SIMILAR PATTERNS OF AMINO ACIDS FOR 2FK8_A_SAMA302_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvw | PROTEIN(CELLOBIOHYDROLASEII) (Humicolainsolens) |
PF01341(Glyco_hydro_6) | 3 | SER A 107THR A 151GLN A 136 | None | 0.81A | 2fk8A-1bvwA:undetectable | 2fk8A-1bvwA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jgc | BACTERIOFERRITIN (Rhodobactercapsulatus) |
PF00210(Ferritin) | 3 | SER A 48THR A 86GLN A 32 | None | 0.76A | 2fk8A-1jgcA:undetectable | 2fk8A-1jgcA:19.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 3 | SER A 34THR A 94GLN A 99 | SAH A1900 ( 3.6A)SAH A1900 (-4.0A)SAH A1900 (-2.9A) | 0.22A | 2fk8A-1kphA:40.6 | 2fk8A-1kphA:54.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kpi | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 3 | SER A 42THR A 102GLN A 107 | SAH A 900 ( 2.8A)SAH A 900 (-4.0A)SAH A 900 (-2.9A) | 0.32A | 2fk8A-1kpiA:36.9 | 2fk8A-1kpiA:47.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 3 | SER A 34THR A 94GLN A 99 | SAH A 900 ( 2.7A)SAH A 900 (-4.4A)SAH A 900 (-3.1A) | 0.16A | 2fk8A-1l1eA:39.9 | 2fk8A-1l1eA:51.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN ALPHASUBUNITFIBRINOGEN BETACHAIN (Gallus gallus;Gallus gallus) |
PF08702(Fib_alpha)PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 3 | SER B 179THR A 187GLN A 183 | None | 0.80A | 2fk8A-1m1jB:undetectable | 2fk8A-1m1jB:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqu | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Haemophilusinfluenzae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | SER A 15THR A 37GLN A 74 | NoneNAP A1372 (-2.9A)NAP A1372 (-3.0A) | 0.74A | 2fk8A-1pquA:undetectable | 2fk8A-1pquA:20.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tpy | METHOXY MYCOLIC ACIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 3 | SER A 34THR A 94GLN A 99 | SAH A1900 ( 2.7A)SAH A1900 (-4.1A)SAH A1900 (-3.0A) | 0.17A | 2fk8A-1tpyA:39.7 | 2fk8A-1tpyA:51.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1trl | THERMOLYSIN FRAGMENT255 - 316 (Bacillusthermoproteolyticus) |
PF02868(Peptidase_M4_C) | 3 | SER A 291THR A 276GLN A 283 | None | 0.78A | 2fk8A-1trlA:undetectable | 2fk8A-1trlA:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b67 | COG0778:NITROREDUCTASE (Streptococcuspneumoniae) |
PF00881(Nitroreductase) | 3 | SER A 150THR A 28GLN A 146 | None | 0.81A | 2fk8A-2b67A:undetectable | 2fk8A-2b67A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdw | HYPOTHETICAL PROTEINK11E8.1D (Caenorhabditiselegans) |
PF00069(Pkinase) | 3 | SER A 10THR A 46GLN A 80 | None | 0.82A | 2fk8A-2bdwA:undetectable | 2fk8A-2bdwA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bg9 | ACETYLCHOLINERECEPTOR PROTEIN,ALPHA CHAINACETYLCHOLINERECEPTOR PROTEIN,GAMMA CHAIN (Torpedomarmorata;Torpedomarmorata) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb)PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 3 | SER A 302THR A 244GLN E 249 | None | 0.82A | 2fk8A-2bg9A:undetectable | 2fk8A-2bg9A:22.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fk7 | METHOXY MYCOLIC ACIDSYNTHASE 4 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 3 | SER A 43THR A 103GLN A 108 | None | 0.19A | 2fk8A-2fk7A:44.8 | 2fk8A-2fk7A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gz3 | ASPARTATEBETA-SEMIALDEHYDEDEHYDROGENASE (Streptococcuspneumoniae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | SER A 250THR A 302GLN A 132 | None | 0.81A | 2fk8A-2gz3A:undetectable | 2fk8A-2gz3A:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i44 | SERINE-THREONINEPHOSPHATASE 2C (Toxoplasmagondii) |
PF00481(PP2C) | 3 | SER A 145THR A 35GLN A 43 | None | 0.66A | 2fk8A-2i44A:undetectable | 2fk8A-2i44A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph5 | HOMOSPERMIDINESYNTHASE (Legionellapneumophila) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 3 | SER A 227THR A 51GLN A 26 | NAD A 501 ( 4.5A)NoneNone | 0.65A | 2fk8A-2ph5A:undetectable | 2fk8A-2ph5A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pke | HALOACIDDELAHOGENASE-LIKEFAMILY HYDROLASE (Xanthomonascampestris) |
PF13419(HAD_2) | 3 | SER A 147THR A 133GLN A 140 | NoneNone CL A 301 (-4.1A) | 0.83A | 2fk8A-2pkeA:undetectable | 2fk8A-2pkeA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2put | ISOMERASE DOMAIN OFGLUTAMINE-FRUCTOSE-6-PHOSPHATETRANSAMINASE(ISOMERIZING) (Candidaalbicans) |
PF01380(SIS) | 3 | SER A 688THR A 508GLN A 361 | None | 0.80A | 2fk8A-2putA:undetectable | 2fk8A-2putA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyx | TRYPTOPHANHALOGENASE (Shewanellafrigidimarina) |
PF04820(Trp_halogenase) | 3 | SER A 155THR A 147GLN A 89 | None | 0.67A | 2fk8A-2pyxA:2.8 | 2fk8A-2pyxA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5k | MAJOR CAPSID PROTEINL1 (Alphapapillomavirus10) |
PF00500(Late_protein_L1) | 3 | SER A 468THR A 30GLN A 373 | None | 0.78A | 2fk8A-2r5kA:undetectable | 2fk8A-2r5kA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vc6 | DIHYDRODIPICOLINATESYNTHASE (Sinorhizobiummeliloti) |
PF00701(DHDPS) | 3 | SER A 138THR A 146GLN A 111 | None | 0.78A | 2fk8A-2vc6A:undetectable | 2fk8A-2vc6A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdu | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE-ASSOCIATED WD REPEATPROTEIN TRM82 (Saccharomycescerevisiae) |
no annotation | 3 | SER B 316THR B 12GLN B 368 | None | 0.83A | 2fk8A-2vduB:undetectable | 2fk8A-2vduB:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsx | L-CARNITINE/GAMMA-BUTYROBETAINEANTIPORTER (Escherichiacoli) |
PF02028(BCCT) | 3 | SER A 173THR A 429GLN A 330 | None | 0.85A | 2fk8A-2wsxA:undetectable | 2fk8A-2wsxA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yyl | 4-HYDROXYPHENYLACETATE-3-HYDROXYLASE (Thermusthermophilus) |
PF03241(HpaB)PF11794(HpaB_N) | 3 | SER A 101THR A 59GLN A 49 | None | 0.86A | 2fk8A-2yylA:undetectable | 2fk8A-2yylA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2m | PENICILLIN-BINDINGPROTEIN 2XPENICILLIN-BINDINGPROTEIN 2X (Streptococcuspneumoniae;Streptococcuspneumoniae) |
PF03717(PBP_dimer)PF00905(Transpeptidase) | 3 | SER A 196THR B 588GLN B 458 | None | 0.58A | 2fk8A-2z2mA:undetectable | 2fk8A-2z2mA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkt | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Pyrococcushorikoshii) |
PF01676(Metalloenzyme)PF10143(PhosphMutase) | 3 | SER A 357THR A 344GLN A 49 | None | 0.70A | 2fk8A-2zktA:undetectable | 2fk8A-2zktA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zqp | PREPROTEINTRANSLOCASE SECYSUBUNIT (Thermusthermophilus) |
PF00344(SecY) | 3 | SER Y 63THR Y 36GLN Y 161 | None | 0.65A | 2fk8A-2zqpY:undetectable | 2fk8A-2zqpY:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2q | 6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE (Arthrobactersp. KI72) |
PF01425(Amidase) | 3 | SER A 416THR A 343GLN A 126 | None | 0.67A | 2fk8A-3a2qA:undetectable | 2fk8A-3a2qA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpr | DIHYDRODIPICOLINATESYNTHETASE (Corynebacteriumglutamicum) |
PF00701(DHDPS) | 3 | SER A 154THR A 162GLN A 127 | None | 0.78A | 2fk8A-3cprA:undetectable | 2fk8A-3cprA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddh | PUTATIVE HALOACIDDEHALOGENASE-LIKEFAMILY HYDROLASE (Bacteroidesthetaiotaomicron) |
PF13419(HAD_2) | 3 | SER A 140THR A 126GLN A 133 | None CL A 233 ( 4.9A)None | 0.81A | 2fk8A-3ddhA:undetectable | 2fk8A-3ddhA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 3 | SER A 207THR A 849GLN A 660 | None | 0.78A | 2fk8A-3egwA:2.8 | 2fk8A-3egwA:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fy6 | INTEGRON CASSETTEPROTEIN (Vibrio cholerae) |
no annotation | 3 | SER A 50THR A 69GLN A 55 | None | 0.74A | 2fk8A-3fy6A:undetectable | 2fk8A-3fy6A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvy | BACTERIOFERRITIN (Rhodobactersphaeroides) |
PF00210(Ferritin) | 3 | SER A 48THR A 86GLN A 32 | None | 0.85A | 2fk8A-3gvyA:undetectable | 2fk8A-3gvyA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h14 | AMINOTRANSFERASE,CLASSES I AND II (Ruegeriapomeroyi) |
PF00155(Aminotran_1_2) | 3 | SER A 199THR A 176GLN A 151 | NoneNoneGOL A 502 (-3.2A) | 0.77A | 2fk8A-3h14A:3.8 | 2fk8A-3h14A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hij | DIHYDRODIPICOLINATESYNTHASE (Bacillusanthracis) |
PF00701(DHDPS) | 3 | SER A 141THR A 149GLN A 114 | None | 0.78A | 2fk8A-3hijA:undetectable | 2fk8A-3hijA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hrr | AFLATOXINBIOSYNTHESISPOLYKETIDE SYNTHASE (Aspergillusparasiticus) |
PF14765(PS-DH) | 3 | SER A1356THR A1309GLN A1364 | None | 0.85A | 2fk8A-3hrrA:undetectable | 2fk8A-3hrrA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6d | PROTOPORPHYRINOGENOXIDASE (Bacillussubtilis) |
PF01593(Amino_oxidase) | 3 | SER A 188THR A 441GLN A 456 | None | 0.83A | 2fk8A-3i6dA:2.1 | 2fk8A-3i6dA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ian | CHITINASE (Lactococcuslactis) |
PF00704(Glyco_hydro_18) | 3 | SER A 239THR A 266GLN A 262 | None | 0.76A | 2fk8A-3ianA:undetectable | 2fk8A-3ianA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igx | TRANSALDOLASE (Francisellatularensis) |
PF00923(TAL_FSA) | 3 | SER A 249THR A 186GLN A 236 | None | 0.86A | 2fk8A-3igxA:undetectable | 2fk8A-3igxA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 3 | SER A 126THR A 190GLN A 403 | None | 0.60A | 2fk8A-3n58A:2.9 | 2fk8A-3n58A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 3 | SER A 495THR A 244GLN A 242 | None | 0.83A | 2fk8A-3nlcA:2.2 | 2fk8A-3nlcA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntt | CAPSID PROTEIN (Adeno-associateddependoparvovirusB) |
PF00740(Parvo_coat) | 3 | SER A 501THR A 472GLN A 507 | None | 0.83A | 2fk8A-3nttA:undetectable | 2fk8A-3nttA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3om5 | LEVANSUCRASE (Bacillusmegaterium) |
PF02435(Glyco_hydro_68) | 3 | SER A 144THR A 480GLN A 113 | None | 0.58A | 2fk8A-3om5A:undetectable | 2fk8A-3om5A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzr | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Vibrio cholerae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | SER A 14THR A 36GLN A 72 | NoneNAP A 372 (-3.1A)NAP A 372 (-3.6A) | 0.74A | 2fk8A-3pzrA:undetectable | 2fk8A-3pzrA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpf | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
PF06824(Glyco_hydro_125) | 3 | SER A 104THR A 40GLN A 67 | None | 0.67A | 2fk8A-3qpfA:undetectable | 2fk8A-3qpfA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6p | CAPSID PROTEIN (Helicoverpaarmigera stuntvirus) |
PF03566(Peptidase_A21) | 3 | SER A 476THR A 497GLN A 277 | None | 0.79A | 2fk8A-3s6pA:undetectable | 2fk8A-3s6pA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3si9 | DIHYDRODIPICOLINATESYNTHASE (Bartonellahenselae) |
PF00701(DHDPS) | 3 | SER A 143THR A 151GLN A 116 | NoneEDO A 803 ( 4.0A)None | 0.78A | 2fk8A-3si9A:undetectable | 2fk8A-3si9A:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tbf | GLUCOSAMINE--FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE[ISOMERIZING] (Francisellatularensis) |
PF01380(SIS) | 3 | SER A 588THR A 408GLN A 261 | None | 0.79A | 2fk8A-3tbfA:2.1 | 2fk8A-3tbfA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut3 | PLASMINOGENACTIVATOR INHIBITOR1 (Homo sapiens) |
PF00079(Serpin) | 3 | SER A 182THR A 177GLN A 204 | None | 0.85A | 2fk8A-3ut3A:undetectable | 2fk8A-3ut3A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw3 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiathailandensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | SER A 14THR A 36GLN A 72 | None | 0.81A | 2fk8A-3uw3A:undetectable | 2fk8A-3uw3A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr5 | V-TYPE SODIUM ATPASECATALYTIC SUBUNIT A (Enterococcushirae) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 3 | SER A 249THR A 218GLN A 518 | None | 0.70A | 2fk8A-3vr5A:3.3 | 2fk8A-3vr5A:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsc | PROTEIN CYSO (Aeropyrumpernix) |
PF00291(PALP) | 3 | SER A 123THR A 262GLN A 224 | NonePLP A 401 ( 2.7A)SEP A 402 (-3.3A) | 0.83A | 2fk8A-3vscA:3.4 | 2fk8A-3vscA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w2x | EXODEOXYRIBONUCLEASE (Methanothermobacterthermautotrophicus) |
PF03372(Exo_endo_phos) | 3 | SER A 8THR A 61GLN A 98 | None | 0.65A | 2fk8A-3w2xA:undetectable | 2fk8A-3w2xA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmy | EXTRACELLULAREXO-ALPHA-L-ARABINOFURANOSIDASE (Streptomycescoelicolor) |
PF03664(Glyco_hydro_62) | 3 | SER A 217THR A 311GLN A 364 | TRS A 503 ( 4.5A)None CA A 501 (-2.9A) | 0.82A | 2fk8A-3wmyA:undetectable | 2fk8A-3wmyA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnp | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Bacilluscirculans) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 3 | SER A 152THR A 588GLN A 516 | None | 0.82A | 2fk8A-3wnpA:undetectable | 2fk8A-3wnpA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zok | 3-DEHYDROQUINATESYNTHASE (Actinidiachinensis) |
PF01761(DHQ_synthase) | 3 | SER A 194THR A 183GLN A 148 | NoneNAD A1381 (-4.9A)None | 0.83A | 2fk8A-3zokA:undetectable | 2fk8A-3zokA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 3 | SER A1337THR A 682GLN A 497 | None | 0.84A | 2fk8A-4bedA:undetectable | 2fk8A-4bedA:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4drs | PYRUVATE KINASE (Cryptosporidiumparvum) |
PF00224(PK)PF02887(PK_C) | 3 | SER A 71THR A 449GLN A 43 | None | 0.85A | 2fk8A-4drsA:2.6 | 2fk8A-4drsA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6x | GLYOXALASE/BLEOMYCINRESISTANCEPROTEIN/DIOXYGENASE (Catenulisporaacidiphila) |
PF00903(Glyoxalase) | 3 | SER A 79THR A 104GLN A 101 | None | 0.80A | 2fk8A-4g6xA:undetectable | 2fk8A-4g6xA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gdj | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 3 | SER A 179THR A 279GLN A 350 | None | 0.79A | 2fk8A-4gdjA:undetectable | 2fk8A-4gdjA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i7u | DIHYDRODIPICOLINATESYNTHASE (Agrobacteriumsp. H13-3) |
PF00701(DHDPS) | 3 | SER A 139THR A 147GLN A 112 | None | 0.80A | 2fk8A-4i7uA:undetectable | 2fk8A-4i7uA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jp0 | 43.8 KDAINSECTICIDAL CRYSTALPROTEIN (Bacillusthuringiensis) |
PF05431(Toxin_10) | 3 | SER A 284THR A 235GLN A 239 | None | 0.77A | 2fk8A-4jp0A:undetectable | 2fk8A-4jp0A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8n | PDZ DOMAIN PROTEIN (Parabacteroidesdistasonis) |
PF00595(PDZ)PF13590(DUF4136) | 3 | SER A 38THR A 152GLN A 307 | None | 0.69A | 2fk8A-4l8nA:undetectable | 2fk8A-4l8nA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n2r | ALPHA-L-ARABINOFURANOSIDASE UMABF62A (Ustilago maydis) |
PF03664(Glyco_hydro_62) | 3 | SER A 51THR A 145GLN A 198 | FUB A 402 ( 4.4A)None CA A 401 (-2.9A) | 0.79A | 2fk8A-4n2rA:undetectable | 2fk8A-4n2rA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 3 | SER A 178THR A 205GLN A 92 | 2JG A 176 ( 4.7A)NoneNone | 0.75A | 2fk8A-4na3A:undetectable | 2fk8A-4na3A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhb | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriodesulfuricans) |
PF03480(DctP) | 3 | SER A 211THR A 92GLN A 95 | G3P A 414 ( 4.3A)NoneG3P A 414 (-3.4A) | 0.82A | 2fk8A-4nhbA:undetectable | 2fk8A-4nhbA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5f | TYPE IIIPANTOTHENATE KINASE (Burkholderiathailandensis) |
PF03309(Pan_kinase) | 3 | SER A 154THR A 128GLN A 202 | CL A 305 (-4.9A)NoneNone | 0.85A | 2fk8A-4o5fA:undetectable | 2fk8A-4o5fA:24.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj2 | AQUAPORIN-2 (Homo sapiens) |
PF00230(MIP) | 3 | SER X 188THR X 72GLN X 93 | None | 0.79A | 2fk8A-4oj2X:undetectable | 2fk8A-4oj2X:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppy | PUTATIVEACYLHYDROLASE (Bacteroidesfragilis) |
PF13472(Lipase_GDSL_2) | 3 | SER A 60THR A 120GLN A 90 | None | 0.86A | 2fk8A-4ppyA:2.8 | 2fk8A-4ppyA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us4 | TRANSPORTER (Bacillushalodurans) |
PF00209(SNF) | 3 | SER A 365THR A 356GLN A 153 | None | 0.82A | 2fk8A-4us4A:undetectable | 2fk8A-4us4A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xa2 | MALTOSE-BINDINGPERIPLASMICPROTEIN,MBP-PILA: C (Acinetobacterbaumannii;Escherichiacoli) |
PF00114(Pilin)PF13416(SBP_bac_8) | 3 | SER A 73THR A1096GLN A1025 | None | 0.75A | 2fk8A-4xa2A:undetectable | 2fk8A-4xa2A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zda | ISOCITRATEDEHYDROGENASE (NADP)ICD2 (Mycolicibacteriumsmegmatis) |
PF03971(IDH) | 3 | SER A 662THR A 654GLN A 709 | None | 0.84A | 2fk8A-4zdaA:undetectable | 2fk8A-4zdaA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv7 | LIPASE B (Moesziomycesantarcticus) |
no annotation | 3 | SER A 202THR A 40GLN A 157 | None | 0.77A | 2fk8A-4zv7A:undetectable | 2fk8A-4zv7A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 5 (Homo sapiens;Homo sapiens) |
PF12859(ANAPC1)PF12862(ANAPC5) | 3 | SER A1772THR A1758GLN O 639 | None | 0.79A | 2fk8A-5a31A:undetectable | 2fk8A-5a31A:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 3 | SER A 647THR A 217GLN A 657 | None | 0.75A | 2fk8A-5az4A:undetectable | 2fk8A-5az4A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnt | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Pseudomonasaeruginosa) |
no annotation | 3 | SER C 15THR C 37GLN C 73 | NoneNAP C 500 (-3.0A)NAP C 500 (-3.2A) | 0.69A | 2fk8A-5bntC:undetectable | 2fk8A-5bntC:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djw | ALPHA-GLUCOSIDASE II (Bacteroidesthetaiotaomicron) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 3 | SER A 416THR A 384GLN A 101 | None | 0.74A | 2fk8A-5djwA:undetectable | 2fk8A-5djwA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dl7 | PORIN (Acinetobacterbaumannii) |
PF03573(OprD) | 3 | SER A 298THR A 118GLN A 210 | None | 0.80A | 2fk8A-5dl7A:undetectable | 2fk8A-5dl7A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikl | GERANYL-COACARBOXYLASE,BETA-SUBUNIT (Pseudomonasaeruginosa) |
PF01039(Carboxyl_trans) | 3 | SER B 186THR B 143GLN B 194 | None | 0.85A | 2fk8A-5iklB:undetectable | 2fk8A-5iklB:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5d | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Mycobacteriumtuberculosis) |
PF00701(DHDPS) | 3 | SER A 149THR A 157GLN A 122 | None | 0.79A | 2fk8A-5j5dA:undetectable | 2fk8A-5j5dA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kpg | PAVINEN-METHYLTRANSFERASE (Thalictrumflavum) |
PF02353(CMAS) | 3 | SER A 97THR A 158GLN A 163 | SAH A 401 (-2.5A)NoneSAH A 401 (-3.5A) | 0.43A | 2fk8A-5kpgA:26.7 | 2fk8A-5kpgA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n72 | WIPA (Legionellapneumophila) |
no annotation | 3 | SER A 137THR A 93GLN A 89 | None | 0.81A | 2fk8A-5n72A:undetectable | 2fk8A-5n72A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncs | SERPIN (Tannerellaforsythia) |
PF00079(Serpin) | 3 | SER A 212THR A 207GLN A 234 | None | 0.81A | 2fk8A-5ncsA:undetectable | 2fk8A-5ncsA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncw | SERPIN-TYPEPROTEINASEINHIBITOR, MIROPIN (Tannerellaforsythia) |
PF00079(Serpin) | 3 | SER A 173THR A 168GLN A 195 | None | 0.64A | 2fk8A-5ncwA:undetectable | 2fk8A-5ncwA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odb | D10 FAB FRAGMENT -HEAVY CHAIND10 FAB FRAGMENT -LIGHT CHAIN (Homo sapiens;Homo sapiens) |
no annotationno annotation | 3 | SER A 189THR B 180GLN A 182 | None | 0.60A | 2fk8A-5odbA:undetectable | 2fk8A-5odbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oe5 | ANTHRANILATE--COALIGASE (Pseudomonasaeruginosa) |
PF00501(AMP-binding) | 3 | SER A 216THR A 304GLN A 162 | None3UK A 900 (-3.7A)3UK A 900 ( 4.8A) | 0.79A | 2fk8A-5oe5A:undetectable | 2fk8A-5oe5A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u63 | THIOREDOXINREDUCTASE (Haemophilusinfluenzae) |
PF07992(Pyr_redox_2) | 3 | SER A 134THR A 45GLN A 39 | None | 0.79A | 2fk8A-5u63A:undetectable | 2fk8A-5u63A:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuj | ALKZ (Streptomycessahachiroi) |
PF06224(HTH_42) | 3 | SER A 307THR A 78GLN A 37 | None | 0.80A | 2fk8A-5uujA:undetectable | 2fk8A-5uujA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vpu | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Acinetobacterbaumannii) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 3 | SER A 456THR A 464GLN A 450 | None | 0.79A | 2fk8A-5vpuA:3.1 | 2fk8A-5vpuA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x09 | V-TYPE ATP SYNTHASEALPHA CHAIN,V-TYPEATP SYNTHASE ALPHACHAIN (Pyrococcushorikoshii) |
no annotation | 3 | SER A 251THR A 220GLN A 520 | None | 0.67A | 2fk8A-5x09A:undetectable | 2fk8A-5x09A:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmm | MHC CLASS I ANTIGENALPHA CHAINBETA-2-MICROGLOBULIN (Felis catus;Felis catus) |
no annotationno annotation | 3 | SER A 93THR B 86GLN B 3 | None | 0.79A | 2fk8A-5xmmA:undetectable | 2fk8A-5xmmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6q | ALDEHYDE OXIDASELARGE SUBUNIT (Methylobacillussp. KY4400) |
no annotation | 3 | SER C 328THR C 344GLN C 324 | None | 0.81A | 2fk8A-5y6qC:undetectable | 2fk8A-5y6qC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3b | APRAMETHYLTRANSFERASE 1 (Mooreabouillonii) |
no annotation | 3 | SER A 447THR A 202GLN A 248 | NoneMLI A 703 ( 4.6A)GOL A 704 ( 4.7A) | 0.80A | 2fk8A-6b3bA:12.2 | 2fk8A-6b3bA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bld | CYTOCHROME P450268A2 CYP268A2 (Mycobacteriummarinum) |
no annotation | 3 | SER A 167THR A 265GLN A 381 | NoneHEM A 501 (-3.8A)HEM A 501 (-4.2A) | 0.77A | 2fk8A-6bldA:undetectable | 2fk8A-6bldA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqc | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE (Escherichiacoli) |
no annotation | 3 | SER A 138THR A 197GLN A 202 | CO3 A 401 (-4.5A)NoneNone | 0.38A | 2fk8A-6bqcA:32.2 | 2fk8A-6bqcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ckq | TRANSCRIPTIONANTITERMINATIONPROTEIN NUSB (Burkholderiathailandensis) |
no annotation | 3 | SER A 27THR A 93GLN A 37 | None | 0.81A | 2fk8A-6ckqA:undetectable | 2fk8A-6ckqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ei1 | ZINC FINGER WITHUFM1-SPECIFICPEPTIDASE DOMAINPROTEIN (Homo sapiens) |
no annotation | 3 | SER A 351THR A 420GLN A 394 | None | 0.80A | 2fk8A-6ei1A:undetectable | 2fk8A-6ei1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6es9 | ACYL-COADEHYDROGENASE (Paracoccusdenitrificans) |
no annotation | 3 | SER A 474THR A 236GLN A 417 | None | 0.86A | 2fk8A-6es9A:undetectable | 2fk8A-6es9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f74 | ALCOHOL OXIDASE (Thermothelomycesthermophila) |
no annotation | 3 | SER A 299THR A 189GLN A 185 | None | 0.85A | 2fk8A-6f74A:undetectable | 2fk8A-6f74A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gkv | COCLAURINEN-METHYLTRANSFERASE (Coptis japonica) |
no annotation | 3 | SER A 99THR A 160GLN A 165 | SAH A 501 (-2.4A)SAH A 501 ( 4.8A)SAH A 501 (-2.7A) | 0.38A | 2fk8A-6gkvA:26.1 | 2fk8A-6gkvA:undetectable |