SIMILAR PATTERNS OF AMINO ACIDS FOR 2FK8_A_SAMA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 ILE A  87
GLY A 269
GLY A  54
ALA A 122
HIS A 123
 None
 0.86A 2fk8A-1dj2A:
undetectable		 2fk8A-1dj2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 THR 1 341
ILE 1 324
GLY 1 166
GLY 1 219
GLY 1 170
 None
 0.94A 2fk8A-1gt91:
2.1		 2fk8A-1gt91:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		5 THR A 357
ILE A 407
GLY A 341
GLY A 359
GLY A 339
 None
 0.97A 2fk8A-1itxA:
undetectable		 2fk8A-1itxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 ILE A 210
GLY A 211
GLY A 244
GLU A 245
ILE A 208
 None
 0.98A 2fk8A-1jcfA:
undetectable		 2fk8A-1jcfA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		6 THR A 424
TYR A 423
ILE A 308
LEU A 265
GLY A 310
HIS A 269
 None
 1.44A 2fk8A-1k9xA:
undetectable		 2fk8A-1k9xA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		11 THR A  32
TYR A  33
GLY A  72
GLY A  74
LEU A  95
GLY A 122
TRP A 123
GLU A 124
ILE A 136
ALA A 138
HIS A 141
 SAH  A1900 (-4.1A)
10A  A1901 ( 3.5A)
SAH  A1900 (-3.1A)
SAH  A1900 (-3.2A)
SAH  A1900 (-4.4A)
SAH  A1900 (-3.2A)
SAH  A1900 (-4.3A)
SAH  A1900 (-2.9A)
SAH  A1900 (-4.2A)
SAH  A1900 (-3.2A)
SAH  A1900 (-4.4A)
 0.43A 2fk8A-1kphA:
40.6		 2fk8A-1kphA:
54.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		11 THR A  40
TYR A  41
ILE A  79
GLY A  80
GLY A  82
LEU A 103
GLY A 130
TRP A 131
GLU A 132
ALA A 146
HIS A 149
 SAH  A 900 (-4.4A)
10A  A 901 ( 3.7A)
None
SAH  A 900 (-3.3A)
SAH  A 900 (-3.1A)
SAH  A 900 (-4.4A)
SAH  A 900 (-3.3A)
SAH  A 900 (-4.5A)
SAH  A 900 (-3.1A)
SAH  A 900 (-3.1A)
SAH  A 900 (-4.3A)
 0.55A 2fk8A-1kpiA:
36.9		 2fk8A-1kpiA:
47.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		12 THR A  32
TYR A  33
ILE A  71
GLY A  72
GLY A  74
LEU A  95
GLY A 122
TRP A 123
GLU A 124
ILE A 136
ALA A 138
HIS A 141
 SAH  A 900 (-4.1A)
None
None
SAH  A 900 (-3.1A)
SAH  A 900 (-3.4A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.2A)
SAH  A 900 (-4.3A)
SAH  A 900 (-3.7A)
SAH  A 900 (-3.9A)
SAH  A 900 (-3.4A)
SAH  A 900 ( 4.8A)
 0.58A 2fk8A-1l1eA:
39.9		 2fk8A-1l1eA:
51.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		5 ILE A  98
GLY A 283
GLY A  66
ALA A 134
HIS A 135
 None
 0.86A 2fk8A-1mf1A:
undetectable		 2fk8A-1mf1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		7 THR A  70
ILE A  31
GLY A  32
GLY A 359
GLY A 371
GLU A 373
ALA A  33
 None
 1.41A 2fk8A-1o94A:
undetectable		 2fk8A-1o94A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 GLY A 220
GLY A 217
LEU A 174
GLY A 225
GLU A 228
 None
 0.96A 2fk8A-1oypA:
undetectable		 2fk8A-1oypA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 ILE A  92
GLY A  93
GLY A  95
ILE A 155
ALA A 157
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.2A)
None
 0.49A 2fk8A-1p91A:
12.1		 2fk8A-1p91A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 385
GLY A 664
GLY A 409
ILE A 460
ALA A 462
 None
 0.90A 2fk8A-1ps9A:
undetectable		 2fk8A-1ps9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 TYR A 300
ILE A 357
GLY A 358
GLY A 302
ILE A 355
 None
 0.85A 2fk8A-1pw4A:
undetectable		 2fk8A-1pw4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		5 GLY A  16
GLY A  19
LEU A  41
GLY A  64
ALA A  88
 NAD  A 360 (-3.4A)
NAD  A 360 (-3.3A)
NAD  A 360 (-4.1A)
None
NAD  A 360 (-3.6A)
 0.85A 2fk8A-1rkxA:
5.7		 2fk8A-1rkxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		5 ILE A 267
GLY A 268
GLY A 115
LEU A  66
ALA A  23
 None
 0.99A 2fk8A-1t8hA:
undetectable		 2fk8A-1t8hA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		12 THR A  32
TYR A  33
ILE A  71
GLY A  72
GLY A  74
LEU A  95
GLY A 122
TRP A 123
GLU A 124
ILE A 136
ALA A 138
HIS A 141
 SAH  A1900 (-4.1A)
16A  A1901 ( 3.5A)
None
SAH  A1900 (-3.2A)
SAH  A1900 (-3.3A)
SAH  A1900 (-4.3A)
SAH  A1900 (-3.1A)
SAH  A1900 (-4.5A)
SAH  A1900 (-3.1A)
SAH  A1900 (-3.6A)
SAH  A1900 (-3.1A)
16A  A1901 ( 4.2A)
 0.52A 2fk8A-1tpyA:
39.7		 2fk8A-1tpyA:
51.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		5 TYR A 196
GLY A 199
LEU A 452
ILE A 381
ALA A 231
 None
 0.96A 2fk8A-1v4gA:
undetectable		 2fk8A-1v4gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 193
GLY A 192
GLY A 190
ILE A 218
ALA A 220
 None
NAD  A 482 (-3.5A)
NAD  A 482 (-3.0A)
None
NAD  A 482 ( 3.7A)
 0.71A 2fk8A-1v59A:
2.7		 2fk8A-1v59A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 GLY A  18
GLY A  21
LEU A  43
GLY A  66
ALA A  90
 APR  A 400 (-3.2A)
APR  A 400 (-3.2A)
APR  A 400 (-4.1A)
None
APR  A 400 (-3.4A)
 0.82A 2fk8A-1wvgA:
5.1		 2fk8A-1wvgA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxl YCGJ PROTEIN

(Bacillus
subtilis) 		PF08241
(Methyltransf_11) 		6 ILE A  19
GLY A  20
GLY A  22
GLU A  70
ALA A  87
HIS A  90
 None
 0.47A 2fk8A-1xxlA:
18.6		 2fk8A-1xxlA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 227
GLY A 224
LEU A 151
GLY A 237
ALA A 223
 None
 0.95A 2fk8A-1y6jA:
4.2		 2fk8A-1y6jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d81 PHB DEPOLYMERASE

(Talaromyces
funiculosus) 		PF10503
(Esterase_phd) 		5 TYR A  68
GLY A  42
GLY A  66
GLY A 249
ALA A  45
 None
 0.90A 2fk8A-2d81A:
undetectable		 2fk8A-2d81A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE
GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli;
Escherichia
coli) 		PF01019
(G_glu_transpept)
PF01019
(G_glu_transpept) 		5 THR B 407
TYR B 408
LEU A 158
GLY A 162
ALA A  76
 None
 1.00A 2fk8A-2e0xB:
undetectable		 2fk8A-2e0xB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		5 ILE A  75
GLY A  76
GLY A  16
GLY A 160
ILE A  73
 None
None
None
None
HEA  A 515 (-4.4A)
 0.70A 2fk8A-2eijA:
undetectable		 2fk8A-2eijA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 GLY A 356
GLY A 338
LEU A 397
GLY A 259
ALA A 358
 None
 0.91A 2fk8A-2eo5A:
undetectable		 2fk8A-2eo5A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		11 THR A  41
TYR A  42
ILE A  80
GLY A  81
GLY A  83
LEU A 104
GLY A 131
TRP A 132
GLU A 133
ILE A 145
ALA A 147
 None
 0.47A 2fk8A-2fk7A:
44.8		 2fk8A-2fk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		9 THR A  86
ILE A  80
GLY A  81
GLY A  83
LEU A 104
GLY A 131
TRP A 132
GLU A 133
ALA A 147
 None
 1.46A 2fk8A-2fk7A:
44.8		 2fk8A-2fk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		5 ILE A 184
GLY A 195
GLY A 223
GLY A 182
ILE A 193
 None
 0.89A 2fk8A-2j1nA:
undetectable		 2fk8A-2j1nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		5 ILE A  90
GLY A  89
LEU A   9
GLY A  64
ALA A 116
 None
 0.76A 2fk8A-2jgrA:
undetectable		 2fk8A-2jgrA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 THR A1581
ILE A1384
GLY A1383
GLY A1381
GLY A1248
ALA A1590
 None
 1.36A 2fk8A-2pffA:
4.9		 2fk8A-2pffA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 ILE A 133
GLY A 134
GLY A 322
GLY A 390
ALA A 362
 None
 1.01A 2fk8A-2qfrA:
undetectable		 2fk8A-2qfrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		5 THR A 288
GLY A 307
LEU A  11
GLY A 143
ALA A 312
 None
 0.97A 2fk8A-2qtyA:
undetectable		 2fk8A-2qtyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 THR A  41
ILE A  18
GLY A  15
GLY A  12
ALA A 205
 EDO  A1958 ( 3.2A)
None
None
FAD  A 600 (-3.0A)
None
 0.88A 2fk8A-2r4jA:
3.1		 2fk8A-2r4jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		5 GLY A 286
GLY A 103
ILE A 113
ALA A 109
HIS A 106
 None
None
None
None
ANP  A1531 (-3.4A)
 0.99A 2fk8A-2vwbA:
undetectable		 2fk8A-2vwbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		6 ILE A 211
LEU A 168
GLY A 167
ILE A 224
ALA A 162
HIS A 163
 None
 1.38A 2fk8A-2xxlA:
undetectable		 2fk8A-2xxlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  13
GLY A  14
GLY A  16
LEU A  41
ALA A  78
 NAD  A 400 (-4.9A)
NAD  A 400 (-3.3A)
NAD  A 400 (-3.3A)
NAD  A 400 (-4.2A)
NAD  A 400 (-4.2A)
 0.92A 2fk8A-3ceaA:
5.4		 2fk8A-3ceaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 THR A 351
TYR A 350
GLY A 204
GLY A 124
HIS A  50
 None
 0.95A 2fk8A-3cj1A:
undetectable		 2fk8A-3cj1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 207
GLY A 205
GLY A 181
GLU A  70
HIS A  48
 NAD  A 400 (-3.4A)
NAD  A 400 (-3.4A)
None
None
NAD  A 400 (-3.8A)
 0.74A 2fk8A-3cosA:
5.9		 2fk8A-3cosA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 ILE A  24
GLY A  25
GLY A  27
ILE A 369
ALA A 228
 FAD  A 609 (-4.6A)
FAD  A 609 ( 4.0A)
FAD  A 609 (-3.4A)
None
FAD  A 609 ( 3.9A)
 0.96A 2fk8A-3da1A:
undetectable		 2fk8A-3da1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		5 THR A 400
ILE A  75
LEU A 172
ILE A  62
ALA A  64
 None
 1.00A 2fk8A-3dknA:
undetectable		 2fk8A-3dknA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 ILE A  40
GLY A  41
GLY A  43
GLU A  85
ILE A 100
HIS A 105
 None
EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
None
None
EDO  A 261 ( 4.6A)
 1.02A 2fk8A-3egeA:
15.2		 2fk8A-3egeA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 ILE A  40
GLY A  41
GLY A  43
ILE A 100
ALA A 102
HIS A 105
 None
EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
None
EDO  A 261 ( 3.8A)
EDO  A 261 ( 4.6A)
 1.01A 2fk8A-3egeA:
15.2		 2fk8A-3egeA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		5 GLY A  50
GLY A  52
LEU A  73
GLU A  98
ALA A 115
 None
 0.73A 2fk8A-3g5lA:
16.1		 2fk8A-3g5lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 THR A  47
TYR A  49
ILE A  14
GLY A  15
GLY A  17
 FAD  A 541 (-3.7A)
None
FAD  A 541 (-4.8A)
FAD  A 541 (-3.3A)
FAD  A 541 (-3.4A)
 0.98A 2fk8A-3gwfA:
undetectable		 2fk8A-3gwfA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  12
GLY A  13
GLY A  15
LEU A  39
ALA A  82
 None
NAD  A 500 ( 4.2A)
NAD  A 500 (-3.3A)
NAD  A 500 (-4.2A)
NAD  A 500 (-3.5A)
 0.88A 2fk8A-3h3jA:
5.7		 2fk8A-3h3jA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2) 		5 TYR C  36
ILE C  24
GLY C  25
GLY C 166
GLU C 168
 None
 0.95A 2fk8A-3j7aC:
undetectable		 2fk8A-3j7aC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  65
GLY A  88
GLY A  67
ALA A  94
HIS A  99
 None
 0.96A 2fk8A-3jynA:
6.9		 2fk8A-3jynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 403
GLY A 663
GLY A 427
ILE A 481
ALA A 483
 None
 0.93A 2fk8A-3k30A:
undetectable		 2fk8A-3k30A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 ILE A 121
GLY A 122
GLY A  92
GLY A 117
ALA A 124
 None
None
None
P1T  A 702 (-4.3A)
None
 1.00A 2fk8A-3pc3A:
3.1		 2fk8A-3pc3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		5 THR A 200
ILE A 278
GLY A 243
ILE A 222
ALA A 220
 None
 0.87A 2fk8A-3q6tA:
undetectable		 2fk8A-3q6tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 GLY B 346
GLY B 383
GLU B 214
ALA B 351
HIS B 380
 None
None
None
None
MHO  A 499 ( 4.6A)
 0.96A 2fk8A-3sqgB:
undetectable		 2fk8A-3sqgB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 GLY A 373
GLY A 369
GLY A 313
ILE A 655
ALA A 375
 None
 0.96A 2fk8A-3ummA:
2.8		 2fk8A-3ummA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 THR A  47
TYR A  49
ILE A  15
GLY A  16
GLY A  18
 FAD  A 551 (-3.3A)
None
None
FAD  A 551 (-3.2A)
FAD  A 551 (-2.9A)
 0.98A 2fk8A-3up4A:
undetectable		 2fk8A-3up4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		5 ILE A  21
GLY A  61
GLY A  54
LEU A  32
ALA A  51
 None
 0.98A 2fk8A-3vseA:
13.3		 2fk8A-3vseA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		5 ILE A 294
GLY A 293
GLY A 144
GLY A 251
ALA A 292
 None
 0.98A 2fk8A-3w1hA:
4.0		 2fk8A-3w1hA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		5 THR A  44
ILE A   6
GLY A   7
GLY A   9
ALA A  36
 FAD  A 401 (-4.0A)
None
FAD  A 401 (-3.1A)
FAD  A 401 (-3.2A)
FAD  A 401 (-3.8A)
 0.97A 2fk8A-3w4kA:
undetectable		 2fk8A-3w4kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		5 THR A 129
GLY A 171
GLY A  77
GLU A 195
ILE A 152
 None
 1.00A 2fk8A-4ac3A:
undetectable		 2fk8A-4ac3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 ILE A 188
GLY A 189
GLY A 158
GLY A 184
ALA A 191
 None
 0.98A 2fk8A-4aecA:
undetectable		 2fk8A-4aecA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C2
SUBUNIT
F1FO ATPASE C1
SUBUNIT

(Acetobacterium
woodii;
Acetobacterium
woodii) 		PF00137
(ATP-synt_C)
PF00137
(ATP-synt_C) 		6 THR J 127
GLY A  22
GLY A  26
GLY A  68
ILE J 123
ALA J 121
 None
 1.09A 2fk8A-4bemJ:
undetectable		 2fk8A-4bemJ:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		5 THR A  52
TYR A  51
GLY A 347
GLY A 349
GLY A 326
 None
 0.97A 2fk8A-4ce7A:
undetectable		 2fk8A-4ce7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 ILE A 506
GLY A 479
GLY A 461
GLY A 504
ILE A 463
 None
None
None
SO4  A1821 ( 4.6A)
None
 0.94A 2fk8A-4ci8A:
undetectable		 2fk8A-4ci8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		5 THR A 276
ILE A 212
GLY A 213
GLY A 215
HIS A 297
 None
 0.92A 2fk8A-4d7eA:
2.2		 2fk8A-4d7eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 THR A 143
GLY A 117
GLY A 241
GLU A  76
ILE A 145
 None
 1.00A 2fk8A-4dbhA:
undetectable		 2fk8A-4dbhA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 GLY A 353
LEU A 359
GLY A 358
ILE A 306
ALA A  71
 None
 0.91A 2fk8A-4dykA:
undetectable		 2fk8A-4dykA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A   6
GLY A   7
GLY A  13
ILE A 117
ALA A  77
 None
 1.00A 2fk8A-4e0bA:
6.1		 2fk8A-4e0bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 ILE A 369
GLY A 370
GLY A 201
GLY A 349
TRP A 377
 None
 1.00A 2fk8A-4i59A:
undetectable		 2fk8A-4i59A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 ILE A 231
GLY A 232
GLY A 234
LEU A 255
HIS A 303
 None
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.0A)
 0.70A 2fk8A-4ineA:
26.3		 2fk8A-4ineA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		5 ILE A  60
GLY A  61
GLY A  63
ALA A 127
HIS A 130
 None
SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
 0.37A 2fk8A-4iv8A:
25.6		 2fk8A-4iv8A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 THR A 352
TYR A 331
GLY A 109
GLY A  95
ILE A 143
 None
 0.83A 2fk8A-4jhzA:
undetectable		 2fk8A-4jhzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		5 ILE A 366
GLY A 367
GLY A 142
ILE A 364
ALA A  37
 None
 0.97A 2fk8A-4k25A:
undetectable		 2fk8A-4k25A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 ILE A 227
GLY A 228
GLY A 230
LEU A 251
HIS A 299
 None
SAH  A 701 (-3.5A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.2A)
 0.63A 2fk8A-4kriA:
26.4		 2fk8A-4kriA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A  11
GLY A  12
GLY A  14
LEU A  38
ALA A  80
 None
None
None
None
MPD  A 404 ( 4.2A)
 0.94A 2fk8A-4m1qA:
5.6		 2fk8A-4m1qA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		5 TYR A  88
GLY A  34
GLY A  90
GLY A  65
ILE A 239
 None
 1.01A 2fk8A-4p48A:
undetectable		 2fk8A-4p48A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 THR A 324
ILE A 289
GLY A 239
GLY A 287
HIS A 234
 None
 0.99A 2fk8A-4q48A:
3.0		 2fk8A-4q48A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 ILE B  54
GLY B  55
GLY B  57
ILE B 117
ALA B 119
 None
SAM  B 301 (-3.7A)
SAM  B 301 (-3.3A)
SAM  B 301 (-4.2A)
SAM  B 301 (-3.5A)
 0.54A 2fk8A-4qtuB:
14.9		 2fk8A-4qtuB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		5 ILE A  62
GLY A  63
GLY A  65
ALA A 129
HIS A 132
 None
SAH  A 302 (-3.7A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
 0.32A 2fk8A-4r6wA:
27.1		 2fk8A-4r6wA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A  36
GLY A  35
GLY A  88
ILE A  56
ALA A  64
 None
 0.99A 2fk8A-4rjkA:
undetectable		 2fk8A-4rjkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 THR A3315
ILE A3265
GLY A3266
LEU A3334
GLY A3340
 None
 0.97A 2fk8A-4tktA:
undetectable		 2fk8A-4tktA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 5 ILE A1695
GLY A1696
GLY A1698
LEU A1720
ALA A1780
 None
 0.67A 2fk8A-4uclA:
7.2		 2fk8A-4uclA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		5 ILE B 457
GLY B  53
GLY B 488
ILE B 459
ALA B 461
 None
ADP  B 600 (-3.6A)
None
None
None
 0.89A 2fk8A-4xcgB:
undetectable		 2fk8A-4xcgB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 THR B  44
ILE B   6
GLY B   7
GLY B   9
ALA B  36
 FAD  B 401 (-3.4A)
None
FAD  B 401 (-3.3A)
FAD  B 401 (-3.3A)
FAD  B 401 (-3.5A)
 0.92A 2fk8A-4yjfB:
undetectable		 2fk8A-4yjfB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC

(Escherichia
coli;
Escherichia
coli) 		PF01458
(UPF0051)
PF00005
(ABC_tran) 		5 ILE A 453
GLY A 452
GLY C  77
LEU C 162
ALA C 105
 None
 0.91A 2fk8A-5awfA:
undetectable		 2fk8A-5awfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE

(Lactobacillus
plantarum) 		PF00291
(PALP) 		5 ILE A  75
GLY A  76
GLY A  46
GLY A  71
ALA A  78
 None
LLP  A  42 ( 3.5A)
LLP  A  42 ( 3.8A)
SO4  A 404 (-3.3A)
None
 0.98A 2fk8A-5b1hA:
3.3		 2fk8A-5b1hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Thermoplasma
acidophilum) 		PF01884
(PcrB) 		5 ILE A 204
GLY A 203
GLY A 177
GLU A 184
ILE A 226
 None
1GP  A 501 (-3.7A)
1GP  A 501 (-3.7A)
None
None
 0.99A 2fk8A-5b69A:
undetectable		 2fk8A-5b69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		5 THR A 238
TYR A 239
GLY A 242
GLY A 224
GLY A 247
 None
 0.85A 2fk8A-5c92A:
undetectable		 2fk8A-5c92A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 5 ILE A 221
GLY A 220
GLY A 218
LEU A 201
GLY A 214
 None
SO4  A 312 (-3.5A)
SO4  A 312 (-3.2A)
None
None
 0.92A 2fk8A-5fsbA:
undetectable		 2fk8A-5fsbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		5 ILE A  84
GLY A  85
GLY A  87
ILE A 152
HIS A 157
 None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
 0.50A 2fk8A-5gm2A:
24.8		 2fk8A-5gm2A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 TYR F  57
ILE F 128
GLY F  91
GLY F 124
ILE F  95
 None
 0.94A 2fk8A-5itzF:
undetectable		 2fk8A-5itzF:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 5 ILE B 274
GLY B 260
GLY B 277
ILE B 265
HIS B 154
 None
 0.92A 2fk8A-5l22B:
undetectable		 2fk8A-5l22B:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 THR A  47
TYR A  49
ILE A  14
GLY A  15
GLY A  17
 FAD  A 601 (-3.2A)
None
FAD  A 601 (-4.6A)
FAD  A 601 (-3.4A)
FAD  A 601 (-3.3A)
 0.93A 2fk8A-5m10A:
undetectable		 2fk8A-5m10A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 TYR C 666
ILE C 737
GLY C 700
GLY C 733
ILE C 704
 None
 0.93A 2fk8A-5mioC:
undetectable		 2fk8A-5mioC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 GLY A 155
GLY A 554
GLY A 179
ILE A 325
ALA A 327
 None
 1.00A 2fk8A-5odrA:
undetectable		 2fk8A-5odrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 THR B 121
ILE B  90
GLY B  91
GLY B  93
GLY B 111
 FAD  B 601 (-3.5A)
FAD  B 601 (-4.9A)
FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
None
 0.87A 2fk8A-5x1yB:
2.5		 2fk8A-5x1yB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 GLY C  43
GLY C 259
GLU C 211
ILE C  48
ALA C  51
 None
 1.00A 2fk8A-5y6qC:
undetectable		 2fk8A-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 5 ILE A 203
GLY A 180
GLY A 186
GLY A 205
ILE A 246
 None
 0.99A 2fk8A-5yatA:
7.5		 2fk8A-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbn DARPIN

(Escherichia
coli) 		no annotation 5 TYR P  57
ILE P 128
GLY P  91
GLY P 124
ILE P  95
 None
 0.94A 2fk8A-6bbnP:
undetectable		 2fk8A-6bbnP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 5 TYR A 137
ILE A 174
GLY A 175
GLY A 177
HIS A 240
 LOP  A 402 (-2.8A)
None
None
None
LOP  A 402 (-3.2A)
 0.77A 2fk8A-6bqcA:
32.2		 2fk8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 5 ILE A  11
GLY A  12
GLY A  15
GLY A  62
ALA A  84
 None
NAP  A 401 (-3.4A)
NAP  A 401 (-3.5A)
None
NAP  A 401 (-3.5A)
 0.92A 2fk8A-6bwcA:
6.3		 2fk8A-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu0 TRANSCRIPTION FACTOR
IIIB 70 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		no annotation 5 ILE Z 228
GLY Z 225
GLY Z 222
LEU Z 259
HIS Z 241
 None
 0.98A 2fk8A-6eu0Z:
undetectable		 2fk8A-6eu0Z:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvw PROTEIN
(CELLOBIOHYDROLASE
II)

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		3 SER A 107
THR A 151
GLN A 136
 None
 0.81A 2fk8A-1bvwA:
undetectable		 2fk8A-1bvwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		3 SER A  48
THR A  86
GLN A  32
 None
 0.76A 2fk8A-1jgcA:
undetectable		 2fk8A-1jgcA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 SER A  34
THR A  94
GLN A  99
 SAH  A1900 ( 3.6A)
SAH  A1900 (-4.0A)
SAH  A1900 (-2.9A)
 0.22A 2fk8A-1kphA:
40.6		 2fk8A-1kphA:
54.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 SER A  42
THR A 102
GLN A 107
 SAH  A 900 ( 2.8A)
SAH  A 900 (-4.0A)
SAH  A 900 (-2.9A)
 0.32A 2fk8A-1kpiA:
36.9		 2fk8A-1kpiA:
47.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 SER A  34
THR A  94
GLN A  99
 SAH  A 900 ( 2.7A)
SAH  A 900 (-4.4A)
SAH  A 900 (-3.1A)
 0.16A 2fk8A-1l1eA:
39.9		 2fk8A-1l1eA:
51.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 SER B 179
THR A 187
GLN A 183
 None
 0.80A 2fk8A-1m1jB:
undetectable		 2fk8A-1m1jB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A  15
THR A  37
GLN A  74
 None
NAP  A1372 (-2.9A)
NAP  A1372 (-3.0A)
 0.74A 2fk8A-1pquA:
undetectable		 2fk8A-1pquA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 SER A  34
THR A  94
GLN A  99
 SAH  A1900 ( 2.7A)
SAH  A1900 (-4.1A)
SAH  A1900 (-3.0A)
 0.17A 2fk8A-1tpyA:
39.7		 2fk8A-1tpyA:
51.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1trl THERMOLYSIN FRAGMENT
255 - 316

(Bacillus
thermoproteolyticus) 		PF02868
(Peptidase_M4_C) 		3 SER A 291
THR A 276
GLN A 283
 None
 0.78A 2fk8A-1trlA:
undetectable		 2fk8A-1trlA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b67 COG0778:
NITROREDUCTASE

(Streptococcus
pneumoniae) 		PF00881
(Nitroreductase) 		3 SER A 150
THR A  28
GLN A 146
 None
 0.81A 2fk8A-2b67A:
undetectable		 2fk8A-2b67A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		3 SER A  10
THR A  46
GLN A  80
 None
 0.82A 2fk8A-2bdwA:
undetectable		 2fk8A-2bdwA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 SER A 302
THR A 244
GLN E 249
 None
 0.82A 2fk8A-2bg9A:
undetectable		 2fk8A-2bg9A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 SER A  43
THR A 103
GLN A 108
 None
 0.19A 2fk8A-2fk7A:
44.8		 2fk8A-2fk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 250
THR A 302
GLN A 132
 None
 0.81A 2fk8A-2gz3A:
undetectable		 2fk8A-2gz3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 SER A 145
THR A  35
GLN A  43
 None
 0.66A 2fk8A-2i44A:
undetectable		 2fk8A-2i44A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 SER A 227
THR A  51
GLN A  26
 NAD  A 501 ( 4.5A)
None
None
 0.65A 2fk8A-2ph5A:
undetectable		 2fk8A-2ph5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pke HALOACID
DELAHOGENASE-LIKE
FAMILY HYDROLASE

(Xanthomonas
campestris) 		PF13419
(HAD_2) 		3 SER A 147
THR A 133
GLN A 140
 None
None
CL  A 301 (-4.1A)
 0.83A 2fk8A-2pkeA:
undetectable		 2fk8A-2pkeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		3 SER A 688
THR A 508
GLN A 361
 None
 0.80A 2fk8A-2putA:
undetectable		 2fk8A-2putA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 155
THR A 147
GLN A  89
 None
 0.67A 2fk8A-2pyxA:
2.8		 2fk8A-2pyxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		3 SER A 468
THR A  30
GLN A 373
 None
 0.78A 2fk8A-2r5kA:
undetectable		 2fk8A-2r5kA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		3 SER A 138
THR A 146
GLN A 111
 None
 0.78A 2fk8A-2vc6A:
undetectable		 2fk8A-2vc6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 3 SER B 316
THR B  12
GLN B 368
 None
 0.83A 2fk8A-2vduB:
undetectable		 2fk8A-2vduB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		3 SER A 173
THR A 429
GLN A 330
 None
 0.85A 2fk8A-2wsxA:
undetectable		 2fk8A-2wsxA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 SER A 101
THR A  59
GLN A  49
 None
 0.86A 2fk8A-2yylA:
undetectable		 2fk8A-2yylA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		PF03717
(PBP_dimer)
PF00905
(Transpeptidase) 		3 SER A 196
THR B 588
GLN B 458
 None
 0.58A 2fk8A-2z2mA:
undetectable		 2fk8A-2z2mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		3 SER A 357
THR A 344
GLN A  49
 None
 0.70A 2fk8A-2zktA:
undetectable		 2fk8A-2zktA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		3 SER Y  63
THR Y  36
GLN Y 161
 None
 0.65A 2fk8A-2zqpY:
undetectable		 2fk8A-2zqpY:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		3 SER A 416
THR A 343
GLN A 126
 None
 0.67A 2fk8A-3a2qA:
undetectable		 2fk8A-3a2qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		3 SER A 154
THR A 162
GLN A 127
 None
 0.78A 2fk8A-3cprA:
undetectable		 2fk8A-3cprA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		3 SER A 140
THR A 126
GLN A 133
 None
CL  A 233 ( 4.9A)
None
 0.81A 2fk8A-3ddhA:
undetectable		 2fk8A-3ddhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 SER A 207
THR A 849
GLN A 660
 None
 0.78A 2fk8A-3egwA:
2.8		 2fk8A-3egwA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy6 INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		no annotation 3 SER A  50
THR A  69
GLN A  55
 None
 0.74A 2fk8A-3fy6A:
undetectable		 2fk8A-3fy6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides) 		PF00210
(Ferritin) 		3 SER A  48
THR A  86
GLN A  32
 None
 0.85A 2fk8A-3gvyA:
undetectable		 2fk8A-3gvyA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		3 SER A 199
THR A 176
GLN A 151
 None
None
GOL  A 502 (-3.2A)
 0.77A 2fk8A-3h14A:
3.8		 2fk8A-3h14A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		3 SER A 141
THR A 149
GLN A 114
 None
 0.78A 2fk8A-3hijA:
undetectable		 2fk8A-3hijA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		3 SER A1356
THR A1309
GLN A1364
 None
 0.85A 2fk8A-3hrrA:
undetectable		 2fk8A-3hrrA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		3 SER A 188
THR A 441
GLN A 456
 None
 0.83A 2fk8A-3i6dA:
2.1		 2fk8A-3i6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		3 SER A 239
THR A 266
GLN A 262
 None
 0.76A 2fk8A-3ianA:
undetectable		 2fk8A-3ianA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		3 SER A 249
THR A 186
GLN A 236
 None
 0.86A 2fk8A-3igxA:
undetectable		 2fk8A-3igxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 SER A 126
THR A 190
GLN A 403
 None
 0.60A 2fk8A-3n58A:
2.9		 2fk8A-3n58A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 3 SER A 495
THR A 244
GLN A 242
 None
 0.83A 2fk8A-3nlcA:
2.2		 2fk8A-3nlcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		3 SER A 501
THR A 472
GLN A 507
 None
 0.83A 2fk8A-3nttA:
undetectable		 2fk8A-3nttA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		3 SER A 144
THR A 480
GLN A 113
 None
 0.58A 2fk8A-3om5A:
undetectable		 2fk8A-3om5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A  14
THR A  36
GLN A  72
 None
NAP  A 372 (-3.1A)
NAP  A 372 (-3.6A)
 0.74A 2fk8A-3pzrA:
undetectable		 2fk8A-3pzrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		3 SER A 104
THR A  40
GLN A  67
 None
 0.67A 2fk8A-3qpfA:
undetectable		 2fk8A-3qpfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		3 SER A 476
THR A 497
GLN A 277
 None
 0.79A 2fk8A-3s6pA:
undetectable		 2fk8A-3s6pA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		3 SER A 143
THR A 151
GLN A 116
 None
EDO  A 803 ( 4.0A)
None
 0.78A 2fk8A-3si9A:
undetectable		 2fk8A-3si9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		3 SER A 588
THR A 408
GLN A 261
 None
 0.79A 2fk8A-3tbfA:
2.1		 2fk8A-3tbfA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		3 SER A 182
THR A 177
GLN A 204
 None
 0.85A 2fk8A-3ut3A:
undetectable		 2fk8A-3ut3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A  14
THR A  36
GLN A  72
 None
 0.81A 2fk8A-3uw3A:
undetectable		 2fk8A-3uw3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		3 SER A 249
THR A 218
GLN A 518
 None
 0.70A 2fk8A-3vr5A:
3.3		 2fk8A-3vr5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		3 SER A 123
THR A 262
GLN A 224
 None
PLP  A 401 ( 2.7A)
SEP  A 402 (-3.3A)
 0.83A 2fk8A-3vscA:
3.4		 2fk8A-3vscA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		3 SER A   8
THR A  61
GLN A  98
 None
 0.65A 2fk8A-3w2xA:
undetectable		 2fk8A-3w2xA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		3 SER A 217
THR A 311
GLN A 364
 TRS  A 503 ( 4.5A)
None
CA  A 501 (-2.9A)
 0.82A 2fk8A-3wmyA:
undetectable		 2fk8A-3wmyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 SER A 152
THR A 588
GLN A 516
 None
 0.82A 2fk8A-3wnpA:
undetectable		 2fk8A-3wnpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		3 SER A 194
THR A 183
GLN A 148
 None
NAD  A1381 (-4.9A)
None
 0.83A 2fk8A-3zokA:
undetectable		 2fk8A-3zokA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 SER A1337
THR A 682
GLN A 497
 None
 0.84A 2fk8A-4bedA:
undetectable		 2fk8A-4bedA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		3 SER A  71
THR A 449
GLN A  43
 None
 0.85A 2fk8A-4drsA:
2.6		 2fk8A-4drsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6x GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Catenulispora
acidiphila) 		PF00903
(Glyoxalase) 		3 SER A  79
THR A 104
GLN A 101
 None
 0.80A 2fk8A-4g6xA:
undetectable		 2fk8A-4g6xA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 SER A 179
THR A 279
GLN A 350
 None
 0.79A 2fk8A-4gdjA:
undetectable		 2fk8A-4gdjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		3 SER A 139
THR A 147
GLN A 112
 None
 0.80A 2fk8A-4i7uA:
undetectable		 2fk8A-4i7uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		3 SER A 284
THR A 235
GLN A 239
 None
 0.77A 2fk8A-4jp0A:
undetectable		 2fk8A-4jp0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		3 SER A  38
THR A 152
GLN A 307
 None
 0.69A 2fk8A-4l8nA:
undetectable		 2fk8A-4l8nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		3 SER A  51
THR A 145
GLN A 198
 FUB  A 402 ( 4.4A)
None
CA  A 401 (-2.9A)
 0.79A 2fk8A-4n2rA:
undetectable		 2fk8A-4n2rA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 SER A 178
THR A 205
GLN A  92
 2JG  A 176 ( 4.7A)
None
None
 0.75A 2fk8A-4na3A:
undetectable		 2fk8A-4na3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
desulfuricans) 		PF03480
(DctP) 		3 SER A 211
THR A  92
GLN A  95
 G3P  A 414 ( 4.3A)
None
G3P  A 414 (-3.4A)
 0.82A 2fk8A-4nhbA:
undetectable		 2fk8A-4nhbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE

(Burkholderia
thailandensis) 		PF03309
(Pan_kinase) 		3 SER A 154
THR A 128
GLN A 202
 CL  A 305 (-4.9A)
None
None
 0.85A 2fk8A-4o5fA:
undetectable		 2fk8A-4o5fA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		3 SER X 188
THR X  72
GLN X  93
 None
 0.79A 2fk8A-4oj2X:
undetectable		 2fk8A-4oj2X:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE

(Bacteroides
fragilis) 		PF13472
(Lipase_GDSL_2) 		3 SER A  60
THR A 120
GLN A  90
 None
 0.86A 2fk8A-4ppyA:
2.8		 2fk8A-4ppyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		3 SER A 365
THR A 356
GLN A 153
 None
 0.82A 2fk8A-4us4A:
undetectable		 2fk8A-4us4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		3 SER A  73
THR A1096
GLN A1025
 None
 0.75A 2fk8A-4xa2A:
undetectable		 2fk8A-4xa2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		3 SER A 662
THR A 654
GLN A 709
 None
 0.84A 2fk8A-4zdaA:
undetectable		 2fk8A-4zdaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 3 SER A 202
THR A  40
GLN A 157
 None
 0.77A 2fk8A-4zv7A:
undetectable		 2fk8A-4zv7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		3 SER A1772
THR A1758
GLN O 639
 None
 0.79A 2fk8A-5a31A:
undetectable		 2fk8A-5a31A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 SER A 647
THR A 217
GLN A 657
 None
 0.75A 2fk8A-5az4A:
undetectable		 2fk8A-5az4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 3 SER C  15
THR C  37
GLN C  73
 None
NAP  C 500 (-3.0A)
NAP  C 500 (-3.2A)
 0.69A 2fk8A-5bntC:
undetectable		 2fk8A-5bntC:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 SER A 416
THR A 384
GLN A 101
 None
 0.74A 2fk8A-5djwA:
undetectable		 2fk8A-5djwA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 SER A 298
THR A 118
GLN A 210
 None
 0.80A 2fk8A-5dl7A:
undetectable		 2fk8A-5dl7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		3 SER B 186
THR B 143
GLN B 194
 None
 0.85A 2fk8A-5iklB:
undetectable		 2fk8A-5iklB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		3 SER A 149
THR A 157
GLN A 122
 None
 0.79A 2fk8A-5j5dA:
undetectable		 2fk8A-5j5dA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum) 		PF02353
(CMAS) 		3 SER A  97
THR A 158
GLN A 163
 SAH  A 401 (-2.5A)
None
SAH  A 401 (-3.5A)
 0.43A 2fk8A-5kpgA:
26.7		 2fk8A-5kpgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n72 WIPA

(Legionella
pneumophila) 		no annotation 3 SER A 137
THR A  93
GLN A  89
 None
 0.81A 2fk8A-5n72A:
undetectable		 2fk8A-5n72A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		3 SER A 212
THR A 207
GLN A 234
 None
 0.81A 2fk8A-5ncsA:
undetectable		 2fk8A-5ncsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		3 SER A 173
THR A 168
GLN A 195
 None
 0.64A 2fk8A-5ncwA:
undetectable		 2fk8A-5ncwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 SER A 189
THR B 180
GLN A 182
 None
 0.60A 2fk8A-5odbA:
undetectable		 2fk8A-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		3 SER A 216
THR A 304
GLN A 162
 None
3UK  A 900 (-3.7A)
3UK  A 900 ( 4.8A)
 0.79A 2fk8A-5oe5A:
undetectable		 2fk8A-5oe5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		3 SER A 134
THR A  45
GLN A  39
 None
 0.79A 2fk8A-5u63A:
undetectable		 2fk8A-5u63A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		3 SER A 307
THR A  78
GLN A  37
 None
 0.80A 2fk8A-5uujA:
undetectable		 2fk8A-5uujA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 SER A 456
THR A 464
GLN A 450
 None
 0.79A 2fk8A-5vpuA:
3.1		 2fk8A-5vpuA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 3 SER A 251
THR A 220
GLN A 520
 None
 0.67A 2fk8A-5x09A:
undetectable		 2fk8A-5x09A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN
BETA-2-MICROGLOBULIN

(Felis catus;
Felis catus) 		no annotation
no annotation 		3 SER A  93
THR B  86
GLN B   3
 None
 0.79A 2fk8A-5xmmA:
undetectable		 2fk8A-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 3 SER C 328
THR C 344
GLN C 324
 None
 0.81A 2fk8A-5y6qC:
undetectable		 2fk8A-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 3 SER A 447
THR A 202
GLN A 248
 None
MLI  A 703 ( 4.6A)
GOL  A 704 ( 4.7A)
 0.80A 2fk8A-6b3bA:
12.2		 2fk8A-6b3bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2

(Mycobacterium
marinum) 		no annotation 3 SER A 167
THR A 265
GLN A 381
 None
HEM  A 501 (-3.8A)
HEM  A 501 (-4.2A)
 0.77A 2fk8A-6bldA:
undetectable		 2fk8A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 3 SER A 138
THR A 197
GLN A 202
 CO3  A 401 (-4.5A)
None
None
 0.38A 2fk8A-6bqcA:
32.2		 2fk8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckq TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSB

(Burkholderia
thailandensis) 		no annotation 3 SER A  27
THR A  93
GLN A  37
 None
 0.81A 2fk8A-6ckqA:
undetectable		 2fk8A-6ckqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 3 SER A 351
THR A 420
GLN A 394
 None
 0.80A 2fk8A-6ei1A:
undetectable		 2fk8A-6ei1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 3 SER A 474
THR A 236
GLN A 417
 None
 0.86A 2fk8A-6es9A:
undetectable		 2fk8A-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 3 SER A 299
THR A 189
GLN A 185
 None
 0.85A 2fk8A-6f74A:
undetectable		 2fk8A-6f74A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 3 SER A  99
THR A 160
GLN A 165
 SAH  A 501 (-2.4A)
SAH  A 501 ( 4.8A)
SAH  A 501 (-2.7A)
 0.38A 2fk8A-6gkvA:
26.1		 2fk8A-6gkvA:
undetectable