SIMILAR PATTERNS OF AMINO ACIDS FOR 2FK8_A_SAMA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)


(Humicola
insolens)
PF01341
(Glyco_hydro_6)
3 SER A 107
THR A 151
GLN A 136
None
0.81A 2fk8A-1bvwA:
undetectable
2fk8A-1bvwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus)
PF00210
(Ferritin)
3 SER A  48
THR A  86
GLN A  32
None
0.76A 2fk8A-1jgcA:
undetectable
2fk8A-1jgcA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
3 SER A  34
THR A  94
GLN A  99
SAH  A1900 ( 3.6A)
SAH  A1900 (-4.0A)
SAH  A1900 (-2.9A)
0.22A 2fk8A-1kphA:
40.6
2fk8A-1kphA:
54.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
3 SER A  42
THR A 102
GLN A 107
SAH  A 900 ( 2.8A)
SAH  A 900 (-4.0A)
SAH  A 900 (-2.9A)
0.32A 2fk8A-1kpiA:
36.9
2fk8A-1kpiA:
47.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l1e MYCOLIC ACID
SYNTHASE


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
3 SER A  34
THR A  94
GLN A  99
SAH  A 900 ( 2.7A)
SAH  A 900 (-4.4A)
SAH  A 900 (-3.1A)
0.16A 2fk8A-1l1eA:
39.9
2fk8A-1l1eA:
51.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN


(Gallus gallus;
Gallus gallus)
PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
3 SER B 179
THR A 187
GLN A 183
None
0.80A 2fk8A-1m1jB:
undetectable
2fk8A-1m1jB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Haemophilus
influenzae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 SER A  15
THR A  37
GLN A  74
None
NAP  A1372 (-2.9A)
NAP  A1372 (-3.0A)
0.74A 2fk8A-1pquA:
undetectable
2fk8A-1pquA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
3 SER A  34
THR A  94
GLN A  99
SAH  A1900 ( 2.7A)
SAH  A1900 (-4.1A)
SAH  A1900 (-3.0A)
0.17A 2fk8A-1tpyA:
39.7
2fk8A-1tpyA:
51.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1trl THERMOLYSIN FRAGMENT
255 - 316


(Bacillus
thermoproteolyticus)
PF02868
(Peptidase_M4_C)
3 SER A 291
THR A 276
GLN A 283
None
0.78A 2fk8A-1trlA:
undetectable
2fk8A-1trlA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE


(Streptococcus
pneumoniae)
PF00881
(Nitroreductase)
3 SER A 150
THR A  28
GLN A 146
None
0.81A 2fk8A-2b67A:
undetectable
2fk8A-2b67A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D


(Caenorhabditis
elegans)
PF00069
(Pkinase)
3 SER A  10
THR A  46
GLN A  80
None
0.82A 2fk8A-2bdwA:
undetectable
2fk8A-2bdwA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN


(Torpedo
marmorata;
Torpedo
marmorata)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
3 SER A 302
THR A 244
GLN E 249
None
0.82A 2fk8A-2bg9A:
undetectable
2fk8A-2bg9A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
3 SER A  43
THR A 103
GLN A 108
None
0.19A 2fk8A-2fk7A:
44.8
2fk8A-2fk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE


(Streptococcus
pneumoniae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 SER A 250
THR A 302
GLN A 132
None
0.81A 2fk8A-2gz3A:
undetectable
2fk8A-2gz3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C


(Toxoplasma
gondii)
PF00481
(PP2C)
3 SER A 145
THR A  35
GLN A  43
None
0.66A 2fk8A-2i44A:
undetectable
2fk8A-2i44A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE


(Legionella
pneumophila)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
3 SER A 227
THR A  51
GLN A  26
NAD  A 501 ( 4.5A)
None
None
0.65A 2fk8A-2ph5A:
undetectable
2fk8A-2ph5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE


(Xanthomonas
campestris)
PF13419
(HAD_2)
3 SER A 147
THR A 133
GLN A 140
None
None
CL  A 301 (-4.1A)
0.83A 2fk8A-2pkeA:
undetectable
2fk8A-2pkeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)


(Candida
albicans)
PF01380
(SIS)
3 SER A 688
THR A 508
GLN A 361
None
0.80A 2fk8A-2putA:
undetectable
2fk8A-2putA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE


(Shewanella
frigidimarina)
PF04820
(Trp_halogenase)
3 SER A 155
THR A 147
GLN A  89
None
0.67A 2fk8A-2pyxA:
2.8
2fk8A-2pyxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
10)
PF00500
(Late_protein_L1)
3 SER A 468
THR A  30
GLN A 373
None
0.78A 2fk8A-2r5kA:
undetectable
2fk8A-2r5kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE


(Sinorhizobium
meliloti)
PF00701
(DHDPS)
3 SER A 138
THR A 146
GLN A 111
None
0.78A 2fk8A-2vc6A:
undetectable
2fk8A-2vc6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82


(Saccharomyces
cerevisiae)
no annotation 3 SER B 316
THR B  12
GLN B 368
None
0.83A 2fk8A-2vduB:
undetectable
2fk8A-2vduB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER


(Escherichia
coli)
PF02028
(BCCT)
3 SER A 173
THR A 429
GLN A 330
None
0.85A 2fk8A-2wsxA:
undetectable
2fk8A-2wsxA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE


(Thermus
thermophilus)
PF03241
(HpaB)
PF11794
(HpaB_N)
3 SER A 101
THR A  59
GLN A  49
None
0.86A 2fk8A-2yylA:
undetectable
2fk8A-2yylA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X
PENICILLIN-BINDING
PROTEIN 2X


(Streptococcus
pneumoniae;
Streptococcus
pneumoniae)
PF03717
(PBP_dimer)
PF00905
(Transpeptidase)
3 SER A 196
THR B 588
GLN B 458
None
0.58A 2fk8A-2z2mA:
undetectable
2fk8A-2z2mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Pyrococcus
horikoshii)
PF01676
(Metalloenzyme)
PF10143
(PhosphMutase)
3 SER A 357
THR A 344
GLN A  49
None
0.70A 2fk8A-2zktA:
undetectable
2fk8A-2zktA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT


(Thermus
thermophilus)
PF00344
(SecY)
3 SER Y  63
THR Y  36
GLN Y 161
None
0.65A 2fk8A-2zqpY:
undetectable
2fk8A-2zqpY:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE


(Arthrobacter
sp. KI72)
PF01425
(Amidase)
3 SER A 416
THR A 343
GLN A 126
None
0.67A 2fk8A-3a2qA:
undetectable
2fk8A-3a2qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE


(Corynebacterium
glutamicum)
PF00701
(DHDPS)
3 SER A 154
THR A 162
GLN A 127
None
0.78A 2fk8A-3cprA:
undetectable
2fk8A-3cprA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE


(Bacteroides
thetaiotaomicron)
PF13419
(HAD_2)
3 SER A 140
THR A 126
GLN A 133
None
CL  A 233 ( 4.9A)
None
0.81A 2fk8A-3ddhA:
undetectable
2fk8A-3ddhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
3 SER A 207
THR A 849
GLN A 660
None
0.78A 2fk8A-3egwA:
2.8
2fk8A-3egwA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy6 INTEGRON CASSETTE
PROTEIN


(Vibrio cholerae)
no annotation 3 SER A  50
THR A  69
GLN A  55
None
0.74A 2fk8A-3fy6A:
undetectable
2fk8A-3fy6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides)
PF00210
(Ferritin)
3 SER A  48
THR A  86
GLN A  32
None
0.85A 2fk8A-3gvyA:
undetectable
2fk8A-3gvyA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II


(Ruegeria
pomeroyi)
PF00155
(Aminotran_1_2)
3 SER A 199
THR A 176
GLN A 151
None
None
GOL  A 502 (-3.2A)
0.77A 2fk8A-3h14A:
3.8
2fk8A-3h14A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE


(Bacillus
anthracis)
PF00701
(DHDPS)
3 SER A 141
THR A 149
GLN A 114
None
0.78A 2fk8A-3hijA:
undetectable
2fk8A-3hijA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE


(Aspergillus
parasiticus)
PF14765
(PS-DH)
3 SER A1356
THR A1309
GLN A1364
None
0.85A 2fk8A-3hrrA:
undetectable
2fk8A-3hrrA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE


(Bacillus
subtilis)
PF01593
(Amino_oxidase)
3 SER A 188
THR A 441
GLN A 456
None
0.83A 2fk8A-3i6dA:
2.1
2fk8A-3i6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis)
PF00704
(Glyco_hydro_18)
3 SER A 239
THR A 266
GLN A 262
None
0.76A 2fk8A-3ianA:
undetectable
2fk8A-3ianA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis)
PF00923
(TAL_FSA)
3 SER A 249
THR A 186
GLN A 236
None
0.86A 2fk8A-3igxA:
undetectable
2fk8A-3igxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
3 SER A 126
THR A 190
GLN A 403
None
0.60A 2fk8A-3n58A:
2.9
2fk8A-3n58A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956


(Vibrio
parahaemolyticus)
no annotation 3 SER A 495
THR A 244
GLN A 242
None
0.83A 2fk8A-3nlcA:
2.2
2fk8A-3nlcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B)
PF00740
(Parvo_coat)
3 SER A 501
THR A 472
GLN A 507
None
0.83A 2fk8A-3nttA:
undetectable
2fk8A-3nttA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium)
PF02435
(Glyco_hydro_68)
3 SER A 144
THR A 480
GLN A 113
None
0.58A 2fk8A-3om5A:
undetectable
2fk8A-3om5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 SER A  14
THR A  36
GLN A  72
None
NAP  A 372 (-3.1A)
NAP  A 372 (-3.6A)
0.74A 2fk8A-3pzrA:
undetectable
2fk8A-3pzrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF06824
(Glyco_hydro_125)
3 SER A 104
THR A  40
GLN A  67
None
0.67A 2fk8A-3qpfA:
undetectable
2fk8A-3qpfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus)
PF03566
(Peptidase_A21)
3 SER A 476
THR A 497
GLN A 277
None
0.79A 2fk8A-3s6pA:
undetectable
2fk8A-3s6pA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE


(Bartonella
henselae)
PF00701
(DHDPS)
3 SER A 143
THR A 151
GLN A 116
None
EDO  A 803 ( 4.0A)
None
0.78A 2fk8A-3si9A:
undetectable
2fk8A-3si9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]


(Francisella
tularensis)
PF01380
(SIS)
3 SER A 588
THR A 408
GLN A 261
None
0.79A 2fk8A-3tbfA:
2.1
2fk8A-3tbfA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1


(Homo sapiens)
PF00079
(Serpin)
3 SER A 182
THR A 177
GLN A 204
None
0.85A 2fk8A-3ut3A:
undetectable
2fk8A-3ut3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Burkholderia
thailandensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 SER A  14
THR A  36
GLN A  72
None
0.81A 2fk8A-3uw3A:
undetectable
2fk8A-3uw3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A


(Enterococcus
hirae)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
3 SER A 249
THR A 218
GLN A 518
None
0.70A 2fk8A-3vr5A:
3.3
2fk8A-3vr5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix)
PF00291
(PALP)
3 SER A 123
THR A 262
GLN A 224
None
PLP  A 401 ( 2.7A)
SEP  A 402 (-3.3A)
0.83A 2fk8A-3vscA:
3.4
2fk8A-3vscA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus)
PF03372
(Exo_endo_phos)
3 SER A   8
THR A  61
GLN A  98
None
0.65A 2fk8A-3w2xA:
undetectable
2fk8A-3w2xA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE


(Streptomyces
coelicolor)
PF03664
(Glyco_hydro_62)
3 SER A 217
THR A 311
GLN A 364
TRS  A 503 ( 4.5A)
None
CA  A 501 (-2.9A)
0.82A 2fk8A-3wmyA:
undetectable
2fk8A-3wmyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE


(Bacillus
circulans)
PF13199
(Glyco_hydro_66)
PF16990
(CBM_35)
3 SER A 152
THR A 588
GLN A 516
None
0.82A 2fk8A-3wnpA:
undetectable
2fk8A-3wnpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE


(Actinidia
chinensis)
PF01761
(DHQ_synthase)
3 SER A 194
THR A 183
GLN A 148
None
NAD  A1381 (-4.9A)
None
0.83A 2fk8A-3zokA:
undetectable
2fk8A-3zokA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
3 SER A1337
THR A 682
GLN A 497
None
0.84A 2fk8A-4bedA:
undetectable
2fk8A-4bedA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum)
PF00224
(PK)
PF02887
(PK_C)
3 SER A  71
THR A 449
GLN A  43
None
0.85A 2fk8A-4drsA:
2.6
2fk8A-4drsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6x GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Catenulispora
acidiphila)
PF00903
(Glyoxalase)
3 SER A  79
THR A 104
GLN A 101
None
0.80A 2fk8A-4g6xA:
undetectable
2fk8A-4g6xA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
3 SER A 179
THR A 279
GLN A 350
None
0.79A 2fk8A-4gdjA:
undetectable
2fk8A-4gdjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE


(Agrobacterium
sp. H13-3)
PF00701
(DHDPS)
3 SER A 139
THR A 147
GLN A 112
None
0.80A 2fk8A-4i7uA:
undetectable
2fk8A-4i7uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF05431
(Toxin_10)
3 SER A 284
THR A 235
GLN A 239
None
0.77A 2fk8A-4jp0A:
undetectable
2fk8A-4jp0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis)
PF00595
(PDZ)
PF13590
(DUF4136)
3 SER A  38
THR A 152
GLN A 307
None
0.69A 2fk8A-4l8nA:
undetectable
2fk8A-4l8nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A


(Ustilago maydis)
PF03664
(Glyco_hydro_62)
3 SER A  51
THR A 145
GLN A 198
FUB  A 402 ( 4.4A)
None
CA  A 401 (-2.9A)
0.79A 2fk8A-4n2rA:
undetectable
2fk8A-4n2rA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
3 SER A 178
THR A 205
GLN A  92
2JG  A 176 ( 4.7A)
None
None
0.75A 2fk8A-4na3A:
undetectable
2fk8A-4na3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
desulfuricans)
PF03480
(DctP)
3 SER A 211
THR A  92
GLN A  95
G3P  A 414 ( 4.3A)
None
G3P  A 414 (-3.4A)
0.82A 2fk8A-4nhbA:
undetectable
2fk8A-4nhbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE


(Burkholderia
thailandensis)
PF03309
(Pan_kinase)
3 SER A 154
THR A 128
GLN A 202
CL  A 305 (-4.9A)
None
None
0.85A 2fk8A-4o5fA:
undetectable
2fk8A-4o5fA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens)
PF00230
(MIP)
3 SER X 188
THR X  72
GLN X  93
None
0.79A 2fk8A-4oj2X:
undetectable
2fk8A-4oj2X:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE


(Bacteroides
fragilis)
PF13472
(Lipase_GDSL_2)
3 SER A  60
THR A 120
GLN A  90
None
0.86A 2fk8A-4ppyA:
2.8
2fk8A-4ppyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans)
PF00209
(SNF)
3 SER A 365
THR A 356
GLN A 153
None
0.82A 2fk8A-4us4A:
undetectable
2fk8A-4us4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C


(Acinetobacter
baumannii;
Escherichia
coli)
PF00114
(Pilin)
PF13416
(SBP_bac_8)
3 SER A  73
THR A1096
GLN A1025
None
0.75A 2fk8A-4xa2A:
undetectable
2fk8A-4xa2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2


(Mycolicibacterium
smegmatis)
PF03971
(IDH)
3 SER A 662
THR A 654
GLN A 709
None
0.84A 2fk8A-4zdaA:
undetectable
2fk8A-4zdaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus)
no annotation 3 SER A 202
THR A  40
GLN A 157
None
0.77A 2fk8A-4zv7A:
undetectable
2fk8A-4zv7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5


(Homo sapiens;
Homo sapiens)
PF12859
(ANAPC1)
PF12862
(ANAPC5)
3 SER A1772
THR A1758
GLN O 639
None
0.79A 2fk8A-5a31A:
undetectable
2fk8A-5a31A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN


(Campylobacter
jejuni)
PF07196
(Flagellin_IN)
PF07559
(FlaE)
3 SER A 647
THR A 217
GLN A 657
None
0.75A 2fk8A-5az4A:
undetectable
2fk8A-5az4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Pseudomonas
aeruginosa)
no annotation 3 SER C  15
THR C  37
GLN C  73
None
NAP  C 500 (-3.0A)
NAP  C 500 (-3.2A)
0.69A 2fk8A-5bntC:
undetectable
2fk8A-5bntC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
3 SER A 416
THR A 384
GLN A 101
None
0.74A 2fk8A-5djwA:
undetectable
2fk8A-5djwA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii)
PF03573
(OprD)
3 SER A 298
THR A 118
GLN A 210
None
0.80A 2fk8A-5dl7A:
undetectable
2fk8A-5dl7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT


(Pseudomonas
aeruginosa)
PF01039
(Carboxyl_trans)
3 SER B 186
THR B 143
GLN B 194
None
0.85A 2fk8A-5iklB:
undetectable
2fk8A-5iklB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Mycobacterium
tuberculosis)
PF00701
(DHDPS)
3 SER A 149
THR A 157
GLN A 122
None
0.79A 2fk8A-5j5dA:
undetectable
2fk8A-5j5dA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE


(Thalictrum
flavum)
PF02353
(CMAS)
3 SER A  97
THR A 158
GLN A 163
SAH  A 401 (-2.5A)
None
SAH  A 401 (-3.5A)
0.43A 2fk8A-5kpgA:
26.7
2fk8A-5kpgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila)
no annotation 3 SER A 137
THR A  93
GLN A  89
None
0.81A 2fk8A-5n72A:
undetectable
2fk8A-5n72A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia)
PF00079
(Serpin)
3 SER A 212
THR A 207
GLN A 234
None
0.81A 2fk8A-5ncsA:
undetectable
2fk8A-5ncsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN


(Tannerella
forsythia)
PF00079
(Serpin)
3 SER A 173
THR A 168
GLN A 195
None
0.64A 2fk8A-5ncwA:
undetectable
2fk8A-5ncwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
3 SER A 189
THR B 180
GLN A 182
None
0.60A 2fk8A-5odbA:
undetectable
2fk8A-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE


(Pseudomonas
aeruginosa)
PF00501
(AMP-binding)
3 SER A 216
THR A 304
GLN A 162
None
3UK  A 900 (-3.7A)
3UK  A 900 ( 4.8A)
0.79A 2fk8A-5oe5A:
undetectable
2fk8A-5oe5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE


(Haemophilus
influenzae)
PF07992
(Pyr_redox_2)
3 SER A 134
THR A  45
GLN A  39
None
0.79A 2fk8A-5u63A:
undetectable
2fk8A-5u63A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi)
PF06224
(HTH_42)
3 SER A 307
THR A  78
GLN A  37
None
0.80A 2fk8A-5uujA:
undetectable
2fk8A-5uujA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Acinetobacter
baumannii)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
3 SER A 456
THR A 464
GLN A 450
None
0.79A 2fk8A-5vpuA:
3.1
2fk8A-5vpuA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN


(Pyrococcus
horikoshii)
no annotation 3 SER A 251
THR A 220
GLN A 520
None
0.67A 2fk8A-5x09A:
undetectable
2fk8A-5x09A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
BETA-2-MICROGLOBULIN


(Felis catus;
Felis catus)
no annotation
no annotation
3 SER A  93
THR B  86
GLN B   3
None
0.79A 2fk8A-5xmmA:
undetectable
2fk8A-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT


(Methylobacillus
sp. KY4400)
no annotation 3 SER C 328
THR C 344
GLN C 324
None
0.81A 2fk8A-5y6qC:
undetectable
2fk8A-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1


(Moorea
bouillonii)
no annotation 3 SER A 447
THR A 202
GLN A 248
None
MLI  A 703 ( 4.6A)
GOL  A 704 ( 4.7A)
0.80A 2fk8A-6b3bA:
12.2
2fk8A-6b3bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2


(Mycobacterium
marinum)
no annotation 3 SER A 167
THR A 265
GLN A 381
None
HEM  A 501 (-3.8A)
HEM  A 501 (-4.2A)
0.77A 2fk8A-6bldA:
undetectable
2fk8A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE


(Escherichia
coli)
no annotation 3 SER A 138
THR A 197
GLN A 202
CO3  A 401 (-4.5A)
None
None
0.38A 2fk8A-6bqcA:
32.2
2fk8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckq TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSB


(Burkholderia
thailandensis)
no annotation 3 SER A  27
THR A  93
GLN A  37
None
0.81A 2fk8A-6ckqA:
undetectable
2fk8A-6ckqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN


(Homo sapiens)
no annotation 3 SER A 351
THR A 420
GLN A 394
None
0.80A 2fk8A-6ei1A:
undetectable
2fk8A-6ei1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE


(Paracoccus
denitrificans)
no annotation 3 SER A 474
THR A 236
GLN A 417
None
0.86A 2fk8A-6es9A:
undetectable
2fk8A-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila)
no annotation 3 SER A 299
THR A 189
GLN A 185
None
0.85A 2fk8A-6f74A:
undetectable
2fk8A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE


(Coptis japonica)
no annotation 3 SER A  99
THR A 160
GLN A 165
SAH  A 501 (-2.4A)
SAH  A 501 ( 4.8A)
SAH  A 501 (-2.7A)
0.38A 2fk8A-6gkvA:
26.1
2fk8A-6gkvA:
undetectable