SIMILAR PATTERNS OF AMINO ACIDS FOR 2FCN_A_DVAA35

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 GLN A 256
GLU A 107
ILE A 109
PRO A 255
 None
 1.35A 2fcnA-1fcdA:
undetectable		 2fcnA-1fcdA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		4 GLN A 155
GLU A 152
ILE A 151
PRO A 171
 None
 1.15A 2fcnA-1ihpA:
undetectable		 2fcnA-1ihpA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sax METHICILLIN
RESISTANCE
REGULATORY PROTEIN
MECI

(Staphylococcus
aureus) 		PF03965
(Penicillinase_R) 		4 GLN A  35
GLU A  14
ILE A  45
PRO A  42
 None
 1.49A 2fcnA-1saxA:
undetectable		 2fcnA-1saxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu2 APOCYTOCHROME F

(Nostoc sp. PCC
7119) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 GLN B  38
GLU B 246
ILE B 247
PRO B  37
 None
 1.49A 2fcnA-1tu2B:
undetectable		 2fcnA-1tu2B:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yx5 UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.02A 2fcnA-1yx5B:
15.7		 2fcnA-1yx5B:
97.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLN A 225
GLU A 285
ILE A 284
PRO A 221
 None
 1.49A 2fcnA-2cvoA:
undetectable		 2fcnA-2cvoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fim TUBBY RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		4 GLN A 348
GLU A 349
ILE A 384
PRO A 383
 None
 1.40A 2fcnA-2fimA:
undetectable		 2fcnA-2fimA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kdi UBIQUITIN, VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN 27 FUSION
PROTEIN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02809
(UIM) 		4 GLN A  40
GLU A  43
ILE A  45
PRO A  46
 None
 1.14A 2fcnA-2kdiA:
10.7		 2fcnA-2kdiA:
80.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pih PROTEIN YMCA

(Bacillus
subtilis) 		PF06133
(Com_YlbF) 		4 GLN A  89
GLU A  83
ILE A  85
PRO A  86
 None
 1.47A 2fcnA-2pihA:
undetectable		 2fcnA-2pihA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLN A 169
GLU A 229
ILE A 228
PRO A 165
 None
 1.44A 2fcnA-2q49A:
undetectable		 2fcnA-2q49A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 GLN A 127
GLU A 126
ILE A 128
PRO A 129
 None
 0.99A 2fcnA-2xdrA:
undetectable		 2fcnA-2xdrA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 GLN A 263
GLU A 266
ILE A 268
PRO A 269
 None
 0.91A 2fcnA-3ai5A:
16.0		 2fcnA-3ai5A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		4 GLN A  51
GLU A  53
ILE A  52
PRO A  47
 AMP  A 300 (-3.3A)
None
None
None
 1.21A 2fcnA-3berA:
undetectable		 2fcnA-3berA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 GLN A 147
GLU A 169
ILE A 149
PRO A 122
 None
 1.36A 2fcnA-3c24A:
undetectable		 2fcnA-3c24A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5n TUBBY-RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		4 GLN A 348
GLU A 349
ILE A 384
PRO A 383
 None
 1.30A 2fcnA-3c5nA:
undetectable		 2fcnA-3c5nA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f13 PUTATIVE NUDIX
HYDROLASE FAMILY
MEMBER

(Chromobacterium
violaceum) 		PF00293
(NUDIX) 		4 GLN A  99
GLU A 101
ILE A 102
PRO A  98
 None
 1.44A 2fcnA-3f13A:
2.2		 2fcnA-3f13A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kao TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Staphylococcus
aureus) 		PF01791
(DeoC) 		4 GLN A  48
GLU A  50
ILE A  49
PRO A  44
 None
 1.47A 2fcnA-3kaoA:
undetectable		 2fcnA-3kaoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfd TRANSFORMING GROWTH
FACTOR BETA-1

(Homo sapiens) 		PF00019
(TGF_beta) 		4 GLN A 100
GLU A  99
ILE A  88
PRO A  87
 None
 1.41A 2fcnA-3kfdA:
undetectable		 2fcnA-3kfdA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3k UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.02A 2fcnA-3n3kB:
16.2		 2fcnA-3n3kB:
78.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obf PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Paenarthrobacter
aurescens) 		PF01614
(IclR) 		4 GLN A 164
GLU A 163
ILE A 165
PRO A 166
 None
 1.03A 2fcnA-3obfA:
undetectable		 2fcnA-3obfA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 GLN A 132
GLU A 134
ILE A 133
PRO A 112
 None
 1.30A 2fcnA-3op7A:
undetectable		 2fcnA-3op7A:
15.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN

(Bacillus
amyloliquefaciens;
Homo sapiens) 		PF00240
(ubiquitin)
PF00545
(Ribonuclease) 		4 GLN A 135
GLU A 138
ILE A 140
PRO A 141
 None
 0.84A 2fcnA-3q3fA:
14.0		 2fcnA-3q3fA:
44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 GLN A  89
GLU A 164
ILE A 208
PRO A 209
 None
 1.08A 2fcnA-3q3hA:
undetectable		 2fcnA-3q3hA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 GLN A 380
GLU A 496
ILE A 497
PRO A 498
 None
 1.42A 2fcnA-3sqlA:
undetectable		 2fcnA-3sqlA:
11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 GLN A 131
GLU A 134
ILE A 136
PRO A 137
 None
 0.90A 2fcnA-3vdzA:
16.1		 2fcnA-3vdzA:
94.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLN A 154
GLU A 128
ILE A 127
PRO A 152
 None
 1.34A 2fcnA-3zynA:
undetectable		 2fcnA-3zynA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2z OXYSTEROL-BINDING
PROTEIN HOMOLOG 6

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		4 GLN A 403
GLU A 401
ILE A 404
PRO A 169
 None
 1.44A 2fcnA-4b2zA:
undetectable		 2fcnA-4b2zA:
12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gsw UBIQUITIN

(Entamoeba
histolytica) 		PF00240
(ubiquitin) 		4 GLN A  34
GLU A  37
ILE A  39
PRO A  40
 None
 0.86A 2fcnA-4gswA:
15.5		 2fcnA-4gswA:
83.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.93A 2fcnA-4ii2B:
13.9		 2fcnA-4ii2B:
77.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.92A 2fcnA-4ii3B:
14.7		 2fcnA-4ii3B:
86.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 GLN A 287
GLU A 267
ILE A 289
PRO A 288
 None
None
None
NI  A 401 (-4.1A)
 1.41A 2fcnA-4j8lA:
undetectable		 2fcnA-4j8lA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		4 GLN A 317
GLU A 314
ILE A 316
PRO A 371
 None
 1.28A 2fcnA-4js1A:
undetectable		 2fcnA-4js1A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwc CHAPERONE PROTEIN
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 GLN A 442
GLU A 511
ILE A 512
PRO A 396
 None
 1.37A 2fcnA-4jwcA:
undetectable		 2fcnA-4jwcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq2 PUTATIVE
PHYCOERYTHRIN LYASE

(Guillardia
theta) 		PF09367
(CpeS) 		4 GLN A  -8
GLU A  -3
ILE A  -4
PRO A  -9
 None
 1.33A 2fcnA-4tq2A:
undetectable		 2fcnA-4tq2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsh ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 GLN B 211
GLU B 210
ILE B 113
PRO B 156
 None
 1.35A 2fcnA-4xshB:
undetectable		 2fcnA-4xshB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 GLN A 348
GLU A 350
ILE A 349
PRO A 318
 None
 1.42A 2fcnA-4xwlA:
undetectable		 2fcnA-4xwlA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 GLN A 310
GLU A 331
ILE A 332
PRO A 311
 None
 1.37A 2fcnA-4zg7A:
undetectable		 2fcnA-4zg7A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLN A 155
GLU A 153
ILE A 152
PRO A 149
 None
 1.48A 2fcnA-5a3fA:
undetectable		 2fcnA-5a3fA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 107
GLU A 110
ILE A 112
PRO A 113
 None
 0.98A 2fcnA-5b83A:
13.8		 2fcnA-5b83A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 183
GLU A 186
ILE A 188
PRO A 189
 None
 0.90A 2fcnA-5b83A:
13.8		 2fcnA-5b83A:
28.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c7j POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN C  31
GLU C  34
ILE C  36
PRO C  37
 None
 0.69A 2fcnA-5c7jC:
13.9		 2fcnA-5c7jC:
79.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c7m POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.02A 2fcnA-5c7mB:
15.3		 2fcnA-5c7mB:
80.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e10 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		4 GLN A 476
GLU A 428
ILE A 429
PRO A 472
 None
 1.42A 2fcnA-5e10A:
undetectable		 2fcnA-5e10A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 GLN A 717
GLU A 713
ILE A 714
PRO A 253
 None
 1.42A 2fcnA-5e3cA:
undetectable		 2fcnA-5e3cA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvk VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4
VPS4-ASSOCIATED
PROTEIN 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04212
(MIT)
no annotation 		4 GLN A  15
GLU A  12
ILE A  11
PRO C 199
 None
 1.26A 2fcnA-5fvkA:
undetectable		 2fcnA-5fvkA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 131
GLU A 134
ILE A 136
PRO A 137
 None
 0.96A 2fcnA-5h07A:
15.7		 2fcnA-5h07A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN A 231
GLU A 234
ILE A 236
PRO A 237
 None
 0.98A 2fcnA-5h07A:
15.7		 2fcnA-5h07A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpk UBIQUITIN VARIANT
NL.1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.01A 2fcnA-5hpkB:
15.7		 2fcnA-5hpkB:
73.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hps UBIQUITIN VARIANT
P1.1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.07A 2fcnA-5hpsB:
16.0		 2fcnA-5hpsB:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 GLN A 362
GLU A 365
ILE A 361
PRO A 358
 None
 1.06A 2fcnA-5hucA:
undetectable		 2fcnA-5hucA:
9.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ibk POLYUBIQUITIN-B

(Homo sapiens) 		no annotation 4 GLN F  31
GLU F  34
ILE F  36
PRO F  37
 None
 0.91A 2fcnA-5ibkF:
15.4		 2fcnA-5ibkF:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus) 		no annotation 4 GLN A1466
GLU A1438
ILE A1384
PRO A1383
 EDO  A1901 (-4.1A)
None
None
None
 1.06A 2fcnA-5ic1A:
undetectable		 2fcnA-5ic1A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 GLN A 294
GLU A 292
ILE A 295
PRO A 296
 None
 0.89A 2fcnA-5iwzA:
undetectable		 2fcnA-5iwzA:
13.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jg6 POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.91A 2fcnA-5jg6B:
16.0		 2fcnA-5jg6B:
71.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 GLN A 533
GLU A 535
ILE A 534
PRO A 529
 None
 1.32A 2fcnA-5k9tA:
undetectable		 2fcnA-5k9tA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 GLN B 347
GLU B 419
ILE B 432
PRO B 431
 None
 1.34A 2fcnA-5of4B:
undetectable		 2fcnA-5of4B:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLN A  94
GLU A  99
ILE A  98
PRO A 106
 None
 1.44A 2fcnA-5tf0A:
undetectable		 2fcnA-5tf0A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 GLN A 175
GLU A 225
ILE A 226
PRO A 227
 None
 1.14A 2fcnA-5tqrA:
undetectable		 2fcnA-5tqrA:
9.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 GLN A  31
GLU A  34
ILE A  36
PRO A  37
 None
 0.88A 2fcnA-5vixA:
16.1		 2fcnA-5vixA:
90.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 GLN A 107
GLU A 110
ILE A 112
PRO A 113
 None
 0.91A 2fcnA-5vixA:
16.1		 2fcnA-5vixA:
90.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN G 353
GLU G 358
ILE G 354
PRO G 352
 None
 1.48A 2fcnA-5x6oG:
undetectable		 2fcnA-5x6oG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byh POLYUBIQUITIN-B

(Homo sapiens) 		no annotation 4 GLN C  31
GLU C  34
ILE C  36
PRO C  37
 None
 0.97A 2fcnA-6byhC:
15.1		 2fcnA-6byhC:
undetectable