumC-5m09A:
25.8		 2fumC-5m09A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 11 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
TYR A  94
VAL A  95
THR A  99
ASN A 143
MET A 145
MET A 155
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
 0.54A 2fumC-5u94A:
38.0		 2fumC-5u94A:
84.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
GLY A 687
VAL A 694
ALA A 707
MET A 754
VAL A 757
ASN A 808
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 4.0A)
 0.51A 2fumC-5vilA:
20.2		 2fumC-5vilA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
GLY A 892
VAL A 899
ALA A 917
TYR A 965
ASN A1015
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
MG  A1202 ( 2.9A)
 0.69A 2fumC-5wnoA:
22.1		 2fumC-5wnoA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
TYR A 965
ASN A1015
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
MG  A1202 ( 2.9A)
MG  A1202 ( 3.0A)
 0.45A 2fumC-5wnoA:
22.1		 2fumC-5wnoA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LEU A  33
GLY A  34
VAL A  41
ALA A  54
MET A  99
TYR A 101
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.5A)
ANP  A 501 ( 4.2A)
 0.74A 2fumC-6ao5A:
10.8		 2fumC-6ao5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
VAL A  41
ALA A  54
MET A  99
TYR A 101
ASN A 151
ASP A 164
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.5A)
ANP  A 501 ( 4.2A)
ANP  A 501 ( 2.6A)
MG  A 502 ( 3.1A)
 0.91A 2fumC-6ao5A:
10.8		 2fumC-6ao5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 LEU A  22
ALA A  43
MET A  93
TYR A  95
VAL A  96
ASN A 144
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
None
 0.78A 2fumC-6bx6A:
22.4		 2fumC-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
VAL A  96
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
 0.63A 2fumC-6bx6A:
22.4		 2fumC-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
 EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
 0.71A 2fumC-6bx6A:
22.4		 2fumC-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 LEU A 366
GLY A 367
VAL A 374
ALA A 388
MET A 438
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
EE4  A 701 ( 3.8A)
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.64A 2fumC-6c0tA:
19.4		 2fumC-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
GLY A 882
VAL A 889
ALA A 906
MET A 956
ASN A1008
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
MG  A1202 ( 2.5A)
 0.61A 2fumC-6c7yA:
15.1		 2fumC-6c7yA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 GLY A  67
VAL A  74
ALA A  87
MET A 136
TYR A 138
ASN A 187
 None
 0.59A 2fumC-6c9dA:
25.2		 2fumC-6c9dA:
15.44