SIMILAR PATTERNS OF AMINO ACIDS FOR 2FCN_B_DVAB35

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 GLN A 120
GLU A 122
ILE A 144
PRO A 145
 None
 1.11A 2fcnA-1c0nA:
0.0
2fcnB-1c0nA:
0.0		 2fcnA-1c0nA:
11.22
2fcnB-1c0nA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		4 ARG A 255
GLN A 192
GLU A 193
ILE A 196
 None
 1.05A 2fcnA-1c9wA:
undetectable
2fcnB-1c9wA:
undetectable		 2fcnA-1c9wA:
17.81
2fcnB-1c9wA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 GLN A 256
GLU A 107
ILE A 109
PRO A 255
 None
 1.03A 2fcnA-1fcdA:
0.0
2fcnB-1fcdA:
0.0		 2fcnA-1fcdA:
11.47
2fcnB-1fcdA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 LEU A 565
GLU A 514
ILE A 460
PRO A 459
 None
 0.90A 2fcnA-1fokA:
undetectable
2fcnB-1fokA:
undetectable		 2fcnA-1fokA:
9.14
2fcnB-1fokA:
9.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gjz UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.68A 2fcnA-1gjzA:
4.7
2fcnB-1gjzA:
5.2		 2fcnA-1gjzA:
92.45
2fcnB-1gjzA:
92.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		4 GLN A 155
GLU A 152
ILE A 151
PRO A 171
 None
 1.10A 2fcnA-1ihpA:
0.0
2fcnB-1ihpA:
0.0		 2fcnA-1ihpA:
10.21
2fcnB-1ihpA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 LEU A 151
GLN A  25
GLU A  27
ILE A  24
 None
 1.11A 2fcnA-1ka0A:
0.0
2fcnB-1ka0A:
0.0		 2fcnA-1ka0A:
14.75
2fcnB-1ka0A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu2 LECTIN

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		4 LEU A 214
GLU A 220
ILE A 219
PRO A  42
 A2G  A 254 (-4.1A)
None
None
None
 0.90A 2fcnA-1lu2A:
undetectable
2fcnB-1lu2A:
0.0		 2fcnA-1lu2A:
14.68
2fcnB-1lu2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 4 LEU A  31
GLU A  39
ILE A  35
PRO A  34
 None
 0.94A 2fcnA-1p7nA:
undetectable
2fcnB-1p7nA:
undetectable		 2fcnA-1p7nA:
19.53
2fcnB-1p7nA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 LEU A  87
GLN A  94
GLU A  37
ILE A  93
 None
 1.07A 2fcnA-1qpaA:
0.0
2fcnB-1qpaA:
undetectable		 2fcnA-1qpaA:
13.19
2fcnB-1qpaA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ARG A 450
GLU A 407
ILE A 403
PRO A 400
 None
 0.83A 2fcnA-1qvrA:
undetectable
2fcnB-1qvrA:
undetectable		 2fcnA-1qvrA:
6.99
2fcnB-1qvrA:
6.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sif UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.53A 2fcnA-1sifA:
15.1
2fcnB-1sifA:
14.8		 2fcnA-1sifA:
90.79
2fcnB-1sifA:
90.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		4 ARG A  40
GLU A   7
ILE A   6
PRO A   5
 None
 1.07A 2fcnA-1sr8A:
undetectable
2fcnB-1sr8A:
undetectable		 2fcnA-1sr8A:
13.56
2fcnB-1sr8A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		4 LEU A  40
GLU A  57
ILE A  62
PRO A  61
 None
 1.07A 2fcnA-1wwsA:
undetectable
2fcnB-1wwsA:
undetectable		 2fcnA-1wwsA:
19.44
2fcnB-1wwsA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yx5 UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.78A 2fcnA-1yx5B:
15.7
2fcnB-1yx5B:
15.5		 2fcnA-1yx5B:
97.37
2fcnB-1yx5B:
97.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD

(Thermus
thermophilus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ARG F 256
LEU F 308
GLN F 312
GLU F 313
 None
 1.09A 2fcnA-2a6eF:
undetectable
2fcnB-2a6eF:
undetectable		 2fcnA-2a6eF:
13.54
2fcnB-2a6eF:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		4 LEU A  67
GLN A  71
GLU A  73
ILE A  72
 None
None
GOL  A 602 (-3.4A)
None
 0.91A 2fcnA-2fccA:
undetectable
2fcnB-2fccA:
undetectable		 2fcnA-2fccA:
19.85
2fcnB-2fccA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 265
GLN A 260
ILE A 261
PRO A 262
 None
 1.01A 2fcnA-2i80A:
undetectable
2fcnB-2i80A:
undetectable		 2fcnA-2i80A:
14.10
2fcnB-2i80A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijy THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Vibrio cholerae) 		PF01323
(DSBA) 		4 ARG A  92
GLN A 108
GLU A 105
ILE A 109
 None
 0.99A 2fcnA-2ijyA:
undetectable
2fcnB-2ijyA:
undetectable		 2fcnA-2ijyA:
20.00
2fcnB-2ijyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ARG A 255
GLN A 192
GLU A 193
ILE A 196
 None
 1.01A 2fcnA-2is7A:
undetectable
2fcnB-2is7A:
undetectable		 2fcnA-2is7A:
12.50
2fcnB-2is7A:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2mbb POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B 231
GLU B 234
ILE B 236
PRO B 237
 None
 0.73A 2fcnA-2mbbB:
14.3
2fcnB-2mbbB:
14.2		 2fcnA-2mbbB:
94.87
2fcnB-2mbbB:
94.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		4 ARG A 640
LEU A 808
GLN A 653
ILE A 652
 None
 1.06A 2fcnA-2qmaA:
undetectable
2fcnB-2qmaA:
undetectable		 2fcnA-2qmaA:
10.48
2fcnB-2qmaA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 ARG A1857
LEU A1868
ILE A1871
PRO A1870
 None
 0.96A 2fcnA-2vz9A:
undetectable
2fcnB-2vz9A:
undetectable		 2fcnA-2vz9A:
2.56
2fcnB-2vz9A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz0 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF05773
(RWD) 		4 LEU A  19
GLN A  15
GLU A  13
ILE A  14
 None
 1.02A 2fcnA-2yz0A:
undetectable
2fcnB-2yz0A:
undetectable		 2fcnA-2yz0A:
17.39
2fcnB-2yz0A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 GLN A 263
GLU A 266
ILE A 268
PRO A 269
 None
 0.44A 2fcnA-3ai5A:
16.0
2fcnB-3ai5A:
16.3		 2fcnA-3ai5A:
27.55
2fcnB-3ai5A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi) 		PF01633
(Choline_kinase) 		4 ARG A 348
LEU A 321
GLU A 254
ILE A 253
 CHT  A1001 ( 4.8A)
None
CA  A 371 ( 3.4A)
GOL  A1003 (-4.3A)
 0.97A 2fcnA-3c5iA:
undetectable
2fcnB-3c5iA:
undetectable		 2fcnA-3c5iA:
11.78
2fcnB-3c5iA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 4 LEU A  54
GLN A  71
GLU A  73
ILE A  72
 None
 1.05A 2fcnA-3cawA:
undetectable
2fcnB-3cawA:
undetectable		 2fcnA-3cawA:
12.19
2fcnB-3cawA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjd TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Jannaschia sp.
CCS1) 		PF00440
(TetR_N)
PF13305
(WHG) 		4 LEU A  19
GLN A  23
GLU A  25
ILE A  24
 None
 1.07A 2fcnA-3cjdA:
undetectable
2fcnB-3cjdA:
undetectable		 2fcnA-3cjdA:
20.20
2fcnB-3cjdA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  12
GLN A 300
GLU A 302
ILE A 303
 None
 1.01A 2fcnA-3d6bA:
undetectable
2fcnB-3d6bA:
undetectable		 2fcnA-3d6bA:
14.04
2fcnB-3d6bA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		4 LEU A  96
GLU A  99
ILE A 104
PRO A 106
 None
 1.07A 2fcnA-3ednA:
undetectable
2fcnB-3ednA:
undetectable		 2fcnA-3ednA:
14.96
2fcnB-3ednA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 ARG A  84
GLU A  39
ILE A  41
PRO A  42
 None
 0.98A 2fcnA-3hveA:
undetectable
2fcnB-3hveA:
undetectable		 2fcnA-3hveA:
15.19
2fcnB-3hveA:
15.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9o UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.38A 2fcnA-3k9oB:
16.1
2fcnB-3k9oB:
15.5		 2fcnA-3k9oB:
80.43
2fcnB-3k9oB:
80.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3l0w MONOUBIQUITINATED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02747
(PCNA_C) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.03A 2fcnA-3l0wB:
13.4
2fcnB-3l0wB:
13.2		 2fcnA-3l0wB:
93.42
2fcnB-3l0wB:
93.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		4 ARG B 338
LEU B 328
GLU B 363
ILE B 331
 None
 0.79A 2fcnA-3l2oB:
undetectable
2fcnB-3l2oB:
undetectable		 2fcnA-3l2oB:
11.80
2fcnB-3l2oB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l82 F-BOX ONLY PROTEIN 4

(Homo sapiens) 		no annotation 4 ARG B 338
LEU B 328
GLU B 363
ILE B 331
 None
 0.88A 2fcnA-3l82B:
undetectable
2fcnB-3l82B:
undetectable		 2fcnA-3l82B:
15.21
2fcnB-3l82B:
15.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3k UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.59A 2fcnA-3n3kB:
16.2
2fcnB-3n3kB:
16.0		 2fcnA-3n3kB:
78.48
2fcnB-3n3kB:
78.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 ARG A 256
GLN A 193
GLU A 194
ILE A 197
 None
 1.07A 2fcnA-3o3rA:
undetectable
2fcnB-3o3rA:
undetectable		 2fcnA-3o3rA:
13.62
2fcnB-3o3rA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3x GP41-5

(synthetic
construct) 		no annotation 4 LEU A 101
GLN A  99
GLU A  96
ILE A  95
 None
 1.08A 2fcnA-3o3xA:
undetectable
2fcnB-3o3xA:
undetectable		 2fcnA-3o3xA:
18.52
2fcnB-3o3xA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o60 LIN0861 PROTEIN

(Listeria
innocua) 		no annotation 4 LEU A  28
GLN A  71
GLU A  69
ILE A  72
 None
 0.94A 2fcnA-3o60A:
undetectable
2fcnB-3o60A:
undetectable		 2fcnA-3o60A:
23.78
2fcnB-3o60A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3paf 50S RIBOSOMAL
PROTEIN L7AE

(Methanocaldococcus
jannaschii) 		PF01248
(Ribosomal_L7Ae) 		4 LEU A  18
GLN A  14
GLU A  12
ILE A  13
 None
 1.11A 2fcnA-3pafA:
undetectable
2fcnB-3pafA:
undetectable		 2fcnA-3pafA:
24.14
2fcnB-3pafA:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN

(Bacillus
amyloliquefaciens;
Homo sapiens) 		PF00240
(ubiquitin)
PF00545
(Ribonuclease) 		4 GLN A 135
GLU A 138
ILE A 140
PRO A 141
 None
 0.78A 2fcnA-3q3fA:
14.0
2fcnB-3q3fA:
14.4		 2fcnA-3q3fA:
44.91
2fcnB-3q3fA:
44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Vibrio cholerae) 		PF02540
(NAD_synthase) 		4 LEU A  40
GLN A  58
ILE A  98
PRO A 100
 None
CA  A 277 (-4.2A)
None
None
 0.95A 2fcnA-3q4gA:
undetectable
2fcnB-3q4gA:
undetectable		 2fcnA-3q4gA:
16.22
2fcnB-3q4gA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 LEU A 231
GLN A 292
GLU A 295
ILE A 228
 None
 1.05A 2fcnA-3rpkA:
undetectable
2fcnB-3rpkA:
undetectable		 2fcnA-3rpkA:
8.67
2fcnB-3rpkA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 LEU A 435
GLN A 785
GLU A 788
ILE A 784
 None
 1.07A 2fcnA-3tbkA:
undetectable
2fcnB-3tbkA:
undetectable		 2fcnA-3tbkA:
12.44
2fcnB-3tbkA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 GLN A 723
GLU A 705
ILE A 722
PRO A 721
 None
 1.03A 2fcnA-3ua4A:
undetectable
2fcnB-3ua4A:
undetectable		 2fcnA-3ua4A:
8.20
2fcnB-3ua4A:
8.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 GLN A 131
GLU A 134
ILE A 136
PRO A 137
 None
 0.48A 2fcnA-3vdzA:
16.1
2fcnB-3vdzA:
16.1		 2fcnA-3vdzA:
94.94
2fcnB-3vdzA:
94.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7l TROPOMYOSIN 1 ALPHA

(Oryctolagus
cuniculus) 		PF00261
(Tropomyosin) 		4 LEU B 148
GLN B 144
GLU B 142
ILE B 143
 None
 1.11A 2fcnA-4a7lB:
undetectable
2fcnB-4a7lB:
undetectable		 2fcnA-4a7lB:
20.74
2fcnB-4a7lB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 LEU A 226
GLU A 128
ILE A 169
PRO A 170
 None
None
None
NAP  A 900 ( 4.4A)
 1.03A 2fcnA-4b8wA:
undetectable
2fcnB-4b8wA:
undetectable		 2fcnA-4b8wA:
15.64
2fcnB-4b8wA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 ARG A  68
LEU A  20
GLU A  25
ILE A  26
 None
 1.10A 2fcnA-4gqbA:
undetectable
2fcnB-4gqbA:
undetectable		 2fcnA-4gqbA:
8.09
2fcnB-4gqbA:
8.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gsw UBIQUITIN

(Entamoeba
histolytica) 		PF00240
(ubiquitin) 		4 GLN A  34
GLU A  37
ILE A  39
PRO A  40
 None
 0.70A 2fcnA-4gswA:
15.5
2fcnB-4gswA:
16.2		 2fcnA-4gswA:
83.54
2fcnB-4gswA:
83.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.38A 2fcnA-4ii2B:
13.9
2fcnB-4ii2B:
13.6		 2fcnA-4ii2B:
77.11
2fcnB-4ii2B:
77.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.38A 2fcnA-4ii3B:
14.7
2fcnB-4ii3B:
14.2		 2fcnA-4ii3B:
86.75
2fcnB-4ii3B:
86.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 234
GLN A 209
ILE A 211
PRO A 212
 None
 1.04A 2fcnA-4jq9A:
undetectable
2fcnB-4jq9A:
undetectable		 2fcnA-4jq9A:
10.41
2fcnB-4jq9A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsm COLLAGEN-LIKE
PROTEIN SCLB

(Streptococcus
pyogenes) 		no annotation 4 ARG A  28
GLN A  59
GLU A  56
ILE A  60
 None
 1.02A 2fcnA-4nsmA:
undetectable
2fcnB-4nsmA:
undetectable		 2fcnA-4nsmA:
24.49
2fcnB-4nsmA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 4

(Mus musculus) 		no annotation 4 LEU A1557
GLN A1552
GLU A1550
ILE A1551
 None
 1.04A 2fcnA-4otnA:
undetectable
2fcnB-4otnA:
undetectable		 2fcnA-4otnA:
22.66
2fcnB-4otnA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qe0 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16446
(DUF5043) 		4 LEU A 179
GLU A 174
ILE A 173
PRO A 172
 None
SO4  A 308 (-3.0A)
MLY  A 171 ( 4.3A)
MLY  A 171 ( 2.6A)
 1.11A 2fcnA-4qe0A:
undetectable
2fcnB-4qe0A:
undetectable		 2fcnA-4qe0A:
17.39
2fcnB-4qe0A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ERYTHROCYTE-BINDING
ANTIGEN-175

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 LEU A  91
GLU A 153
ILE A 169
PRO A 170
 None
 1.03A 2fcnA-4qexA:
undetectable
2fcnB-4qexA:
undetectable		 2fcnA-4qexA:
7.86
2fcnB-4qexA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 234
GLU A 424
ILE A 425
PRO A 426
 None
 1.03A 2fcnA-4ud8A:
undetectable
2fcnB-4ud8A:
undetectable		 2fcnA-4ud8A:
10.15
2fcnB-4ud8A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsh ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 GLN B 211
GLU B 210
ILE B 113
PRO B 156
 None
 1.09A 2fcnA-4xshB:
undetectable
2fcnB-4xshB:
undetectable		 2fcnA-4xshB:
17.65
2fcnB-4xshB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		4 LEU A 149
GLN A 204
ILE A 200
PRO A 201
 None
 1.03A 2fcnA-4zk6A:
undetectable
2fcnB-4zk6A:
undetectable		 2fcnA-4zk6A:
15.12
2fcnB-4zk6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A 233
GLU A 235
ILE A 234
PRO A 337
 None
 1.06A 2fcnA-5ahkA:
undetectable
2fcnB-5ahkA:
undetectable		 2fcnA-5ahkA:
9.78
2fcnB-5ahkA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 1.08A 2fcnA-5b83A:
15.7
2fcnB-5b83A:
15.4		 2fcnA-5b83A:
28.63
2fcnB-5b83A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 107
GLU A 110
ILE A 112
PRO A 113
 None
 0.59A 2fcnA-5b83A:
15.7
2fcnB-5b83A:
15.4		 2fcnA-5b83A:
28.63
2fcnB-5b83A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 183
GLU A 186
ILE A 188
PRO A 189
 None
 0.29A 2fcnA-5b83A:
15.7
2fcnB-5b83A:
15.4		 2fcnA-5b83A:
28.63
2fcnB-5b83A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 259
GLU A 262
ILE A 264
PRO A 265
 None
 0.38A 2fcnA-5b83A:
15.7
2fcnB-5b83A:
15.4		 2fcnA-5b83A:
28.63
2fcnB-5b83A:
28.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c7m POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.59A 2fcnA-5c7mB:
15.3
2fcnB-5c7mB:
14.8		 2fcnA-5c7mB:
80.26
2fcnB-5c7mB:
80.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 LEU A 646
GLN A 449
GLU A 494
ILE A 450
 None
 1.10A 2fcnA-5e86A:
undetectable
2fcnB-5e86A:
undetectable		 2fcnA-5e86A:
18.22
2fcnB-5e86A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 LEU A 372
GLU A 323
ILE A 430
PRO A 319
 None
 1.10A 2fcnA-5e9jA:
undetectable
2fcnB-5e9jA:
undetectable		 2fcnA-5e9jA:
14.29
2fcnB-5e9jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		4 LEU A 372
GLU A 323
ILE A 466
PRO A 319
 None
 1.07A 2fcnA-5e9wA:
undetectable
2fcnB-5e9wA:
undetectable		 2fcnA-5e9wA:
12.37
2fcnB-5e9wA:
12.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.33A 2fcnA-5h07A:
15.7
2fcnB-5h07A:
15.2		 2fcnA-5h07A:
32.89
2fcnB-5h07A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 131
GLU A 134
ILE A 136
PRO A 137
 None
 0.46A 2fcnA-5h07A:
15.7
2fcnB-5h07A:
15.2		 2fcnA-5h07A:
32.89
2fcnB-5h07A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 231
GLU A 234
ILE A 236
PRO A 237
 None
 0.95A 2fcnA-5h07A:
15.7
2fcnB-5h07A:
15.2		 2fcnA-5h07A:
32.89
2fcnB-5h07A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpk UBIQUITIN VARIANT
NL.1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.51A 2fcnA-5hpkB:
15.7
2fcnB-5hpkB:
15.5		 2fcnA-5hpkB:
73.81
2fcnB-5hpkB:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hps UBIQUITIN VARIANT
P1.1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.57A 2fcnA-5hpsB:
16.0
2fcnB-5hpsB:
15.5		 2fcnA-5hpsB:
73.17
2fcnB-5hpsB:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpt UBIQUITIN VARIANT
P2.3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.41A 2fcnA-5hptB:
15.8
2fcnB-5hptB:
15.4		 2fcnA-5hptB:
79.01
2fcnB-5hptB:
79.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu7 PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 LEU A2981
GLN A2987
GLU A2989
PRO A2984
 None
 1.10A 2fcnA-5hu7A:
undetectable
2fcnB-5hu7A:
undetectable		 2fcnA-5hu7A:
13.79
2fcnB-5hu7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 GLN A 362
GLU A 365
ILE A 361
PRO A 358
 None
 0.89A 2fcnA-5hucA:
undetectable
2fcnB-5hucA:
undetectable		 2fcnA-5hucA:
9.93
2fcnB-5hucA:
9.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ibk POLYUBIQUITIN-B

(Homo sapiens) 		no annotation 4 GLN F  31
GLU F  34
ILE F  36
PRO F  37
 None
 0.36A 2fcnA-5ibkF:
15.4
2fcnB-5ibkF:
15.4		 2fcnA-5ibkF:
74.36
2fcnB-5ibkF:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 GLN A 294
GLU A 292
ILE A 295
PRO A 296
 None
 1.10A 2fcnA-5iwzA:
undetectable
2fcnB-5iwzA:
undetectable		 2fcnA-5iwzA:
13.30
2fcnB-5iwzA:
13.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jg6 POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.35A 2fcnA-5jg6B:
16.0
2fcnB-5jg6B:
16.4		 2fcnA-5jg6B:
71.95
2fcnB-5jg6B:
71.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr9 NEQ131

(Nanoarchaeum
equitans) 		PF01997
(Translin) 		4 LEU B  58
GLN B  62
GLU B  64
ILE B  63
 None
 0.97A 2fcnA-5jr9B:
undetectable
2fcnB-5jr9B:
undetectable		 2fcnA-5jr9B:
16.59
2fcnB-5jr9B:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ARG X 256
GLN X 193
GLU X 194
ILE X 197
 None
 1.04A 2fcnA-5liyX:
undetectable
2fcnB-5liyX:
undetectable		 2fcnA-5liyX:
15.29
2fcnB-5liyX:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 LEU A 371
GLN A 369
ILE A 352
PRO A 368
 None
 0.83A 2fcnA-5lykA:
undetectable
2fcnB-5lykA:
undetectable		 2fcnA-5lykA:
18.13
2fcnB-5lykA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o6t POLYUBIQUITIN-B

(Homo sapiens) 		no annotation 4 GLN C  31
GLU C  34
ILE C  36
PRO C  37
 None
 0.48A 2fcnA-5o6tC:
12.2
2fcnB-5o6tC:
12.1		 2fcnA-5o6tC:
72.15
2fcnB-5o6tC:
72.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o76 UBV.PCBL UBIQUITIN
VARIANT

(Homo sapiens) 		no annotation 4 GLN E  31
GLU E  34
ILE E  36
PRO E  37
 None
 0.62A 2fcnA-5o76E:
15.7
2fcnB-5o76E:
15.5		 2fcnA-5o76E:
74.39
2fcnB-5o76E:
74.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L42,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ARG c 259
GLU c 283
ILE a  67
PRO a  68
 None
 1.03A 2fcnA-5oolc:
undetectable
2fcnB-5oolc:
undetectable		 2fcnA-5oolc:
12.89
2fcnB-5oolc:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 ARG A1229
LEU A1392
GLN A1343
GLU A1341
 None
 0.97A 2fcnA-5tj2A:
undetectable
2fcnB-5tj2A:
undetectable		 2fcnA-5tj2A:
8.39
2fcnB-5tj2A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2u HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		PF02861
(Clp_N) 		4 LEU A 147
GLN A 143
GLU A  56
ILE A  55
 None
 1.11A 2fcnA-5u2uA:
undetectable
2fcnB-5u2uA:
undetectable		 2fcnA-5u2uA:
18.47
2fcnB-5u2uA:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ucl POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.54A 2fcnA-5uclA:
14.9
2fcnB-5uclA:
14.9		 2fcnA-5uclA:
70.93
2fcnB-5uclA:
70.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v5g UBIQUITIN VARIANT
CC.4

(synthetic
construct) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.48A 2fcnA-5v5gB:
15.4
2fcnB-5v5gB:
15.3		 2fcnA-5v5gB:
73.91
2fcnB-5v5gB:
73.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.34A 2fcnA-5vixA:
16.1
2fcnB-5vixA:
15.8		 2fcnA-5vixA:
90.00
2fcnB-5vixA:
90.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 GLN A 107
GLU A 110
ILE A 112
PRO A 113
 None
 0.42A 2fcnA-5vixA:
16.1
2fcnB-5vixA:
15.8		 2fcnA-5vixA:
90.00
2fcnB-5vixA:
90.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp0 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Aliivibrio
fischeri) 		PF02540
(NAD_synthase) 		4 LEU A  40
GLN A  58
ILE A  98
PRO A 100
 None
 0.86A 2fcnA-5wp0A:
undetectable
2fcnB-5wp0A:
undetectable		 2fcnA-5wp0A:
11.72
2fcnB-5wp0A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Sulfolobus
acidocaldarius) 		no annotation 4 LEU A  23
GLN A  86
ILE A  85
PRO A  82
 None
 1.03A 2fcnA-5yeqA:
undetectable
2fcnB-5yeqA:
undetectable		 2fcnA-5yeqA:
undetectable
2fcnB-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 4 ARG A 482
LEU A 494
ILE A 455
PRO A 456
 None
 1.03A 2fcnA-5yudA:
undetectable
2fcnB-5yudA:
undetectable		 2fcnA-5yudA:
undetectable
2fcnB-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6alk -

(-) 		no annotation 4 LEU A  95
GLN A 132
GLU A 130
ILE A 133
 None
 1.10A 2fcnA-6alkA:
undetectable
2fcnB-6alkA:
undetectable		 2fcnA-6alkA:
undetectable
2fcnB-6alkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byh POLYUBIQUITIN-B

(Homo sapiens) 		no annotation 4 GLN C  31
GLU C  34
ILE C  36
PRO C  37
 None
 0.45A 2fcnA-6byhC:
15.1
2fcnB-6byhC:
15.0		 2fcnA-6byhC:
undetectable
2fcnB-6byhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 4 ARG A 267
LEU A 174
GLU A 294
ILE A 290
 None
 1.03A 2fcnA-6cxdA:
undetectable
2fcnB-6cxdA:
undetectable		 2fcnA-6cxdA:
undetectable
2fcnB-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 4 LEU A 733
GLU A 739
ILE A 738
PRO A 651
 None
 1.11A 2fcnA-6f2tA:
undetectable
2fcnB-6f2tA:
undetectable		 2fcnA-6f2tA:
undetectable
2fcnB-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 243
GLN A 251
ILE A 250
PRO A 247
 None
 1.06A 2fcnA-6fnuA:
undetectable
2fcnB-6fnuA:
undetectable		 2fcnA-6fnuA:
undetectable
2fcnB-6fnuA:
undetectable