SIMILAR PATTERNS OF AMINO ACIDS FOR 2F7F_A_NIOA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 PHE A 173
ARG A 186
GLY A 402
THR A 350
 None
 1.09A 2f7fA-1aorA:
undetectable		 2f7fA-1aorA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chm CREATINE
AMIDINOHYDROLASE

(Pseudomonas
putida) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 SER A 325
GLY A 327
THR A 328
ARG A 156
 None
 1.23A 2f7fA-1chmA:
undetectable		 2f7fA-1chmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cns CHITINASE

(Hordeum vulgare) 		PF00182
(Glyco_hydro_19) 		4 PHE A 218
ARG A 215
GLY A  83
THR A  69
 None
 1.07A 2f7fA-1cnsA:
undetectable		 2f7fA-1cnsA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		4 PHE B 460
SER A  47
GLY A 138
ARG A 143
 None
 1.00A 2f7fA-1cp9B:
undetectable		 2f7fA-1cp9B:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2e ELONGATION FACTOR TU
(EF-TU)

(Bos taurus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ARG A 411
SER A 296
GLY A 294
ARG A 335
 None
 1.25A 2f7fA-1d2eA:
2.4		 2f7fA-1d2eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis) 		PF00182
(Glyco_hydro_19) 		4 PHE A 217
ARG A 214
GLY A  84
THR A  70
 None
 1.12A 2f7fA-1dxjA:
undetectable		 2f7fA-1dxjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g13 GANGLIOSIDE M2
ACTIVATOR PROTEIN

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		4 SER A  42
GLY A 112
THR A 113
ARG A  18
 None
 1.21A 2f7fA-1g13A:
undetectable		 2f7fA-1g13A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		4 ARG A 161
GLY A 203
THR A 230
ARG A 195
 None
 1.20A 2f7fA-1gomA:
4.3		 2f7fA-1gomA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 623
GLY A 569
THR A 570
ARG A 505
 None
 1.25A 2f7fA-1itzA:
2.8		 2f7fA-1itzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 PHE A 281
SER A 272
GLY A 274
THR A 299
 None
AMP  A 706 (-4.7A)
None
None
 1.25A 2f7fA-1mb9A:
undetectable		 2f7fA-1mb9A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 PHE A 698
SER A 736
GLY A 583
THR A 582
 None
SO4  A 852 (-2.6A)
SO4  A 852 (-4.9A)
None
 1.19A 2f7fA-1nneA:
undetectable		 2f7fA-1nneA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		4 PHE A 134
SER A  35
GLY A  33
ARG A  31
 None
 1.20A 2f7fA-1nwaA:
2.1		 2f7fA-1nwaA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		4 SER A  43
GLY A  45
THR A  36
ARG A 119
 None
 1.25A 2f7fA-1nxuA:
undetectable		 2f7fA-1nxuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 148
SER A  40
GLY A  73
THR A  74
 None
 1.14A 2f7fA-1pl8A:
3.0		 2f7fA-1pl8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smp ERWINIA CHRYSANTHEMI
INHIBITOR

(Dickeya
chrysanthemi) 		PF02974
(Inh) 		4 PHE I  77
SER I  79
GLY I  64
THR I  61
 None
 1.23A 2f7fA-1smpI:
undetectable		 2f7fA-1smpI:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 354
ARG A 343
GLY A  41
THR A  42
 PHE  A 354 ( 1.3A)
ARG  A 343 ( 0.6A)
GLY  A  41 ( 0.0A)
THR  A  42 ( 0.8A)
 1.26A 2f7fA-1tedA:
undetectable		 2f7fA-1tedA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 PHE A 108
ARG A  89
GLY A 281
THR A 282
 None
 1.22A 2f7fA-1vefA:
undetectable		 2f7fA-1vefA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 ARG A 180
SER A 214
GLY A 228
THR A 229
ARG A 294
 None
 0.83A 2f7fA-1vlpA:
2.2		 2f7fA-1vlpA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PHE A 231
ARG A 197
GLY A 707
ARG A 287
 None
None
None
SO4  A3001 (-3.8A)
 1.23A 2f7fA-1xkwA:
undetectable		 2f7fA-1xkwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		5 PHE A 201
ARG A 204
SER A 231
GLY A 245
THR A 246
 None
 1.06A 2f7fA-1ybeA:
6.0		 2f7fA-1ybeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		5 PHE A 201
SER A 231
GLY A 245
THR A 246
ARG A 312
 None
 1.03A 2f7fA-1ybeA:
6.0		 2f7fA-1ybeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		6 PHE A 178
ARG A 181
SER A 208
GLY A 222
THR A 223
ARG A 287
 None
SO4  A2001 (-3.5A)
None
None
None
SO4  A2001 (-3.1A)
 0.61A 2f7fA-1yirA:
10.2		 2f7fA-1yirA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		6 PHE A 138
ARG A 141
SER A 164
GLY A 178
THR A 179
ARG A 235
 NCN  A 401 (-3.4A)
NCN  A 401 (-3.5A)
NCN  A 401 (-3.6A)
NCN  A 401 (-3.1A)
NCN  A 401 (-3.1A)
NCN  A 401 (-3.1A)
 0.63A 2f7fA-1ytkA:
33.9		 2f7fA-1ytkA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 ARG A  32
SER A  41
GLY A  44
THR A  45
 None
 1.25A 2f7fA-1yvpA:
2.6		 2f7fA-1yvpA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 PHE A  34
ARG A  31
SER A 105
GLY A 128
 None
 0.90A 2f7fA-1z7mA:
undetectable		 2f7fA-1z7mA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		4 PHE A 224
ARG A 227
GLY A 113
THR A 112
 None
 1.10A 2f7fA-1zmbA:
2.5		 2f7fA-1zmbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		6 PHE A 134
ARG A 137
SER A 160
GLY A 174
THR A 175
ARG A 233
 PCP  A 392 (-4.2A)
PCP  A 392 (-2.8A)
None
None
None
PCP  A 392 (-4.0A)
 0.83A 2f7fA-2i14A:
36.0		 2f7fA-2i14A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 ARG A 192
SER A 180
GLY A 248
THR A 249
 None
 1.21A 2f7fA-2i5gA:
3.1		 2f7fA-2i5gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		4 SER A 102
GLY A 104
THR A 105
ARG A   3
 None
 0.91A 2f7fA-2i99A:
2.2		 2f7fA-2i99A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		5 PHE A 165
ARG A 168
GLY A 209
THR A 210
ARG A 273
 None
 1.00A 2f7fA-2im5A:
10.6		 2f7fA-2im5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		4 PHE A 165
ARG A 168
SER A 195
THR A 210
 None
 1.09A 2f7fA-2im5A:
10.6		 2f7fA-2im5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 ARG A 629
SER A 454
GLY A 562
ARG A 440
 None
 1.20A 2f7fA-2jh9A:
undetectable		 2f7fA-2jh9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k23 LIPOCALIN 2

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 SER A 145
GLY A 143
THR A 141
ARG A 140
 None
 1.23A 2f7fA-2k23A:
undetectable		 2f7fA-2k23A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzt PROTEIN HRB1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 SER A 381
GLY A 417
THR A 416
ARG A 408
 None
 1.05A 2f7fA-2mztA:
undetectable		 2f7fA-2mztA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjs UNCHARACTERIZED
PROTEIN ATU1953

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		4 PHE A 101
ARG A 103
GLY A  56
THR A  60
 None
 1.05A 2f7fA-2pjsA:
undetectable		 2f7fA-2pjsA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 PHE A 355
ARG A 357
GLY A 282
THR A 351
 None
 0.95A 2f7fA-3a8kA:
undetectable		 2f7fA-3a8kA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 4 SER A 678
GLY A 683
THR A 684
ARG A 682
 None
 1.19A 2f7fA-3afbA:
2.3		 2f7fA-3afbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 PHE A 187
GLY A 330
THR A 406
ARG A 101
 None
 1.24A 2f7fA-3aivA:
3.4		 2f7fA-3aivA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 ARG A 197
GLY A 156
THR A 176
ARG A  92
 NRQ  A  63 ( 3.9A)
None
None
NRQ  A  63 ( 2.6A)
 1.08A 2f7fA-3bxaA:
undetectable		 2f7fA-3bxaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya) 		PF00182
(Glyco_hydro_19) 		4 PHE A 218
ARG A 215
GLY A  83
THR A  69
 None
NDG  A 244 (-4.4A)
None
None
 1.15A 2f7fA-3cqlA:
undetectable		 2f7fA-3cqlA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 ARG A 333
SER A  43
GLY A  15
THR A  16
 None
FAD  A 500 (-2.9A)
FAD  A 500 (-3.2A)
FAD  A 500 (-3.2A)
 1.22A 2f7fA-3djdA:
undetectable		 2f7fA-3djdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmy HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA
(YGIT/B3021)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		4 PHE A  99
ARG A 101
SER A  89
THR A 113
 None
 1.24A 2f7fA-3fmyA:
undetectable		 2f7fA-3fmyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 SER A 186
GLY A 263
THR A 262
ARG A 199
 None
 1.18A 2f7fA-3gvcA:
undetectable		 2f7fA-3gvcA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 ARG A 498
SER A  84
GLY A 129
THR A 110
 None
 1.04A 2f7fA-3koyA:
4.3		 2f7fA-3koyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l60 BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00198
(2-oxoacid_dh) 		4 PHE A 314
SER A 312
GLY A 335
THR A 359
 UNL  A   1 ( 4.5A)
UNL  A   1 ( 3.6A)
None
None
 0.97A 2f7fA-3l60A:
undetectable		 2f7fA-3l60A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 ARG A 588
SER A 458
GLY A 460
THR A 453
 None
 1.18A 2f7fA-3mc2A:
undetectable		 2f7fA-3mc2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		5 PHE A 174
ARG A 177
SER A 203
GLY A 217
ARG A 282
 None
None
None
GOL  A 411 (-3.3A)
None
 0.46A 2f7fA-3os4A:
6.9		 2f7fA-3os4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 PHE A 174
SER A 203
GLY A 217
THR A 218
 None
None
GOL  A 411 (-3.3A)
FMT  A 414 (-2.8A)
 1.02A 2f7fA-3os4A:
6.9		 2f7fA-3os4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ARG A 280
SER A 274
GLY A 395
THR A 396
 None
 1.14A 2f7fA-3oytA:
undetectable		 2f7fA-3oytA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 SER A 410
GLY A 376
THR A 375
ARG A 402
 None
 1.02A 2f7fA-3p11A:
undetectable		 2f7fA-3p11A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE

(Ovis aries) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 147
SER A  39
GLY A  72
THR A  73
 None
 1.12A 2f7fA-3qe3A:
3.8		 2f7fA-3qe3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 PHE A 107
GLY A  48
THR A  50
ARG A  89
 None
 0.97A 2f7fA-3rd7A:
undetectable		 2f7fA-3rd7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh8 VIVID PAS PROTEIN
VVD

(Neurospora
crassa) 		PF13426
(PAS_9) 		4 ARG B 106
SER B  99
GLY B  97
THR B  96
 None
 1.08A 2f7fA-3rh8B:
undetectable		 2f7fA-3rh8B:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		4 ARG A 137
SER A 223
GLY A 225
THR A 217
 None
 1.16A 2f7fA-3rjuA:
undetectable		 2f7fA-3rjuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		4 ARG A  30
GLY A 226
THR A   9
ARG A 162
 NRQ  A 133 ( 3.8A)
None
None
NRQ  A 133 ( 2.7A)
 1.00A 2f7fA-3rwaA:
undetectable		 2f7fA-3rwaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ARG A 152
SER A 158
GLY A 217
THR A 218
 None
 0.97A 2f7fA-3t6sA:
undetectable		 2f7fA-3t6sA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ARG A 277
SER A 271
GLY A 395
THR A 396
 None
 1.15A 2f7fA-3u0fA:
undetectable		 2f7fA-3u0fA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 831
SER A 840
GLY A 842
ARG A 636
 None
 1.15A 2f7fA-3zifA:
undetectable		 2f7fA-3zifA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 PHE A 752
ARG A 347
GLY A 670
ARG A 827
 None
 1.20A 2f7fA-3zifA:
undetectable		 2f7fA-3zifA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		4 PHE A   5
ARG A  39
GLY A  16
THR A  17
 None
 1.19A 2f7fA-3zs3A:
undetectable		 2f7fA-3zs3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae) 		PF07571
(TAF6_C) 		4 PHE A 216
SER A 259
GLY A 257
THR A 253
 None
None
None
NHE  A 401 (-4.2A)
 1.24A 2f7fA-4atgA:
undetectable		 2f7fA-4atgA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 PHE A 498
SER A 533
GLY A 650
THR A 651
 None
 1.02A 2f7fA-4ccdA:
3.3		 2f7fA-4ccdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PHE A 303
ARG A 448
GLY A 467
THR A 454
 None
 1.03A 2f7fA-4cotA:
undetectable		 2f7fA-4cotA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 SER A 448
GLY A 710
THR A 711
ARG A 468
 None
 1.17A 2f7fA-4cu8A:
3.7		 2f7fA-4cu8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		5 ARG A 187
SER A 214
GLY A 228
THR A 229
ARG A 292
 None
 0.72A 2f7fA-4hl7A:
9.2		 2f7fA-4hl7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 PHE A 123
ARG A 124
GLY A  28
THR A 276
 None
 1.10A 2f7fA-4hpvA:
undetectable		 2f7fA-4hpvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		4 ARG A 196
GLY A 154
THR A 174
ARG A  89
 CR2  A  58 ( 3.9A)
None
None
CR2  A  58 ( 2.7A)
 1.16A 2f7fA-4jgeA:
undetectable		 2f7fA-4jgeA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT

(Homo sapiens) 		PF01896
(DNA_primase_S) 		4 SER A 351
GLY A 328
THR A 327
ARG A 329
 None
 1.18A 2f7fA-4likA:
undetectable		 2f7fA-4likA:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Enterococcus
faecalis) 		PF04095
(NAPRTase) 		4 ARG A 163
SER A 187
GLY A 201
ARG A 262
 CL  A 518 (-4.1A)
None
CL  A 521 (-3.8A)
FMT  A 520 (-3.1A)
 0.65A 2f7fA-4mzyA:
59.0		 2f7fA-4mzyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 PHE A 483
SER A 331
GLY A 335
THR A 336
 None
 1.15A 2f7fA-4oe5A:
2.7		 2f7fA-4oe5A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 PHE A 235
ARG A 240
GLY A 276
THR A 278
 None
 1.15A 2f7fA-4ptsA:
undetectable		 2f7fA-4ptsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 PHE A 140
SER A 122
GLY A 126
ARG A 136
 None
 1.23A 2f7fA-4q65A:
undetectable		 2f7fA-4q65A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF13426
(PAS_9) 		4 ARG A  53
SER A  46
GLY A  44
THR A  43
 None
 1.08A 2f7fA-4r38A:
undetectable		 2f7fA-4r38A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		4 ARG A 134
GLY A 130
THR A 129
ARG A 100
 None
 1.12A 2f7fA-4rnsA:
undetectable		 2f7fA-4rnsA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen K88 FIMBRIAL PROTEIN
AC

(Escherichia
coli) 		PF02432
(Fimbrial_K88) 		4 SER A 142
GLY A 139
THR A 221
ARG A 137
 None
 1.07A 2f7fA-4wenA:
undetectable		 2f7fA-4wenA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ARG A 277
SER A 271
GLY A 391
THR A 392
 None
 1.13A 2f7fA-4xoxA:
undetectable		 2f7fA-4xoxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqv CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		PF07262
(CdiI) 		4 PHE A  73
SER A  69
GLY A  26
ARG A  31
 None
 1.20A 2f7fA-4zqvA:
undetectable		 2f7fA-4zqvA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bql FLUORESCENT PROTEIN
CYOFP

(Escherichia
coli) 		PF01353
(GFP) 		4 ARG A 201
GLY A 160
THR A 180
ARG A  96
 NRQ  A  67 ( 3.8A)
None
None
NRQ  A  67 ( 2.5A)
 1.03A 2f7fA-5bqlA:
undetectable		 2f7fA-5bqlA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 4 ARG A 137
GLY A 398
THR A 397
ARG A 399
 None
 1.06A 2f7fA-5efvA:
undetectable		 2f7fA-5efvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 388
SER A 377
GLY A 409
THR A 408
 None
 1.19A 2f7fA-5fokA:
undetectable		 2f7fA-5fokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 678
GLY A 660
THR A 627
ARG A  48
 None
 0.97A 2f7fA-5fp2A:
undetectable		 2f7fA-5fp2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 PHE A 425
SER A  37
GLY A  45
THR A  44
 None
 1.19A 2f7fA-5h2tA:
3.1		 2f7fA-5h2tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm6 AMINOPEPTIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF02127
(Peptidase_M18) 		4 PHE A 353
ARG A 346
SER A 111
THR A 105
 None
 0.89A 2f7fA-5jm6A:
undetectable		 2f7fA-5jm6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk4 MSCARLET

(Discosoma sp.) 		PF01353
(GFP) 		4 ARG A 198
GLY A 160
THR A 180
ARG A  96
 NRQ  A  67 ( 4.3A)
None
None
NRQ  A  67 ( 3.0A)
 1.03A 2f7fA-5lk4A:
undetectable		 2f7fA-5lk4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		4 SER A 330
GLY A 334
THR A 335
ARG A 356
 None
 1.22A 2f7fA-5m95A:
undetectable		 2f7fA-5m95A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 SER A 394
GLY A 401
THR A 403
ARG A 198
 None
 1.17A 2f7fA-5nd1A:
undetectable		 2f7fA-5nd1A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 663
GLY A 609
THR A 610
ARG A 545
 None
 1.22A 2f7fA-5nd5A:
2.6		 2f7fA-5nd5A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ARG A 206
SER A 172
GLY A 118
THR A 117
 None
None
None
73R  A1201 (-3.3A)
 1.24A 2f7fA-5t1aA:
undetectable		 2f7fA-5t1aA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9t PROTOCADHERIN GAMMA
B2-ALPHA C

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 SER A 453
GLY A 508
THR A 511
ARG A 505
 None
 1.16A 2f7fA-5t9tA:
undetectable		 2f7fA-5t9tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 4 SER B 220
GLY B 213
THR B 212
ARG B 159
 None
 1.03A 2f7fA-5u7zB:
undetectable		 2f7fA-5u7zB:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 4 SER A 220
GLY A 213
THR A 212
ARG A 159
 None
 0.97A 2f7fA-5u81A:
undetectable		 2f7fA-5u81A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 PHE A 553
SER A 454
GLY A 458
THR A 459
 None
 1.05A 2f7fA-5uv2A:
undetectable		 2f7fA-5uv2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 PHE A1858
ARG A1822
GLY A1778
THR A1777
 None
 1.22A 2f7fA-5xbfA:
undetectable		 2f7fA-5xbfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgw ISOASPARTYL
DIPEPTIDASE

(Colwellia
psychrerythraea) 		no annotation 4 ARG A 237
GLY A 108
THR A 109
ARG A 173
 None
 1.20A 2f7fA-5xgwA:
3.9		 2f7fA-5xgwA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 PHE C3887
ARG C2891
SER C3891
ARG C3901
 None
 1.16A 2f7fA-5y3rC:
undetectable		 2f7fA-5y3rC:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 PHE A 550
ARG A 566
GLY A 116
ARG A 659
 None
None
None
GOL  A 803 (-4.1A)
 1.20A 2f7fA-5yfbA:
undetectable		 2f7fA-5yfbA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 PHE A 346
SER A 222
GLY A 220
THR A  28
 None
 1.21A 2f7fA-5yptA:
undetectable		 2f7fA-5yptA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 SER A 193
GLY A 220
THR A 236
ARG A 243
 None
 0.89A 2f7fA-5zqeA:
undetectable		 2f7fA-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE3 FAMILY

(Thermobifida
fusca) 		no annotation 4 SER O 180
GLY O  24
THR O  22
ARG O 172
 G  J  61 ( 3.1A)
None
None
None
 1.23A 2f7fA-6c66O:
undetectable		 2f7fA-6c66O:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 ARG A 100
GLY B 192
THR B 193
ARG B 190
 None
 1.08A 2f7fA-6cxhA:
undetectable		 2f7fA-6cxhA:
9.82