SIMILAR PATTERNS OF AMINO ACIDS FOR 2F7A_A_BEZA1003_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 5 LEU A 137
LEU A 138
ILE A 117
LEU A 335
ILE A  17
 None
 1.16A 2f7aA-1bwdA:
undetectable		 2f7aA-1bwdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		5 LEU A 190
LEU A 194
ILE A 197
ILE A 173
TYR A 155
 None
 1.18A 2f7aA-1f76A:
undetectable		 2f7aA-1f76A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fio SSO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin) 		5 LEU A 213
LEU A  94
ILE A  98
LEU A 123
ILE A 126
 None
 1.27A 2f7aA-1fioA:
undetectable		 2f7aA-1fioA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 170
LEU A 171
ILE A 177
LEU A  94
ILE A  97
 None
 1.02A 2f7aA-1gsqA:
0.7		 2f7aA-1gsqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU B 330
LEU B 329
ILE B 326
LEU B 406
ILE B 403
 None
 1.03A 2f7aA-1m2vB:
undetectable		 2f7aA-1m2vB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		5 LEU A 169
LEU A 192
ILE A 194
LEU A 218
ILE A 216
 None
 1.21A 2f7aA-1nxzA:
undetectable		 2f7aA-1nxzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2f RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A 139
LEU A 128
ILE A 130
LEU A 146
ILE A 144
 None
 1.24A 2f7aA-1p2fA:
1.5		 2f7aA-1p2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhl PROTEIN (CELL
DIVISION PROTEIN
MUKB)

(Escherichia
coli) 		PF04310
(MukB) 		5 LEU A 188
ILE A 184
PHE A 197
LEU A  51
ILE A  52
 None
 1.27A 2f7aA-1qhlA:
undetectable		 2f7aA-1qhlA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qil TOXIC SHOCK SYNDROME
TOXIN-1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		5 LEU A  10
LEU A   9
ILE A   6
LEU A 143
ARG A 145
 None
 1.23A 2f7aA-1qilA:
undetectable		 2f7aA-1qilA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.10A 2f7aA-1vkoA:
0.6		 2f7aA-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 481
LEU A 483
LEU A 484
LEU A 412
ARG A 411
 None
 1.22A 2f7aA-1xb7A:
undetectable		 2f7aA-1xb7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 LEU A 199
LEU A 187
ILE A 231
LEU A 219
ILE A 258
 None
 1.29A 2f7aA-1zaoA:
undetectable		 2f7aA-1zaoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2o HYPOTHETICAL PROTEIN
BT3146

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A  25
LEU A  28
PHE A 105
LEU A 102
TYR A 209
 None
 1.15A 2f7aA-2a2oA:
undetectable		 2f7aA-2a2oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9i INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-4

(Mus musculus) 		no annotation 5 LEU A  70
LEU A  71
ILE A  11
ARG A  47
ILE A  39
 None
 1.16A 2f7aA-2a9iA:
undetectable		 2f7aA-2a9iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 LEU A 409
LEU A 407
LEU A 406
ILE A 435
LEU A 433
 None
 1.15A 2f7aA-2bmbA:
undetectable		 2f7aA-2bmbA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 645
LEU A 649
ILE A 654
LEU A 673
ILE A 670
 None
 1.13A 2f7aA-2cvtA:
undetectable		 2f7aA-2cvtA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmw SYNAPTOBREVIN-LIKE 1
VARIANT

(Homo sapiens) 		PF13774
(Longin) 		5 LEU A 117
LEU A 121
ILE A  10
LEU A  86
ILE A  89
 None
 1.20A 2f7aA-2dmwA:
undetectable		 2f7aA-2dmwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqx KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07707
(BACK) 		5 LEU A 206
LEU A 207
ILE A 210
PHE A 199
LEU A 164
 None
 1.18A 2f7aA-2eqxA:
undetectable		 2f7aA-2eqxA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 None
 0.18A 2f7aA-2f6gA:
33.6		 2f7aA-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		6 LEU A   3
LEU A  57
ILE A  63
LEU A 101
ARG A 100
ILE A   5
 None
 1.14A 2f7aA-2fe7A:
undetectable		 2f7aA-2fe7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.09A 2f7aA-2fi1A:
undetectable		 2f7aA-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		5 LEU 1 545
LEU 1 598
LEU 1 600
ILE 1 601
ILE 1 514
 None
 1.16A 2f7aA-2fji1:
undetectable		 2f7aA-2fji1:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		5 LEU A 238
LEU A 223
LEU A 218
ARG A 219
ILE A 273
 None
 1.02A 2f7aA-2fq1A:
undetectable		 2f7aA-2fq1A:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		7 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.45A 2f7aA-2h98A:
29.5		 2f7aA-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khe TOXIN-LIKE PROTEIN

(Thermus
thermophilus) 		PF05016
(ParE_toxin) 		6 LEU A  47
LEU A  52
PHE A  55
LEU A  79
ARG A  80
ILE A  66
 None
 1.24A 2f7aA-2kheA:
undetectable		 2f7aA-2kheA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lt3 TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY

(Myxococcus
xanthus) 		no annotation 5 LEU A 106
ILE A 109
LEU A  91
ILE A 102
TYR A  22
 None
 1.27A 2f7aA-2lt3A:
undetectable		 2f7aA-2lt3A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		5 LEU X 244
LEU X 215
PHE X 230
ARG X 225
ILE X 228
 None
 1.08A 2f7aA-2odtX:
undetectable		 2f7aA-2odtX:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0s ABC TRANSPORTER,
PERMEASE PROTEIN,
PUTATIVE

(Porphyromonas
gingivalis) 		no annotation 5 LEU A  64
ILE A 129
PHE A  73
LEU A  97
ILE A  54
 None
 1.30A 2f7aA-2p0sA:
4.2		 2f7aA-2p0sA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 LEU A 262
LEU A 261
ILE A 255
LEU A  28
TYR A 145
 None
 1.24A 2f7aA-2pq6A:
undetectable		 2f7aA-2pq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8q IRON-REGULATED
SURFACE DETERMINANT
E

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 LEU A 227
LEU A 263
PHE A 268
LEU A 191
ILE A 188
 None
 1.25A 2f7aA-2q8qA:
undetectable		 2f7aA-2q8qA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		5 LEU A 418
ILE A 387
PHE A 463
LEU A 464
ILE A 460
 None
 1.29A 2f7aA-2rjqA:
undetectable		 2f7aA-2rjqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 LEU A 185
LEU A 189
ILE A 172
LEU A 159
ILE A 150
 None
 1.28A 2f7aA-2zj8A:
undetectable		 2f7aA-2zj8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.25A 2f7aA-3abbA:
undetectable		 2f7aA-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.09A 2f7aA-3b3jA:
undetectable		 2f7aA-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.82A 2f7aA-3bg0B:
undetectable		 2f7aA-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 289
ILE A 192
LEU A 305
ILE A 303
TYR A 279
 None
 1.19A 2f7aA-3czmA:
undetectable		 2f7aA-3czmA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 248
ILE A 151
LEU A 190
ILE A 136
TYR A 186
 None
 1.28A 2f7aA-3evnA:
1.1		 2f7aA-3evnA:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		7 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 GOL  A   2 (-4.3A)
GOL  A   2 (-3.7A)
None
None
None
None
GOL  A   2 (-4.9A)
 0.29A 2f7aA-3glbA:
29.1		 2f7aA-3glbA:
54.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 LEU A 131
LEU A 117
ILE A 110
LEU A  79
ILE A  95
 None
 1.24A 2f7aA-3h7nA:
undetectable		 2f7aA-3h7nA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.14A 2f7aA-3ho8A:
undetectable		 2f7aA-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU D  29
LEU D  28
ILE D   6
PHE D  33
ILE D  74
 None
 1.16A 2f7aA-3hrdD:
undetectable		 2f7aA-3hrdD:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		5 LEU 4 105
LEU 4 104
ILE 4 357
ILE 4 175
TYR 4  97
 None
 1.29A 2f7aA-3i9v4:
undetectable		 2f7aA-3i9v4:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		5 LEU A 106
LEU A 109
PHE A  81
LEU A  55
ILE A   6
 None
 1.26A 2f7aA-3ib6A:
1.4		 2f7aA-3ib6A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		5 LEU A 109
LEU A 106
PHE A  81
LEU A  55
ILE A   6
 None
 1.29A 2f7aA-3ib6A:
1.4		 2f7aA-3ib6A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 LEU A 112
LEU A 113
ILE A 373
LEU A 133
ILE A 136
 None
 1.15A 2f7aA-3j09A:
undetectable		 2f7aA-3j09A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		5 LEU B 223
LEU B 222
ILE B 216
LEU B 350
ILE B 353
 None
 1.07A 2f7aA-3j9oB:
undetectable		 2f7aA-3j9oB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 LEU D  32
LEU D  34
LEU D  35
PHE D 229
LEU D 189
 None
 1.19A 2f7aA-3jazD:
undetectable		 2f7aA-3jazD:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 IMD  A 313 ( 4.1A)
CL  A 314 ( 4.1A)
IMD  A 313 ( 4.0A)
None
IMD  A 313 ( 4.9A)
None
CL  A 314 (-3.4A)
IMD  A 313 ( 4.1A)
IMD  A 313 (-4.7A)
 0.41A 2f7aA-3k1nA:
31.5		 2f7aA-3k1nA:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 115
LEU A 113
PHE A 206
LEU A 175
ILE A 180
 None
 1.21A 2f7aA-3lijA:
undetectable		 2f7aA-3lijA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.22A 2f7aA-3o75A:
3.2		 2f7aA-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		5 LEU A 153
ILE A  67
PHE A 137
LEU A 110
ILE A 106
 None
 1.28A 2f7aA-3q0xA:
undetectable		 2f7aA-3q0xA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 LEU A  23
ILE A  37
PHE A 172
LEU A 108
ILE A 111
 None
 1.24A 2f7aA-3r75A:
undetectable		 2f7aA-3r75A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 271
LEU A 235
ILE A 238
LEU A 250
ILE A 279
 None
 1.22A 2f7aA-3rg1A:
undetectable		 2f7aA-3rg1A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		5 LEU A 106
LEU A 122
LEU A 121
ILE A 118
ILE A  52
 None
 1.16A 2f7aA-3sy8A:
undetectable		 2f7aA-3sy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 LEU A 178
LEU A 168
LEU A 169
ILE A  93
PHE A 123
 None
 1.29A 2f7aA-3t1iA:
undetectable		 2f7aA-3t1iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 751
ILE A 771
PHE A 703
LEU A 668
ILE A 686
 None
 1.25A 2f7aA-3va6A:
undetectable		 2f7aA-3va6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 LEU A 651
LEU A 653
ILE A 652
PHE A 600
LEU A 536
 None
 1.25A 2f7aA-3vthA:
undetectable		 2f7aA-3vthA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		5 LEU A 286
LEU A 253
LEU A 252
ILE A 254
TYR A 331
 LLP  A 285 ( 4.3A)
None
None
None
None
 1.25A 2f7aA-3w1hA:
undetectable		 2f7aA-3w1hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Escherichia
coli) 		PF04452
(Methyltrans_RNA) 		5 LEU A 169
LEU A 191
ILE A 193
LEU A 217
ILE A 215
 None
 1.21A 2f7aA-4e8bA:
undetectable		 2f7aA-4e8bA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		5 LEU Q 441
LEU Q 511
LEU Q 512
ILE Q 515
ILE Q 445
 None
 1.07A 2f7aA-4h62Q:
undetectable		 2f7aA-4h62Q:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A 171
LEU A 168
ILE A 193
LEU A 209
ILE A 208
 None
 1.25A 2f7aA-4ixuA:
undetectable		 2f7aA-4ixuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 LEU A 347
LEU A 349
LEU A 351
ILE A 325
TYR A 286
 None
 1.04A 2f7aA-4jclA:
undetectable		 2f7aA-4jclA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 LEU B 316
LEU B 336
LEU B 337
ILE B 342
LEU B 320
 None
 1.11A 2f7aA-4kvgB:
undetectable		 2f7aA-4kvgB:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noz ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Burkholderia
cenocepacia) 		PF02566
(OsmC) 		5 LEU A 101
LEU A 138
ILE A 117
PHE A  61
ILE A  82
 None
 1.15A 2f7aA-4nozA:
undetectable		 2f7aA-4nozA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 237
LEU A 238
ILE A 158
PHE A 172
ILE A 200
 HEM  A 501 ( 4.5A)
None
None
None
None
 1.29A 2f7aA-4oqsA:
undetectable		 2f7aA-4oqsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF08759
(GT-D) 		5 LEU A 195
LEU A 143
ILE A 145
LEU A 221
ILE A 219
 None
 1.16A 2f7aA-4phsA:
undetectable		 2f7aA-4phsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		5 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.90A 2f7aA-4q3lA:
undetectable		 2f7aA-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 LEU A 254
LEU A 258
ILE A 261
LEU A 242
ILE A 245
 None
 1.12A 2f7aA-4rbnA:
undetectable		 2f7aA-4rbnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		5 LEU A 267
LEU A 270
LEU A 279
ARG A 278
ILE A 293
 None
 1.16A 2f7aA-4rg8A:
undetectable		 2f7aA-4rg8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 LEU A 376
ILE A 255
PHE A 342
LEU A 344
ILE A 205
 None
 1.13A 2f7aA-4rggA:
undetectable		 2f7aA-4rggA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttw CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		5 LEU A 153
ILE A  67
PHE A 137
LEU A 110
ILE A 106
 None
 1.25A 2f7aA-4ttwA:
undetectable		 2f7aA-4ttwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 LEU A 139
LEU A  52
ILE A 112
LEU A  67
ILE A 283
 None
 1.25A 2f7aA-4w7gA:
undetectable		 2f7aA-4w7gA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 180
LEU B 176
ILE B 173
PHE B  62
LEU B 152
 None
 1.26A 2f7aA-4wj3B:
undetectable		 2f7aA-4wj3B:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 537
ILE B 533
LEU B 519
ARG B 520
ILE B 516
 None
 0.87A 2f7aA-4xmmB:
undetectable		 2f7aA-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xng UNCHARACTERIZED
PROTEIN MG218.1

(Mycoplasma
genitalium) 		no annotation 5 LEU A 138
ILE A 134
LEU A 181
ARG A 182
ILE A 178
 None
 1.10A 2f7aA-4xngA:
undetectable		 2f7aA-4xngA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		5 LEU A 254
LEU A 251
ILE A 293
PHE A 271
ILE A 318
 None
 1.17A 2f7aA-4zmiA:
undetectable		 2f7aA-4zmiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.94A 2f7aA-5b3jA:
undetectable		 2f7aA-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 5 LEU A 434
ILE A 317
PHE A 439
LEU A 461
ILE A 436
 None
 1.17A 2f7aA-5cowA:
undetectable		 2f7aA-5cowA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1i CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Brucella
abortus) 		PF00027
(cNMP_binding) 		5 LEU A  24
LEU A  26
LEU A  27
ILE A 116
PHE A  19
 None
 1.25A 2f7aA-5d1iA:
undetectable		 2f7aA-5d1iA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 LEU B 378
LEU B 375
ILE B 348
PHE B 371
LEU B 328
 None
 1.23A 2f7aA-5dlqB:
undetectable		 2f7aA-5dlqB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 LEU B 101
LEU B 266
ILE B 235
LEU B 114
ILE B 103
 None
 1.24A 2f7aA-5do7B:
undetectable		 2f7aA-5do7B:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.27A 2f7aA-5eioA:
undetectable		 2f7aA-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 LEU A 512
LEU A 478
LEU A 480
LEU A 465
ILE A 486
 None
 1.05A 2f7aA-5gkqA:
undetectable		 2f7aA-5gkqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-FOLD
MODIFIER 1

(Homo sapiens) 		PF03671
(Ufm1) 		5 LEU C  21
LEU C  33
PHE C   6
LEU C  74
ILE C   8
 None
 1.14A 2f7aA-5iaaC:
undetectable		 2f7aA-5iaaC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 LEU A 546
LEU A 486
ARG A 482
ILE A 548
TYR A 656
 None
 1.28A 2f7aA-5idoA:
undetectable		 2f7aA-5idoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 5 LEU B  73
LEU B  37
LEU B  35
ILE B  34
TYR B 146
 None
 1.20A 2f7aA-5l22B:
undetectable		 2f7aA-5l22B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2q SERINE/THREONINE-PRO
TEIN KINASE 40

(Homo sapiens) 		no annotation 5 LEU C  96
LEU C  97
PHE C 217
LEU C 188
ILE C 193
 None
 1.04A 2f7aA-5l2qC:
undetectable		 2f7aA-5l2qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 LEU A 624
LEU A 631
ILE A 634
PHE A 707
LEU A 673
 None
 1.30A 2f7aA-5lmgA:
undetectable		 2f7aA-5lmgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 LEU A 143
LEU A 134
ILE A 154
LEU A 187
ILE A  94
 None
 1.24A 2f7aA-5lq4A:
undetectable		 2f7aA-5lq4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 LEU A   5
ILE A 213
PHE A   9
LEU A  38
ILE A  11
 None
 1.05A 2f7aA-5lsmA:
undetectable		 2f7aA-5lsmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 LEU A 501
LEU A 148
ILE A 502
PHE A 373
LEU A 360
 None
 1.30A 2f7aA-5mz9A:
undetectable		 2f7aA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 21

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF11221
(Med21) 		5 LEU W  80
ILE W  73
LEU U 119
ARG U 120
ILE U 116
 None
 1.03A 2f7aA-5svaW:
undetectable		 2f7aA-5svaW:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		5 LEU A 515
ILE A 507
PHE A 505
ARG A  50
ILE A  48
 None
 1.18A 2f7aA-5u4oA:
2.4		 2f7aA-5u4oA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 5 LEU A 246
LEU A 247
PHE A 231
LEU A  52
ILE A   5
 None
 0.92A 2f7aA-5vaeA:
undetectable		 2f7aA-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 728
PHE A 823
LEU A 794
ILE A 799
TYR A 793
 None
 1.02A 2f7aA-5vilA:
undetectable		 2f7aA-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6h DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		no annotation 5 LEU I 260
LEU I 307
ILE I 303
LEU I 281
ILE I 278
 None
 1.20A 2f7aA-6b6hI:
undetectable		 2f7aA-6b6hI:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 152
LEU A 283
ILE A 343
LEU A 296
ILE A 295
 None
 1.05A 2f7aA-6bacA:
undetectable		 2f7aA-6bacA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 5 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.96A 2f7aA-6d2lA:
undetectable		 2f7aA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU O 540
LEU O 537
ILE O 541
PHE O 566
ILE O 511
 None
 1.30A 2f7aA-6eu2O:
undetectable		 2f7aA-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 ILE D 137
PHE D  95
LEU D  67
ARG D  68
ILE D  64
 None
 1.23A 2f7aA-6f45D:
undetectable		 2f7aA-6f45D:
undetectable