SIMILAR PATTERNS OF AMINO ACIDS FOR 2FQE_A_CUA603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  60
HIS A  62
HIS A 448
HIS A 450
 CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
 0.25A 2fqeA-1asoA:
29.0		 2fqeA-1asoA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
HIS A 450
HIS A  60
HIS A  62
 CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
 0.88A 2fqeA-1asoA:
29.0		 2fqeA-1asoA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
 0.30A 2fqeA-1gycA:
32.3		 2fqeA-1gycA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
 0.84A 2fqeA-1gycA:
32.3		 2fqeA-1gycA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 399
HIS A 401
 CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.7A)
CU  A 702 (-3.2A)
 0.75A 2fqeA-1hfuA:
32.0		 2fqeA-1hfuA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 978
HIS A 980
 CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
 0.74A 2fqeA-1kcwA:
13.9		 2fqeA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 978
HIS A 980
HIS A 101
HIS A 103
 CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 0.94A 2fqeA-1kcwA:
13.9		 2fqeA-1kcwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
 0.34A 2fqeA-1kyaA:
32.4		 2fqeA-1kyaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
 0.86A 2fqeA-1kyaA:
32.4		 2fqeA-1kyaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 399
HIS A 401
 CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
 0.26A 2fqeA-1v10A:
32.4		 2fqeA-1v10A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 401
HIS A 451
 CU  A1501 (-3.3A)
CU  A1502 (-3.2A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 1.29A 2fqeA-1v10A:
32.4		 2fqeA-1v10A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 401
HIS A  64
HIS A  66
 CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
 0.84A 2fqeA-1v10A:
32.4		 2fqeA-1v10A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  49
HIS A  69
HIS A  75
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.2A)
 1.37A 2fqeA-1vzhA:
undetectable		 2fqeA-1vzhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  75
HIS A 119
HIS A  49
HIS A  69
 FE  A1129 ( 3.4A)
FE  A1129 ( 3.2A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
 1.30A 2fqeA-1vzhA:
undetectable		 2fqeA-1vzhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A  76
HIS A 122
HIS A  50
HIS A  70
 FE  A 130 (-3.5A)
FE  A 130 (-3.3A)
FE  A 130 (-3.4A)
FE  A 130 (-3.3A)
 1.32A 2fqeA-1y07A:
undetectable		 2fqeA-1y07A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.30A 2fqeA-1zpuA:
30.2		 2fqeA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.83A 2fqeA-1zpuA:
30.2		 2fqeA-1zpuA:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.15A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 143
HIS A 101
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 1.35A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.80A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  25
HIS A 114
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-3.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.37A 2fqeA-2hvbA:
undetectable		 2fqeA-2hvbA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  56
HIS A 114
HIS A  25
HIS A  50
 FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.5A)
 1.29A 2fqeA-2hvbA:
undetectable		 2fqeA-2hvbA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
 0.29A 2fqeA-2hzhA:
32.3		 2fqeA-2hzhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.89A 2fqeA-2hzhA:
32.3		 2fqeA-2hzhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A  76
HIS A 137
HIS A 248
HIS A 285
 ZN  A 493 (-3.5A)
None
ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
 1.34A 2fqeA-2pajA:
undetectable		 2fqeA-2pajA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 397
HIS A 399
 CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
 0.30A 2fqeA-2qt6A:
32.4		 2fqeA-2qt6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A  64
HIS A  66
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
 0.86A 2fqeA-2qt6A:
32.4		 2fqeA-2qt6A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
 0.32A 2fqeA-2xybA:
32.4		 2fqeA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 400
HIS A 450
 CU  A 502 (-3.2A)
CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 1.34A 2fqeA-2xybA:
32.4		 2fqeA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
 0.90A 2fqeA-2xybA:
32.4		 2fqeA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 398
HIS A 400
HIS A 111
 CU  A 502 ( 3.3A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 (-3.2A)
 1.30A 2fqeA-2xybA:
32.4		 2fqeA-2xybA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.32A 2fqeA-2z4gA:
undetectable		 2fqeA-2z4gA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A  96
HIS A 401
HIS A 403
 CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
 0.40A 2fqeA-3abgA:
42.3		 2fqeA-3abgA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 403
HIS A  94
HIS A  96
 CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
 0.95A 2fqeA-3abgA:
42.3		 2fqeA-3abgA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.21A 2fqeA-3aw5A:
45.4		 2fqeA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.83A 2fqeA-3aw5A:
45.4		 2fqeA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 459
HIS A 394
HIS A 396
HIS A 134
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.3A)
 1.35A 2fqeA-3aw5A:
45.4		 2fqeA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  93
HIS A  95
HIS A 434
HIS A 436
 CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
 0.31A 2fqeA-3dkhA:
28.8		 2fqeA-3dkhA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 434
HIS A 436
HIS A  93
HIS A  95
 CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
 0.86A 2fqeA-3dkhA:
28.8		 2fqeA-3dkhA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.30A 2fqeA-3gyrA:
37.3		 2fqeA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.87A 2fqeA-3gyrA:
37.3		 2fqeA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 403
HIS A 405
 CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
 0.31A 2fqeA-3kw7A:
32.0		 2fqeA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 405
HIS A 455
 CU  A 603 (-3.2A)
CU  A 602 (-3.1A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 1.31A 2fqeA-3kw7A:
32.0		 2fqeA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 403
HIS A 405
HIS A  64
HIS A  66
 CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
 0.89A 2fqeA-3kw7A:
32.0		 2fqeA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 455
HIS A 403
HIS A 405
HIS A 111
 CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.2A)
 1.24A 2fqeA-3kw7A:
32.0		 2fqeA-3kw7A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A  96
HIS A 435
HIS A 437
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
 0.34A 2fqeA-3ppsA:
28.5		 2fqeA-3ppsA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 141
HIS A  94
HIS A 437
HIS A 503
 CU  A 602 ( 3.3A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
 1.37A 2fqeA-3ppsA:
28.5		 2fqeA-3ppsA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 435
HIS A 437
HIS A  94
HIS A  96
 CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.82A 2fqeA-3ppsA:
28.5		 2fqeA-3ppsA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
 0.31A 2fqeA-3pxlA:
32.6		 2fqeA-3pxlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
 0.84A 2fqeA-3pxlA:
32.6		 2fqeA-3pxlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A  17
HIS A  45
HIS A  51
HIS A 118
 FE  A 132 (-3.4A)
FE  A 132 (-3.4A)
FE  A 132 (-3.4A)
FE  A 132 (-3.3A)
 1.36A 2fqeA-3qzbA:
undetectable		 2fqeA-3qzbA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A  67
HIS A 400
HIS A 402
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
 0.27A 2fqeA-3t6wA:
33.3		 2fqeA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 112
HIS A  65
HIS A 402
HIS A 452
 CU  A 503 (-3.4A)
CU  A 504 (-3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 1.32A 2fqeA-3t6wA:
33.3		 2fqeA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A  65
HIS A  67
 CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
 0.84A 2fqeA-3t6wA:
33.3		 2fqeA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A 400
HIS A 402
HIS A 112
 CU  A 503 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 503 (-3.4A)
 1.37A 2fqeA-3t6wA:
33.3		 2fqeA-3t6wA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  87
HIS A  89
HIS A 429
HIS A 431
 CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
 0.34A 2fqeA-3v9eA:
29.9		 2fqeA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 133
HIS A  87
HIS A 431
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 1.28A 2fqeA-3v9eA:
29.9		 2fqeA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 488
HIS A 429
HIS A 431
HIS A 133
 CU  A 602 (-3.1A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.3A)
 1.32A 2fqeA-3v9eA:
29.9		 2fqeA-3v9eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  85
HIS A  87
HIS A 420
HIS A 422
 CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
 0.27A 2fqeA-3x1bA:
32.5		 2fqeA-3x1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 420
HIS A 422
HIS A  85
HIS A  87
 CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
 0.85A 2fqeA-3x1bA:
32.5		 2fqeA-3x1bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 139
HIS A 141
HIS A 442
HIS A 444
 CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
 0.29A 2fqeA-3zx1A:
44.8		 2fqeA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 182
HIS A 139
HIS A 444
HIS A 494
 CU  A 603 ( 2.8A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
 1.36A 2fqeA-3zx1A:
44.8		 2fqeA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 442
HIS A 444
HIS A 139
HIS A 141
 CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
 0.83A 2fqeA-3zx1A:
44.8		 2fqeA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 494
HIS A 442
HIS A 444
HIS A 182
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 2.8A)
 1.24A 2fqeA-3zx1A:
44.8		 2fqeA-3zx1A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 105
HIS A 107
HIS A 422
HIS A 424
 CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
 0.25A 2fqeA-4akoA:
44.2		 2fqeA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 155
HIS A 105
HIS A 424
HIS A 491
 CU  A 603 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 1.32A 2fqeA-4akoA:
44.2		 2fqeA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 422
HIS A 424
HIS A 105
HIS A 107
 CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
 0.79A 2fqeA-4akoA:
44.2		 2fqeA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 491
HIS A 422
HIS A 424
HIS A 155
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.2A)
 1.33A 2fqeA-4akoA:
44.2		 2fqeA-4akoA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 179
HIS A  69
HIS A 210
HIS A 209
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.3A)
None
 1.34A 2fqeA-4bedA:
undetectable		 2fqeA-4bedA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2260
HIS B2150
HIS B2291
HIS B2290
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.3A)
CUO  B9006 (-3.5A)
None
 1.37A 2fqeA-4bedB:
undetectable		 2fqeA-4bedB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.33A 2fqeA-4brjA:
undetectable		 2fqeA-4brjA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv1 NEQ011

(Nanoarchaeum
equitans) 		PF01880
(Desulfoferrodox) 		4 HIS A  41
HIS A 100
HIS A  10
HIS A  35
 FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
 1.33A 2fqeA-4bv1A:
undetectable		 2fqeA-4bv1A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A  19
HIS A 102
HIS A  46
HIS A  40
 FE  A 201 (-3.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.37A 2fqeA-4d7pA:
undetectable		 2fqeA-4d7pA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A  46
HIS A 102
HIS A  19
HIS A  40
 FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
FE  A 201 (-3.4A)
 1.30A 2fqeA-4d7pA:
undetectable		 2fqeA-4d7pA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  82
HIS A  84
HIS A 376
HIS A 378
 None
 0.29A 2fqeA-4f7kA:
34.5		 2fqeA-4f7kA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 376
HIS A 378
HIS A  82
HIS A  84
 None
 0.80A 2fqeA-4f7kA:
34.5		 2fqeA-4f7kA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A  99
HIS A   6
HIS A  19
HIS A  97
 NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
 1.28A 2fqeA-4i7hA:
undetectable		 2fqeA-4i7hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 397
HIS A 399
 CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
 0.25A 2fqeA-4jhvA:
32.2		 2fqeA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A  64
HIS A  66
 CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
 0.85A 2fqeA-4jhvA:
32.2		 2fqeA-4jhvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A  56
HIS A 241
HIS A 209
HIS A 117
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 ( 3.4A)
None
 1.20A 2fqeA-4r85A:
undetectable		 2fqeA-4r85A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A 209
HIS A 117
HIS A  56
HIS A 241
 FE2  A 502 ( 3.4A)
None
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.7A)
 1.34A 2fqeA-4r85A:
undetectable		 2fqeA-4r85A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 153
HIS A 116
HIS A 297
HIS A 157
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 1.07A 2fqeA-4ymkA:
undetectable		 2fqeA-4ymkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A  66
HIS A 398
HIS A 400
 CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
 0.30A 2fqeA-5ehfA:
33.2		 2fqeA-5ehfA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A  64
HIS A 400
HIS A 450
 CU  A 507 ( 3.3A)
CU  A 509 (-3.2A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 1.30A 2fqeA-5ehfA:
33.2		 2fqeA-5ehfA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A  64
HIS A  66
 CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
 0.89A 2fqeA-5ehfA:
33.2		 2fqeA-5ehfA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 398
HIS A 400
HIS A 111
 CU  A 507 (-3.2A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 ( 3.3A)
 1.32A 2fqeA-5ehfA:
33.2		 2fqeA-5ehfA:
24.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A  97
HIS A 396
HIS A 398
 CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
 0.23A 2fqeA-5g3fA:
48.6		 2fqeA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  95
HIS A 137
HIS A 444
HIS A 396
 CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
 1.23A 2fqeA-5g3fA:
48.6		 2fqeA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
HIS A 398
HIS A  95
HIS A  97
 CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
 0.77A 2fqeA-5g3fA:
48.6		 2fqeA-5g3fA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 444
HIS A 396
HIS A 398
HIS A 137
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.3A)
 1.15A 2fqeA-5g3fA:
48.6		 2fqeA-5g3fA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 108
HIS A 110
HIS A 451
HIS A 453
 CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
 0.22A 2fqeA-5lm8A:
29.6		 2fqeA-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 453
HIS A 108
HIS A 110
 CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
 0.89A 2fqeA-5lm8A:
29.6		 2fqeA-5lm8A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A  67
HIS A 400
HIS A 402
 CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
 0.25A 2fqeA-5mewA:
32.8		 2fqeA-5mewA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A  65
HIS A  67
 CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
 0.80A 2fqeA-5mewA:
32.8		 2fqeA-5mewA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 101
HIS A 103
HIS A 972
HIS A 974
 CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
 0.61A 2fqeA-5n4lA:
25.5		 2fqeA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 972
HIS A 974
HIS A 101
HIS A 103
 CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
 0.76A 2fqeA-5n4lA:
25.5		 2fqeA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A  91
HIS A  93
HIS A 437
HIS A 439
 EDO  A 602 ( 4.5A)
None
None
EDO  A 602 (-3.8A)
 0.34A 2fqeA-6evgA:
53.6		 2fqeA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 437
HIS A 439
HIS A  91
HIS A  93
 None
EDO  A 602 (-3.8A)
EDO  A 602 ( 4.5A)
None
 0.81A 2fqeA-6evgA:
53.6		 2fqeA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 489
HIS A 437
HIS A 439
HIS A 133
 None
None
EDO  A 602 (-3.8A)
EDO  A 602 (-4.1A)
 1.10A 2fqeA-6evgA:
53.6		 2fqeA-6evgA:
undetectable