SIMILAR PATTERNS OF AMINO ACIDS FOR 2FT9_A_CHDA130

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 PHE A 247
VAL A 162
ILE A  63
SER A  39
ILE A  64
None
1.10A 2ft9A-1ciyA:
0.0
2ft9A-1ciyA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34


(Pisum sativum)
PF04548
(AIG1)
5 VAL A 141
ILE A 120
ILE A 153
VAL A 252
LEU A 108
None
1.27A 2ft9A-1h65A:
0.0
2ft9A-1h65A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger)
PF01670
(Glyco_hydro_12)
5 PHE A  68
VAL A  66
PHE A 163
ILE A 119
LEU A 196
None
1.06A 2ft9A-1ks5A:
undetectable
2ft9A-1ks5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL F 121
ASN F 162
ILE F 205
ILE F 225
VAL F 193
None
1.16A 2ft9A-1nfdF:
0.4
2ft9A-1nfdF:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1u GASTROTROPIN

(Homo sapiens)
PF14651
(Lipocalin_7)
5 PHE A  17
ASN A  61
PHE A  63
ILE A  71
VAL A  83
None
1.01A 2ft9A-1o1uA:
17.6
2ft9A-1o1uA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER


(Rhinella
arenarum)
PF14651
(Lipocalin_7)
6 PHE A  17
VAL A  21
ASN A  60
PHE A  62
ILE A  70
HIS A  98
None
0.96A 2ft9A-1p6pA:
20.6
2ft9A-1p6pA:
73.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE


(Escherichia
coli)
PF01979
(Amidohydro_1)
5 ASN A 232
PHE A 238
ILE A 253
SER A 255
LEU A 317
None
1.12A 2ft9A-1pojA:
0.2
2ft9A-1pojA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum)
PF00067
(p450)
5 VAL A 106
PHE A 172
ILE A 252
ILE A 251
LEU A 244
None
None
None
HEM  A 440 (-4.5A)
None
1.26A 2ft9A-1q5dA:
undetectable
2ft9A-1q5dA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1


(Caenorhabditis
elegans)
PF00248
(Aldo_ket_red)
5 PHE A 312
PHE A 138
SER A 174
ILE A 160
VAL A 134
None
1.21A 2ft9A-1qwkA:
undetectable
2ft9A-1qwkA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq4 INTERFERON-INDUCIBLE
GTPASE


(Mus musculus)
PF05049
(IIGP)
5 PHE A 124
VAL A  72
ILE A 248
VAL A 270
LEU A  89
None
1.17A 2ft9A-1tq4A:
undetectable
2ft9A-1tq4A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8)
5 ASN A 677
ILE A 655
ILE A 631
VAL A 658
LEU A 648
None
1.20A 2ft9A-1w8aA:
undetectable
2ft9A-1w8aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ


(Bacillus
subtilis)
PF12697
(Abhydrolase_6)
5 PHE A  50
CYH A  82
VAL A  78
PHE A 113
LEU A 116
None
1.23A 2ft9A-1womA:
undetectable
2ft9A-1womA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens)
PF08609
(Fes1)
5 PHE A 226
VAL A 216
PHE A 288
VAL A 292
LEU A 235
None
1.20A 2ft9A-1xqsA:
undetectable
2ft9A-1xqsA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)


(Geobacillus
stearothermophilus)
PF00121
(TIM)
5 VAL A  77
ASN A   8
ILE A  91
VAL A  38
LEU A  46
None
PGA  A 301 (-4.6A)
None
None
None
1.28A 2ft9A-2btmA:
undetectable
2ft9A-2btmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE


(Arabidopsis
thaliana)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A  76
ASN A 354
ILE A  41
VAL A  66
LEU A  29
None
1.15A 2ft9A-2cf5A:
undetectable
2ft9A-2cf5A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8b PROBABLE
MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A


(Aquifex
aeolicus)
PF12804
(NTP_transf_3)
5 PHE A 101
VAL A 118
ASN A 184
VAL A  42
LEU A 103
None
1.17A 2ft9A-2e8bA:
undetectable
2ft9A-2e8bA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00202
(Aminotran_3)
5 VAL A 254
ASN A  81
SER A 110
ILE A 290
CYH A 317
PLP  A1001 ( 4.3A)
None
None
None
None
1.19A 2ft9A-2eo5A:
undetectable
2ft9A-2eo5A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE


(Homo sapiens)
PF01612
(DNA_pol_A_exo1)
5 VAL A 133
PHE A 151
ILE A 153
VAL A  97
LEU A 102
None
1.25A 2ft9A-2fbvA:
undetectable
2ft9A-2fbvA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER


(Ambystoma
mexicanum)
PF14651
(Lipocalin_7)
7 ASN A  60
PHE A  62
ILE A  70
SER A  72
ILE A  78
CYH A  80
VAL A  82
None
None
None
OLA  A 130 ( 3.8A)
None
None
None
0.93A 2ft9A-2ftbA:
23.0
2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER


(Ambystoma
mexicanum)
PF14651
(Lipocalin_7)
10 PHE A  17
VAL A  21
ASN A  60
PHE A  62
ILE A  70
CYH A  80
VAL A  82
PHE A  96
HIS A  98
LEU A 111
None
OLA  A 130 ( 4.9A)
None
None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
0.61A 2ft9A-2ftbA:
23.0
2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER


(Ambystoma
mexicanum)
PF14651
(Lipocalin_7)
10 PHE A  17
VAL A  21
ASN A  60
PHE A  62
ILE A  70
ILE A  78
CYH A  80
VAL A  82
PHE A  96
HIS A  98
None
OLA  A 130 ( 4.9A)
None
None
None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
0.59A 2ft9A-2ftbA:
23.0
2ft9A-2ftbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER


(Ambystoma
mexicanum)
PF14651
(Lipocalin_7)
6 VAL A 113
ASN A  60
PHE A  62
ILE A  70
SER A  72
ILE A  78
None
None
None
None
OLA  A 130 ( 3.8A)
None
1.17A 2ft9A-2ftbA:
23.0
2ft9A-2ftbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT


(Vaccinia virus)
PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N)
5 PHE D  52
VAL D  56
ASN D 228
ILE D 229
LEU D 104
None
1.28A 2ft9A-2gafD:
undetectable
2ft9A-2gafD:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jty TYPE-1 FIMBRIAL
PROTEIN, A CHAIN


(Escherichia
coli)
PF00419
(Fimbrial)
5 PHE A 177
VAL A  32
ILE A 131
ILE A  56
PHE A 154
None
1.26A 2ft9A-2jtyA:
undetectable
2ft9A-2jtyA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus)
PF14651
(Lipocalin_7)
5 ASN A  61
PHE A  63
VAL A  83
PHE A  94
HIS A  99
CHO  A 201 ( 3.5A)
CHO  A 201 (-3.1A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-2.9A)
CHO  A 201 (-3.0A)
0.96A 2ft9A-2lbaA:
18.8
2ft9A-2lbaA:
38.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus)
PF14651
(Lipocalin_7)
5 PHE A  17
ASN A  61
PHE A  63
VAL A  83
HIS A  99
CHO  A 200 ( 4.3A)
CHO  A 201 ( 3.5A)
CHO  A 201 (-3.1A)
CHO  A 201 ( 4.0A)
CHO  A 201 (-3.0A)
0.72A 2ft9A-2lbaA:
18.8
2ft9A-2lbaA:
38.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM


(Homo sapiens)
PF02985
(HEAT)
PF13646
(HEAT_2)
5 ILE A 326
ILE A 322
CYH A 310
VAL A 306
LEU A 365
None
1.05A 2ft9A-2pkgA:
undetectable
2ft9A-2pkgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzz UPF0201 PROTEIN
MJ1564


(Methanocaldococcus
jannaschii)
PF01877
(RNA_binding)
5 PHE A  27
VAL A   4
ILE A 120
ILE A 119
LEU A  54
None
1.25A 2ft9A-2pzzA:
undetectable
2ft9A-2pzzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgu PROBABLE SIGNAL
PEPTIDE PROTEIN


(Ralstonia
solanacearum)
PF05494
(MlaC)
5 VAL A  64
ILE A 168
ILE A 166
VAL A 148
LEU A 113
PEF  A 301 ( 4.8A)
PEF  A 301 (-4.3A)
PEF  A 301 ( 4.0A)
None
None
1.08A 2ft9A-2qguA:
undetectable
2ft9A-2qguA:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN


(Danio rerio)
PF14651
(Lipocalin_7)
7 PHE A  17
ASN A  60
PHE A  62
ILE A  70
VAL A  82
HIS A  98
LEU A 111
None
IPA  A 141 ( 4.7A)
IPA  A 142 ( 4.4A)
IPA  A 141 ( 4.5A)
None
IPA  A 140 (-3.7A)
CHD  A 130 ( 4.9A)
1.05A 2ft9A-2qo4A:
20.7
2ft9A-2qo4A:
69.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xcz POSSIBLE ATLS1-LIKE
LIGHT-INDUCIBLE
PROTEIN


(Prochlorococcus
marinus)
PF01187
(MIF)
5 ILE A  94
ILE A  89
CYH A  57
VAL A  59
LEU A  18
None
1.08A 2ft9A-2xczA:
undetectable
2ft9A-2xczA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfv REGULATORY PROTEIN
SWI6


(Saccharomyces
cerevisiae)
no annotation 5 PHE A  55
ILE A  82
CYH A  87
PHE A  34
HIS A  33
None
1.28A 2ft9A-2xfvA:
undetectable
2ft9A-2xfvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN


(Thermotoga
maritima)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
5 PHE A 207
VAL A  22
ILE A  60
VAL A 154
LEU A  34
None
1.20A 2ft9A-2yyzA:
undetectable
2ft9A-2yyzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN


(Campylobacter
jejuni)
PF02516
(STT3)
5 PHE A 709
PHE A 659
ILE A 637
ILE A 640
PHE A 687
None
None
None
MLY  A 641 ( 3.5A)
MLY  A 707 ( 4.4A)
1.28A 2ft9A-3aagA:
undetectable
2ft9A-3aagA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ega PROTEIN PELLINO
HOMOLOG 2


(Homo sapiens)
PF04710
(Pellino)
5 ILE A 246
SER A 244
ILE A 155
CYH A 141
VAL A 104
None
1.14A 2ft9A-3egaA:
undetectable
2ft9A-3egaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
5 PHE A1798
ASN A2494
ILE A2498
ILE A2501
LEU A1802
None
1.27A 2ft9A-3jbzA:
undetectable
2ft9A-3jbzA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
5 VAL A 447
PHE A 391
ILE A 415
ILE A 427
PHE A 501
None
1.24A 2ft9A-3kf3A:
undetectable
2ft9A-3kf3A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE


(Idiomarina
loihiensis)
PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat)
5 PHE A 226
ILE A 247
SER A 175
PHE A 222
HIS A 221
None
None
None
None
EDO  A 384 (-4.5A)
1.17A 2ft9A-3llxA:
undetectable
2ft9A-3llxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY


(Legionella
pneumophila)
PF00440
(TetR_N)
5 VAL A 138
ILE A 157
ILE A 156
PHE A  88
LEU A  70
None
1.29A 2ft9A-3on4A:
undetectable
2ft9A-3on4A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Homo sapiens)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
5 VAL A1298
PHE A1243
SER A1273
CYH A1226
VAL A1248
None
1.28A 2ft9A-3ptaA:
undetectable
2ft9A-3ptaA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT


(uncultured
archaeon)
PF02240
(MCR_gamma)
5 VAL C 138
ILE C 122
ILE C 123
HIS C  42
LEU C  40
None
1.29A 2ft9A-3sqgC:
undetectable
2ft9A-3sqgC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba)
PF12740
(Chlorophyllase2)
5 VAL A 220
ASN A 254
ILE A 257
ILE A 210
HIS A 168
None
1.02A 2ft9A-3visA:
undetectable
2ft9A-3visA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 PHE A2701
VAL A2759
ILE A2786
CYH A2718
LEU A2699
None
1.22A 2ft9A-3vkgA:
undetectable
2ft9A-3vkgA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF01786
(AOX)
5 VAL A 242
ILE A 259
ILE A 262
VAL A 115
PHE A 169
None
1.28A 2ft9A-3vvaA:
undetectable
2ft9A-3vvaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4


(Mus musculus)
PF00225
(Kinesin)
5 PHE A  65
VAL A 114
PHE A 134
ILE A 221
ILE A 219
None
1.10A 2ft9A-3zfcA:
undetectable
2ft9A-3zfcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4


(Homo sapiens)
PF07679
(I-set)
PF13855
(LRR_8)
5 PHE A 230
ILE A 257
VAL A 249
PHE A 262
LEU A 265
None
1.28A 2ft9A-3zyiA:
undetectable
2ft9A-3zyiA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
5 PHE A 474
ILE A 565
SER A 561
VAL A 575
PHE A 556
None
1.19A 2ft9A-4a01A:
undetectable
2ft9A-4a01A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
5 PHE A 192
VAL A 103
ILE A 290
HIS A 284
LEU A 263
None
1.18A 2ft9A-4aguA:
undetectable
2ft9A-4aguA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ang COAT PROTEIN

(Pseudomonas
phage PRR1)
PF01819
(Levi_coat)
5 PHE A  91
ILE A  47
VAL A  89
PHE A  45
LEU A   8
None
1.21A 2ft9A-4angA:
3.6
2ft9A-4angA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 PHE A 247
VAL A 162
ILE A  63
SER A  39
ILE A  64
None
1.11A 2ft9A-4arxA:
undetectable
2ft9A-4arxA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15


(Homo sapiens)
PF00225
(Kinesin)
5 PHE A  72
PHE A 146
ILE A 230
ILE A 228
CYH A 148
None
1.09A 2ft9A-4bn2A:
undetectable
2ft9A-4bn2A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca)
PF12740
(Chlorophyllase2)
5 VAL A 181
ASN A 215
ILE A 218
ILE A 171
HIS A 129
None
1.02A 2ft9A-4cg1A:
undetectable
2ft9A-4cg1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs5 PROLIFERATING CELL
NUCLEAR ANTIGEN


(Litopenaeus
vannamei)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 PHE A 144
VAL A 225
VAL A  45
PHE A 215
LEU A 212
None
1.28A 2ft9A-4cs5A:
undetectable
2ft9A-4cs5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga)
PF00704
(Glyco_hydro_18)
5 PHE A 303
ILE A 238
ILE A 203
PHE A 314
LEU A 372
None
1.03A 2ft9A-4dwsA:
undetectable
2ft9A-4dwsA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9o IMV MEMBRANE PROTEIN

(Vaccinia virus)
PF00194
(Carb_anhydrase)
5 PHE X 185
ILE X 119
ILE X  91
HIS X  95
LEU X  63
None
1.23A 2ft9A-4e9oX:
1.8
2ft9A-4e9oX:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN


(Drosophila
melanogaster)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 PHE A 144
VAL A 225
VAL A  45
PHE A 215
LEU A 212
None
1.26A 2ft9A-4hk1A:
undetectable
2ft9A-4hk1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6v AMIDOHYDROLASE 2

(Planctopirus
limnophila)
PF02614
(UxaC)
5 VAL A 337
PHE A 169
VAL A 168
PHE A 271
LEU A 305
None
GOL  A 502 (-4.4A)
None
None
None
1.22A 2ft9A-4i6vA:
undetectable
2ft9A-4i6vA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis)
PF11175
(DUF2961)
5 ILE A 121
SER A 135
ILE A 137
PHE A 141
LEU A 156
None
1.11A 2ft9A-4kq7A:
undetectable
2ft9A-4kq7A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le4 BETA-GLUCANASE

(Podospora
anserina)
no annotation 5 PHE A 196
SER A 147
ILE A 135
VAL A 183
HIS A 181
None
0.99A 2ft9A-4le4A:
undetectable
2ft9A-4le4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmo TELOMERASE REVERSE
TRANSCRIPTASE


(Takifugu
rubripes)
PF12009
(Telomerase_RBD)
5 VAL A 337
ILE A 424
PHE A 502
HIS A 373
LEU A 315
None
1.24A 2ft9A-4lmoA:
undetectable
2ft9A-4lmoA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyy HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE


(Shewanella
pealeana)
PF00156
(Pribosyltran)
5 VAL A  46
PHE A 151
ILE A 152
ILE A 169
VAL A 172
None
1.20A 2ft9A-4lyyA:
undetectable
2ft9A-4lyyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ


(Streptomyces
hygroscopicus)
PF13649
(Methyltransf_25)
5 PHE A 230
VAL A 224
ILE A 195
VAL A 202
LEU A 186
None
IOD  A 411 ( 4.8A)
None
None
None
1.25A 2ft9A-4m73A:
undetectable
2ft9A-4m73A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC


(Arabidopsis
thaliana)
PF00121
(TIM)
5 VAL A  79
ASN A  10
ILE A  93
VAL A  41
LEU A  49
None
1.25A 2ft9A-4obtA:
undetectable
2ft9A-4obtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00121
(TIM)
5 PHE A 242
VAL A  40
ILE A  93
ILE A 125
CYH A 127
None
1.28A 2ft9A-4ohqA:
undetectable
2ft9A-4ohqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN


(Escherichia
coli)
no annotation 5 VAL B 333
ILE B 277
ILE B 306
CYH B 304
PHE B 339
None
1.16A 2ft9A-4pl2B:
undetectable
2ft9A-4pl2B:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 PHE A 247
VAL A 162
ILE A  63
SER A  39
ILE A  64
None
1.23A 2ft9A-4w8jA:
undetectable
2ft9A-4w8jA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wer DIACYLGLYCEROL
KINASE CATALYTIC
DOMAIN PROTEIN


(Enterococcus
faecalis)
PF00781
(DAGK_cat)
5 ASN A 128
ILE A 281
ILE A 259
VAL A 271
LEU A 218
None
1.15A 2ft9A-4werA:
undetectable
2ft9A-4werA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis)
PF03403
(PAF-AH_p_II)
5 VAL A 227
ASN A 261
ILE A 264
ILE A 217
HIS A 175
None
1.09A 2ft9A-4wfiA:
undetectable
2ft9A-4wfiA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT


(Pseudomonas
mendocina)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 PHE A 103
VAL A 128
PHE A 118
VAL A 163
LEU A 185
None
None
None
FAD  A 402 (-3.3A)
None
1.15A 2ft9A-4wqmA:
undetectable
2ft9A-4wqmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE


(Clostridium
acetobutylicum)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 VAL A 241
ASN A 316
ILE A 344
VAL A 337
PHE A 178
None
1.14A 2ft9A-4wyrA:
undetectable
2ft9A-4wyrA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1v CD2-ASSOCIATED
PROTEIN


(Homo sapiens)
PF14604
(SH3_9)
5 VAL A 141
ILE A 135
ILE A 137
CYH A 113
VAL A 115
None
1.23A 2ft9A-4x1vA:
undetectable
2ft9A-4x1vA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT


(Escherichia
coli)
PF01555
(N6_N4_Mtase)
5 PHE A  29
ILE A  44
ILE A  43
PHE A  25
LEU A  21
None
1.12A 2ft9A-4zcfA:
undetectable
2ft9A-4zcfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
5 VAL A 149
ILE A 161
CYH A 144
VAL A 139
PHE A 146
None
1.25A 2ft9A-5a0tA:
undetectable
2ft9A-5a0tA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR


(Drosophila
melanogaster)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind)
5 PHE A1077
VAL A1143
ILE A1129
CYH A 980
LEU A1003
None
1.18A 2ft9A-5aorA:
undetectable
2ft9A-5aorA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT


(Squalus
acanthias)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
5 ILE A 373
SER A 375
CYH A 606
VAL A 762
LEU A 750
None
1.23A 2ft9A-5aw4A:
2.6
2ft9A-5aw4A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
5 PHE A1003
PHE A 802
ILE A 830
VAL A 806
PHE A 926
None
1.21A 2ft9A-5cslA:
undetectable
2ft9A-5cslA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco GLUTATHIONE
S-TRANSFERASE U20


(Arabidopsis
thaliana)
PF02798
(GST_N)
PF13410
(GST_C_2)
5 PHE B 145
ILE B 175
SER B 179
ILE B 183
LEU B 157
None
1.04A 2ft9A-5ecoB:
undetectable
2ft9A-5ecoB:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61


(Saccharomyces
cerevisiae)
PF08704
(GCD14)
5 PHE B  39
ILE B  51
SER B  58
ILE B  13
VAL B  31
None
1.17A 2ft9A-5ergB:
undetectable
2ft9A-5ergB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus)
PF07245
(Phlebovirus_G2)
5 PHE A 607
VAL A 760
ILE A 734
VAL A 597
LEU A 605
None
1.24A 2ft9A-5g47A:
undetectable
2ft9A-5g47A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 PHE B 237
ASN B 183
PHE B 158
ILE B 206
LEU B 213
None
1.18A 2ft9A-5gqrB:
undetectable
2ft9A-5gqrB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B


(Homo sapiens)
no annotation 5 ILE A1076
SER A1078
ILE A1075
VAL A1044
LEU A1112
None
1.05A 2ft9A-5hdtA:
undetectable
2ft9A-5hdtA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE


(Geobacillus
stearothermophilus)
PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C)
5 VAL A 438
ILE A 508
ILE A 506
VAL A 480
PHE A 532
None
1.20A 2ft9A-5hp6A:
undetectable
2ft9A-5hp6A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
5 PHE A 106
VAL A 104
ILE A  44
ILE A  31
LEU A  57
None
1.28A 2ft9A-5hqbA:
2.4
2ft9A-5hqbA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
5 PHE A 106
VAL A 104
ILE A  44
PHE A 129
LEU A  57
None
1.19A 2ft9A-5hqbA:
2.4
2ft9A-5hqbA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli)
PF04055
(Radical_SAM)
5 VAL A 333
ILE A 277
ILE A 306
CYH A 304
PHE A 339
None
1.15A 2ft9A-5hr6A:
undetectable
2ft9A-5hr6A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibx TRIOSEPHOSPHATE
ISOMERASE


(Streptococcus
pneumoniae)
PF00121
(TIM)
5 ILE A 165
SER A 163
ILE A 126
CYH A 128
VAL A 144
None
1.25A 2ft9A-5ibxA:
undetectable
2ft9A-5ibxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw9 BASEPLATE WEDGE
PROTEIN GP25


(Escherichia
virus T4)
PF04965
(GPW_gp25)
5 ILE A  40
SER A  35
ILE A  39
CYH A  55
LEU A  91
None
1.29A 2ft9A-5iw9A:
undetectable
2ft9A-5iw9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)
TOXR-ACTIVATED GENE
(TAGE)


(Helicobacter
pylori;
Helicobacter
pylori)
PF01551
(Peptidase_M23)
PF01551
(Peptidase_M23)
5 PHE B 207
VAL B 289
ASN A 141
PHE A 267
VAL A 255
None
1.17A 2ft9A-5j1lB:
undetectable
2ft9A-5j1lB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 ILE A 445
CYH A 448
VAL A 451
PHE A 425
LEU A 401
None
1.02A 2ft9A-5jbgA:
undetectable
2ft9A-5jbgA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT


(Aromatoleum
aromaticum)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
5 VAL b  75
SER b 243
ILE b 247
VAL b 303
LEU b 108
None
1.11A 2ft9A-5l9wb:
undetectable
2ft9A-5l9wb:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus)
no annotation 5 PHE A 413
ILE A 441
ILE A 433
VAL A 351
HIS A 353
None
1.27A 2ft9A-5n4lA:
undetectable
2ft9A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th3 R-SWAI PROTEIN

(Staphylococcus
warneri)
no annotation 5 PHE A  81
ILE A  90
ILE A  92
CYH A  79
PHE A  48
None
1.22A 2ft9A-5th3A:
undetectable
2ft9A-5th3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE


(Pseudomonas
aeruginosa)
PF03331
(LpxC)
5 PHE A 181
VAL A 111
ILE A 102
HIS A 237
LEU A 240
None
None
None
ZN  A 501 ( 3.2A)
None
1.28A 2ft9A-5u39A:
undetectable
2ft9A-5u39A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usl IMV MEMBRANE PROTEIN

(Vaccinia virus)
no annotation 5 PHE X 185
ILE X 119
ILE X  91
HIS X  95
LEU X  63
None
1.20A 2ft9A-5uslX:
1.9
2ft9A-5uslX:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR


(Danio rerio)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R)
5 PHE A1233
ILE A1211
ILE A1270
VAL A1213
LEU A1259
None
1.29A 2ft9A-5w81A:
undetectable
2ft9A-5w81A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydf PARAFIBROMIN

(Homo sapiens)
no annotation 5 PHE A  27
VAL A  25
ASN A  66
VAL A  86
LEU A   8
None
1.09A 2ft9A-5ydfA:
undetectable
2ft9A-5ydfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN


(Heartland virus)
no annotation 5 PHE A  45
VAL A 198
ILE A 172
VAL A  35
LEU A  43
None
1.21A 2ft9A-5yowA:
undetectable
2ft9A-5yowA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP


(Streptomyces
wadayamensis)
no annotation 5 ILE A 216
SER A  91
VAL A 214
PHE A 154
LEU A 122
None
LLP  A 221 ( 2.6A)
None
None
None
1.24A 2ft9A-6c9bA:
undetectable
2ft9A-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE


(Homo sapiens)
no annotation 5 PHE A 207
ILE A 225
ILE A 252
CYH A 250
LEU A 211
None
1.28A 2ft9A-6fcxA:
undetectable
2ft9A-6fcxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy8 -

(-)
no annotation 5 PHE A 359
VAL A 378
ILE A 133
ILE A 130
LEU A 174
None
1.16A 2ft9A-6gy8A:
undetectable
2ft9A-6gy8A:
undetectable