SIMILAR PATTERNS OF AMINO ACIDS FOR 2FN1_B_SALB503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		5 GLY A  24
THR A  23
THR A  30
ARG A  11
GLY A 212
 None
 1.00A 2fn1B-1b65A:
undetectable		 2fn1B-1b65A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		5 ILE A  29
GLY A  24
THR A  30
ARG A  11
GLY A 212
 None
 1.07A 2fn1B-1b65A:
undetectable		 2fn1B-1b65A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		5 ILE A  36
GLU A  39
HIS A 259
GLY A  66
GLU A  71
 None
 1.43A 2fn1B-1e2tA:
undetectable		 2fn1B-1e2tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ILE A 524
GLY A 372
HIS A 371
ARG A 476
GLY A 523
 None
 1.16A 2fn1B-1evlA:
undetectable		 2fn1B-1evlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 ILE A 202
GLU A 154
GLY A 171
THR A 170
THR A 199
 ILE  A 202 ( 0.7A)
GLU  A 154 ( 0.6A)
GLY  A 171 ( 0.0A)
THR  A 170 ( 0.8A)
THR  A 199 ( 0.8A)
 1.23A 2fn1B-1fxjA:
undetectable		 2fn1B-1fxjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		10 GLU A 309
GLY A 328
THR A 329
GLU A 361
HIS A 398
THR A 425
ARG A 469
GLY A 485
GLU A 498
LYS A 502
 BEZ  A1501 (-3.8A)
BEZ  A1501 (-3.3A)
BEZ  A1501 (-3.9A)
MG  A1701 ( 3.1A)
BEZ  A1501 ( 4.2A)
BEZ  A1501 (-4.7A)
PYR  A1601 ( 3.9A)
BEZ  A1501 (-3.8A)
MG  A1701 ( 2.6A)
BEZ  A1501 ( 2.9A)
 0.41A 2fn1B-1i7qA:
41.7		 2fn1B-1i7qA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 309
THR A 329
HIS A 398
GLY A 483
GLU A 498
 BEZ  A1501 (-3.8A)
BEZ  A1501 (-3.9A)
BEZ  A1501 ( 4.2A)
PYR  A1601 (-3.8A)
MG  A1701 ( 2.6A)
 1.36A 2fn1B-1i7qA:
41.7		 2fn1B-1i7qA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		7 GLY A 328
THR A 329
GLU A 358
HIS A 398
ARG A 469
GLU A 498
LYS A 502
 BEZ  A1501 (-3.3A)
BEZ  A1501 (-3.9A)
MG  A1701 ( 4.3A)
BEZ  A1501 ( 4.2A)
PYR  A1601 ( 3.9A)
MG  A1701 ( 2.6A)
BEZ  A1501 ( 2.9A)
 1.39A 2fn1B-1i7qA:
41.7		 2fn1B-1i7qA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 ILE A 268
GLU A 298
GLY A 313
THR A 310
GLY A 275
 None
 1.14A 2fn1B-1in8A:
undetectable		 2fn1B-1in8A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 258
ARG A 410
GLY A 426
GLU A 439
LYS A 443
 None
 1.05A 2fn1B-1k0gA:
36.6		 2fn1B-1k0gA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 ILE A 154
GLY A 112
HIS A  21
THR A 155
GLY A 123
 None
None
None
PQQ  A 801 (-2.8A)
None
 1.30A 2fn1B-1kv9A:
undetectable		 2fn1B-1kv9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLU A 163
GLY A 140
THR A 129
GLY A 167
GLU A 173
 None
 1.41A 2fn1B-1kwmA:
undetectable		 2fn1B-1kwmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLU A 163
GLY A 140
THR A 129
GLY A 167
GLU A 173
 None
 1.43A 2fn1B-1nsaA:
undetectable		 2fn1B-1nsaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqz MCMV M144

(Murid
betaherpesvirus
1) 		PF07654
(C1-set) 		5 GLU A  36
GLY A  31
THR A  30
HIS A  32
GLY A  48
 None
 1.42A 2fn1B-1pqzA:
undetectable		 2fn1B-1pqzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		5 ILE A 524
GLY A 372
HIS A 371
ARG A 476
GLY A 523
 None
None
G  B  70 ( 4.6A)
G  B  70 ( 4.0A)
None
 1.18A 2fn1B-1qf6A:
undetectable		 2fn1B-1qf6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 ILE A 165
THR A 133
GLU A  55
HIS A 152
GLU A 172
 None
None
None
SAM  A 501 ( 4.9A)
None
 1.36A 2fn1B-1r30A:
undetectable		 2fn1B-1r30A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ILE A 625
GLY A 323
THR A 319
THR A 626
GLY A 624
 None
 1.15A 2fn1B-1xjeA:
undetectable		 2fn1B-1xjeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		5 GLU A 166
GLY A 171
THR A  53
HIS A  31
GLY A 184
 None
 1.19A 2fn1B-2drhA:
undetectable		 2fn1B-2drhA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		5 ILE A  15
GLY B 287
THR B 243
HIS A   9
GLY A  13
 None
 1.17A 2fn1B-2gezA:
undetectable		 2fn1B-2gezA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 ILE A 266
GLY A 237
THR A 233
ARG A 319
GLU A 282
 None
LLP  A  58 ( 4.4A)
None
None
LLP  A  58 ( 3.7A)
 1.35A 2fn1B-2gn1A:
undetectable		 2fn1B-2gn1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 5 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.40A 2fn1B-2iouA:
undetectable		 2fn1B-2iouA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 ILE A 202
GLU A 154
GLY A 171
THR A 170
THR A 199
 None
UD1  A4000 (-2.7A)
UD1  A4000 ( 4.7A)
None
UD1  A4000 (-3.6A)
 1.12A 2fn1B-2oi6A:
undetectable		 2fn1B-2oi6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 ILE A 385
GLY A 343
THR A 294
HIS A  77
GLY A 341
 None
 1.14A 2fn1B-2p9bA:
undetectable		 2fn1B-2p9bA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql8 PUTATIVE REDOX
PROTEIN

(Lactobacillus
paracasei) 		PF02566
(OsmC) 		5 ILE A 116
GLY A  76
GLU A  67
THR A 113
GLU A  60
 None
 1.35A 2fn1B-2ql8A:
undetectable		 2fn1B-2ql8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 GLU A  60
THR A 357
THR A 331
ARG A  62
GLY A 352
 None
 1.41A 2fn1B-2r4jA:
undetectable		 2fn1B-2r4jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 ILE A 109
GLU A 160
HIS A  55
GLY A 107
GLU A 114
 None
HEC  A 401 (-3.5A)
HEC  A 401 (-3.3A)
None
HEC  A 401 (-4.0A)
 1.48A 2fn1B-2vhdA:
undetectable		 2fn1B-2vhdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		5 GLY A  84
THR A  85
GLU A  21
HIS A 116
GLY A  54
 CSO  A 115 ( 4.2A)
None
None
CSO  A 115 ( 3.9A)
None
 1.08A 2fn1B-2vrnA:
undetectable		 2fn1B-2vrnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 128
GLY A 134
THR A 135
GLU A 103
GLU A 251
 None
None
None
GOL  A 770 (-2.9A)
None
 1.15A 2fn1B-2x58A:
undetectable		 2fn1B-2x58A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 GLY A   9
THR A   6
THR A  82
GLY A  65
GLU A  68
 None
None
CL  A1118 ( 4.5A)
None
None
 1.09A 2fn1B-2y78A:
undetectable		 2fn1B-2y78A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 ILE A  15
GLY B 276
THR B 230
HIS A   9
GLY A  13
 None
None
ASP  B 501 ( 3.8A)
None
None
 1.20A 2fn1B-2zalA:
undetectable		 2fn1B-2zalA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 GLY A 185
GLU A 189
ARG A 146
GLY A 218
GLU A 209
 None
 1.40A 2fn1B-2zqqA:
undetectable		 2fn1B-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 ILE A 161
GLY A 185
GLU A 189
GLY A 218
GLU A 209
 None
 1.37A 2fn1B-2zqqA:
undetectable		 2fn1B-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 ILE A 368
HIS A 596
GLY A 367
GLU A 346
LYS A 399
 None
MG  A 701 (-3.3A)
None
MG  A 701 ( 3.9A)
MG  A 701 ( 4.2A)
 1.29A 2fn1B-3ayxA:
undetectable		 2fn1B-3ayxA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		5 ILE A 106
GLU A  16
THR A  39
THR A 103
GLY A  79
 None
 1.40A 2fn1B-3beoA:
undetectable		 2fn1B-3beoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		5 ILE A 567
GLU A 397
GLY A 392
THR A 391
GLU A 210
 None
None
None
None
MG  A 903 ( 4.6A)
 1.25A 2fn1B-3bxzA:
undetectable		 2fn1B-3bxzA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 240
GLY A 257
THR A 258
HIS A 318
ARG A 387
GLY A 403
GLU A 416
LYS A 420
 None
 0.77A 2fn1B-3bzmA:
42.2		 2fn1B-3bzmA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		5 ILE A 212
GLU A 339
GLY A 132
THR A 133
HIS A  55
 None
FE  A 452 ( 2.4A)
None
None
None
 1.48A 2fn1B-3fmqA:
undetectable		 2fn1B-3fmqA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		5 ILE A 150
GLY A  65
GLU A 223
HIS A  66
GLY A 224
 None
 1.30A 2fn1B-3gmiA:
undetectable		 2fn1B-3gmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		5 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
 None
 0.55A 2fn1B-3gseA:
35.3		 2fn1B-3gseA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		5 GLU A 309
GLY A 254
THR A 255
GLU A 246
GLY A 247
 None
 1.41A 2fn1B-3humA:
undetectable		 2fn1B-3humA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7j BETA-LACTAMASE
MB2281C

(Mycobacterium
bovis) 		PF00144
(Beta-lactamase) 		5 ILE A 234
THR A 178
HIS A 174
ARG A  48
GLY A 225
 None
 1.32A 2fn1B-3i7jA:
undetectable		 2fn1B-3i7jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		5 ILE A 158
GLU A 197
GLY A 155
THR A 260
GLY A 157
 None
 1.06A 2fn1B-3io0A:
undetectable		 2fn1B-3io0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 ILE A 321
GLY A 290
THR A 289
GLU A 326
GLY A 322
 None
CD  A 604 (-4.5A)
None
CD  A 604 (-2.5A)
CD  A 604 ( 4.3A)
 1.27A 2fn1B-3kxdA:
undetectable		 2fn1B-3kxdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ILE A  30
GLY A 366
THR A 367
HIS A 364
GLY A  33
 None
 1.32A 2fn1B-3lp8A:
undetectable		 2fn1B-3lp8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ILE B1013
HIS A  44
THR B1011
GLY B1015
GLU A  15
 None
 1.33A 2fn1B-3myrB:
undetectable		 2fn1B-3myrB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ILE A 357
GLY A 319
THR A 271
HIS A  63
GLY A 317
 None
None
None
ZN  A 425 (-3.3A)
None
 1.25A 2fn1B-3n2cA:
undetectable		 2fn1B-3n2cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		5 ILE A  21
GLY A  16
THR A  22
ARG A   3
GLY A 201
 None
 1.19A 2fn1B-3nfbA:
undetectable		 2fn1B-3nfbA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		5 ILE A 194
GLY A 333
THR A 309
GLY A 331
GLU A 313
 None
 1.31A 2fn1B-3nx3A:
undetectable		 2fn1B-3nx3A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		5 ILE X 236
GLU X 190
GLU X 220
GLY X 238
GLU X 240
 None
 1.22A 2fn1B-3o59X:
undetectable		 2fn1B-3o59X:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		7 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.65A 2fn1B-3os6A:
42.0		 2fn1B-3os6A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		9 GLU A 201
GLY A 218
THR A 219
GLU A 244
HIS A 279
THR A 304
ARG A 352
GLU A 382
LYS A 386
 BEZ  A 701 ( 4.3A)
BEZ  A 701 (-3.5A)
BEZ  A 701 (-4.0A)
MG  A 700 ( 2.5A)
BEZ  A 701 (-3.8A)
BEZ  A 701 (-4.7A)
PYR  A 702 ( 3.9A)
MG  A 700 ( 2.5A)
PYR  A 702 ( 3.1A)
 0.39A 2fn1B-3r75A:
43.1		 2fn1B-3r75A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 GLY A 218
THR A 219
HIS A 279
THR A 369
ARG A 352
 BEZ  A 701 (-3.5A)
BEZ  A 701 (-4.0A)
BEZ  A 701 (-3.8A)
BEZ  A 701 (-4.1A)
PYR  A 702 ( 3.9A)
 1.17A 2fn1B-3r75A:
43.1		 2fn1B-3r75A:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ILE A 207
GLU A 252
GLU A 297
THR A 361
GLY A 421
 VAE  A 451 (-4.2A)
None
MG  A 452 (-3.8A)
VAE  A 451 (-4.7A)
VAE  A 451 ( 4.2A)
 1.03A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ILE A 207
GLY A 270
THR A 271
THR A 361
LYS A 438
 VAE  A 451 (-4.2A)
VAE  A 451 ( 3.8A)
VAE  A 451 ( 4.7A)
VAE  A 451 (-4.7A)
VAE  A 451 (-2.8A)
 1.16A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ILE A 207
THR A 271
THR A 361
GLY A 421
LYS A 438
 VAE  A 451 (-4.2A)
VAE  A 451 ( 4.7A)
VAE  A 451 (-4.7A)
VAE  A 451 ( 4.2A)
VAE  A 451 (-2.8A)
 1.12A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ILE A 207
THR A 361
GLY A 421
GLU A 434
LYS A 438
 VAE  A 451 (-4.2A)
VAE  A 451 (-4.7A)
VAE  A 451 ( 4.2A)
MG  A 452 ( 4.9A)
VAE  A 451 (-2.8A)
 0.98A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 5 GLY A 300
GLU A 299
THR A 252
GLY A 227
GLU A 140
 None
 1.31A 2fn1B-3u4gA:
undetectable		 2fn1B-3u4gA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 111
GLY A 135
THR A 136
THR A 112
GLU A 297
 None
 1.06A 2fn1B-3vpxA:
undetectable		 2fn1B-3vpxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 ILE A 105
GLU A 162
GLY A 111
THR A 112
GLY A 115
 None
 1.45A 2fn1B-3wrtA:
undetectable		 2fn1B-3wrtA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 GLY A   9
THR A   6
THR A  82
GLY A  65
GLU A  68
 None
 1.05A 2fn1B-4dz3A:
undetectable		 2fn1B-4dz3A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		5 GLU A 211
GLY A 208
THR A 112
THR A 250
GLY A 314
 None
 1.34A 2fn1B-4eysA:
undetectable		 2fn1B-4eysA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6u EC869 CDIA-CT
EC869 CDII

(Escherichia
coli) 		PF07262
(CdiI)
no annotation 		5 ILE B 112
THR A 252
THR B 120
GLY B 111
GLU A 250
 None
 0.99A 2fn1B-4g6uB:
undetectable		 2fn1B-4g6uB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 389
GLU A 271
GLY A 395
GLY A 391
GLU A 393
 GOL  A 603 ( 4.7A)
GOL  A 603 ( 2.8A)
None
None
None
 1.34A 2fn1B-4ha6A:
undetectable		 2fn1B-4ha6A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 ILE A 226
GLY A 223
THR A 222
THR A 217
GLY A 189
 None
 1.46A 2fn1B-4je5A:
undetectable		 2fn1B-4je5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLU A  14
GLY A  17
THR A  20
GLY A  40
GLU A 220
 MLI  A 502 (-4.7A)
MLI  A 502 (-3.2A)
None
MLI  A 502 (-4.8A)
None
 1.19A 2fn1B-4m9dA:
undetectable		 2fn1B-4m9dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ILE A  37
GLY A  48
GLU A  42
HIS A  51
GLY A  38
 None
 1.42A 2fn1B-4nnzA:
undetectable		 2fn1B-4nnzA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 ILE A  95
GLY A  90
HIS A  50
THR A 118
GLY A 120
 None
 1.37A 2fn1B-4o89A:
undetectable		 2fn1B-4o89A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		5 ILE A 180
GLU A 104
GLY A 130
GLU A 111
GLY A 110
 None
FE  A 501 ( 2.4A)
None
None
None
 1.41A 2fn1B-4p1cA:
undetectable		 2fn1B-4p1cA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		5 ILE A  45
GLU A 222
GLY A  52
HIS A 236
GLY A  44
 None
API  A 510 (-3.6A)
None
None
None
 1.45A 2fn1B-4q6pA:
undetectable		 2fn1B-4q6pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 184
GLY A 114
HIS A 115
THR A 157
GLY A 185
 None
FAD  A 601 (-3.2A)
FAD  A 601 (-2.5A)
None
FAD  A 601 (-3.6A)
 1.23A 2fn1B-4ud8A:
undetectable		 2fn1B-4ud8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLU A 459
GLY A 144
THR A 143
HIS A 145
THR A 246
 None
 1.45A 2fn1B-4yweA:
undetectable		 2fn1B-4yweA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE A 475
GLY A 490
THR A 486
GLU A 421
GLY A 438
 None
None
MCN  A 801 (-3.4A)
None
None
 1.37A 2fn1B-4zohA:
undetectable		 2fn1B-4zohA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		5 ILE A 190
GLU A 362
THR A 116
HIS A 113
GLY A 269
 None
 1.45A 2fn1B-4zxzA:
undetectable		 2fn1B-4zxzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		5 ILE F 118
GLU F 187
GLU F 265
HIS H  52
THR F 152
 None
 1.16A 2fn1B-5a5tF:
undetectable		 2fn1B-5a5tF:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 GLU A 221
GLY A 718
THR A 378
GLY A 716
LYS A 698
 MF4  A2001 (-3.4A)
MG  A2002 ( 4.7A)
MF4  A2001 ( 3.9A)
None
MF4  A2001 (-2.7A)
 1.41A 2fn1B-5aw4A:
undetectable		 2fn1B-5aw4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		5 ILE A  66
GLU A 124
GLY A 142
GLY A  67
GLU A 140
 None
 1.22A 2fn1B-5bwiA:
undetectable		 2fn1B-5bwiA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A 205
GLY A 377
THR A 376
GLU A 384
GLY A 379
 None
 1.48A 2fn1B-5ce6A:
undetectable		 2fn1B-5ce6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		5 ILE A 246
GLU A  95
GLY A  73
THR A  74
GLY A 247
 None
 1.14A 2fn1B-5ctmA:
undetectable		 2fn1B-5ctmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 307
GLY A 324
THR A 325
HIS A 388
THR A 415
 0GA  A 604 ( 4.5A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
 0.56A 2fn1B-5cwaA:
38.1		 2fn1B-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 307
THR A 325
HIS A 388
THR A 415
GLY A 474
 0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
0GA  A 604 ( 4.4A)
 0.95A 2fn1B-5cwaA:
38.1		 2fn1B-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 307
THR A 325
HIS A 388
THR A 415
GLY A 475
 0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
None
 0.54A 2fn1B-5cwaA:
38.1		 2fn1B-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		5 GLY A 167
THR A 166
HIS A 163
THR A 170
GLY A 128
 None
 1.33A 2fn1B-5erpA:
undetectable		 2fn1B-5erpA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 ILE H  41
GLU H  73
GLY H 107
THR H 106
GLY H 102
 None
 1.25A 2fn1B-5fg9H:
undetectable		 2fn1B-5fg9H:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 231
GLY A 255
THR A 299
HIS A 315
GLY A 230
 None
 1.50A 2fn1B-5fp1A:
undetectable		 2fn1B-5fp1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 231
GLY A 255
THR A 299
THR A 252
GLY A 230
 None
 1.42A 2fn1B-5fp1A:
undetectable		 2fn1B-5fp1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		5 GLU A 163
GLY A 140
THR A 129
GLY A 167
GLU A 173
 None
 1.44A 2fn1B-5j1qA:
undetectable		 2fn1B-5j1qA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		7 GLY A 257
THR A 258
GLU A 281
HIS A 321
ARG A 391
GLU A 420
LYS A 424
 ACT  A 503 (-3.2A)
ACT  A 503 (-3.7A)
FE2  A 501 ( 4.1A)
ACT  A 503 ( 4.1A)
ACT  A 502 (-3.5A)
FE2  A 501 ( 2.8A)
ACT  A 503 ( 2.3A)
 1.50A 2fn1B-5jy9A:
70.7		 2fn1B-5jy9A:
99.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		11 ILE A 195
GLU A 240
GLY A 257
THR A 258
GLU A 284
HIS A 321
THR A 348
ARG A 391
GLY A 407
GLU A 420
LYS A 424
 ACT  A 502 ( 4.8A)
None
ACT  A 503 (-3.2A)
ACT  A 503 (-3.7A)
FE2  A 501 ( 2.7A)
ACT  A 503 ( 4.1A)
None
ACT  A 502 (-3.5A)
ACT  A 503 (-3.8A)
FE2  A 501 ( 2.8A)
ACT  A 503 ( 2.3A)
 0.34A 2fn1B-5jy9A:
70.7		 2fn1B-5jy9A:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzd ISOCHORISMATE
SYNTHASE ENTC

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.53A 2fn1B-5jzdA:
40.5		 2fn1B-5jzdA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A 197
GLY A 175
GLU A 156
THR A 198
GLY A 172
 None
 1.42A 2fn1B-5k8bA:
undetectable		 2fn1B-5k8bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 ILE A 247
GLU A 212
GLY A 255
ARG A 471
GLY A 248
 None
 1.47A 2fn1B-5kf7A:
undetectable		 2fn1B-5kf7A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 ILE H 358
GLU H 198
GLY H 342
THR H 361
GLU H 318
 None
 1.46A 2fn1B-5lp7H:
undetectable		 2fn1B-5lp7H:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 ILE A  21
GLY A  16
THR A  22
ARG A   2
GLY A 195
 None
 1.14A 2fn1B-5tzbA:
undetectable		 2fn1B-5tzbA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 ILE A 366
GLU A 415
GLY A 372
GLY A 367
GLU A 368
 None
 1.34A 2fn1B-5ul4A:
undetectable		 2fn1B-5ul4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 5 GLY A   9
THR A   6
THR A  82
GLY A  65
GLU A  68
 None
 1.09A 2fn1B-5v8tA:
undetectable		 2fn1B-5v8tA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 5 GLY A  58
THR A  57
GLU A  62
THR A  31
GLU A  24
 None
 1.19A 2fn1B-5w7kA:
undetectable		 2fn1B-5w7kA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 GLY B 220
THR B 219
THR B 121
ARG B 115
GLY B  93
 FAD  B 601 (-3.1A)
FAD  B 601 (-3.9A)
FAD  B 601 (-3.5A)
FAD  B 601 (-3.1A)
FAD  B 601 (-3.2A)
 1.18A 2fn1B-5x1yB:
undetectable		 2fn1B-5x1yB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 5 ILE A  62
GLY A  97
THR A  96
GLY A 317
GLU A 316
 None
 1.26A 2fn1B-6b5fA:
undetectable		 2fn1B-6b5fA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 GLY A 147
THR A 146
THR A  42
ARG A  36
GLY A  14
 FAD  A 502 (-3.0A)
FAD  A 502 (-4.2A)
FAD  A 502 (-3.5A)
FAD  A 502 (-3.4A)
FAD  A 502 (-3.3A)
 1.17A 2fn1B-6cmzA:
undetectable		 2fn1B-6cmzA:
10.30