SIMILAR PATTERNS OF AMINO ACIDS FOR 2F78_B_BEZB1004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		4 VAL A 513
SER A 312
ARG A 470
LEU A 469
 None
 0.96A 2f78B-1dcqA:
undetectable		 2f78B-1dcqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhr DIHYDROPTERIDINE
REDUCTASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		4 VAL A 176
LEU A  18
PHE A 203
THR A 199
 None
NAD  A 241 (-4.1A)
None
None
 1.17A 2f78B-1dhrA:
0.3		 2f78B-1dhrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		4 VAL B 115
SER B  90
ARG B 101
THR B 103
 None
 1.04A 2f78B-1i2mB:
undetectable		 2f78B-1i2mB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j89 HIGH AFFINITY
IMMUNOGLOBULIN
EPSILON RECEPTOR
ALPHA-SUBUNIT

(Homo sapiens) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		4 VAL A   7
SER A  76
LEU A  53
PHE A  40
 None
 0.89A 2f78B-1j89A:
undetectable		 2f78B-1j89A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		4 ARG A 534
LEU A 536
PHE A 565
THR A 560
 None
 1.10A 2f78B-1nrfA:
undetectable		 2f78B-1nrfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qup SUPEROXIDE DISMUTASE
1 COPPER CHAPERONE

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu)
PF00403
(HMA) 		4 VAL A  48
SER A  50
LEU A  61
THR A  56
 None
 1.11A 2f78B-1qupA:
undetectable		 2f78B-1qupA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 VAL A  22
SER A  31
HIS A  90
THR A  36
 None
 1.10A 2f78B-1tt4A:
undetectable		 2f78B-1tt4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txc PATHOGENESIS-RELATED
CLASS 10 PROTEIN
SPE-16

(Pachyrhizus
erosus) 		PF00407
(Bet_v_1) 		4 VAL A 131
LEU A  97
PHE A   3
THR A 121
 None
 1.06A 2f78B-1txcA:
0.2		 2f78B-1txcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		4 VAL A 238
LEU A 339
PHE A 324
THR A 342
 None
 1.03A 2f78B-1ue0A:
undetectable		 2f78B-1ue0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 VAL A  68
SER A  65
ARG A 118
THR A 114
 None
 1.09A 2f78B-1uznA:
undetectable		 2f78B-1uznA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		4 VAL A  55
ARG A 376
LEU A  58
HIS A 379
 None
 1.02A 2f78B-1vgqA:
undetectable		 2f78B-1vgqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 VAL A 394
ARG A 398
LEU A 280
THR A 310
 None
 1.11A 2f78B-1w1kA:
undetectable		 2f78B-1w1kA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 VAL A  49
SER A 116
LEU A 126
HIS A  62
 None
None
None
FE  A 401 (-3.6A)
 1.14A 2f78B-1y3tA:
undetectable		 2f78B-1y3tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykg SULFITE REDUCTASE
[NADPH] FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 VAL A 149
SER A 151
LEU A 171
HIS A 131
 None
 1.03A 2f78B-1ykgA:
undetectable		 2f78B-1ykgA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN LIGHT CHAIN
FERRITIN HEAVY CHAIN

(Trichoplusia
ni;
Trichoplusia ni) 		PF00210
(Ferritin)
PF00210
(Ferritin) 		4 VAL M  88
LEU M  79
PHE A  62
THR A  67
 None
 1.08A 2f78B-1z6oM:
undetectable		 2f78B-1z6oM:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		4 VAL A 188
SER A 190
LEU A 320
THR A 130
 None
 1.14A 2f78B-1zapA:
undetectable		 2f78B-1zapA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auj DNA-DIRECTED RNA
POLYMERASE BETA'
CHAIN

(Thermus
aquaticus) 		no annotation 4 VAL D 347
ARG D 209
LEU D 387
PHE D 207
 None
 1.15A 2f78B-2aujD:
undetectable		 2f78B-2aujD:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 VAL A  93
SER A  97
ARG A 158
LEU A 169
 None
 1.12A 2f78B-2dg8A:
undetectable		 2f78B-2dg8A:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		4 VAL A 143
SER A 150
PHE A 154
THR A 138
 None
 0.97A 2f78B-2dupA:
undetectable		 2f78B-2dupA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		7 VAL A  97
SER A  99
ARG A 146
LEU A 147
PHE A 203
HIS A 206
THR A 267
 None
 0.55A 2f78B-2f6gA:
33.5		 2f78B-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 VAL A 307
LEU A 178
PHE A 323
THR A 173
 None
 1.13A 2f78B-2g0tA:
undetectable		 2f78B-2g0tA:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 VAL A  97
SER A  99
ARG A 146
LEU A 147
 CL  A 315 ( 4.6A)
CL  A 314 (-2.9A)
None
None
 1.10A 2f78B-2h98A:
29.8		 2f78B-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5p LIPOCALIN 12

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 VAL A 143
SER A 158
LEU A 105
THR A  76
 None
 1.11A 2f78B-2l5pA:
undetectable		 2f78B-2l5pA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7u METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		4 VAL A 460
SER A 477
ARG A 452
LEU A 455
 None
 1.00A 2f78B-2m7uA:
undetectable		 2f78B-2m7uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbv UBIQUILIN-2

(Homo sapiens) 		PF00240
(ubiquitin) 		4 SER B  67
LEU B  74
PHE B  65
THR B  39
 None
 1.15A 2f78B-2nbvB:
undetectable		 2f78B-2nbvB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		4 VAL A1165
SER A1186
LEU A1170
THR A1152
 None
 1.03A 2f78B-2nxgA:
undetectable		 2f78B-2nxgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X 294
SER X 292
LEU X 336
HIS X 337
 None
 1.12A 2f78B-2p3gX:
undetectable		 2f78B-2p3gX:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 VAL A 234
SER A 230
LEU A 204
THR A 245
 None
 0.99A 2f78B-2ptsA:
undetectable		 2f78B-2ptsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		4 SER A  77
ARG A 191
LEU A 192
THR A 117
 None
 1.17A 2f78B-2q0xA:
undetectable		 2f78B-2q0xA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A  82
LEU A 299
HIS A 228
THR A 221
 None
 1.07A 2f78B-2zauA:
undetectable		 2f78B-2zauA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 SER A  70
ARG A  79
LEU A  82
THR A  75
 EDO  A 401 (-3.6A)
None
None
None
 1.15A 2f78B-3bjdA:
undetectable		 2f78B-3bjdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 VAL A  66
SER A  70
ARG A  79
THR A  75
 EDO  A 401 ( 4.3A)
EDO  A 401 (-3.6A)
None
None
 1.08A 2f78B-3bjdA:
undetectable		 2f78B-3bjdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		4 VAL A 247
PHE A 223
HIS A 222
THR A 213
 None
 1.15A 2f78B-3bkhA:
undetectable		 2f78B-3bkhA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 VAL A 266
SER A 268
ARG A 279
THR A 195
 None
 1.09A 2f78B-3by9A:
undetectable		 2f78B-3by9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 140
PHE A 103
HIS A  99
THR A 123
 None
 1.16A 2f78B-3d46A:
undetectable		 2f78B-3d46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 258
SER A 260
PHE A 172
HIS A 209
 None
 1.11A 2f78B-3dtyA:
undetectable		 2f78B-3dtyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 130
PHE A  94
HIS A  90
THR A 114
 None
 1.17A 2f78B-3ekgA:
undetectable		 2f78B-3ekgA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		4 VAL A 359
SER A 128
LEU A 346
PHE A 384
 None
 0.90A 2f78B-3ez6A:
undetectable		 2f78B-3ez6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A 109
LEU A 325
HIS A 274
THR A 267
 None
None
AP2  A 393 ( 4.3A)
PO4  A 394 ( 3.3A)
 1.13A 2f78B-3fd5A:
undetectable		 2f78B-3fd5A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf8 PUTATIVE
POLYSACCHARIDE
BINDING PROTEINS
(DUF1812)

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		4 SER A 286
ARG A 168
LEU A 166
THR A 143
 None
 1.17A 2f78B-3gf8A:
undetectable		 2f78B-3gf8A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 VAL A  97
SER A  99
ARG A 146
LEU A 147
 CCU  A   3 (-4.2A)
CCU  A   3 (-2.9A)
None
CCU  A   3 (-4.4A)
 0.56A 2f78B-3glbA:
29.8		 2f78B-3glbA:
54.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		4 VAL A  97
SER A  99
ARG A 146
PHE A 203
 CCU  A   3 (-4.2A)
CCU  A   3 (-2.9A)
None
None
 0.91A 2f78B-3glbA:
29.8		 2f78B-3glbA:
54.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		4 VAL A 106
SER A 105
LEU A 258
HIS A  38
 None
 1.12A 2f78B-3gzjA:
1.0		 2f78B-3gzjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ha2 NADPH-QUINONE
REDUCTASE

(Pediococcus
pentosaceus) 		PF02525
(Flavodoxin_2) 		4 SER A 100
LEU A  12
PHE A  21
THR A  17
 None
None
None
SO4  A 178 (-2.9A)
 1.02A 2f78B-3ha2A:
undetectable		 2f78B-3ha2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		4 VAL A 190
PHE A 150
HIS A  99
THR A 133
 None
 1.17A 2f78B-3i1jA:
undetectable		 2f78B-3i1jA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533

(Methanocaldococcus
jannaschii) 		PF01850
(PIN) 		4 VAL A  35
SER A 135
ARG A  40
LEU A  44
 None
None
ACT  A 168 ( 4.1A)
None
 1.18A 2f78B-3i8oA:
undetectable		 2f78B-3i8oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 VAL A 270
LEU A 265
PHE A 227
THR A 432
 None
 1.16A 2f78B-3jbhA:
undetectable		 2f78B-3jbhA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 280
SER A 306
ARG A 157
LEU A 155
 None
 0.62A 2f78B-3jtmA:
undetectable		 2f78B-3jtmA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		7 VAL A  97
SER A  99
ARG A 146
LEU A 147
PHE A 203
HIS A 206
THR A 267
 None
 0.75A 2f78B-3k1nA:
32.8		 2f78B-3k1nA:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3las PUTATIVE CARBONIC
ANHYDRASE

(Streptococcus
mutans) 		PF00484
(Pro_CA) 		4 VAL A 131
SER A 130
LEU A  89
HIS A  91
 None
None
None
ZN  A 167 (-3.2A)
 0.89A 2f78B-3lasA:
undetectable		 2f78B-3lasA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		4 VAL A 134
SER A 132
LEU A 245
THR A 241
 None
 1.15A 2f78B-3m1aA:
undetectable		 2f78B-3m1aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1

(Bos taurus) 		PF00481
(PP2C) 		4 SER A  36
LEU A  69
HIS A 122
THR A  60
 None
 1.15A 2f78B-3mq3A:
undetectable		 2f78B-3mq3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 VAL A  13
LEU A  24
PHE A  89
THR A  31
 None
 1.10A 2f78B-3mwsA:
undetectable		 2f78B-3mwsA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pin PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Saccharomyces
cerevisiae) 		PF01625
(PMSR) 		4 VAL B  80
LEU B  37
PHE B  96
THR B  29
 None
 1.10A 2f78B-3pinB:
undetectable		 2f78B-3pinB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOA

(Methylocystis
sp. M) 		no annotation 4 VAL J  57
SER J 122
PHE J 193
HIS J 192
 None
 1.04A 2f78B-3rfrJ:
undetectable		 2f78B-3rfrJ:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN

(Mus musculus) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 VAL A 464
ARG A 462
LEU A 615
PHE A 740
 None
 1.14A 2f78B-3tbkA:
undetectable		 2f78B-3tbkA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A 196
SER A 202
PHE A 188
HIS A 189
 None
 1.12A 2f78B-3tqpA:
undetectable		 2f78B-3tqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A  90
LEU A 306
HIS A 236
THR A 229
 None
None
None
MG  A 401 ( 4.1A)
 1.03A 2f78B-3u0oA:
undetectable		 2f78B-3u0oA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3g RIBONUCLEASE H

(uncultured
organism) 		no annotation 4 VAL D  23
SER D  36
ARG D  55
LEU D  57
 None
 1.16A 2f78B-3u3gD:
undetectable		 2f78B-3u3gD:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		4 VAL A 209
SER A 202
LEU A 250
THR A 243
 None
 1.17A 2f78B-3vasA:
undetectable		 2f78B-3vasA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Nostoc sp. PCC
7120) 		PF01590
(GAF) 		4 VAL A  56
SER A  73
ARG A  48
LEU A  51
 None
 1.13A 2f78B-3w2zA:
undetectable		 2f78B-3w2zA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A  92
LEU A 118
PHE A  99
THR A  96
 None
 1.09A 2f78B-4dibA:
undetectable		 2f78B-4dibA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dth VGRG PROTEIN

(Vibrio cholerae) 		PF16671
(ACD) 		4 VAL A 165
SER A  11
LEU A 182
THR A 177
 None
 1.08A 2f78B-4dthA:
undetectable		 2f78B-4dthA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 VAL A 875
SER A 874
LEU A 860
THR A 831
 None
 1.07A 2f78B-4ecnA:
undetectable		 2f78B-4ecnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago
maydis;
Ustilago maydis) 		PF08661
(Rep_fac-A_3)
PF01336
(tRNA_anti-codon) 		4 VAL A  99
SER A 103
ARG B 163
HIS B 162
 None
 1.02A 2f78B-4gnxA:
undetectable		 2f78B-4gnxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im8 ADVANCED GLYCATION
END-PRODUCTS
RECEPTOR

(Mus musculus) 		PF00047
(ig)
PF08205
(C2-set_2) 		4 VAL A 172
SER A 189
LEU A 163
HIS A 157
 None
 1.06A 2f78B-4im8A:
undetectable		 2f78B-4im8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzk L-ARABINOSE ABC
TRANSPORTER,
PERIPLASMIC
L-ARABINOSE-BINDING
PROTEIN

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 VAL A 199
ARG A 169
LEU A 189
THR A 182
 None
 1.17A 2f78B-4kzkA:
2.0		 2f78B-4kzkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A 170
PHE A 125
HIS A  83
THR A 108
 IOD  A 406 ( 4.9A)
None
None
None
 1.12A 2f78B-4lisA:
undetectable		 2f78B-4lisA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp4 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF08205
(C2-set_2) 		4 VAL A 173
SER A 190
LEU A 164
HIS A 158
 None
 1.15A 2f78B-4lp4A:
undetectable		 2f78B-4lp4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		4 VAL A 101
LEU A  63
PHE A 182
THR A  66
 None
 1.04A 2f78B-4m5pA:
undetectable		 2f78B-4m5pA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		4 VAL A 214
SER A 211
ARG A 181
THR A 187
 None
None
PO4  A 401 (-2.8A)
PO4  A 401 (-3.5A)
 1.18A 2f78B-4ombA:
13.7		 2f78B-4ombA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		4 VAL A  95
SER A 118
LEU A  60
THR A 266
 None
 1.05A 2f78B-4p98A:
undetectable		 2f78B-4p98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 VAL A 294
LEU A  98
PHE A 233
THR A 225
 None
 0.91A 2f78B-4pprA:
undetectable		 2f78B-4pprA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		4 VAL A 214
SER A 211
ARG A 181
THR A 187
 None
None
PO4  A 401 (-2.7A)
PO4  A 401 (-3.5A)
 1.14A 2f78B-4pqjA:
14.3		 2f78B-4pqjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		4 VAL A 261
LEU A 273
PHE A 294
THR A 342
 None
 1.09A 2f78B-4txkA:
undetectable		 2f78B-4txkA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 VAL A 226
SER A 241
LEU A 171
THR A 210
 None
 1.07A 2f78B-4um8A:
undetectable		 2f78B-4um8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4web HEPATITIS C VIRUS
ENVELOPE
GLYCOPROTEIN 2
MOUSE FAB HEAVY
CHAIN

(Hepacivirus C;
Mus musculus) 		PF01560
(HCV_NS1)
PF07654
(C1-set)
PF07686
(V-set) 		4 ARG E 643
LEU E 644
PHE H  27
THR H  32
 None
 1.08A 2f78B-4webE:
undetectable		 2f78B-4webE:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybr NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01467
(CTP_transf_like) 		4 VAL A  37
SER A  74
LEU A 102
THR A  89
 None
 1.18A 2f78B-4ybrA:
undetectable		 2f78B-4ybrA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyc PUTATIVE
TRIMETHYLAMINE
METHYLTRANSFERASE

(Sinorhizobium
meliloti) 		PF06253
(MTTB) 		4 VAL A 270
SER A 272
ARG A 354
PHE A 353
 None
UNL  A 601 ( 4.7A)
UNL  A 601 ( 3.0A)
None
 1.13A 2f78B-4yycA:
undetectable		 2f78B-4yycA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhb ANKYRIN
REPEAT-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF12796
(Ank_2) 		4 VAL A  23
SER A  24
ARG A  56
LEU A  54
 None
 1.12A 2f78B-4zhbA:
undetectable		 2f78B-4zhbA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 VAL A 171
SER A 137
LEU A  46
PHE A 159
 None
 1.16A 2f78B-4zxlA:
undetectable		 2f78B-4zxlA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 282
LEU A 335
PHE A 318
THR A 328
 None
 1.08A 2f78B-5b37A:
undetectable		 2f78B-5b37A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9l PLL LECTIN

(Photorhabdus
luminescens) 		PF03984
(DUF346) 		4 SER A 215
ARG A 243
LEU A 242
HIS A 244
 None
 1.07A 2f78B-5c9lA:
undetectable		 2f78B-5c9lA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 VAL A 162
LEU A 120
HIS A 103
THR A 109
 None
 0.92A 2f78B-5cm9A:
undetectable		 2f78B-5cm9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 SER A 305
LEU A 287
PHE A 296
THR A 291
 None
 1.04A 2f78B-5dl6A:
undetectable		 2f78B-5dl6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f17 NON-STRUCTURAL
PROTEIN 11

(Equine
arteritis virus) 		no annotation 4 VAL A  74
SER A 102
ARG A 104
PHE A 105
 None
 0.72A 2f78B-5f17A:
undetectable		 2f78B-5f17A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9q MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN YKNZ

(Bacillus
amyloliquefaciens) 		PF12704
(MacB_PCD) 		4 SER A 177
LEU A  79
PHE A 164
THR A 173
 None
 1.12A 2f78B-5f9qA:
undetectable		 2f78B-5f9qA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gha SULFUR TRANSFERASE
TTUA

(Thermus
thermophilus) 		PF01171
(ATP_bind_3) 		4 VAL A  12
SER A 208
LEU A  19
PHE A  30
 None
 1.00A 2f78B-5ghaA:
undetectable		 2f78B-5ghaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 VAL A 122
LEU A  73
PHE A 230
THR A  82
 None
 1.12A 2f78B-5jxkA:
undetectable		 2f78B-5jxkA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k82 APOLIPOPROTEIN B
MRNA EDITING ENZYME,
CATALYTIC
PEPTIDE-LIKE
3G,APOLIPOPROTEIN B
MRNA EDITING ENZYME,
CATALYTIC
PEPTIDE-LIKE 3G

(Macaca mulatta) 		PF08210
(APOBEC_N) 		4 VAL A 120
LEU A 135
PHE A 126
THR A 188
 None
 1.12A 2f78B-5k82A:
undetectable		 2f78B-5k82A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 VAL A 461
SER A 478
ARG A 453
LEU A 456
 None
 1.02A 2f78B-5m85A:
undetectable		 2f78B-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 VAL A 740
LEU A 745
PHE A 767
THR A 753
 EDO  A1023 (-3.6A)
None
None
None
 1.12A 2f78B-5nn8A:
undetectable		 2f78B-5nn8A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 4 VAL A  76
SER A  73
ARG A 126
THR A 122
 None
 1.11A 2f78B-5ovkA:
undetectable		 2f78B-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovl 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Mycolicibacterium
smegmatis) 		no annotation 4 VAL A  76
SER A  73
ARG A 126
THR A 122
 None
 1.09A 2f78B-5ovlA:
undetectable		 2f78B-5ovlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 PRE-MRNA-PROCESSING
FACTOR 39
PROTEIN NAM8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 VAL E 435
SER E 431
LEU E 472
PHE F 522
 None
 1.12A 2f78B-5uz5E:
undetectable		 2f78B-5uz5E:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrv PROTEIN REGULATED BY
ACID PH

(Agrobacterium
fabrum) 		PF09924
(DUF2156) 		4 SER A 720
ARG A 561
LEU A 559
THR A 546
 None
 1.08A 2f78B-5vrvA:
undetectable		 2f78B-5vrvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		4 VAL A3267
SER A3149
LEU A3135
PHE A3151
 None
 0.93A 2f78B-5xauA:
undetectable		 2f78B-5xauA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp U4 LIGHT CHAIN

(Mus musculus) 		no annotation 4 VAL B  58
ARG B  54
LEU B  47
THR B  63
 None
 1.07A 2f78B-6bspB:
undetectable		 2f78B-6bspB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL
ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation 		4 SER D 274
ARG D 279
LEU A 296
THR D 289
 None
 1.16A 2f78B-6f5dD:
undetectable		 2f78B-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 VAL A 344
SER A 348
ARG A 317
LEU A 316
 None
 1.10A 2f78B-6f5oA:
undetectable		 2f78B-6f5oA:
undetectable