SIMILAR PATTERNS OF AMINO ACIDS FOR 2F7A_B_BEZB1002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 5 LEU A 137
LEU A 138
ILE A 117
LEU A 335
ILE A  17
 None
 1.21A 2f7aB-1bwdA:
undetectable		 2f7aB-1bwdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 209
LEU A 212
ILE A  98
LEU A  22
ILE A  25
 None
 1.21A 2f7aB-1g7rA:
undetectable		 2f7aB-1g7rA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 170
LEU A 171
ILE A 177
LEU A  94
ILE A  97
 None
 1.05A 2f7aB-1gsqA:
1.3		 2f7aB-1gsqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgn POLYADENYLATE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00658
(PABP) 		5 LEU A  47
LEU A  48
ILE A  50
LEU A  31
ILE A  32
 None
 0.91A 2f7aB-1jgnA:
undetectable		 2f7aB-1jgnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU B 330
LEU B 329
ILE B 326
LEU B 406
ILE B 403
 None
 1.00A 2f7aB-1m2vB:
2.4		 2f7aB-1m2vB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 LEU A 238
LEU A 196
ILE A 200
PHE A 232
ILE A 185
 None
 1.25A 2f7aB-1mkyA:
1.4		 2f7aB-1mkyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A  69
LEU A  68
LEU A 234
LEU A 142
ILE A 144
 None
 1.18A 2f7aB-1vkoA:
0.9		 2f7aB-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.04A 2f7aB-1vkoA:
0.9		 2f7aB-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7p VPS22, YPL002C

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		5 LEU A 119
LEU A 134
ILE A 138
PHE A 116
ILE A 114
 None
 1.23A 2f7aB-1w7pA:
undetectable		 2f7aB-1w7pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		5 LEU A 278
LEU A 280
LEU A 281
PHE A 257
TYR A 142
 None
 1.23A 2f7aB-1xnfA:
undetectable		 2f7aB-1xnfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 5 LEU B 338
LEU B 257
ILE B 259
PHE B 281
ILE B 377
 None
 1.07A 2f7aB-1xnjB:
1.0		 2f7aB-1xnjB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9i INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-4

(Mus musculus) 		no annotation 5 LEU A  70
LEU A  71
ILE A  11
ARG A  47
ILE A  39
 None
 1.22A 2f7aB-2a9iA:
undetectable		 2f7aB-2a9iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		5 LEU A 119
LEU A 135
ILE A 133
LEU A  88
ILE A  90
 None
 1.23A 2f7aB-2amlA:
1.2		 2f7aB-2amlA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8m HYPOTHETICAL PROTEIN
MJ0764

(Methanocaldococcus
jannaschii) 		PF00190
(Cupin_1) 		5 LEU A  93
LEU A  33
ILE A  31
LEU A  50
ILE A  52
 None
 1.20A 2f7aB-2b8mA:
undetectable		 2f7aB-2b8mA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cr5 REPRODUCTION 8

(Mus musculus) 		PF00789
(UBX) 		5 LEU A  93
LEU A  74
LEU A  65
LEU A  82
ILE A  87
 None
 1.21A 2f7aB-2cr5A:
undetectable		 2f7aB-2cr5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqx KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07707
(BACK) 		5 LEU A 206
LEU A 207
ILE A 210
PHE A 199
LEU A 164
 None
 1.18A 2f7aB-2eqxA:
undetectable		 2f7aB-2eqxA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 None
 0.57A 2f7aB-2f6gA:
32.1		 2f7aB-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		6 LEU A   3
LEU A  57
ILE A  63
LEU A 101
ARG A 100
ILE A   5
 None
 1.16A 2f7aB-2fe7A:
undetectable		 2f7aB-2fe7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		5 LEU A 159
ILE A 145
PHE A 184
LEU A 192
TYR A 481
 None
 1.19A 2f7aB-2h1nA:
undetectable		 2f7aB-2h1nA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		6 LEU A 100
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.83A 2f7aB-2h98A:
30.5		 2f7aB-2h98A:
41.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		6 LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.79A 2f7aB-2h98A:
30.5		 2f7aB-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LEU A 386
LEU A 340
ILE A 337
PHE A 389
LEU A 409
 None
 1.13A 2f7aB-2j5cA:
undetectable		 2f7aB-2j5cA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE

(Bacillus
licheniformis) 		PF00583
(Acetyltransf_1) 		5 LEU A  42
ILE A  91
PHE A  56
LEU A  98
ILE A  97
 None
 1.17A 2f7aB-2jdcA:
undetectable		 2f7aB-2jdcA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khe TOXIN-LIKE PROTEIN

(Thermus
thermophilus) 		PF05016
(ParE_toxin) 		6 LEU A  47
LEU A  52
PHE A  55
LEU A  79
ARG A  80
ILE A  66
 None
 1.33A 2f7aB-2kheA:
undetectable		 2f7aB-2kheA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		5 LEU A 110
LEU A 111
LEU A 124
LEU A  80
ILE A  82
 None
 1.01A 2f7aB-2knqA:
undetectable		 2f7aB-2knqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krt CONSERVED
HYPOTHETICAL
MEMBRANE LIPOPROTEIN

(Ureaplasma
parvum) 		PF04200
(Lipoprotein_17) 		5 LEU A  26
ILE A  42
PHE A  24
LEU A  86
ILE A  65
 None
 0.96A 2f7aB-2krtA:
undetectable		 2f7aB-2krtA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 LEU A 239
LEU A 238
LEU A 354
ILE A 352
ILE A 275
 None
 1.12A 2f7aB-2odpA:
2.0		 2f7aB-2odpA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		5 LEU A 100
LEU A 146
LEU A 148
LEU A 141
ILE A 103
 None
 0.90A 2f7aB-2p91A:
undetectable		 2f7aB-2p91A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 LEU A  35
LEU A  34
LEU A  40
PHE A 106
LEU A  59
 None
 1.25A 2f7aB-2r98A:
undetectable		 2f7aB-2r98A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc5 FERREDOXIN-NADP
REDUCTASE

(Leptospira
interrogans) 		PF00175
(NAD_binding_1) 		5 LEU A 309
LEU A 303
PHE A 269
LEU A 171
ILE A 271
 None
 1.25A 2f7aB-2rc5A:
undetectable		 2f7aB-2rc5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 522
LEU A 525
ILE A 528
PHE A 519
LEU A 492
 None
 1.20A 2f7aB-2z7xA:
undetectable		 2f7aB-2z7xA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 154
LEU A 179
ILE A 181
PHE A 170
LEU A 139
 None
 1.20A 2f7aB-2z80A:
undetectable		 2f7aB-2z80A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 154
LEU A 179
ILE A 181
PHE A 170
LEU A 139
 None
 1.23A 2f7aB-2z81A:
undetectable		 2f7aB-2z81A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU X 769
LEU X 795
ILE X 793
ARG X 762
ILE X 764
 None
 1.10A 2f7aB-2zkmX:
undetectable		 2f7aB-2zkmX:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.24A 2f7aB-3abbA:
undetectable		 2f7aB-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.03A 2f7aB-3b3jA:
undetectable		 2f7aB-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.77A 2f7aB-3bg0B:
undetectable		 2f7aB-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct4 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Lactococcus
lactis) 		PF02733
(Dak1) 		5 LEU A 313
LEU A 319
PHE A 291
LEU A 157
ILE A 311
 None
 0.98A 2f7aB-3ct4A:
undetectable		 2f7aB-3ct4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		5 LEU A 194
LEU A 195
ILE A 169
LEU A 184
ILE A 188
 None
 1.24A 2f7aB-3en0A:
undetectable		 2f7aB-3en0A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 LEU A 189
ILE A 194
LEU A 171
ILE A 174
TYR A 168
 None
None
SO4  A 362 (-4.1A)
None
SO4  A 362 (-4.5A)
 1.23A 2f7aB-3ffhA:
undetectable		 2f7aB-3ffhA:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		7 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 GOL  A   2 (-4.3A)
GOL  A   2 (-3.7A)
None
None
None
None
GOL  A   2 (-4.9A)
 0.69A 2f7aB-3glbA:
31.9		 2f7aB-3glbA:
54.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv5 DNA POLYMERASE IOTA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 LEU B 344
LEU B 390
ILE B 386
LEU B 325
ILE B 321
 None
 1.21A 2f7aB-3gv5B:
undetectable		 2f7aB-3gv5B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.14A 2f7aB-3ho8A:
undetectable		 2f7aB-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		5 LEU A 109
LEU A 106
PHE A  81
LEU A  55
ILE A   6
 None
 1.09A 2f7aB-3ib6A:
undetectable		 2f7aB-3ib6A:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		8 LEU A 100
LEU A 104
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 IMD  A 313 ( 4.1A)
CL  A 314 ( 4.1A)
None
IMD  A 313 ( 4.9A)
None
CL  A 314 (-3.4A)
IMD  A 313 ( 4.1A)
IMD  A 313 (-4.7A)
 0.72A 2f7aB-3k1nA:
32.4		 2f7aB-3k1nA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		8 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
TYR A 293
 IMD  A 313 ( 4.1A)
CL  A 314 ( 4.1A)
IMD  A 313 ( 4.0A)
None
IMD  A 313 ( 4.9A)
None
IMD  A 313 ( 4.1A)
IMD  A 313 (-4.7A)
 0.69A 2f7aB-3k1nA:
32.4		 2f7aB-3k1nA:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		5 LEU A 559
LEU A 560
ILE A 641
LEU A 582
ILE A 607
 None
 1.24A 2f7aB-3la6A:
undetectable		 2f7aB-3la6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.26A 2f7aB-3o75A:
3.0		 2f7aB-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c ABL INTERACTOR 2

(Homo sapiens) 		PF07815
(Abi_HHR) 		5 LEU F   4
LEU F   7
LEU F   8
ILE F  12
LEU F  76
 None
 1.22A 2f7aB-3p8cF:
undetectable		 2f7aB-3p8cF:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 118
LEU A 119
LEU A 181
ILE A 186
TYR A 180
 None
 1.22A 2f7aB-3q5iA:
undetectable		 2f7aB-3q5iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445

(Oleispira
antarctica) 		PF03009
(GDPD) 		5 LEU A 113
LEU A 146
LEU A 145
ILE A 165
LEU A 117
 None
 1.21A 2f7aB-3qvqA:
undetectable		 2f7aB-3qvqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 LEU A  53
LEU A  50
LEU A 345
ARG A 343
ILE A 335
 None
 1.09A 2f7aB-3r75A:
undetectable		 2f7aB-3r75A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 5 LEU A  50
ILE A  48
PHE A  58
LEU A 211
ILE A  39
 None
 1.19A 2f7aB-3s4lA:
undetectable		 2f7aB-3s4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 LEU A   4
LEU A  37
ILE A  39
LEU A 178
ILE A 176
 None
 1.14A 2f7aB-3t7bA:
undetectable		 2f7aB-3t7bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ups IOJAP-LIKE PROTEIN

(Zymomonas
mobilis) 		PF02410
(RsfS) 		5 LEU A  22
LEU A  20
LEU A  19
ILE A  98
LEU A  27
 None
 1.20A 2f7aB-3upsA:
undetectable		 2f7aB-3upsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 751
ILE A 771
PHE A 703
LEU A 668
ILE A 686
 None
 1.23A 2f7aB-3va6A:
undetectable		 2f7aB-3va6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 598
LEU A 601
LEU A 565
ILE A 561
ILE A 476
 None
 1.25A 2f7aB-4a2pA:
undetectable		 2f7aB-4a2pA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 607
LEU A 608
PHE A 711
LEU A 683
TYR A 682
 None
 1.19A 2f7aB-4at3A:
undetectable		 2f7aB-4at3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		5 LEU A 177
LEU A  92
PHE A 193
LEU A 161
ILE A 157
 None
 1.17A 2f7aB-4fe2A:
undetectable		 2f7aB-4fe2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 LEU A 152
LEU A 149
ILE A 249
LEU A 302
ILE A 310
 None
 1.17A 2f7aB-4fl0A:
undetectable		 2f7aB-4fl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 LEU A 223
LEU A 219
LEU A 221
ILE A 217
ILE A 209
 None
 1.24A 2f7aB-4g3jA:
undetectable		 2f7aB-4g3jA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		5 LEU A 259
LEU A 267
PHE A 255
LEU A 109
ILE A 281
 None
 1.12A 2f7aB-4jnqA:
undetectable		 2f7aB-4jnqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 LEU A 186
PHE A 162
LEU A   4
ARG A   5
ILE A   8
 None
 1.22A 2f7aB-4jo0A:
undetectable		 2f7aB-4jo0A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE

(Sulfurimonas
denitrificans) 		PF01048
(PNP_UDP_1) 		5 LEU A  72
ILE A 221
PHE A 189
ARG A 192
ILE A 190
 None
 1.04A 2f7aB-4jwtA:
undetectable		 2f7aB-4jwtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		5 LEU A  27
LEU A  30
ILE A  25
PHE A  77
LEU A  66
 None
 1.21A 2f7aB-4jylA:
undetectable		 2f7aB-4jylA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 LEU B 316
LEU B 336
LEU B 337
ILE B 342
LEU B 320
 None
 1.06A 2f7aB-4kvgB:
undetectable		 2f7aB-4kvgB:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		5 LEU A  31
LEU A  32
LEU A  28
LEU A  77
ILE A  43
 None
 1.12A 2f7aB-4m0vA:
undetectable		 2f7aB-4m0vA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Bacteroides
uniformis) 		PF16255
(Lipase_GDSL_lke) 		5 LEU A 156
LEU A 157
ILE A 169
ILE A 109
TYR A 164
 None
 1.24A 2f7aB-4m8kA:
undetectable		 2f7aB-4m8kA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 324
LEU A 300
ILE A 295
LEU A 308
ILE A 304
 None
 1.24A 2f7aB-4mn8A:
undetectable		 2f7aB-4mn8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pg6 HOMOSERINE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A   9
LEU A   8
LEU A  43
LEU A  73
ILE A  76
 None
 1.05A 2f7aB-4pg6A:
undetectable		 2f7aB-4pg6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF08759
(GT-D) 		5 LEU A 195
LEU A 143
ILE A 145
LEU A 221
ILE A 219
 None
 1.20A 2f7aB-4phsA:
undetectable		 2f7aB-4phsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		5 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.88A 2f7aB-4q3lA:
undetectable		 2f7aB-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 434
LEU A 432
PHE A 523
LEU A 495
ILE A 500
 None
 1.22A 2f7aB-4q9zA:
undetectable		 2f7aB-4q9zA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa RAS-RELATED PROTEIN
RAB-9A

(Mus musculus) 		PF00071
(Ras) 		5 LEU A  85
LEU A  84
LEU A  13
ILE A  11
PHE A 105
 None
 1.21A 2f7aB-4qxaA:
undetectable		 2f7aB-4qxaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ua3 UNCHARACTERIZED
N-ACETYLTRANSFERASE
C825.04C

(Schizosaccharomyces
pombe) 		PF00583
(Acetyltransf_1) 		5 LEU A 102
LEU A 136
LEU A 135
ILE A 117
TYR A 166
 None
 1.05A 2f7aB-4ua3A:
1.9		 2f7aB-4ua3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 236
LEU A 256
ILE A 253
PHE A 230
LEU A 241
 None
 1.15A 2f7aB-4ufsA:
undetectable		 2f7aB-4ufsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 LEU A 550
LEU A 547
ILE A 261
LEU A 243
ILE A 553
 None
 0.93A 2f7aB-4x1zA:
undetectable		 2f7aB-4x1zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		5 LEU A 254
LEU A 251
ILE A 293
PHE A 271
ILE A 318
 None
 1.25A 2f7aB-4zmiA:
undetectable		 2f7aB-4zmiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 620
LEU A 680
ILE A 700
LEU A 599
ILE A 602
 None
 1.19A 2f7aB-5a0zA:
undetectable		 2f7aB-5a0zA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 280
LEU A 215
ILE A 217
LEU A 328
ILE A 307
 None
None
None
FAD  A 701 (-3.8A)
None
 1.16A 2f7aB-5ahkA:
2.1		 2f7aB-5ahkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 LEU B 378
LEU B 375
ILE B 348
PHE B 371
LEU B 328
 None
 1.20A 2f7aB-5dlqB:
undetectable		 2f7aB-5dlqB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.15A 2f7aB-5eioA:
undetectable		 2f7aB-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esp I-PANMI

(Podospora
anserina) 		PF00961
(LAGLIDADG_1) 		5 LEU A 126
LEU A 127
ILE A 151
LEU A 144
ILE A  27
 None
 1.17A 2f7aB-5espA:
undetectable		 2f7aB-5espA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A

(Staphylococcus
aureus;
Bacillus sp.
HIL-Y85/54728) 		PF02216
(B)
PF02441
(Flavoprotein) 		5 LEU A  28
ILE A  88
PHE A  31
LEU A  11
ILE A  38
 None
 1.23A 2f7aB-5h75A:
undetectable		 2f7aB-5h75A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 LEU A 196
LEU A 227
LEU A 193
PHE A 155
LEU A 208
 None
 1.20A 2f7aB-5it1A:
undetectable		 2f7aB-5it1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 840
LEU A 838
PHE A 875
LEU A 859
ILE A 862
 None
 1.19A 2f7aB-5j6sA:
undetectable		 2f7aB-5j6sA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joq LMO2184 PROTEIN

(Listeria
monocytogenes) 		PF01497
(Peripla_BP_2) 		5 LEU A  53
LEU A  51
ILE A  47
LEU A  95
ILE A  37
 None
 1.14A 2f7aB-5joqA:
undetectable		 2f7aB-5joqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 317
LEU A 319
LEU A 320
ILE A 305
TYR A 273
 None
 1.24A 2f7aB-5kf7A:
2.0		 2f7aB-5kf7A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldk RNA 2',3'-CYCLIC
PHOSPHODIESTERASE

(Escherichia
coli) 		PF02834
(LigT_PEase) 		5 LEU A  46
LEU A 106
ILE A  67
PHE A 152
LEU A 174
 None
 1.23A 2f7aB-5ldkA:
undetectable		 2f7aB-5ldkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU B 367
LEU B 527
ILE B 529
LEU B 545
ILE B 543
 None
 1.19A 2f7aB-5mkkB:
undetectable		 2f7aB-5mkkB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 LEU A 501
LEU A 148
ILE A 502
PHE A 373
LEU A 360
 None
 1.21A 2f7aB-5mz9A:
undetectable		 2f7aB-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 728
PHE A 823
LEU A 794
ILE A 799
TYR A 793
 None
 1.14A 2f7aB-5vilA:
undetectable		 2f7aB-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 5 LEU M  36
LEU M 125
ILE M 127
LEU M  65
ILE M  63
 None
 1.13A 2f7aB-5wc8M:
undetectable		 2f7aB-5wc8M:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 LEU A  60
LEU A  81
ILE A  79
LEU A 120
ILE A 123
 None
 1.15A 2f7aB-5wp4A:
undetectable		 2f7aB-5wp4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 5 LEU B 321
LEU B 317
LEU B 310
ARG B 311
ILE B 303
 None
 1.16A 2f7aB-5xguB:
undetectable		 2f7aB-5xguB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 415
LEU A 416
ILE A 419
PHE A 326
LEU A 377
 None
 1.13A 2f7aB-5zb3A:
undetectable		 2f7aB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 5 LEU A 272
ILE A 207
PHE A 265
LEU A 245
ILE A 285
 None
 1.16A 2f7aB-6b2wA:
undetectable		 2f7aB-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4e NUCLEOPORIN GLE1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 296
LEU B 353
PHE B 293
LEU B 310
ILE B 306
 None
 1.23A 2f7aB-6b4eB:
undetectable		 2f7aB-6b4eB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 5 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.86A 2f7aB-6d2lA:
undetectable		 2f7aB-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 ILE D 137
PHE D  95
LEU D  67
ARG D  68
ILE D  64
 None
 1.17A 2f7aB-6f45D:
undetectable		 2f7aB-6f45D:
undetectable