SIMILAR PATTERNS OF AMINO ACIDS FOR 2F94_F_BFQF9001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
7 LEU A 114
ARG A 126
THR A 181
GLN A 185
LYS A 214
THR A 215
TYR A 218
None
0.87A 2f94F-1fpsA:
44.5
2f94F-1fpsA:
69.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
5 LEU A 114
ARG A 126
THR A 215
TYR A 218
GLN A 254
None
0.81A 2f94F-1fpsA:
44.5
2f94F-1fpsA:
69.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
7 LEU A 114
ASP A 117
ARG A 126
THR A 181
GLN A 185
THR A 215
TYR A 218
None
0.77A 2f94F-1fpsA:
44.5
2f94F-1fpsA:
69.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
5 LEU A 114
ASP A 117
ASP A 121
ARG A 126
THR A 215
None
0.78A 2f94F-1fpsA:
44.5
2f94F-1fpsA:
69.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
5 LEU A 114
ASP A 121
ARG A 126
LYS A 214
THR A 215
None
0.96A 2f94F-1fpsA:
44.5
2f94F-1fpsA:
69.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
0.68A 2f94F-1rqjA:
30.1
2f94F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
6 LEU A  79
ASP A  88
ARG A  93
GLN A 154
THR A 178
GLN A 215
None
0.84A 2f94F-1rtrA:
25.6
2f94F-1rtrA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE


(Thermus
thermophilus)
PF00348
(polyprenyl_synt)
6 LEU A  76
ARG A  88
THR A 142
TYR A 176
GLN A 209
ASP A 212
None
0.87A 2f94F-1wmwA:
32.4
2f94F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE


(Thermus
thermophilus)
PF00348
(polyprenyl_synt)
7 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
TYR A 176
GLN A 209
None
0.96A 2f94F-1wmwA:
32.4
2f94F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE


(Thermus
thermophilus)
PF00348
(polyprenyl_synt)
7 LEU A  76
ASP A  83
ARG A  88
THR A 142
GLN A 146
TYR A 176
GLN A 209
None
0.54A 2f94F-1wmwA:
32.4
2f94F-1wmwA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Pyrococcus
horikoshii)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
GLN A 215
None
0.64A 2f94F-1wy0A:
28.8
2f94F-1wy0A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
6 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
None
1.40A 2f94F-2azkA:
23.6
2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
None
1.02A 2f94F-2azkA:
23.6
2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  81
THR A 139
THR A 161
GLN A 197
None
0.87A 2f94F-2azkA:
23.6
2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
6 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
None
0.90A 2f94F-2azkA:
23.6
2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  85
THR A 139
THR A 161
GLN A 197
None
0.64A 2f94F-2azkA:
23.6
2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae)
PF00348
(polyprenyl_synt)
9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
0.44A 2f94F-2dh4A:
14.1
2f94F-2dh4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE


(Thermotoga
maritima)
PF00348
(polyprenyl_synt)
5 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
0.81A 2f94F-2ftzA:
25.2
2f94F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE


(Thermotoga
maritima)
PF00348
(polyprenyl_synt)
5 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
0.42A 2f94F-2ftzA:
25.2
2f94F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
8 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
GLN A 251
None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
0.71A 2f94F-2o1oA:
36.0
2f94F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
LYS A 210
THR A 211
TYR A 214
GLN A 251
None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
0.41A 2f94F-2o1oA:
36.0
2f94F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
6 LEU A  61
ARG A  73
LYS A 151
GLN A 185
ASP A 188
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
GRG  A 500 ( 2.6A)
1.33A 2f94F-2q80A:
16.2
2f94F-2q80A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
8 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.82A 2f94F-2q80A:
16.2
2f94F-2q80A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
7 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.89A 2f94F-2q80A:
16.2
2f94F-2q80A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
6 LEU A  61
ASP A  64
ASP A  68
ARG A  73
THR A 152
GLN A 126
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 4.6A)
GRG  A 500 ( 3.5A)
1.41A 2f94F-2q80A:
16.2
2f94F-2q80A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE


(Arabidopsis
thaliana)
PF00348
(polyprenyl_synt)
6 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
0.61A 2f94F-3aq0A:
25.8
2f94F-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
7 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
1.00A 2f94F-3aqcB:
28.3
2f94F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
7 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
0.78A 2f94F-3aqcB:
28.3
2f94F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE


(Legionella
pneumophila)
PF00348
(polyprenyl_synt)
5 LEU A  91
ASP A 100
ARG A 105
GLN A 168
THR A 193
None
0.79A 2f94F-3lomA:
25.8
2f94F-3lomA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE


(Legionella
pneumophila)
PF00348
(polyprenyl_synt)
5 LEU A  91
ASP A 100
GLN A 168
THR A 193
GLN A 231
None
0.89A 2f94F-3lomA:
25.8
2f94F-3lomA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  87
ARG A  92
GLN A 153
THR A 179
None
0.48A 2f94F-3m0gA:
25.2
2f94F-3m0gA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  87
ARG A  92
LYS A 178
THR A 179
None
0.64A 2f94F-3m0gA:
25.2
2f94F-3m0gA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
5 LEU A  86
ARG A 100
THR A 184
GLN A 221
ASP A 224
GOL  A 310 ( 4.3A)
None
None
None
None
0.88A 2f94F-3m9uA:
25.7
2f94F-3m9uA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE


(Rhodobacter
capsulatus)
PF00348
(polyprenyl_synt)
6 LEU A  90
ASP A  93
ARG A 102
LYS A 179
THR A 180
GLN A 217
None
0.79A 2f94F-3mzvA:
26.4
2f94F-3mzvA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE


(Streptomyces
coelicolor)
PF00348
(polyprenyl_synt)
5 LEU A 125
ASP A 132
ARG A 137
GLN A 193
LYS A 217
None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
SO4  A   3 (-2.8A)
0.87A 2f94F-3nf2A:
26.7
2f94F-3nf2A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE


(Campylobacter
jejuni)
PF00348
(polyprenyl_synt)
5 LEU A  75
ARG A  89
GLN A 149
THR A 173
GLN A 210
None
0.82A 2f94F-3npkA:
26.2
2f94F-3npkA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE


(Campylobacter
jejuni)
PF00348
(polyprenyl_synt)
5 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
None
0.97A 2f94F-3npkA:
26.2
2f94F-3npkA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE


(Campylobacter
jejuni)
PF00348
(polyprenyl_synt)
5 LEU A  75
ASP A  84
ARG A  89
GLN A 149
THR A 173
None
0.49A 2f94F-3npkA:
26.2
2f94F-3npkA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE


(Campylobacter
jejuni)
PF00348
(polyprenyl_synt)
5 LEU A  75
ASP A  84
ARG A  89
LYS A 172
THR A 173
None
0.71A 2f94F-3npkA:
26.2
2f94F-3npkA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE


(Pseudomonas
protegens)
PF00348
(polyprenyl_synt)
6 LEU A  80
ARG A  94
GLN A 157
LYS A 180
THR A 181
GLN A 219
None
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
1.07A 2f94F-3p41A:
24.0
2f94F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE


(Pseudomonas
protegens)
PF00348
(polyprenyl_synt)
7 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
0.75A 2f94F-3p41A:
24.0
2f94F-3p41A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE


(Enterococcus
faecalis)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  82
ARG A  93
GLN A 153
THR A 177
None
1.02A 2f94F-3p8lA:
25.6
2f94F-3p8lA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE


(Enterococcus
faecalis)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  88
ARG A  93
GLN A 153
THR A 177
None
0.49A 2f94F-3p8lA:
25.6
2f94F-3p8lA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE


(Enterococcus
faecalis)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  88
GLN A 153
THR A 177
GLN A 214
None
0.91A 2f94F-3p8lA:
25.6
2f94F-3p8lA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
5 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.86A 2f94F-3pkoA:
25.3
2f94F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
5 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.79A 2f94F-3pkoA:
25.3
2f94F-3pkoA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
9 LEU A  89
ASP A  92
ASP A  98
ARG A 103
LYS A 186
THR A 187
GLN A 225
ASP A 228
LYS A 242
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
0.48A 2f94F-3q1oA:
31.1
2f94F-3q1oA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
9 LEU A  89
ASP A  92
ASP A  98
GLN A 163
LYS A 186
THR A 187
GLN A 225
ASP A 228
LYS A 242
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
0.67A 2f94F-3q1oA:
31.1
2f94F-3q1oA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
7 LEU A 105
ARG A 117
GLN A 191
LYS A 215
THR A 216
GLN A 254
LYS A 271
None
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
DMA  A 384 ( 2.8A)
1.35A 2f94F-3qqvA:
33.8
2f94F-3qqvA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
7 LEU A 105
ASP A 108
ARG A 117
GLN A 191
LYS A 215
THR A 216
GLN A 254
None
MG  A 381 (-2.4A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
0.89A 2f94F-3qqvA:
33.8
2f94F-3qqvA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
7 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
GLN A 254
None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
0.47A 2f94F-3qqvA:
33.8
2f94F-3qqvA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
6 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
TYR A 219
None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 384 ( 4.9A)
0.70A 2f94F-3qqvA:
33.8
2f94F-3qqvA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
5 LEU A  74
ASP A  77
LYS A 162
THR A 163
GLN A 197
None
0.73A 2f94F-3tc1A:
25.9
2f94F-3tc1A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
5 LEU A  74
LYS A 162
THR A 163
GLN A 197
ASP A 200
None
None
None
None
MG  A 500 (-2.9A)
0.51A 2f94F-3tc1A:
25.9
2f94F-3tc1A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  88
ARG A  99
LYS A 185
THR A 186
None
0.98A 2f94F-3ts7A:
24.6
2f94F-3ts7A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  94
ARG A  99
GLN A 162
THR A 186
None
0.60A 2f94F-3ts7A:
24.6
2f94F-3ts7A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  94
ARG A  99
LYS A 185
THR A 186
None
0.68A 2f94F-3ts7A:
24.6
2f94F-3ts7A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE


(Clostridium
perfringens)
PF00348
(polyprenyl_synt)
5 LEU A  88
ASP A  97
ARG A 102
GLN A 163
THR A 188
None
0.49A 2f94F-3ucaA:
26.3
2f94F-3ucaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
6 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
0.92A 2f94F-3wjoA:
25.7
2f94F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
6 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
0.83A 2f94F-3wjoA:
25.7
2f94F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
6 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
0.83A 2f94F-3wjoA:
25.7
2f94F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE


(Pseudomonas
aeruginosa)
PF00348
(polyprenyl_synt)
7 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
0.49A 2f94F-3zouA:
23.6
2f94F-3zouA:
28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
cruzi)
PF00348
(polyprenyl_synt)
12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
0.42A 2f94F-4e1eA:
44.3
2f94F-4e1eA:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE


(Marinomonas sp.
MED121)
PF00348
(polyprenyl_synt)
5 LEU A  80
ASP A  83
ASP A  89
LYS A 178
THR A 179
None
0.73A 2f94F-4f62A:
24.1
2f94F-4f62A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
0.89A 2f94F-4fp4A:
20.8
2f94F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
1.13A 2f94F-4fp4A:
20.8
2f94F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
1.00A 2f94F-4fp4A:
20.8
2f94F-4fp4A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
None
0.86A 2f94F-4gp1A:
28.2
2f94F-4gp1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE


(Pseudoalteromonas
atlantica)
PF00348
(polyprenyl_synt)
5 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
None
0.92A 2f94F-4jxyA:
25.6
2f94F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE


(Pseudoalteromonas
atlantica)
PF00348
(polyprenyl_synt)
5 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
None
0.91A 2f94F-4jxyA:
25.6
2f94F-4jxyA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE


(Leishmania
major)
PF00348
(polyprenyl_synt)
12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
0.37A 2f94F-4jzxA:
44.8
2f94F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA


(Artemisia
spiciformis)
PF00348
(polyprenyl_synt)
7 LEU A  94
ASP A  97
ARG A 106
THR A 161
GLN A 165
THR A 195
TYR A 198
None
0.62A 2f94F-4kk2A:
40.5
2f94F-4kk2A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA


(Artemisia
spiciformis)
PF00348
(polyprenyl_synt)
7 LEU A  94
ASP A  97
ARG A 106
THR A 161
LYS A 194
THR A 195
TYR A 198
None
0.81A 2f94F-4kk2A:
40.5
2f94F-4kk2A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA


(Artemisia
spiciformis)
PF00348
(polyprenyl_synt)
6 LEU A  94
THR A 161
GLN A 165
THR A 195
TYR A 198
GLN A 233
None
0.79A 2f94F-4kk2A:
40.5
2f94F-4kk2A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE


(Zymomonas
mobilis)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
THR A 185
None
0.92A 2f94F-4kkmA:
26.3
2f94F-4kkmA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE


(Streptococcus
uberis)
PF00348
(polyprenyl_synt)
7 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
1.07A 2f94F-4lfeA:
25.9
2f94F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE


(Streptococcus
uberis)
PF00348
(polyprenyl_synt)
8 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
0.88A 2f94F-4lfeA:
25.9
2f94F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE


(Roseobacter
denitrificans)
PF00348
(polyprenyl_synt)
10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
0.63A 2f94F-4llsA:
29.3
2f94F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  88
LYS A 174
THR A 175
GLN A 211
None
0.84A 2f94F-4lobA:
27.5
2f94F-4lobA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
5 LEU A  85
LYS A 174
THR A 175
GLN A 211
ASP A 214
None
0.86A 2f94F-4lobA:
27.5
2f94F-4lobA:
28.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.56A 2f94F-4p0vA:
55.2
2f94F-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.27A 2f94F-4p0vA:
55.2
2f94F-4p0vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
11 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
0.66A 2f94F-4rxeA:
43.3
2f94F-4rxeA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
11 LEU A 100
ASP A 103
ASP A 107
THR A 168
GLN A 172
LYS A 212
THR A 213
TYR A 216
GLN A 252
ASP A 255
LYS A 269
3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
None
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 (-4.7A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
0.85A 2f94F-4rxeA:
43.3
2f94F-4rxeA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE


(Thermotoga
neapolitana)
PF00348
(polyprenyl_synt)
6 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
None
0.77A 2f94F-4wk5A:
24.7
2f94F-4wk5A:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
12 LEU B 100
ASP B 103
ASP B 107
ARG B 112
THR B 168
GLN B 172
LYS B 212
THR B 213
TYR B 216
GLN B 252
ASP B 255
LYS B 269
None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
None
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
None
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
0.46A 2f94F-5ahuB:
17.0
2f94F-5ahuB:
33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE


(Geobacillus
stearothermophilus)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
THR A 184
None
0.90A 2f94F-5aypA:
24.2
2f94F-5aypA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE


(Geobacillus
stearothermophilus)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
LYS A 183
THR A 184
None
0.84A 2f94F-5aypA:
24.2
2f94F-5aypA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE


(Geobacillus
stearothermophilus)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
THR A 184
GLN A 160
None
1.46A 2f94F-5aypA:
24.2
2f94F-5aypA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL


(Arabidopsis
thaliana)
PF00348
(polyprenyl_synt)
5 LEU A  88
ASP A  97
ARG A 102
GLN A 163
THR A 191
None
0.94A 2f94F-5e8kA:
22.9
2f94F-5e8kA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00348
(polyprenyl_synt)
5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
THR A 193
None
0.93A 2f94F-5e8lA:
24.0
2f94F-5e8lA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE


(Diaporthe
amygdali)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  88
GLN A 150
THR A 176
GLN A 216
None
0.91A 2f94F-5ernA:
8.0
2f94F-5ernA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
6 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
0.94A 2f94F-5h9dA:
28.4
2f94F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
0.76A 2f94F-5h9dA:
28.4
2f94F-5h9dA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
PO4  A 501 (-4.5A)
None
None
None
None
0.94A 2f94F-5h9dA:
28.4
2f94F-5h9dA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE


(Plasmodium
vivax)
PF00348
(polyprenyl_synt)
11 ASP A 126
ASP A 130
ARG A 135
THR A 191
GLN A 195
LYS A 243
THR A 244
TYR A 247
GLN A 284
ASP A 287
LYS A 301
04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-4.8A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
04M  A 401 (-4.5A)
None
None
04M  A 401 ( 3.9A)
0.59A 2f94F-5hn7A:
43.9
2f94F-5hn7A:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfq GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Geoglobus
acetivorans)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  85
GLN A 148
THR A 173
GLN A 210
None
0.76A 2f94F-5jfqA:
26.0
2f94F-5jfqA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa)
PF00348
(polyprenyl_synt)
5 LEU A  82
ASP A  85
ASP A  91
THR A 191
GLN A 228
None
1.01A 2f94F-5xn6A:
24.1
2f94F-5xn6A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE


(Choristoneura
fumiferana)
no annotation 9 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
THR A 245
GLN A 284
ASP A 287
LYS A 301
MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
C6M  A 401 (-2.9A)
0.54A 2f94F-6b07A:
46.7
2f94F-6b07A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE


(Choristoneura
fumiferana)
no annotation 10 ASP A 147
ASP A 151
ARG A 156
THR A 211
LYS A 244
THR A 245
TYR A 248
GLN A 284
ASP A 287
LYS A 301
MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
None
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
None
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
C6M  A 401 (-2.9A)
0.30A 2f94F-6b07A:
46.7
2f94F-6b07A:
14.23