SIMILAR PATTERNS OF AMINO ACIDS FOR 2F7A_B_ACTB1004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		4 HIS A 154
PRO A 155
ASN A 159
TYR A 150
 None
 1.35A 2f7aB-1e09A:
0.0		 2f7aB-1e09A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 HIS A  15
PRO A 201
ASN A  11
TYR A  16
 None
None
None
SAH  A1900 ( 4.2A)
 1.48A 2f7aB-1kphA:
0.0		 2f7aB-1kphA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 HIS A 180
PRO A 117
ASN A 116
TYR A 183
 EDO  A 602 ( 4.8A)
None
None
None
 1.47A 2f7aB-2czqA:
2.2		 2f7aB-2czqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 HIS A 525
PRO A 585
ASN A 584
TYR A 523
 None
 1.41A 2f7aB-2d0vA:
0.0		 2f7aB-2d0vA:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		4 HIS A 116
PRO A 117
ASN A 118
TYR A 281
 None
 0.77A 2f7aB-2f6gA:
32.1		 2f7aB-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 HIS A 410
PRO A 407
ASN A 406
TYR A 390
 3ES  A1635 (-3.4A)
CL  A1627 ( 4.6A)
None
None
 1.21A 2f7aB-2xy9A:
undetectable		 2f7aB-2xy9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 HIS A 388
PRO A 385
ASN A 384
TYR A 368
 3ES  A1611 (-3.6A)
CL  A1621 ( 4.5A)
None
None
 1.19A 2f7aB-2xydA:
0.0		 2f7aB-2xydA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znm THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		4 HIS A  39
PRO A  89
ASN A  88
TYR A  96
 None
 1.20A 2f7aB-2znmA:
0.2		 2f7aB-2znmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 HIS A 368
PRO A 331
ASN A 330
TYR A 364
 None
 1.37A 2f7aB-3hkaA:
0.0		 2f7aB-3hkaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Sinorhizobium
meliloti) 		PF03466
(LysR_substrate) 		4 HIS A 169
PRO A 170
ASN A 181
TYR A 183
 None
 1.18A 2f7aB-3mz1A:
12.6		 2f7aB-3mz1A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4l ION TRANSPORT
PROTEIN

(Magnetococcus
marinus) 		PF00520
(Ion_trans) 		4 HIS A  67
PRO A  68
ASN A  69
TYR A  28
 None
 1.01A 2f7aB-4f4lA:
undetectable		 2f7aB-4f4lA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 HIS A 149
PRO A 150
ASN A 151
TYR A  75
 None
 1.21A 2f7aB-4gpgA:
undetectable		 2f7aB-4gpgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		4 HIS A 243
PRO A 242
ASN A 244
TYR A 208
 None
 1.15A 2f7aB-4mupA:
undetectable		 2f7aB-4mupA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2z ION TRANSPORT
PROTEIN

(Magnetococcus
marinus) 		PF00520
(Ion_trans) 		4 HIS A 192
PRO A 193
ASN A 194
TYR A 153
 12P  A 301 (-4.0A)
12P  A 301 (-4.4A)
12P  A 301 (-4.6A)
12P  A 301 (-4.6A)
 0.82A 2f7aB-4p2zA:
undetectable		 2f7aB-4p2zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		4 HIS A 188
PRO A 189
ASN A 190
TYR A 248
 None
 0.82A 2f7aB-4zk6A:
undetectable		 2f7aB-4zk6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 HIS A 394
PRO A 391
ASN A 390
TYR A 374
 None
TRS  A7002 ( 4.9A)
None
None
 1.18A 2f7aB-5a2rA:
undetectable		 2f7aB-5a2rA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvd ION TRANSPORT
PROTEIN

(Magnetococcus
marinus) 		PF00520
(Ion_trans) 		4 HIS A 192
PRO A 193
ASN A 194
TYR A 153
 12P  A 305 (-4.2A)
12P  A 305 (-3.8A)
2CV  A 304 ( 4.2A)
12P  A 305 (-4.8A)
 0.91A 2f7aB-5hvdA:
undetectable		 2f7aB-5hvdA:
21.20