SIMILAR PATTERNS OF AMINO ACIDS FOR 2F8L_A_SAMA400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 THR A 163
THR A 188
ASP A 186
ASP A 363
 SF4  A 582 (-4.1A)
None
None
None
 1.35A 2f8lA-1fehA:
undetectable		 2f8lA-1fehA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 THR A 257
THR A 262
ASP A 220
ASP A 172
 None
 1.50A 2f8lA-1itxA:
undetectable		 2f8lA-1itxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 THR A 414
THR A 363
ASP A 542
ASP A 535
 None
 1.34A 2f8lA-1j2bA:
undetectable		 2f8lA-1j2bA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		4 THR A  17
THR A  44
ASP A  62
ASP A  90
 SAH  A 801 (-3.7A)
SAH  A 801 (-4.1A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.76A 2f8lA-1l3iA:
14.2		 2f8lA-1l3iA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		4 THR A 513
THR A 400
ASP A 427
ASP A 488
 None
 1.40A 2f8lA-1on9A:
undetectable		 2f8lA-1on9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 THR A 307
THR A 160
ASP A 191
ASP A 118
 None
None
PLP  A 510 (-2.7A)
None
 1.44A 2f8lA-1v2dA:
undetectable		 2f8lA-1v2dA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		4 THR A 111
THR A 105
ASP A  83
ASP A  80
 None
 1.45A 2f8lA-1v6mA:
undetectable		 2f8lA-1v6mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 THR X 130
THR X  37
ASP X 107
ASP X  85
 None
 1.43A 2f8lA-1w52X:
undetectable		 2f8lA-1w52X:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		4 THR A  47
THR A  71
ASP A  62
ASP A  88
 None
None
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
 1.16A 2f8lA-1yb1A:
2.9		 2f8lA-1yb1A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysh RIBOSOMAL PROTEIN
L30

(Triticum
aestivum) 		PF01248
(Ribosomal_L7Ae) 		4 THR C 104
THR C 102
ASP C  98
ASP C  96
 None
 1.29A 2f8lA-1yshC:
undetectable		 2f8lA-1yshC:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 THR A 214
THR A 210
ASP A 230
ASP A 250
 None
None
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
 1.32A 2f8lA-1zgjA:
10.6		 2f8lA-1zgjA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		4 THR A  98
THR A 129
ASP A 154
ASP A 180
 SAM  A 400 (-3.8A)
SAM  A 400 (-2.9A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
 0.03A 2f8lA-2f8lA:
56.4		 2f8lA-2f8lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 THR A 154
THR A 181
ASP A 214
ASP A 243
 SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
 0.41A 2f8lA-2okcA:
6.8		 2f8lA-2okcA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 THR A 128
THR A  35
ASP A 105
ASP A  83
 None
 1.44A 2f8lA-2pvsA:
2.6		 2f8lA-2pvsA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		4 THR A 197
THR A 137
ASP A  70
ASP A  65
 None
 1.36A 2f8lA-2va1A:
undetectable		 2f8lA-2va1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		4 THR A  54
THR A  81
ASP A 102
ASP A 130
 SAH  A 464 (-3.5A)
None
SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
 0.99A 2f8lA-3c3yA:
14.8		 2f8lA-3c3yA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 THR A 277
THR A 272
ASP A  80
ASP A  87
 None
None
MG  A   1 ( 3.9A)
None
 1.50A 2f8lA-3gybA:
3.3		 2f8lA-3gybA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 THR A  28
THR A 273
ASP A 120
ASP A 118
 None
 1.45A 2f8lA-3h04A:
undetectable		 2f8lA-3h04A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4v INTEGRIN BETA-7

(Homo sapiens) 		PF00362
(Integrin_beta) 		4 THR B 188
THR B 181
ASP B 179
ASP B 271
 None
None
CA  B2003 (-3.8A)
None
 1.41A 2f8lA-3v4vB:
undetectable		 2f8lA-3v4vB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  19
THR H  70
ASP H  72
ASP H  27
 None
 1.50A 2f8lA-4lsqH:
undetectable		 2f8lA-4lsqH:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 THR A  30
THR A  48
ASP A 315
ASP A 320
 None
 1.33A 2f8lA-4mm0A:
undetectable		 2f8lA-4mm0A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 THR A 205
THR A 151
ASP A 775
ASP A  57
 None
 1.46A 2f8lA-4nmeA:
undetectable		 2f8lA-4nmeA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		4 THR A 303
THR A 257
ASP A 259
ASP A 239
 None
 1.50A 2f8lA-4u06A:
undetectable		 2f8lA-4u06A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		4 THR A  93
THR A  89
ASP A 113
ASP A 141
 None
None
SAH  A 801 (-3.0A)
SAH  A 801 (-3.7A)
 1.29A 2f8lA-4uy6A:
11.2		 2f8lA-4uy6A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 THR A 371
THR A 354
ASP A 352
ASP A1390
 None
 1.43A 2f8lA-4yknA:
undetectable		 2f8lA-4yknA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263

(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab) 		4 THR B 229
THR B 295
ASP B 293
ASP A 385
 None
 1.21A 2f8lA-5bn4B:
3.5		 2f8lA-5bn4B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis) 		PF00905
(Transpeptidase) 		4 THR A 215
THR A 217
ASP A 246
ASP A  45
 EDO  A 303 (-3.7A)
EDO  A 303 (-3.8A)
None
None
 1.50A 2f8lA-5e2fA:
undetectable		 2f8lA-5e2fA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 THR A 434
THR A 415
ASP A 420
ASP A  56
 None
 1.08A 2f8lA-5favA:
undetectable		 2f8lA-5favA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 THR A 166
THR A 262
ASP A  95
ASP A 105
 None
SO4  A1357 (-3.5A)
SO4  A1357 ( 4.8A)
None
 1.04A 2f8lA-5fyqA:
undetectable		 2f8lA-5fyqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 THR B 212
THR B 208
ASP B 230
ASP B 255
 None
None
SAH  B 501 (-2.7A)
SAH  B 501 (-3.9A)
 1.44A 2f8lA-5thzB:
12.0		 2f8lA-5thzB:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 THR A  75
THR A  80
ASP A  85
ASP A  91
 None
 1.41A 2f8lA-5ui2A:
undetectable		 2f8lA-5ui2A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 THR A1489
THR A1482
ASP A1453
ASP A1375
 None
 1.40A 2f8lA-5ujaA:
undetectable		 2f8lA-5ujaA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 4 THR A  27
THR A  57
ASP A  82
ASP A 109
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
 0.97A 2f8lA-5w7kA:
13.6		 2f8lA-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 4 THR A  27
THR A  57
ASP A  82
ASP A 109
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.8A)
 0.90A 2f8lA-5w7mA:
13.7		 2f8lA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 THR A 472
THR A 448
ASP A 432
ASP A 435
 None
 1.44A 2f8lA-5x7sA:
2.7		 2f8lA-5x7sA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 THR A1489
THR A1482
ASP A1453
ASP A1375
 None
None
MG  A1604 ( 4.1A)
None
 1.30A 2f8lA-6bhuA:
undetectable		 2f8lA-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 THR B 430
THR B 124
ASP B 890
ASP B 892
 None
 1.30A 2f8lA-6f42B:
undetectable		 2f8lA-6f42B:
undetectable