SIMILAR PATTERNS OF AMINO ACIDS FOR 2FJ1_A_CTCA222
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gkr | NON-ATP DEPENDENTL-SELECTIVEHYDANTOINASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | PHE A 405PRO A 343THR A 398VAL A 419SER A 412 | None | 1.35A | 2fj1A-1gkrA:undetectable | 2fj1A-1gkrA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hqs | ISOCITRATEDEHYDROGENASE (Bacillussubtilis) |
PF00180(Iso_dh) | 5 | VAL A 176GLN A 171LEU A 166ILE A 167SER A 185 | None | 1.13A | 2fj1A-1hqsA:undetectable | 2fj1A-1hqsA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iu0 | PSD-95 (Rattusnorvegicus) |
PF00595(PDZ) | 5 | SER A 71THR A 69VAL A 68LEU A 58ILE A 57 | None | 1.25A | 2fj1A-1iu0A:undetectable | 2fj1A-1iu0A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ocm | MALONAMIDASE E2 (Bradyrhizobiumjaponicum) |
PF01425(Amidase) | 5 | HIS A 42PHE A 39PRO A 145LEU A 94ILE A 101 | None | 1.39A | 2fj1A-1ocmA:undetectable | 2fj1A-1ocmA:21.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 9 | HIS A 64SER A 67PHE A 86HIS A 100THR A 112GLN A 116LEU A 131ILE A 134SER A 138 | NoneNoneNoneIMD A 1 (-4.0A)NoneNoneNoneNoneNone | 0.67A | 2fj1A-1qpiA:25.4 | 2fj1A-1qpiA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qpi | PROTEIN(TETRACYCLINEREPRESSOR) (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 9 | HIS A 64SER A 67PHE A 86THR A 112VAL A 113GLN A 116LEU A 131ILE A 134SER A 138 | None | 0.55A | 2fj1A-1qpiA:25.4 | 2fj1A-1qpiA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 5 | HIS A 344SER A 339ARG A 366VAL A 301ILE A 332 | None | 1.25A | 2fj1A-1t6pA:1.5 | 2fj1A-1t6pA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqh | CARBOXYLESTERASEPRECURSOR (Geobacillusstearothermophilus) |
PF12146(Hydrolase_4) | 5 | HIS A 223VAL A 98LEU A 178ILE A 204SER A 200 | 4PA A 701 (-4.4A)NoneNoneNoneNone | 1.32A | 2fj1A-1tqhA:undetectable | 2fj1A-1tqhA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x25 | HYPOTHETICAL UPF0076PROTEIN ST0811 (Sulfurisphaeratokodaii) |
PF01042(Ribonuc_L-PSP) | 5 | SER A 67ARG A 102PRO A 100VAL A 71ILE A 57 | None | 1.37A | 2fj1A-1x25A:undetectable | 2fj1A-1x25A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb0 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01368(DHH)PF02833(DHHA2) | 5 | HIS A 88SER A 108PRO A 154THR A 148LEU A 252 | MN A 502 (-3.6A)NoneNoneNoneNone | 1.49A | 2fj1A-2eb0A:0.3 | 2fj1A-2eb0A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eja | UROPORPHYRINOGENDECARBOXYLASE (Aquifexaeolicus) |
PF01208(URO-D) | 5 | PHE A 237HIS A 314LEU A 77ILE A 76SER A 201 | None | 1.33A | 2fj1A-2ejaA:undetectable | 2fj1A-2ejaA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eq5 | 228AA LONGHYPOTHETICALHYDANTOIN RACEMASE (Pyrococcushorikoshii) |
PF01177(Asp_Glu_race) | 5 | ARG A 70THR A 5VAL A 73LEU A 93ILE A 76 | None | 1.25A | 2fj1A-2eq5A:undetectable | 2fj1A-2eq5A:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esp | UBIQUITIN-CONJUGATING ENZYME E2 D2 (Homo sapiens) |
PF00179(UQ_con) | 5 | PRO A 65THR A 53VAL A 67LEU A 86ILE A 106 | None | 1.47A | 2fj1A-2espA:undetectable | 2fj1A-2espA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8q | ALKALINETHERMOSTABLEENDOXYLANASE (Bacillus sp.NG-27) |
PF00331(Glyco_hydro_10) | 5 | THR A 258VAL A 257LEU A 297ILE A 241SER A 244 | None | 1.42A | 2fj1A-2f8qA:0.5 | 2fj1A-2f8qA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fu0 | CYCLOPHILIN,PUTATIVE (Plasmodiumfalciparum) |
PF00160(Pro_isomerase) | 5 | SER A 20PHE A 123THR A 127VAL A 126ILE A 10 | None | 1.48A | 2fj1A-2fu0A:undetectable | 2fj1A-2fu0A:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i00 | ACETYLTRANSFERASE,GNAT FAMILY (Enterococcusfaecalis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | PHE A 43VAL A 33LEU A 27ILE A 50SER A 52 | None | 1.42A | 2fj1A-2i00A:undetectable | 2fj1A-2i00A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ics | ADENINE DEAMINASE (Enterococcusfaecalis) |
PF01979(Amidohydro_1) | 5 | HIS A 211THR A 160VAL A 161GLN A 125ILE A 122 | ZN A 401 (-3.4A)ADE A1114 ( 4.3A)NoneADE A1114 (-3.3A)None | 1.15A | 2fj1A-2icsA:undetectable | 2fj1A-2icsA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iou | PERTACTINEXTRACELLULAR DOMAIN (Bordetellabronchiseptica) |
PF03212(Pertactin) | 5 | SER G 100THR G 115VAL G 116LEU G 91ILE G 54 | None | 1.47A | 2fj1A-2iouG:undetectable | 2fj1A-2iouG:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3e | T7I23.11 PROTEIN (Arabidopsisthaliana) |
PF04548(AIG1) | 5 | SER A 36PHE A 26THR A 38VAL A 39LEU A 155 | None | 1.43A | 2fj1A-2j3eA:undetectable | 2fj1A-2j3eA:25.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k1g | LIPOPROTEIN SPR (Escherichiacoli) |
PF00877(NLPC_P60) | 5 | SER A 69PHE A 76ARG A 157THR A 88GLN A 91 | None | 1.49A | 2fj1A-2k1gA:undetectable | 2fj1A-2k1gA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kdi | UBIQUITIN, VACUOLARPROTEINSORTING-ASSOCIATEDPROTEIN 27 FUSIONPROTEIN (Saccharomycescerevisiae) |
PF00240(ubiquitin)PF02809(UIM) | 5 | SER A 66THR A 64LEU A 24ILE A 12SER A 74 | None | 1.25A | 2fj1A-2kdiA:undetectable | 2fj1A-2kdiA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lpb | MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 15 (Saccharomycescerevisiae) |
no annotation | 5 | PRO A 191THR A 200VAL A 199LEU A 183ILE A 186 | None | 1.46A | 2fj1A-2lpbA:undetectable | 2fj1A-2lpbA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2myu | GLUTAREDOXINARSENATE REDUCTASE (Synechocystissp. PCC 6803) |
PF01451(LMWPc) | 5 | PRO A 104THR A 114VAL A 115GLN A 118LEU A 79 | None | 1.20A | 2fj1A-2myuA:undetectable | 2fj1A-2myuA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nv9 | A207R PROTEIN,ARGININEDECARBOXYLASE (ParameciumbursariaChlorella virus1) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | PHE A 66PRO A 253THR A 42LEU A 30ILE A 31 | None | 1.49A | 2fj1A-2nv9A:undetectable | 2fj1A-2nv9A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qde | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Aromatoleumaromaticum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 16THR A 379LEU A 373ILE A 345SER A 302 | None | 1.43A | 2fj1A-2qdeA:undetectable | 2fj1A-2qdeA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyv | XAA-HIS DIPEPTIDASE (Histophilussomni) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ARG A 68PRO A 135VAL A 71LEU A 411ILE A 408 | SO4 A 505 (-4.8A)NoneNoneNoneNone | 1.29A | 2fj1A-2qyvA:undetectable | 2fj1A-2qyvA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Staphylococcushaemolyticus) |
PF01409(tRNA-synt_2d) | 5 | PHE A 312PRO A 195THR A 115VAL A 116LEU A 124 | None | 1.41A | 2fj1A-2rhqA:undetectable | 2fj1A-2rhqA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn7 | GLUCOAMYLASE (Trichodermareesei) |
PF00686(CBM_20)PF00723(Glyco_hydro_15) | 5 | ARG A 226THR A 188VAL A 189GLN A 192LEU A 221 | None | 1.26A | 2fj1A-2vn7A:undetectable | 2fj1A-2vn7A:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdv | MYC-INDUCED NUCLEARANTIGEN (Homo sapiens) |
PF08007(Cupin_4) | 5 | SER A 257PRO A 140THR A 255VAL A 254ILE A 150 | NoneNoneOGA A 601 (-3.0A)NoneNone | 1.42A | 2fj1A-2xdvA:undetectable | 2fj1A-2xdvA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfn | ALPHA-GALACTOSIDASE-SUCROSE KINASE AGASK ([Ruminococcus]gnavus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | HIS A 226PRO A 230THR A 223LEU A 530ILE A 536 | None | 1.11A | 2fj1A-2yfnA:2.4 | 2fj1A-2yfnA:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1i | AMIDASE (Rhodococcus sp.N-771) |
PF01425(Amidase) | 5 | SER A 147ARG A 366THR A 376VAL A 377ILE A 223 | None | 1.25A | 2fj1A-3a1iA:undetectable | 2fj1A-3a1iA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2l | HALOALKANEDEHALOGENASE (Bradyrhizobiumjaponicum) |
PF00561(Abhydrolase_1) | 5 | HIS A 36SER A 41HIS A 81ARG A 208PRO A 209 | None | 1.36A | 2fj1A-3a2lA:undetectable | 2fj1A-3a2lA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bm1 | PROTEIN YDJA (Escherichiacoli) |
PF00881(Nitroreductase) | 5 | PHE A 146ARG A 132VAL A 115LEU A 160ILE A 90 | None | 1.30A | 2fj1A-3bm1A:undetectable | 2fj1A-3bm1A:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvc | GLYCOPROTEIN GP110 (Humangammaherpesvirus4) |
PF00606(Glycoprotein_B)PF17416(Glycoprot_B_PH1)PF17417(Glycoprot_B_PH2) | 5 | SER A 560THR A 535VAL A 536LEU A 572ILE A 578 | None | 1.36A | 2fj1A-3fvcA:undetectable | 2fj1A-3fvcA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gov | MASP-1 (Homo sapiens) |
PF00084(Sushi) | 5 | PRO A 360THR A 344VAL A 327LEU A 304SER A 356 | NoneGOL A 1 (-4.6A)NoneNoneNone | 1.46A | 2fj1A-3govA:undetectable | 2fj1A-3govA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn7 | UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE (Psychrobacterarcticus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | SER A 233HIS A 104PRO A 198LEU A 203ILE A 237 | None | 1.24A | 2fj1A-3hn7A:undetectable | 2fj1A-3hn7A:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9w | SENSOR PROTEIN TORS (Escherichiacoli) |
no annotation | 5 | SER A 292ARG A 43VAL A 298LEU A 85SER A 49 | None | 1.42A | 2fj1A-3i9wA:4.5 | 2fj1A-3i9wA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2j | PROTEIN VP1PROTEIN VP3PROTEIN VP2 (Enterovirus B;Enterovirus B;Enterovirus B) |
PF00073(Rhv)PF00073(Rhv)PF00073(Rhv) | 5 | HIS C 207PRO C 119VAL A 187ILE B 36SER C 198 | None | 1.46A | 2fj1A-3j2jC:undetectable | 2fj1A-3j2jC:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kal | HOMOGLUTATHIONESYNTHETASE (Glycine max) |
PF03199(GSH_synthase)PF03917(GSH_synth_ATP) | 5 | HIS A 135SER A 327VAL A 107ILE A 336SER A 117 | None | 1.44A | 2fj1A-3kalA:undetectable | 2fj1A-3kalA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kij | PROBABLE GLUTATHIONEPEROXIDASE 8 (Homo sapiens) |
PF00255(GSHPx) | 5 | SER A 99PHE A 101PRO A 135LEU A 62SER A 70 | None | 1.00A | 2fj1A-3kijA:undetectable | 2fj1A-3kijA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyj | PUTATIVE HISTIDINEPROTEIN KINASECHEY6 PROTEIN (Rhodobactersphaeroides;Rhodobactersphaeroides) |
PF01627(Hpt)PF00072(Response_reg) | 5 | ARG B 15VAL A 59LEU A 14ILE A 11SER B 20 | None | 1.09A | 2fj1A-3kyjB:undetectable | 2fj1A-3kyjB:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4e | UNCHARACTERIZEDPEPTIDASE LMO0363 (Listeriamonocytogenes) |
PF03575(Peptidase_S51) | 5 | PHE A 91THR A 85VAL A 84LEU A 150ILE A 124 | None | 1.20A | 2fj1A-3l4eA:undetectable | 2fj1A-3l4eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4e | UNCHARACTERIZEDPEPTIDASE LMO0363 (Listeriamonocytogenes) |
PF03575(Peptidase_S51) | 5 | SER A 36THR A 85VAL A 84LEU A 150ILE A 124 | None | 1.18A | 2fj1A-3l4eA:undetectable | 2fj1A-3l4eA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7m | 33 KDA CHAPERONIN (Escherichiacoli) |
PF01430(HSP33) | 5 | SER X 27THR X 25VAL X 24LEU X 156ILE X 158 | None | 1.44A | 2fj1A-3m7mX:undetectable | 2fj1A-3m7mX:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mj9 | JUNCTIONAL ADHESIONMOLECULE-LIKE (Mus musculus) |
PF07686(V-set) | 5 | SER A 217ARG A 183THR A 215LEU A 203ILE A 201 | None | 1.17A | 2fj1A-3mj9A:undetectable | 2fj1A-3mj9A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no4 | CREATININEAMIDOHYDROLASE (Nostocpunctiforme) |
PF02633(Creatininase) | 5 | ARG A 213THR A 176VAL A 173GLN A 177LEU A 220 | None | 1.42A | 2fj1A-3no4A:undetectable | 2fj1A-3no4A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oa3 | ALDOLASE (Coccidioidesimmitis) |
PF01791(DeoC) | 5 | SER A 103ARG A 147VAL A 108LEU A 122ILE A 95 | None | 1.48A | 2fj1A-3oa3A:undetectable | 2fj1A-3oa3A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsl | PUTATIVE EXPORTEDPROTEIN (Bordetellabronchiseptica) |
PF13379(NMT1_2) | 5 | HIS A 95SER A 148PRO A 116THR A 150VAL A 153 | CIT A 347 (-4.1A)CIT A 347 (-3.6A)NoneCIT A 347 (-3.2A)None | 1.43A | 2fj1A-3qslA:undetectable | 2fj1A-3qslA:24.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmj | 2-ISOPROPYLMALATESYNTHASE (Neisseriameningitidis) |
PF00682(HMGL-like) | 5 | HIS A 204ARG A 225LEU A 250ILE A 246SER A 216 | MN A 365 (-3.4A)NoneNoneNoneNone | 1.31A | 2fj1A-3rmjA:undetectable | 2fj1A-3rmjA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl1 | ARGINASE (Plasmodiumfalciparum) |
PF00491(Arginase) | 5 | HIS A 319SER A 363HIS A 193LEU A 47ILE A 189 | NoneNone MN A 413 (-3.3A)NoneNone | 1.44A | 2fj1A-3sl1A:undetectable | 2fj1A-3sl1A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upu | ATP-DEPENDENT DNAHELICASE DDA (Escherichiavirus T4) |
PF13604(AAA_30) | 5 | THR A 329VAL A 297LEU A 325ILE A 340SER A 385 | None | 1.35A | 2fj1A-3upuA:undetectable | 2fj1A-3upuA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upy | OXIDOREDUCTASE (Brucellaabortus) |
PF03447(NAD_binding_3) | 5 | SER A 273PRO A 252VAL A 271ILE A 264SER A 188 | None | 1.15A | 2fj1A-3upyA:undetectable | 2fj1A-3upyA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdg | URACIL-DNAGLYCOSYLASE (Staphylococcusaureus) |
PF03167(UDG) | 5 | PRO A 60THR A 117VAL A 118LEU A 23ILE A 132 | None | 1.40A | 2fj1A-3wdgA:undetectable | 2fj1A-3wdgA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqf | D-THREO-3-HYDROXYASPARTATE DEHYDRATASE (Delftia sp.HT23) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 5 | PHE A 339THR A 315VAL A 313LEU A 348ILE A 347 | None | 1.24A | 2fj1A-3wqfA:undetectable | 2fj1A-3wqfA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ziu | LEUCYL-TRNASYNTHETASE (Mycoplasmamobile) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 5 | PHE A 260ARG A 254GLN A 199LEU A 170ILE A 249 | NoneNoneNoneGOL A1642 (-4.9A)None | 1.46A | 2fj1A-3ziuA:undetectable | 2fj1A-3ziuA:14.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ac0 | TETRACYCLINEREPRESSOR PROTEINCLASS B FROMTRANSPOSON TN1 0 (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 6 | HIS A 64PHE A 86HIS A 100ARG A 104PRO A 105THR A 112 | MIY A1204 (-3.8A)MIY A1204 (-3.5A) MG A1205 ( 3.2A)MIY A1204 (-4.2A)MIY A1204 (-4.4A)MIY A1204 ( 4.7A) | 0.85A | 2fj1A-4ac0A:26.4 | 2fj1A-4ac0A:65.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ac0 | TETRACYCLINEREPRESSOR PROTEINCLASS B FROMTRANSPOSON TN1 0 (Escherichiacoli) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64PHE A 86HIS A 100PRO A 105THR A 112GLN A 116LEU A 131 | MIY A1204 (-3.8A)MIY A1204 (-3.5A) MG A1205 ( 3.2A)MIY A1204 (-4.4A)MIY A1204 ( 4.7A)MIY A1204 (-2.8A)MIY A1204 (-4.3A) | 0.61A | 2fj1A-4ac0A:26.4 | 2fj1A-4ac0A:65.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aqb | MANNAN-BINDINGLECTIN SERINEPROTEASE 1 (Homo sapiens) |
PF00084(Sushi)PF00431(CUB)PF14670(FXa_inhibition) | 5 | PRO A 360THR A 344VAL A 327LEU A 304SER A 356 | None | 1.46A | 2fj1A-4aqbA:undetectable | 2fj1A-4aqbA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgo | EFEM M75 PEPTIDASE (Pseudomonassyringae) |
PF09375(Peptidase_M75) | 5 | ARG A 86THR A 137GLN A 141LEU A 148ILE A 144 | None | 1.45A | 2fj1A-4bgoA:undetectable | 2fj1A-4bgoA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bl0 | CELL CYCLE ARRESTPROTEIN BUB3 (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | SER A 34THR A 36VAL A 37LEU A 70ILE A 72 | None | 1.31A | 2fj1A-4bl0A:undetectable | 2fj1A-4bl0A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4boc | DNA-DIRECTED RNAPOLYMERASE,MITOCHONDRIAL (Homo sapiens) |
PF00940(RNA_pol)PF14700(RPOL_N) | 5 | PHE A 277THR A 346VAL A 347LEU A 320ILE A 316 | None | 1.39A | 2fj1A-4bocA:2.1 | 2fj1A-4bocA:11.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d5c | TETRACYCLINEREPRESSOR PROTEINTETR (Proteusmirabilis) |
PF00440(TetR_N)PF02909(TetR_C) | 7 | HIS A 64PHE A 86HIS A 100ARG A 104PRO A 105THR A 112GLN A 116 | None | 0.82A | 2fj1A-4d5cA:26.3 | 2fj1A-4d5cA:59.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exq | UROPORPHYRINOGENDECARBOXYLASE (Burkholderiathailandensis) |
PF01208(URO-D) | 5 | PHE A 100THR A 172VAL A 173LEU A 188ILE A 187 | None | 0.87A | 2fj1A-4exqA:undetectable | 2fj1A-4exqA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fys | AMINOPEPTIDASE N (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | PHE A 898THR A 906VAL A 905LEU A 845ILE A 863 | None | 1.23A | 2fj1A-4fysA:undetectable | 2fj1A-4fysA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq2 | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | SER M 590PHE M 406ARG M 496THR M 411ILE M 418 | None | 1.40A | 2fj1A-4gq2M:1.4 | 2fj1A-4gq2M:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gx8 | DNA POLYMERASE IIISUBUNIT EPSILON,DNAPOLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF02811(PHP) | 5 | HIS A 103THR A 315VAL A 314LEU A 132ILE A 110 | None | 1.47A | 2fj1A-4gx8A:undetectable | 2fj1A-4gx8A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hzc | CYSE, SERINEACETYLTRANSFERASE (Brucellaabortus) |
PF00132(Hexapep)PF06426(SATase_N) | 5 | PRO A 111GLN A 96LEU A 51ILE A 19SER A 22 | None | 1.37A | 2fj1A-4hzcA:undetectable | 2fj1A-4hzcA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m2g | L-ARGININEBETA-HYDROXYLASE (Streptomyceslavendulae) |
PF02668(TauD) | 5 | HIS A 211ARG A 341THR A 122GLN A 123SER A 164 | None | 1.13A | 2fj1A-4m2gA:undetectable | 2fj1A-4m2gA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7s | BTRN (Bacilluscirculans) |
PF13186(SPASM) | 5 | PHE A 214THR A 179VAL A 178LEU A 48ILE A 205 | None | 1.34A | 2fj1A-4m7sA:undetectable | 2fj1A-4m7sA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oby | ARGININE--TRNALIGASE (Escherichiacoli) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | ARG A 245THR A 249VAL A 248LEU A 133ILE A 137 | None | 1.36A | 2fj1A-4obyA:undetectable | 2fj1A-4obyA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p4s | INTERFERON-INDUCEDGTP-BINDING PROTEINMX1 (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M) | 5 | SER A 230ARG A 208LEU A 179ILE A 76SER A 213 | None | 1.32A | 2fj1A-4p4sA:undetectable | 2fj1A-4p4sA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p4s | INTERFERON-INDUCEDGTP-BINDING PROTEINMX1 (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M) | 5 | SER B 230ARG B 208LEU B 179ILE B 76SER B 213 | None | 1.31A | 2fj1A-4p4sB:2.5 | 2fj1A-4p4sB:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgo | DNA-ENTRY NUCLEASE(COMPETENCE-SPECIFICNUCLEASE) (Streptococcusagalactiae) |
PF01223(Endonuclease_NS) | 5 | SER A 100THR A 211VAL A 210LEU A 154ILE A 150 | None | 1.27A | 2fj1A-4qgoA:undetectable | 2fj1A-4qgoA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qqs | GLYCOSIDE HYDROLASEFAMILY 43 (Halothermothrixorenii) |
PF04616(Glyco_hydro_43) | 5 | PRO A 18THR A 286VAL A 287LEU A 47ILE A 289 | None | 1.27A | 2fj1A-4qqsA:undetectable | 2fj1A-4qqsA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0s | PROTEIN TYROSINEPHOSPHATASE TPBA (Pseudomonasaeruginosa) |
PF03162(Y_phosphatase2) | 5 | ARG A 51THR A 77VAL A 75LEU A 69SER A 59 | None | 1.25A | 2fj1A-4r0sA:undetectable | 2fj1A-4r0sA:25.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xii | CHOLINESTERASE (Homo sapiens) |
PF00135(COesterase) | 5 | PHE A 405PRO A 303VAL A 233LEU A 168SER A 205 | None | 1.27A | 2fj1A-4xiiA:undetectable | 2fj1A-4xiiA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z61 | PHYTOSULFOKINERECEPTOR 1SOMATICEMBRYOGENESISRECEPTOR KINASE 2 (Daucus carota;Arabidopsisthaliana) |
PF00560(LRR_1)PF13855(LRR_8)PF00560(LRR_1)PF08263(LRRNT_2) | 5 | SER A 608PHE A 606THR C 67VAL C 66LEU C 39 | None | 1.40A | 2fj1A-4z61A:undetectable | 2fj1A-4z61A:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zht | BIFUNCTIONALUDP-N-ACETYLGLUCOSAMINE2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE (Homo sapiens) |
PF02350(Epimerase_2) | 5 | HIS A 167SER A 163HIS A 148THR A 161ILE A 178 | None | 1.45A | 2fj1A-4zhtA:undetectable | 2fj1A-4zhtA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zo6 | LIN1840 PROTEIN (Listeriainnocua) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | SER A 136THR A 134VAL A 133LEU A 300ILE A 268 | None | 1.25A | 2fj1A-4zo6A:undetectable | 2fj1A-4zo6A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c17 | MERB2 (Bacillusmegaterium) |
PF03243(MerB) | 5 | SER A 42THR A 40VAL A 39LEU A 26ILE A 25 | None | 1.34A | 2fj1A-5c17A:2.1 | 2fj1A-5c17A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d2n | C25 BETA (Homo sapiens) |
no annotation | 5 | SER F 109PHE F 107ARG F 36GLN F 6LEU F 77 | None | 1.31A | 2fj1A-5d2nF:undetectable | 2fj1A-5d2nF:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f4z | EPOXIDE HYDROLASE (Streptomycescarzinostaticus) |
PF06441(EHN) | 5 | SER A 181HIS A 97PRO A 135VAL A 153ILE A 307 | None | 1.48A | 2fj1A-5f4zA:undetectable | 2fj1A-5f4zA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fr7 | AMYR (Erwiniaamylovora) |
PF10722(YbjN) | 5 | SER A 130VAL A 103LEU A 77ILE A 80SER A 83 | None | 1.46A | 2fj1A-5fr7A:undetectable | 2fj1A-5fr7A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 5 | SER A 238GLN A 241LEU A 248ILE A 244SER A 229 | None | 1.34A | 2fj1A-5gw7A:undetectable | 2fj1A-5gw7A:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h07 | POLYUBIQUITIN-C (Homo sapiens) |
PF00240(ubiquitin) | 5 | SER A 157THR A 155LEU A 115ILE A 103SER A 165 | None | 1.45A | 2fj1A-5h07A:undetectable | 2fj1A-5h07A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5icg | (S)-NORCOCLAURINE6-O-METHYLTRANSFERASE (Thalictrumflavum) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 5 | HIS A 256VAL A 341GLN A 342LEU A 172ILE A 173 | None | 1.35A | 2fj1A-5icgA:undetectable | 2fj1A-5icgA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ier | OHP9 (syntheticconstruct) |
PF02136(NTF2) | 5 | THR A 118VAL A 111LEU A 6ILE A 85SER A 79 | SO4 A 203 ( 4.2A)NoneNoneNoneNone | 1.42A | 2fj1A-5ierA:undetectable | 2fj1A-5ierA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mbg | BETA SUBUNIT OFPHOTOACTIVATEDADENYLYL CYCLASE (Beggiatoa sp.PS) |
PF00211(Guanylate_cyc) | 5 | SER A 249PHE A 154THR A 293ILE A 216SER A 219 | NoneNoneIOD A 403 ( 4.9A)NoneNone | 1.28A | 2fj1A-5mbgA:undetectable | 2fj1A-5mbgA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mbh | BETA SUBUNIT OFPHOTOACTIVATEDADENYLYL CYCLASE (Beggiatoa sp.PS) |
PF00211(Guanylate_cyc)PF04940(BLUF) | 5 | SER A 249PHE A 154THR A 293ILE A 216SER A 219 | None | 1.26A | 2fj1A-5mbhA:undetectable | 2fj1A-5mbhA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjv | CAPSID SUBUNIT VP3CAPSID SUBUNIT VP0 (Parechovirus A;Parechovirus A) |
no annotationPF00073(Rhv) | 5 | SER B 85PHE C 201PRO C 250THR B 87ILE B 231 | None | 1.38A | 2fj1A-5mjvB:undetectable | 2fj1A-5mjvB:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mmd | METALLO-BETA-LACTAMASE 1 (Acinetobacterbaumannii) |
PF00753(Lactamase_B) | 5 | HIS E 116PRO E 192VAL E 202LEU E 283ILE E 223 | ZN E 403 (-3.3A)NoneNoneNoneNone | 1.20A | 2fj1A-5mmdE:undetectable | 2fj1A-5mmdE:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 7 | HIS A 64PHE A 86HIS A 100ARG A 104PRO A 105THR A 112GLN A 116 | TDC A 301 (-3.8A)TDC A 301 (-3.3A) MG A 302 ( 3.2A)TDC A 301 (-4.0A)TDC A 301 (-4.5A)NoneTDC A 301 (-2.8A) | 0.66A | 2fj1A-5mruA:23.8 | 2fj1A-5mruA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 8 | HIS A 64SER A 67PHE A 86HIS A 100PRO A 105THR A 112GLN A 116SER A 138 | TDC A 301 (-3.8A)TDC A 301 (-3.3A)TDC A 301 (-3.3A) MG A 302 ( 3.2A)TDC A 301 (-4.5A)NoneTDC A 301 (-2.8A)TDC A 301 ( 3.7A) | 0.83A | 2fj1A-5mruA:23.8 | 2fj1A-5mruA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odo | ISOMERASE (Rhodococcuserythropolis) |
no annotation | 5 | HIS A 401HIS A 399ARG A 76ILE A 233SER A 225 | NoneNoneFMT A 607 (-3.6A)NoneNone | 1.16A | 2fj1A-5odoA:undetectable | 2fj1A-5odoA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tjj | TRANSCRIPTIONALREGULATOR, ICLRFAMILY (Alicyclobacillusacidocaldarius) |
PF01614(IclR)PF09339(HTH_IclR) | 5 | SER A 56ARG A 20LEU A 35ILE A 31SER A 26 | None | 1.25A | 2fj1A-5tjjA:2.1 | 2fj1A-5tjjA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3c | CTP SYNTHASE (Escherichiacoli) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | PHE A 532PRO A 350VAL A 308LEU A 327ILE A 325 | None | 1.36A | 2fj1A-5u3cA:undetectable | 2fj1A-5u3cA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u47 | PENICILLIN BINDINGPROTEIN 2X (Streptococcusthermophilus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 5 | SER A 440THR A 463VAL A 462GLN A 466LEU A 423 | None | 1.43A | 2fj1A-5u47A:undetectable | 2fj1A-5u47A:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7n | DIAMINOPIMELATEDECARBOXYLASE (Corynebacteriumglutamicum) |
no annotation | 5 | PRO A 16THR A 401VAL A 310LEU A 37ILE A 312 | None | 1.45A | 2fj1A-5x7nA:undetectable | 2fj1A-5x7nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfm | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | PHE A 494ARG A 513LEU A 308ILE A 307SER A 462 | None | 1.33A | 2fj1A-5xfmA:undetectable | 2fj1A-5xfmA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC1 (Saccharomycescerevisiae) |
no annotation | 5 | HIS A 941THR A 680VAL A 677LEU A 613ILE A 614 | None | 1.45A | 2fj1A-6f42A:3.5 | 2fj1A-6f42A:undetectable |