SIMILAR PATTERNS OF AMINO ACIDS FOR 2FEU_A_CAMA1420_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ag9 | FLAVODOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1) | 4 | THR A 4LEU A 26VAL A 161VAL A 117 | None | 0.95A | 2feuA-1ag9A:0.0 | 2feuA-1ag9A:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lfp | HYPOTHETICAL PROTEINAQ_1575 (Aquifexaeolicus) |
PF01709(Transcrip_reg) | 4 | PHE A 117LEU A 222VAL A 234VAL A 130 | None | 0.84A | 2feuA-1lfpA:undetectable | 2feuA-1lfpA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5w | HYPOTHETICAL UPF0244PROTEIN YJJX (Escherichiacoli) |
PF01931(NTPase_I-T) | 4 | THR A 87LEU A 123VAL A 126VAL A 145 | None | 1.05A | 2feuA-1u5wA:undetectable | 2feuA-1u5wA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) |
PF00579(tRNA-synt_1b) | 5 | PHE A 236THR A 263LEU A 303VAL A 307VAL A 244 | None | 1.31A | 2feuA-1vbmA:0.0 | 2feuA-1vbmA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1 (Thermusthermophilus) |
PF02347(GDC-P) | 4 | PHE A 415LEU A 393VAL A 389VAL A 363 | None | 1.02A | 2feuA-1wytA:0.0 | 2feuA-1wytA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xgy | K42-41L FAB HEAVYCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 27THR H 94LEU H 4VAL H 71 | None | 1.08A | 2feuA-1xgyH:undetectable | 2feuA-1xgyH:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 4 | THR A 506LEU A 521VAL A 802VAL A 537 | None | 0.83A | 2feuA-1ygpA:0.0 | 2feuA-1ygpA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys9 | PROTEIN SPY1043 (Streptococcuspyogenes) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 4 | PHE A 27LEU A 246VAL A 225VAL A 202 | None | 1.08A | 2feuA-1ys9A:0.0 | 2feuA-1ys9A:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yyr | TRICHODIENE SYNTHASE (Fusariumsporotrichioides) |
PF06330(TRI5) | 4 | TYR A 93LEU A 150VAL A 138VAL A 81 | SAZ A 709 (-4.9A)NoneNoneNone | 0.99A | 2feuA-1yyrA:0.0 | 2feuA-1yyrA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajh | LEUCYL-TRNASYNTHETASE (Escherichiacoli) |
PF13603(tRNA-synt_1_2) | 4 | PHE A 253LEU A 259VAL A 245VAL A 408 | None | 1.03A | 2feuA-2ajhA:undetectable | 2feuA-2ajhA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2awa | DNA POLYMERASE III,BETA CHAIN (Streptococcuspneumoniae) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | PHE A 11LEU A 77VAL A 34VAL A 38 | None | 0.92A | 2feuA-2awaA:undetectable | 2feuA-2awaA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b7h | HEMOGLOBIN ALPHACHAIN (Cerdocyon thous) |
PF00042(Globin) | 4 | PHE A 43THR A 32VAL A 62VAL A 93 | HEM A 200 (-3.5A)NoneHEM A 200 ( 3.8A)HEM A 200 (-4.3A) | 0.95A | 2feuA-2b7hA:undetectable | 2feuA-2b7hA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9s | TOPOISOMERASE I-LIKEPROTEIN (Leishmaniadonovani) |
PF01028(Topoisom_I)PF02919(Topoisom_I_N) | 4 | THR A 375LEU A 339VAL A 345VAL A 303 | None | 1.00A | 2feuA-2b9sA:undetectable | 2feuA-2b9sA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cf5 | CINNAMYL ALCOHOLDEHYDROGENASE (Arabidopsisthaliana) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | TYR A 27THR A 10LEU A 29VAL A 71 | None | 1.01A | 2feuA-2cf5A:undetectable | 2feuA-2cf5A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dwz | 26S PROTEASEREGULATORY SUBUNIT6B (Rattusnorvegicus) |
no annotation | 4 | THR B 349LEU B 354VAL B 358VAL B 364 | None | 1.02A | 2feuA-2dwzB:undetectable | 2feuA-2dwzB:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iue | INTEGRIN BETA-2-LIKEPROTEIN (Mus musculus) |
PF00362(Integrin_beta) | 4 | TYR A 179THR A 112LEU A 110VAL A 89 | None | 1.02A | 2feuA-2iueA:undetectable | 2feuA-2iueA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k8d | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRB (Methanothermobacterthermautotrophicus) |
PF01641(SelR) | 4 | PHE A 90LEU A 123VAL A 114VAL A 94 | None | 1.00A | 2feuA-2k8dA:undetectable | 2feuA-2k8dA:17.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 4 | PHE A 87TYR A 96LEU A 244VAL A 396 | CAM A 502 (-4.6A)CAM A 502 (-4.5A)HEM A 501 (-4.5A)None | 0.66A | 2feuA-2m56A:70.0 | 2feuA-2m56A:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 6 | PHE A 87TYR A 96THR A 101LEU A 244VAL A 247VAL A 295 | CAM A 502 (-4.6A)CAM A 502 (-4.5A)HEM A 501 (-2.9A)HEM A 501 (-4.5A)NoneHEM A 501 (-4.6A) | 0.28A | 2feuA-2m56A:70.0 | 2feuA-2m56A:99.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m83 | PROTEIN PHOSPHATASE1 REGULATORY SUBUNIT3A (Oryctolaguscuniculus) |
PF03370(CBM_21) | 4 | THR A 135LEU A 231VAL A 207VAL A 161 | None | 1.02A | 2feuA-2m83A:undetectable | 2feuA-2m83A:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og2 | PUTATIVE SIGNALRECOGNITION PARTICLERECEPTOR (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | THR A 217LEU A 198VAL A 238VAL A 272 | None | 1.07A | 2feuA-2og2A:undetectable | 2feuA-2og2A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oz4 | FAB FRAGMENT, HEAVYCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 27THR H 98LEU H 4VAL H 72 | None | 1.00A | 2feuA-2oz4H:undetectable | 2feuA-2oz4H:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqv | MUTT/NUDIX FAMILYPROTEIN (Streptococcuspneumoniae) |
PF00293(NUDIX) | 4 | THR A 40LEU A 128VAL A 131VAL A 76 | None | 1.02A | 2feuA-2pqvA:undetectable | 2feuA-2pqvA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r8r | SENSOR PROTEIN (Pseudomonassyringae groupgenomosp. 3) |
PF02702(KdpD) | 4 | THR A 204LEU A 8VAL A 121VAL A 133 | None | 1.00A | 2feuA-2r8rA:undetectable | 2feuA-2r8rA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uun | C-PHYCOCYANIN (Leptolyngbyasp.) |
PF00502(Phycobilisome) | 4 | PHE B 164THR B 94VAL B 142VAL B 51 | NoneNoneBLA B 255 (-4.5A)None | 1.08A | 2feuA-2uunB:undetectable | 2feuA-2uunB:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsm | HYDROGENASEEXPRESSION/FORMATIONPROTEIN (HYPB) (Archaeoglobusfulgidus) |
PF02492(cobW) | 4 | THR A 50LEU A 113VAL A 33VAL A 160 | None | 0.95A | 2feuA-2wsmA:undetectable | 2feuA-2wsmA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wy4 | SINGLE DOMAINHAEMOGLOBIN (Campylobacterjejuni) |
PF00042(Globin) | 4 | PHE A 42TYR A 28LEU A 56VAL A 89 | HEM A 150 ( 3.5A)CYN A 151 (-4.7A)CYN A 151 (-4.1A)HEM A 150 (-3.8A) | 1.07A | 2feuA-2wy4A:undetectable | 2feuA-2wy4A:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zhp | BLEOMYCIN RESISTANCEPROTEIN (Streptoalloteichushindustanus) |
no annotation | 4 | PHE A 29LEU A 108VAL A 116VAL A 68 | None | 1.05A | 2feuA-2zhpA:undetectable | 2feuA-2zhpA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5q | PUTATIVE SULFATASEYIDJ (Bacteroidesthetaiotaomicron) |
PF00884(Sulfatase)PF16347(DUF4976) | 4 | THR A 276LEU A 267VAL A 263VAL A 113 | None | 0.92A | 2feuA-3b5qA:undetectable | 2feuA-3b5qA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 4 | TYR A 227LEU A 279VAL A 278VAL A 223 | None | 0.90A | 2feuA-3b9tA:undetectable | 2feuA-3b9tA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bx8 | ENGINEERED HUMANLIPOCALIN 2 (Homo sapiens) |
PF00061(Lipocalin) | 4 | PHE A 83TYR A 56THR A 54VAL A 121 | NoneNone1PE A 179 ( 4.7A)None | 0.98A | 2feuA-3bx8A:undetectable | 2feuA-3bx8A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqq | PUTATIVE TRNASYNTHASE (Salmonellaenterica) |
PF07005(DUF1537)PF17042(DUF1357_C) | 4 | PHE A 11THR A 368LEU A 398VAL A 389 | None | 0.96A | 2feuA-3dqqA:undetectable | 2feuA-3dqqA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8m | SERINEHYDROXYMETHYLTRANSFERASE (Escherichiacoli) |
PF00464(SHMT) | 4 | PHE A 302LEU A 32VAL A 344VAL A 389 | None | 1.02A | 2feuA-3g8mA:undetectable | 2feuA-3g8mA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gqp | HEMOGLOBIN SUBUNITALPHA (Felis catus) |
PF00042(Globin) | 4 | PHE A 43THR A 32VAL A 62VAL A 93 | HEM A 143 (-3.7A)NoneHEM A 143 ( 4.1A)HEM A 143 (-4.1A) | 1.00A | 2feuA-3gqpA:undetectable | 2feuA-3gqpA:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl2 | PUTATIVEISOCHORISMATASE (Streptomycesavermitilis) |
PF00857(Isochorismatase) | 4 | PHE A 154LEU A 173VAL A 196VAL A 168 | None | 1.07A | 2feuA-3kl2A:undetectable | 2feuA-3kl2A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1l | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 4 | PHE A 431TYR A 430THR A 177VAL A 189 | None | 1.00A | 2feuA-3m1lA:undetectable | 2feuA-3m1lA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9v | FAD-DEPENDENTOXIDOREDUCTASE (Actinomadurakijaniata) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | THR A 151LEU A 163VAL A 199VAL A 170 | None | 0.96A | 2feuA-3m9vA:undetectable | 2feuA-3m9vA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mc2 | INHIBITOR OFCARBONIC ANHYDRASE (Mus musculus) |
PF00405(Transferrin) | 4 | THR A 375LEU A 398VAL A 399VAL A 600 | None | 0.97A | 2feuA-3mc2A:undetectable | 2feuA-3mc2A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvl | MYOSIN VIIA ISOFORM1 (Mus musculus) |
PF00784(MyTH4) | 4 | PHE A1532LEU A1511VAL A1498VAL A1489 | NoneNoneNoneGOL A 1 ( 4.7A) | 1.02A | 2feuA-3pvlA:undetectable | 2feuA-3pvlA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rim | TRANSKETOLASE (Mycobacteriumtuberculosis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | THR A 561LEU A 573VAL A 600VAL A 555 | None | 0.83A | 2feuA-3rimA:undetectable | 2feuA-3rimA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3skv | SSFX3 (Streptomycessp. SF2575) |
PF13472(Lipase_GDSL_2) | 4 | THR A 71LEU A 152VAL A 150VAL A 103 | None | 0.98A | 2feuA-3skvA:undetectable | 2feuA-3skvA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tos | CALS11 (Micromonosporaechinospora) |
PF05711(TylF) | 4 | THR A 181LEU A 175VAL A 171VAL A 161 | None | 0.97A | 2feuA-3tosA:undetectable | 2feuA-3tosA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr9 | DIHYDROPTEROATESYNTHASE (Coxiellaburnetii) |
PF00809(Pterin_bind) | 4 | PHE A 202LEU A 172VAL A 175VAL A 231 | None | 0.91A | 2feuA-3tr9A:undetectable | 2feuA-3tr9A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9p | NEUTROPHILGELATINASE-ASSOCIATED LIPOCALIN (Mus musculus) |
PF00061(Lipocalin) | 4 | PHE C 79TYR C 50THR C 48VAL C 117 | None | 1.03A | 2feuA-3u9pC:undetectable | 2feuA-3u9pC:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubc | HEMOGLOBIN-LIKEFLAVOPROTEIN (Methylacidiphiluminfernorum) |
PF00042(Globin) | 4 | PHE A 43TYR A 29LEU A 54VAL A 87 | HEM A 201 (-3.8A)NoneOXY A 202 ( 4.3A)HEM A 201 (-4.1A) | 1.03A | 2feuA-3ubcA:undetectable | 2feuA-3ubcA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umf | ADENYLATE KINASE (Schistosomamansoni) |
PF00406(ADK) | 4 | PHE A 13TYR A 96LEU A 74VAL A 110 | None | 0.86A | 2feuA-3umfA:undetectable | 2feuA-3umfA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgq | CYCLIN-DEPENDENTKINASE-LIKE 5 (Homo sapiens) |
PF00069(Pkinase) | 4 | PHE A 297LEU A 277VAL A 197VAL A 112 | None | 1.06A | 2feuA-4bgqA:undetectable | 2feuA-4bgqA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4boc | DNA-DIRECTED RNAPOLYMERASE,MITOCHONDRIAL (Homo sapiens) |
PF00940(RNA_pol)PF14700(RPOL_N) | 4 | PHE A1229TYR A1153THR A1135VAL A1222 | None | 1.05A | 2feuA-4bocA:undetectable | 2feuA-4bocA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7p | RALF (Legionellapneumophila) |
PF01369(Sec7) | 4 | PHE A 114THR A 139LEU A 135VAL A 126 | None | 1.00A | 2feuA-4c7pA:undetectable | 2feuA-4c7pA:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 4 | TYR A 98THR A 103LEU A 252VAL A 303 | NoneGOL A1419 (-3.8A)HEM A1418 (-4.0A)GOL A1419 (-3.9A) | 0.50A | 2feuA-4c9mA:58.6 | 2feuA-4c9mA:44.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 4 | TYR A 98THR A 103LEU A 252VAL A 404 | NoneGOL A1419 (-3.8A)HEM A1418 (-4.0A)GOL A1419 (-3.5A) | 0.88A | 2feuA-4c9mA:58.6 | 2feuA-4c9mA:44.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czw | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Neurosporacrassa) |
PF00929(RNase_T)PF13423(UCH_1) | 4 | THR A 593LEU A 508VAL A 511VAL A 721 | None | 0.79A | 2feuA-4czwA:undetectable | 2feuA-4czwA:21.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 4 | PHE A 87THR A 101LEU A 250VAL A 301 | NoneHEM A 501 ( 4.8A)HEM A 501 (-4.3A)PEG A 502 ( 4.5A) | 0.98A | 2feuA-4dxyA:51.9 | 2feuA-4dxyA:46.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ehc | PE-PGRS FAMILYPROTEIN (Mycobacteriumtuberculosis) |
no annotation | 4 | PHE A 153LEU A 35VAL A 21VAL A 79 | None | 0.96A | 2feuA-4ehcA:undetectable | 2feuA-4ehcA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eut | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | PHE A 112LEU A 281VAL A 280VAL A 119 | None | 1.05A | 2feuA-4eutA:undetectable | 2feuA-4eutA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euu | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | PHE A 112LEU A 281VAL A 280VAL A 119 | None | 1.04A | 2feuA-4euuA:undetectable | 2feuA-4euuA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0q | RESTRICTIONENDONUCLEASE (Mycobacteriumsp. JLS) |
PF04471(Mrr_cat) | 4 | THR A 437LEU A 433VAL A 418VAL A 386 | None | 1.00A | 2feuA-4f0qA:undetectable | 2feuA-4f0qA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1p | CYS-GLYMETALLODIPEPTIDASEDUG1 (Saccharomycescerevisiae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | PHE A 429LEU A 181VAL A 83VAL A 164 | None | 1.07A | 2feuA-4g1pA:undetectable | 2feuA-4g1pA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jdl | ABSCISIC ACIDRECEPTOR PYL5 (Arabidopsisthaliana) |
PF10604(Polyketide_cyc2) | 4 | THR A 152LEU A 154VAL A 73VAL A 85 | None | 0.98A | 2feuA-4jdlA:undetectable | 2feuA-4jdlA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxf | TREHALOSE SYNTHASE (Mycobacteriumtuberculosis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 4 | TYR A 164THR A 142VAL A 216VAL A 23 | None | 1.04A | 2feuA-4lxfA:undetectable | 2feuA-4lxfA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m7g | TRYPSIN-LIKEPROTEASE (Saccharopolysporaerythraea) |
PF00089(Trypsin) | 4 | THR A 44LEU A 92VAL A 37VAL A 192 | None | 0.98A | 2feuA-4m7gA:undetectable | 2feuA-4m7gA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0r | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesvulgatus) |
PF13204(DUF4038)PF16586(DUF5060) | 4 | TYR A 314LEU A 342VAL A 350VAL A 355 | None | 1.06A | 2feuA-4n0rA:undetectable | 2feuA-4n0rA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o0l | NADPH-DEPENDENT3-QUINUCLIDINONEREDUCTASE (Rhodotorulamucilaginosa) |
PF13561(adh_short_C2) | 4 | PHE A 161TYR A 110THR A 34VAL A 188 | None | 0.85A | 2feuA-4o0lA:undetectable | 2feuA-4o0lA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqf | PROTEIN RECA (Mycobacteriumtuberculosis) |
PF00154(RecA) | 4 | THR A 43LEU A 57VAL A 222VAL A 226 | None | 1.08A | 2feuA-4oqfA:undetectable | 2feuA-4oqfA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9o | ISOPRENYLTRANSFERASE (Streptococcuspneumoniae) |
PF01255(Prenyltransf) | 4 | PHE A 143THR A 56LEU A 102VAL A 99 | 2ZW A 301 (-3.5A)2ZW A 301 ( 4.9A)2ZW A 301 (-4.5A)2ZW A 301 (-4.6A) | 0.88A | 2feuA-4q9oA:undetectable | 2feuA-4q9oA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qww | ACETYLCHOLINESTERASE (Bungarusfasciatus) |
PF00135(COesterase) | 4 | THR A 317LEU A 210VAL A 206VAL A 194 | None | 1.05A | 2feuA-4qwwA:undetectable | 2feuA-4qwwA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhh | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF03512(Glyco_hydro_52) | 4 | PHE A 353LEU A 295VAL A 102VAL A 14 | None | 1.04A | 2feuA-4rhhA:undetectable | 2feuA-4rhhA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4std | SCYTALONEDEHYDRATASE (Magnaporthegrisea) |
PF02982(Scytalone_dh) | 4 | PHE A 53TYR A 50VAL A 75VAL A 108 | NoneBFS A 173 (-4.3A)BFS A 173 (-4.5A)BFS A 173 ( 4.4A) | 1.02A | 2feuA-4stdA:undetectable | 2feuA-4stdA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txd | CSC2 (Thermofilumpendens) |
no annotation | 4 | THR A 85LEU A 249VAL A 43VAL A 39 | None | 1.01A | 2feuA-4txdA:undetectable | 2feuA-4txdA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txd | CSC2 (Thermofilumpendens) |
no annotation | 4 | THR A 85LEU A 249VAL A 264VAL A 39 | None | 0.93A | 2feuA-4txdA:undetectable | 2feuA-4txdA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wy8 | ESTERASE (Rhizomucormiehei) |
PF07859(Abhydrolase_3) | 4 | PHE A 128TYR A 225LEU A 169VAL A 172 | None | 1.07A | 2feuA-4wy8A:undetectable | 2feuA-4wy8A:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | THR A 124LEU A 167VAL A 165VAL A 308 | None | 1.04A | 2feuA-4x0oA:undetectable | 2feuA-4x0oA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y96 | TRIOSEPHOSPHATEISOMERASE (Gemmataobscuriglobus) |
PF00121(TIM) | 4 | PHE A 163TYR A 202VAL A 151VAL A 117 | None | 0.96A | 2feuA-4y96A:undetectable | 2feuA-4y96A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypv | EST8 (Parvibaculum) |
PF07859(Abhydrolase_3) | 4 | PHE A 125TYR A 220LEU A 164VAL A 167 | None | 1.07A | 2feuA-4ypvA:undetectable | 2feuA-4ypvA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8t | AVRRXO1-ORF1 (Xanthomonasoryzae) |
no annotation | 4 | THR A 184LEU A 142VAL A 243VAL A 194 | None | 0.85A | 2feuA-4z8tA:undetectable | 2feuA-4z8tA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ah4 | DNA POLYMERASE IIISUBUNIT BETA (Mycolicibacteriumsmegmatis) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | THR A 88LEU A 84VAL A 43VAL A 67 | None | 0.96A | 2feuA-5ah4A:undetectable | 2feuA-5ah4A:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cay | ENVELOPEGLYCOPROTEIN GP120CORE FROM ST STRAINOF HIV-2 (Humanimmunodeficiencyvirus 2) |
PF00516(GP120) | 4 | PHE G 482LEU G 301VAL G 357VAL G 412 | None | 0.93A | 2feuA-5cayG:undetectable | 2feuA-5cayG:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cj3 | ZBM BINDING PROTEIN (Streptomycesflavoviridis) |
no annotation | 4 | PHE A 29LEU A 108VAL A 116VAL A 68 | None | 1.06A | 2feuA-5cj3A:undetectable | 2feuA-5cj3A:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5efr | BAMA-BAMD FUSIONPROTEIN (Rhodothermusmarinus) |
PF07244(POTRA)PF13525(YfiO) | 4 | PHE A 419THR A 413LEU A 459VAL A 448 | None | 1.05A | 2feuA-5efrA:undetectable | 2feuA-5efrA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f5v | PRP38 (Chaetomiumthermophilum) |
PF03371(PRP38) | 4 | TYR A 105LEU A 119VAL A 65VAL A 56 | None | 1.02A | 2feuA-5f5vA:undetectable | 2feuA-5f5vA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7s | GLYCOSIDE HYDROLASEFAMILY 31 (Trueperellapyogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 4 | PHE A 655TYR A 656LEU A 277VAL A 276 | None | 1.07A | 2feuA-5f7sA:undetectable | 2feuA-5f7sA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITALPHA TYPE 2,PUTATIVE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | THR B 161LEU B 135VAL B 75VAL B 29 | None | 1.04A | 2feuA-5fmgB:undetectable | 2feuA-5fmgB:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gte | LACHRYMATORY-FACTORSYNTHASE (Allium cepa) |
PF10604(Polyketide_cyc2) | 4 | PHE A 104TYR A 114LEU A 152VAL A 73 | None | 0.89A | 2feuA-5gteA:undetectable | 2feuA-5gteA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k53 | ALDEHYDEDEFORMYLATINGOXYGENASE (Oscillatoriasp.) |
PF11266(Ald_deCOase) | 4 | TYR A 17LEU A 74VAL A 76VAL A 28 | NoneNoneNoneSTE A 502 ( 4.8A) | 1.01A | 2feuA-5k53A:undetectable | 2feuA-5k53A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kh0 | SMALL GTP-BINDINGPROTEIN (Thermosiphomelanesiensis) |
PF01926(MMR_HSR1) | 4 | THR A 320LEU A 324VAL A 292VAL A 379 | None | 0.98A | 2feuA-5kh0A:undetectable | 2feuA-5kh0A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3r | CELL DIVISIONPROTEIN FTSYHOMOLOG,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | THR B 255LEU B 236VAL B 276VAL B 310 | None | 0.99A | 2feuA-5l3rB:undetectable | 2feuA-5l3rB:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lad | PUTATIVE GTP-BINDINGPROTEIN (Thermotogamaritima) |
PF01926(MMR_HSR1) | 4 | TYR A 139THR A 96LEU A 94VAL A 108 | None | 0.97A | 2feuA-5ladA:undetectable | 2feuA-5ladA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldd | MON1CCZ1 (Chaetomiumthermophilum;Chaetomiumthermophilum) |
PF03164(Mon1)PF08217(DUF1712) | 4 | PHE B 114LEU A 226VAL A 287VAL A 274 | None | 0.95A | 2feuA-5lddB:undetectable | 2feuA-5lddB:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mz9 | - (-) |
no annotation | 4 | TYR A 322THR A 343VAL A 547VAL A 543 | None | 1.04A | 2feuA-5mz9A:undetectable | 2feuA-5mz9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy7 | NEURONAL PASDOMAIN-CONTAININGPROTEIN 3 (Mus musculus) |
PF00010(HLH)PF00989(PAS)PF08447(PAS_3) | 4 | PHE B 176LEU B 187VAL B 183VAL B 318 | None | 1.05A | 2feuA-5sy7B:undetectable | 2feuA-5sy7B:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmb | SERINEHYDROXYMETHYLTRANSFERASE (Acinetobacterbaumannii) |
PF00464(SHMT) | 4 | PHE A 301LEU A 31VAL A 343VAL A 388 | None | 1.04A | 2feuA-5vmbA:undetectable | 2feuA-5vmbA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtn | REPLICATIONINITIATION ANDMEMBRANE ATTACHMENTPROTEIN (Geobacillusstearothermophilus) |
no annotation | 4 | PHE A 211LEU A 266VAL A 229VAL A 220 | None | 1.07A | 2feuA-5wtnA:undetectable | 2feuA-5wtnA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2g | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Campylobacterjejuni) |
no annotation | 4 | PHE A 7TYR A 459THR A 651LEU A 435 | None | 0.96A | 2feuA-5x2gA:undetectable | 2feuA-5x2gA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 4 | PHE A 277THR A 322LEU A 394VAL A 297 | None | 1.02A | 2feuA-5xwbA:undetectable | 2feuA-5xwbA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yew | MITOFUSIN-1,MITOFUSIN-1 FUSION PROTEIN (Homo sapiens) |
no annotation | 4 | PHE B 320LEU B 176VAL B 78VAL B 205 | None | 1.06A | 2feuA-5yewB:undetectable | 2feuA-5yewB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eu6 | AMMONIUM TRANSPORTER (CandidatusKueneniastuttgartiensis) |
no annotation | 5 | PHE A 34TYR A 30THR A 213LEU A 274VAL A 325 | None | 1.28A | 2feuA-6eu6A:undetectable | 2feuA-6eu6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ffl | MALTOSE/MALTODEXTRINTRANSPORT PERMEASEHOMOLOGUE (Bdellovibriobacteriovorus) |
no annotation | 4 | PHE A 90TYR A 89THR A 295LEU A 291 | None | 1.01A | 2feuA-6fflA:undetectable | 2feuA-6fflA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fml | RUVB-LIKE HELICASE (Chaetomiumthermophilum) |
no annotation | 4 | PHE D 349LEU D 303VAL D 300VAL D 323 | None | 1.08A | 2feuA-6fmlD:undetectable | 2feuA-6fmlD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbg | OUTER MEMBRANEPROTEIN (Helicobacterpylori) |
no annotation | 4 | PHE A 277THR A 272LEU A 241VAL A 101 | None | 1.03A | 2feuA-6gbgA:undetectable | 2feuA-6gbgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gh2 | LAMINARIBIOSEPHOSPHORYLASE (Paenibacillussp. YM1) |
no annotation | 4 | THR A 805LEU A 761VAL A 760VAL A 676 | None | 0.96A | 2feuA-6gh2A:undetectable | 2feuA-6gh2A:undetectable |