SIMILAR PATTERNS OF AMINO ACIDS FOR 2F8D_A_BEZA1002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		5 GLY A 210
LEU A 211
LEU A 212
ILE A  61
PHE A 193
 None
 0.99A 2f8dA-1b0zA:
undetectable		 2f8dA-1b0zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		5 LEU A 249
GLY A 246
LEU A 244
LEU A 283
ILE A   2
 None
 0.98A 2f8dA-1cnvA:
undetectable		 2f8dA-1cnvA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 GLY A 219
LEU A 220
LEU A 218
ARG A 216
TYR A 239
 None
 1.07A 2f8dA-1cpyA:
undetectable		 2f8dA-1cpyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 170
LEU A 171
ILE A 177
LEU A  94
ILE A  97
 None
 1.06A 2f8dA-1gsqA:
0.5		 2f8dA-1gsqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		5 GLY A 132
LEU A 136
LEU A 134
PHE A 100
TYR A 258
 None
 0.99A 2f8dA-1hi9A:
1.0		 2f8dA-1hi9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		5 GLY A 296
LEU A 297
LEU A 295
ILE A 299
TYR A 189
 None
 1.05A 2f8dA-1ibqA:
undetectable		 2f8dA-1ibqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 390
GLY A 387
LEU A 389
ILE A 367
LEU A  65
 None
CPR  A 631 (-3.7A)
None
None
None
 1.01A 2f8dA-1jcnA:
0.0		 2f8dA-1jcnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU B 330
LEU B 329
ILE B 326
LEU B 406
ILE B 403
 None
 1.02A 2f8dA-1m2vB:
2.2		 2f8dA-1m2vB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 141
GLY A 119
LEU A 120
ILE A 122
LEU A 110
 None
 1.04A 2f8dA-1nytA:
0.0		 2f8dA-1nytA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02932
(Neur_chan_memb)
PF02932
(Neur_chan_memb) 		5 LEU B 241
LEU B 234
LEU B 237
ILE B 233
LEU C 264
 None
 1.09A 2f8dA-1oedB:
undetectable		 2f8dA-1oedB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6F
COMPLEX SUBUNIT PETL

(Chlamydomonas
reinhardtii) 		PF05115
(PetL) 		5 LEU L  23
GLY L  24
LEU L  25
LEU L  26
ILE L  32
 None
 0.93A 2f8dA-1q90L:
undetectable		 2f8dA-1q90L:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ss4 GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF13669
(Glyoxalase_4) 		5 GLY A 142
LEU A 143
LEU A 130
ILE A 103
LEU A 117
 None
 1.11A 2f8dA-1ss4A:
undetectable		 2f8dA-1ss4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		5 LEU A 115
GLY A 119
LEU A 120
ILE A  99
LEU A  86
 None
 1.10A 2f8dA-1tv8A:
undetectable		 2f8dA-1tv8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.07A 2f8dA-1vkoA:
undetectable		 2f8dA-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3

(Mus musculus) 		PF04051
(TRAPP) 		5 LEU A 130
GLY A 133
LEU A 131
LEU A  55
ILE A  51
 None
None
None
MYR  A1168 ( 4.9A)
None
 1.05A 2f8dA-1wc8A:
undetectable		 2f8dA-1wc8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 LEU A 106
GLY A  96
ILE A 133
LEU A 148
ILE A 151
 None
 1.06A 2f8dA-1yk3A:
undetectable		 2f8dA-1yk3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		5 LEU A 208
GLY A 210
LEU A 212
ILE A 215
LEU A 236
 None
 1.04A 2f8dA-1z7mA:
undetectable		 2f8dA-1z7mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		5 GLY A 169
LEU A 168
ILE A 216
PHE A 165
ARG A 223
 None
 0.83A 2f8dA-2cxiA:
undetectable		 2f8dA-2cxiA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 LEU A 682
GLY A 684
LEU A 690
LEU A 685
ILE A 649
 None
 1.10A 2f8dA-2eaeA:
undetectable		 2f8dA-2eaeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A  58
LEU A  57
PHE A  51
LEU A  82
ILE A  78
 None
 1.08A 2f8dA-2ebaA:
undetectable		 2f8dA-2ebaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 LEU A 375
LEU A 368
ILE A 352
LEU A 320
ILE A 317
 None
 1.11A 2f8dA-2f5uA:
undetectable		 2f8dA-2f5uA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		10 LEU A 100
GLY A 103
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 None
 0.39A 2f8dA-2f6gA:
33.3		 2f8dA-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		6 LEU A   3
LEU A  57
ILE A  63
LEU A 101
ARG A 100
ILE A   5
 None
 1.03A 2f8dA-2fe7A:
undetectable		 2f8dA-2fe7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.04A 2f8dA-2fi1A:
undetectable		 2f8dA-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 LEU A  22
GLY A  23
LEU A  19
ILE A   9
LEU A 284
 None
 1.00A 2f8dA-2ghbA:
3.5		 2f8dA-2ghbA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		8 LEU A 100
GLY A 103
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.59A 2f8dA-2h98A:
30.0		 2f8dA-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 GLY A 317
LEU A 318
LEU A 319
ILE A 326
LEU A 354
 None
 0.80A 2f8dA-2hpiA:
undetectable		 2f8dA-2hpiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 316
GLY A 317
LEU A 318
LEU A 319
LEU A 354
 None
 1.05A 2f8dA-2hpiA:
undetectable		 2f8dA-2hpiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khe TOXIN-LIKE PROTEIN

(Thermus
thermophilus) 		PF05016
(ParE_toxin) 		6 LEU A  47
LEU A  52
PHE A  55
LEU A  79
ARG A  80
ILE A  66
 None
 1.28A 2f8dA-2kheA:
undetectable		 2f8dA-2kheA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.08A 2f8dA-3b3jA:
undetectable		 2f8dA-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.76A 2f8dA-3bg0B:
undetectable		 2f8dA-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 LEU A 313
LEU A 319
PHE A 291
LEU A 157
ILE A 311
 None
 1.05A 2f8dA-3ct4A:
undetectable		 2f8dA-3ct4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		5 GLY A  86
LEU A  88
LEU A  89
ILE A  92
LEU A 403
 None
 1.01A 2f8dA-3focA:
undetectable		 2f8dA-3focA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		5 GLY A4059
LEU A4062
LEU A4061
ILE A4048
ARG A4122
 None
 0.81A 2f8dA-3g1nA:
undetectable		 2f8dA-3g1nA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		8 LEU A 100
GLY A 103
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 GOL  A   2 (-4.3A)
GOL  A   2 (-3.6A)
GOL  A   2 (-3.7A)
None
None
None
None
GOL  A   2 (-4.9A)
 0.46A 2f8dA-3glbA:
29.9		 2f8dA-3glbA:
54.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		5 LEU A 103
GLY A  60
LEU A  62
ILE A  63
ILE A 126
 None
 0.85A 2f8dA-3gveA:
undetectable		 2f8dA-3gveA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		5 LEU B 223
LEU B 222
ILE B 216
LEU B 350
ILE B 353
 None
 1.05A 2f8dA-3j9oB:
undetectable		 2f8dA-3j9oB:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		10 LEU A 100
GLY A 103
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 IMD  A 313 ( 4.1A)
CL  A 314 ( 4.1A)
CL  A 314 ( 4.1A)
IMD  A 313 ( 4.0A)
None
IMD  A 313 ( 4.9A)
None
CL  A 314 (-3.4A)
IMD  A 313 ( 4.1A)
IMD  A 313 (-4.7A)
 0.51A 2f8dA-3k1nA:
34.1		 2f8dA-3k1nA:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		5 LEU A 118
GLY A 117
LEU A 120
LEU A 119
LEU A  83
 None
 0.94A 2f8dA-3kq5A:
undetectable		 2f8dA-3kq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN

(Pyrococcus
horikoshii) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 GLY A  84
LEU A  83
ILE A  61
PHE A  25
LEU A  22
 None
 1.00A 2f8dA-3npgA:
undetectable		 2f8dA-3npgA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 LEU A 107
GLY A 108
LEU A 109
LEU A 110
ILE A  81
 None
 1.07A 2f8dA-3t3oA:
undetectable		 2f8dA-3t3oA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 LEU A 379
GLY A 377
LEU A 376
LEU A 375
ILE A 372
 None
None
None
None
DMU  A 420 (-3.9A)
 1.02A 2f8dA-3tijA:
undetectable		 2f8dA-3tijA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		5 LEU A 105
GLY A 103
LEU A 101
ILE A  98
ILE A 150
 None
 1.08A 2f8dA-3tr1A:
undetectable		 2f8dA-3tr1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 GLY A 310
LEU A 359
PHE A 291
ARG A 302
ILE A 292
 None
 1.08A 2f8dA-3vlaA:
undetectable		 2f8dA-3vlaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnf MEMBRANE-ASSOCIATED
PROTEIN VP24

(Sudan
ebolavirus) 		PF06389
(Filo_VP24) 		5 GLY A 117
LEU A 121
LEU A 119
ILE A 122
LEU A 145
 None
 1.04A 2f8dA-3vnfA:
undetectable		 2f8dA-3vnfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 194
LEU A 198
ILE A 199
PHE A 229
LEU A 121
 None
 0.99A 2f8dA-3vwaA:
undetectable		 2f8dA-3vwaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 GLY A 105
LEU A 108
ILE A 112
PHE A  96
LEU A 228
 None
 1.08A 2f8dA-3zuqA:
undetectable		 2f8dA-3zuqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		5 GLY A 271
LEU A 274
LEU A 275
ILE A 278
LEU A 336
 None
 1.04A 2f8dA-4arsA:
undetectable		 2f8dA-4arsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		5 GLY A 270
LEU A 273
LEU A 274
ILE A 277
LEU A 336
 None
 0.93A 2f8dA-4arvA:
undetectable		 2f8dA-4arvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 LEU A 288
GLY A 287
LEU A 219
ILE A 208
ILE A 278
 None
 0.99A 2f8dA-4az7A:
undetectable		 2f8dA-4az7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 422
GLY A 423
LEU A 419
ILE A 404
PHE A 382
 None
 1.09A 2f8dA-4b18A:
undetectable		 2f8dA-4b18A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 GLY A 210
LEU A 112
ILE A 154
PHE A 109
LEU A  33
 None
 1.10A 2f8dA-4cvuA:
undetectable		 2f8dA-4cvuA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6y BACTERIAL
REGULATORY, FIS
FAMILY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg) 		6 LEU A  61
GLY A  63
LEU A  67
LEU A  66
ILE A  70
ARG A  97
 None
 1.41A 2f8dA-4d6yA:
undetectable		 2f8dA-4d6yA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		5 LEU A 279
GLY A 278
LEU A 246
ILE A 272
ILE A 301
 None
 1.08A 2f8dA-4eysA:
1.7		 2f8dA-4eysA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		5 GLY A 237
LEU A 215
ILE A 233
PHE A 218
LEU A 241
 None
 1.03A 2f8dA-4fcgA:
undetectable		 2f8dA-4fcgA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 548
LEU A 552
LEU A 550
LEU A 260
ILE A 251
 None
 0.88A 2f8dA-4fsfA:
undetectable		 2f8dA-4fsfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 GLY A  84
LEU A  86
LEU A  87
ILE A  90
LEU A 334
 None
 0.87A 2f8dA-4k6nA:
undetectable		 2f8dA-4k6nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9q ARF-LIKE GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		5 GLY A 176
LEU A 177
LEU A 173
ILE A  39
LEU A  24
 None
 0.95A 2f8dA-4m9qA:
undetectable		 2f8dA-4m9qA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		5 GLY A 558
LEU A 559
LEU A 557
ILE A 533
TYR A 498
 None
 1.11A 2f8dA-4mfvA:
undetectable		 2f8dA-4mfvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		5 LEU A 557
GLY A 558
LEU A 559
LEU A 560
TYR A 498
 None
 1.10A 2f8dA-4mfvA:
undetectable		 2f8dA-4mfvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 721
GLY A 719
LEU A 723
LEU A 722
ARG A 728
 None
 1.11A 2f8dA-4n78A:
undetectable		 2f8dA-4n78A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 GLY A 589
LEU A 590
ILE A 592
LEU A 727
ILE A 570
 None
 1.11A 2f8dA-4ncnA:
undetectable		 2f8dA-4ncnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		5 LEU A 223
GLY A 224
ILE A 200
LEU A 382
ILE A 384
 None
 1.03A 2f8dA-4ofwA:
undetectable		 2f8dA-4ofwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		5 LEU A 223
GLY A 224
LEU A 220
ILE A 200
ILE A 384
 None
 1.11A 2f8dA-4ofwA:
undetectable		 2f8dA-4ofwA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 5 LEU A 529
GLY A 530
PHE A 514
LEU A 483
ILE A 507
 None
 0.90A 2f8dA-4po6A:
undetectable		 2f8dA-4po6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		5 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.92A 2f8dA-4q3lA:
undetectable		 2f8dA-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 GLY A 149
LEU A 148
LEU A  82
ILE A  80
ILE A 176
 None
 1.07A 2f8dA-4qpnA:
undetectable		 2f8dA-4qpnA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 LEU A 254
LEU A 258
ILE A 261
LEU A 242
ILE A 245
 None
 1.10A 2f8dA-4rbnA:
1.1		 2f8dA-4rbnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2x IMPORTIN SUBUNIT
ALPHA-6

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU D 423
GLY D 424
LEU D 420
ILE D 405
PHE D 383
 None
 1.10A 2f8dA-4u2xD:
undetectable		 2f8dA-4u2xD:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 420
GLY A 421
LEU A 417
ILE A 402
PHE A 380
 None
 1.08A 2f8dA-4uadA:
undetectable		 2f8dA-4uadA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 LEU A 392
GLY A  61
LEU A  59
LEU A  11
ILE A 384
 None
 1.10A 2f8dA-4v1yA:
undetectable		 2f8dA-4v1yA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF00155
(Aminotran_1_2) 		5 GLY A 100
LEU A  96
ILE A 126
LEU A 134
ILE A 113
 None
 1.05A 2f8dA-4w5kA:
1.5		 2f8dA-4w5kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 537
ILE B 533
LEU B 519
ARG B 520
ILE B 516
 None
 0.85A 2f8dA-4xmmB:
undetectable		 2f8dA-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xng UNCHARACTERIZED
PROTEIN MG218.1

(Mycoplasma
genitalium) 		no annotation 5 LEU A 138
ILE A 134
LEU A 181
ARG A 182
ILE A 178
 None
 0.98A 2f8dA-4xngA:
undetectable		 2f8dA-4xngA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 GLY A 246
LEU A 248
ILE A 251
LEU A 205
ILE A 202
 None
 1.01A 2f8dA-4xriA:
undetectable		 2f8dA-4xriA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.99A 2f8dA-5b3jA:
undetectable		 2f8dA-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 5 LEU A 434
ILE A 317
PHE A 439
LEU A 461
ILE A 436
 None
 1.11A 2f8dA-5cowA:
undetectable		 2f8dA-5cowA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 GLY A  55
LEU A  59
LEU A  56
LEU A 300
ILE A 297
 None
 1.09A 2f8dA-5husA:
undetectable		 2f8dA-5husA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A  18
GLY A  16
LEU A  14
ILE A  11
ILE A 165
 None
None
None
NAP  A 401 (-3.9A)
None
 0.96A 2f8dA-5hwsA:
undetectable		 2f8dA-5hwsA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 LEU B 384
GLY B 383
LEU B 359
ILE B 356
ILE B 403
 None
 1.00A 2f8dA-5hzgB:
undetectable		 2f8dA-5hzgB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 LEU F 148
GLY F 146
LEU F 144
ILE F  87
PHE F 152
 None
 1.05A 2f8dA-5mmiF:
undetectable		 2f8dA-5mmiF:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		5 GLY A 332
LEU A 333
LEU A 330
ILE A 218
ARG A  79
 None
 1.09A 2f8dA-5ny5A:
undetectable		 2f8dA-5ny5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 GLY A 332
LEU A 333
LEU A 330
ILE A 218
ARG A  79
 None
None
9JE  A 601 ( 4.3A)
None
None
 1.04A 2f8dA-5o3mA:
undetectable		 2f8dA-5o3mA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 21

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF11221
(Med21) 		5 LEU W  80
ILE W  73
LEU U 119
ARG U 120
ILE U 116
 None
 1.08A 2f8dA-5svaW:
undetectable		 2f8dA-5svaW:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 LEU A  18
GLY A 208
LEU A 207
LEU A 200
ARG A 201
 None
None
None
None
C90  A 502 (-3.3A)
 1.07A 2f8dA-5u39A:
undetectable		 2f8dA-5u39A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 GLY 5 537
ILE 5 540
PHE 5 550
LEU 5 413
ILE 5 553
 None
 0.98A 2f8dA-5udb5:
undetectable		 2f8dA-5udb5:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 LEU A 324
GLY A  20
LEU A  22
LEU A  23
ILE A  26
 None
 0.91A 2f8dA-5urbA:
undetectable		 2f8dA-5urbA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4b GTPASE DER

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 LEU A 156
GLY A 153
LEU A 155
ILE A 144
ILE A  23
 None
K  A 202 (-3.7A)
None
None
None
 0.87A 2f8dA-5x4bA:
undetectable		 2f8dA-5x4bA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 GLY A 449
LEU A 447
LEU A 451
ILE A 360
ILE A  47
 None
 1.03A 2f8dA-5x8oA:
undetectable		 2f8dA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 5 LEU A 454
GLY A 455
LEU A 456
LEU A 457
ILE A 498
 None
 0.92A 2f8dA-5yx9A:
undetectable		 2f8dA-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 377
GLY A 374
LEU A 376
ILE A 419
LEU A 331
 None
 0.97A 2f8dA-5zb3A:
undetectable		 2f8dA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 377
LEU A 376
ILE A 419
LEU A 331
ILE A 344
 None
 1.09A 2f8dA-5zb3A:
undetectable		 2f8dA-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 5 LEU A 399
GLY A 366
LEU A 380
LEU A 332
ILE A 328
 None
 1.06A 2f8dA-6a8mA:
undetectable		 2f8dA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 LEU A1299
GLY A1298
LEU A1307
LEU A1309
ARG A1300
 None
 1.05A 2f8dA-6bhuA:
undetectable		 2f8dA-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4

(Homo sapiens) 		no annotation 5 LEU A 209
GLY A 210
LEU A 211
LEU A 213
LEU A 281
 None
 1.11A 2f8dA-6cnoA:
undetectable		 2f8dA-6cnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3

(Homo sapiens) 		no annotation 5 LEU A 385
GLY A 386
LEU A 387
LEU A 388
ILE A 429
 None
 0.97A 2f8dA-6cudA:
undetectable		 2f8dA-6cudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 5 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.93A 2f8dA-6d2lA:
undetectable		 2f8dA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek4 PAXB

(Photorhabdus
luminescens) 		no annotation 5 LEU A 275
GLY A 277
ILE A 282
ARG A 159
ILE A 163
 None
 0.93A 2f8dA-6ek4A:
undetectable		 2f8dA-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 5 LEU A 100
GLY A 101
LEU A 137
LEU A  26
ILE A  72
 None
 1.11A 2f8dA-6es9A:
undetectable		 2f8dA-6es9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 448
GLY A 470
LEU A 468
ILE A 465
LEU A 474
 None
 0.98A 2f8dA-6g9oA:
undetectable		 2f8dA-6g9oA:
undetectable