SIMILAR PATTERNS OF AMINO ACIDS FOR 2FL5_F_RBFF204

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		4 TYR A 399
ARG A 372
GLU A 376
PHE A 377
 None
 1.06A 2fl5E-1akcA:
undetectable
2fl5F-1akcA:
undetectable		 2fl5E-1akcA:
19.35
2fl5F-1akcA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 GLU A 123
PHE A 204
VAL A  53
TYR A 312
 None
SHF  A 407 (-4.0A)
None
SHF  A 407 (-4.8A)
 1.12A 2fl5E-1b4eA:
undetectable
2fl5F-1b4eA:
undetectable		 2fl5E-1b4eA:
21.21
2fl5F-1b4eA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ASN A 503
ARG A 480
GLU A 461
VAL A 577
 None
 1.09A 2fl5E-1c7tA:
2.2
2fl5F-1c7tA:
2.2		 2fl5E-1c7tA:
12.94
2fl5F-1c7tA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma) 		4 TYR C 109
ARG C 105
VAL C 116
TYR C 113
 None
 1.02A 2fl5E-1e6vC:
undetectable
2fl5F-1e6vC:
undetectable		 2fl5E-1e6vC:
21.80
2fl5F-1e6vC:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR D 585
TYR D 524
ARG D 545
VAL D 571
 None
 0.95A 2fl5E-1hqrD:
undetectable
2fl5F-1hqrD:
undetectable		 2fl5E-1hqrD:
20.44
2fl5F-1hqrD:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2

(Homo sapiens) 		PF00790
(VHS) 		4 TYR A 152
ARG A 130
GLU A 133
VAL A 113
 None
 1.18A 2fl5E-1mhqA:
undetectable
2fl5F-1mhqA:
undetectable		 2fl5E-1mhqA:
19.91
2fl5F-1mhqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		4 ARG A 110
GLU A 111
PHE A  39
VAL A 120
 None
 1.02A 2fl5E-1px5A:
0.3
2fl5F-1px5A:
0.0		 2fl5E-1px5A:
19.49
2fl5F-1px5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9k TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1

(Mus musculus) 		PF07686
(V-set) 		4 TYR A 111
ARG A  57
PHE A  85
VAL A 129
 None
 0.99A 2fl5E-1u9kA:
10.8
2fl5F-1u9kA:
11.5		 2fl5E-1u9kA:
18.69
2fl5F-1u9kA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukr ENDO-1,4-B-XYLANASE
I

(Aspergillus
niger) 		PF00457
(Glyco_hydro_11) 		4 TYR A 108
ARG A 134
GLU A  84
VAL A 101
 None
 1.10A 2fl5E-1ukrA:
0.9
2fl5F-1ukrA:
1.1		 2fl5E-1ukrA:
24.54
2fl5F-1ukrA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		4 TYR A 439
ASN A 455
GLU A 450
VAL A 557
 None
 1.16A 2fl5E-1w8jA:
undetectable
2fl5F-1w8jA:
0.0		 2fl5E-1w8jA:
14.62
2fl5F-1w8jA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		4 ARG A 168
GLU A 160
VAL A 151
TYR A 148
 None
 1.12A 2fl5E-1xq9A:
undetectable
2fl5F-1xq9A:
undetectable		 2fl5E-1xq9A:
20.15
2fl5F-1xq9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 TYR A 115
ARG A 141
GLU A  91
VAL A 108
 None
 1.13A 2fl5E-1ynaA:
undetectable
2fl5F-1ynaA:
undetectable		 2fl5E-1ynaA:
21.08
2fl5F-1ynaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TYR A 589
TYR A 677
ASN A 673
GLU A 662
 None
 1.13A 2fl5E-1z68A:
undetectable
2fl5F-1z68A:
undetectable		 2fl5E-1z68A:
14.78
2fl5F-1z68A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 TYR A 176
ARG A 204
PHE A 185
VAL A 329
 None
 0.99A 2fl5E-1z8lA:
undetectable
2fl5F-1z8lA:
undetectable		 2fl5E-1z8lA:
14.35
2fl5F-1z8lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbd RABPHILIN-3A

(Rattus
norvegicus) 		PF00071
(Ras) 		4 TYR A 102
GLU A 163
PHE A 161
VAL A 113
 None
 0.80A 2fl5E-1zbdA:
undetectable
2fl5F-1zbdA:
undetectable		 2fl5E-1zbdA:
20.63
2fl5F-1zbdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		4 TYR A 253
GLU A 249
VAL A 101
TYR A  92
 None
 1.08A 2fl5E-1zovA:
undetectable
2fl5F-1zovA:
undetectable		 2fl5E-1zovA:
19.44
2fl5F-1zovA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		4 ARG A  98
GLU A  70
PHE A  55
VAL A 114
 None
 0.92A 2fl5E-1zupA:
undetectable
2fl5F-1zupA:
undetectable		 2fl5E-1zupA:
19.37
2fl5F-1zupA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 TYR A 183
GLU A 190
VAL A 197
TYR A 222
 None
 1.16A 2fl5E-2a5hA:
undetectable
2fl5F-2a5hA:
undetectable		 2fl5E-2a5hA:
18.47
2fl5F-2a5hA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daq WHSC1L1 PROTEIN,
ISOFORM LONG

(Homo sapiens) 		PF00855
(PWWP) 		4 TYR A  59
GLU A  94
PHE A  52
VAL A  17
 None
 1.14A 2fl5E-2daqA:
undetectable
2fl5F-2daqA:
undetectable		 2fl5E-2daqA:
20.10
2fl5F-2daqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 TYR A  51
ARG A 386
GLU A  29
TYR A 382
 None
None
SO4  A 604 ( 4.7A)
SO4  A 604 (-4.8A)
 1.14A 2fl5E-2dwcA:
3.2
2fl5F-2dwcA:
undetectable		 2fl5E-2dwcA:
19.16
2fl5F-2dwcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 TYR A 145
GLU A 137
PHE A 141
VAL A 219
 None
 1.17A 2fl5E-2ehqA:
undetectable
2fl5F-2ehqA:
undetectable		 2fl5E-2ehqA:
15.86
2fl5F-2ehqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2f CYTOLETHAL
DISTENDING TOXIN C

(Aggregatibacter
actinomycetemcomitans) 		PF03498
(CDtoxinA) 		4 ASN C  53
ARG C  39
GLU C  67
TYR C  56
 None
 1.09A 2fl5E-2f2fC:
undetectable
2fl5F-2f2fC:
undetectable		 2fl5E-2f2fC:
20.75
2fl5F-2f2fC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzh RAS-RELATED PROTEIN
RAB-11A

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A  91
GLU A 152
PHE A 150
VAL A 102
 None
 0.81A 2fl5E-2gzhA:
undetectable
2fl5F-2gzhA:
undetectable		 2fl5E-2gzhA:
23.85
2fl5F-2gzhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		4 GLU A 384
PHE A 582
VAL A 251
TYR A 581
 None
 1.17A 2fl5E-2i7nA:
undetectable
2fl5F-2i7nA:
undetectable		 2fl5E-2i7nA:
21.21
2fl5F-2i7nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF04494
(TFIID_NTD2) 		4 TYR A 184
GLU A 215
PHE A 237
VAL A 222
 None
 0.91A 2fl5E-2j49A:
undetectable
2fl5F-2j49A:
undetectable		 2fl5E-2j49A:
19.27
2fl5F-2j49A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 ASN A  41
GLU A  32
VAL A   7
TYR A  44
 None
 1.17A 2fl5E-2jh9A:
undetectable
2fl5F-2jh9A:
undetectable		 2fl5E-2jh9A:
17.54
2fl5F-2jh9A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzb AUTOPHAGY-RELATED
PROTEIN 19

(Saccharomyces
cerevisiae) 		PF12744
(ATG19_autophagy) 		4 TYR A 317
ASN A 279
ARG A 260
PHE A 278
 None
 1.18A 2fl5E-2kzbA:
undetectable
2fl5F-2kzbA:
3.7		 2fl5E-2kzbA:
17.59
2fl5F-2kzbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l90 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Mus musculus) 		PF01625
(PMSR) 		4 TYR A 200
TYR A 160
ARG A 194
VAL A  67
 None
None
MYR  A  21 ( 3.5A)
None
 0.69A 2fl5E-2l90A:
undetectable
2fl5F-2l90A:
undetectable		 2fl5E-2l90A:
22.96
2fl5F-2l90A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		4 TYR A 291
ARG A 290
PHE A 242
VAL A 295
 None
 1.10A 2fl5E-2oewA:
undetectable
2fl5F-2oewA:
undetectable		 2fl5E-2oewA:
20.90
2fl5F-2oewA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 TYR A  33
ASN A  32
ARG A 128
GLU A 125
 None
 1.11A 2fl5E-2po4A:
undetectable
2fl5F-2po4A:
undetectable		 2fl5E-2po4A:
10.49
2fl5F-2po4A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 TYR A  25
GLU A  23
VAL A  38
TYR A  49
 None
 1.18A 2fl5E-2qzpA:
undetectable
2fl5F-2qzpA:
undetectable		 2fl5E-2qzpA:
16.76
2fl5F-2qzpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 ASN A 202
ARG A   2
VAL A 240
TYR A 241
 None
 1.04A 2fl5E-2r3bA:
undetectable
2fl5F-2r3bA:
undetectable		 2fl5E-2r3bA:
20.38
2fl5F-2r3bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		4 TYR A 137
ARG A 163
GLU A 116
VAL A 130
 None
 1.10A 2fl5E-2vg9A:
undetectable
2fl5F-2vg9A:
undetectable		 2fl5E-2vg9A:
19.41
2fl5F-2vg9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 TYR A  57
GLU A  65
PHE A  86
VAL A 132
 None
 1.05A 2fl5E-2wedA:
undetectable
2fl5F-2wedA:
undetectable		 2fl5E-2wedA:
20.92
2fl5F-2wedA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 TYR A  58
ARG A 120
VAL A   6
TYR A   4
 None
 0.98A 2fl5E-2wteA:
undetectable
2fl5F-2wteA:
undetectable		 2fl5E-2wteA:
21.25
2fl5F-2wteA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 TYR A  58
GLU A  21
VAL A   6
TYR A   4
 None
 1.13A 2fl5E-2wteA:
undetectable
2fl5F-2wteA:
undetectable		 2fl5E-2wteA:
21.25
2fl5F-2wteA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xq1 PEROXISOMAL CATALASE

(Ogataea angusta) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 TYR A 478
ARG A 146
GLU A 181
TYR A 436
 None
 1.08A 2fl5E-2xq1A:
undetectable
2fl5F-2xq1A:
undetectable		 2fl5E-2xq1A:
18.66
2fl5F-2xq1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq2 BVDV1 E2

(Pestivirus A) 		PF16329
(Pestivirus_E2) 		4 TYR A 221
TYR A 234
ARG A 227
GLU A 203
 None
 1.11A 2fl5E-2yq2A:
4.5
2fl5F-2yq2A:
3.9		 2fl5E-2yq2A:
21.38
2fl5F-2yq2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		4 TYR A  51
ASN A  46
GLU A  44
VAL A  96
 None
 0.86A 2fl5E-3fotA:
undetectable
2fl5F-3fotA:
undetectable		 2fl5E-3fotA:
18.18
2fl5F-3fotA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 TYR A 183
ARG A 248
PHE A 270
VAL A 285
 None
 0.89A 2fl5E-3gcwA:
undetectable
2fl5F-3gcwA:
undetectable		 2fl5E-3gcwA:
17.96
2fl5F-3gcwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A  63
ASN A  75
ARG A  88
TYR A  74
 None
 1.08A 2fl5E-3gdnA:
undetectable
2fl5F-3gdnA:
undetectable		 2fl5E-3gdnA:
18.27
2fl5F-3gdnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 GLU A 207
PHE A 197
VAL A 230
TYR A 215
 None
 1.06A 2fl5E-3hc1A:
undetectable
2fl5F-3hc1A:
undetectable		 2fl5E-3hc1A:
21.04
2fl5F-3hc1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 TYR A 236
ASN A 258
ARG A 259
VAL A 256
 None
None
PO4  A 402 (-2.5A)
None
 1.15A 2fl5E-3hfqA:
undetectable
2fl5F-3hfqA:
undetectable		 2fl5E-3hfqA:
21.57
2fl5F-3hfqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		4 TYR A 213
ARG A  80
GLU A 292
TYR A  82
 None
GOL  A 397 (-4.4A)
GOL  A 397 (-3.6A)
None
 1.07A 2fl5E-3jtxA:
undetectable
2fl5F-3jtxA:
undetectable		 2fl5E-3jtxA:
20.20
2fl5F-3jtxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens) 		PF00168
(C2) 		4 TYR A1565
ARG A1622
PHE A1609
VAL A1654
 None
 1.07A 2fl5E-3jzyA:
2.2
2fl5F-3jzyA:
undetectable		 2fl5E-3jzyA:
15.05
2fl5F-3jzyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		4 GLU A 196
PHE A 199
VAL A 164
TYR A 130
 None
 1.00A 2fl5E-3kaoA:
undetectable
2fl5F-3kaoA:
undetectable		 2fl5E-3kaoA:
19.51
2fl5F-3kaoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		4 ASN A 153
ARG A  48
GLU A 157
PHE A  90
 None
 0.94A 2fl5E-3khnA:
undetectable
2fl5F-3khnA:
undetectable		 2fl5E-3khnA:
20.92
2fl5F-3khnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klq PUTATIVE PILUS
ANCHORING PROTEIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		4 TYR A  90
TYR A  61
VAL A  86
TYR A  87
 None
 1.03A 2fl5E-3klqA:
2.5
2fl5F-3klqA:
3.5		 2fl5E-3klqA:
22.01
2fl5F-3klqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 4 TYR A 220
GLU A 196
PHE A 190
VAL A 211
 None
 1.15A 2fl5E-3kptA:
2.6
2fl5F-3kptA:
2.8		 2fl5E-3kptA:
20.73
2fl5F-3kptA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 TYR A 557
ASN A 600
ARG A 604
GLU A 535
 None
 0.96A 2fl5E-3kt4A:
undetectable
2fl5F-3kt4A:
undetectable		 2fl5E-3kt4A:
16.11
2fl5F-3kt4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		4 TYR A 214
ASN A 167
GLU A 165
TYR A 169
 None
 1.09A 2fl5E-3loyA:
undetectable
2fl5F-3loyA:
undetectable		 2fl5E-3loyA:
14.86
2fl5F-3loyA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		4 TYR B 366
GLU B  82
PHE B 224
VAL B 307
 None
 1.09A 2fl5E-3o0rB:
undetectable
2fl5F-3o0rB:
undetectable		 2fl5E-3o0rB:
18.10
2fl5F-3o0rB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 TYR A 246
TYR A 270
PHE A 250
VAL A 206
 None
 1.18A 2fl5E-3oeeA:
undetectable
2fl5F-3oeeA:
undetectable		 2fl5E-3oeeA:
19.41
2fl5F-3oeeA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqh PUTATIVE
UNCHARACTERIZED
PROTEIN YVMC

(Bacillus
licheniformis) 		PF16715
(CDPS) 		4 TYR A 229
GLU A 184
PHE A 188
VAL A 221
 None
 1.09A 2fl5E-3oqhA:
undetectable
2fl5F-3oqhA:
undetectable		 2fl5E-3oqhA:
22.94
2fl5F-3oqhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 TYR A  31
GLU A 189
PHE A  99
TYR A  71
 None
None
None
PO4  A 335 (-3.8A)
 1.04A 2fl5E-3pnzA:
undetectable
2fl5F-3pnzA:
undetectable		 2fl5E-3pnzA:
20.29
2fl5F-3pnzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A  63
ASN A  75
ARG A  88
TYR A  74
 None
 1.03A 2fl5E-3redA:
undetectable
2fl5F-3redA:
undetectable		 2fl5E-3redA:
18.91
2fl5F-3redA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 TYR N 159
GLU K  72
PHE N 140
VAL J 158
 None
 1.01A 2fl5E-3rkoN:
undetectable
2fl5F-3rkoN:
undetectable		 2fl5E-3rkoN:
19.34
2fl5F-3rkoN:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhl DEDICATOR OF
CYTOKINESIS PROTEIN
8

(Mus musculus) 		PF06920
(DHR-2) 		4 TYR A1872
ASN A1917
ARG A1893
PHE A1941
 None
 1.14A 2fl5E-3vhlA:
undetectable
2fl5F-3vhlA:
undetectable		 2fl5E-3vhlA:
19.24
2fl5F-3vhlA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 TYR A 456
TYR A 435
GLU A 416
VAL A 400
 None
 1.03A 2fl5E-3vr1A:
undetectable
2fl5F-3vr1A:
undetectable		 2fl5E-3vr1A:
17.43
2fl5F-3vr1A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ARG A 829
GLU A 609
VAL A 769
TYR A 768
 None
 1.14A 2fl5E-3zyvA:
undetectable
2fl5F-3zyvA:
undetectable		 2fl5E-3zyvA:
9.56
2fl5F-3zyvA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		4 TYR B  58
TYR B 350
ARG B  36
VAL B 341
 None
 1.01A 2fl5E-4a11B:
undetectable
2fl5F-4a11B:
undetectable		 2fl5E-4a11B:
20.50
2fl5F-4a11B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 4 ASN A  63
ARG A  59
GLU A 234
PHE A  64
 None
 0.79A 2fl5E-4ateA:
undetectable
2fl5F-4ateA:
undetectable		 2fl5E-4ateA:
18.01
2fl5F-4ateA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 TYR A 314
ARG A 285
PHE A 292
VAL A 350
 None
 1.16A 2fl5E-4ayrA:
undetectable
2fl5F-4ayrA:
undetectable		 2fl5E-4ayrA:
18.75
2fl5F-4ayrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 TYR A 152
ARG A 336
GLU A 341
VAL A 148
 None
 1.06A 2fl5E-4bgbA:
undetectable
2fl5F-4bgbA:
undetectable		 2fl5E-4bgbA:
20.62
2fl5F-4bgbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR A 241
PHE A 246
VAL A 551
TYR A 550
 None
 1.17A 2fl5E-4cgyA:
undetectable
2fl5F-4cgyA:
undetectable		 2fl5E-4cgyA:
15.17
2fl5F-4cgyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0m RAS-RELATED PROTEIN
RAB-11A

(Homo sapiens) 		PF00071
(Ras) 		4 TYR B  91
GLU B 152
PHE B 150
TYR B  99
 None
 1.12A 2fl5E-4d0mB:
undetectable
2fl5F-4d0mB:
undetectable		 2fl5E-4d0mB:
23.60
2fl5F-4d0mB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0m RAS-RELATED PROTEIN
RAB-11A

(Homo sapiens) 		PF00071
(Ras) 		4 TYR B  91
GLU B 152
PHE B 150
VAL B 102
 None
 0.70A 2fl5E-4d0mB:
undetectable
2fl5F-4d0mB:
undetectable		 2fl5E-4d0mB:
23.60
2fl5F-4d0mB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 TYR A 417
ASN A 346
GLU A 458
PHE A 343
 None
 1.13A 2fl5E-4eo4A:
undetectable
2fl5F-4eo4A:
undetectable		 2fl5E-4eo4A:
18.61
2fl5F-4eo4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		4 TYR A 162
ARG A   4
GLU A 160
VAL A 198
 None
 1.16A 2fl5E-4eogA:
undetectable
2fl5F-4eogA:
undetectable		 2fl5E-4eogA:
16.28
2fl5F-4eogA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 TYR A 384
ARG A 394
GLU A 391
VAL A 630
 None
 1.16A 2fl5E-4hwtA:
undetectable
2fl5F-4hwtA:
undetectable		 2fl5E-4hwtA:
18.97
2fl5F-4hwtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		4 ASN A 153
ARG A 210
GLU A 148
VAL A 217
 None
 1.12A 2fl5E-4lh7A:
undetectable
2fl5F-4lh7A:
undetectable		 2fl5E-4lh7A:
23.82
2fl5F-4lh7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 TYR A 279
TYR A 139
GLU A 354
TYR A 173
 None
UNL  A 601 ( 4.7A)
UNL  A 601 (-2.8A)
UNL  A 601 ( 4.2A)
 1.14A 2fl5E-4n0rA:
3.9
2fl5F-4n0rA:
3.0		 2fl5E-4n0rA:
16.02
2fl5F-4n0rA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 TYR B 183
ARG B 248
PHE B 270
VAL B 285
 None
 0.94A 2fl5E-4ov6B:
undetectable
2fl5F-4ov6B:
undetectable		 2fl5E-4ov6B:
24.61
2fl5F-4ov6B:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc6 BIFUNCTIONAL AAC/APH

(Staphylococcus
warneri) 		PF13523
(Acetyltransf_8) 		4 TYR A  96
GLU A  57
PHE A  59
VAL A 133
 None
 0.89A 2fl5E-4qc6A:
undetectable
2fl5F-4qc6A:
undetectable		 2fl5E-4qc6A:
20.44
2fl5F-4qc6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		4 TYR A  86
GLU A  60
VAL A 112
TYR A  89
 None
None
NDP  A 401 ( 4.7A)
None
 1.11A 2fl5E-4rgqA:
undetectable
2fl5F-4rgqA:
undetectable		 2fl5E-4rgqA:
18.31
2fl5F-4rgqA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 NUCLEAR PROTEIN
LOCALIZATION PROTEIN
4 HOMOLOG

(Drosophila
melanogaster) 		PF11543
(UN_NPL4) 		4 TYR B  31
GLU B  54
PHE B  46
VAL B  34
 None
 0.98A 2fl5E-4rv0B:
undetectable
2fl5F-4rv0B:
undetectable		 2fl5E-4rv0B:
16.19
2fl5F-4rv0B:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE

(Picrophilus
torridus) 		PF00701
(DHDPS) 		4 TYR A 263
ASN A 247
GLU A 251
TYR A 268
 None
 1.01A 2fl5E-4uxdA:
undetectable
2fl5F-4uxdA:
undetectable		 2fl5E-4uxdA:
21.53
2fl5F-4uxdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 TYR A 229
ARG A 174
GLU A 177
VAL A 153
 None
 1.05A 2fl5E-4w87A:
undetectable
2fl5F-4w87A:
undetectable		 2fl5E-4w87A:
18.44
2fl5F-4w87A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnv P2Y PURINOCEPTOR 1,
RUBREDOXIN, P2Y
PURINOCEPTOR 1

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		4 TYR A 100
TYR A 136
PHE A 131
VAL A 179
 None
 0.98A 2fl5E-4xnvA:
undetectable
2fl5F-4xnvA:
undetectable		 2fl5E-4xnvA:
18.29
2fl5F-4xnvA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		4 TYR A 334
ASN A 325
ARG A 327
GLU A 328
 None
 1.10A 2fl5E-4zxoA:
undetectable
2fl5F-4zxoA:
undetectable		 2fl5E-4zxoA:
19.32
2fl5F-4zxoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 TYR C 108
ARG C 104
VAL C 115
TYR C 112
 None
 1.09A 2fl5E-5a8rC:
undetectable
2fl5F-5a8rC:
undetectable		 2fl5E-5a8rC:
19.70
2fl5F-5a8rC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		4 TYR A 367
ARG A 302
GLU A 294
PHE A 304
 None
PB  A 500 ( 4.7A)
None
None
 1.17A 2fl5E-5b6tA:
undetectable
2fl5F-5b6tA:
undetectable		 2fl5E-5b6tA:
21.05
2fl5F-5b6tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A  63
ASN A  75
ARG A  88
TYR A  74
 None
 1.01A 2fl5E-5eb5A:
undetectable
2fl5F-5eb5A:
undetectable		 2fl5E-5eb5A:
20.58
2fl5F-5eb5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 TYR A 170
ARG B  29
GLU B  50
VAL A  11
 None
 1.16A 2fl5E-5exeA:
undetectable
2fl5F-5exeA:
undetectable		 2fl5E-5exeA:
20.98
2fl5F-5exeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5p PROTEIN SHROOM2

(Homo sapiens) 		PF08687
(ASD2) 		4 TYR A1575
GLU A1556
PHE A1491
VAL A1472
 None
 1.14A 2fl5E-5f5pA:
undetectable
2fl5F-5f5pA:
undetectable		 2fl5E-5f5pA:
23.11
2fl5F-5f5pA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		4 TYR A 181
TYR A 124
ARG A 134
VAL A 115
 None
 0.63A 2fl5E-5i3sA:
undetectable
2fl5F-5i3sA:
undetectable		 2fl5E-5i3sA:
19.15
2fl5F-5i3sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		4 ASN A 203
GLU A 161
VAL A 134
TYR A 176
 None
TRH  A 500 (-2.8A)
None
None
 1.17A 2fl5E-5ifyA:
undetectable
2fl5F-5ifyA:
undetectable		 2fl5E-5ifyA:
22.01
2fl5F-5ifyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 TYR A  85
GLU A  44
VAL A  50
TYR A  70
 None
 1.02A 2fl5E-5jd4A:
undetectable
2fl5F-5jd4A:
undetectable		 2fl5E-5jd4A:
21.39
2fl5F-5jd4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrm ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00457
(Glyco_hydro_11) 		4 TYR A 114
ARG A 140
GLU A  90
VAL A 107
 None
None
None
SO4  A 203 (-4.1A)
 1.16A 2fl5E-5jrmA:
undetectable
2fl5F-5jrmA:
undetectable		 2fl5E-5jrmA:
21.72
2fl5F-5jrmA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A  12
PHE A 569
VAL A 793
TYR A 623
 None
 1.07A 2fl5E-5k6oA:
4.5
2fl5F-5k6oA:
3.2		 2fl5E-5k6oA:
12.71
2fl5F-5k6oA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN

(Candida
albicans) 		PF00071
(Ras) 		4 TYR A  95
GLU A 156
PHE A 154
VAL A 106
 None
 0.78A 2fl5E-5ub8A:
undetectable
2fl5F-5ub8A:
undetectable		 2fl5E-5ub8A:
24.58
2fl5F-5ub8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5z 3C10 FAB LIGHT CHAIN

(Rattus
norvegicus) 		no annotation 4 TYR L 172
GLU L 104
PHE L  10
VAL L 162
 None
 1.17A 2fl5E-5w5zL:
16.4
2fl5F-5w5zL:
12.3		 2fl5E-5w5zL:
18.88
2fl5F-5w5zL:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 TYR A 279
TYR A 311
ARG A 315
VAL A 308
 None
U  B   8 ( 4.1A)
U  B   8 ( 4.4A)
None
 0.99A 2fl5E-5weaA:
undetectable
2fl5F-5weaA:
undetectable		 2fl5E-5weaA:
16.91
2fl5F-5weaA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 TYR A 809
ARG A1074
VAL A 804
TYR A 932
 None
 1.12A 2fl5E-5x59A:
undetectable
2fl5F-5x59A:
undetectable		 2fl5E-5x59A:
11.01
2fl5F-5x59A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 ASN A 172
ARG A 273
GLU A 420
VAL A 156
 None
 0.90A 2fl5E-5xqoA:
undetectable
2fl5F-5xqoA:
0.9		 2fl5E-5xqoA:
20.35
2fl5F-5xqoA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A

(Danio rerio;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A 259
GLU A 199
VAL A 280
TYR A 284
 None
 1.15A 2fl5E-5xszA:
undetectable
2fl5F-5xszA:
undetectable		 2fl5E-5xszA:
17.26
2fl5F-5xszA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 TYR A  70
ARG A  98
GLU A 136
VAL A  50
 None
 1.00A 2fl5E-6conA:
undetectable
2fl5F-6conA:
undetectable		 2fl5E-6conA:
16.50
2fl5F-6conA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 4 TYR A 321
ASN A 279
ARG A 281
VAL A 309
 None
 1.01A 2fl5E-6czmA:
undetectable
2fl5F-6czmA:
undetectable		 2fl5E-6czmA:
undetectable
2fl5F-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 TYR A1013
ASN A1011
VAL A 806
TYR A 804
 None
 1.15A 2fl5E-6d4jA:
undetectable
2fl5F-6d4jA:
undetectable		 2fl5E-6d4jA:
20.42
2fl5F-6d4jA:
18.03