SIMILAR PATTERNS OF AMINO ACIDS FOR 2FB2_B_SAMB501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma) 		4 TYR C 190
SER C 152
VAL C 154
MET C  44
 None
 1.12A 2fb2B-1e6vC:
undetectable		 2fb2B-1e6vC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 471
THR A 527
SER A 544
VAL A 563
 None
 1.09A 2fb2B-1e8tA:
undetectable		 2fb2B-1e8tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 THR A 204
THR A 201
SER A 197
VAL A 153
 None
 1.13A 2fb2B-1fftA:
undetectable		 2fb2B-1fftA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 TYR A 169
THR A 207
THR A 204
MET A 150
 NAP  A 263 (-4.4A)
None
NAP  A 263 ( 3.9A)
None
 1.06A 2fb2B-1h5qA:
2.3		 2fb2B-1h5qA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 TYR A 255
THR A  97
VAL A  57
MET A 183
 None
 1.17A 2fb2B-1i5pA:
undetectable		 2fb2B-1i5pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		4 TYR A 127
GLU A  68
THR A  89
VAL A 156
 None
 1.07A 2fb2B-1rpwA:
undetectable		 2fb2B-1rpwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 575
THR A 728
SER A 510
VAL A 372
 None
 1.16A 2fb2B-1rrhA:
undetectable		 2fb2B-1rrhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 THR A 380
GLU A 227
SER A 350
VAL A 318
 None
 1.22A 2fb2B-1serA:
undetectable		 2fb2B-1serA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 283
THR A  81
THR A 302
VAL A 268
 None
 1.07A 2fb2B-1t5cA:
undetectable		 2fb2B-1t5cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 134
THR A 130
SER A  91
VAL A  96
 None
 1.08A 2fb2B-1tt7A:
undetectable		 2fb2B-1tt7A:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		7 TYR A  30
THR A  73
GLU A  76
THR A 102
SER A 126
VAL A 167
MET A 197
 SAM  A1501 ( 4.5A)
SAM  A1501 (-4.0A)
SAM  A1501 (-4.4A)
SAM  A1501 (-4.3A)
SAM  A1501 ( 2.4A)
SAM  A1501 (-4.5A)
DTU  A1502 (-4.2A)
 0.25A 2fb2B-1tv8A:
51.6		 2fb2B-1tv8A:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		4 TYR A 115
GLU A  85
SER A 175
VAL A 154
 None
 1.13A 2fb2B-1ve4A:
undetectable		 2fb2B-1ve4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 TYR A  49
THR A  66
THR A  67
VAL A  44
 None
 0.93A 2fb2B-1wcxA:
undetectable		 2fb2B-1wcxA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 THR A  19
THR A 156
VAL A 139
MET A 437
 None
 1.12A 2fb2B-1z2zA:
undetectable		 2fb2B-1z2zA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		4 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.90A 2fb2B-1zbsA:
undetectable		 2fb2B-1zbsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 THR A 169
THR A 369
SER A 249
VAL A 343
 None
 1.08A 2fb2B-2b0tA:
undetectable		 2fb2B-2b0tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 TYR A 560
THR A 256
THR A 258
VAL A 531
 None
 1.20A 2fb2B-2b3xA:
undetectable		 2fb2B-2b3xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 4 THR P 102
GLU P 108
VAL P 319
MET P  61
 None
 1.17A 2fb2B-2btvP:
undetectable		 2fb2B-2btvP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like) 		4 THR A 322
SER A 316
VAL A 260
MET A  62
 None
 1.23A 2fb2B-2cw6A:
6.1		 2fb2B-2cw6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 TYR X  89
GLU X 550
THR X 381
SER X 385
 None
 1.15A 2fb2B-2epkX:
5.1		 2fb2B-2epkX:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 TYR A  42
THR A 318
GLU A  48
VAL A  37
 None
 1.18A 2fb2B-2f8qA:
2.9		 2fb2B-2f8qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 THR A 365
THR A 327
SER A 310
VAL A 295
 None
 0.92A 2fb2B-2ggqA:
2.2		 2fb2B-2ggqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 TYR A 471
THR A 364
SER A 371
VAL A 400
 None
 1.13A 2fb2B-2hb6A:
undetectable		 2fb2B-2hb6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 TYR A 489
THR A 165
VAL A 161
MET A 182
 None
 1.13A 2fb2B-2j6lA:
undetectable		 2fb2B-2j6lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 TYR A 435
GLU A 351
THR A  16
VAL A  73
 None
IDE  A1446 (-2.5A)
None
None
 1.16A 2fb2B-2j7cA:
3.6		 2fb2B-2j7cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 TYR A 458
GLU A 375
THR A  15
VAL A  68
 None
 1.16A 2fb2B-2pbgA:
3.7		 2fb2B-2pbgA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		4 TYR A 282
THR A 437
GLU A 387
VAL A 286
 None
 1.22A 2fb2B-2pftA:
undetectable		 2fb2B-2pftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 THR A 180
GLU A 178
THR A 182
VAL A 158
 None
 1.10A 2fb2B-2ph1A:
3.1		 2fb2B-2ph1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 352
THR A 365
GLU A 369
SER A 269
 None
 0.93A 2fb2B-2r66A:
undetectable		 2fb2B-2r66A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux0 CALCIUM-CALMODULIN
DEPENDENT PROTEIN
KINASE (CAM KINASE)
II GAMMA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 TYR A 516
THR A 461
THR A 484
SER A 498
 None
 1.07A 2fb2B-2ux0A:
undetectable		 2fb2B-2ux0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		4 TYR A 287
THR A  92
THR A 306
VAL A 274
 None
 1.20A 2fb2B-2vvgA:
undetectable		 2fb2B-2vvgA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		4 TYR A 487
THR A 398
GLU A 396
THR A 399
 None
 1.18A 2fb2B-2w2gA:
undetectable		 2fb2B-2w2gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 TYR C 296
THR C  86
THR C 315
VAL C 283
 None
 1.10A 2fb2B-2wbeC:
undetectable		 2fb2B-2wbeC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 TYR A 285
THR A  87
THR A 304
VAL A 271
 None
 1.03A 2fb2B-2y5wA:
undetectable		 2fb2B-2y5wA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 292
THR A  91
THR A 311
VAL A 278
 None
 1.18A 2fb2B-3b6uA:
undetectable		 2fb2B-3b6uA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 317
THR A  92
THR A 336
VAL A 303
 None
 1.11A 2fb2B-3b6vA:
undetectable		 2fb2B-3b6vA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		4 THR A  73
GLU A 107
SER A 131
VAL A 198
 None
 1.07A 2fb2B-3bblA:
undetectable		 2fb2B-3bblA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctm CARBONYL REDUCTASE

(Candida
parapsilosis) 		PF13561
(adh_short_C2) 		4 TYR A  54
THR A 265
SER A 166
VAL A 116
 None
 1.14A 2fb2B-3ctmA:
3.1		 2fb2B-3ctmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		4 GLU A 195
SER A 219
VAL A 217
MET A 208
 GOL  A   4 (-2.7A)
None
None
None
 1.16A 2fb2B-3d02A:
undetectable		 2fb2B-3d02A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 704
GLU A 689
SER A 124
VAL A 206
 None
 1.05A 2fb2B-3ddrA:
undetectable		 2fb2B-3ddrA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		4 TYR A 281
THR A 304
THR A 153
SER A 120
 None
 1.21A 2fb2B-3g0iA:
undetectable		 2fb2B-3g0iA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A
EIF3C

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11)
PF00203
(Ribosomal_S19) 		4 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.08A 2fb2B-3japo:
undetectable		 2fb2B-3japo:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00225
(Kinesin)
PF00225
(Kinesin) 		4 TYR B 279
THR A  81
THR B 298
VAL B 265
 None
 1.13A 2fb2B-3kinB:
undetectable		 2fb2B-3kinB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 TYR A 373
THR A 392
THR A 369
VAL A 234
 None
 1.21A 2fb2B-3my7A:
undetectable		 2fb2B-3my7A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		4 TYR A 169
GLU A  10
SER A  21
VAL A 308
 None
 1.03A 2fb2B-3qv2A:
undetectable		 2fb2B-3qv2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 GLU A 321
THR A 306
SER A 329
VAL A  72
 None
 1.02A 2fb2B-3r75A:
2.1		 2fb2B-3r75A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 THR A 314
GLU A 321
SER A 329
VAL A  72
 None
 1.11A 2fb2B-3r75A:
2.1		 2fb2B-3r75A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 326
THR A   7
GLU A  42
SER A 361
 None
 1.17A 2fb2B-3rr1A:
3.3		 2fb2B-3rr1A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 470
THR A 526
SER A 543
VAL A 562
 None
 0.99A 2fb2B-3t1eA:
undetectable		 2fb2B-3t1eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.17A 2fb2B-3t6cA:
4.5		 2fb2B-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 THR A  33
THR A  38
SER A  42
VAL A 150
 ATP  A 288 (-3.7A)
None
None
None
 1.17A 2fb2B-3ufgA:
undetectable		 2fb2B-3ufgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 TYR A 862
GLU A 668
THR A 846
SER A 731
 None
None
CSO  A 845 ( 4.4A)
CSO  A 845 ( 2.5A)
 1.21A 2fb2B-3zdrA:
2.5		 2fb2B-3zdrA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		4 TYR A 289
THR A  83
THR A 308
VAL A 274
 None
 1.17A 2fb2B-3zfcA:
undetectable		 2fb2B-3zfcA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 TYR A 422
GLU A 338
THR A  14
VAL A  71
 None
GOL  A 902 (-2.5A)
None
None
 1.22A 2fb2B-3zjkA:
3.5		 2fb2B-3zjkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 THR A1232
THR A1229
SER A1225
VAL A 927
 None
 1.23A 2fb2B-4acqA:
undetectable		 2fb2B-4acqA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 301
THR A  90
THR A 320
VAL A 284
 None
 1.07A 2fb2B-4bn2A:
undetectable		 2fb2B-4bn2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 TYR I 547
THR I 216
THR I 217
MET I 415
 None
 1.03A 2fb2B-4c1nI:
undetectable		 2fb2B-4c1nI:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 THR A 384
SER A 381
VAL A 379
MET A 403
 None
 1.19A 2fb2B-4ecnA:
undetectable		 2fb2B-4ecnA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 471
THR A 527
SER A 544
VAL A 563
 None
 1.04A 2fb2B-4fzhA:
undetectable		 2fb2B-4fzhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 THR A 169
GLU A 244
THR A 167
VAL A 250
 None
 1.07A 2fb2B-4gulA:
undetectable		 2fb2B-4gulA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 TYR A 174
THR A 192
SER A 301
VAL A 304
 None
None
CL  A 401 (-3.7A)
None
 1.06A 2fb2B-4ifaA:
undetectable		 2fb2B-4ifaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.13A 2fb2B-4ihcA:
3.6		 2fb2B-4ihcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		4 TYR A  21
GLU A  67
SER A 122
VAL A 165
 SAM  A 504 (-4.6A)
SAM  A 504 (-4.1A)
SAM  A 504 (-2.5A)
SAM  A 504 (-4.7A)
 0.68A 2fb2B-4k37A:
18.5		 2fb2B-4k37A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 THR A 289
GLU A  15
THR A 309
SER A 141
 None
 1.01A 2fb2B-4lb0A:
undetectable		 2fb2B-4lb0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Pyrobaculum
aerophilum) 		PF01135
(PCMT) 		4 GLU A  78
SER A  83
VAL A  33
MET A  40
 SAH  A 500 (-4.3A)
SAH  A 500 (-2.9A)
None
None
 1.14A 2fb2B-4o29A:
undetectable		 2fb2B-4o29A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		4 TYR A 235
THR A 244
THR A 155
SER A 221
 None
PYR  A 402 ( 4.1A)
PYR  A 402 ( 4.9A)
None
 1.11A 2fb2B-4petA:
undetectable		 2fb2B-4petA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Clostridioides
difficile) 		PF01520
(Amidase_3) 		4 THR A 266
GLU A 271
THR A 267
VAL A 237
 None
 1.16A 2fb2B-4rn7A:
undetectable		 2fb2B-4rn7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 TYR A 109
THR A 245
SER A 247
VAL A 279
 None
 0.94A 2fb2B-4s3jA:
3.2		 2fb2B-4s3jA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE

(Populus
trichocarpa) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 GLU A 117
THR A  80
SER A 111
VAL A  73
 None
 1.21A 2fb2B-4ussA:
undetectable		 2fb2B-4ussA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg3 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 4 TYR A 166
THR A 182
THR A 159
VAL A  92
 None
 1.13A 2fb2B-4yg3A:
undetectable		 2fb2B-4yg3A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 THR A 381
THR A 372
SER A 405
VAL A 290
 None
 1.22A 2fb2B-4yswA:
undetectable		 2fb2B-4yswA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		4 THR A 423
GLU A 225
SER A 465
VAL A 474
 None
 1.22A 2fb2B-4yu5A:
undetectable		 2fb2B-4yu5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9x GLUCONATE
5-DEHYDROGENASE

(Streptococcus
pyogenes) 		PF13561
(adh_short_C2) 		4 TYR A 158
THR A 196
THR A 193
MET A 146
 None
 1.09A 2fb2B-4z9xA:
2.2		 2fb2B-4z9xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		4 THR A 173
THR A 375
SER A 253
VAL A 349
 None
 1.18A 2fb2B-4zdaA:
undetectable		 2fb2B-4zdaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.12A 2fb2B-4zm4A:
undetectable		 2fb2B-4zm4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Pseudoalteromonas
atlantica) 		PF03480
(DctP) 		4 TYR A 229
THR A 238
THR A 149
SER A 215
 None
PYR  A 401 (-3.8A)
None
None
 1.21A 2fb2B-5cm6A:
undetectable		 2fb2B-5cm6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 TYR A 151
THR A  59
SER A 137
MET A 381
 None
 1.14A 2fb2B-5du9A:
undetectable		 2fb2B-5du9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		4 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.18A 2fb2B-5enzA:
3.4		 2fb2B-5enzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLU A 147
THR A 242
SER A 506
VAL A 525
 GOL  A 705 (-2.8A)
None
None
None
 1.20A 2fb2B-5gxdA:
undetectable		 2fb2B-5gxdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TYR A 389
GLU A 246
THR A 213
VAL A 339
 None
 1.20A 2fb2B-5h8yA:
undetectable		 2fb2B-5h8yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 THR A 240
GLU A 242
THR A 244
VAL A 196
 None
 1.13A 2fb2B-5hwsA:
undetectable		 2fb2B-5hwsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 THR A 332
THR A 314
SER A 312
VAL A 210
 None
 1.21A 2fb2B-5iwzA:
undetectable		 2fb2B-5iwzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA

(Homo sapiens;
synthetic
construct) 		no annotation 4 TYR B 941
THR B1030
THR B1033
VAL B 930
 None
 1.11A 2fb2B-5jcpB:
undetectable		 2fb2B-5jcpB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 THR A 173
THR A 375
SER A 253
VAL A 349
 None
 1.12A 2fb2B-5kvuA:
undetectable		 2fb2B-5kvuA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 THR A 119
THR A 128
SER A 222
VAL A  70
 None
 1.16A 2fb2B-5l6fA:
undetectable		 2fb2B-5l6fA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldy IG DOMAIN PROTEIN
GROUP 1 DOMAIN
PROTEIN

(Yersinia
pseudotuberculosis) 		PF09134
(Invasin_D3) 		4 TYR A1870
THR A1952
SER A1975
VAL A1947
 None
 1.21A 2fb2B-5ldyA:
undetectable		 2fb2B-5ldyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3

([Candida]
magnoliae) 		no annotation 4 THR A 192
GLU A 211
THR A 190
VAL A 219
 NAP  A 301 (-2.7A)
None
NAP  A 301 (-4.3A)
None
 1.21A 2fb2B-5mlnA:
undetectable		 2fb2B-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 TYR K 398
THR K 176
THR K 417
VAL K 385
 None
 1.22A 2fb2B-5mm7K:
undetectable		 2fb2B-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		4 THR 11056
THR 11045
SER 1 912
VAL 1 906
 None
 1.23A 2fb2B-5mz61:
undetectable		 2fb2B-5mz61:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 TYR A 602
THR A 633
THR A 711
MET A 606
 None
 1.21A 2fb2B-5ur2A:
4.7		 2fb2B-5ur2A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 4 TYR A 221
THR A 289
GLU A 118
VAL A 248
 None
None
None
BLA  A 900 (-4.0A)
 0.88A 2fb2B-5uyrA:
undetectable		 2fb2B-5uyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		4 GLU A 161
THR A 185
SER A 210
VAL A 249
 SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.43A 2fb2B-5v1sA:
22.0		 2fb2B-5v1sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhf 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 TYR V 360
THR V 391
THR V 393
VAL V 334
 None
 1.09A 2fb2B-5vhfV:
undetectable		 2fb2B-5vhfV:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 TYR V 360
THR V 391
THR V 393
VAL V 334
 None
 1.02A 2fb2B-5vhsV:
undetectable		 2fb2B-5vhsV:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		4 TYR A 110
GLU A 155
THR A 186
SER A 210
 SAM  A 504 (-4.8A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
 0.39A 2fb2B-5wggA:
17.7		 2fb2B-5wggA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 4 TYR A 453
GLU A 369
THR A  12
VAL A  69
 None
GOL  A 501 (-3.4A)
None
None
 1.17A 2fb2B-5wkaA:
3.8		 2fb2B-5wkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 THR A  61
THR A  77
SER A  74
MET A  52
 None
 0.99A 2fb2B-5x8zA:
undetectable		 2fb2B-5x8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 THR A 774
THR A 746
SER A 849
MET A 800
 None
 1.16A 2fb2B-5xvmA:
undetectable		 2fb2B-5xvmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 482
THR A 312
SER A 496
VAL A 491
 None
 1.14A 2fb2B-5yfbA:
undetectable		 2fb2B-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 4 THR A  80
THR A  84
VAL A 149
MET A 135
 None
LLP  A 181 ( 4.9A)
None
None
 1.20A 2fb2B-6blgA:
undetectable		 2fb2B-6blgA:
21.73