SIMILAR PATTERNS OF AMINO ACIDS FOR 2FR3_A_REAA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bih HEMOLIN

(Hyalophora
cecropia) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 LEU A 350
PRO A 315
THR A 390
VAL A 392
TYR A 311
 None
 1.05A 2fr3A-1bihA:
undetectable		 2fr3A-1bihA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		5 LEU D 262
ALA D 265
ALA D 269
THR D 279
LEU D 308
 None
 1.09A 2fr3A-1dkgD:
undetectable		 2fr3A-1dkgD:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		5 ILE A 499
ALA A 500
ALA A 486
THR A 490
VAL A 492
 None
FAD  A 522 (-3.3A)
None
None
None
 1.09A 2fr3A-1fl2A:
undetectable		 2fr3A-1fl2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		6 PHE B 384
ILE A 169
ALA A 349
ALA A 347
LEU A 248
TYR A 244
 None
 1.38A 2fr3A-1hleB:
undetectable		 2fr3A-1hleB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ILE A 676
PRO A 774
THR A 767
VAL A 756
LEU A 844
 None
 0.93A 2fr3A-1hwwA:
undetectable		 2fr3A-1hwwA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 PHE A 178
LEU A 285
ILE A 269
ALA A 268
ALA A 264
 None
 1.08A 2fr3A-1k4yA:
undetectable		 2fr3A-1k4yA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 ILE A 338
ALA A 312
THR A 343
VAL A 342
LEU A 307
 None
 1.05A 2fr3A-1kplA:
undetectable		 2fr3A-1kplA:
12.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		5 PHE A  16
ILE A  32
ALA A  33
THR A  53
LEU A 117
 None
 0.56A 2fr3A-1kqxA:
20.8		 2fr3A-1kqxA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 PHE A  78
ILE A  66
ALA A  67
ALA A  71
VAL A  27
 None
 0.92A 2fr3A-1kyiA:
undetectable		 2fr3A-1kyiA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ILE A  32
ALA A  33
THR A  53
LEU A 117
 None
 0.68A 2fr3A-1lpjA:
20.2		 2fr3A-1lpjA:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		5 LEU A1025
ILE A1008
ALA A1016
VAL A1138
LEU A1168
 None
 1.02A 2fr3A-1lurA:
undetectable		 2fr3A-1lurA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		5 LEU A 104
ILE A 118
ALA A 119
VAL A  29
LEU A  15
 None
 1.01A 2fr3A-1mivA:
undetectable		 2fr3A-1mivA:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		5 PHE A  16
LEU A  20
ILE A  32
ALA A  33
THR A  53
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.7A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.3A)
 0.87A 2fr3A-1mx8A:
16.5		 2fr3A-1mx8A:
44.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		6 PHE A  78
ILE A  66
ALA A  67
ALA A  71
VAL A  27
LEU A 103
 None
 1.28A 2fr3A-1ofhA:
undetectable		 2fr3A-1ofhA:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 2fr3A-1pmpA:
19.3		 2fr3A-1pmpA:
42.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 ILE A 194
ALA A 195
ALA A 199
PRO A 203
ARG A 206
 None
 1.05A 2fr3A-1pq4A:
undetectable		 2fr3A-1pq4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		5 LEU A  36
ILE A 232
ALA A 298
LEU A  44
ARG A  49
 None
 1.04A 2fr3A-1r76A:
undetectable		 2fr3A-1r76A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t57 CONSERVED PROTEIN
MTH1675

(Methanothermobacter
thermautotrophicus) 		PF02887
(PK_C) 		5 LEU A 175
ILE A 132
ALA A 133
ALA A 137
VAL A  36
 None
 1.01A 2fr3A-1t57A:
undetectable		 2fr3A-1t57A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 LEU A 135
ILE A  43
ALA A 119
ALA A 123
PRO A 127
 None
 0.96A 2fr3A-1x2bA:
undetectable		 2fr3A-1x2bA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrw PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A  74
ILE A  54
ALA A  28
PRO A  59
LEU A  66
 None
 1.08A 2fr3A-1yrwA:
undetectable		 2fr3A-1yrwA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT

(Pyrococcus
abyssi) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 LEU A 199
ILE A 194
ALA A 258
VAL A 186
LEU A 261
 None
 0.89A 2fr3A-1yz6A:
undetectable		 2fr3A-1yz6A:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		11 PHE A  15
LEU A  19
ALA A  32
ALA A  36
PRO A  39
THR A  54
THR A  56
VAL A  58
LEU A 120
ARG A 131
TYR A 133
 None
None
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.47A 2fr3A-2cbrA:
26.9		 2fr3A-2cbrA:
76.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
LEU A  19
ALA A  32
THR A  61
VAL A  58
 None
None
A80  A 201 ( 4.1A)
None
None
 0.99A 2fr3A-2cbrA:
26.9		 2fr3A-2cbrA:
76.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfe RIBONUCLEASE HII

(Thermococcus
kodakarensis) 		PF01351
(RNase_HII) 		5 PHE A 114
LEU A 118
ALA A 104
VAL A 141
LEU A  80
 None
 0.94A 2fr3A-2dfeA:
undetectable		 2fr3A-2dfeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 PHE A  23
LEU A  57
ILE A  77
ALA A  76
TYR A 100
 None
 0.84A 2fr3A-2i00A:
undetectable		 2fr3A-2i00A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 PHE A 180
LEU A 184
ILE A 150
ALA A 151
ALA A 155
 None
 1.07A 2fr3A-2ps3A:
undetectable		 2fr3A-2ps3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		5 PHE A 161
LEU A 211
THR A  23
VAL A  22
LEU A  87
 None
None
SO4  A 216 ( 3.2A)
None
None
 1.09A 2fr3A-2qsxA:
undetectable		 2fr3A-2qsxA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ILE A  32
ALA A  33
THR A  53
LEU A 117
 None
 0.59A 2fr3A-2rcqA:
19.2		 2fr3A-2rcqA:
36.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		5 LEU A 522
ILE A 525
ALA A 515
THR A 375
VAL A 562
 None
 1.10A 2fr3A-2vpjA:
undetectable		 2fr3A-2vpjA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 LEU A 752
ILE A 755
ALA A 669
THR A 742
VAL A 690
 None
 1.04A 2fr3A-2wl1A:
undetectable		 2fr3A-2wl1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 215
ILE A 212
ALA A 188
ALA A 124
VAL A 186
 None
 1.08A 2fr3A-2xecA:
undetectable		 2fr3A-2xecA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 PHE X  48
LEU X  52
THR X 305
VAL X 230
LEU X 280
 None
 1.01A 2fr3A-3b8aX:
undetectable		 2fr3A-3b8aX:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 PHE A 122
ILE A 219
THR A 112
THR A 141
VAL A 142
 None
 1.05A 2fr3A-3do5A:
undetectable		 2fr3A-3do5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		5 ILE A 280
ALA A 306
PRO A 308
THR A 292
LEU A 349
 None
 1.08A 2fr3A-3dohA:
undetectable		 2fr3A-3dohA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1t UNCHARACTERIZED
PROTEIN Q9I3C8_PSEAE

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 LEU A  17
THR A 116
THR A  71
VAL A  72
LEU A  86
 None
 1.09A 2fr3A-3f1tA:
2.0		 2fr3A-3f1tA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		5 ILE A 402
ALA A 405
THR A 433
LEU A  55
ARG A 425
 None
 1.00A 2fr3A-3fw6A:
undetectable		 2fr3A-3fw6A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 723
ALA B 722
PRO B 701
VAL B 987
TYR B 713
 None
 0.96A 2fr3A-3hkzB:
undetectable		 2fr3A-3hkzB:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		5 ILE A 249
ALA A 242
THR A 285
VAL A 284
TYR A  37
 None
 1.09A 2fr3A-3i1cA:
undetectable		 2fr3A-3i1cA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		5 LEU A 364
ILE A 314
ALA A 315
PRO A 323
VAL A 327
 None
 1.07A 2fr3A-3iuuA:
undetectable		 2fr3A-3iuuA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		5 PHE A 136
LEU A 140
ILE A 147
ALA A  25
ALA A  23
 None
 1.02A 2fr3A-3kzaA:
2.5		 2fr3A-3kzaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		5 PHE A 541
ALA A 539
ALA A 559
THR A 563
LEU A 281
 None
 0.98A 2fr3A-3loyA:
undetectable		 2fr3A-3loyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtx PROTEIN MD-1

(Gallus gallus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A 104
ILE A  73
ALA A  78
VAL A 147
LEU A 123
 None
None
PGT  A 300 ( 3.9A)
None
None
 1.06A 2fr3A-3mtxA:
undetectable		 2fr3A-3mtxA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwm PUTATIVE METAL
UPTAKE REGULATION
PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		5 PHE A  29
LEU A  67
ILE A 126
ALA A  96
VAL A  99
 None
 0.98A 2fr3A-3mwmA:
undetectable		 2fr3A-3mwmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 ILE A  20
ALA A  22
ALA A  63
THR A  84
LEU A 299
 None
 1.06A 2fr3A-3myoA:
undetectable		 2fr3A-3myoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Vibrio cholerae) 		PF00290
(Trp_syntA) 		5 ILE A 153
ALA A 154
ALA A 158
THR A 162
ARG A 199
 None
 1.07A 2fr3A-3navA:
undetectable		 2fr3A-3navA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.88A 2fr3A-3nr3A:
19.1		 2fr3A-3nr3A:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on2 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13305
(WHG) 		5 ILE A 167
ALA A 168
ALA A 172
VAL A 181
ARG A 105
 None
 1.04A 2fr3A-3on2A:
undetectable		 2fr3A-3on2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A 152
LEU A 156
ILE A 163
ALA A  41
ALA A  39
 None
 1.04A 2fr3A-3ph5A:
5.9		 2fr3A-3ph5A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 PHE A 157
LEU A  69
ILE A  72
ALA A  98
ALA A 125
 None
 1.04A 2fr3A-3qhaA:
undetectable		 2fr3A-3qhaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 ILE A 349
THR A 314
THR A 306
VAL A 305
ARG A  80
 None
None
None
PYR  A 702 ( 4.7A)
None
 1.03A 2fr3A-3r75A:
undetectable		 2fr3A-3r75A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A 312
LEU A 316
ALA A 284
ALA A 280
LEU A 112
 None
 0.98A 2fr3A-3s5sA:
undetectable		 2fr3A-3s5sA:
15.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 4.3A)
2AN  A 201 ( 4.0A)
None
2AN  A 201 ( 4.9A)
None
 0.77A 2fr3A-3wbgA:
19.2		 2fr3A-3wbgA:
41.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		5 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.06A 2fr3A-3wfoA:
undetectable		 2fr3A-3wfoA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo0 ALANINE-ANTICAPSIN
LIGASE BACD

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		5 PHE A 384
LEU A 379
ALA A 462
LEU A 397
TYR A 468
 None
 1.03A 2fr3A-3wo0A:
undetectable		 2fr3A-3wo0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		5 LEU A 182
ALA A 187
ALA A 191
THR A 137
TYR A 118
 None
 0.90A 2fr3A-3zjkA:
undetectable		 2fr3A-3zjkA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		5 LEU A 101
ALA A 149
THR A 217
THR A 221
TYR A 190
 None
 0.86A 2fr3A-3zxyA:
undetectable		 2fr3A-3zxyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		5 PHE A 266
LEU A 272
ALA A 276
ALA A 166
THR A 161
 None
NAG  A1324 (-3.9A)
None
None
None
 1.00A 2fr3A-4a5gA:
undetectable		 2fr3A-4a5gA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
 0.86A 2fr3A-4a60A:
18.0		 2fr3A-4a60A:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
ALA A  36
THR A  56
ARG A 129
TYR A 131
 None
 0.73A 2fr3A-4aznA:
18.7		 2fr3A-4aznA:
36.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 None
A9M  A1136 ( 4.7A)
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
 1.02A 2fr3A-4azpA:
19.6		 2fr3A-4azpA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 PHE A 174
LEU A 135
ALA A 148
ALA A 192
THR A 162
 None
 1.09A 2fr3A-4b18A:
undetectable		 2fr3A-4b18A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e13 DIKETOREDUCTASE

(Acinetobacter
baylyi) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 PHE A 144
LEU A 142
ILE A 182
ALA A 154
TYR A  54
 None
 1.10A 2fr3A-4e13A:
undetectable		 2fr3A-4e13A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A  32
ALA A  33
ALA A  37
VAL A 200
LEU A 259
 None
 1.02A 2fr3A-4e1lA:
undetectable		 2fr3A-4e1lA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		6 PHE A  42
LEU A 226
ALA A  40
PRO A 311
THR A 331
LEU A 325
 None
 1.02A 2fr3A-4gxtA:
undetectable		 2fr3A-4gxtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		5 LEU A 104
ALA A 152
THR A 220
THR A 224
TYR A 193
 None
 0.96A 2fr3A-4h6wA:
undetectable		 2fr3A-4h6wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 380
ALA A  53
ALA A  57
THR A 264
LEU A 235
 None
 1.10A 2fr3A-4hgvA:
undetectable		 2fr3A-4hgvA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 PHE A 404
LEU A 376
ALA A 820
ALA A 816
TYR A 809
 None
 1.00A 2fr3A-4hsuA:
undetectable		 2fr3A-4hsuA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 170
ILE A 211
ALA A 212
VAL A 241
LEU A 114
 None
 1.05A 2fr3A-4k17A:
undetectable		 2fr3A-4k17A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		5 PHE A 326
LEU A 239
ILE A 336
ALA A 341
LEU A 235
 None
 1.06A 2fr3A-4mnmA:
undetectable		 2fr3A-4mnmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ILE A 494
ALA A 437
ALA A 439
VAL A 468
LEU A 323
 None
 1.05A 2fr3A-4ogzA:
undetectable		 2fr3A-4ogzA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		5 ILE A 169
ALA A 168
ALA A 164
THR A 162
VAL A 146
 None
 1.02A 2fr3A-4rr5A:
undetectable		 2fr3A-4rr5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq5 PRENYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01040
(UbiA) 		5 PHE A 164
LEU A 168
ALA A 183
VAL A 237
LEU A  31
 None
 1.05A 2fr3A-4tq5A:
undetectable		 2fr3A-4tq5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		5 LEU A 269
ALA A 280
ALA A 284
VAL A 306
LEU A 255
 None
 1.07A 2fr3A-4tu3A:
undetectable		 2fr3A-4tu3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  81
ALA A  75
PRO A  15
THR A  16
LEU A  99
 None
 1.07A 2fr3A-4wr4A:
undetectable		 2fr3A-4wr4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		5 LEU A 109
ILE A  97
ALA A  98
VAL A 208
ARG A 142
 None
 0.99A 2fr3A-4xacA:
undetectable		 2fr3A-4xacA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		6 PHE A 383
ILE A 159
ALA A 345
ALA A 343
LEU A 241
TYR A 236
 None
 1.36A 2fr3A-4zk3A:
undetectable		 2fr3A-4zk3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 LEU A 337
ILE A 210
ALA A 207
THR A 290
TYR A 392
 None
 1.05A 2fr3A-5aqaA:
undetectable		 2fr3A-5aqaA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PRO A  38
THR A  53
LEU A 115
ARG A 126
TYR A 128
 PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.81A 2fr3A-5b29A:
19.3		 2fr3A-5b29A:
42.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 PHE A  17
PRO A  39
THR A  54
THR A  57
TYR A 129
 None
 1.05A 2fr3A-5bvqA:
18.1		 2fr3A-5bvqA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		5 PHE A  19
PRO A  41
THR A  56
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 4.8A)
None
PAM  A 201 ( 4.6A)
None
 0.77A 2fr3A-5bvtA:
18.9		 2fr3A-5bvtA:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 LEU A  30
ILE A 196
ALA A 197
ALA A  55
VAL A  86
 None
 1.03A 2fr3A-5cm5A:
undetectable		 2fr3A-5cm5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		5 LEU A 191
ILE A  61
ALA A  60
ALA A  56
TYR A  97
 None
 1.02A 2fr3A-5dk6A:
undetectable		 2fr3A-5dk6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 ALA A 162
ALA A 119
THR A  68
VAL A  96
TYR A 253
 None
 1.00A 2fr3A-5dmnA:
undetectable		 2fr3A-5dmnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 LEU A1296
ILE A1230
ALA A1180
VAL A1242
LEU A1271
 None
 0.92A 2fr3A-5dotA:
undetectable		 2fr3A-5dotA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		6 PHE A 447
LEU A 445
ILE A 471
ALA A 497
ALA A 499
ARG A 528
 None
 1.41A 2fr3A-5e7jA:
undetectable		 2fr3A-5e7jA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 LEU A  96
ILE A 192
ALA A 193
ALA A 215
THR A 346
 None
 1.04A 2fr3A-5gyzA:
undetectable		 2fr3A-5gyzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 LEU A 206
ILE A  80
ALA A  77
THR A 161
TYR A 261
 None
 1.09A 2fr3A-5hw3A:
undetectable		 2fr3A-5hw3A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  19
PRO A  41
THR A  56
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 (-4.4A)
65X  A 203 (-3.0A)
65X  A 203 (-3.9A)
None
 0.69A 2fr3A-5hz5A:
19.1		 2fr3A-5hz5A:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 ILE A 187
ALA A 188
ALA A 193
THR A 163
VAL A 159
 None
 1.00A 2fr3A-5j8qA:
undetectable		 2fr3A-5j8qA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		5 PHE A  48
LEU A  44
ILE A  90
ALA A  91
VAL A 110
 None
 1.01A 2fr3A-5kbwA:
undetectable		 2fr3A-5kbwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  96
ILE A 192
ALA A 193
ALA A 215
THR A 346
 None
 1.02A 2fr3A-5kyvA:
undetectable		 2fr3A-5kyvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		5 PHE A 321
LEU A 325
ALA A 546
ALA A 549
THR A 524
 None
 0.97A 2fr3A-5mpqA:
undetectable		 2fr3A-5mpqA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		5 LEU A 104
ILE A 154
ALA A 155
ALA A 159
THR A  75
 None
 1.08A 2fr3A-5tgfA:
undetectable		 2fr3A-5tgfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 2 606
ALA 2 648
ALA 2 650
PRO 2 652
TYR 2 657
 None
 1.01A 2fr3A-5udb2:
undetectable		 2fr3A-5udb2:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 6 638
ALA 6 680
PRO 6 684
LEU 6 695
TYR 6 689
 None
 1.05A 2fr3A-5udb6:
undetectable		 2fr3A-5udb6:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		6 ILE A 376
ALA A 375
ALA A 371
PRO A 368
THR A 181
VAL A 160
 None
 1.43A 2fr3A-5x2qA:
undetectable		 2fr3A-5x2qA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		6 PHE A 411
ILE A 376
ALA A 375
ALA A 371
THR A 181
VAL A 160
 None
 1.39A 2fr3A-5x2qA:
undetectable		 2fr3A-5x2qA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		5 PHE A 385
LEU A 389
ILE A 449
ALA A 448
LEU A 338
 None
 1.04A 2fr3A-5xjjA:
undetectable		 2fr3A-5xjjA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S21
40S RIBOSOMAL
PROTEIN SA

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		5 LEU V  78
ILE V  71
ALA V  72
VAL V  52
LEU A 183
 None
 1.10A 2fr3A-5xyiV:
undetectable		 2fr3A-5xyiV:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzx IMPORTIN SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 PHE A 162
LEU A 123
ALA A 136
ALA A 180
THR A 150
 None
 1.04A 2fr3A-5xzxA:
undetectable		 2fr3A-5xzxA:
16.58