SIMILAR PATTERNS OF AMINO ACIDS FOR 2FQG_A_CUA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 445
CYH A 507
HIS A 512
MET A 517
 CU  A 554 (-3.2A)
CU  A 554 (-2.1A)
CU  A 554 (-3.1A)
CU  A 554 (-2.9A)
 0.23A 2fqgA-1asoA:
29.0		 2fqgA-1asoA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3i PROTEIN
(PLASTOCYANIN)

(Prochlorothrix
hollandica) 		PF00127
(Copper-bind) 		4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.68A 2fqgA-1b3iA:
2.9		 2fqgA-1b3iA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxu PLASTOCYANIN

(Synechococcus
elongatus) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 200 ( 3.0A)
CU  A 200 ( 2.1A)
CU  A 200 ( 3.0A)
CU  A 200 ( 2.9A)
 0.33A 2fqgA-1bxuA:
4.2		 2fqgA-1bxuA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byo PROTEIN
(PLASTOCYANIN)

(Silene
latifolia) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 100 ( 3.1A)
CU  A 100 ( 2.1A)
CU  A 100 ( 3.1A)
CU  A 100 ( 2.7A)
 0.38A 2fqgA-1byoA:
3.6		 2fqgA-1byoA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f56 PLANTACYANIN

(Spinacia
oleracea) 		PF02298
(Cu_bind_like) 		4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.53A 2fqgA-1f56A:
0.3		 2fqgA-1f56A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id2 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		4 HIS A  54
CYH A  93
HIS A  96
MET A  99
 CU  A 107 (-3.1A)
CU  A 107 (-2.0A)
CU  A 107 (-3.3A)
CU  A 107 (-2.8A)
 0.58A 2fqgA-1id2A:
2.7		 2fqgA-1id2A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuz PLASTOCYANIN

(Ulva pertusa) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 100 ( 3.2A)
CU  A 100 ( 2.1A)
CU  A 100 ( 3.1A)
CU  A 100 ( 2.6A)
 0.36A 2fqgA-1iuzA:
3.6		 2fqgA-1iuzA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbv MAJOR OUTER MEMBRANE
PROTEIN PAN 1

(Neisseria
gonorrhoeae) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
CYH A 135
HIS A 143
MET A 148
 CU  A 501 (-3.1A)
CU  A 501 (-2.2A)
CU  A 501 (-3.1A)
CU  A 501 (-2.7A)
 0.79A 2fqgA-1kbvA:
21.8		 2fqgA-1kbvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 637
CYH A 680
HIS A 685
MET A 690
 CU  A1053 ( 3.1A)
CU  A1053 ( 2.0A)
CU  A1053 ( 3.1A)
CU  A1053 ( 3.0A)
 0.35A 2fqgA-1kcwA:
13.9		 2fqgA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 975
CYH A1021
HIS A1026
MET A1031
 CU  A1055 ( 3.2A)
CU  A1055 ( 2.0A)
CU  A1055 ( 3.1A)
CU  A1055 ( 3.2A)
 0.32A 2fqgA-1kcwA:
13.9		 2fqgA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda AMICYANIN

(Paracoccus
denitrificans) 		PF00127
(Copper-bind) 		4 HIS A  53
CYH A  92
HIS A  95
MET A  98
 CU  A   0 ( 2.9A)
CU  A   0 ( 2.1A)
CU  A   0 ( 3.1A)
CU  A   0 ( 2.8A)
 0.70A 2fqgA-1mdaA:
3.0		 2fqgA-1mdaA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nds NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
CYH A 136
HIS A 145
MET A 150
 CU  A 501 ( 3.2A)
CU  A 501 ( 2.0A)
CU  A 501 ( 3.1A)
CU  A 501 ( 2.6A)
 0.62A 2fqgA-1ndsA:
undetectable		 2fqgA-1ndsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oow PLASTOCYANIN,
CHLOROPLAST

(Spinacia
oleracea) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 100 (-3.1A)
CU  A 100 (-2.2A)
CU  A 100 (-3.2A)
CU  A 100 (-2.8A)
 0.30A 2fqgA-1oowA:
undetectable		 2fqgA-1oowA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcs PLASTOCYANIN

(Synechocystis
sp. PCC 6803) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 275 ( 3.1A)
CU  A 275 ( 2.2A)
CU  A 275 ( 3.1A)
CU  A 275 ( 2.6A)
 0.36A 2fqgA-1pcsA:
undetectable		 2fqgA-1pcsA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1plb PLASTOCYANIN

(Petroselinum
crispum) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  82
HIS A  85
MET A  90
 CU  A 100 ( 3.2A)
CU  A 100 (-2.0A)
CU  A 100 (-3.3A)
CU  A 100 (-3.1A)
 0.57A 2fqgA-1plbA:
undetectable		 2fqgA-1plbA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmy PSEUDOAZURIN

(Methylobacterium
extorquens) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
HIS A  81
MET A  86
 CU  A 124 (-3.1A)
CU  A 124 (-2.1A)
CU  A 124 (-3.1A)
CU  A 124 (-2.6A)
 0.46A 2fqgA-1pmyA:
undetectable		 2fqgA-1pmyA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhq PROTEIN (AURACYANIN)

(Chloroflexus
aurantiacus) 		PF00127
(Copper-bind) 		4 HIS A  57
CYH A 122
HIS A 127
MET A 132
 CU  A 141 ( 3.1A)
CU  A 141 ( 2.1A)
CU  A 141 (-3.1A)
CU  A 141 ( 2.8A)
 0.43A 2fqgA-1qhqA:
3.7		 2fqgA-1qhqA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		4 HIS A  85
CYH A 138
HIS A 143
MET A 148
 CU  A 156 ( 3.1A)
CU  A 156 ( 2.2A)
CU  A 156 ( 3.0A)
CU  A 156 ( 2.8A)
 0.32A 2fqgA-1rcyA:
4.3		 2fqgA-1rcyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		4 HIS A  46
CYH A 112
HIS A 117
MET A 121
 CU  A 200 (-3.1A)
CU  A 200 (-2.1A)
CU  A 200 (-3.0A)
CU  A 200 (-3.1A)
 0.51A 2fqgA-1rkrA:
3.2		 2fqgA-1rkrA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uat AZURIN ISO-2

(Methylomonas
sp. J) 		PF00127
(Copper-bind) 		4 HIS A  46
CYH A 112
HIS A 117
MET A 121
 CU  A 130 (-3.2A)
CU  A 130 (-2.1A)
CU  A 130 (-3.1A)
CU  A 130 (-3.0A)
 0.47A 2fqgA-1uatA:
3.2		 2fqgA-1uatA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aan AURACYANIN A

(Chloroflexus
aurantiacus) 		PF00127
(Copper-bind) 		4 HIS A  58
CYH A 123
HIS A 128
MET A 132
 CU  A 140 (-3.1A)
CU  A 140 (-2.2A)
CU  A 140 (-3.1A)
CU  A 140 (-2.9A)
 0.37A 2fqgA-2aanA:
3.7		 2fqgA-2aanA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
CYH A 136
HIS A 145
MET A 150
 CU  A 501 (-3.2A)
CU  A 501 (-2.3A)
CU  A 501 (-3.2A)
CU  A 501 (-2.3A)
 0.68A 2fqgA-2avfA:
20.4		 2fqgA-2avfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bz7 PLASTOCYANIN

(Dryopteris
crassirhizoma) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  87
HIS A  90
MET A  95
 CU  A 103 (-3.1A)
CU  A 103 (-2.2A)
CU  A 103 (-3.2A)
CU  A 103 (-2.8A)
 0.29A 2fqgA-2bz7A:
undetectable		 2fqgA-2bz7A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbp CUCUMBER BASIC
PROTEIN

(Cucumis sativus) 		PF02298
(Cu_bind_like) 		4 HIS A  39
CYH A  79
HIS A  84
MET A  89
 CU  A  97 (-3.0A)
CU  A  97 (-2.1A)
CU  A  97 (-3.0A)
CU  A  97 (-2.6A)
 0.51A 2fqgA-2cbpA:
undetectable		 2fqgA-2cbpA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cj3 PLASTOCYANIN

(Nostoc sp. PCC
7120) 		PF00127
(Copper-bind) 		4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU  A 106 (-3.1A)
CU  A 106 (-2.1A)
CU  A 106 (-3.1A)
CU  A 106 (-2.8A)
 0.30A 2fqgA-2cj3A:
undetectable		 2fqgA-2cj3A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 HIS A  77
CYH A 114
HIS A 119
MET A 124
 CU  A 502 (-3.2A)
CU  A 502 (-2.2A)
CU  A 502 (-3.1A)
CU  A 502 (-2.8A)
 0.50A 2fqgA-2dv6A:
21.7		 2fqgA-2dv6A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 HIS A 219
CYH A 260
HIS A 268
MET A 273
 CU  A 500 (-3.2A)
CU  A 500 (-2.1A)
CU  A 500 (-3.1A)
CU  A 500 (-2.5A)
 0.76A 2fqgA-2dv6A:
21.7		 2fqgA-2dv6A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A 126
CYH A 167
HIS A 177
MET A 182
 CU  A 401 (-3.2A)
CU  A 401 (-2.2A)
CU  A 401 (-3.1A)
CU  A 401 (-2.4A)
 0.62A 2fqgA-2dwsA:
20.5		 2fqgA-2dwsA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 443
CYH A 500
HIS A 505
MET A 510
 CU  A 601 (-3.2A)
CU  A 601 (-2.2A)
CU  A 601 (-3.3A)
CU  A 601 (-3.3A)
 0.17A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft7 AZURIN

(Pseudomonas
aeruginosa) 		PF00127
(Copper-bind) 		4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.41A 2fqgA-2ft7A:
undetectable		 2fqgA-2ft7A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaa AZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		4 HIS C  46
CYH C 112
HIS C 117
MET C 121
 CU  C 130 (-3.3A)
CU  C 130 (-2.4A)
CU  C 130 (-3.3A)
CU  C 130 (-3.0A)
 0.61A 2fqgA-2iaaC:
3.1		 2fqgA-2iaaC:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0m LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.59A 2fqgA-2n0mA:
3.4		 2fqgA-2n0mA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plt PLASTOCYANIN

(Chlamydomonas
reinhardtii) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 100 (-3.1A)
CU  A 100 (-2.1A)
CU  A 100 (-3.1A)
CU  A 100 (-2.8A)
 0.34A 2fqgA-2pltA:
undetectable		 2fqgA-2pltA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 0.99A 2fqgA-2r7eB:
17.8		 2fqgA-2r7eB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux7 PSEUDOAZURIN

(Achromobacter
cycloclastes) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
HIS A  81
MET A  84
 CU  A1123 (-3.1A)
CU  A1123 (-2.1A)
CU  A1123 (-3.6A)
CU  A1123 (-2.3A)
 0.46A 2fqgA-2ux7A:
undetectable		 2fqgA-2ux7A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  89
CYH A 130
HIS A 133
MET A 136
 ZN  A1330 (-3.6A)
ZN  A1330 (-2.1A)
ZN  A1330 (-3.4A)
ZN  A1330 (-3.5A)
 0.73A 2fqgA-2vmjA:
18.3		 2fqgA-2vmjA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  84
CYH A 125
HIS A 133
MET A 138
 CU  A 500 (-3.2A)
CU  A 500 (-2.2A)
CU  A 500 (-3.1A)
CU  A 500 (-2.5A)
 0.74A 2fqgA-2zooA:
21.8		 2fqgA-2zooA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
CYH A 457
HIS A 462
MET A 467
 CU  A 704 (-3.5A)
CU  A 704 (-2.3A)
CU  A 704 (-3.2A)
CU  A 704 (-3.5A)
 0.26A 2fqgA-3abgA:
42.3		 2fqgA-3abgA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 391
CYH A 460
HIS A 465
MET A 470
 CU  A 701 (-3.1A)
CU  A 701 (-2.1A)
CU  A 701 (-3.2A)
CU  A 701 (-3.4A)
 0.17A 2fqgA-3aw5A:
45.3		 2fqgA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay2 LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		4 HIS A 102
CYH A 166
HIS A 171
MET A 175
 ZN  A1001 (-3.0A)
ZN  A1001 (-2.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-3.5A)
 0.49A 2fqgA-3ay2A:
3.3		 2fqgA-3ay2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 AMICYANIN

(Paracoccus
versutus) 		PF00127
(Copper-bind) 		4 HIS A  54
CYH A  93
HIS A  96
MET A  99
 CU  A 107 (-3.1A)
CU  A 107 (-2.1A)
CU  A 107 (-3.3A)
CU  A 107 (-2.7A)
 0.60A 2fqgA-3c75A:
undetectable		 2fqgA-3c75A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvd PLASTOCYANIN

(Phormidium
laminosum) 		PF00127
(Copper-bind) 		4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.38A 2fqgA-3cvdA:
undetectable		 2fqgA-3cvdA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  99
CYH A 147
HIS A 154
MET A 160
 CU  A   1 (-3.2A)
CU  A   1 (-2.1A)
CU  A   1 (-3.2A)
CU  A   1 (-2.8A)
 0.55A 2fqgA-3g5wA:
23.4		 2fqgA-3g5wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 524
CYH A 603
HIS A 608
MET A 613
 CU  A1000 (-3.0A)
CU  A1000 (-2.2A)
CU  A1000 (-3.6A)
CU  A1000 (-3.5A)
 0.30A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
CYH A 136
HIS A 145
MET A 150
 CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
 0.62A 2fqgA-3h4hA:
20.4		 2fqgA-3h4hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 None
 0.66A 2fqgA-3j2sB:
17.3		 2fqgA-3j2sB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 231
CYH A 288
HIS A 293
MET A 298
 CU  A 401 (-3.0A)
CU  A 401 (-2.1A)
CU  A 401 (-3.0A)
CU  A 401 (-3.4A)
 0.48A 2fqgA-3kw8A:
undetectable		 2fqgA-3kw8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 219
CYH A 276
HIS A 281
MET A 286
 CU  A 311 (-3.1A)
CU  A 311 (-2.1A)
CU  A 311 (-3.1A)
CU  A 311 (-3.3A)
 0.45A 2fqgA-3t9wA:
undetectable		 2fqgA-3t9wA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 226
CYH A 283
HIS A 288
MET A 293
 CU  A   5 (-3.2A)
CU  A   5 (-2.2A)
CU  A   5 (-3.0A)
CU  A   5 ( 3.7A)
 0.53A 2fqgA-3tbbA:
undetectable		 2fqgA-3tbbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu6 PSEUDOAZURIN (BLUE
COPPER PROTEIN)

(Sinorhizobium
meliloti) 		PF00127
(Copper-bind) 		4 HIS A  42
CYH A  80
HIS A  83
MET A  88
 CU  A 201 (-3.1A)
CU  A 201 (-2.2A)
CU  A 201 (-3.1A)
CU  A 201 (-2.5A)
 0.42A 2fqgA-3tu6A:
undetectable		 2fqgA-3tu6A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 426
CYH A 489
HIS A 494
MET A 499
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 (-3.1A)
CU  A 601 (-3.1A)
 0.17A 2fqgA-3v9eA:
29.8		 2fqgA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
CYH A 135
HIS A 143
MET A 148
 CU  A 401 (-3.1A)
CU  A 401 (-2.0A)
CU  A 401 (-3.0A)
CU  A 401 (-2.6A)
 0.70A 2fqgA-3wiaA:
21.4		 2fqgA-3wiaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
CYH A 135
HIS A 143
MET A 148
 CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.1A)
CU  A 401 (-3.7A)
 0.83A 2fqgA-3wkqA:
21.5		 2fqgA-3wkqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 HIS A  94
CYH A 135
HIS A 143
MET A 148
 CU  A1460 (-3.1A)
CU  A1460 (-2.1A)
CU  A1460 (-3.1A)
CU  A1460 (-2.6A)
 0.75A 2fqgA-3zbmA:
22.2		 2fqgA-3zbmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 439
CYH A 495
HIS A 500
MET A 505
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 (-3.1A)
CU  A 601 (-3.3A)
 0.12A 2fqgA-3zx1A:
44.8		 2fqgA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 419
CYH A 492
HIS A 497
MET A 502
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 (-3.1A)
CU  A 601 (-3.2A)
 0.14A 2fqgA-4akoA:
44.3		 2fqgA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxv PSEUDOAZURIN

(Paracoccus
pantotrophus) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
HIS A  81
MET A  86
 CU  A1124 (-3.5A)
CU  A1124 (-2.6A)
CU  A1124 (-4.2A)
CU  A1124 (-2.8A)
 0.68A 2fqgA-4bxvA:
undetectable		 2fqgA-4bxvA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dp0 PLASTOCYANIN B,
CHLOROPLASTIC

(Populus nigra) 		PF00127
(Copper-bind) 		4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU  X 100 (-3.1A)
CU  X 100 (-2.2A)
CU  X 100 ( 3.1A)
CU  X 100 (-2.5A)
 0.37A 2fqgA-4dp0X:
undetectable		 2fqgA-4dp0X:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpc PLASTOCYANIN A,
CHLOROPLASTIC

(Populus nigra) 		PF00127
(Copper-bind) 		4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.34A 2fqgA-4dpcX:
undetectable		 2fqgA-4dpcX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1057
CYH A1105
HIS A1112
MET A1118
 CU  A1401 (-3.1A)
CU  A1401 (-2.2A)
CU  A1401 (-3.1A)
CU  A1401 (-2.7A)
 0.50A 2fqgA-4e9xA:
23.4		 2fqgA-4e9xA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 231
CYH A 288
HIS A 293
MET A 298
 CU  A 401 (-3.1A)
CU  A 401 (-2.2A)
CU  A 401 (-3.0A)
CU  A 401 (-3.5A)
 0.50A 2fqgA-4gybA:
undetectable		 2fqgA-4gybA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hci CUPREDOXIN 1

(Bacillus
anthracis) 		PF13473
(Cupredoxin_1) 		4 HIS A  79
CYH A 114
HIS A 117
MET A 122
 None
 0.59A 2fqgA-4hciA:
4.1		 2fqgA-4hciA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		4 HIS A  83
CYH A 123
HIS A 131
MET A 136
 CU  A 408 (-3.2A)
CU  A 408 (-2.2A)
CU  A 408 (-3.1A)
CU  A 408 (-2.4A)
 0.72A 2fqgA-4kntA:
22.1		 2fqgA-4kntA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 228
CYH A 285
HIS A 290
MET A 295
 CU  A 402 (-3.1A)
CU  A 402 (-2.1A)
CU  A 402 (-3.0A)
CU  A 402 (-3.3A)
 0.46A 2fqgA-4w1tA:
undetectable		 2fqgA-4w1tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5akr COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
CYH A 136
HIS A 145
MET A 150
 CU  A 501 (-3.1A)
CU  A 501 (-2.2A)
CU  A 501 (-3.1A)
CU  A 501 (-2.4A)
 0.61A 2fqgA-5akrA:
20.5		 2fqgA-5akrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1j BLUE COPPER PROTEIN

(Hyphomicrobium
denitrificans) 		PF00127
(Copper-bind) 		4 HIS C  41
CYH C  79
HIS C  82
MET C  87
 CU  C 401 (-3.3A)
CU  C 401 (-2.1A)
CU  C 401 (-3.1A)
CU  C 401 (-2.4A)
 0.49A 2fqgA-5b1jC:
undetectable		 2fqgA-5b1jC:
13.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 393
CYH A 445
HIS A 450
MET A 455
 CU  A1464 (-3.1A)
CU  A1464 (-2.1A)
CU  A1464 (-3.2A)
CU  A1464 ( 3.4A)
 0.21A 2fqgA-5g3fA:
48.4		 2fqgA-5g3fA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A 267
CYH A 310
HIS A 232
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.6A)
CU  A 808 ( 4.8A)
 1.18A 2fqgA-5k8dA:
16.4		 2fqgA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.70A 2fqgA-5k8dB:
18.0		 2fqgA-5k8dB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 4 HIS A 232
CYH A 289
HIS A 294
MET A 299
 CU  A 401 (-3.1A)
CU  A 401 (-2.1A)
CU  A 401 (-3.0A)
CU  A 401 (-3.3A)
 0.49A 2fqgA-5mkmA:
17.9		 2fqgA-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 631
CYH A 674
HIS A 679
MET A 684
 None
 0.59A 2fqgA-5n4lA:
25.4		 2fqgA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 969
CYH A1015
HIS A1020
MET A1025
 CU  A1102 (-3.0A)
CU  A1102 (-1.9A)
CU  A1102 (-3.2A)
CU  A1102 (-3.2A)
 0.33A 2fqgA-5n4lA:
25.4		 2fqgA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syd AZURIN, CHIMERIC
CONSTRUCT

(Pseudomonas
aeruginosa) 		PF00127
(Copper-bind) 		4 HIS A   6
CYH A  72
HIS A  77
MET A  81
 CU  A 202 (-3.3A)
CU  A 202 (-2.4A)
CU  A 202 (-3.4A)
CU  A 202 (-2.8A)
 0.52A 2fqgA-5sydA:
undetectable		 2fqgA-5sydA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7n CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		no annotation 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.49A 2fqgA-5u7nA:
3.1		 2fqgA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt7 -

(-) 		no annotation 4 HIS A  65
CYH A 131
HIS A   3
MET A   7
 CU  A 201 (-3.1A)
CU  A 201 (-2.1A)
CU  A 201 (-3.1A)
CU  A 201 (-3.2A)
 0.50A 2fqgA-5yt7A:
undetectable		 2fqgA-5yt7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 434
CYH A 490
HIS A 495
MET A 500
 CU  A 601 (-3.1A)
CU  A 601 (-2.1A)
CU  A 601 (-3.1A)
CU  A 601 (-3.3A)
 0.17A 2fqgA-6evgA:
53.6		 2fqgA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7paz PSEUDOAZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
HIS A  81
MET A  86
 CU  A 124 ( 3.1A)
CU  A 124 ( 2.1A)
CU  A 124 ( 3.2A)
CU  A 124 ( 2.9A)
 0.35A 2fqgA-7pazA:
undetectable		 2fqgA-7pazA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7pcy PLASTOCYANIN

(Ulva prolifera) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 100 (-3.0A)
CU  A 100 (-2.1A)
CU  A 100 (-3.2A)
CU  A 100 (-2.9A)
 0.33A 2fqgA-7pcyA:
undetectable		 2fqgA-7pcyA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9pcy PLASTOCYANIN

(Phaseolus
vulgaris) 		PF00127
(Copper-bind) 		4 HIS A  37
CYH A  84
HIS A  87
MET A  92
 CU  A 100 (-3.1A)
CU  A 100 (-2.1A)
CU  A 100 (-3.2A)
CU  A 100 (-2.9A)
 0.43A 2fqgA-9pcyA:
undetectable		 2fqgA-9pcyA:
11.07