SIMILAR PATTERNS OF AMINO ACIDS FOR 2FN1_B_SALB503
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b65 | PROTEIN(AMINOPEPTIDASE) (Ochrobactrumanthropi) |
PF03576(Peptidase_S58) | 5 | GLY A 24THR A 23THR A 30ARG A 11GLY A 212 | None | 1.00A | 2fn1B-1b65A:undetectable | 2fn1B-1b65A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b65 | PROTEIN(AMINOPEPTIDASE) (Ochrobactrumanthropi) |
PF03576(Peptidase_S58) | 5 | ILE A 29GLY A 24THR A 30ARG A 11GLY A 212 | None | 1.07A | 2fn1B-1b65A:undetectable | 2fn1B-1b65A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e2t | N-HYDROXYARYLAMINEO-ACETYLTRANSFERASE (Salmonellaenterica) |
PF00797(Acetyltransf_2) | 5 | ILE A 36GLU A 39HIS A 259GLY A 66GLU A 71 | None | 1.43A | 2fn1B-1e2tA:undetectable | 2fn1B-1e2tA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evl | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon) | 5 | ILE A 524GLY A 372HIS A 371ARG A 476GLY A 523 | None | 1.16A | 2fn1B-1evlA:undetectable | 2fn1B-1evlA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxj | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | ILE A 202GLU A 154GLY A 171THR A 170THR A 199 | ILE A 202 ( 0.7A)GLU A 154 ( 0.6A)GLY A 171 ( 0.0A)THR A 170 ( 0.8A)THR A 199 ( 0.8A) | 1.23A | 2fn1B-1fxjA:undetectable | 2fn1B-1fxjA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 10 | GLU A 309GLY A 328THR A 329GLU A 361HIS A 398THR A 425ARG A 469GLY A 485GLU A 498LYS A 502 | BEZ A1501 (-3.8A)BEZ A1501 (-3.3A)BEZ A1501 (-3.9A) MG A1701 ( 3.1A)BEZ A1501 ( 4.2A)BEZ A1501 (-4.7A)PYR A1601 ( 3.9A)BEZ A1501 (-3.8A) MG A1701 ( 2.6A)BEZ A1501 ( 2.9A) | 0.41A | 2fn1B-1i7qA:41.7 | 2fn1B-1i7qA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 309THR A 329HIS A 398GLY A 483GLU A 498 | BEZ A1501 (-3.8A)BEZ A1501 (-3.9A)BEZ A1501 ( 4.2A)PYR A1601 (-3.8A) MG A1701 ( 2.6A) | 1.36A | 2fn1B-1i7qA:41.7 | 2fn1B-1i7qA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | ANTHRANILATESYNTHASE (Serratiamarcescens) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 7 | GLY A 328THR A 329GLU A 358HIS A 398ARG A 469GLU A 498LYS A 502 | BEZ A1501 (-3.3A)BEZ A1501 (-3.9A) MG A1701 ( 4.3A)BEZ A1501 ( 4.2A)PYR A1601 ( 3.9A) MG A1701 ( 2.6A)BEZ A1501 ( 2.9A) | 1.39A | 2fn1B-1i7qA:41.7 | 2fn1B-1i7qA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1in8 | HOLLIDAY JUNCTIONDNA HELICASE RUVB (Thermotogamaritima) |
PF05491(RuvB_C)PF05496(RuvB_N) | 5 | ILE A 268GLU A 298GLY A 313THR A 310GLY A 275 | None | 1.14A | 2fn1B-1in8A:undetectable | 2fn1B-1in8A:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0g | P-AMINOBENZOATESYNTHASE COMPONENT I (Escherichiacoli) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 258ARG A 410GLY A 426GLU A 439LYS A 443 | None | 1.05A | 2fn1B-1k0gA:36.6 | 2fn1B-1k0gA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kv9 | TYPE IIQUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 5 | ILE A 154GLY A 112HIS A 21THR A 155GLY A 123 | NoneNoneNonePQQ A 801 (-2.8A)None | 1.30A | 2fn1B-1kv9A:undetectable | 2fn1B-1kv9A:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwm | PROCARBOXYPEPTIDASEB (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | GLU A 163GLY A 140THR A 129GLY A 167GLU A 173 | None | 1.41A | 2fn1B-1kwmA:undetectable | 2fn1B-1kwmA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nsa | PROCARBOXYPEPTIDASEB (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | GLU A 163GLY A 140THR A 129GLY A 167GLU A 173 | None | 1.43A | 2fn1B-1nsaA:undetectable | 2fn1B-1nsaA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqz | MCMV M144 (Muridbetaherpesvirus1) |
PF07654(C1-set) | 5 | GLU A 36GLY A 31THR A 30HIS A 32GLY A 48 | None | 1.42A | 2fn1B-1pqzA:undetectable | 2fn1B-1pqzA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qf6 | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF00587(tRNA-synt_2b)PF02824(TGS)PF03129(HGTP_anticodon)PF07973(tRNA_SAD) | 5 | ILE A 524GLY A 372HIS A 371ARG A 476GLY A 523 | NoneNone G B 70 ( 4.6A) G B 70 ( 4.0A)None | 1.18A | 2fn1B-1qf6A:undetectable | 2fn1B-1qf6A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r30 | BIOTIN SYNTHASE (Escherichiacoli) |
PF04055(Radical_SAM)PF06968(BATS) | 5 | ILE A 165THR A 133GLU A 55HIS A 152GLU A 172 | NoneNoneNoneSAM A 501 ( 4.9A)None | 1.36A | 2fn1B-1r30A:undetectable | 2fn1B-1r30A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xje | RIBONUCLEOTIDEREDUCTASE,B12-DEPENDENT (Thermotogamaritima) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC) | 5 | ILE A 625GLY A 323THR A 319THR A 626GLY A 624 | None | 1.15A | 2fn1B-1xjeA:undetectable | 2fn1B-1xjeA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2drh | 361AA LONGHYPOTHETICALD-AMINOPEPTIDASE (Pyrococcushorikoshii) |
PF03576(Peptidase_S58) | 5 | GLU A 166GLY A 171THR A 53HIS A 31GLY A 184 | None | 1.19A | 2fn1B-2drhA:undetectable | 2fn1B-2drhA:23.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gez | L-ASPARAGINASE ALPHASUBUNITL-ASPARAGINASE BETASUBUNIT (Lupinus luteus) |
PF01112(Asparaginase_2) | 5 | ILE A 15GLY B 287THR B 243HIS A 9GLY A 13 | None | 1.17A | 2fn1B-2gezA:undetectable | 2fn1B-2gezA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gn1 | THREONINEDEHYDRATASECATABOLIC (Salmonellaenterica) |
PF00291(PALP) | 5 | ILE A 266GLY A 237THR A 233ARG A 319GLU A 282 | NoneLLP A 58 ( 4.4A)NoneNoneLLP A 58 ( 3.7A) | 1.35A | 2fn1B-2gn1A:undetectable | 2fn1B-2gn1A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iou | MAJOR TROPISMDETERMINANT P1 (Bordetellavirus BPP1) |
no annotation | 5 | GLY A 204THR A 205HIS A 248GLY A 181LYS A 250 | None | 1.40A | 2fn1B-2iouA:undetectable | 2fn1B-2iouA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oi6 | BIFUNCTIONAL PROTEINGLMU (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | ILE A 202GLU A 154GLY A 171THR A 170THR A 199 | NoneUD1 A4000 (-2.7A)UD1 A4000 ( 4.7A)NoneUD1 A4000 (-3.6A) | 1.12A | 2fn1B-2oi6A:undetectable | 2fn1B-2oi6A:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p9b | POSSIBLE PROLIDASE (Bifidobacteriumlongum) |
PF01979(Amidohydro_1) | 5 | ILE A 385GLY A 343THR A 294HIS A 77GLY A 341 | None | 1.14A | 2fn1B-2p9bA:undetectable | 2fn1B-2p9bA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ql8 | PUTATIVE REDOXPROTEIN (Lactobacillusparacasei) |
PF02566(OsmC) | 5 | ILE A 116GLY A 76GLU A 67THR A 113GLU A 60 | None | 1.35A | 2fn1B-2ql8A:undetectable | 2fn1B-2ql8A:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4j | AEROBICGLYCEROL-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF01266(DAO)PF16901(DAO_C) | 5 | GLU A 60THR A 357THR A 331ARG A 62GLY A 352 | None | 1.41A | 2fn1B-2r4jA:undetectable | 2fn1B-2r4jA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhd | CYTOCHROME C551PEROXIDASE (Pseudomonasaeruginosa) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 5 | ILE A 109GLU A 160HIS A 55GLY A 107GLU A 114 | NoneHEC A 401 (-3.5A)HEC A 401 (-3.3A)NoneHEC A 401 (-4.0A) | 1.48A | 2fn1B-2vhdA:undetectable | 2fn1B-2vhdA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrn | PROTEASE I (Deinococcusradiodurans) |
PF01965(DJ-1_PfpI) | 5 | GLY A 84THR A 85GLU A 21HIS A 116GLY A 54 | CSO A 115 ( 4.2A)NoneNoneCSO A 115 ( 3.9A)None | 1.08A | 2fn1B-2vrnA:undetectable | 2fn1B-2vrnA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x58 | PEROXISOMALBIFUNCTIONAL ENZYME (Rattusnorvegicus) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 128GLY A 134THR A 135GLU A 103GLU A 251 | NoneNoneNoneGOL A 770 (-2.9A)None | 1.15A | 2fn1B-2x58A:undetectable | 2fn1B-2x58A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y78 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 5 | GLY A 9THR A 6THR A 82GLY A 65GLU A 68 | NoneNone CL A1118 ( 4.5A)NoneNone | 1.09A | 2fn1B-2y78A:undetectable | 2fn1B-2y78A:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zal | L-ASPARAGINASE (Escherichiacoli) |
PF01112(Asparaginase_2) | 5 | ILE A 15GLY B 276THR B 230HIS A 9GLY A 13 | NoneNoneASP B 501 ( 3.8A)NoneNone | 1.20A | 2fn1B-2zalA:undetectable | 2fn1B-2zalA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zqq | METHYLGLUTACONYL-COAHYDRATASE (Homo sapiens) |
PF00378(ECH_1) | 5 | GLY A 185GLU A 189ARG A 146GLY A 218GLU A 209 | None | 1.40A | 2fn1B-2zqqA:undetectable | 2fn1B-2zqqA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zqq | METHYLGLUTACONYL-COAHYDRATASE (Homo sapiens) |
PF00378(ECH_1) | 5 | ILE A 161GLY A 185GLU A 189GLY A 218GLU A 209 | None | 1.37A | 2fn1B-2zqqA:undetectable | 2fn1B-2zqqA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 5 | ILE A 368HIS A 596GLY A 367GLU A 346LYS A 399 | None MG A 701 (-3.3A)None MG A 701 ( 3.9A) MG A 701 ( 4.2A) | 1.29A | 2fn1B-3ayxA:undetectable | 2fn1B-3ayxA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beo | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillusanthracis) |
PF02350(Epimerase_2) | 5 | ILE A 106GLU A 16THR A 39THR A 103GLY A 79 | None | 1.40A | 2fn1B-3beoA:undetectable | 2fn1B-3beoA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxz | PREPROTEINTRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF07517(SecA_DEAD) | 5 | ILE A 567GLU A 397GLY A 392THR A 391GLU A 210 | NoneNoneNoneNone MG A 903 ( 4.6A) | 1.25A | 2fn1B-3bxzA:undetectable | 2fn1B-3bxzA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bzm | MENAQUINONE-SPECIFICISOCHORISMATESYNTHASE (Escherichiacoli) |
PF00425(Chorismate_bind) | 8 | GLU A 240GLY A 257THR A 258HIS A 318ARG A 387GLY A 403GLU A 416LYS A 420 | None | 0.77A | 2fn1B-3bzmA:42.2 | 2fn1B-3bzmA:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmq | METHIONINEAMINOPEPTIDASE 2 (Encephalitozooncuniculi) |
PF00557(Peptidase_M24) | 5 | ILE A 212GLU A 339GLY A 132THR A 133HIS A 55 | None FE A 452 ( 2.4A)NoneNoneNone | 1.48A | 2fn1B-3fmqA:undetectable | 2fn1B-3fmqA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmi | UPF0348 PROTEINMJ0951 (Methanocaldococcusjannaschii) |
PF05636(HIGH_NTase1)PF16581(HIGH_NTase1_ass) | 5 | ILE A 150GLY A 65GLU A 223HIS A 66GLY A 224 | None | 1.30A | 2fn1B-3gmiA:undetectable | 2fn1B-3gmiA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gse | MENAQUINONE-SPECIFICISOCHORISMATESYNTHASE (Yersinia pestis) |
PF00425(Chorismate_bind) | 5 | GLU A 258GLY A 275THR A 276GLU A 302HIS A 336 | None | 0.55A | 2fn1B-3gseA:35.3 | 2fn1B-3gseA:27.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hum | PENICILLIN-BINDINGPROTEIN 4 (Staphylococcusaureus) |
PF00768(Peptidase_S11)PF09211(DUF1958) | 5 | GLU A 309GLY A 254THR A 255GLU A 246GLY A 247 | None | 1.41A | 2fn1B-3humA:undetectable | 2fn1B-3humA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i7j | BETA-LACTAMASEMB2281C (Mycobacteriumbovis) |
PF00144(Beta-lactamase) | 5 | ILE A 234THR A 178HIS A 174ARG A 48GLY A 225 | None | 1.32A | 2fn1B-3i7jA:undetectable | 2fn1B-3i7jA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3io0 | ETUB PROTEIN (Clostridiumkluyveri) |
PF00936(BMC) | 5 | ILE A 158GLU A 197GLY A 155THR A 260GLY A 157 | None | 1.06A | 2fn1B-3io0A:undetectable | 2fn1B-3io0A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kxd | CALCIUM-GATEDPOTASSIUM CHANNELMTHK (Methanothermobacterthermautotrophicus) |
PF02080(TrkA_C)PF02254(TrkA_N) | 5 | ILE A 321GLY A 290THR A 289GLU A 326GLY A 322 | None CD A 604 (-4.5A)None CD A 604 (-2.5A) CD A 604 ( 4.3A) | 1.27A | 2fn1B-3kxdA:undetectable | 2fn1B-3kxdA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lp8 | PHOSPHORIBOSYLAMINE-GLYCINE LIGASE (Ehrlichiachaffeensis) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | ILE A 30GLY A 366THR A 367HIS A 364GLY A 33 | None | 1.32A | 2fn1B-3lp8A:undetectable | 2fn1B-3lp8A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myr | HYDROGENASE (NIFE)SMALL SUBUNIT HYDANICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Allochromatiumvinosum) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | ILE B1013HIS A 44THR B1011GLY B1015GLU A 15 | None | 1.33A | 2fn1B-3myrB:undetectable | 2fn1B-3myrB:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2c | PROLIDASE (unidentified) |
PF01979(Amidohydro_1) | 5 | ILE A 357GLY A 319THR A 271HIS A 63GLY A 317 | NoneNoneNone ZN A 425 (-3.3A)None | 1.25A | 2fn1B-3n2cA:undetectable | 2fn1B-3n2cA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nfb | BETA-PEPTIDYLAMINOPEPTIDASE (Sphingosinicellaxenopeptidilytica) |
PF03576(Peptidase_S58) | 5 | ILE A 21GLY A 16THR A 22ARG A 3GLY A 201 | None | 1.19A | 2fn1B-3nfbA:undetectable | 2fn1B-3nfbA:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx3 | ACETYLORNITHINEAMINOTRANSFERASE (Campylobacterjejuni) |
PF00202(Aminotran_3) | 5 | ILE A 194GLY A 333THR A 309GLY A 331GLU A 313 | None | 1.31A | 2fn1B-3nx3A:undetectable | 2fn1B-3nx3A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o59 | DNA POLYMERASE IILARGE SUBUNIT (Pyrococcushorikoshii) |
PF03833(PolC_DP2) | 5 | ILE X 236GLU X 190GLU X 220GLY X 238GLU X 240 | None | 1.22A | 2fn1B-3o59X:undetectable | 2fn1B-3o59X:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os6 | ISOCHORISMATESYNTHASE DHBC (Bacillusanthracis) |
PF00425(Chorismate_bind) | 7 | GLU A 197GLY A 214HIS A 276ARG A 348GLY A 364GLU A 377LYS A 381 | NoneSO4 A 404 (-3.8A)NoneNoneSO4 A 404 (-3.8A)SO4 A 404 (-4.1A)SO4 A 404 (-2.9A) | 0.65A | 2fn1B-3os6A:42.0 | 2fn1B-3os6A:26.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 9 | GLU A 201GLY A 218THR A 219GLU A 244HIS A 279THR A 304ARG A 352GLU A 382LYS A 386 | BEZ A 701 ( 4.3A)BEZ A 701 (-3.5A)BEZ A 701 (-4.0A) MG A 700 ( 2.5A)BEZ A 701 (-3.8A)BEZ A 701 (-4.7A)PYR A 702 ( 3.9A) MG A 700 ( 2.5A)PYR A 702 ( 3.1A) | 0.39A | 2fn1B-3r75A:43.1 | 2fn1B-3r75A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 5 | GLY A 218THR A 219HIS A 279THR A 369ARG A 352 | BEZ A 701 (-3.5A)BEZ A 701 (-4.0A)BEZ A 701 (-3.8A)BEZ A 701 (-4.1A)PYR A 702 ( 3.9A) | 1.17A | 2fn1B-3r75A:43.1 | 2fn1B-3r75A:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | ILE A 207GLU A 252GLU A 297THR A 361GLY A 421 | VAE A 451 (-4.2A)None MG A 452 (-3.8A)VAE A 451 (-4.7A)VAE A 451 ( 4.2A) | 1.03A | 2fn1B-3rv6A:48.3 | 2fn1B-3rv6A:37.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | ILE A 207GLY A 270THR A 271THR A 361LYS A 438 | VAE A 451 (-4.2A)VAE A 451 ( 3.8A)VAE A 451 ( 4.7A)VAE A 451 (-4.7A)VAE A 451 (-2.8A) | 1.16A | 2fn1B-3rv6A:48.3 | 2fn1B-3rv6A:37.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | ILE A 207THR A 271THR A 361GLY A 421LYS A 438 | VAE A 451 (-4.2A)VAE A 451 ( 4.7A)VAE A 451 (-4.7A)VAE A 451 ( 4.2A)VAE A 451 (-2.8A) | 1.12A | 2fn1B-3rv6A:48.3 | 2fn1B-3rv6A:37.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | ILE A 207THR A 361GLY A 421GLU A 434LYS A 438 | VAE A 451 (-4.2A)VAE A 451 (-4.7A)VAE A 451 ( 4.2A) MG A 452 ( 4.9A)VAE A 451 (-2.8A) | 0.98A | 2fn1B-3rv6A:48.3 | 2fn1B-3rv6A:37.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 5 | GLY A 300GLU A 299THR A 252GLY A 227GLU A 140 | None | 1.31A | 2fn1B-3u4gA:undetectable | 2fn1B-3u4gA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpx | LEUCINEDEHYDROGENASE (Sporosarcinapsychrophila) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | ILE A 111GLY A 135THR A 136THR A 112GLU A 297 | None | 1.06A | 2fn1B-3vpxA:undetectable | 2fn1B-3vpxA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrt | BETA-LACTAMASE (Chromohalobactersp. 560) |
PF00144(Beta-lactamase) | 5 | ILE A 105GLU A 162GLY A 111THR A 112GLY A 115 | None | 1.45A | 2fn1B-3wrtA:undetectable | 2fn1B-3wrtA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dz3 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 5 | GLY A 9THR A 6THR A 82GLY A 65GLU A 68 | None | 1.05A | 2fn1B-4dz3A:undetectable | 2fn1B-4dz3A:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eys | MCCC FAMILY PROTEIN (Streptococcuspneumoniae) |
PF02016(Peptidase_S66) | 5 | GLU A 211GLY A 208THR A 112THR A 250GLY A 314 | None | 1.34A | 2fn1B-4eysA:undetectable | 2fn1B-4eysA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6u | EC869 CDIA-CTEC869 CDII (Escherichiacoli) |
PF07262(CdiI)no annotation | 5 | ILE B 112THR A 252THR B 120GLY B 111GLU A 250 | None | 0.99A | 2fn1B-4g6uB:undetectable | 2fn1B-4g6uB:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha6 | PYRIDOXINE 4-OXIDASE (Mesorhizobiumloti) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ILE A 389GLU A 271GLY A 395GLY A 391GLU A 393 | GOL A 603 ( 4.7A)GOL A 603 ( 2.8A)NoneNoneNone | 1.34A | 2fn1B-4ha6A:undetectable | 2fn1B-4ha6A:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4je5 | AROMATIC/AMINOADIPATE AMINOTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 5 | ILE A 226GLY A 223THR A 222THR A 217GLY A 189 | None | 1.46A | 2fn1B-4je5A:undetectable | 2fn1B-4je5A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9d | ADENYLOSUCCINATESYNTHETASE (Bacillusanthracis) |
PF00709(Adenylsucc_synt) | 5 | GLU A 14GLY A 17THR A 20GLY A 40GLU A 220 | MLI A 502 (-4.7A)MLI A 502 (-3.2A)NoneMLI A 502 (-4.8A)None | 1.19A | 2fn1B-4m9dA:undetectable | 2fn1B-4m9dA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnz | PROBABLE ZINCPROTEASE (Pseudomonasaeruginosa) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | ILE A 37GLY A 48GLU A 42HIS A 51GLY A 38 | None | 1.42A | 2fn1B-4nnzA:undetectable | 2fn1B-4nnzA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o89 | RNA 3'-TERMINALPHOSPHATE CYCLASE (Pyrococcushorikoshii) |
PF01137(RTC)PF05189(RTC_insert) | 5 | ILE A 95GLY A 90HIS A 50THR A 118GLY A 120 | None | 1.37A | 2fn1B-4o89A:undetectable | 2fn1B-4o89A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1c | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonasmendocina) |
PF02332(Phenol_Hydrox) | 5 | ILE A 180GLU A 104GLY A 130GLU A 111GLY A 110 | None FE A 501 ( 2.4A)NoneNoneNone | 1.41A | 2fn1B-4p1cA:undetectable | 2fn1B-4p1cA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6p | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF17033(Peptidase_M99)PF17129(Peptidase_M99_C)PF17130(Peptidase_M99_m) | 5 | ILE A 45GLU A 222GLY A 52HIS A 236GLY A 44 | NoneAPI A 510 (-3.6A)NoneNoneNone | 1.45A | 2fn1B-4q6pA:undetectable | 2fn1B-4q6pA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | ILE A 184GLY A 114HIS A 115THR A 157GLY A 185 | NoneFAD A 601 (-3.2A)FAD A 601 (-2.5A)NoneFAD A 601 (-3.6A) | 1.23A | 2fn1B-4ud8A:undetectable | 2fn1B-4ud8A:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywe | PUTATIVE ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 5 | GLU A 459GLY A 144THR A 143HIS A 145THR A 246 | None | 1.45A | 2fn1B-4yweA:undetectable | 2fn1B-4yweA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEMOLYBDOPTERIN-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 5 | ILE A 475GLY A 490THR A 486GLU A 421GLY A 438 | NoneNoneMCN A 801 (-3.4A)NoneNone | 1.37A | 2fn1B-4zohA:undetectable | 2fn1B-4zohA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxz | LEVOGLUCOSAN KINASE (Lipomycesstarkeyi) |
PF03702(AnmK) | 5 | ILE A 190GLU A 362THR A 116HIS A 113GLY A 269 | None | 1.45A | 2fn1B-4zxzA:undetectable | 2fn1B-4zxzA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5t | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT FEUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT H (Oryctolaguscuniculus) |
PF01398(JAB)PF13012(MitMem_reg) | 5 | ILE F 118GLU F 187GLU F 265HIS H 52THR F 152 | None | 1.16A | 2fn1B-5a5tF:undetectable | 2fn1B-5a5tF:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aw4 | NA, K-ATPASE ALPHASUBUNIT (Squalusacanthias) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | GLU A 221GLY A 718THR A 378GLY A 716LYS A 698 | MF4 A2001 (-3.4A) MG A2002 ( 4.7A)MF4 A2001 ( 3.9A)NoneMF4 A2001 (-2.7A) | 1.41A | 2fn1B-5aw4A:undetectable | 2fn1B-5aw4A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwi | GLYCOSIDE HYDROLASEFAMILY 79 (Burkholderiapseudomallei) |
PF12891(Glyco_hydro_44) | 5 | ILE A 66GLU A 124GLY A 142GLY A 67GLU A 140 | None | 1.22A | 2fn1B-5bwiA:undetectable | 2fn1B-5bwiA:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ce6 | FACT-SPT16 (Cicer arietinum) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 5 | ILE A 205GLY A 377THR A 376GLU A 384GLY A 379 | None | 1.48A | 2fn1B-5ce6A:undetectable | 2fn1B-5ce6A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ctm | BETA-LACTAMASE (Bacilluspumilus) |
PF00905(Transpeptidase) | 5 | ILE A 246GLU A 95GLY A 73THR A 74GLY A 247 | None | 1.14A | 2fn1B-5ctmA:undetectable | 2fn1B-5ctmA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 307GLY A 324THR A 325HIS A 388THR A 415 | 0GA A 604 ( 4.5A)None0GA A 604 ( 4.6A)0GA A 604 ( 4.3A)None | 0.56A | 2fn1B-5cwaA:38.1 | 2fn1B-5cwaA:28.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 307THR A 325HIS A 388THR A 415GLY A 474 | 0GA A 604 ( 4.5A)0GA A 604 ( 4.6A)0GA A 604 ( 4.3A)None0GA A 604 ( 4.4A) | 0.95A | 2fn1B-5cwaA:38.1 | 2fn1B-5cwaA:28.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwa | ANTHRANILATESYNTHASE COMPONENT 1 (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | GLU A 307THR A 325HIS A 388THR A 415GLY A 475 | 0GA A 604 ( 4.5A)0GA A 604 ( 4.6A)0GA A 604 ( 4.3A)NoneNone | 0.54A | 2fn1B-5cwaA:38.1 | 2fn1B-5cwaA:28.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erp | DESMOCOLLIN-2 (Homo sapiens) |
PF00028(Cadherin) | 5 | GLY A 167THR A 166HIS A 163THR A 170GLY A 128 | None | 1.33A | 2fn1B-5erpA:undetectable | 2fn1B-5erpA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fg9 | PROTEASOME SUBUNITBETA TYPE-2 (Saccharomycescerevisiae) |
PF00227(Proteasome)PF12465(Pr_beta_C) | 5 | ILE H 41GLU H 73GLY H 107THR H 106GLY H 102 | None | 1.25A | 2fn1B-5fg9H:undetectable | 2fn1B-5fg9H:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp1 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ILE A 231GLY A 255THR A 299HIS A 315GLY A 230 | None | 1.50A | 2fn1B-5fp1A:undetectable | 2fn1B-5fp1A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp1 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ILE A 231GLY A 255THR A 299THR A 252GLY A 230 | None | 1.42A | 2fn1B-5fp1A:undetectable | 2fn1B-5fp1A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1q | CARBOXYPEPTIDASE B (Sus scrofa) |
PF00246(Peptidase_M14) | 5 | GLU A 163GLY A 140THR A 129GLY A 167GLU A 173 | None | 1.44A | 2fn1B-5j1qA:undetectable | 2fn1B-5j1qA:22.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jy9 | PUTATIVE SALICYLATESYNTHETASE (Yersiniaenterocolitica) |
PF00425(Chorismate_bind) | 7 | GLY A 257THR A 258GLU A 281HIS A 321ARG A 391GLU A 420LYS A 424 | ACT A 503 (-3.2A)ACT A 503 (-3.7A)FE2 A 501 ( 4.1A)ACT A 503 ( 4.1A)ACT A 502 (-3.5A)FE2 A 501 ( 2.8A)ACT A 503 ( 2.3A) | 1.50A | 2fn1B-5jy9A:70.7 | 2fn1B-5jy9A:99.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5jy9 | PUTATIVE SALICYLATESYNTHETASE (Yersiniaenterocolitica) |
PF00425(Chorismate_bind) | 11 | ILE A 195GLU A 240GLY A 257THR A 258GLU A 284HIS A 321THR A 348ARG A 391GLY A 407GLU A 420LYS A 424 | ACT A 502 ( 4.8A)NoneACT A 503 (-3.2A)ACT A 503 (-3.7A)FE2 A 501 ( 2.7A)ACT A 503 ( 4.1A)NoneACT A 502 (-3.5A)ACT A 503 (-3.8A)FE2 A 501 ( 2.8A)ACT A 503 ( 2.3A) | 0.34A | 2fn1B-5jy9A:70.7 | 2fn1B-5jy9A:99.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jzd | ISOCHORISMATESYNTHASE ENTC (Escherichiacoli) |
PF00425(Chorismate_bind) | 8 | GLU A 197GLY A 214GLU A 241HIS A 276ARG A 347GLY A 363GLU A 376LYS A 380 | ISC A 401 (-3.0A)ISC A 401 (-3.2A) MG A 402 ( 2.4A)ISC A 401 (-3.5A)ISC A 401 (-3.5A)ISC A 401 (-3.3A) MG A 402 ( 2.6A)ISC A 401 (-3.0A) | 0.53A | 2fn1B-5jzdA:40.5 | 2fn1B-5jzdA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8b | 8-AMINO-3,8-DIDEOXY-ALPHA-D-MANNO-OCTULOSONATE TRANSAMINASE (Shewanellaoneidensis) |
PF01041(DegT_DnrJ_EryC1) | 5 | ILE A 197GLY A 175GLU A 156THR A 198GLY A 172 | None | 1.42A | 2fn1B-5k8bA:undetectable | 2fn1B-5k8bA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kf7 | BIFUNCTIONAL PROTEINPUTA (Sinorhizobiummeliloti) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 5 | ILE A 247GLU A 212GLY A 255ARG A 471GLY A 248 | None | 1.47A | 2fn1B-5kf7A:undetectable | 2fn1B-5kf7A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp7 | ACETYL-COAACETYLTRANSFERASE (Bacillussubtilis) |
no annotation | 5 | ILE H 358GLU H 198GLY H 342THR H 361GLU H 318 | None | 1.46A | 2fn1B-5lp7H:undetectable | 2fn1B-5lp7H:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tzb | D-AMINOPEPTIDASE (Burkholderiasp. LK4) |
PF03576(Peptidase_S58) | 5 | ILE A 21GLY A 16THR A 22ARG A 2GLY A 195 | None | 1.14A | 2fn1B-5tzbA:undetectable | 2fn1B-5tzbA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ul4 | OXSB PROTEIN (Bacillusmegaterium) |
PF02310(B12-binding) | 5 | ILE A 366GLU A 415GLY A 372GLY A 367GLU A 368 | None | 1.34A | 2fn1B-5ul4A:undetectable | 2fn1B-5ul4A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8t | UBIQUITIN-LIKEPROTEINSMT3,PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei;Saccharomycescerevisiae) |
no annotation | 5 | GLY A 9THR A 6THR A 82GLY A 65GLU A 68 | None | 1.09A | 2fn1B-5v8tA:undetectable | 2fn1B-5v8tA:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7k | OXAG (Penicilliumoxalicum) |
no annotation | 5 | GLY A 58THR A 57GLU A 62THR A 31GLU A 24 | None | 1.19A | 2fn1B-5w7kA:undetectable | 2fn1B-5w7kA:10.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1y | MERCURIC REDUCTASE (Lysinibacillussphaericus) |
no annotation | 5 | GLY B 220THR B 219THR B 121ARG B 115GLY B 93 | FAD B 601 (-3.1A)FAD B 601 (-3.9A)FAD B 601 (-3.5A)FAD B 601 (-3.1A)FAD B 601 (-3.2A) | 1.18A | 2fn1B-5x1yB:undetectable | 2fn1B-5x1yB:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5f | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Yersiniaenterocolitica) |
no annotation | 5 | ILE A 62GLY A 97THR A 96GLY A 317GLU A 316 | None | 1.26A | 2fn1B-6b5fA:undetectable | 2fn1B-6b5fA:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmz | DIHYDROLIPOYLDEHYDROGENASE (Burkholderiacenocepacia) |
no annotation | 5 | GLY A 147THR A 146THR A 42ARG A 36GLY A 14 | FAD A 502 (-3.0A)FAD A 502 (-4.2A)FAD A 502 (-3.5A)FAD A 502 (-3.4A)FAD A 502 (-3.3A) | 1.17A | 2fn1B-6cmzA:undetectable | 2fn1B-6cmzA:10.30 |