SIMILAR PATTERNS OF AMINO ACIDS FOR 2F8D_A_BEZA1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csy SYK PROTEIN TYROSINE
KINASE

(Homo sapiens) 		PF00017
(SH2) 		4 VAL A  29
SER A  33
LEU A  61
HIS A  56
 None
 1.26A 2f8dA-1csyA:
0.8		 2f8dA-1csyA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		4 VAL A 513
SER A 312
ARG A 470
LEU A 469
 None
 1.03A 2f8dA-1dcqA:
0.0		 2f8dA-1dcqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 VAL A 568
LEU A 300
PHE A 201
HIS A 204
 None
 1.29A 2f8dA-1ebvA:
0.0		 2f8dA-1ebvA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		4 VAL A 131
SER A  53
ARG A  61
HIS A  64
 None
None
TYD  A2187 (-3.7A)
TYD  A2187 (-4.3A)
 0.82A 2f8dA-1epzA:
0.0		 2f8dA-1epzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j89 HIGH AFFINITY
IMMUNOGLOBULIN
EPSILON RECEPTOR
ALPHA-SUBUNIT

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		4 VAL A   7
SER A  76
LEU A  53
PHE A  40
 None
 0.95A 2f8dA-1j89A:
undetectable		 2f8dA-1j89A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 VAL A 364
SER A 362
LEU A 437
PHE A   4
 None
 1.27A 2f8dA-1js4A:
undetectable		 2f8dA-1js4A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 VAL A 346
LEU A 318
PHE A 303
HIS A 305
 None
 1.34A 2f8dA-1mz5A:
0.0		 2f8dA-1mz5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		4 VAL A 107
SER A  21
ARG A 183
HIS A 186
 None
 1.22A 2f8dA-1nqzA:
0.0		 2f8dA-1nqzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A 211
ARG A 207
LEU A 205
HIS A 216
 None
 1.32A 2f8dA-1r6aA:
0.4		 2f8dA-1r6aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		4 VAL A 169
SER A 171
ARG A 134
HIS A 131
 None
 1.33A 2f8dA-1tc5A:
undetectable		 2f8dA-1tc5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upi DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Mycobacterium
tuberculosis) 		PF00908
(dTDP_sugar_isom) 		4 VAL A 130
SER A  51
ARG A  59
HIS A  62
 None
 0.95A 2f8dA-1upiA:
undetectable		 2f8dA-1upiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		4 VAL A  55
ARG A 376
LEU A  58
HIS A 379
 None
 1.17A 2f8dA-1vgqA:
undetectable		 2f8dA-1vgqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		4 VAL A 118
SER A 116
LEU A  93
PHE A 111
 None
 1.18A 2f8dA-1vhkA:
undetectable		 2f8dA-1vhkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		4 VAL A 128
SER A  50
ARG A  58
HIS A  61
 None
 0.87A 2f8dA-1wltA:
undetectable		 2f8dA-1wltA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 VAL A 178
SER A 177
LEU A 237
HIS A 239
 None
 1.35A 2f8dA-1z2zA:
undetectable		 2f8dA-1z2zA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Thermus
aquaticus) 		no annotation 4 VAL D 347
ARG D 209
LEU D 387
PHE D 207
 None
 1.12A 2f8dA-2aujD:
undetectable		 2f8dA-2aujD:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9u HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		4 VAL A 128
SER A  50
ARG A  58
HIS A  61
 None
 0.86A 2f8dA-2b9uA:
undetectable		 2f8dA-2b9uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha) 		4 SER A 169
ARG A 174
LEU A 127
PHE A 175
 CSO  A 121 ( 4.0A)
CSO  A 121 ( 3.3A)
None
None
 1.23A 2f8dA-2dppA:
undetectable		 2f8dA-2dppA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		4 VAL A  80
LEU A  22
PHE A  76
HIS A  75
 None
 1.11A 2f8dA-2e1tA:
undetectable		 2f8dA-2e1tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		4 VAL A 230
SER A  88
LEU A 244
PHE A  83
 None
 1.34A 2f8dA-2e7jA:
undetectable		 2f8dA-2e7jA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		4 VAL A 202
SER A 185
LEU A 217
HIS A 233
 None
 1.14A 2f8dA-2ehhA:
undetectable		 2f8dA-2ehhA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		6 VAL A  97
SER A  99
ARG A 146
LEU A 147
PHE A 203
HIS A 206
 None
 0.68A 2f8dA-2f6gA:
33.3		 2f8dA-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 621
SER A 816
ARG A 620
LEU A 604
 None
 1.28A 2f8dA-2gv9A:
undetectable		 2f8dA-2gv9A:
12.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 VAL A  97
SER A  99
ARG A 146
LEU A 147
 CL  A 315 ( 4.6A)
CL  A 314 (-2.9A)
None
None
 1.17A 2f8dA-2h98A:
30.0		 2f8dA-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixc DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
RMLC

(Mycobacterium
tuberculosis) 		PF00908
(dTDP_sugar_isom) 		4 VAL A 130
SER A  51
ARG A  59
HIS A  62
 None
TRH  A1199 ( 4.8A)
TRH  A1199 (-4.0A)
TRH  A1199 (-3.5A)
 0.85A 2f8dA-2ixcA:
undetectable		 2f8dA-2ixcA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk6 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FER

(Homo sapiens) 		PF00017
(SH2) 		4 VAL A 103
SER A 101
ARG A  62
HIS A  63
 None
 0.87A 2f8dA-2kk6A:
undetectable		 2f8dA-2kk6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2leh SURVIVAL OF MOTOR
NEURON
PROTEIN-INTERACTING
PROTEIN 1
SURVIVAL MOTOR
NEURON PROTEIN

(Homo sapiens;
Homo sapiens) 		PF04938
(SIP1)
PF06003
(SMN) 		4 VAL A 183
SER A 184
LEU B  39
HIS A 120
 None
 1.28A 2f8dA-2lehA:
undetectable		 2f8dA-2lehA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7u METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 VAL A 460
SER A 477
ARG A 452
LEU A 455
 None
 1.11A 2f8dA-2m7uA:
undetectable		 2f8dA-2m7uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 SER A 335
ARG A 339
LEU A 306
PHE A 333
 None
 1.29A 2f8dA-2n0sA:
undetectable		 2f8dA-2n0sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 318
ARG A 321
LEU A 296
HIS A 268
 None
 1.24A 2f8dA-2oqhA:
undetectable		 2f8dA-2oqhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X 294
SER X 292
LEU X 336
HIS X 337
 None
 1.16A 2f8dA-2p3gX:
undetectable		 2f8dA-2p3gX:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 SER A 168
ARG A 251
LEU A 250
PHE A 170
 None
None
HEC  A 402 (-4.9A)
None
 1.24A 2f8dA-2vhdA:
undetectable		 2f8dA-2vhdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 VAL A 364
SER A 362
LEU A 436
PHE A   4
 None
 1.29A 2f8dA-2xfgA:
undetectable		 2f8dA-2xfgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 VAL A  66
SER A  70
ARG A  79
PHE A   6
 EDO  A 401 ( 4.3A)
EDO  A 401 (-3.6A)
None
None
 1.25A 2f8dA-3bjdA:
undetectable		 2f8dA-3bjdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		4 VAL A 141
SER A  90
LEU A 137
HIS A 375
 None
 1.26A 2f8dA-3c87A:
undetectable		 2f8dA-3c87A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA

(Methylosinus
trichosporium) 		PF02461
(AMO) 		4 VAL B  57
SER B 122
PHE B 193
HIS B 192
 None
 1.21A 2f8dA-3chxB:
undetectable		 2f8dA-3chxB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3s L-2,4-DIAMINOBUTYRIC
ACID
ACETYLTRANSFERASE

(Bordetella
parapertussis) 		PF00583
(Acetyltransf_1) 		4 SER A  49
ARG A  53
LEU A  18
HIS A  78
 SO4  A 165 (-2.7A)
SO4  A 165 (-3.3A)
GOL  A 168 (-4.1A)
GOL  A 168 (-4.1A)
 1.27A 2f8dA-3d3sA:
undetectable		 2f8dA-3d3sA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 423
LEU A 465
PHE A 415
HIS A 416
 None
 1.32A 2f8dA-3e7wA:
undetectable		 2f8dA-3e7wA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A  56
SER A  49
LEU A 114
PHE A 107
 None
 1.32A 2f8dA-3fahA:
undetectable		 2f8dA-3fahA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A 184
SER A 340
LEU A  51
PHE A  48
 None
 1.32A 2f8dA-3fgqA:
undetectable		 2f8dA-3fgqA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 VAL A  97
SER A  99
ARG A 146
LEU A 147
 CCU  A   3 (-4.2A)
CCU  A   3 (-2.9A)
None
CCU  A   3 (-4.4A)
 0.57A 2f8dA-3glbA:
20.7		 2f8dA-3glbA:
54.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 VAL A  97
SER A  99
ARG A 146
PHE A 203
 CCU  A   3 (-4.2A)
CCU  A   3 (-2.9A)
None
None
 0.94A 2f8dA-3glbA:
20.7		 2f8dA-3glbA:
54.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		4 VAL A 106
SER A 105
LEU A 258
HIS A  38
 None
 1.10A 2f8dA-3gzjA:
0.8		 2f8dA-3gzjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		4 VAL A 331
LEU A 338
PHE A  13
HIS A  25
 None
 1.32A 2f8dA-3hgoA:
undetectable		 2f8dA-3hgoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533

(Methanocaldococcus
jannaschii) 		PF01850
(PIN) 		4 VAL A  35
SER A 135
ARG A  40
LEU A  44
 None
None
ACT  A 168 ( 4.1A)
None
 1.15A 2f8dA-3i8oA:
undetectable		 2f8dA-3i8oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 VAL A 762
LEU A 752
PHE A 750
HIS A 733
 None
 1.34A 2f8dA-3ikmA:
0.9		 2f8dA-3ikmA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 280
SER A 306
ARG A 157
LEU A 155
 None
 0.84A 2f8dA-3jtmA:
undetectable		 2f8dA-3jtmA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		6 VAL A  97
SER A  99
ARG A 146
LEU A 147
PHE A 203
HIS A 206
 None
 0.64A 2f8dA-3k1nA:
22.3		 2f8dA-3k1nA:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3las PUTATIVE CARBONIC
ANHYDRASE

(Streptococcus
mutans) 		PF00484
(Pro_CA) 		4 VAL A 131
SER A 130
LEU A  89
HIS A  91
 None
None
None
ZN  A 167 (-3.2A)
 0.95A 2f8dA-3lasA:
undetectable		 2f8dA-3lasA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkz FLAGELLAR PROTEIN
FLIT

(Yersinia
enterocolitica) 		PF05400
(FliT) 		4 SER A  -2
ARG A   3
LEU A   7
HIS A   4
 None
SO4  A 121 ( 3.4A)
None
SO4  A 121 (-3.9A)
 1.26A 2f8dA-3nkzA:
undetectable		 2f8dA-3nkzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 VAL A 338
SER A 343
LEU A 278
HIS A 282
 None
 1.17A 2f8dA-3nqxA:
0.5		 2f8dA-3nqxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		4 VAL A 205
SER A 188
LEU A 220
HIS A 236
 None
 1.26A 2f8dA-3pb0A:
undetectable		 2f8dA-3pb0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 VAL A  82
SER A  83
ARG A  79
HIS A 133
 None
 1.27A 2f8dA-3pxxA:
undetectable		 2f8dA-3pxxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qve HMG BOX-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08517
(AXH) 		4 VAL A 328
SER A 310
LEU A 280
HIS A 300
 None
 1.33A 2f8dA-3qveA:
undetectable		 2f8dA-3qveA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 VAL A 119
SER A 118
LEU A 210
PHE A 104
 None
 1.32A 2f8dA-3r2tA:
undetectable		 2f8dA-3r2tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOA

(Methylocystis
sp. M) 		no annotation 4 VAL J  57
SER J 122
PHE J 193
HIS J 192
 None
 1.00A 2f8dA-3rfrJ:
undetectable		 2f8dA-3rfrJ:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 VAL A 358
SER A 359
ARG A 355
PHE A 194
 None
 0.99A 2f8dA-3ss6A:
undetectable		 2f8dA-3ss6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl4 GLUTAMINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF04558
(tRNA_synt_1c_R1) 		4 VAL X 122
SER X 165
LEU X 155
PHE X 149
 None
 1.34A 2f8dA-3tl4X:
undetectable		 2f8dA-3tl4X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3g RIBONUCLEASE H

(uncultured
organism) 		no annotation 4 VAL D  23
SER D  36
ARG D  55
LEU D  60
 None
 1.30A 2f8dA-3u3gD:
undetectable		 2f8dA-3u3gD:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9g ZINC FINGER
CCCH-TYPE ANTIVIRAL
PROTEIN 1

(Rattus
norvegicus) 		no annotation 4 SER A 141
ARG A  71
LEU A  85
HIS A 124
 None
 1.12A 2f8dA-3u9gA:
undetectable		 2f8dA-3u9gA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		4 VAL A   8
SER A 121
LEU A  98
HIS A  96
 CL  A 234 (-4.0A)
CL  A 234 (-2.5A)
None
None
 1.34A 2f8dA-3umcA:
undetectable		 2f8dA-3umcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv4 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 VAL A  32
SER A  49
ARG A  24
LEU A  27
 None
None
SO4  A 202 (-2.5A)
None
 1.29A 2f8dA-3vv4A:
undetectable		 2f8dA-3vv4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		4 VAL A 100
SER A  94
LEU A 134
HIS A 166
 None
 1.25A 2f8dA-3wgcA:
undetectable		 2f8dA-3wgcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 SER A 293
ARG A 324
LEU A 328
HIS A 139
 None
 1.13A 2f8dA-3zdfA:
undetectable		 2f8dA-3zdfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 VAL A 222
SER A 223
ARG A 242
HIS A 251
 GOL  A1375 ( 4.5A)
GOL  A1375 (-3.3A)
GOL  A1375 (-3.8A)
None
 1.30A 2f8dA-4czpA:
undetectable		 2f8dA-4czpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		4 VAL A 384
SER A 382
LEU A 456
PHE A  26
 None
 1.31A 2f8dA-4doeA:
undetectable		 2f8dA-4doeA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		4 VAL A 141
SER A 145
LEU A 160
PHE A 127
 None
 1.28A 2f8dA-4fymA:
undetectable		 2f8dA-4fymA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago
maydis;
Ustilago maydis) 		PF08661
(Rep_fac-A_3)
PF01336
(tRNA_anti-codon) 		4 VAL A  99
SER A 103
ARG B 163
HIS B 162
 None
 1.10A 2f8dA-4gnxA:
undetectable		 2f8dA-4gnxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goq HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF07372
(DUF1491) 		4 VAL A  36
LEU A  12
PHE A  51
HIS A 101
 None
 1.21A 2f8dA-4goqA:
undetectable		 2f8dA-4goqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im8 ADVANCED GLYCATION
END-PRODUCTS
RECEPTOR

(Mus musculus) 		PF00047
(ig)
PF08205
(C2-set_2) 		4 VAL A 172
SER A 189
LEU A 163
HIS A 157
 None
 1.03A 2f8dA-4im8A:
undetectable		 2f8dA-4im8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j75 TRYPTOPHANYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		PF00579
(tRNA-synt_1b) 		4 VAL A 600
LEU A 321
PHE A 518
HIS A 317
 None
 1.16A 2f8dA-4j75A:
0.9		 2f8dA-4j75A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2) 		4 VAL A 167
SER A 165
ARG A 152
LEU A 216
 None
 1.17A 2f8dA-4jegA:
undetectable		 2f8dA-4jegA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Salmonella
enterica) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 VAL A  13
SER A  10
ARG A   7
LEU A  31
 None
GSH  A 301 (-2.5A)
GSH  A 301 (-3.2A)
None
 1.29A 2f8dA-4kh7A:
undetectable		 2f8dA-4kh7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp4 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF08205
(C2-set_2) 		4 VAL A 173
SER A 190
LEU A 164
HIS A 158
 None
 1.13A 2f8dA-4lp4A:
undetectable		 2f8dA-4lp4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Bacillus
subtilis) 		no annotation 4 VAL A 237
ARG A  52
LEU A  49
PHE A  37
 None
 1.24A 2f8dA-4p8iA:
undetectable		 2f8dA-4p8iA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 4 VAL E 131
ARG E 191
LEU E 192
HIS E 195
 None
 1.15A 2f8dA-4p9uE:
undetectable		 2f8dA-4p9uE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q37 RADICAL SAM PROTEIN

(Thermotoga
maritima) 		PF02310
(B12-binding) 		4 VAL A  82
LEU A  90
PHE A  98
HIS A  96
 None
 1.26A 2f8dA-4q37A:
undetectable		 2f8dA-4q37A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 VAL A   8
SER A 152
LEU A 191
PHE A 156
 None
 1.28A 2f8dA-4r9zA:
undetectable		 2f8dA-4r9zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urp FATTY ACID
REPRESSION MUTANT
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00881
(Nitroreductase) 		4 VAL A  52
SER A  50
LEU A 100
PHE A 117
 None
 1.23A 2f8dA-4urpA:
undetectable		 2f8dA-4urpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 VAL A 359
SER A 360
LEU A 265
PHE A 262
 None
 1.27A 2f8dA-4xprA:
undetectable		 2f8dA-4xprA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 VAL A 171
SER A 137
LEU A  46
PHE A 159
 None
 1.20A 2f8dA-4zxlA:
undetectable		 2f8dA-4zxlA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		4 SER A 215
ARG A 243
LEU A 242
HIS A 244
 None
 1.31A 2f8dA-5c9lA:
undetectable		 2f8dA-5c9lA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzw PROTOCADHERIN
ALPHA-4

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 VAL A 166
SER A 150
ARG A 168
LEU A 119
 None
 1.22A 2f8dA-5dzwA:
undetectable		 2f8dA-5dzwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f17 NON-STRUCTURAL
PROTEIN 11

(Equine
arteritis virus) 		no annotation 4 VAL A  74
SER A 102
ARG A 104
PHE A 105
 None
 0.75A 2f8dA-5f17A:
undetectable		 2f8dA-5f17A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR TRANSFERASE
TTUA

(Thermus
thermophilus) 		PF01171
(ATP_bind_3) 		4 VAL A  12
SER A 208
LEU A  19
PHE A  30
 None
 1.10A 2f8dA-5ghaA:
undetectable		 2f8dA-5ghaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl4 RING-HYDROXYLATING
DIOXYGENASE

(Sinorhizobium
meliloti) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 VAL A  72
SER A  74
ARG A  80
LEU A 136
 None
 1.07A 2f8dA-5hl4A:
undetectable		 2f8dA-5hl4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 VAL A  36
SER A  40
LEU A 214
HIS A 286
 None
None
None
BAM  A 407 (-3.9A)
 1.23A 2f8dA-5jd4A:
undetectable		 2f8dA-5jd4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4s TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
2,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
1,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1

(Homo sapiens) 		no annotation 4 VAL A 119
SER A 118
ARG A  51
LEU A  48
 None
 1.34A 2f8dA-5m4sA:
undetectable		 2f8dA-5m4sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 VAL A 461
SER A 478
ARG A 453
LEU A 456
 None
 1.13A 2f8dA-5m85A:
undetectable		 2f8dA-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 VAL A 147
SER A 143
LEU A  63
PHE A 494
 None
 1.22A 2f8dA-5mrwA:
undetectable		 2f8dA-5mrwA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 VAL A 564
SER A 567
LEU A 546
HIS A 499
 None
None
None
FE2  A 901 (-3.6A)
 1.25A 2f8dA-5tr0A:
undetectable		 2f8dA-5tr0A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 VAL A 974
SER A 947
LEU A1012
HIS A 988
 None
 1.27A 2f8dA-5um6A:
0.6		 2f8dA-5um6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		4 VAL A3267
SER A3149
LEU A3135
PHE A3151
 None
 0.96A 2f8dA-5xauA:
undetectable		 2f8dA-5xauA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 4 VAL A  46
ARG A  58
LEU A  55
PHE A  73
 None
 1.32A 2f8dA-5xi0A:
undetectable		 2f8dA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 VAL A 436
SER A 440
LEU A 376
HIS A 299
 None
 1.31A 2f8dA-5xjjA:
undetectable		 2f8dA-5xjjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 VAL A1392
SER A1396
ARG A1426
LEU A1428
 None
 1.11A 2f8dA-5xsyA:
undetectable		 2f8dA-5xsyA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 4 SER A 364
ARG A 433
LEU A 436
HIS A 428
 None
 1.29A 2f8dA-5yb7A:
undetectable		 2f8dA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 VAL A 153
ARG A   7
LEU A  10
PHE A 148
 None
 1.35A 2f8dA-5ybbA:
undetectable		 2f8dA-5ybbA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emr -

(-) 		no annotation 4 VAL A 411
SER A 409
LEU A 377
PHE A 406
 None
 1.27A 2f8dA-6emrA:
undetectable		 2f8dA-6emrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 VAL A 746
SER A 728
ARG A 682
HIS A 679
 None
 1.03A 2f8dA-6ez8A:
undetectable		 2f8dA-6ez8A:
undetectable