SIMILAR PATTERNS OF AMINO ACIDS FOR 2FL5_H_RBFH201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 GLU K  36
GLU K  72
PHE N 140
VAL J 158
TYR N 159
 None
 1.45A 2fl5D-3rkoK:
undetectable
2fl5H-3rkoK:
undetectable
2fl5L-3rkoK:
undetectable		 2fl5D-3rkoK:
20.45
2fl5H-3rkoK:
20.45
2fl5L-3rkoK:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Conexibacter
woesei) 		PF13407
(Peripla_BP_4) 		5 GLU A 187
ARG A 194
GLU A 191
VAL A 174
TYR A 236
 None
 1.39A 2fl5D-4kq9A:
0.0
2fl5H-4kq9A:
0.0
2fl5L-4kq9A:
0.0		 2fl5D-4kq9A:
21.26
2fl5H-4kq9A:
21.26
2fl5L-4kq9A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		5 GLU A  98
ARG A 157
VAL A 120
TYR A 104
TYR A  64
 None
 1.32A 2fl5D-4zfmA:
0.0
2fl5H-4zfmA:
0.0
2fl5L-4zfmA:
0.0		 2fl5D-4zfmA:
20.34
2fl5H-4zfmA:
20.34
2fl5L-4zfmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 GLU B 640
TYR B 493
GLU B 479
PHE B 477
VAL B 155
 None
 1.43A 2fl5D-5iz5B:
0.0
2fl5H-5iz5B:
0.8
2fl5L-5iz5B:
1.8		 2fl5D-5iz5B:
15.36
2fl5H-5iz5B:
15.36
2fl5L-5iz5B:
14.71