SIMILAR PATTERNS OF AMINO ACIDS FOR 2FJ1_A_CTCA222_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 PHE A 405
PRO A 343
THR A 398
VAL A 419
SER A 412
 None
 1.35A 2fj1A-1gkrA:
undetectable		 2fj1A-1gkrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		5 VAL A 176
GLN A 171
LEU A 166
ILE A 167
SER A 185
 None
 1.13A 2fj1A-1hqsA:
undetectable		 2fj1A-1hqsA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu0 PSD-95

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 SER A  71
THR A  69
VAL A  68
LEU A  58
ILE A  57
 None
 1.25A 2fj1A-1iu0A:
undetectable		 2fj1A-1iu0A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 HIS A  42
PHE A  39
PRO A 145
LEU A  94
ILE A 101
 None
 1.39A 2fj1A-1ocmA:
undetectable		 2fj1A-1ocmA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		9 HIS A  64
SER A  67
PHE A  86
HIS A 100
THR A 112
GLN A 116
LEU A 131
ILE A 134
SER A 138
 None
None
None
IMD  A   1 (-4.0A)
None
None
None
None
None
 0.67A 2fj1A-1qpiA:
25.4		 2fj1A-1qpiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qpi PROTEIN
(TETRACYCLINE
REPRESSOR)

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		9 HIS A  64
SER A  67
PHE A  86
THR A 112
VAL A 113
GLN A 116
LEU A 131
ILE A 134
SER A 138
 None
 0.55A 2fj1A-1qpiA:
25.4		 2fj1A-1qpiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 HIS A 344
SER A 339
ARG A 366
VAL A 301
ILE A 332
 None
 1.25A 2fj1A-1t6pA:
1.5		 2fj1A-1t6pA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 HIS A 223
VAL A  98
LEU A 178
ILE A 204
SER A 200
 4PA  A 701 (-4.4A)
None
None
None
None
 1.32A 2fj1A-1tqhA:
undetectable		 2fj1A-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		5 SER A  67
ARG A 102
PRO A 100
VAL A  71
ILE A  57
 None
 1.37A 2fj1A-1x25A:
undetectable		 2fj1A-1x25A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 HIS A  88
SER A 108
PRO A 154
THR A 148
LEU A 252
 MN  A 502 (-3.6A)
None
None
None
None
 1.49A 2fj1A-2eb0A:
0.3		 2fj1A-2eb0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		5 PHE A 237
HIS A 314
LEU A  77
ILE A  76
SER A 201
 None
 1.33A 2fj1A-2ejaA:
undetectable		 2fj1A-2ejaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 ARG A  70
THR A   5
VAL A  73
LEU A  93
ILE A  76
 None
 1.25A 2fj1A-2eq5A:
undetectable		 2fj1A-2eq5A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		5 PRO A  65
THR A  53
VAL A  67
LEU A  86
ILE A 106
 None
 1.47A 2fj1A-2espA:
undetectable		 2fj1A-2espA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		5 THR A 258
VAL A 257
LEU A 297
ILE A 241
SER A 244
 None
 1.42A 2fj1A-2f8qA:
0.5		 2fj1A-2f8qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fu0 CYCLOPHILIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00160
(Pro_isomerase) 		5 SER A  20
PHE A 123
THR A 127
VAL A 126
ILE A  10
 None
 1.48A 2fj1A-2fu0A:
undetectable		 2fj1A-2fu0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 PHE A  43
VAL A  33
LEU A  27
ILE A  50
SER A  52
 None
 1.42A 2fj1A-2i00A:
undetectable		 2fj1A-2i00A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 HIS A 211
THR A 160
VAL A 161
GLN A 125
ILE A 122
 ZN  A 401 (-3.4A)
ADE  A1114 ( 4.3A)
None
ADE  A1114 (-3.3A)
None
 1.15A 2fj1A-2icsA:
undetectable		 2fj1A-2icsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		5 SER G 100
THR G 115
VAL G 116
LEU G  91
ILE G  54
 None
 1.47A 2fj1A-2iouG:
undetectable		 2fj1A-2iouG:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3e T7I23.11 PROTEIN

(Arabidopsis
thaliana) 		PF04548
(AIG1) 		5 SER A  36
PHE A  26
THR A  38
VAL A  39
LEU A 155
 None
 1.43A 2fj1A-2j3eA:
undetectable		 2fj1A-2j3eA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		5 SER A  69
PHE A  76
ARG A 157
THR A  88
GLN A  91
 None
 1.49A 2fj1A-2k1gA:
undetectable		 2fj1A-2k1gA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdi UBIQUITIN, VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN 27 FUSION
PROTEIN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02809
(UIM) 		5 SER A  66
THR A  64
LEU A  24
ILE A  12
SER A  74
 None
 1.25A 2fj1A-2kdiA:
undetectable		 2fj1A-2kdiA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpb MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 15

(Saccharomyces
cerevisiae) 		no annotation 5 PRO A 191
THR A 200
VAL A 199
LEU A 183
ILE A 186
 None
 1.46A 2fj1A-2lpbA:
undetectable		 2fj1A-2lpbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myu GLUTAREDOXIN
ARSENATE REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF01451
(LMWPc) 		5 PRO A 104
THR A 114
VAL A 115
GLN A 118
LEU A  79
 None
 1.20A 2fj1A-2myuA:
undetectable		 2fj1A-2myuA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv9 A207R PROTEIN,
ARGININE
DECARBOXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A  66
PRO A 253
THR A  42
LEU A  30
ILE A  31
 None
 1.49A 2fj1A-2nv9A:
undetectable		 2fj1A-2nv9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PRO A  16
THR A 379
LEU A 373
ILE A 345
SER A 302
 None
 1.43A 2fj1A-2qdeA:
undetectable		 2fj1A-2qdeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ARG A  68
PRO A 135
VAL A  71
LEU A 411
ILE A 408
 SO4  A 505 (-4.8A)
None
None
None
None
 1.29A 2fj1A-2qyvA:
undetectable		 2fj1A-2qyvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		5 PHE A 312
PRO A 195
THR A 115
VAL A 116
LEU A 124
 None
 1.41A 2fj1A-2rhqA:
undetectable		 2fj1A-2rhqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 ARG A 226
THR A 188
VAL A 189
GLN A 192
LEU A 221
 None
 1.26A 2fj1A-2vn7A:
undetectable		 2fj1A-2vn7A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdv MYC-INDUCED NUCLEAR
ANTIGEN

(Homo sapiens) 		PF08007
(Cupin_4) 		5 SER A 257
PRO A 140
THR A 255
VAL A 254
ILE A 150
 None
None
OGA  A 601 (-3.0A)
None
None
 1.42A 2fj1A-2xdvA:
undetectable		 2fj1A-2xdvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 HIS A 226
PRO A 230
THR A 223
LEU A 530
ILE A 536
 None
 1.11A 2fj1A-2yfnA:
2.4		 2fj1A-2yfnA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 SER A 147
ARG A 366
THR A 376
VAL A 377
ILE A 223
 None
 1.25A 2fj1A-3a1iA:
undetectable		 2fj1A-3a1iA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		5 HIS A  36
SER A  41
HIS A  81
ARG A 208
PRO A 209
 None
 1.36A 2fj1A-3a2lA:
undetectable		 2fj1A-3a2lA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm1 PROTEIN YDJA

(Escherichia
coli) 		PF00881
(Nitroreductase) 		5 PHE A 146
ARG A 132
VAL A 115
LEU A 160
ILE A  90
 None
 1.30A 2fj1A-3bm1A:
undetectable		 2fj1A-3bm1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvc GLYCOPROTEIN GP110

(Human
gammaherpesvirus
4) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		5 SER A 560
THR A 535
VAL A 536
LEU A 572
ILE A 578
 None
 1.36A 2fj1A-3fvcA:
undetectable		 2fj1A-3fvcA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gov MASP-1

(Homo sapiens) 		PF00084
(Sushi) 		5 PRO A 360
THR A 344
VAL A 327
LEU A 304
SER A 356
 None
GOL  A   1 (-4.6A)
None
None
None
 1.46A 2fj1A-3govA:
undetectable		 2fj1A-3govA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 SER A 233
HIS A 104
PRO A 198
LEU A 203
ILE A 237
 None
 1.24A 2fj1A-3hn7A:
undetectable		 2fj1A-3hn7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 5 SER A 292
ARG A  43
VAL A 298
LEU A  85
SER A  49
 None
 1.42A 2fj1A-3i9wA:
4.5		 2fj1A-3i9wA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP3
PROTEIN VP2

(Enterovirus B;
Enterovirus B;
Enterovirus B) 		PF00073
(Rhv)
PF00073
(Rhv)
PF00073
(Rhv) 		5 HIS C 207
PRO C 119
VAL A 187
ILE B  36
SER C 198
 None
 1.46A 2fj1A-3j2jC:
undetectable		 2fj1A-3j2jC:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 HIS A 135
SER A 327
VAL A 107
ILE A 336
SER A 117
 None
 1.44A 2fj1A-3kalA:
undetectable		 2fj1A-3kalA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kij PROBABLE GLUTATHIONE
PEROXIDASE 8

(Homo sapiens) 		PF00255
(GSHPx) 		5 SER A  99
PHE A 101
PRO A 135
LEU A  62
SER A  70
 None
 1.00A 2fj1A-3kijA:
undetectable		 2fj1A-3kijA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj PUTATIVE HISTIDINE
PROTEIN KINASE
CHEY6 PROTEIN

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF01627
(Hpt)
PF00072
(Response_reg) 		5 ARG B  15
VAL A  59
LEU A  14
ILE A  11
SER B  20
 None
 1.09A 2fj1A-3kyjB:
undetectable		 2fj1A-3kyjB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		5 PHE A  91
THR A  85
VAL A  84
LEU A 150
ILE A 124
 None
 1.20A 2fj1A-3l4eA:
undetectable		 2fj1A-3l4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		5 SER A  36
THR A  85
VAL A  84
LEU A 150
ILE A 124
 None
 1.18A 2fj1A-3l4eA:
undetectable		 2fj1A-3l4eA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 SER X  27
THR X  25
VAL X  24
LEU X 156
ILE X 158
 None
 1.44A 2fj1A-3m7mX:
undetectable		 2fj1A-3m7mX:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE

(Mus musculus) 		PF07686
(V-set) 		5 SER A 217
ARG A 183
THR A 215
LEU A 203
ILE A 201
 None
 1.17A 2fj1A-3mj9A:
undetectable		 2fj1A-3mj9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no4 CREATININE
AMIDOHYDROLASE

(Nostoc
punctiforme) 		PF02633
(Creatininase) 		5 ARG A 213
THR A 176
VAL A 173
GLN A 177
LEU A 220
 None
 1.42A 2fj1A-3no4A:
undetectable		 2fj1A-3no4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa3 ALDOLASE

(Coccidioides
immitis) 		PF01791
(DeoC) 		5 SER A 103
ARG A 147
VAL A 108
LEU A 122
ILE A  95
 None
 1.48A 2fj1A-3oa3A:
undetectable		 2fj1A-3oa3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN

(Bordetella
bronchiseptica) 		PF13379
(NMT1_2) 		5 HIS A  95
SER A 148
PRO A 116
THR A 150
VAL A 153
 CIT  A 347 (-4.1A)
CIT  A 347 (-3.6A)
None
CIT  A 347 (-3.2A)
None
 1.43A 2fj1A-3qslA:
undetectable		 2fj1A-3qslA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		5 HIS A 204
ARG A 225
LEU A 250
ILE A 246
SER A 216
 MN  A 365 (-3.4A)
None
None
None
None
 1.31A 2fj1A-3rmjA:
undetectable		 2fj1A-3rmjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		5 HIS A 319
SER A 363
HIS A 193
LEU A  47
ILE A 189
 None
None
MN  A 413 (-3.3A)
None
None
 1.44A 2fj1A-3sl1A:
undetectable		 2fj1A-3sl1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		5 THR A 329
VAL A 297
LEU A 325
ILE A 340
SER A 385
 None
 1.35A 2fj1A-3upuA:
undetectable		 2fj1A-3upuA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 SER A 273
PRO A 252
VAL A 271
ILE A 264
SER A 188
 None
 1.15A 2fj1A-3upyA:
undetectable		 2fj1A-3upyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		5 PRO A  60
THR A 117
VAL A 118
LEU A  23
ILE A 132
 None
 1.40A 2fj1A-3wdgA:
undetectable		 2fj1A-3wdgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqf D-THREO-3-HYDROXYASP
ARTATE DEHYDRATASE

(Delftia sp.
HT23) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 PHE A 339
THR A 315
VAL A 313
LEU A 348
ILE A 347
 None
 1.24A 2fj1A-3wqfA:
undetectable		 2fj1A-3wqfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 PHE A 260
ARG A 254
GLN A 199
LEU A 170
ILE A 249
 None
None
None
GOL  A1642 (-4.9A)
None
 1.46A 2fj1A-3ziuA:
undetectable		 2fj1A-3ziuA:
14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		6 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
 0.85A 2fj1A-4ac0A:
26.4		 2fj1A-4ac0A:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		7 HIS A  64
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
LEU A 131
 MIY  A1204 (-3.8A)
MIY  A1204 (-3.5A)
MG  A1205 ( 3.2A)
MIY  A1204 (-4.4A)
MIY  A1204 ( 4.7A)
MIY  A1204 (-2.8A)
MIY  A1204 (-4.3A)
 0.61A 2fj1A-4ac0A:
26.4		 2fj1A-4ac0A:
65.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00431
(CUB)
PF14670
(FXa_inhibition) 		5 PRO A 360
THR A 344
VAL A 327
LEU A 304
SER A 356
 None
 1.46A 2fj1A-4aqbA:
undetectable		 2fj1A-4aqbA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgo EFEM M75 PEPTIDASE

(Pseudomonas
syringae) 		PF09375
(Peptidase_M75) 		5 ARG A  86
THR A 137
GLN A 141
LEU A 148
ILE A 144
 None
 1.45A 2fj1A-4bgoA:
undetectable		 2fj1A-4bgoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 SER A  34
THR A  36
VAL A  37
LEU A  70
ILE A  72
 None
 1.31A 2fj1A-4bl0A:
undetectable		 2fj1A-4bl0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 PHE A 277
THR A 346
VAL A 347
LEU A 320
ILE A 316
 None
 1.39A 2fj1A-4bocA:
2.1		 2fj1A-4bocA:
11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR

(Proteus
mirabilis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		7 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 None
 0.82A 2fj1A-4d5cA:
26.3		 2fj1A-4d5cA:
59.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		5 PHE A 100
THR A 172
VAL A 173
LEU A 188
ILE A 187
 None
 0.87A 2fj1A-4exqA:
undetectable		 2fj1A-4exqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 PHE A 898
THR A 906
VAL A 905
LEU A 845
ILE A 863
 None
 1.23A 2fj1A-4fysA:
undetectable		 2fj1A-4fysA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 SER M 590
PHE M 406
ARG M 496
THR M 411
ILE M 418
 None
 1.40A 2fj1A-4gq2M:
1.4		 2fj1A-4gq2M:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 HIS A 103
THR A 315
VAL A 314
LEU A 132
ILE A 110
 None
 1.47A 2fj1A-4gx8A:
undetectable		 2fj1A-4gx8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 PRO A 111
GLN A  96
LEU A  51
ILE A  19
SER A  22
 None
 1.37A 2fj1A-4hzcA:
undetectable		 2fj1A-4hzcA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 HIS A 211
ARG A 341
THR A 122
GLN A 123
SER A 164
 None
 1.13A 2fj1A-4m2gA:
undetectable		 2fj1A-4m2gA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7s BTRN

(Bacillus
circulans) 		PF13186
(SPASM) 		5 PHE A 214
THR A 179
VAL A 178
LEU A  48
ILE A 205
 None
 1.34A 2fj1A-4m7sA:
undetectable		 2fj1A-4m7sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oby ARGININE--TRNA
LIGASE

(Escherichia
coli) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ARG A 245
THR A 249
VAL A 248
LEU A 133
ILE A 137
 None
 1.36A 2fj1A-4obyA:
undetectable		 2fj1A-4obyA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 SER A 230
ARG A 208
LEU A 179
ILE A  76
SER A 213
 None
 1.32A 2fj1A-4p4sA:
undetectable		 2fj1A-4p4sA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 SER B 230
ARG B 208
LEU B 179
ILE B  76
SER B 213
 None
 1.31A 2fj1A-4p4sB:
2.5		 2fj1A-4p4sB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae) 		PF01223
(Endonuclease_NS) 		5 SER A 100
THR A 211
VAL A 210
LEU A 154
ILE A 150
 None
 1.27A 2fj1A-4qgoA:
undetectable		 2fj1A-4qgoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		5 PRO A  18
THR A 286
VAL A 287
LEU A  47
ILE A 289
 None
 1.27A 2fj1A-4qqsA:
undetectable		 2fj1A-4qqsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA

(Pseudomonas
aeruginosa) 		PF03162
(Y_phosphatase2) 		5 ARG A  51
THR A  77
VAL A  75
LEU A  69
SER A  59
 None
 1.25A 2fj1A-4r0sA:
undetectable		 2fj1A-4r0sA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 PHE A 405
PRO A 303
VAL A 233
LEU A 168
SER A 205
 None
 1.27A 2fj1A-4xiiA:
undetectable		 2fj1A-4xiiA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1
SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 2

(Daucus carota;
Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF13855
(LRR_8)
PF00560
(LRR_1)
PF08263
(LRRNT_2) 		5 SER A 608
PHE A 606
THR C  67
VAL C  66
LEU C  39
 None
 1.40A 2fj1A-4z61A:
undetectable		 2fj1A-4z61A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		5 HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
 None
 1.45A 2fj1A-4zhtA:
undetectable		 2fj1A-4zhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 SER A 136
THR A 134
VAL A 133
LEU A 300
ILE A 268
 None
 1.25A 2fj1A-4zo6A:
undetectable		 2fj1A-4zo6A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		5 SER A  42
THR A  40
VAL A  39
LEU A  26
ILE A  25
 None
 1.34A 2fj1A-5c17A:
2.1		 2fj1A-5c17A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2n C25 BETA

(Homo sapiens) 		no annotation 5 SER F 109
PHE F 107
ARG F  36
GLN F   6
LEU F  77
 None
 1.31A 2fj1A-5d2nF:
undetectable		 2fj1A-5d2nF:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 SER A 181
HIS A  97
PRO A 135
VAL A 153
ILE A 307
 None
 1.48A 2fj1A-5f4zA:
undetectable		 2fj1A-5f4zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr7 AMYR

(Erwinia
amylovora) 		PF10722
(YbjN) 		5 SER A 130
VAL A 103
LEU A  77
ILE A  80
SER A  83
 None
 1.46A 2fj1A-5fr7A:
undetectable		 2fj1A-5fr7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 SER A 238
GLN A 241
LEU A 248
ILE A 244
SER A 229
 None
 1.34A 2fj1A-5gw7A:
undetectable		 2fj1A-5gw7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		5 SER A 157
THR A 155
LEU A 115
ILE A 103
SER A 165
 None
 1.45A 2fj1A-5h07A:
undetectable		 2fj1A-5h07A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E

(Thalictrum
flavum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 HIS A 256
VAL A 341
GLN A 342
LEU A 172
ILE A 173
 None
 1.35A 2fj1A-5icgA:
undetectable		 2fj1A-5icgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ier OHP9

(synthetic
construct) 		PF02136
(NTF2) 		5 THR A 118
VAL A 111
LEU A   6
ILE A  85
SER A  79
 SO4  A 203 ( 4.2A)
None
None
None
None
 1.42A 2fj1A-5ierA:
undetectable		 2fj1A-5ierA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbg BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc) 		5 SER A 249
PHE A 154
THR A 293
ILE A 216
SER A 219
 None
None
IOD  A 403 ( 4.9A)
None
None
 1.28A 2fj1A-5mbgA:
undetectable		 2fj1A-5mbgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbh BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		5 SER A 249
PHE A 154
THR A 293
ILE A 216
SER A 219
 None
 1.26A 2fj1A-5mbhA:
undetectable		 2fj1A-5mbhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP3
CAPSID SUBUNIT VP0

(Parechovirus A;
Parechovirus A) 		no annotation
PF00073
(Rhv) 		5 SER B  85
PHE C 201
PRO C 250
THR B  87
ILE B 231
 None
 1.38A 2fj1A-5mjvB:
undetectable		 2fj1A-5mjvB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmd METALLO-BETA-LACTAMA
SE 1

(Acinetobacter
baumannii) 		PF00753
(Lactamase_B) 		5 HIS E 116
PRO E 192
VAL E 202
LEU E 283
ILE E 223
 ZN  E 403 (-3.3A)
None
None
None
None
 1.20A 2fj1A-5mmdE:
undetectable		 2fj1A-5mmdE:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mru TETRACYCLINE
REPRESSOR, CLASS A

(Pseudomonas sp.) 		no annotation 7 HIS A  64
PHE A  86
HIS A 100
ARG A 104
PRO A 105
THR A 112
GLN A 116
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.0A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
 0.66A 2fj1A-5mruA:
23.8		 2fj1A-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mru TETRACYCLINE
REPRESSOR, CLASS A

(Pseudomonas sp.) 		no annotation 8 HIS A  64
SER A  67
PHE A  86
HIS A 100
PRO A 105
THR A 112
GLN A 116
SER A 138
 TDC  A 301 (-3.8A)
TDC  A 301 (-3.3A)
TDC  A 301 (-3.3A)
MG  A 302 ( 3.2A)
TDC  A 301 (-4.5A)
None
TDC  A 301 (-2.8A)
TDC  A 301 ( 3.7A)
 0.83A 2fj1A-5mruA:
23.8		 2fj1A-5mruA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 HIS A 401
HIS A 399
ARG A  76
ILE A 233
SER A 225
 None
None
FMT  A 607 (-3.6A)
None
None
 1.16A 2fj1A-5odoA:
undetectable		 2fj1A-5odoA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjj TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Alicyclobacillus
acidocaldarius) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 SER A  56
ARG A  20
LEU A  35
ILE A  31
SER A  26
 None
 1.25A 2fj1A-5tjjA:
2.1		 2fj1A-5tjjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 PHE A 532
PRO A 350
VAL A 308
LEU A 327
ILE A 325
 None
 1.36A 2fj1A-5u3cA:
undetectable		 2fj1A-5u3cA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 SER A 440
THR A 463
VAL A 462
GLN A 466
LEU A 423
 None
 1.43A 2fj1A-5u47A:
undetectable		 2fj1A-5u47A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 PRO A  16
THR A 401
VAL A 310
LEU A  37
ILE A 312
 None
 1.45A 2fj1A-5x7nA:
undetectable		 2fj1A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 494
ARG A 513
LEU A 308
ILE A 307
SER A 462
 None
 1.33A 2fj1A-5xfmA:
undetectable		 2fj1A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 5 HIS A 941
THR A 680
VAL A 677
LEU A 613
ILE A 614
 None
 1.45A 2fj1A-6f42A:
3.5		 2fj1A-6f42A:
undetectable