SIMILAR PATTERNS OF AMINO ACIDS FOR 2F94_F_BFQF9001_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 7 | LEU A 114ARG A 126THR A 181GLN A 185LYS A 214THR A 215TYR A 218 | None | 0.87A | 2f94F-1fpsA:44.5 | 2f94F-1fpsA:69.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 5 | LEU A 114ARG A 126THR A 215TYR A 218GLN A 254 | None | 0.81A | 2f94F-1fpsA:44.5 | 2f94F-1fpsA:69.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 7 | LEU A 114ASP A 117ARG A 126THR A 181GLN A 185THR A 215TYR A 218 | None | 0.77A | 2f94F-1fpsA:44.5 | 2f94F-1fpsA:69.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 5 | LEU A 114ASP A 117ASP A 121ARG A 126THR A 215 | None | 0.78A | 2f94F-1fpsA:44.5 | 2f94F-1fpsA:69.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 5 | LEU A 114ASP A 121ARG A 126LYS A 214THR A 215 | None | 0.96A | 2f94F-1fpsA:44.5 | 2f94F-1fpsA:69.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rqj | GERANYLTRANSTRANSFERASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 10 | LEU A 102ASP A 105ASP A 111ARG A 116GLN A 179LYS A 202THR A 203GLN A 241ASP A 244LYS A 258 | None MG A 907 (-2.5A) MG A 909 (-2.4A)RIS A 901 (-2.7A)RIS A 901 (-3.2A)RIS A 901 (-2.5A)IPE A 900 ( 3.3A)RIS A 901 ( 3.6A) MG A 908 ( 2.7A)RIS A 901 (-2.7A) | 0.68A | 2f94F-1rqjA:30.1 | 2f94F-1rqjA:27.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtr | GERANYLTRANSTRANSFERASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 6 | LEU A 79ASP A 88ARG A 93GLN A 154THR A 178GLN A 215 | None | 0.84A | 2f94F-1rtrA:25.6 | 2f94F-1rtrA:26.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmw | GERANYLGERANYLDIPHOSPHATESYNTHETASE (Thermusthermophilus) |
PF00348(polyprenyl_synt) | 6 | LEU A 76ARG A 88THR A 142TYR A 176GLN A 209ASP A 212 | None | 0.87A | 2f94F-1wmwA:32.4 | 2f94F-1wmwA:29.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmw | GERANYLGERANYLDIPHOSPHATESYNTHETASE (Thermusthermophilus) |
PF00348(polyprenyl_synt) | 7 | LEU A 76ASP A 79ASP A 83ARG A 88GLN A 146TYR A 176GLN A 209 | None | 0.96A | 2f94F-1wmwA:32.4 | 2f94F-1wmwA:29.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmw | GERANYLGERANYLDIPHOSPHATESYNTHETASE (Thermusthermophilus) |
PF00348(polyprenyl_synt) | 7 | LEU A 76ASP A 83ARG A 88THR A 142GLN A 146TYR A 176GLN A 209 | None | 0.54A | 2f94F-1wmwA:32.4 | 2f94F-1wmwA:29.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy0 | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Pyrococcushorikoshii) |
PF00348(polyprenyl_synt) | 6 | LEU A 83ASP A 90ARG A 95GLN A 153THR A 178GLN A 215 | None | 0.64A | 2f94F-1wy0A:28.8 | 2f94F-1wy0A:27.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 6 | ASP A 85ARG A 90LYS A 160THR A 161GLN A 197ASP A 200 | None | 1.40A | 2f94F-2azkA:23.6 | 2f94F-2azkA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 5 | LEU A 78ASP A 81ARG A 90THR A 161GLN A 197 | None | 1.02A | 2f94F-2azkA:23.6 | 2f94F-2azkA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 5 | LEU A 78ASP A 81THR A 139THR A 161GLN A 197 | None | 0.87A | 2f94F-2azkA:23.6 | 2f94F-2azkA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 6 | LEU A 78ASP A 85ARG A 90THR A 161GLN A 197ASP A 200 | None | 0.90A | 2f94F-2azkA:23.6 | 2f94F-2azkA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2azk | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Sulfolobussolfataricus) |
PF00348(polyprenyl_synt) | 5 | LEU A 78ASP A 85THR A 139THR A 161GLN A 197 | None | 0.64A | 2f94F-2azkA:23.6 | 2f94F-2azkA:25.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dh4 | YPL069C (Saccharomycescerevisiae) |
PF00348(polyprenyl_synt) | 9 | LEU A 77ASP A 80ASP A 84ARG A 89GLN A 147LYS A 174THR A 175GLN A 211ASP A 214 | None MG A 341 (-2.6A) MG A 341 (-3.0A) MG A 341 ( 4.6A)NoneNoneNoneNoneNone | 0.44A | 2f94F-2dh4A:14.1 | 2f94F-2dh4A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftz | GERANYLTRANSTRANSFERASE (Thermotogamaritima) |
PF00348(polyprenyl_synt) | 5 | LEU A 71ASP A 74ARG A 85THR A 164GLN A 198 | NoneUNL A 273 (-3.0A)UNL A 274 (-4.1A)MLY A 163 ( 3.9A)MLY A 163 ( 3.8A) | 0.81A | 2f94F-2ftzA:25.2 | 2f94F-2ftzA:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftz | GERANYLTRANSTRANSFERASE (Thermotogamaritima) |
PF00348(polyprenyl_synt) | 5 | LEU A 71ASP A 80ARG A 85THR A 164GLN A 198 | NoneMLY A 223 ( 3.6A)UNL A 274 (-4.1A)MLY A 163 ( 3.9A)MLY A 163 ( 3.8A) | 0.42A | 2f94F-2ftzA:25.2 | 2f94F-2ftzA:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1o | PUTATIVE FARNESYLPYROPHOSPHATESYNTHASE (Cryptosporidiumparvum) |
PF00348(polyprenyl_synt) | 8 | LEU A 112ASP A 115ASP A 119ARG A 124THR A 180GLN A 184LYS A 210GLN A 251 | None MG A 503 (-2.5A) MG A 502 (-2.4A)RIS A 400 (-2.9A)NoneRIS A 400 ( 3.5A)RIS A 400 (-2.8A)RIS A 400 (-3.1A) | 0.71A | 2f94F-2o1oA:36.0 | 2f94F-2o1oA:29.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1o | PUTATIVE FARNESYLPYROPHOSPHATESYNTHASE (Cryptosporidiumparvum) |
PF00348(polyprenyl_synt) | 9 | LEU A 112ASP A 115ASP A 119ARG A 124THR A 180LYS A 210THR A 211TYR A 214GLN A 251 | None MG A 503 (-2.5A) MG A 502 (-2.4A)RIS A 400 (-2.9A)NoneRIS A 400 (-2.8A)RIS A 400 (-3.7A)NoneRIS A 400 (-3.1A) | 0.41A | 2f94F-2o1oA:36.0 | 2f94F-2o1oA:29.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q80 | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 6 | LEU A 61ARG A 73LYS A 151GLN A 185ASP A 188LYS A 202 | NoneGRG A 500 (-2.9A)GRG A 500 (-2.8A)GRG A 500 (-3.2A)GRG A 500 (-3.5A)GRG A 500 ( 2.6A) | 1.33A | 2f94F-2q80A:16.2 | 2f94F-2q80A:26.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q80 | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 8 | LEU A 61ASP A 64ASP A 68ARG A 73GLN A 126LYS A 151GLN A 185ASP A 188 | NoneGRG A 500 (-2.4A) MG A 400 (-2.6A)GRG A 500 (-2.9A)GRG A 500 ( 3.5A)GRG A 500 (-2.8A)GRG A 500 (-3.2A)GRG A 500 (-3.5A) | 0.82A | 2f94F-2q80A:16.2 | 2f94F-2q80A:26.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q80 | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 7 | LEU A 61ASP A 64ASP A 68ARG A 73GLN A 126LYS A 151THR A 152 | NoneGRG A 500 (-2.4A) MG A 400 (-2.6A)GRG A 500 (-2.9A)GRG A 500 ( 3.5A)GRG A 500 (-2.8A)GRG A 500 ( 4.6A) | 0.89A | 2f94F-2q80A:16.2 | 2f94F-2q80A:26.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q80 | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 6 | LEU A 61ASP A 64ASP A 68ARG A 73THR A 152GLN A 126 | NoneGRG A 500 (-2.4A) MG A 400 (-2.6A)GRG A 500 (-2.9A)GRG A 500 ( 4.6A)GRG A 500 ( 3.5A) | 1.41A | 2f94F-2q80A:16.2 | 2f94F-2q80A:26.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq0 | GERANYL DIPHOSPHATESYNTHASE (Arabidopsisthaliana) |
PF00348(polyprenyl_synt) | 6 | LEU A 104ASP A 107ASP A 111ARG A 116LYS A 193THR A 194 | None MG A1000 (-2.9A) MG A1001 (-2.8A)FPP A1002 (-2.9A)FPP A1002 (-2.5A)ISY A1003 (-4.7A) | 0.61A | 2f94F-3aq0A:25.8 | 2f94F-3aq0A:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt) | 7 | ASP B 84ASP B 88ARG B 93LYS B 170THR B 171GLN B 208ASP B 211 | MG B 326 (-2.6A) MG B 327 (-2.4A)2DE B 329 (-3.8A)2DE B 329 (-2.5A)NoneNone MG B 328 (-3.1A) | 1.00A | 2f94F-3aqcB:28.3 | 2f94F-3aqcB:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt) | 7 | LEU B 81ASP B 84ASP B 88ARG B 93LYS B 170THR B 171GLN B 208 | None MG B 326 (-2.6A) MG B 327 (-2.4A)2DE B 329 (-3.8A)2DE B 329 (-2.5A)NoneNone | 0.78A | 2f94F-3aqcB:28.3 | 2f94F-3aqcB:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lom | GERANYLTRANSTRANSFERASE (Legionellapneumophila) |
PF00348(polyprenyl_synt) | 5 | LEU A 91ASP A 100ARG A 105GLN A 168THR A 193 | None | 0.79A | 2f94F-3lomA:25.8 | 2f94F-3lomA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lom | GERANYLTRANSTRANSFERASE (Legionellapneumophila) |
PF00348(polyprenyl_synt) | 5 | LEU A 91ASP A 100GLN A 168THR A 193GLN A 231 | None | 0.89A | 2f94F-3lomA:25.8 | 2f94F-3lomA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0g | FARNESYL DIPHOSPHATESYNTHASE (Rhodobactercapsulatus) |
PF00348(polyprenyl_synt) | 5 | LEU A 78ASP A 87ARG A 92GLN A 153THR A 179 | None | 0.48A | 2f94F-3m0gA:25.2 | 2f94F-3m0gA:27.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0g | FARNESYL DIPHOSPHATESYNTHASE (Rhodobactercapsulatus) |
PF00348(polyprenyl_synt) | 5 | LEU A 78ASP A 87ARG A 92LYS A 178THR A 179 | None | 0.64A | 2f94F-3m0gA:25.2 | 2f94F-3m0gA:27.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9u | FARNESYL-DIPHOSPHATESYNTHASE (Lactobacillusbrevis) |
PF00348(polyprenyl_synt) | 5 | LEU A 86ARG A 100THR A 184GLN A 221ASP A 224 | GOL A 310 ( 4.3A)NoneNoneNoneNone | 0.88A | 2f94F-3m9uA:25.7 | 2f94F-3m9uA:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mzv | DECAPRENYLDIPHOSPHATE SYNTHASE (Rhodobactercapsulatus) |
PF00348(polyprenyl_synt) | 6 | LEU A 90ASP A 93ARG A 102LYS A 179THR A 180GLN A 217 | None | 0.79A | 2f94F-3mzvA:26.4 | 2f94F-3mzvA:26.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nf2 | PUTATIVE POLYPRENYLSYNTHETASE (Streptomycescoelicolor) |
PF00348(polyprenyl_synt) | 5 | LEU A 125ASP A 132ARG A 137GLN A 193LYS A 217 | NoneSO4 A 3 (-4.2A)NoneSO4 A 3 ( 4.8A)SO4 A 3 (-2.8A) | 0.87A | 2f94F-3nf2A:26.7 | 2f94F-3nf2A:26.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npk | GERANYLTRANSTRANSFERASE (Campylobacterjejuni) |
PF00348(polyprenyl_synt) | 5 | LEU A 75ARG A 89GLN A 149THR A 173GLN A 210 | None | 0.82A | 2f94F-3npkA:26.2 | 2f94F-3npkA:27.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npk | GERANYLTRANSTRANSFERASE (Campylobacterjejuni) |
PF00348(polyprenyl_synt) | 5 | LEU A 75ASP A 78ARG A 89LYS A 172THR A 173 | None | 0.97A | 2f94F-3npkA:26.2 | 2f94F-3npkA:27.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npk | GERANYLTRANSTRANSFERASE (Campylobacterjejuni) |
PF00348(polyprenyl_synt) | 5 | LEU A 75ASP A 84ARG A 89GLN A 149THR A 173 | None | 0.49A | 2f94F-3npkA:26.2 | 2f94F-3npkA:27.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3npk | GERANYLTRANSTRANSFERASE (Campylobacterjejuni) |
PF00348(polyprenyl_synt) | 5 | LEU A 75ASP A 84ARG A 89LYS A 172THR A 173 | None | 0.71A | 2f94F-3npkA:26.2 | 2f94F-3npkA:27.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p41 | GERANYLTRANSTRANSFERASE (Pseudomonasprotegens) |
PF00348(polyprenyl_synt) | 6 | LEU A 80ARG A 94GLN A 157LYS A 180THR A 181GLN A 219 | NoneDMA A 300 (-2.9A)DMA A 300 (-3.6A)POP A 301 ( 2.4A)NonePOP A 301 ( 4.5A) | 1.07A | 2f94F-3p41A:24.0 | 2f94F-3p41A:27.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p41 | GERANYLTRANSTRANSFERASE (Pseudomonasprotegens) |
PF00348(polyprenyl_synt) | 7 | LEU A 80ASP A 83ASP A 89ARG A 94GLN A 157LYS A 180THR A 181 | None MG A 297 (-2.5A) MG A 297 (-2.5A)DMA A 300 (-2.9A)DMA A 300 (-3.6A)POP A 301 ( 2.4A)None | 0.75A | 2f94F-3p41A:24.0 | 2f94F-3p41A:27.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8l | GERANYLTRANSTRANSFERASE (Enterococcusfaecalis) |
PF00348(polyprenyl_synt) | 5 | LEU A 79ASP A 82ARG A 93GLN A 153THR A 177 | None | 1.02A | 2f94F-3p8lA:25.6 | 2f94F-3p8lA:26.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8l | GERANYLTRANSTRANSFERASE (Enterococcusfaecalis) |
PF00348(polyprenyl_synt) | 5 | LEU A 79ASP A 88ARG A 93GLN A 153THR A 177 | None | 0.49A | 2f94F-3p8lA:25.6 | 2f94F-3p8lA:26.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8l | GERANYLTRANSTRANSFERASE (Enterococcusfaecalis) |
PF00348(polyprenyl_synt) | 5 | LEU A 79ASP A 88GLN A 153THR A 177GLN A 214 | None | 0.91A | 2f94F-3p8lA:25.6 | 2f94F-3p8lA:26.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pko | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Lactobacillusbrevis) |
PF00348(polyprenyl_synt) | 5 | LEU A 84ASP A 87ARG A 96LYS A 174THR A 175 | NoneNoneCIT A 326 ( 4.8A)NoneNone | 0.86A | 2f94F-3pkoA:25.3 | 2f94F-3pkoA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pko | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Lactobacillusbrevis) |
PF00348(polyprenyl_synt) | 5 | LEU A 84ASP A 91ARG A 96LYS A 174THR A 175 | NoneNoneCIT A 326 ( 4.8A)NoneNone | 0.79A | 2f94F-3pkoA:25.3 | 2f94F-3pkoA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1o | GERANYLTRANSTRANSFERASE (ISPA) (Helicobacterpylori) |
PF00348(polyprenyl_synt) | 9 | LEU A 89ASP A 92ASP A 98ARG A 103LYS A 186THR A 187GLN A 225ASP A 228LYS A 242 | DMA A 501 ( 4.8A) MG A 400 ( 2.8A) MG A 400 ( 3.2A)DMA A 501 (-3.0A)DMA A 501 (-3.1A)DMA A 500 (-3.4A)DMA A 501 ( 3.8A)DMA A 501 ( 3.5A)DMA A 501 (-2.7A) | 0.48A | 2f94F-3q1oA:31.1 | 2f94F-3q1oA:26.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1o | GERANYLTRANSTRANSFERASE (ISPA) (Helicobacterpylori) |
PF00348(polyprenyl_synt) | 9 | LEU A 89ASP A 92ASP A 98GLN A 163LYS A 186THR A 187GLN A 225ASP A 228LYS A 242 | DMA A 501 ( 4.8A) MG A 400 ( 2.8A) MG A 400 ( 3.2A)DMA A 501 (-3.6A)DMA A 501 (-3.1A)DMA A 500 (-3.4A)DMA A 501 ( 3.8A)DMA A 501 ( 3.5A)DMA A 501 (-2.7A) | 0.67A | 2f94F-3q1oA:31.1 | 2f94F-3q1oA:26.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqv | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Corynebacteriumglutamicum) |
PF00348(polyprenyl_synt) | 7 | LEU A 105ARG A 117GLN A 191LYS A 215THR A 216GLN A 254LYS A 271 | NoneDMA A 384 (-3.0A)DMA A 384 (-3.9A)DMA A 384 (-3.0A)DMA A 383 ( 4.0A)DMA A 383 (-3.2A)DMA A 384 ( 2.8A) | 1.35A | 2f94F-3qqvA:33.8 | 2f94F-3qqvA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqv | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Corynebacteriumglutamicum) |
PF00348(polyprenyl_synt) | 7 | LEU A 105ASP A 108ARG A 117GLN A 191LYS A 215THR A 216GLN A 254 | None MG A 381 (-2.4A)DMA A 384 (-3.0A)DMA A 384 (-3.9A)DMA A 384 (-3.0A)DMA A 383 ( 4.0A)DMA A 383 (-3.2A) | 0.89A | 2f94F-3qqvA:33.8 | 2f94F-3qqvA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqv | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Corynebacteriumglutamicum) |
PF00348(polyprenyl_synt) | 7 | LEU A 105ASP A 108ASP A 112ARG A 117LYS A 215THR A 216GLN A 254 | None MG A 381 (-2.4A) MG A 381 (-2.8A)DMA A 384 (-3.0A)DMA A 384 (-3.0A)DMA A 383 ( 4.0A)DMA A 383 (-3.2A) | 0.47A | 2f94F-3qqvA:33.8 | 2f94F-3qqvA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqv | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Corynebacteriumglutamicum) |
PF00348(polyprenyl_synt) | 6 | LEU A 105ASP A 108ASP A 112ARG A 117LYS A 215TYR A 219 | None MG A 381 (-2.4A) MG A 381 (-2.8A)DMA A 384 (-3.0A)DMA A 384 (-3.0A)DMA A 384 ( 4.9A) | 0.70A | 2f94F-3qqvA:33.8 | 2f94F-3qqvA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tc1 | OCTAPRENYLPYROPHOSPHATESYNTHASE (Helicobacterpylori) |
PF00348(polyprenyl_synt) | 5 | LEU A 74ASP A 77LYS A 162THR A 163GLN A 197 | None | 0.73A | 2f94F-3tc1A:25.9 | 2f94F-3tc1A:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tc1 | OCTAPRENYLPYROPHOSPHATESYNTHASE (Helicobacterpylori) |
PF00348(polyprenyl_synt) | 5 | LEU A 74LYS A 162THR A 163GLN A 197ASP A 200 | NoneNoneNoneNone MG A 500 (-2.9A) | 0.51A | 2f94F-3tc1A:25.9 | 2f94F-3tc1A:24.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ts7 | GERANYLTRANSTRANSFERASE (Methylococcuscapsulatus) |
PF00348(polyprenyl_synt) | 5 | LEU A 85ASP A 88ARG A 99LYS A 185THR A 186 | None | 0.98A | 2f94F-3ts7A:24.6 | 2f94F-3ts7A:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ts7 | GERANYLTRANSTRANSFERASE (Methylococcuscapsulatus) |
PF00348(polyprenyl_synt) | 5 | LEU A 85ASP A 94ARG A 99GLN A 162THR A 186 | None | 0.60A | 2f94F-3ts7A:24.6 | 2f94F-3ts7A:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ts7 | GERANYLTRANSTRANSFERASE (Methylococcuscapsulatus) |
PF00348(polyprenyl_synt) | 5 | LEU A 85ASP A 94ARG A 99LYS A 185THR A 186 | None | 0.68A | 2f94F-3ts7A:24.6 | 2f94F-3ts7A:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uca | GERANYLTRANSTRANSFERASE (Clostridiumperfringens) |
PF00348(polyprenyl_synt) | 5 | LEU A 88ASP A 97ARG A 102GLN A 163THR A 188 | None | 0.49A | 2f94F-3ucaA:26.3 | 2f94F-3ucaA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 6 | LEU A 81ARG A 93LYS A 170THR A 171GLN A 208ASP A 211 | NoneIPE A 401 ( 4.2A)IPE A 401 ( 2.9A)IPE A 402 ( 3.8A)IPE A 402 (-3.6A)IPE A 402 ( 4.6A) | 0.92A | 2f94F-3wjoA:25.7 | 2f94F-3wjoA:25.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 6 | LEU A 81ASP A 84ARG A 93LYS A 170THR A 171GLN A 208 | NoneIPE A 401 (-2.6A)IPE A 401 ( 4.2A)IPE A 401 ( 2.9A)IPE A 402 ( 3.8A)IPE A 402 (-3.6A) | 0.83A | 2f94F-3wjoA:25.7 | 2f94F-3wjoA:25.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjo | OCTAPRENYLDIPHOSPHATE SYNTHASE (Escherichiacoli) |
PF00348(polyprenyl_synt) | 6 | LEU A 81ASP A 84ASP A 88ARG A 93LYS A 170THR A 171 | NoneIPE A 401 (-2.6A)IPE A 401 (-3.3A)IPE A 401 ( 4.2A)IPE A 401 ( 2.9A)IPE A 402 ( 3.8A) | 0.83A | 2f94F-3wjoA:25.7 | 2f94F-3wjoA:25.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zou | FARNESYLPYROPHOSPHATESYNTHASE (Pseudomonasaeruginosa) |
PF00348(polyprenyl_synt) | 7 | LEU A 80ASP A 83ASP A 89ARG A 94GLN A 157LYS A 180THR A 181 | None MG A1295 (-2.5A) MG A1295 (-2.4A)GPP A1297 (-3.0A)GPP A1297 (-3.7A)GPP A1297 (-3.0A)None | 0.49A | 2f94F-3zouA:23.6 | 2f94F-3zouA:28.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e1e | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomacruzi) |
PF00348(polyprenyl_synt) | 12 | LEU A 95ASP A 98ASP A 102ARG A 107THR A 163GLN A 167LYS A 207THR A 208TYR A 211GLN A 247ASP A 250LYS A 264 | None MG A 403 (-2.5A) MG A 403 (-2.4A)0MW A 404 (-2.7A)None0MW A 404 (-3.7A)0MW A 404 (-2.8A)IPE A 405 ( 4.6A)None0MW A 404 ( 3.8A) MG A 401 (-2.7A)0MW A 404 ( 3.0A) | 0.42A | 2f94F-4e1eA:44.3 | 2f94F-4e1eA:37.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f62 | GERANYLTRANSTRANSFERASE (Marinomonas sp.MED121) |
PF00348(polyprenyl_synt) | 5 | LEU A 80ASP A 83ASP A 89LYS A 178THR A 179 | None | 0.73A | 2f94F-4f62A:24.1 | 2f94F-4f62A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fp4 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 6 | ASP A 86ASP A 90ARG A 95GLN A 147THR A 163GLN A 199 | UNX A 302 ( 2.6A)UNX A 302 ( 3.2A)UNX A 302 ( 4.6A)GER A 301 ( 4.7A)NoneNone | 0.89A | 2f94F-4fp4A:20.8 | 2f94F-4fp4A:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fp4 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 6 | ASP A 86ASP A 90ARG A 95LYS A 162THR A 163GLN A 199 | UNX A 302 ( 2.6A)UNX A 302 ( 3.2A)UNX A 302 ( 4.6A)GER A 301 ( 4.8A)NoneNone | 1.13A | 2f94F-4fp4A:20.8 | 2f94F-4fp4A:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fp4 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 6 | LEU A 83ASP A 86ASP A 90ARG A 95LYS A 162THR A 163 | UNL A 303 ( 4.7A)UNX A 302 ( 2.6A)UNX A 302 ( 3.2A)UNX A 302 ( 4.6A)GER A 301 ( 4.8A)None | 1.00A | 2f94F-4fp4A:20.8 | 2f94F-4fp4A:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 6 | LEU A 82ASP A 85ASP A 89ARG A 94LYS A 184THR A 185 | None | 0.86A | 2f94F-4gp1A:28.2 | 2f94F-4gp1A:26.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxy | TRANS-HEXAPRENYLTRANSTRANSFERASE (Pseudoalteromonasatlantica) |
PF00348(polyprenyl_synt) | 5 | LEU A 81ASP A 84LYS A 170THR A 171GLN A 208 | None | 0.92A | 2f94F-4jxyA:25.6 | 2f94F-4jxyA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxy | TRANS-HEXAPRENYLTRANSTRANSFERASE (Pseudoalteromonasatlantica) |
PF00348(polyprenyl_synt) | 5 | LEU A 81LYS A 170THR A 171GLN A 208ASP A 211 | None | 0.91A | 2f94F-4jxyA:25.6 | 2f94F-4jxyA:24.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4jzx | FARNESYLPYROPHOSPHATESYNTHASE (Leishmaniamajor) |
PF00348(polyprenyl_synt) | 12 | LEU A 95ASP A 98ASP A 102ARG A 107THR A 163GLN A 167LYS A 207THR A 208TYR A 211GLN A 247ASP A 250LYS A 264 | None CA A 403 (-2.5A) CA A 403 (-2.5A)476 A 402 (-2.9A)476 A 402 (-4.8A)476 A 402 (-3.5A)476 A 402 (-2.7A)IPE A 401 ( 3.4A)NoneIPE A 401 (-3.7A) CA A 404 (-3.0A)476 A 402 (-2.9A) | 0.37A | 2f94F-4jzxA:44.8 | 2f94F-4jzxA:38.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4kk2 | MONOTERPENE SYNTHASEFDS-5, CHLOROPLASTIC- FARNESYLDIPHOSPHATE SYNTHASE1 CHIMERA (Artemisiaspiciformis) |
PF00348(polyprenyl_synt) | 7 | LEU A 94ASP A 97ARG A 106THR A 161GLN A 165THR A 195TYR A 198 | None | 0.62A | 2f94F-4kk2A:40.5 | 2f94F-4kk2A:44.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4kk2 | MONOTERPENE SYNTHASEFDS-5, CHLOROPLASTIC- FARNESYLDIPHOSPHATE SYNTHASE1 CHIMERA (Artemisiaspiciformis) |
PF00348(polyprenyl_synt) | 7 | LEU A 94ASP A 97ARG A 106THR A 161LYS A 194THR A 195TYR A 198 | None | 0.81A | 2f94F-4kk2A:40.5 | 2f94F-4kk2A:44.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4kk2 | MONOTERPENE SYNTHASEFDS-5, CHLOROPLASTIC- FARNESYLDIPHOSPHATE SYNTHASE1 CHIMERA (Artemisiaspiciformis) |
PF00348(polyprenyl_synt) | 6 | LEU A 94THR A 161GLN A 165THR A 195TYR A 198GLN A 233 | None | 0.79A | 2f94F-4kk2A:40.5 | 2f94F-4kk2A:44.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kkm | POLYPRENYLSYNTHETASE (Zymomonasmobilis) |
PF00348(polyprenyl_synt) | 6 | LEU A 83ASP A 86ASP A 92ARG A 97GLN A 159THR A 185 | None | 0.92A | 2f94F-4kkmA:26.3 | 2f94F-4kkmA:27.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfe | GERANYLGERANYLDIPHOSPHATE SYNTHASE (Streptococcusuberis) |
PF00348(polyprenyl_synt) | 7 | LEU A 75ARG A 89GLN A 149LYS A 172THR A 173GLN A 210ASP A 213 | IPE A 301 (-4.7A)IPE A 301 (-2.8A)IPE A 301 ( 3.7A)IPE A 301 (-3.0A)NoneNoneNone | 1.07A | 2f94F-4lfeA:25.9 | 2f94F-4lfeA:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lfe | GERANYLGERANYLDIPHOSPHATE SYNTHASE (Streptococcusuberis) |
PF00348(polyprenyl_synt) | 8 | LEU A 75ASP A 78ASP A 84ARG A 89GLN A 149LYS A 172THR A 173GLN A 210 | IPE A 301 (-4.7A) MG A 302 (-2.5A) MG A 302 (-2.4A)IPE A 301 (-2.8A)IPE A 301 ( 3.7A)IPE A 301 (-3.0A)NoneNone | 0.88A | 2f94F-4lfeA:25.9 | 2f94F-4lfeA:26.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lls | GERANYLTRANSTRANSFERASE (Roseobacterdenitrificans) |
PF00348(polyprenyl_synt) | 10 | LEU A 77ASP A 80ASP A 86ARG A 91GLN A 153LYS A 178THR A 179GLN A 213ASP A 216LYS A 230 | None CA A 304 ( 2.9A) CA A 305 (-2.3A)GST A 302 (-2.9A)GST A 302 (-3.7A)GST A 302 (-3.4A)IPE A 301 (-4.2A)IPE A 301 ( 4.1A) CA A 303 (-2.9A)GST A 302 (-2.7A) | 0.63A | 2f94F-4llsA:29.3 | 2f94F-4llsA:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lob | POLYPRENYLSYNTHETASE (Acinetobacterbaumannii) |
PF00348(polyprenyl_synt) | 5 | LEU A 85ASP A 88LYS A 174THR A 175GLN A 211 | None | 0.84A | 2f94F-4lobA:27.5 | 2f94F-4lobA:28.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lob | POLYPRENYLSYNTHETASE (Acinetobacterbaumannii) |
PF00348(polyprenyl_synt) | 5 | LEU A 85LYS A 174THR A 175GLN A 211ASP A 214 | None | 0.86A | 2f94F-4lobA:27.5 | 2f94F-4lobA:28.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p0v | FARNESYLPYROPHOSPHATESYNTHASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 11 | LEU A 100ASP A 103ASP A 107ARG A 112THR A 167GLN A 171LYS A 200THR A 201GLN A 240ASP A 243LYS A 257 | None MG A 405 (-2.5A) MG A 405 (-2.4A)ZOL A 401 ( 2.7A)NoneZOL A 401 ( 3.8A)ZOL A 401 (-2.7A)ZOL A 401 (-3.7A)ZOL A 401 (-3.5A) MG A 404 (-2.8A)1WO A 402 ( 2.8A) | 0.56A | 2f94F-4p0vA:55.2 | 2f94F-4p0vA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p0v | FARNESYLPYROPHOSPHATESYNTHASE (Homo sapiens) |
PF00348(polyprenyl_synt) | 11 | LEU A 100ASP A 103ASP A 107ARG A 112THR A 167LYS A 200THR A 201TYR A 204GLN A 240ASP A 243LYS A 257 | None MG A 405 (-2.5A) MG A 405 (-2.4A)ZOL A 401 ( 2.7A)NoneZOL A 401 (-2.7A)ZOL A 401 (-3.7A)NoneZOL A 401 (-3.5A) MG A 404 (-2.8A)1WO A 402 ( 2.8A) | 0.27A | 2f94F-4p0vA:55.2 | 2f94F-4p0vA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rxe | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomabrucei) |
PF00348(polyprenyl_synt) | 11 | LEU A 100ASP A 103ASP A 107ARG A 112THR A 168GLN A 172LYS A 212THR A 213TYR A 216GLN A 252ASP A 255 | 3YQ A3001 ( 4.6A) MG A3004 (-2.5A) MG A3004 (-2.3A)3YQ A3001 (-2.8A)None MG A3004 ( 3.8A)3YQ A3001 (-2.9A)3YQ A3001 (-4.2A)3YQ A3001 (-4.7A)3YQ A3001 ( 4.2A) MG A3003 ( 2.9A) | 0.66A | 2f94F-4rxeA:43.3 | 2f94F-4rxeA:36.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rxe | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomabrucei) |
PF00348(polyprenyl_synt) | 11 | LEU A 100ASP A 103ASP A 107THR A 168GLN A 172LYS A 212THR A 213TYR A 216GLN A 252ASP A 255LYS A 269 | 3YQ A3001 ( 4.6A) MG A3004 (-2.5A) MG A3004 (-2.3A)None MG A3004 ( 3.8A)3YQ A3001 (-2.9A)3YQ A3001 (-4.2A)3YQ A3001 (-4.7A)3YQ A3001 ( 4.2A) MG A3003 ( 2.9A)3YQ A3001 (-3.1A) | 0.85A | 2f94F-4rxeA:43.3 | 2f94F-4rxeA:36.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wk5 | GERANYLTRANSTRANSFERASE (Thermotoganeapolitana) |
PF00348(polyprenyl_synt) | 6 | LEU A 71ASP A 80ARG A 85THR A 164GLN A 198ASP A 201 | None | 0.77A | 2f94F-4wk5A:24.7 | 2f94F-4wk5A:25.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ahu | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomabrucei) |
PF00348(polyprenyl_synt) | 12 | LEU B 100ASP B 103ASP B 107ARG B 112THR B 168GLN B 172LYS B 212THR B 213TYR B 216GLN B 252ASP B 255LYS B 269 | None MG B1370 (-2.5A) MG B1369 (-2.2A)G76 B1368 (-2.8A)NoneG76 B1368 ( 4.1A)G76 B1368 (-2.8A)G76 B1368 (-4.2A)NoneG76 B1368 ( 4.0A) MG B1371 ( 3.0A)G76 B1368 (-3.1A) | 0.46A | 2f94F-5ahuB:17.0 | 2f94F-5ahuB:33.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ayp | FARNESYL DIPHOSPHATESYNTHASE (Geobacillusstearothermophilus) |
PF00348(polyprenyl_synt) | 6 | LEU A 83ASP A 86ASP A 92ARG A 97GLN A 160THR A 184 | None | 0.90A | 2f94F-5aypA:24.2 | 2f94F-5aypA:26.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ayp | FARNESYL DIPHOSPHATESYNTHASE (Geobacillusstearothermophilus) |
PF00348(polyprenyl_synt) | 6 | LEU A 83ASP A 86ASP A 92ARG A 97LYS A 183THR A 184 | None | 0.84A | 2f94F-5aypA:24.2 | 2f94F-5aypA:26.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ayp | FARNESYL DIPHOSPHATESYNTHASE (Geobacillusstearothermophilus) |
PF00348(polyprenyl_synt) | 6 | LEU A 83ASP A 86ASP A 92ARG A 97THR A 184GLN A 160 | None | 1.46A | 2f94F-5aypA:24.2 | 2f94F-5aypA:26.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8k | GERANYLGERANYLPYROPHOSPHATESYNTHASE 10,MITOCHONDRIAL (Arabidopsisthaliana) |
PF00348(polyprenyl_synt) | 5 | LEU A 88ASP A 97ARG A 102GLN A 163THR A 191 | None | 0.94A | 2f94F-5e8kA:22.9 | 2f94F-5e8kA:26.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8l | HETERODIMERICGERANYLGERANYLPYROPHOSPHATESYNTHASE LARGESUBUNIT 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00348(polyprenyl_synt) | 5 | LEU A 88ASP A 91ASP A 97ARG A 102THR A 193 | None | 0.93A | 2f94F-5e8lA:24.0 | 2f94F-5e8lA:25.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ern | FUSICOCCADIENESYNTHASE (Diaportheamygdali) |
PF00348(polyprenyl_synt) | 5 | LEU A 85ASP A 88GLN A 150THR A 176GLN A 216 | None | 0.91A | 2f94F-5ernA:8.0 | 2f94F-5ernA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 6 | LEU A 79ASP A 82ARG A 91LYS A 168THR A 169GLN A 206 | PO4 A 501 (-4.5A)NonePO4 A 501 ( 4.9A)NoneNoneNone | 0.94A | 2f94F-5h9dA:28.4 | 2f94F-5h9dA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 5 | LEU A 79ASP A 86ARG A 91LYS A 168THR A 169 | PO4 A 501 (-4.5A)NonePO4 A 501 ( 4.9A)NoneNone | 0.76A | 2f94F-5h9dA:28.4 | 2f94F-5h9dA:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9d | FARNESYLPYROPHOSPHATESYNTHETASE (Staphylococcusaureus) |
PF00348(polyprenyl_synt) | 5 | LEU A 79LYS A 168THR A 169GLN A 206ASP A 209 | PO4 A 501 (-4.5A)NoneNoneNoneNone | 0.94A | 2f94F-5h9dA:28.4 | 2f94F-5h9dA:23.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hn7 | FARNESYLPYROPHOSPHATESYNTHASE, PUTATIVE (Plasmodiumvivax) |
PF00348(polyprenyl_synt) | 11 | ASP A 126ASP A 130ARG A 135THR A 191GLN A 195LYS A 243THR A 244TYR A 247GLN A 284ASP A 287LYS A 301 | 04M A 401 ( 4.0A)None04M A 401 (-3.5A)04M A 401 (-4.8A)04M A 401 (-3.3A)04M A 401 (-4.5A)04M A 401 ( 3.8A)04M A 401 (-4.5A)NoneNone04M A 401 ( 3.9A) | 0.59A | 2f94F-5hn7A:43.9 | 2f94F-5hn7A:34.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfq | GERANYLGERANYLPYROPHOSPHATESYNTHETASE (Geoglobusacetivorans) |
PF00348(polyprenyl_synt) | 5 | LEU A 78ASP A 85GLN A 148THR A 173GLN A 210 | None | 0.76A | 2f94F-5jfqA:26.0 | 2f94F-5jfqA:26.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xn6 | OS07G0580900 PROTEIN (Oryza sativa) |
PF00348(polyprenyl_synt) | 5 | LEU A 82ASP A 85ASP A 91THR A 191GLN A 228 | None | 1.01A | 2f94F-5xn6A:24.1 | 2f94F-5xn6A:26.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b07 | FARNESYL DIPHOSPHATESYNTHASE (Choristoneurafumiferana) |
no annotation | 9 | ASP A 147ASP A 151ARG A 156GLN A 215LYS A 244THR A 245GLN A 284ASP A 287LYS A 301 | MG A 402 (-2.6A) MG A 402 (-2.5A)C6M A 401 (-2.7A)C6M A 401 (-3.3A)C6M A 401 (-2.6A)C6M A 401 (-3.6A)C6M A 401 (-3.7A) MG A 404 ( 2.7A)C6M A 401 (-2.9A) | 0.54A | 2f94F-6b07A:46.7 | 2f94F-6b07A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b07 | FARNESYL DIPHOSPHATESYNTHASE (Choristoneurafumiferana) |
no annotation | 10 | ASP A 147ASP A 151ARG A 156THR A 211LYS A 244THR A 245TYR A 248GLN A 284ASP A 287LYS A 301 | MG A 402 (-2.6A) MG A 402 (-2.5A)C6M A 401 (-2.7A)NoneC6M A 401 (-2.6A)C6M A 401 (-3.6A)NoneC6M A 401 (-3.7A) MG A 404 ( 2.7A)C6M A 401 (-2.9A) | 0.30A | 2f94F-6b07A:46.7 | 2f94F-6b07A:14.23 |