SIMILAR PATTERNS OF AMINO ACIDS FOR 2FQG_A_CUA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  60
HIS A  62
HIS A 448
HIS A 450
 CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
 0.22A 2fqgA-1asoA:
29.0		 2fqgA-1asoA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
HIS A 450
HIS A  60
HIS A  62
 CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
 0.85A 2fqgA-1asoA:
29.0		 2fqgA-1asoA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  48
HIS A 118
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.33A 2fqgA-1dfxA:
undetectable		 2fqgA-1dfxA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A  16
HIS A  41
HIS A  47
HIS A 114
 FE  A 200 (-3.3A)
FE  A 200 (-3.3A)
FE  A 200 (-3.4A)
FE  A 200 (-3.2A)
 1.35A 2fqgA-1do6A:
undetectable		 2fqgA-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
 0.22A 2fqgA-1gycA:
32.2		 2fqgA-1gycA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
 0.80A 2fqgA-1gycA:
32.2		 2fqgA-1gycA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 399
HIS A 401
 CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.7A)
CU  A 702 (-3.2A)
 0.85A 2fqgA-1hfuA:
31.9		 2fqgA-1hfuA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 453
HIS A 109
HIS A  64
 CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
CU  A 703 (-3.2A)
CU  A 703 (-4.7A)
 1.15A 2fqgA-1hfuA:
31.9		 2fqgA-1hfuA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 978
HIS A 980
 CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
 0.68A 2fqgA-1kcwA:
13.9		 2fqgA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 161
HIS A 163
HIS A 980
HIS A 103
 CU  A1051 (-3.3A)
CU  A1050 (-3.3A)
CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
 1.33A 2fqgA-1kcwA:
13.9		 2fqgA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 978
HIS A 980
HIS A 101
HIS A 103
 CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 0.87A 2fqgA-1kcwA:
13.9		 2fqgA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 980
HIS A 103
HIS A 161
HIS A 163
 CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
CU  A1050 (-3.3A)
 1.37A 2fqgA-1kcwA:
13.9		 2fqgA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
 0.27A 2fqgA-1kyaA:
32.2		 2fqgA-1kyaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
 0.81A 2fqgA-1kyaA:
32.2		 2fqgA-1kyaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 399
HIS A 401
 CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
 0.21A 2fqgA-1v10A:
32.4		 2fqgA-1v10A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 401
HIS A 451
 CU  A1501 (-3.3A)
CU  A1502 (-3.2A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 1.36A 2fqgA-1v10A:
32.4		 2fqgA-1v10A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 401
HIS A  64
HIS A  66
 CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
 0.80A 2fqgA-1v10A:
32.4		 2fqgA-1v10A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  49
HIS A  69
HIS A  75
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.2A)
 1.33A 2fqgA-1vzhA:
undetectable		 2fqgA-1vzhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A  50
HIS A 122
HIS A  76
HIS A  70
 FE  A 130 (-3.4A)
FE  A 130 (-3.3A)
FE  A 130 (-3.5A)
FE  A 130 (-3.3A)
 1.33A 2fqgA-1y07A:
undetectable		 2fqgA-1y07A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.18A 2fqgA-1zpuA:
30.1		 2fqgA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.78A 2fqgA-1zpuA:
30.1		 2fqgA-1zpuA:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.16A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 141
HIS A 143
HIS A 499
HIS A 501
 C2O  A 602 (-3.2A)
C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.4A)
 1.22A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.79A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.36A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
 0.27A 2fqgA-2hzhA:
32.2		 2fqgA-2hzhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.86A 2fqgA-2hzhA:
32.2		 2fqgA-2hzhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 397
HIS A 399
 CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
 0.27A 2fqgA-2qt6A:
32.3		 2fqgA-2qt6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A  64
HIS A  66
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
 0.83A 2fqgA-2qt6A:
32.3		 2fqgA-2qt6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 397
HIS A 399
HIS A 111
 CU  A 501 (-3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 ( 3.2A)
 1.37A 2fqgA-2qt6A:
32.3		 2fqgA-2qt6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
 0.28A 2fqgA-2xybA:
32.3		 2fqgA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
 0.87A 2fqgA-2xybA:
32.3		 2fqgA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 398
HIS A 400
HIS A 111
 CU  A 502 ( 3.3A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 (-3.2A)
 1.36A 2fqgA-2xybA:
32.3		 2fqgA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A  96
HIS A 401
HIS A 403
 CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
 0.37A 2fqgA-3abgA:
42.3		 2fqgA-3abgA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 403
HIS A  94
HIS A  96
 CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
 0.90A 2fqgA-3abgA:
42.3		 2fqgA-3abgA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.20A 2fqgA-3aw5A:
45.3		 2fqgA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.82A 2fqgA-3aw5A:
45.3		 2fqgA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  93
HIS A  95
HIS A 434
HIS A 436
 CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
 0.25A 2fqgA-3dkhA:
28.7		 2fqgA-3dkhA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 434
HIS A 436
HIS A  93
HIS A  95
 CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
 0.82A 2fqgA-3dkhA:
28.7		 2fqgA-3dkhA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.15A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.34A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 403
HIS A 405
 CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
 0.31A 2fqgA-3kw7A:
32.0		 2fqgA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 109
HIS A 111
HIS A 455
HIS A 457
 CU  A 604 (-3.2A)
CU  A 603 (-3.2A)
CU  A 603 (-3.1A)
CU  A 604 (-3.1A)
 1.17A 2fqgA-3kw7A:
32.0		 2fqgA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 403
HIS A 405
HIS A  64
HIS A  66
 CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
 0.86A 2fqgA-3kw7A:
32.0		 2fqgA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 455
HIS A 403
HIS A 405
HIS A 111
 CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.2A)
 1.33A 2fqgA-3kw7A:
32.0		 2fqgA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 455
HIS A 457
HIS A 109
HIS A 111
 CU  A 603 (-3.1A)
CU  A 604 (-3.1A)
CU  A 604 (-3.2A)
CU  A 603 (-3.2A)
 1.21A 2fqgA-3kw7A:
32.0		 2fqgA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A  96
HIS A 435
HIS A 437
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
 0.24A 2fqgA-3ppsA:
28.4		 2fqgA-3ppsA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 435
HIS A 437
HIS A  94
HIS A  96
 CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.77A 2fqgA-3ppsA:
28.4		 2fqgA-3ppsA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
 0.33A 2fqgA-3pxlA:
32.5		 2fqgA-3pxlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
 0.84A 2fqgA-3pxlA:
32.5		 2fqgA-3pxlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A  67
HIS A 400
HIS A 402
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
 0.23A 2fqgA-3t6wA:
33.1		 2fqgA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A  65
HIS A  67
 CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
 0.81A 2fqgA-3t6wA:
33.1		 2fqgA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A 454
HIS A 110
HIS A 112
 CU  A 503 ( 3.3A)
OXY  A 511 ( 3.2A)
CU  A 502 ( 3.5A)
CU  A 503 (-3.4A)
 1.24A 2fqgA-3t6wA:
33.1		 2fqgA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  87
HIS A  89
HIS A 429
HIS A 431
 CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
 0.49A 2fqgA-3v9eA:
29.8		 2fqgA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 133
HIS A  87
HIS A 431
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 1.35A 2fqgA-3v9eA:
29.8		 2fqgA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 488
HIS A 429
HIS A  89
HIS A 490
 CU  A 602 (-3.1A)
CU  A 602 (-3.6A)
CU  A 603 (-2.9A)
CU  A 603 (-3.5A)
 1.33A 2fqgA-3v9eA:
29.8		 2fqgA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 488
HIS A 429
HIS A 431
HIS A 133
 CU  A 602 (-3.1A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.3A)
 1.36A 2fqgA-3v9eA:
29.8		 2fqgA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  85
HIS A  87
HIS A 420
HIS A 422
 CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
 0.21A 2fqgA-3x1bA:
32.4		 2fqgA-3x1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 420
HIS A 422
HIS A  85
HIS A  87
 CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
 0.81A 2fqgA-3x1bA:
32.4		 2fqgA-3x1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 139
HIS A 141
HIS A 442
HIS A 444
 CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
 0.31A 2fqgA-3zx1A:
44.8		 2fqgA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 442
HIS A 444
HIS A 139
HIS A 141
 CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
 0.81A 2fqgA-3zx1A:
44.8		 2fqgA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 494
HIS A 442
HIS A 444
HIS A 182
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 2.8A)
 1.34A 2fqgA-3zx1A:
44.8		 2fqgA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 105
HIS A 107
HIS A 422
HIS A 424
 CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
 0.16A 2fqgA-4akoA:
44.4		 2fqgA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 422
HIS A 424
HIS A 105
HIS A 107
 CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
 0.75A 2fqgA-4akoA:
44.4		 2fqgA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv1 NEQ011

(Nanoarchaeum
equitans) 		PF01880
(Desulfoferrodox) 		4 HIS A  10
HIS A  35
HIS A  41
HIS A 100
 FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
 1.35A 2fqgA-4bv1A:
undetectable		 2fqgA-4bv1A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv1 NEQ011

(Nanoarchaeum
equitans) 		PF01880
(Desulfoferrodox) 		4 HIS A  35
HIS A  10
HIS A 100
HIS A  41
 FE  A 120 (-3.4A)
FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
FE  A 120 (-3.5A)
 1.34A 2fqgA-4bv1A:
undetectable		 2fqgA-4bv1A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4b SUPEROXIDE REDUCTASE

(Archaeoglobus
fulgidus) 		PF01880
(Desulfoferrodox) 		4 HIS A  14
HIS A 113
HIS A  46
HIS A  40
 FE2  A1001 (-3.4A)
FE2  A1001 (-3.2A)
FE2  A1001 (-3.4A)
FE2  A1001 (-3.4A)
 1.37A 2fqgA-4c4bA:
undetectable		 2fqgA-4c4bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A  19
HIS A 102
HIS A  46
HIS A  40
 FE  A 201 (-3.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.35A 2fqgA-4d7pA:
undetectable		 2fqgA-4d7pA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  82
HIS A  84
HIS A 376
HIS A 378
 None
 0.47A 2fqgA-4f7kA:
34.4		 2fqgA-4f7kA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 376
HIS A 378
HIS A  82
HIS A  84
 None
 0.86A 2fqgA-4f7kA:
34.4		 2fqgA-4f7kA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A   6
HIS A  99
HIS A  97
HIS A  19
 NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
 1.34A 2fqgA-4i7hA:
undetectable		 2fqgA-4i7hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A  99
HIS A   6
HIS A  19
HIS A  97
 NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
 1.22A 2fqgA-4i7hA:
undetectable		 2fqgA-4i7hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 397
HIS A 399
 CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
 0.40A 2fqgA-4jhvA:
32.0		 2fqgA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 109
HIS A  64
HIS A 397
HIS A 451
 CU  A 502 (-3.2A)
CU  A 504 ( 2.8A)
CU  A 504 (-2.7A)
CU  A 502 (-3.3A)
 1.24A 2fqgA-4jhvA:
32.0		 2fqgA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A  64
HIS A  66
 CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
 0.89A 2fqgA-4jhvA:
32.0		 2fqgA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 451
HIS A 109
HIS A  64
 CU  A 504 (-2.7A)
CU  A 502 (-3.3A)
CU  A 502 (-3.2A)
CU  A 504 ( 2.8A)
 1.31A 2fqgA-4jhvA:
32.0		 2fqgA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 397
HIS A  64
HIS A 109
 CU  A 502 (-3.3A)
CU  A 504 (-2.7A)
CU  A 504 ( 2.8A)
CU  A 502 (-3.2A)
 1.23A 2fqgA-4jhvA:
32.0		 2fqgA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
 0.20A 2fqgA-5ehfA:
33.3		 2fqgA-5ehfA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 109
HIS A 111
HIS A 450
HIS A 452
 CU  A 508 (-3.3A)
CU  A 507 ( 3.3A)
CU  A 507 (-3.2A)
CU  A 508 (-3.2A)
 1.20A 2fqgA-5ehfA:
33.3		 2fqgA-5ehfA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
 0.84A 2fqgA-5ehfA:
33.3		 2fqgA-5ehfA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 452
HIS A 109
HIS A 111
 CU  A 507 (-3.2A)
CU  A 508 (-3.2A)
CU  A 508 (-3.3A)
CU  A 507 ( 3.3A)
 1.18A 2fqgA-5ehfA:
33.3		 2fqgA-5ehfA:
24.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A  97
HIS A 396
HIS A 398
 CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
 0.42A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A 137
HIS A 444
HIS A 396
 CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
 1.18A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 135
HIS A  95
HIS A 396
HIS A 446
 CU  A1465 (-3.2A)
CU  A1463 (-4.1A)
CU  A1463 ( 4.8A)
CU  A1465 (-3.3A)
 1.24A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
HIS A 398
HIS A  95
HIS A  97
 CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
 0.84A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 444
HIS A 396
HIS A  95
HIS A 137
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
 1.14A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 444
HIS A 396
HIS A 398
HIS A 137
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.3A)
 1.26A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 108
HIS A 110
HIS A 451
HIS A 453
 CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
 0.28A 2fqgA-5lm8A:
29.6		 2fqgA-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 154
HIS A 108
HIS A 453
HIS A 515
 CU  A 602 ( 3.4A)
CU  A 603 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 1.37A 2fqgA-5lm8A:
29.6		 2fqgA-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 453
HIS A 108
HIS A 110
 CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
 0.88A 2fqgA-5lm8A:
29.6		 2fqgA-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A  67
HIS A 400
HIS A 402
 CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
 0.20A 2fqgA-5mewA:
32.7		 2fqgA-5mewA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A  65
HIS A  67
 CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
 0.77A 2fqgA-5mewA:
32.7		 2fqgA-5mewA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 101
HIS A 103
HIS A 972
HIS A 974
 CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
 0.60A 2fqgA-5n4lA:
25.4		 2fqgA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 972
HIS A 974
HIS A 101
HIS A 103
 CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
 0.72A 2fqgA-5n4lA:
25.4		 2fqgA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  91
HIS A  93
HIS A 437
HIS A 439
 EDO  A 602 ( 4.5A)
None
None
EDO  A 602 (-3.8A)
 0.49A 2fqgA-6evgA:
53.6		 2fqgA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  91
HIS A 133
HIS A 489
HIS A 437
 EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
None
None
 1.12A 2fqgA-6evgA:
53.6		 2fqgA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 437
HIS A 439
HIS A  91
HIS A  93
 None
EDO  A 602 (-3.8A)
EDO  A 602 ( 4.5A)
None
 0.87A 2fqgA-6evgA:
53.6		 2fqgA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 489
HIS A 437
HIS A  91
HIS A 133
 None
None
EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
 1.12A 2fqgA-6evgA:
53.6		 2fqgA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 489
HIS A 437
HIS A 439
HIS A 133
 None
None
EDO  A 602 (-3.8A)
EDO  A 602 (-4.1A)
 1.22A 2fqgA-6evgA:
53.6		 2fqgA-6evgA:
undetectable