SIMILAR PATTERNS OF AMINO ACIDS FOR 2FEU_A_CAMA1420_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli)
PF00258
(Flavodoxin_1)
4 THR A   4
LEU A  26
VAL A 161
VAL A 117
None
0.95A 2feuA-1ag9A:
0.0
2feuA-1ag9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575


(Aquifex
aeolicus)
PF01709
(Transcrip_reg)
4 PHE A 117
LEU A 222
VAL A 234
VAL A 130
None
0.84A 2feuA-1lfpA:
undetectable
2feuA-1lfpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5w HYPOTHETICAL UPF0244
PROTEIN YJJX


(Escherichia
coli)
PF01931
(NTPase_I-T)
4 THR A  87
LEU A 123
VAL A 126
VAL A 145
None
1.05A 2feuA-1u5wA:
undetectable
2feuA-1u5wA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00579
(tRNA-synt_1b)
5 PHE A 236
THR A 263
LEU A 303
VAL A 307
VAL A 244
None
1.31A 2feuA-1vbmA:
0.0
2feuA-1vbmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1


(Thermus
thermophilus)
PF02347
(GDC-P)
4 PHE A 415
LEU A 393
VAL A 389
VAL A 363
None
1.02A 2feuA-1wytA:
0.0
2feuA-1wytA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  27
THR H  94
LEU H   4
VAL H  71
None
1.08A 2feuA-1xgyH:
undetectable
2feuA-1xgyH:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
4 THR A 506
LEU A 521
VAL A 802
VAL A 537
None
0.83A 2feuA-1ygpA:
0.0
2feuA-1ygpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys9 PROTEIN SPY1043

(Streptococcus
pyogenes)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
4 PHE A  27
LEU A 246
VAL A 225
VAL A 202
None
1.08A 2feuA-1ys9A:
0.0
2feuA-1ys9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides)
PF06330
(TRI5)
4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
SAZ  A 709 (-4.9A)
None
None
None
0.99A 2feuA-1yyrA:
0.0
2feuA-1yyrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF13603
(tRNA-synt_1_2)
4 PHE A 253
LEU A 259
VAL A 245
VAL A 408
None
1.03A 2feuA-2ajhA:
undetectable
2feuA-2ajhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN


(Streptococcus
pneumoniae)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 PHE A  11
LEU A  77
VAL A  34
VAL A  38
None
0.92A 2feuA-2awaA:
undetectable
2feuA-2awaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN


(Cerdocyon thous)
PF00042
(Globin)
4 PHE A  43
THR A  32
VAL A  62
VAL A  93
HEM  A 200 (-3.5A)
None
HEM  A 200 ( 3.8A)
HEM  A 200 (-4.3A)
0.95A 2feuA-2b7hA:
undetectable
2feuA-2b7hA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN


(Leishmania
donovani)
PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
4 THR A 375
LEU A 339
VAL A 345
VAL A 303
None
1.00A 2feuA-2b9sA:
undetectable
2feuA-2b9sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE


(Arabidopsis
thaliana)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 TYR A  27
THR A  10
LEU A  29
VAL A  71
None
1.01A 2feuA-2cf5A:
undetectable
2feuA-2cf5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B


(Rattus
norvegicus)
no annotation 4 THR B 349
LEU B 354
VAL B 358
VAL B 364
None
1.02A 2feuA-2dwzB:
undetectable
2feuA-2dwzB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN


(Mus musculus)
PF00362
(Integrin_beta)
4 TYR A 179
THR A 112
LEU A 110
VAL A  89
None
1.02A 2feuA-2iueA:
undetectable
2feuA-2iueA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB


(Methanothermobacter
thermautotrophicus)
PF01641
(SelR)
4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
None
1.00A 2feuA-2k8dA:
undetectable
2feuA-2k8dA:
17.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
0.66A 2feuA-2m56A:
70.0
2feuA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
6 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 247
VAL A 295
CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
0.28A 2feuA-2m56A:
70.0
2feuA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m83 PROTEIN PHOSPHATASE
1 REGULATORY SUBUNIT
3A


(Oryctolagus
cuniculus)
PF03370
(CBM_21)
4 THR A 135
LEU A 231
VAL A 207
VAL A 161
None
1.02A 2feuA-2m83A:
undetectable
2feuA-2m83A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 THR A 217
LEU A 198
VAL A 238
VAL A 272
None
1.07A 2feuA-2og2A:
undetectable
2feuA-2og2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 FAB FRAGMENT, HEAVY
CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  27
THR H  98
LEU H   4
VAL H  72
None
1.00A 2feuA-2oz4H:
undetectable
2feuA-2oz4H:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqv MUTT/NUDIX FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF00293
(NUDIX)
4 THR A  40
LEU A 128
VAL A 131
VAL A  76
None
1.02A 2feuA-2pqvA:
undetectable
2feuA-2pqvA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3)
PF02702
(KdpD)
4 THR A 204
LEU A   8
VAL A 121
VAL A 133
None
1.00A 2feuA-2r8rA:
undetectable
2feuA-2r8rA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.)
PF00502
(Phycobilisome)
4 PHE B 164
THR B  94
VAL B 142
VAL B  51
None
None
BLA  B 255 (-4.5A)
None
1.08A 2feuA-2uunB:
undetectable
2feuA-2uunB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)


(Archaeoglobus
fulgidus)
PF02492
(cobW)
4 THR A  50
LEU A 113
VAL A  33
VAL A 160
None
0.95A 2feuA-2wsmA:
undetectable
2feuA-2wsmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN


(Campylobacter
jejuni)
PF00042
(Globin)
4 PHE A  42
TYR A  28
LEU A  56
VAL A  89
HEM  A 150 ( 3.5A)
CYN  A 151 (-4.7A)
CYN  A 151 (-4.1A)
HEM  A 150 (-3.8A)
1.07A 2feuA-2wy4A:
undetectable
2feuA-2wy4A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhp BLEOMYCIN RESISTANCE
PROTEIN


(Streptoalloteichus
hindustanus)
no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
None
1.05A 2feuA-2zhpA:
undetectable
2feuA-2zhpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ


(Bacteroides
thetaiotaomicron)
PF00884
(Sulfatase)
PF16347
(DUF4976)
4 THR A 276
LEU A 267
VAL A 263
VAL A 113
None
0.92A 2feuA-3b5qA:
undetectable
2feuA-3b5qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Methylobacillus
flagellatus)
PF03069
(FmdA_AmdA)
4 TYR A 227
LEU A 279
VAL A 278
VAL A 223
None
0.90A 2feuA-3b9tA:
undetectable
2feuA-3b9tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bx8 ENGINEERED HUMAN
LIPOCALIN 2


(Homo sapiens)
PF00061
(Lipocalin)
4 PHE A  83
TYR A  56
THR A  54
VAL A 121
None
None
1PE  A 179 ( 4.7A)
None
0.98A 2feuA-3bx8A:
undetectable
2feuA-3bx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE


(Salmonella
enterica)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
4 PHE A  11
THR A 368
LEU A 398
VAL A 389
None
0.96A 2feuA-3dqqA:
undetectable
2feuA-3dqqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF00464
(SHMT)
4 PHE A 302
LEU A  32
VAL A 344
VAL A 389
None
1.02A 2feuA-3g8mA:
undetectable
2feuA-3g8mA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
ALPHA


(Felis catus)
PF00042
(Globin)
4 PHE A  43
THR A  32
VAL A  62
VAL A  93
HEM  A 143 (-3.7A)
None
HEM  A 143 ( 4.1A)
HEM  A 143 (-4.1A)
1.00A 2feuA-3gqpA:
undetectable
2feuA-3gqpA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl2 PUTATIVE
ISOCHORISMATASE


(Streptomyces
avermitilis)
PF00857
(Isochorismatase)
4 PHE A 154
LEU A 173
VAL A 196
VAL A 168
None
1.07A 2feuA-3kl2A:
undetectable
2feuA-3kl2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
4 PHE A 431
TYR A 430
THR A 177
VAL A 189
None
1.00A 2feuA-3m1lA:
undetectable
2feuA-3m1lA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE


(Actinomadura
kijaniata)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 THR A 151
LEU A 163
VAL A 199
VAL A 170
None
0.96A 2feuA-3m9vA:
undetectable
2feuA-3m9vA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE


(Mus musculus)
PF00405
(Transferrin)
4 THR A 375
LEU A 398
VAL A 399
VAL A 600
None
0.97A 2feuA-3mc2A:
undetectable
2feuA-3mc2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1


(Mus musculus)
PF00784
(MyTH4)
4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
None
None
None
GOL  A   1 ( 4.7A)
1.02A 2feuA-3pvlA:
undetectable
2feuA-3pvlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 THR A 561
LEU A 573
VAL A 600
VAL A 555
None
0.83A 2feuA-3rimA:
undetectable
2feuA-3rimA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575)
PF13472
(Lipase_GDSL_2)
4 THR A  71
LEU A 152
VAL A 150
VAL A 103
None
0.98A 2feuA-3skvA:
undetectable
2feuA-3skvA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora)
PF05711
(TylF)
4 THR A 181
LEU A 175
VAL A 171
VAL A 161
None
0.97A 2feuA-3tosA:
undetectable
2feuA-3tosA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE


(Coxiella
burnetii)
PF00809
(Pterin_bind)
4 PHE A 202
LEU A 172
VAL A 175
VAL A 231
None
0.91A 2feuA-3tr9A:
undetectable
2feuA-3tr9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9p NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN


(Mus musculus)
PF00061
(Lipocalin)
4 PHE C  79
TYR C  50
THR C  48
VAL C 117
None
1.03A 2feuA-3u9pC:
undetectable
2feuA-3u9pC:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN


(Methylacidiphilum
infernorum)
PF00042
(Globin)
4 PHE A  43
TYR A  29
LEU A  54
VAL A  87
HEM  A 201 (-3.8A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
1.03A 2feuA-3ubcA:
undetectable
2feuA-3ubcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni)
PF00406
(ADK)
4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
None
0.86A 2feuA-3umfA:
undetectable
2feuA-3umfA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5


(Homo sapiens)
PF00069
(Pkinase)
4 PHE A 297
LEU A 277
VAL A 197
VAL A 112
None
1.06A 2feuA-4bgqA:
undetectable
2feuA-4bgqA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL


(Homo sapiens)
PF00940
(RNA_pol)
PF14700
(RPOL_N)
4 PHE A1229
TYR A1153
THR A1135
VAL A1222
None
1.05A 2feuA-4bocA:
undetectable
2feuA-4bocA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila)
PF01369
(Sec7)
4 PHE A 114
THR A 139
LEU A 135
VAL A 126
None
1.00A 2feuA-4c7pA:
undetectable
2feuA-4c7pA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
4 TYR A  98
THR A 103
LEU A 252
VAL A 303
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
0.50A 2feuA-4c9mA:
58.6
2feuA-4c9mA:
44.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
4 TYR A  98
THR A 103
LEU A 252
VAL A 404
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 (-3.5A)
0.88A 2feuA-4c9mA:
58.6
2feuA-4c9mA:
44.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Neurospora
crassa)
PF00929
(RNase_T)
PF13423
(UCH_1)
4 THR A 593
LEU A 508
VAL A 511
VAL A 721
None
0.79A 2feuA-4czwA:
undetectable
2feuA-4czwA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
4 PHE A  87
THR A 101
LEU A 250
VAL A 301
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 ( 4.5A)
0.98A 2feuA-4dxyA:
51.9
2feuA-4dxyA:
46.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN


(Mycobacterium
tuberculosis)
no annotation 4 PHE A 153
LEU A  35
VAL A  21
VAL A  79
None
0.96A 2feuA-4ehcA:
undetectable
2feuA-4ehcA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Homo sapiens)
PF00069
(Pkinase)
4 PHE A 112
LEU A 281
VAL A 280
VAL A 119
None
1.05A 2feuA-4eutA:
undetectable
2feuA-4eutA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Homo sapiens)
PF00069
(Pkinase)
4 PHE A 112
LEU A 281
VAL A 280
VAL A 119
None
1.04A 2feuA-4euuA:
undetectable
2feuA-4euuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE


(Mycobacterium
sp. JLS)
PF04471
(Mrr_cat)
4 THR A 437
LEU A 433
VAL A 418
VAL A 386
None
1.00A 2feuA-4f0qA:
undetectable
2feuA-4f0qA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1


(Saccharomyces
cerevisiae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 PHE A 429
LEU A 181
VAL A  83
VAL A 164
None
1.07A 2feuA-4g1pA:
undetectable
2feuA-4g1pA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdl ABSCISIC ACID
RECEPTOR PYL5


(Arabidopsis
thaliana)
PF10604
(Polyketide_cyc2)
4 THR A 152
LEU A 154
VAL A  73
VAL A  85
None
0.98A 2feuA-4jdlA:
undetectable
2feuA-4jdlA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 TYR A 164
THR A 142
VAL A 216
VAL A  23
None
1.04A 2feuA-4lxfA:
undetectable
2feuA-4lxfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE


(Saccharopolyspora
erythraea)
PF00089
(Trypsin)
4 THR A  44
LEU A  92
VAL A  37
VAL A 192
None
0.98A 2feuA-4m7gA:
undetectable
2feuA-4m7gA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE


(Bacteroides
vulgatus)
PF13204
(DUF4038)
PF16586
(DUF5060)
4 TYR A 314
LEU A 342
VAL A 350
VAL A 355
None
1.06A 2feuA-4n0rA:
undetectable
2feuA-4n0rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE


(Rhodotorula
mucilaginosa)
PF13561
(adh_short_C2)
4 PHE A 161
TYR A 110
THR A  34
VAL A 188
None
0.85A 2feuA-4o0lA:
undetectable
2feuA-4o0lA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis)
PF00154
(RecA)
4 THR A  43
LEU A  57
VAL A 222
VAL A 226
None
1.08A 2feuA-4oqfA:
undetectable
2feuA-4oqfA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9o ISOPRENYL
TRANSFERASE


(Streptococcus
pneumoniae)
PF01255
(Prenyltransf)
4 PHE A 143
THR A  56
LEU A 102
VAL A  99
2ZW  A 301 (-3.5A)
2ZW  A 301 ( 4.9A)
2ZW  A 301 (-4.5A)
2ZW  A 301 (-4.6A)
0.88A 2feuA-4q9oA:
undetectable
2feuA-4q9oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus)
PF00135
(COesterase)
4 THR A 317
LEU A 210
VAL A 206
VAL A 194
None
1.05A 2feuA-4qwwA:
undetectable
2feuA-4qwwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF03512
(Glyco_hydro_52)
4 PHE A 353
LEU A 295
VAL A 102
VAL A  14
None
1.04A 2feuA-4rhhA:
undetectable
2feuA-4rhhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE


(Magnaporthe
grisea)
PF02982
(Scytalone_dh)
4 PHE A  53
TYR A  50
VAL A  75
VAL A 108
None
BFS  A 173 (-4.3A)
BFS  A 173 (-4.5A)
BFS  A 173 ( 4.4A)
1.02A 2feuA-4stdA:
undetectable
2feuA-4stdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens)
no annotation 4 THR A  85
LEU A 249
VAL A  43
VAL A  39
None
1.01A 2feuA-4txdA:
undetectable
2feuA-4txdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens)
no annotation 4 THR A  85
LEU A 249
VAL A 264
VAL A  39
None
0.93A 2feuA-4txdA:
undetectable
2feuA-4txdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei)
PF07859
(Abhydrolase_3)
4 PHE A 128
TYR A 225
LEU A 169
VAL A 172
None
1.07A 2feuA-4wy8A:
undetectable
2feuA-4wy8A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 THR A 124
LEU A 167
VAL A 165
VAL A 308
None
1.04A 2feuA-4x0oA:
undetectable
2feuA-4x0oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE


(Gemmata
obscuriglobus)
PF00121
(TIM)
4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
None
0.96A 2feuA-4y96A:
undetectable
2feuA-4y96A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum)
PF07859
(Abhydrolase_3)
4 PHE A 125
TYR A 220
LEU A 164
VAL A 167
None
1.07A 2feuA-4ypvA:
undetectable
2feuA-4ypvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae)
no annotation 4 THR A 184
LEU A 142
VAL A 243
VAL A 194
None
0.85A 2feuA-4z8tA:
undetectable
2feuA-4z8tA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA


(Mycolicibacterium
smegmatis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
4 THR A  88
LEU A  84
VAL A  43
VAL A  67
None
0.96A 2feuA-5ah4A:
undetectable
2feuA-5ah4A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2


(Human
immunodeficiency
virus 2)
PF00516
(GP120)
4 PHE G 482
LEU G 301
VAL G 357
VAL G 412
None
0.93A 2feuA-5cayG:
undetectable
2feuA-5cayG:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj3 ZBM BINDING PROTEIN

(Streptomyces
flavoviridis)
no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
None
1.06A 2feuA-5cj3A:
undetectable
2feuA-5cj3A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efr BAMA-BAMD FUSION
PROTEIN


(Rhodothermus
marinus)
PF07244
(POTRA)
PF13525
(YfiO)
4 PHE A 419
THR A 413
LEU A 459
VAL A 448
None
1.05A 2feuA-5efrA:
undetectable
2feuA-5efrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum)
PF03371
(PRP38)
4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
None
1.02A 2feuA-5f5vA:
undetectable
2feuA-5f5vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31


(Trueperella
pyogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
4 PHE A 655
TYR A 656
LEU A 277
VAL A 276
None
1.07A 2feuA-5f7sA:
undetectable
2feuA-5f7sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE 2,
PUTATIVE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
4 THR B 161
LEU B 135
VAL B  75
VAL B  29
None
1.04A 2feuA-5fmgB:
undetectable
2feuA-5fmgB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE


(Allium cepa)
PF10604
(Polyketide_cyc2)
4 PHE A 104
TYR A 114
LEU A 152
VAL A  73
None
0.89A 2feuA-5gteA:
undetectable
2feuA-5gteA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE


(Oscillatoria
sp.)
PF11266
(Ald_deCOase)
4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
None
None
None
STE  A 502 ( 4.8A)
1.01A 2feuA-5k53A:
undetectable
2feuA-5k53A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN


(Thermosipho
melanesiensis)
PF01926
(MMR_HSR1)
4 THR A 320
LEU A 324
VAL A 292
VAL A 379
None
0.98A 2feuA-5kh0A:
undetectable
2feuA-5kh0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 THR B 255
LEU B 236
VAL B 276
VAL B 310
None
0.99A 2feuA-5l3rB:
undetectable
2feuA-5l3rB:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN


(Thermotoga
maritima)
PF01926
(MMR_HSR1)
4 TYR A 139
THR A  96
LEU A  94
VAL A 108
None
0.97A 2feuA-5ladA:
undetectable
2feuA-5ladA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1
CCZ1


(Chaetomium
thermophilum;
Chaetomium
thermophilum)
PF03164
(Mon1)
PF08217
(DUF1712)
4 PHE B 114
LEU A 226
VAL A 287
VAL A 274
None
0.95A 2feuA-5lddB:
undetectable
2feuA-5lddB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-)
no annotation 4 TYR A 322
THR A 343
VAL A 547
VAL A 543
None
1.04A 2feuA-5mz9A:
undetectable
2feuA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3


(Mus musculus)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
None
1.05A 2feuA-5sy7B:
undetectable
2feuA-5sy7B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE


(Acinetobacter
baumannii)
PF00464
(SHMT)
4 PHE A 301
LEU A  31
VAL A 343
VAL A 388
None
1.04A 2feuA-5vmbA:
undetectable
2feuA-5vmbA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN


(Geobacillus
stearothermophilus)
no annotation 4 PHE A 211
LEU A 266
VAL A 229
VAL A 220
None
1.07A 2feuA-5wtnA:
undetectable
2feuA-5wtnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Campylobacter
jejuni)
no annotation 4 PHE A   7
TYR A 459
THR A 651
LEU A 435
None
0.96A 2feuA-5x2gA:
undetectable
2feuA-5x2gA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Colwellia
psychrerythraea)
PF00275
(EPSP_synthase)
4 PHE A 277
THR A 322
LEU A 394
VAL A 297
None
1.02A 2feuA-5xwbA:
undetectable
2feuA-5xwbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN


(Homo sapiens)
no annotation 4 PHE B 320
LEU B 176
VAL B  78
VAL B 205
None
1.06A 2feuA-5yewB:
undetectable
2feuA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis)
no annotation 5 PHE A  34
TYR A  30
THR A 213
LEU A 274
VAL A 325
None
1.28A 2feuA-6eu6A:
undetectable
2feuA-6eu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE


(Bdellovibrio
bacteriovorus)
no annotation 4 PHE A  90
TYR A  89
THR A 295
LEU A 291
None
1.01A 2feuA-6fflA:
undetectable
2feuA-6fflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum)
no annotation 4 PHE D 349
LEU D 303
VAL D 300
VAL D 323
None
1.08A 2feuA-6fmlD:
undetectable
2feuA-6fmlD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN


(Helicobacter
pylori)
no annotation 4 PHE A 277
THR A 272
LEU A 241
VAL A 101
None
1.03A 2feuA-6gbgA:
undetectable
2feuA-6gbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE


(Paenibacillus
sp. YM1)
no annotation 4 THR A 805
LEU A 761
VAL A 760
VAL A 676
None
0.96A 2feuA-6gh2A:
undetectable
2feuA-6gh2A:
undetectable