SIMILAR PATTERNS OF AMINO ACIDS FOR 2FN1_A_SALA506_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ILE C 214
GLY C 157
THR C 171
LEU C 181
GLY C 215
 None
 1.41A 2fn1A-1a5lC:
undetectable		 2fn1A-1a5lC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		5 ILE A  36
GLU A  39
HIS A 259
GLY A  66
GLU A  71
 None
 1.42A 2fn1A-1e2tA:
undetectable		 2fn1A-1e2tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ILE A 284
GLY A 290
THR A 291
LEU A 356
GLY A 285
 None
None
None
None
SO4  A 600 (-3.4A)
 1.33A 2fn1A-1eepA:
undetectable		 2fn1A-1eepA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ILE A 524
GLY A 372
HIS A 371
ARG A 476
GLY A 523
 None
 1.20A 2fn1A-1evlA:
undetectable		 2fn1A-1evlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A  29
GLY A 105
LEU A 246
GLY A  31
GLU A  55
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-2.6A)
 1.19A 2fn1A-1gpeA:
undetectable		 2fn1A-1gpeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 GLY A 201
THR A 200
HIS A 202
LEU A 216
GLY A 228
 None
 1.18A 2fn1A-1h7zA:
undetectable		 2fn1A-1h7zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		5 ILE A  33
GLY A  42
HIS A  39
LEU A 233
GLY A  11
 None
FAD  A 579 (-3.2A)
None
None
FAD  A 579 (-3.1A)
 1.42A 2fn1A-1h81A:
undetectable		 2fn1A-1h81A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		9 GLU A 309
GLY A 328
THR A 329
GLU A 361
HIS A 398
ARG A 469
GLY A 485
GLU A 498
LYS A 502
 BEZ  A1501 (-3.8A)
BEZ  A1501 (-3.3A)
BEZ  A1501 (-3.9A)
MG  A1701 ( 3.1A)
BEZ  A1501 ( 4.2A)
PYR  A1601 ( 3.9A)
BEZ  A1501 (-3.8A)
MG  A1701 ( 2.6A)
BEZ  A1501 ( 2.9A)
 0.31A 2fn1A-1i7qA:
42.3		 2fn1A-1i7qA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 309
THR A 329
HIS A 398
GLY A 483
GLU A 498
 BEZ  A1501 (-3.8A)
BEZ  A1501 (-3.9A)
BEZ  A1501 ( 4.2A)
PYR  A1601 (-3.8A)
MG  A1701 ( 2.6A)
 1.35A 2fn1A-1i7qA:
42.3		 2fn1A-1i7qA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		7 GLY A 328
THR A 329
GLU A 358
HIS A 398
ARG A 469
GLU A 498
LYS A 502
 BEZ  A1501 (-3.3A)
BEZ  A1501 (-3.9A)
MG  A1701 ( 4.3A)
BEZ  A1501 ( 4.2A)
PYR  A1601 ( 3.9A)
MG  A1701 ( 2.6A)
BEZ  A1501 ( 2.9A)
 1.45A 2fn1A-1i7qA:
42.3		 2fn1A-1i7qA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 ILE A 268
GLU A 298
GLY A 313
THR A 310
GLY A 275
 None
 1.15A 2fn1A-1in8A:
undetectable		 2fn1A-1in8A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 258
ARG A 410
GLY A 426
GLU A 439
LYS A 443
 None
 1.04A 2fn1A-1k0gA:
36.9		 2fn1A-1k0gA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqz MCMV M144

(Murid
betaherpesvirus
1) 		PF07654
(C1-set) 		5 GLU A  36
GLY A  31
THR A  30
HIS A  32
GLY A  48
 None
 1.42A 2fn1A-1pqzA:
undetectable		 2fn1A-1pqzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		5 ILE A 524
GLY A 372
HIS A 371
ARG A 476
GLY A 523
 None
None
G  B  70 ( 4.6A)
G  B  70 ( 4.0A)
None
 1.21A 2fn1A-1qf6A:
undetectable		 2fn1A-1qf6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 ILE A 165
THR A 133
GLU A  55
HIS A 152
GLU A 172
 None
None
None
SAM  A 501 ( 4.9A)
None
 1.34A 2fn1A-1r30A:
undetectable		 2fn1A-1r30A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shz GUANINE
NUCLEOTIDE-BINDING
PROTEIN
GALPHA(13):GALPHA(I1
) CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00503
(G-alpha) 		5 ILE A 206
GLY A 225
GLU A 229
LEU A  52
GLY A 205
 None
ALF  A 378 (-3.2A)
None
None
None
 1.17A 2fn1A-1shzA:
undetectable		 2fn1A-1shzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		5 GLU B 257
GLY B 228
THR B 227
LEU B 221
GLY B 200
 None
 1.05A 2fn1A-1ta3B:
undetectable		 2fn1A-1ta3B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 ILE A 224
GLY A 142
THR A 109
LEU A 105
GLY A 139
 None
 1.21A 2fn1A-1to6A:
undetectable		 2fn1A-1to6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		5 ILE A  58
GLU A 374
THR A 421
LEU A 373
GLY A 380
 None
 1.33A 2fn1A-1x0mA:
undetectable		 2fn1A-1x0mA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		5 ILE A  41
GLY A  45
THR A 345
LEU A 121
GLY A 108
 None
None
NAP  A1001 (-3.2A)
None
None
 1.39A 2fn1A-1xkdA:
undetectable		 2fn1A-1xkdA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 ILE A 185
GLY A 133
GLU A 186
LEU A 233
GLY A 156
 None
 1.29A 2fn1A-2ap1A:
undetectable		 2fn1A-2ap1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bde CYTOSOLIC IMP-GMP
SPECIFIC
5'-NUCLEOTIDASE

(Legionella
pneumophila) 		PF05761
(5_nucleotid) 		5 ILE A  20
GLY A 302
THR A  27
LEU A 438
GLY A  21
 None
 1.23A 2fn1A-2bdeA:
undetectable		 2fn1A-2bdeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 326
GLU A 358
GLY A 317
LEU A 359
GLY A 321
 None
 1.40A 2fn1A-2cxeA:
undetectable		 2fn1A-2cxeA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 ILE A 188
GLY A  77
THR A  75
LEU A  63
GLY A 205
 None
PLP  A1209 (-3.4A)
None
None
None
 1.20A 2fn1A-2e7jA:
undetectable		 2fn1A-2e7jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 ILE A 218
GLU A 213
HIS A 229
LEU A 292
GLY A 217
 None
 1.02A 2fn1A-2eh6A:
undetectable		 2fn1A-2eh6A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		5 ILE A  15
GLY B 287
THR B 243
HIS A   9
GLY A  13
 None
 1.16A 2fn1A-2gezA:
undetectable		 2fn1A-2gezA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 5 GLY A 204
THR A 205
HIS A 248
GLY A 181
LYS A 250
 None
 1.43A 2fn1A-2iouA:
undetectable		 2fn1A-2iouA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxh POLY(U)-BINDING-SPLI
CING FACTOR PUF60

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A 183
GLY A 154
HIS A 152
LEU A 123
GLY A 117
 None
 1.43A 2fn1A-2kxhA:
undetectable		 2fn1A-2kxhA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE
THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin)
PF01507
(PAPS_reduct) 		5 ILE B  72
GLY B  92
GLU A 238
LEU B  79
GLY B  74
 None
 1.38A 2fn1A-2o8vB:
undetectable		 2fn1A-2o8vB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 ILE A 385
GLY A 343
THR A 294
HIS A  77
GLY A 341
 None
 1.16A 2fn1A-2p9bA:
undetectable		 2fn1A-2p9bA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ran ANNEXIN V

(Rattus
norvegicus) 		PF00191
(Annexin) 		5 ILE A 219
GLY A 181
THR A 187
GLU A 182
LEU A 196
 None
CA  A 324 (-4.1A)
CA  A 324 ( 4.8A)
None
None
 1.23A 2fn1A-2ranA:
undetectable		 2fn1A-2ranA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrn PROTEASE I

(Deinococcus
radiodurans) 		PF01965
(DJ-1_PfpI) 		5 GLY A  84
THR A  85
GLU A  21
HIS A 116
GLY A  54
 CSO  A 115 ( 4.2A)
None
None
CSO  A 115 ( 3.9A)
None
 1.09A 2fn1A-2vrnA:
undetectable		 2fn1A-2vrnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 5 ILE A 162
GLY A 159
THR A 157
LEU A 150
GLY A 161
 None
 1.08A 2fn1A-2wteA:
undetectable		 2fn1A-2wteA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 385
GLU A  58
GLY A 416
THR A 446
GLU A 387
 None
 1.37A 2fn1A-2wvgA:
undetectable		 2fn1A-2wvgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE

(Lactobacillus
delbrueckii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 265
GLU A 239
LEU A 287
GLY A 238
GLU A 266
 None
 1.20A 2fn1A-2yq4A:
undetectable		 2fn1A-2yq4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ILE A 466
GLY A 469
LEU A 476
GLY A 465
GLU A 494
 None
 1.14A 2fn1A-2z66A:
undetectable		 2fn1A-2z66A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 ILE A  15
GLY B 276
THR B 230
HIS A   9
GLY A  13
 None
None
ASP  B 501 ( 3.8A)
None
None
 1.18A 2fn1A-2zalA:
undetectable		 2fn1A-2zalA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 GLY A 185
GLU A 189
ARG A 146
GLY A 218
GLU A 209
 None
 1.37A 2fn1A-2zqqA:
undetectable		 2fn1A-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE

(Homo sapiens) 		PF00378
(ECH_1) 		5 ILE A 161
GLY A 185
GLU A 189
GLY A 218
GLU A 209
 None
 1.38A 2fn1A-2zqqA:
undetectable		 2fn1A-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7l GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Escherichia
coli) 		PF01597
(GCV_H) 		5 ILE A 104
GLU A  14
LEU A  16
GLY A  75
GLU A 111
 None
 1.15A 2fn1A-3a7lA:
undetectable		 2fn1A-3a7lA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 240
GLY A 257
THR A 258
HIS A 318
ARG A 387
GLY A 403
GLU A 416
LYS A 420
 None
 0.73A 2fn1A-3bzmA:
42.0		 2fn1A-3bzmA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 240
GLY A 257
THR A 258
HIS A 318
LEU A 386
ARG A 387
GLU A 416
LYS A 420
 None
 0.67A 2fn1A-3bzmA:
42.0		 2fn1A-3bzmA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		5 ILE A  34
GLY A  38
THR A 343
LEU A 116
GLY A 103
 None
 1.40A 2fn1A-3dmsA:
undetectable		 2fn1A-3dmsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		5 ILE A 142
GLY A  27
THR A  28
HIS A  21
LEU A 121
 None
 1.42A 2fn1A-3gfvA:
undetectable		 2fn1A-3gfvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		5 ILE A 150
GLY A  65
GLU A 223
HIS A  66
GLY A 224
 None
 1.33A 2fn1A-3gmiA:
undetectable		 2fn1A-3gmiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		6 GLU A 258
GLY A 275
THR A 276
GLU A 302
HIS A 336
LEU A 404
 None
 0.79A 2fn1A-3gseA:
35.5		 2fn1A-3gseA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		5 ILE A  54
HIS A 140
LEU A 126
GLY A  58
GLU A  57
 None
 1.41A 2fn1A-3h2iA:
undetectable		 2fn1A-3h2iA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		5 GLY A 275
THR A 278
GLU A 262
LEU A 346
GLY A 266
 None
 1.32A 2fn1A-3hmuA:
undetectable		 2fn1A-3hmuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		5 GLU A 309
GLY A 254
THR A 255
GLU A 246
GLY A 247
 None
 1.40A 2fn1A-3humA:
undetectable		 2fn1A-3humA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 ILE A 243
GLY A  94
THR A 236
LEU A 114
GLY A 239
 None
None
None
None
SSA  A 442 (-3.5A)
 1.28A 2fn1A-3hxwA:
undetectable		 2fn1A-3hxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 ILE A  10
GLY A  47
LEU A 245
GLY A  12
GLU A  41
 None
None
None
FAD  A 600 (-3.4A)
FAD  A 600 (-2.7A)
 1.23A 2fn1A-3i6dA:
undetectable		 2fn1A-3i6dA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7j BETA-LACTAMASE
MB2281C

(Mycobacterium
bovis) 		PF00144
(Beta-lactamase) 		5 ILE A 234
THR A 178
HIS A 174
ARG A  48
GLY A 225
 None
 1.32A 2fn1A-3i7jA:
undetectable		 2fn1A-3i7jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		5 ILE A 158
GLU A 197
GLY A 155
THR A 260
GLY A 157
 None
 1.09A 2fn1A-3io0A:
undetectable		 2fn1A-3io0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivp PUTATIVE
TRANSPOSON-RELATED
DNA-BINDING PROTEIN

(Clostridioides
difficile) 		PF01381
(HTH_3) 		5 ILE A  17
GLY A  49
HIS A  51
LEU A  57
GLY A  14
 None
 1.29A 2fn1A-3ivpA:
undetectable		 2fn1A-3ivpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ILE A  30
GLY A 366
THR A 367
HIS A 364
GLY A  33
 None
 1.29A 2fn1A-3lp8A:
undetectable		 2fn1A-3lp8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 GLU A 291
GLY A 391
GLU A 390
LEU A 365
GLY A 325
 None
 1.33A 2fn1A-3lpsA:
undetectable		 2fn1A-3lpsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mez MANNOSE-SPECIFIC
LECTIN 3 CHAIN 1
MANNOSE-SPECIFIC
LECTIN 3 CHAIN 2

(Crocus vernus) 		PF01453
(B_lectin) 		5 ILE A 104
GLY B  89
HIS B  65
LEU B  63
GLY B  86
 None
 1.27A 2fn1A-3mezA:
undetectable		 2fn1A-3mezA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 322
THR A 274
HIS A  63
LEU A 230
GLY A 320
 None
None
ZN  A 425 (-3.2A)
KCX  A 191 ( 4.0A)
None
 1.32A 2fn1A-3mkvA:
undetectable		 2fn1A-3mkvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 ILE A 357
GLY A 319
THR A 271
HIS A  63
GLY A 317
 None
None
None
ZN  A 425 (-3.3A)
None
 1.25A 2fn1A-3n2cA:
undetectable		 2fn1A-3n2cA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		5 ILE A 194
GLY A 333
THR A 309
GLY A 331
GLU A 313
 None
 1.35A 2fn1A-3nx3A:
undetectable		 2fn1A-3nx3A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		7 GLU A 197
GLY A 214
HIS A 276
ARG A 348
GLY A 364
GLU A 377
LYS A 381
 None
SO4  A 404 (-3.8A)
None
None
SO4  A 404 (-3.8A)
SO4  A 404 (-4.1A)
SO4  A 404 (-2.9A)
 0.62A 2fn1A-3os6A:
41.7		 2fn1A-3os6A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 GLY A 143
THR A 144
GLU A 112
LEU A 133
GLU A 227
 None
None
PG4  A 260 (-3.3A)
None
None
 1.32A 2fn1A-3peaA:
undetectable		 2fn1A-3peaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		8 GLU A 201
GLY A 218
THR A 219
GLU A 244
HIS A 279
ARG A 352
GLU A 382
LYS A 386
 BEZ  A 701 ( 4.3A)
BEZ  A 701 (-3.5A)
BEZ  A 701 (-4.0A)
MG  A 700 ( 2.5A)
BEZ  A 701 (-3.8A)
PYR  A 702 ( 3.9A)
MG  A 700 ( 2.5A)
PYR  A 702 ( 3.1A)
 0.31A 2fn1A-3r75A:
43.7		 2fn1A-3r75A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 ILE A   7
GLY A  34
GLU A  32
LEU A  96
GLY A   8
 None
None
FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.2A)
 1.35A 2fn1A-3r9uA:
undetectable		 2fn1A-3r9uA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 ILE A 207
GLU A 252
GLU A 297
LEU A 404
GLY A 421
 VAE  A 451 (-4.2A)
None
MG  A 452 (-3.8A)
VAE  A 451 (-3.8A)
VAE  A 451 ( 4.2A)
 0.81A 2fn1A-3rv6A:
48.6		 2fn1A-3rv6A:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 ILE A 422
GLY A 213
THR A 242
GLU A 520
LEU A 145
 None
 1.18A 2fn1A-3vtrA:
undetectable		 2fn1A-3vtrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 GLY A 345
GLU A 340
LEU A 304
GLY A 219
GLU A 343
 None
 1.38A 2fn1A-3wkyA:
undetectable		 2fn1A-3wkyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ILE A  95
GLY A  42
THR A  43
GLU A  93
GLY A  94
 None
 1.20A 2fn1A-3zyvA:
undetectable		 2fn1A-3zyvA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 ILE A 145
GLY A  91
LEU A 133
GLY A 157
GLU A 159
 None
 1.32A 2fn1A-4cgyA:
undetectable		 2fn1A-4cgyA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 ILE A 413
GLY A 399
THR A 398
LEU A 344
GLY A 414
 None
 0.98A 2fn1A-4dg8A:
undetectable		 2fn1A-4dg8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ess OR187

(synthetic
construct) 		PF01661
(Macro) 		5 THR A  63
HIS A  75
LEU A  38
GLY A  66
GLU A  48
 None
 1.33A 2fn1A-4essA:
undetectable		 2fn1A-4essA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 389
GLU A 271
GLY A 395
GLY A 391
GLU A 393
 GOL  A 603 ( 4.7A)
GOL  A 603 ( 2.8A)
None
None
None
 1.34A 2fn1A-4ha6A:
undetectable		 2fn1A-4ha6A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu1 MAF-LIKE PROTEIN
YCEF

(Escherichia
coli) 		PF02545
(Maf) 		5 ILE A  66
GLY A 105
THR A 104
LEU A 177
GLY A  67
 None
 1.16A 2fn1A-4lu1A:
undetectable		 2fn1A-4lu1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLU A  14
GLY A  17
THR A  20
GLY A  40
GLU A 220
 MLI  A 502 (-4.7A)
MLI  A 502 (-3.2A)
None
MLI  A 502 (-4.8A)
None
 1.18A 2fn1A-4m9dA:
undetectable		 2fn1A-4m9dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ILE A  37
GLY A  48
GLU A  42
HIS A  51
GLY A  38
 None
 1.37A 2fn1A-4nnzA:
undetectable		 2fn1A-4nnzA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		5 GLY A  43
GLU A  40
LEU A 222
ARG A 225
GLY A  50
 None
 1.17A 2fn1A-4petA:
undetectable		 2fn1A-4petA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 304
HIS A 303
LEU A 342
GLY A 339
GLU A 349
 None
 1.39A 2fn1A-4r8eA:
undetectable		 2fn1A-4r8eA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A 211
GLY A 204
HIS A 203
LEU A  20
GLY A 209
 None
 1.40A 2fn1A-4rpfA:
undetectable		 2fn1A-4rpfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 ILE A  32
GLY A  41
HIS A  38
LEU A 217
GLY A  10
 None
FDA  A 403 (-3.2A)
None
None
FDA  A 403 (-3.1A)
 1.42A 2fn1A-4xgkA:
undetectable		 2fn1A-4xgkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE A 475
GLY A 490
THR A 486
GLU A 421
GLY A 438
 None
None
MCN  A 801 (-3.4A)
None
None
 1.41A 2fn1A-4zohA:
undetectable		 2fn1A-4zohA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi) 		PF03702
(AnmK) 		5 ILE A 190
GLU A 362
THR A 116
HIS A 113
GLY A 269
 None
 1.43A 2fn1A-4zxzA:
undetectable		 2fn1A-4zxzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		5 ILE A  66
GLU A 124
GLY A 142
GLY A  67
GLU A 140
 None
 1.25A 2fn1A-5bwiA:
undetectable		 2fn1A-5bwiA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 ILE E 588
GLU E 310
THR E 356
LEU E 210
GLY E 593
 None
 1.37A 2fn1A-5c4gE:
undetectable		 2fn1A-5c4gE:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 ILE A  81
HIS A 108
LEU A  74
ARG A 178
GLY A  80
 None
 1.27A 2fn1A-5cjuA:
undetectable		 2fn1A-5cjuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		5 ILE A 246
GLU A  95
GLY A  73
THR A  74
GLY A 247
 None
 1.19A 2fn1A-5ctmA:
undetectable		 2fn1A-5ctmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 GLU A 307
GLY A 324
THR A 325
HIS A 388
GLY A 475
 0GA  A 604 ( 4.5A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
 0.72A 2fn1A-5cwaA:
38.4		 2fn1A-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 ILE A 321
GLY A 329
LEU A  98
GLY A 322
GLU A 105
 None
 1.31A 2fn1A-5ddsA:
undetectable		 2fn1A-5ddsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 310
GLY A 147
HIS A 209
LEU A 175
GLY A 316
 None
NAP  A 401 ( 4.4A)
None
None
None
 1.32A 2fn1A-5eioA:
undetectable		 2fn1A-5eioA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 ILE H  41
GLU H  73
GLY H 107
THR H 106
GLY H 102
 None
 1.31A 2fn1A-5fg9H:
undetectable		 2fn1A-5fg9H:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		11 ILE A 195
GLU A 240
GLY A 257
THR A 258
GLU A 284
HIS A 321
LEU A 390
ARG A 391
GLY A 407
GLU A 420
LYS A 424
 ACT  A 502 ( 4.8A)
None
ACT  A 503 (-3.2A)
ACT  A 503 (-3.7A)
FE2  A 501 ( 2.7A)
ACT  A 503 ( 4.1A)
ACT  A 502 (-3.5A)
ACT  A 502 (-3.5A)
ACT  A 503 (-3.8A)
FE2  A 501 ( 2.8A)
ACT  A 503 ( 2.3A)
 0.23A 2fn1A-5jy9A:
72.8		 2fn1A-5jy9A:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzd ISOCHORISMATE
SYNTHASE ENTC

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		8 GLU A 197
GLY A 214
GLU A 241
HIS A 276
ARG A 347
GLY A 363
GLU A 376
LYS A 380
 ISC  A 401 (-3.0A)
ISC  A 401 (-3.2A)
MG  A 402 ( 2.4A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.5A)
ISC  A 401 (-3.3A)
MG  A 402 ( 2.6A)
ISC  A 401 (-3.0A)
 0.49A 2fn1A-5jzdA:
40.2		 2fn1A-5jzdA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 388
GLY A 454
LEU A 450
GLY A 402
GLU A 401
 None
 1.27A 2fn1A-5keiA:
undetectable		 2fn1A-5keiA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 5 ILE A 386
GLU A  58
GLY A 417
THR A 447
GLU A 388
 None
 1.35A 2fn1A-5npuA:
undetectable		 2fn1A-5npuA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 ILE A 366
GLU A 415
GLY A 372
GLY A 367
GLU A 368
 None
 1.34A 2fn1A-5ul4A:
undetectable		 2fn1A-5ul4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vq5 ADHESIN

(Escherichia
coli) 		no annotation 5 ILE A  97
GLY A  39
THR A  40
LEU A 186
GLY A  98
 None
 1.30A 2fn1A-5vq5A:
undetectable		 2fn1A-5vq5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xga OSMOLARITY SENSOR
PROTEIN ENVZ

(Escherichia
coli) 		no annotation 5 ILE A  53
GLU A  20
THR A 117
LEU A  17
GLY A  52
 None
ACY  A 203 ( 4.1A)
None
None
None
 1.38A 2fn1A-5xgaA:
undetectable		 2fn1A-5xgaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 5 ILE A  62
GLY A  97
THR A  96
GLY A 317
GLU A 316
 None
 1.26A 2fn1A-6b5fA:
undetectable		 2fn1A-6b5fA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 ILE A  38
GLY A  42
THR A 347
LEU A 120
GLY A 107
 None
None
EE1  A 501 (-3.6A)
None
None
 1.31A 2fn1A-6c0eA:
undetectable		 2fn1A-6c0eA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8v COENZYME PQQ
SYNTHESIS PROTEIN E

(Methylobacterium
extorquens) 		no annotation 5 GLY A 101
THR A  99
LEU A 112
GLY A 104
GLU A  74
 None
 1.32A 2fn1A-6c8vA:
undetectable		 2fn1A-6c8vA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A  36
GLU A  25
GLY A  18
LEU A  51
GLY A  15
 None
None
NAP  A 301 (-3.2A)
None
NAP  A 301 ( 4.7A)
 1.39A 2fn1A-6ci9A:
undetectable		 2fn1A-6ci9A:
10.40