SIMILAR PATTERNS OF AMINO ACIDS FOR 2FB2_A_SAMA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4e CATALASE A

(Saccharomyces
cerevisiae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 CYH A  90
THR A 133
THR A 102
VAL A 310
 None
 1.12A 2fb2A-1a4eA:
undetectable		 2fb2A-1a4eA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 CYH A 525
THR A 435
GLU A 493
THR A 433
 None
 1.05A 2fb2A-1cu1A:
undetectable		 2fb2A-1cu1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR O 179
GLU O 314
SER O 238
VAL O 240
 SO4  O 338 (-3.5A)
None
None
None
 1.05A 2fb2A-1dbvO:
undetectable		 2fb2A-1dbvO:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 471
THR A 527
SER A 544
VAL A 563
 None
 1.11A 2fb2A-1e8tA:
undetectable		 2fb2A-1e8tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 THR A 204
THR A 201
SER A 197
VAL A 153
 None
 1.13A 2fb2A-1fftA:
undetectable		 2fb2A-1fftA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 CYH A  18
THR A 870
SER A  59
VAL A  40
 None
 1.15A 2fb2A-1h0hA:
undetectable		 2fb2A-1h0hA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 TYR A 169
THR A 207
THR A 204
MET A 150
 NAP  A 263 (-4.4A)
None
NAP  A 263 ( 3.9A)
None
 1.12A 2fb2A-1h5qA:
2.3		 2fb2A-1h5qA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 TYR A 255
THR A  97
VAL A  57
MET A 183
 None
 1.12A 2fb2A-1i5pA:
undetectable		 2fb2A-1i5pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jof CARBOXY-CIS,CIS-MUCO
NATE CYCLASE

(Neurospora
crassa) 		PF10282
(Lactonase) 		4 THR A 306
GLU A 335
THR A 304
VAL A 259
 None
 1.16A 2fb2A-1jofA:
undetectable		 2fb2A-1jofA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		4 TYR A 127
GLU A  68
THR A  89
VAL A 156
 None
 1.05A 2fb2A-1rpwA:
undetectable		 2fb2A-1rpwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 575
THR A 728
SER A 510
VAL A 372
 None
 1.13A 2fb2A-1rrhA:
undetectable		 2fb2A-1rrhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 THR A 380
GLU A 227
SER A 350
VAL A 318
 None
 1.16A 2fb2A-1serA:
undetectable		 2fb2A-1serA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 283
THR A  81
THR A 302
VAL A 268
 None
 1.02A 2fb2A-1t5cA:
undetectable		 2fb2A-1t5cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 134
THR A 130
SER A  91
VAL A  96
 None
 1.08A 2fb2A-1tt7A:
undetectable		 2fb2A-1tt7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 CYH A 356
THR A  44
GLU A  40
VAL A 387
 None
 1.08A 2fb2A-1tufA:
3.3		 2fb2A-1tufA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		8 TYR A  30
CYH A  31
THR A  73
GLU A  76
THR A 102
SER A 126
VAL A 167
MET A 197
 SAM  A1501 ( 4.5A)
SF4  A1401 (-2.3A)
SAM  A1501 (-4.0A)
SAM  A1501 (-4.4A)
SAM  A1501 (-4.3A)
SAM  A1501 ( 2.4A)
SAM  A1501 (-4.5A)
DTU  A1502 (-4.2A)
 0.16A 2fb2A-1tv8A:
53.1		 2fb2A-1tv8A:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		4 TYR A 115
GLU A  85
SER A 175
VAL A 154
 None
 1.15A 2fb2A-1ve4A:
undetectable		 2fb2A-1ve4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 TYR A  49
THR A  66
THR A  67
VAL A  44
 None
 0.92A 2fb2A-1wcxA:
undetectable		 2fb2A-1wcxA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		4 CYH A  90
GLU A  15
SER A 144
VAL A 100
 NI  A 200 (-2.2A)
None
None
None
 1.06A 2fb2A-1ws0A:
undetectable		 2fb2A-1ws0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxq GTP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF08438
(MMR_HSR1_C) 		4 THR A 303
GLU A 307
THR A 249
VAL A   5
 None
 0.94A 2fb2A-1wxqA:
2.4		 2fb2A-1wxqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8y SPIKE GLYCOPROTEIN
E1

(Sindbis virus) 		PF01589
(Alpha_E1_glycop) 		4 THR A 141
THR A 140
SER A 156
VAL A 161
 None
 1.17A 2fb2A-1z8yA:
undetectable		 2fb2A-1z8yA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		4 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.92A 2fb2A-1zbsA:
undetectable		 2fb2A-1zbsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 TYR A 560
THR A 256
THR A 258
VAL A 531
 None
 1.18A 2fb2A-2b3xA:
2.1		 2fb2A-2b3xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 TYR A  42
THR A 318
GLU A  48
VAL A  37
 None
 1.18A 2fb2A-2f8qA:
5.8		 2fb2A-2f8qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		4 CYH A 443
GLU A 452
VAL A 370
MET A 374
 HEM  A 600 (-2.4A)
HEM  A 600 (-4.5A)
HEM  A 600 ( 4.9A)
None
 0.92A 2fb2A-2f9qA:
undetectable		 2fb2A-2f9qA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 THR A 365
THR A 327
SER A 310
VAL A 295
 None
 0.98A 2fb2A-2ggqA:
2.3		 2fb2A-2ggqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 TYR A 489
THR A 165
VAL A 161
MET A 182
 None
 1.13A 2fb2A-2j6lA:
undetectable		 2fb2A-2j6lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 TYR A 435
GLU A 351
THR A  16
VAL A  73
 None
IDE  A1446 (-2.5A)
None
None
 1.16A 2fb2A-2j7cA:
2.5		 2fb2A-2j7cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		4 TYR A 282
THR A 437
GLU A 387
VAL A 286
 None
 1.17A 2fb2A-2pftA:
undetectable		 2fb2A-2pftA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		4 THR A 180
GLU A 178
THR A 182
VAL A 158
 None
 1.16A 2fb2A-2ph1A:
2.8		 2fb2A-2ph1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 352
THR A 365
GLU A 369
SER A 269
 None
 1.01A 2fb2A-2r66A:
undetectable		 2fb2A-2r66A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux0 CALCIUM-CALMODULIN
DEPENDENT PROTEIN
KINASE (CAM KINASE)
II GAMMA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 TYR A 516
THR A 461
THR A 484
SER A 498
 None
 1.05A 2fb2A-2ux0A:
undetectable		 2fb2A-2ux0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		4 TYR A 287
THR A  92
THR A 306
VAL A 274
 None
 1.19A 2fb2A-2vvgA:
undetectable		 2fb2A-2vvgA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 TYR C 296
THR C  86
THR C 315
VAL C 283
 None
 1.06A 2fb2A-2wbeC:
undetectable		 2fb2A-2wbeC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 TYR A 285
THR A  87
THR A 304
VAL A 271
 None
 1.03A 2fb2A-2y5wA:
undetectable		 2fb2A-2y5wA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 292
THR A  91
THR A 311
VAL A 278
 None
 1.17A 2fb2A-3b6uA:
undetectable		 2fb2A-3b6uA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 317
THR A  92
THR A 336
VAL A 303
 None
 1.10A 2fb2A-3b6vA:
undetectable		 2fb2A-3b6vA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		4 THR A  73
GLU A 107
SER A 131
VAL A 198
 None
 1.10A 2fb2A-3bblA:
undetectable		 2fb2A-3bblA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 THR A 226
THR A 150
SER A 142
VAL A  87
 None
 1.10A 2fb2A-3brzA:
undetectable		 2fb2A-3brzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 TYR A  35
CYH A  36
GLU A  79
VAL A 168
 None
SF4  A 500 (-2.2A)
None
None
 0.80A 2fb2A-3c8fA:
14.9		 2fb2A-3c8fA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 THR A 325
THR A 321
SER A 594
MET A 611
 None
 1.17A 2fb2A-3cihA:
undetectable		 2fb2A-3cihA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctm CARBONYL REDUCTASE

(Candida
parapsilosis) 		PF13561
(adh_short_C2) 		4 TYR A  54
THR A 265
SER A 166
VAL A 116
 None
 1.14A 2fb2A-3ctmA:
2.1		 2fb2A-3ctmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A 704
GLU A 689
SER A 124
VAL A 206
 None
 1.06A 2fb2A-3ddrA:
undetectable		 2fb2A-3ddrA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 184
GLU A 317
SER A 242
VAL A 244
 None
 1.14A 2fb2A-3gnqA:
undetectable		 2fb2A-3gnqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri;
Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF02738
(Ald_Xan_dh_C2)
PF00111
(Fer2)
PF01799
(Fer2_2) 		4 CYH D 138
GLU A 187
THR A 234
MET B 219
 FES  D 907 ( 2.4A)
None
None
MCN  B 921 (-3.3A)
 1.05A 2fb2A-3hrdD:
undetectable		 2fb2A-3hrdD:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A
EIF3C

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11)
PF00203
(Ribosomal_S19) 		4 THR o 490
THR o 481
SER p 734
VAL p 777
 None
 1.08A 2fb2A-3japo:
undetectable		 2fb2A-3japo:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN
KINESIN HEAVY CHAIN

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00225
(Kinesin)
PF00225
(Kinesin) 		4 TYR B 279
THR A  81
THR B 298
VAL B 265
 None
 1.12A 2fb2A-3kinB:
undetectable		 2fb2A-3kinB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis) 		PF09754
(PAC2) 		4 CYH A 108
THR A 165
GLU A  99
VAL A 123
 None
CL  A 301 (-4.7A)
None
None
 1.09A 2fb2A-3mnfA:
undetectable		 2fb2A-3mnfA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 TYR A 122
CYH A  89
THR A 360
VAL A 176
 None
 1.00A 2fb2A-3mpgA:
3.8		 2fb2A-3mpgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		4 TYR A 169
GLU A  10
SER A  21
VAL A 308
 None
 1.03A 2fb2A-3qv2A:
undetectable		 2fb2A-3qv2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 THR A 314
GLU A 321
THR A 306
SER A 329
VAL A  72
 None
 1.16A 2fb2A-3r75A:
undetectable		 2fb2A-3r75A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 THR A 131
THR A 130
SER A 359
MET A 506
 None
 1.16A 2fb2A-3sqlA:
3.6		 2fb2A-3sqlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 470
THR A 526
SER A 543
VAL A 562
 None
 0.98A 2fb2A-3t1eA:
undetectable		 2fb2A-3t1eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 322
GLU A 316
SER A 344
VAL A 110
MET A  96
 None
 1.36A 2fb2A-3t6cA:
4.3		 2fb2A-3t6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 THR A  33
THR A  38
SER A  42
VAL A 150
 ATP  A 288 (-3.7A)
None
None
None
 1.14A 2fb2A-3ufgA:
undetectable		 2fb2A-3ufgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		4 TYR A 289
THR A  83
THR A 308
VAL A 274
 None
 1.16A 2fb2A-3zfcA:
undetectable		 2fb2A-3zfcA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 301
THR A  90
THR A 320
VAL A 284
 None
 1.04A 2fb2A-4bn2A:
undetectable		 2fb2A-4bn2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 TYR I 547
THR I 216
THR I 217
MET I 415
 None
 0.97A 2fb2A-4c1nI:
undetectable		 2fb2A-4c1nI:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 TYR A 324
THR A 208
THR A 209
VAL A 328
 None
IPE  A 405 ( 4.6A)
None
None
 1.18A 2fb2A-4e1eA:
undetectable		 2fb2A-4e1eA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ec7 VENOM NERVE GROWTH
FACTOR

(Naja atra) 		PF00243
(NGF) 		4 THR A 104
GLU A  80
THR A  54
SER A  16
 None
 0.97A 2fb2A-4ec7A:
undetectable		 2fb2A-4ec7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 THR A 471
THR A 527
SER A 544
VAL A 563
 None
 1.09A 2fb2A-4fzhA:
undetectable		 2fb2A-4fzhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		4 THR A 169
GLU A 244
THR A 167
VAL A 250
 None
 1.12A 2fb2A-4gulA:
undetectable		 2fb2A-4gulA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 TYR A 174
THR A 192
SER A 301
VAL A 304
 None
None
CL  A 401 (-3.7A)
None
 1.12A 2fb2A-4ifaA:
undetectable		 2fb2A-4ifaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.09A 2fb2A-4ihcA:
2.8		 2fb2A-4ihcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		5 TYR A  21
CYH A  22
GLU A  67
SER A 122
VAL A 165
 SAM  A 504 (-4.6A)
SF4  A 503 ( 2.2A)
SAM  A 504 (-4.1A)
SAM  A 504 (-2.5A)
SAM  A 504 (-4.7A)
 0.69A 2fb2A-4k37A:
18.6		 2fb2A-4k37A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 4 CYH C 102
THR C 133
GLU C  63
THR C 132
 None
 1.12A 2fb2A-4k49C:
undetectable		 2fb2A-4k49C:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 THR A 289
GLU A  15
THR A 309
SER A 141
 None
 1.03A 2fb2A-4lb0A:
undetectable		 2fb2A-4lb0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 CYH A 103
THR A  93
SER A 344
VAL A 355
 None
None
GOL  A 404 (-2.7A)
None
 0.95A 2fb2A-4lmpA:
undetectable		 2fb2A-4lmpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nji 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Burkholderia
multivorans) 		PF13394
(Fer4_14) 		4 CYH A  49
THR A  90
GLU A  93
VAL A 151
 SF4  A 301 ( 2.2A)
2K8  A 303 ( 2.9A)
SAM  A 302 (-4.2A)
SAM  A 302 (-4.5A)
 0.67A 2fb2A-4njiA:
8.7		 2fb2A-4njiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 383
GLU A 313
THR A 333
VAL A 202
 None
GLC  A1006 (-4.7A)
None
None
 1.13A 2fb2A-4okdA:
3.2		 2fb2A-4okdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		4 TYR A 235
THR A 244
THR A 155
SER A 221
 None
PYR  A 402 ( 4.1A)
PYR  A 402 ( 4.9A)
None
 1.15A 2fb2A-4petA:
undetectable		 2fb2A-4petA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 4 CYH B 132
GLU B 180
SER B 233
VAL B 280
 SF4  B 401 (-2.1A)
SF4  B 401 ( 4.8A)
SF4  B 401 ( 4.8A)
None
 0.77A 2fb2A-4pl2B:
12.0		 2fb2A-4pl2B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhz CRY23AA1

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 TYR A 159
THR A 125
THR A 126
VAL A 114
 None
 1.15A 2fb2A-4rhzA:
undetectable		 2fb2A-4rhzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Clostridioides
difficile) 		PF01520
(Amidase_3) 		4 THR A 266
GLU A 271
THR A 267
VAL A 237
 None
 1.12A 2fb2A-4rn7A:
undetectable		 2fb2A-4rn7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 TYR A 109
THR A 245
SER A 247
VAL A 279
 None
 0.92A 2fb2A-4s3jA:
3.5		 2fb2A-4s3jA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzk TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Streptomyces
blastmyceticus) 		PF11991
(Trp_DMAT) 		4 TYR A 348
GLU A 106
VAL A 334
MET A 343
 None
 1.19A 2fb2A-4yzkA:
undetectable		 2fb2A-4yzkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9x GLUCONATE
5-DEHYDROGENASE

(Streptococcus
pyogenes) 		PF13561
(adh_short_C2) 		4 TYR A 158
THR A 196
THR A 193
MET A 146
 None
 1.11A 2fb2A-4z9xA:
undetectable		 2fb2A-4z9xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.16A 2fb2A-4zm4A:
undetectable		 2fb2A-4zm4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Corynebacterium
glutamicum) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 CYH A  67
THR A  55
THR A  78
VAL A  89
 None
NAP  A 302 (-4.4A)
NAP  A 302 ( 4.1A)
None
 1.04A 2fb2A-5eesA:
undetectable		 2fb2A-5eesA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enz UDP-GLCNAC
2-EPIMERASE

(Staphylococcus
aureus) 		PF02350
(Epimerase_2) 		4 THR A 280
THR A 203
VAL A 265
MET A 178
 None
UDP  A 401 ( 4.4A)
UDP  A 401 (-3.7A)
None
 1.14A 2fb2A-5enzA:
3.4		 2fb2A-5enzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 243
GLU A 147
THR A 242
SER A 506
VAL A 525
 None
GOL  A 705 (-2.8A)
None
None
None
 1.23A 2fb2A-5gxdA:
undetectable		 2fb2A-5gxdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		4 THR A 328
THR A 366
SER A 229
VAL A 261
 None
 1.18A 2fb2A-5hkjA:
undetectable		 2fb2A-5hkjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		4 CYH A 132
GLU A 180
SER A 233
VAL A 280
 SF4  A 502 ( 2.2A)
MET  A 501 (-4.0A)
MET  A 501 ( 2.6A)
5AD  A 503 (-4.8A)
 0.69A 2fb2A-5hr6A:
12.2		 2fb2A-5hr6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 THR A 240
GLU A 242
THR A 244
VAL A 196
 None
 1.11A 2fb2A-5hwsA:
undetectable		 2fb2A-5hwsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 THR A 332
THR A 314
SER A 312
VAL A 210
 None
 1.16A 2fb2A-5iwzA:
undetectable		 2fb2A-5iwzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA

(Homo sapiens;
synthetic
construct) 		no annotation 4 TYR B 941
THR B1030
THR B1033
VAL B 930
 None
 1.06A 2fb2A-5jcpB:
undetectable		 2fb2A-5jcpB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 THR A 173
THR A 375
SER A 253
VAL A 349
 None
 1.18A 2fb2A-5kvuA:
undetectable		 2fb2A-5kvuA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 THR A 119
THR A 128
SER A 222
VAL A  70
 None
 1.17A 2fb2A-5l6fA:
undetectable		 2fb2A-5l6fA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 TYR K 398
THR K 176
THR K 417
VAL K 385
 None
 1.17A 2fb2A-5mm7K:
undetectable		 2fb2A-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 4 TYR A 253
CYH A 207
THR A 155
VAL A 222
 None
 1.07A 2fb2A-5n94A:
undetectable		 2fb2A-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 CYH A 371
GLU A 224
THR A 149
SER A 145
 None
None
IOS  A1000 ( 3.7A)
IOS  A1000 ( 3.5A)
 1.13A 2fb2A-5nlmA:
3.1		 2fb2A-5nlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		4 CYH 1 111
THR 1 168
GLU 1 102
VAL 1 126
 None
 1.05A 2fb2A-5un01:
undetectable		 2fb2A-5un01:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 4 TYR A 221
THR A 289
GLU A 118
VAL A 248
 None
None
None
BLA  A 900 (-4.0A)
 0.95A 2fb2A-5uyrA:
undetectable		 2fb2A-5uyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		5 CYH A 124
GLU A 161
THR A 185
SER A 210
VAL A 249
 SF4  A 601 ( 2.2A)
SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.71A 2fb2A-5v1sA:
22.0		 2fb2A-5v1sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 TYR V 360
THR V 391
THR V 393
VAL V 334
 None
 1.13A 2fb2A-5vhsV:
undetectable		 2fb2A-5vhsV:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 CYH A  91
GLU A 127
SER A 180
VAL A 224
 SF4  A 401 ( 2.4A)
SAH  A 402 (-4.3A)
SAH  A 402 (-2.4A)
SAH  A 402 (-4.3A)
 0.73A 2fb2A-5vslA:
18.5		 2fb2A-5vslA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		5 TYR A 110
CYH A 111
GLU A 155
THR A 186
SER A 210
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-3.7A)
SAM  A 504 (-4.2A)
SAM  A 504 (-2.5A)
 0.44A 2fb2A-5wggA:
17.8		 2fb2A-5wggA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		4 TYR A 110
CYH A 111
THR A 186
GLU A 155
 SAM  A 504 (-4.8A)
SF4  A 502 ( 2.4A)
SAM  A 504 (-4.2A)
SAM  A 504 (-3.7A)
 1.05A 2fb2A-5wggA:
17.8		 2fb2A-5wggA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus) 		no annotation 4 TYR D  39
CYH D 100
THR D  80
THR D  81
 None
 1.01A 2fb2A-5ybbD:
undetectable		 2fb2A-5ybbD:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 TYR A 482
THR A 312
SER A 496
VAL A 491
 None
 1.14A 2fb2A-5yfbA:
undetectable		 2fb2A-5yfbA:
undetectable