SIMILAR PATTERNS OF AMINO ACIDS FOR 2F8L_A_SAMA400_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		5 GLY A 174
ASP A 172
ASP A  14
PRO A  13
PHE A 128
 None
 1.03A 2f8lA-1f1uA:
undetectable		 2f8lA-1f1uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		5 GLY A 174
ASP A 172
ASP A  14
PRO A  13
PHE A 128
 None
 1.08A 2f8lA-1f1xA:
undetectable		 2f8lA-1f1xA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 GLY A  61
LEU A  65
VAL A  85
ASP A 175
PRO A 177
 None
 0.84A 2f8lA-1o9gA:
13.3		 2f8lA-1o9gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ALA A 636
GLY A 470
LEU A 472
VAL A 653
GLY A 651
 None
None
None
GOL  A 701 (-4.9A)
None
 1.12A 2f8lA-1q3xA:
undetectable		 2f8lA-1q3xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF00115
(COX1)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 ASN B 223
GLY A 470
ASP A 477
PRO A 479
PHE A 482
 None
 1.15A 2f8lA-1qleB:
undetectable		 2f8lA-1qleB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 HIS A 422
GLY A 125
ASN A 417
LEU A 416
LEU A 126
PHE A 393
 None
 1.02A 2f8lA-1r9jA:
3.6		 2f8lA-1r9jA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		5 ALA A  31
ASN A 280
VAL A  90
LEU A 113
ASP A  86
 None
 1.04A 2f8lA-1tjyA:
3.8		 2f8lA-1tjyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uer SUPEROXIDE DISMUTASE

(Porphyromonas
gingivalis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 155
LEU A 153
VAL A 158
ASP A 157
GLY A 115
 None
None
None
FE  A 192 (-2.6A)
None
 1.14A 2f8lA-1uerA:
undetectable		 2f8lA-1uerA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 ALA A  54
GLY A  58
ASN A  85
LEU A  61
PRO A 139
 None
 0.90A 2f8lA-1wekA:
2.7		 2f8lA-1wekA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		6 GLY A  59
LEU A  63
VAL A  80
ASP A  81
PRO A 121
PHE A 133
 SAH  A1001 (-3.3A)
SAH  A1001 ( 4.3A)
SAH  A1001 (-4.0A)
None
None
SAH  A1001 (-4.7A)
 0.91A 2f8lA-1wy7A:
17.2		 2f8lA-1wy7A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ALA A 636
GLY A 470
LEU A 472
VAL A 653
GLY A 651
 None
 1.15A 2f8lA-1zjkA:
undetectable		 2f8lA-1zjkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		5 ALA A 227
GLY A 229
ASP A 231
GLY A 247
PHE A 225
 None
 0.97A 2f8lA-2akoA:
2.7		 2f8lA-2akoA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmx ALKYL
HYDROPEROXIDASE C

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 ALA A 121
GLY A 123
ASN A 126
LEU A 125
LEU A   3
 None
 1.11A 2f8lA-2bmxA:
undetectable		 2f8lA-2bmxA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di9 FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		5 GLY A  84
ASP A  80
GLY A  62
ASP A  55
PHE A 104
 None
 1.03A 2f8lA-2di9A:
undetectable		 2f8lA-2di9A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ALA A 245
GLY A 243
ASP A  88
LEU A 242
GLY A 247
 None
 1.07A 2f8lA-2dsjA:
undetectable		 2f8lA-2dsjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 HIS A 419
GLY A 129
ASN A 414
LEU A 413
LEU A 130
 None
 1.00A 2f8lA-2e6kA:
2.8		 2f8lA-2e6kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 HIS A 419
GLY A 129
ASN A 414
LEU A 413
PHE A 390
 None
 0.98A 2f8lA-2e6kA:
2.8		 2f8lA-2e6kA:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		12 HIS A  95
ALA A 126
GLY A 128
ASN A 131
LEU A 132
VAL A 155
ASP A 156
LEU A 159
GLY A 181
ASP A 196
PRO A 198
PHE A 226
 SAM  A 400 (-4.5A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
None
SAM  A 400 (-4.1A)
SAM  A 400 (-4.2A)
None
SAM  A 400 (-4.3A)
SAM  A 400 (-3.6A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
 0.04A 2f8lA-2f8lA:
56.4		 2f8lA-2f8lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		8 HIS A  95
ALA A 126
GLY A 128
LEU A 133
VAL A 155
ASP A 156
LEU A 159
PHE A 226
 SAM  A 400 (-4.5A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
None
SAM  A 400 (-4.2A)
None
SAM  A 400 (-4.3A)
SAM  A 400 (-4.9A)
 1.43A 2f8lA-2f8lA:
56.4		 2f8lA-2f8lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		5 GLY A  62
LEU A  66
ASP A  84
ASP A 127
PRO A 129
 None
 1.11A 2f8lA-2fpoA:
14.4		 2f8lA-2fpoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go2 KUNITZ-TYPE SERINE
PROTEASE INHIBITOR
BBKI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		5 HIS A  51
GLY A  30
VAL A  46
ASP A  48
PHE A  78
 None
 1.06A 2f8lA-2go2A:
undetectable		 2f8lA-2go2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		5 HIS A  50
GLY A  29
VAL A  45
ASP A  47
PHE A  77
 None
 0.99A 2f8lA-2gzbA:
undetectable		 2f8lA-2gzbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		5 GLY A  75
VAL A  97
ASP A  98
PRO A 149
PHE A 190
 SAH  A 300 (-3.6A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-4.0A)
SAH  A 300 (-4.9A)
 1.00A 2f8lA-2h00A:
12.9		 2f8lA-2h00A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 ALA A  95
LEU A  90
ASP A 132
GLY A  99
ASP A  91
 None
 1.15A 2f8lA-2hz7A:
undetectable		 2f8lA-2hz7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 306
GLY A 309
VAL A 312
ASP A 311
GLY A 302
 GOL  A1103 ( 4.0A)
None
None
None
GOL  A1103 (-4.4A)
 1.06A 2f8lA-2nqlA:
undetectable		 2f8lA-2nqlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		5 ALA A 365
LEU A 404
VAL A 491
PRO A 443
PHE A 408
 None
 0.96A 2f8lA-2nvoA:
undetectable		 2f8lA-2nvoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B 604
VAL B 675
LEU B 681
GLY B 649
PHE B 532
 None
 1.12A 2f8lA-2rhqB:
undetectable		 2f8lA-2rhqB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1k PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		5 ALA A 113
LEU A 122
VAL A  83
LEU A 111
GLY A  80
 None
 1.12A 2f8lA-2w1kA:
undetectable		 2f8lA-2w1kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 GLY A  67
ASN A  88
LEU A  89
ASP A 390
LEU A  68
 None
 0.95A 2f8lA-2w8sA:
undetectable		 2f8lA-2w8sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 ALA A 363
GLY A 367
LEU A 178
LEU A 370
PRO A 339
 None
 1.15A 2f8lA-2ychA:
2.0		 2f8lA-2ychA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 267
VAL A 292
ASP A 293
ASP A 337
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.86A 2f8lA-2yxlA:
12.7		 2f8lA-2yxlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 270
LEU A  86
VAL A 275
LEU A 273
GLY A 243
 None
 1.03A 2f8lA-2zc8A:
undetectable		 2f8lA-2zc8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 ASN A 193
LEU A 192
VAL A  61
LEU A 129
GLY A  90
 None
 1.14A 2f8lA-3e57A:
undetectable		 2f8lA-3e57A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		5 GLY A 174
ASP A 172
ASP A  14
PRO A  13
PHE A 128
 None
 1.06A 2f8lA-3eckA:
undetectable		 2f8lA-3eckA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		5 GLY A  90
VAL A 112
ASP A 113
PRO A 157
PHE A 182
 None
 1.04A 2f8lA-3evzA:
14.8		 2f8lA-3evzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		5 ALA A 313
GLY A 292
ASN A 317
VAL A 223
GLY A 289
 None
 1.05A 2f8lA-3hlkA:
undetectable		 2f8lA-3hlkA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 ALA A  97
LEU A 693
VAL A  36
ASP A  38
GLY A  75
 None
 1.14A 2f8lA-3i5gA:
undetectable		 2f8lA-3i5gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6y ESTERASE APC40077

(Oleispira
antarctica) 		PF00756
(Esterase) 		5 ALA A  92
GLY A 100
ASP A  94
LEU A  99
PRO A 113
 None
 1.09A 2f8lA-3i6yA:
undetectable		 2f8lA-3i6yA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig2 PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Bacteroides
fragilis) 		no annotation 5 HIS A 614
ALA A 705
GLY A 616
LEU A 565
GLY A 686
 None
 1.10A 2f8lA-3ig2A:
undetectable		 2f8lA-3ig2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 5 GLY A 111
VAL A 208
LEU A 112
GLY A 234
ASP A 218
 None
 1.11A 2f8lA-3ixlA:
2.5		 2f8lA-3ixlA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 328
GLY A 304
VAL A 280
LEU A 278
GLY A 307
 None
AZI  A 385 (-3.0A)
None
GOL  A 381 ( 4.9A)
None
 1.08A 2f8lA-3jtmA:
7.0		 2f8lA-3jtmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4i HEAT SHOCK 70
(HSP70) PROTEIN

(Cryptosporidium
parvum) 		PF00012
(HSP70) 		5 ALA A 387
VAL A  35
ASP A  42
GLY A  23
ASP A 383
 None
 1.00A 2f8lA-3l4iA:
undetectable		 2f8lA-3l4iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		5 GLY A 103
LEU A 109
VAL A  63
LEU A 102
GLY A  65
 None
 1.15A 2f8lA-3lp5A:
undetectable		 2f8lA-3lp5A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 HIS A 340
ALA A 208
GLY A 228
ASN A 212
LEU A 211
 None
 1.10A 2f8lA-3o04A:
undetectable		 2f8lA-3o04A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 HIS A  48
ALA A  51
VAL A  40
GLY A  38
PRO A 307
 None
 1.15A 2f8lA-3oftA:
undetectable		 2f8lA-3oftA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		5 GLY A  53
LEU A  57
ASP A  75
ASP A 119
PRO A 121
 None
 1.14A 2f8lA-3p9nA:
14.5		 2f8lA-3p9nA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		6 ALA A 329
GLY A 331
ASN A 334
LEU A 335
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
EDO  A 906 ( 3.7A)
IOD  A 938 (-4.1A)
SAH  A 900 (-4.0A)
None
 0.82A 2f8lA-3s1sA:
0.0		 2f8lA-3s1sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 HIS A 293
ALA A 329
GLY A 331
ASN A 334
LEU A 335
 None
SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
EDO  A 906 ( 3.7A)
IOD  A 938 (-4.1A)
 0.95A 2f8lA-3s1sA:
0.0		 2f8lA-3s1sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLY A 484
ASN A 493
LEU A 492
GLY A 476
ASP A 487
 None
 1.11A 2f8lA-3s4dA:
undetectable		 2f8lA-3s4dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		5 ALA A  96
GLY A 100
VAL A  78
ASP A 102
GLY A  80
 None
 1.10A 2f8lA-3si9A:
undetectable		 2f8lA-3si9A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 HIS A 298
ALA A 258
LEU A 261
GLY A 226
PHE A  48
 None
 1.08A 2f8lA-3tqoA:
2.1		 2f8lA-3tqoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v34 RIBONUCLEASE ZC3H12A

(Homo sapiens) 		PF11977
(RNase_Zc3h12a) 		5 ALA A 146
ASN A 271
LEU A 162
GLY A 142
PHE A 155
 None
 1.12A 2f8lA-3v34A:
undetectable		 2f8lA-3v34A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		5 ASN A 321
ASP A 404
GLY A 399
ASP A  19
PRO A  31
 SO4  A 424 (-4.6A)
None
None
None
None
 1.13A 2f8lA-3va8A:
undetectable		 2f8lA-3va8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		5 ASN A 323
ASP A 404
GLY A 399
ASP A  20
PRO A  32
 FMT  A 501 (-4.0A)
None
None
None
None
 1.12A 2f8lA-3vdgA:
undetectable		 2f8lA-3vdgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 GLY A 675
LEU A 827
LEU A 674
PRO A 668
PHE A 573
 None
 1.00A 2f8lA-3w9iA:
2.8		 2f8lA-3w9iA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 GLY A 211
ASN A 241
LEU A 242
LEU A 210
GLY A 587
 None
 1.04A 2f8lA-3welA:
undetectable		 2f8lA-3welA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 GLY A 564
ASN A 641
ASP A 566
GLY A 541
PHE A 539
 None
 1.07A 2f8lA-3wfzA:
undetectable		 2f8lA-3wfzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnp CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Bacillus
circulans) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ALA A 364
GLY A 362
VAL A 356
ASP A 357
PHE A 330
 None
 1.05A 2f8lA-3wnpA:
undetectable		 2f8lA-3wnpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woh SIAM

(Streptomyces
sp. A7248) 		PF13561
(adh_short_C2) 		5 GLY A 223
LEU A 228
ASP A 219
GLY A  22
PRO A 189
 None
 1.13A 2f8lA-3wohA:
6.4		 2f8lA-3wohA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 318
ASP A 400
GLY A 395
ASP A  15
PRO A  27
 PO4  A 501 ( 4.8A)
None
None
None
None
 1.15A 2f8lA-4dhgA:
undetectable		 2f8lA-4dhgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA H 636
GLY H 470
LEU H 472
VAL H 653
GLY H 651
 None
 1.12A 2f8lA-4fxgH:
undetectable		 2f8lA-4fxgH:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ASN A  43
LEU A  32
VAL A 337
LEU A  36
GLY A 356
 None
 1.12A 2f8lA-4fxsA:
undetectable		 2f8lA-4fxsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		5 ALA A 186
ASP A 197
GLY A 182
ASP A 190
PRO A 216
 None
 0.99A 2f8lA-4g25A:
undetectable		 2f8lA-4g25A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		5 GLY A 350
VAL A 345
GLY A 343
ASP A 325
PRO A 327
 None
 1.15A 2f8lA-4hn8A:
2.1		 2f8lA-4hn8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ASN A  43
LEU A  32
VAL A 337
LEU A  36
GLY A 356
 None
 1.12A 2f8lA-4ix2A:
undetectable		 2f8lA-4ix2A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ALA A 635
GLY A 462
LEU A 464
VAL A 653
GLY A 651
 None
 1.15A 2f8lA-4j1yA:
undetectable		 2f8lA-4j1yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  36
LEU A 139
VAL A  38
GLY A  60
PRO A 331
 None
 1.13A 2f8lA-4jbhA:
7.5		 2f8lA-4jbhA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		6 ALA A 361
GLY A 370
ASN A 399
LEU A 371
GLY A 332
ASP A 366
 None
 1.33A 2f8lA-4ldpA:
3.8		 2f8lA-4ldpA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyn RIBONUCLEASE HI

(Halobacterium
salinarum) 		PF13456
(RVT_3) 		5 ALA A  86
GLY A  76
ASN A 112
ASP A 189
GLY A 103
 None
None
None
MN  A 302 (-3.1A)
None
 1.14A 2f8lA-4nynA:
undetectable		 2f8lA-4nynA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz0 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Bacillus
anthracis) 		PF13407
(Peripla_BP_4) 		5 ALA A  37
ASN A 286
VAL A  96
LEU A 119
ASP A  92
 None
 1.01A 2f8lA-4pz0A:
undetectable		 2f8lA-4pz0A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 GLY A  75
LEU A  77
VAL A 328
LEU A 310
ASP A  78
 None
 1.14A 2f8lA-4q69A:
undetectable		 2f8lA-4q69A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 HIS A 554
ALA A 519
GLY A 505
ASP A 556
GLY A 508
 None
 1.15A 2f8lA-4qdrA:
undetectable		 2f8lA-4qdrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		5 ALA A 127
GLY A 125
LEU A 149
LEU A 124
GLY A 136
 EDO  A 303 ( 3.2A)
None
EDO  A 303 ( 4.0A)
None
None
 1.12A 2f8lA-4r3fA:
undetectable		 2f8lA-4r3fA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3s CELLULOSOMAL
SCAFFOLDIN

(Acetivibrio
cellulolyticus) 		PF13620
(CarboxypepD_reg) 		5 LEU B  93
VAL B 170
ASP B 169
LEU B 159
ASP B 121
 None
None
CA  B 202 (-2.1A)
None
CA  B 201 (-3.3A)
 1.14A 2f8lA-4u3sB:
undetectable		 2f8lA-4u3sB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		6 HIS A 392
GLY A  74
ASN A  95
LEU A  96
ASP A 394
LEU A  75
 None
 1.46A 2f8lA-4uphA:
undetectable		 2f8lA-4uphA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 ALA A  50
GLY A  84
LEU A  60
LEU A 108
PRO A  18
 None
 1.04A 2f8lA-4ur8A:
undetectable		 2f8lA-4ur8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wi0 CELLULOSOMAL
SCAFFOLDIN

(Acetivibrio
cellulolyticus) 		PF13620
(CarboxypepD_reg) 		5 LEU B  93
VAL B 170
ASP B 169
LEU B 159
ASP B 121
 None
None
CA  B 202 (-2.2A)
None
CA  B 201 (-3.3A)
 1.13A 2f8lA-4wi0B:
undetectable		 2f8lA-4wi0B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 492
VAL A 256
ASP A 364
GLY A 306
PRO A 359
 None
 1.11A 2f8lA-4zi6A:
2.1		 2f8lA-4zi6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		5 HIS A 102
ALA A 203
GLY A 104
GLY A  16
ASP A 119
 FE2  A 301 (-3.5A)
None
None
None
None
 1.06A 2f8lA-4zpiA:
undetectable		 2f8lA-4zpiA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp1 CURK

(Moorea
producens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 249
ASN A 228
LEU A 227
ASP A 272
GLY A 142
 None
 0.98A 2f8lA-5dp1A:
8.0		 2f8lA-5dp1A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 HIS A 427
ALA A 399
GLY A 406
VAL A 374
GLY A 350
 None
 1.15A 2f8lA-5e6sA:
undetectable		 2f8lA-5e6sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		5 GLY B 341
ASN B  60
LEU B  61
GLY B 376
PHE B 333
 None
 1.15A 2f8lA-5ey5B:
2.1		 2f8lA-5ey5B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		5 ALA A  56
LEU A  47
ASP A  85
GLY A  60
PHE A  11
 None
 1.12A 2f8lA-5hj7A:
undetectable		 2f8lA-5hj7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 ALA A1164
GLY A1153
VAL A1126
GLY A1124
ASP A1075
 None
6A8  A1201 (-3.9A)
None
None
6A8  A1201 ( 4.2A)
 1.03A 2f8lA-5idkA:
undetectable		 2f8lA-5idkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Streptococcus
pneumoniae) 		PF00290
(Trp_syntA) 		5 HIS A 201
ALA A 176
LEU A 166
ASP A 228
GLY A 211
 None
 1.11A 2f8lA-5kinA:
undetectable		 2f8lA-5kinA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		5 GLY B 349
ASN B  67
LEU B  68
GLY B 384
PHE B 341
 None
 1.09A 2f8lA-5kinB:
2.2		 2f8lA-5kinB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 HIS A 855
ALA A 806
ASN A 799
LEU A 802
VAL A 811
 None
 1.01A 2f8lA-5m59A:
2.9		 2f8lA-5m59A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 ASN A 385
LEU A 384
VAL A 373
GLY A 361
PRO A 328
 NAG  A 509 (-1.8A)
None
None
None
None
 1.08A 2f8lA-5m8tA:
undetectable		 2f8lA-5m8tA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 ALA A 273
GLY A 275
LEU A 276
ASP A 269
PRO A 268
 None
 1.10A 2f8lA-5olcA:
undetectable		 2f8lA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		5 HIS B 199
GLY B 196
ASP B 194
GLY B 102
ASP B  82
 None
 1.01A 2f8lA-5osnB:
undetectable		 2f8lA-5osnB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		5 HIS B 199
GLY B 196
ASP B 194
GLY B 103
ASP B  82
 None
 1.04A 2f8lA-5osnB:
undetectable		 2f8lA-5osnB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ALA A  92
GLY A  94
LEU A  97
PRO A  89
PHE A  88
 None
 1.08A 2f8lA-5tzyA:
undetectable		 2f8lA-5tzyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ALA A 365
GLY A 363
VAL A 357
ASP A 358
PHE A 331
 None
None
GLC  A 810 ( 4.9A)
None
None
 0.94A 2f8lA-5x7hA:
undetectable		 2f8lA-5x7hA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 ALA A 109
GLY A 112
LEU A 257
VAL A  82
ASP A  81
 None
 1.14A 2f8lA-5xl2A:
undetectable		 2f8lA-5xl2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 ALA A 109
GLY A 112
LEU A 257
VAL A  82
ASP A  81
 None
 1.12A 2f8lA-5xl6A:
undetectable		 2f8lA-5xl6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1

(Electrophorus
electricus) 		no annotation 5 ASN B 113
LEU B 112
VAL B  84
ASP B  86
GLY B  82
 NAG  B 302 (-1.9A)
None
None
None
None
 1.04A 2f8lA-5xsyB:
undetectable		 2f8lA-5xsyB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 5 GLY A 642
VAL A 668
GLY A 646
ASP A 637
PHE A 635
 None
 1.14A 2f8lA-5yemA:
2.0		 2f8lA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 5 GLY B  89
LEU B  84
ASP B 389
LEU B 392
PRO B 174
 None
 1.09A 2f8lA-6c2jB:
undetectable		 2f8lA-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 6 ALA B 257
ASN B 226
LEU B 228
ASP B 240
LEU B 241
PRO B 235
 None
 1.31A 2f8lA-6c6lB:
undetectable		 2f8lA-6c6lB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ALA A 120
VAL A 127
LEU A 138
PRO A  46
PHE A  30
 None
 1.03A 2f8lA-6f8zA:
undetectable		 2f8lA-6f8zA:
undetectable