SIMILAR PATTERNS OF AMINO ACIDS FOR 2FUM_B_MIXB1539

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  70
GLY A  71
VAL A  78
ALA A  91
MET A 138
LYS A 188
ASN A 191
ASP A 207
 STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.5A)
STU  A 401 (-3.6A)
 0.76A 2fumB-1nxkA:
23.4		 2fumB-1nxkA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 414
ASN A 466
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.2A)
STU  A 100 (-3.5A)
 0.59A 2fumB-1u59A:
26.9		 2fumB-1u59A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
LYS A 153
ASN A 156
ASP A 169
 None
 0.74A 2fumB-1u5qA:
27.5		 2fumB-1u5qA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
LYS A 132
ASN A 135
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-3.9A)
 0.69A 2fumB-1zltA:
25.3		 2fumB-1zltA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
 None
 0.97A 2fumB-1zwsA:
27.0		 2fumB-1zwsA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
ASN A 144
MET A 146
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
None
GOL  A3001 (-4.4A)
None
 0.77A 2fumB-2a2aA:
27.0		 2fumB-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
None
None
 0.62A 2fumB-2a2aA:
27.0		 2fumB-2a2aA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
VAL X  25
ALA X  37
TYR X  84
ASN X 135
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.9A)
STU  X 902 (-3.6A)
 0.55A 2fumB-2dq7X:
27.3		 2fumB-2dq7X:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
LYS A 153
ASN A 156
ASP A 169
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 (-4.5A)
None
STU  A 400 (-4.4A)
STU  A 400 (-3.6A)
 0.77A 2fumB-2gcdA:
28.6		 2fumB-2gcdA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		10 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
LYS A 468
ASN A 471
MET A 473
ASP A 484
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.8A)
PDS  A 901 (-4.7A)
PDS  A 901 (-4.3A)
None
PDS  A 901 (-4.3A)
PDS  A 901 (-3.6A)
PDS  A 901 (-3.6A)
 0.80A 2fumB-2i0eA:
25.8		 2fumB-2i0eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A 101
ASN A 149
ASP A 165
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-3.9A)
None
J60  A1305 ( 3.6A)
 0.90A 2fumB-2jamA:
20.9		 2fumB-2jamA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY X  71
VAL X  78
ALA X  91
MET X 138
LYS X 188
ASN X 191
ASP X 207
 F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
None
F10  X 401 (-3.4A)
 0.79A 2fumB-2p3gX:
21.1		 2fumB-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU X  70
GLY X  71
VAL X  78
ALA X  91
MET X 138
LYS X 188
ASN X 191
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
None
 0.78A 2fumB-2p3gX:
21.1		 2fumB-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ASN A 631
ASP A 644
 None
 1.04A 2fumB-2psqA:
26.5		 2fumB-2psqA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
MET A 153
TYR A 155
LYS A 200
ASN A 203
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 (-2.9A)
MG  A1481 (-3.5A)
 0.69A 2fumB-2v55A:
23.0		 2fumB-2v55A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
MET A 146
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
MG  A1304 ( 4.2A)
ADP  A1303 (-4.2A)
MG  A1304 ( 2.8A)
 0.85A 2fumB-2w4kA:
27.1		 2fumB-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-3.6A)
None
MG  A1304 ( 4.2A)
MG  A1304 ( 2.8A)
 0.81A 2fumB-2w4kA:
27.1		 2fumB-2w4kA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
GLY A 113
VAL A 120
ALA A 133
MET A 180
TYR A 182
ASN A 232
 16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
None
 0.66A 2fumB-2x4fA:
27.4		 2fumB-2x4fA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
GLY A 113
VAL A 120
ALA A 133
MET A 180
TYR A 182
VAL A 183
 16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
 0.41A 2fumB-2x4fA:
27.4		 2fumB-2x4fA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
VAL A 120
ALA A 133
MET A 180
TYR A 182
ASN A 232
ASP A 247
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
None
None
 0.83A 2fumB-2x4fA:
27.4		 2fumB-2x4fA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 112
VAL A 120
ALA A 133
MET A 180
TYR A 182
VAL A 183
ASP A 247
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.2A)
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
None
 0.77A 2fumB-2x4fA:
27.4		 2fumB-2x4fA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  27
VAL A  34
ALA A  47
MET A  95
TYR A  97
LYS A 142
ASN A 145
ASP A 158
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.5A)
None
None
J60  A1294 ( 4.6A)
 0.68A 2fumB-2xikA:
22.0		 2fumB-2xikA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
MET A 146
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
 0.69A 2fumB-2yabA:
27.2		 2fumB-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
MET A 146
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
None
AMP  A1302 ( 4.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-3.1A)
 0.77A 2fumB-2yabA:
27.2		 2fumB-2yabA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A 189
ASN A 192
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
STU  A   1 ( 3.8A)
 0.70A 2fumB-2z7rA:
20.3		 2fumB-2z7rA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  97
GLY A  98
VAL A 105
ALA A 121
TYR A 174
LYS A 220
ASN A 223
MET A 225
ASP A 236
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 (-4.7A)
None
None
STU  A 400 (-3.6A)
STU  A 400 ( 3.8A)
 1.01A 2fumB-3a62A:
26.8		 2fumB-3a62A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ASN A 628
ASP A 641
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.5A)
 1.10A 2fumB-3c4fA:
24.5		 2fumB-3c4fA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
MET A 100
LYS A 148
ASN A 151
 None
 0.69A 2fumB-3dxnA:
27.6		 2fumB-3dxnA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU X  46
GLY X  47
VAL X  54
TYR X 116
LYS X 159
ASN X 162
MET X 164
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.9A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-4.3A)
None
None
CCK  X 351 (-3.5A)
 0.95A 2fumB-3e3bX:
24.0		 2fumB-3e3bX:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A 119
ASN A 171
ASP A 185
 DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.6A)
DRK  A 384 ( 4.7A)
 1.02A 2fumB-3eb0A:
25.4		 2fumB-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
MET A 117
TYR A 119
ASN A 171
ASP A 185
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.6A)
DRK  A 384 ( 4.7A)
 0.89A 2fumB-3eb0A:
25.4		 2fumB-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A 169
ASN A 172
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
985  A   1 (-4.6A)
985  A   1 ( 4.0A)
 0.88A 2fumB-3f2aA:
21.2		 2fumB-3f2aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
LYS A 181
ASN A 184
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
None
STU  A   1 ( 4.9A)
 0.63A 2fumB-3fmeA:
23.5		 2fumB-3fmeA:
28.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
MET A 153
ASN A 204
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 ( 3.0A)
GOL  A 542 ( 4.8A)
J60  A 540 ( 3.6A)
 0.62A 2fumB-3hztA:
23.3		 2fumB-3hztA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  68
VAL A  76
ALA A  89
MET A 138
LYS A 186
ASN A 189
ASP A 205
 ANP  A 522 (-4.6A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 ( 4.4A)
ANP  A 522 ( 4.7A)
MG  A 521 ( 2.9A)
MG  A 521 ( 3.6A)
 0.77A 2fumB-3lijA:
28.5		 2fumB-3lijA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
QUE  A   1 (-2.9A)
 0.81A 2fumB-3lm5A:
27.6		 2fumB-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  49
GLY A  50
VAL A  57
ALA A  70
MET A 120
TYR A 122
VAL A 123
LYS A 168
ASN A 171
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.2A)
None
None
None
 0.71A 2fumB-3mvjA:
26.6		 2fumB-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
GLY A  89
VAL A  96
ALA A 109
TYR A 161
LYS A 207
ASN A 210
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
None
 0.65A 2fumB-3nuuA:
28.3		 2fumB-3nuuA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 LEU A 348
GLY A 349
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.3A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 (-4.0A)
 0.77A 2fumB-3pfqA:
24.4		 2fumB-3pfqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		10 LEU A 348
VAL A 356
ALA A 369
MET A 420
TYR A 422
VAL A 423
LYS A 468
ASN A 471
MET A 473
ASP A 484
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-4.8A)
ANP  A 800 (-4.2A)
ANP  A 800 (-4.0A)
None
ANP  A 800 ( 4.5A)
ANP  A 800 ( 4.6A)
ANP  A 800 (-3.0A)
 0.83A 2fumB-3pfqA:
24.4		 2fumB-3pfqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
VAL A 565
ALA A 576
TYR A 627
LYS A 678
ASN A 681
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.5A)
 0.88A 2fumB-3ppzA:
27.1		 2fumB-3ppzA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  50
GLY A  51
VAL A  58
ALA A  71
MET A 118
LYS A 168
ASN A 171
ASP A 187
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
None
I85  A 350 (-4.4A)
I85  A 350 (-3.3A)
 0.65A 2fumB-3sheA:
22.3		 2fumB-3sheA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
GLY A 362
VAL A 369
ALA A 382
MET A 433
VAL A 436
LYS A 481
ASN A 484
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
None
None
 0.70A 2fumB-3txoA:
23.8		 2fumB-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
VAL A 369
ALA A 382
MET A 433
VAL A 436
LYS A 481
ASN A 484
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
None
None
07U  A   1 (-3.6A)
 0.77A 2fumB-3txoA:
23.8		 2fumB-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
LYS A 418
ASN A 421
 None
None
None
None
None
TPO  A 455 ( 2.9A)
None
 0.98A 2fumB-3ulzA:
22.0		 2fumB-3ulzA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
GLY A 140
VAL A 147
ALA A 160
TYR A 212
LYS A 258
ASN A 261
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
None
None
 0.73A 2fumB-3w18A:
25.1		 2fumB-3w18A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
VAL A  83
ALA A  96
MET A 144
LYS A 193
ASN A 196
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
 0.99A 2fumB-3wigA:
25.7		 2fumB-3wigA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
ALA A 104
MET A 154
LYS A 203
ASN A 206
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
None
None
None
 0.89A 2fumB-4aw2A:
24.4		 2fumB-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
ASN A 206
ASP A 219
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
None
None
 0.64A 2fumB-4aw2A:
24.4		 2fumB-4aw2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		10 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LYS A 141
ASN A 144
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.5A)
STU  A1550 (-3.8A)
None
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.95A 2fumB-4cfhA:
29.0		 2fumB-4cfhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
MET A 737
TYR A 739
LYS A 784
ASN A 787
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 ( 3.8A)
MG  A1986 ( 3.2A)
AGS  A1985 ( 3.3A)
 0.69A 2fumB-4crsA:
26.1		 2fumB-4crsA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		8 LEU A  16
VAL A  24
ALA A  37
MET A  87
TYR A  89
LYS A 135
ASN A 138
ASP A 151
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.6A)
ANP  A 300 (-4.3A)
None
None
None
 1.09A 2fumB-4eqmA:
30.3		 2fumB-4eqmA:
40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
ASN A 140
MET A 142
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.9A)
BX7  A 401 ( 3.7A)
 0.76A 2fumB-4eutA:
13.9		 2fumB-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
ASN A 140
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.5A)
None
BX7  A 401 ( 3.7A)
 0.61A 2fumB-4eutA:
13.9		 2fumB-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
LYS A 137
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.7A)
None
BX7  A 401 (-3.6A)
 0.84A 2fumB-4euuA:
25.8		 2fumB-4euuA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  65
VAL A  72
ALA A  88
MET A 134
LYS A 179
ASN A 182
ASP A 196
 ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 ( 3.9A)
None
MG  A 602 ( 2.6A)
MG  A 602 ( 3.1A)
 0.81A 2fumB-4f99A:
17.4		 2fumB-4f99A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  65
VAL A  72
ALA A  88
MET A 134
TYR A 136
ASN A 182
ASP A 196
 ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 ( 3.9A)
ADP  A 601 (-4.1A)
MG  A 602 ( 2.6A)
MG  A 602 ( 3.1A)
 0.73A 2fumB-4f99A:
17.4		 2fumB-4f99A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  26
GLY A  27
VAL A  34
ALA A  47
MET A  95
VAL A  98
LYS A 143
ASN A 146
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-3.9A)
None
ATP  A 401 (-3.4A)
 0.71A 2fumB-4fg8A:
25.2		 2fumB-4fg8A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
GLY A 856
VAL A 863
ALA A 880
MET A 929
TYR A 931
ASN A 981
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
None
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.73A 2fumB-4gl9A:
25.9		 2fumB-4gl9A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 156
GLY A 157
VAL A 164
ALA A 177
MET A 227
TYR A 229
LYS A 276
ASN A 279
ASP A 292
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 ( 4.4A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 ( 3.4A)
 0.75A 2fumB-4gv1A:
26.7		 2fumB-4gv1A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 156
GLY A 157
VAL A 164
ALA A 177
MET A 227
TYR A 229
LYS A 276
ASN A 279
MET A 281
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 ( 4.4A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 (-3.5A)
 0.82A 2fumB-4gv1A:
26.7		 2fumB-4gv1A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
GLY A 829
VAL A 836
ALA A 853
MET A 902
TYR A 904
ASN A 954
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
None
19S  A1201 ( 4.1A)
 0.52A 2fumB-4hviA:
26.6		 2fumB-4hviA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 407
VAL A 414
ALA A 427
MET A 469
LYS A 517
ASN A 520
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
 0.81A 2fumB-4idtA:
26.7		 2fumB-4idtA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
LYS A 137
ASN A 140
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.4A)
None
None
 1.00A 2fumB-4jlcA:
20.8		 2fumB-4jlcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 GLY A  47
VAL A  54
TYR A 154
VAL A 155
LYS A 197
ASN A 200
MET A 202
 GNP  A 401 (-3.6A)
GNP  A 401 (-4.2A)
GNP  A 401 ( 4.5A)
GNP  A 401 (-4.0A)
GNP  A 401 (-3.4A)
MG  A 402 ( 2.6A)
GNP  A 401 (-3.6A)
 0.81A 2fumB-4jr7A:
23.4		 2fumB-4jr7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A  54
TYR A 154
VAL A 155
LYS A 197
ASN A 200
MET A 202
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 ( 4.5A)
GNP  A 401 (-4.0A)
GNP  A 401 (-3.4A)
MG  A 402 ( 2.6A)
GNP  A 401 (-3.6A)
GNP  A 401 ( 2.7A)
 0.92A 2fumB-4jr7A:
23.4		 2fumB-4jr7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A  43
VAL A  50
ALA A  61
MET A 104
TYR A 106
LYS A 158
ASN A 161
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
None
None
1UL  A 501 (-4.2A)
 0.84A 2fumB-4l52A:
19.5		 2fumB-4l52A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU E  45
GLY E  46
VAL E  53
VAL E 116
LYS E 158
ASN E 161
MET E 163
 None
 0.76A 2fumB-4md8E:
16.5		 2fumB-4md8E:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU E  45
VAL E  53
VAL E 116
LYS E 158
ASN E 161
MET E 163
ASP E 175
 None
 0.79A 2fumB-4md8E:
16.5		 2fumB-4md8E:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
VAL B  38
ALA B  51
MET B  99
TYR B 101
LYS B 146
ASN B 149
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
None
MN  B 501 ( 3.1A)
 0.81A 2fumB-4o27B:
21.0		 2fumB-4o27B:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.6A)
 0.62A 2fumB-4oliA:
24.9		 2fumB-4oliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 366
MET A 417
TYR A 419
VAL A 420
LYS A 465
ASN A 468
ASP A 481
 3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-2.9A)
 0.81A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 366
MET A 417
TYR A 419
VAL A 420
LYS A 465
ASN A 468
MET A 470
 3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.76A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 353
ALA A 366
TYR A 419
VAL A 420
LYS A 465
ASN A 468
ASP A 481
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-2.9A)
 0.78A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 353
ALA A 366
TYR A 419
VAL A 420
LYS A 465
ASN A 468
MET A 470
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.73A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
 None
 0.69A 2fumB-4redA:
21.8		 2fumB-4redA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		10 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
LYS A 143
ASN A 146
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.81A 2fumB-4rewA:
29.0		 2fumB-4rewA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		10 LEU A 104
GLY A 105
VAL A 112
ALA A 125
MET A 175
TYR A 177
VAL A 178
LYS A 223
ASN A 226
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
ZN  A 503 (-1.9A)
 0.73A 2fumB-4wb7A:
26.9		 2fumB-4wb7A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
MET A 264
LYS A 316
ASN A 319
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
None
None
 0.87A 2fumB-4wboA:
26.9		 2fumB-4wboA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
VAL A  60
ALA A  72
MET A 126
LYS A 178
ASN A 181
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
ZN  A 403 ( 4.3A)
KSA  A 405 (-4.0A)
ZN  A 403 ( 2.6A)
 0.87A 2fumB-4wsqA:
26.9		 2fumB-4wsqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		7 MET A 232
TYR A 234
VAL A 235
LYS A 278
ASN A 281
MET A 283
ASP A 293
 ADP  A 501 (-3.3A)
ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
MG  A 503 ( 4.8A)
MG  A 503 ( 2.9A)
ADP  A 501 ( 4.3A)
MG  A 504 (-2.3A)
 0.75A 2fumB-4y0xA:
22.9		 2fumB-4y0xA:
28.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
LYS A 140
ASN A 143
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
None
GOL  A 404 ( 4.6A)
 0.71A 2fumB-5ci7A:
27.5		 2fumB-5ci7A:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 ( 4.9A)
 0.55A 2fumB-5f1zA:
26.3		 2fumB-5f1zA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  93
LYS A 138
ASN A 141
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-4.0A)
TPO  B 787 ( 2.7A)
MG  A 302 ( 2.8A)
 0.52A 2fumB-5hu3A:
30.4		 2fumB-5hu3A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
VAL A  65
ALA A  77
MET A 130
TYR A 132
ASN A 185
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
 0.82A 2fumB-5i3oA:
25.7		 2fumB-5i3oA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		10 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LYS A 141
ASN A 144
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.5A)
 0.77A 2fumB-5isoA:
28.5		 2fumB-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  43
MET A  90
LYS A 138
ASN A 141
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
None
None
6G2  A 901 (-3.4A)
 0.87A 2fumB-5j5tA:
25.3		 2fumB-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 404
ALA A 417
MET A 465
VAL A 468
LYS A 513
ASN A 516
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.0A)
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2fumB-5jznA:
27.4		 2fumB-5jznA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  49
ALA A  60
MET A 110
TYR A 112
LYS A 158
ASN A 161
ASP A 174
 None
STU  A 901 (-3.3A)
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
None
STU  A 901 ( 4.8A)
STU  A 901 (-4.1A)
 0.68A 2fumB-5lohA:
21.1		 2fumB-5lohA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
MET A 169
TYR A 171
LYS A 216
ASN A 219
ASP A 232
 None
 0.66A 2fumB-5u7qA:
23.5		 2fumB-5u7qA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
TYR A  94
VAL A  95
LYS A 140
ASN A 143
MET A 145
MET A 155
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
G93  A 301 ( 4.3A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.2A)
 0.57A 2fumB-5u94A:
40.7		 2fumB-5u94A:
84.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 9 LEU A 686
GLY A 687
VAL A 694
ALA A 707
MET A 754
VAL A 757
LYS A 805
ASN A 808
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-3.9A)
None
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.6A)
 0.65A 2fumB-5vilA:
28.9		 2fumB-5vilA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
GLY A  34
VAL A  41
ALA A  54
MET A  99
TYR A 101
LYS A 148
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.5A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-3.1A)
 1.08A 2fumB-6ao5A:
18.7		 2fumB-6ao5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
VAL A  41
ALA A  54
TYR A 101
LYS A 148
ASN A 151
ASP A 164
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-3.1A)
ANP  A 501 ( 2.6A)
MG  A 502 ( 3.1A)
 1.08A 2fumB-6ao5A:
18.7		 2fumB-6ao5A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 7 VAL A  27
ALA A  40
MET A  95
VAL A  98
LYS A 143
ASN A 146
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.6A)
CJJ  A 301 (-3.5A)
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.3A)
 0.70A 2fumB-6b2qA:
35.6		 2fumB-6b2qA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
 0.66A 2fumB-6bx6A:
22.4		 2fumB-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
GLY A 367
VAL A 374
ALA A 388
MET A 438
LYS A 486
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
EE4  A 701 ( 3.8A)
None
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.48A 2fumB-6c0tA:
20.0		 2fumB-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 GLY A  67
VAL A  74
ALA A  87
MET A 136
TYR A 138
LYS A 184
ASN A 187
ASP A 200
 None
 0.79A 2fumB-6c9dA:
27.0		 2fumB-6c9dA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 GLY A 172
VAL A 179
ALA A 192
VAL A 270
LYS A 314
ASN A 317
ASP A 330
 F6J  A 501 ( 3.9A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-4.0A)
None
F6J  A 501 ( 4.7A)
F6J  A 501 (-3.8A)
 0.68A 2fumB-6cmjA:
28.2		 2fumB-6cmjA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 7 LEU A 275
GLY A 276
VAL A 283
ALA A 296
LYS A 395
ASN A 398
MET A 400
 FE7  A 601 (-3.8A)
FE7  A 601 ( 3.7A)
FE7  A 601 ( 4.3A)
FE7  A 601 (-3.3A)
MG  A 602 ( 4.8A)
MG  A 602 ( 4.4A)
FE7  A 601 (-3.8A)
 0.92A 2fumB-6cthA:
15.5		 2fumB-6cthA:
14.48