SIMILAR PATTERNS OF AMINO ACIDS FOR 2F78_A_BEZA1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 5 LEU A 137
LEU A 138
ILE A 117
LEU A 335
ILE A  17
 None
 1.17A 2f78A-1bwdA:
undetectable		 2f78A-1bwdA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE
MYELOPEROXIDASE

(Homo sapiens;
Homo sapiens) 		PF03098
(An_peroxidase)
PF03098
(An_peroxidase) 		5 LEU C 415
LEU C 406
LEU C 128
ARG A  62
ILE C 144
 None
 1.27A 2f78A-1d7wC:
undetectable		 2f78A-1d7wC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		5 LEU A 281
ILE A 279
PHE A 347
LEU A 119
ILE A 116
 None
 1.19A 2f78A-1dhsA:
0.0		 2f78A-1dhsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 LEU C 184
LEU C 181
ILE C 233
ARG C 492
ILE C 491
 None
 1.27A 2f78A-1ea9C:
undetectable		 2f78A-1ea9C:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF01180
(DHO_dh) 		5 LEU A 190
LEU A 194
ILE A 197
ILE A 173
TYR A 155
 None
 1.19A 2f78A-1f76A:
undetectable		 2f78A-1f76A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 170
LEU A 171
ILE A 177
LEU A  94
ILE A  97
 None
 1.06A 2f78A-1gsqA:
undetectable		 2f78A-1gsqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU B 330
LEU B 329
ILE B 326
LEU B 406
ILE B 403
 None
 1.02A 2f78A-1m2vB:
undetectable		 2f78A-1m2vB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT

(Klebsiella
pneumoniae) 		PF03830
(PTSIIB_sorb) 		5 LEU A 103
LEU A 143
LEU A 141
ILE A 154
ILE A   9
 None
 1.13A 2f78A-1nrzA:
undetectable		 2f78A-1nrzA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		5 LEU A 131
LEU A 134
ILE A   5
LEU A  11
ILE A  15
 None
 1.26A 2f78A-1o6dA:
3.1		 2f78A-1o6dA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
DELTA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02932
(Neur_chan_memb)
PF02932
(Neur_chan_memb) 		5 LEU B 241
LEU B 234
LEU B 237
ILE B 233
LEU C 264
 None
 1.13A 2f78A-1oedB:
undetectable		 2f78A-1oedB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2f RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A 157
LEU A 155
LEU A 154
ILE A 130
PHE A 215
 None
 1.25A 2f78A-1p2fA:
undetectable		 2f78A-1p2fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 LEU A 212
LEU A 215
ILE A 221
PHE A 155
TYR A 185
 None
 1.16A 2f78A-1vh1A:
undetectable		 2f78A-1vh1A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		5 LEU A  69
LEU A 234
ILE A 232
LEU A 142
ILE A 144
 None
 1.06A 2f78A-1vkoA:
undetectable		 2f78A-1vkoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		5 LEU A  66
ILE A  89
LEU A 152
ILE A 104
TYR A 171
 None
 1.25A 2f78A-1xfuA:
undetectable		 2f78A-1xfuA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9i INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-4

(Mus musculus) 		no annotation 5 LEU A  70
LEU A  71
ILE A  11
ARG A  47
ILE A  39
 None
 1.18A 2f78A-2a9iA:
undetectable		 2f78A-2a9iA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 645
LEU A 649
ILE A 654
LEU A 673
ILE A 670
 None
 1.24A 2f78A-2cvtA:
undetectable		 2f78A-2cvtA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmw SYNAPTOBREVIN-LIKE 1
VARIANT

(Homo sapiens) 		PF13774
(Longin) 		5 LEU A 117
LEU A 121
ILE A  10
LEU A  86
ILE A  89
 None
 1.18A 2f78A-2dmwA:
undetectable		 2f78A-2dmwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqx KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07707
(BACK) 		5 LEU A 206
LEU A 207
ILE A 210
PHE A 199
LEU A 164
 None
 1.26A 2f78A-2eqxA:
undetectable		 2f78A-2eqxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 LEU A 375
LEU A 368
ILE A 352
LEU A 320
ILE A 317
 None
 1.16A 2f78A-2f5uA:
undetectable		 2f78A-2f5uA:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 None
 0.37A 2f78A-2f6gA:
34.4		 2f78A-2f6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe7 PROBABLE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		6 LEU A   3
LEU A  57
ILE A  63
LEU A 101
ARG A 100
ILE A   5
 None
 1.07A 2f78A-2fe7A:
undetectable		 2f78A-2fe7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A  91
ILE A  94
LEU A 184
ARG A 185
ILE A 181
 None
 1.01A 2f78A-2fi1A:
undetectable		 2f78A-2fi1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		5 LEU 1 545
LEU 1 598
LEU 1 600
ILE 1 601
ILE 1 514
 None
 1.16A 2f78A-2fji1:
undetectable		 2f78A-2fji1:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		7 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 None
 0.66A 2f78A-2h98A:
29.8		 2f78A-2h98A:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khe TOXIN-LIKE PROTEIN

(Thermus
thermophilus) 		PF05016
(ParE_toxin) 		6 LEU A  47
LEU A  52
PHE A  55
LEU A  79
ARG A  80
ILE A  66
 None
 1.27A 2f78A-2kheA:
undetectable		 2f78A-2kheA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		5 LEU A 110
LEU A 111
LEU A 124
LEU A  80
ILE A  82
 None
 1.23A 2f78A-2knqA:
undetectable		 2f78A-2knqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0s ABC TRANSPORTER,
PERMEASE PROTEIN,
PUTATIVE

(Porphyromonas
gingivalis) 		no annotation 5 LEU A  64
ILE A 129
PHE A  73
LEU A  97
ILE A  54
 None
 1.24A 2f78A-2p0sA:
4.5		 2f78A-2p0sA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 202
ILE A  99
PHE A 203
LEU A 235
ILE A 200
 None
 1.23A 2f78A-2pjrA:
undetectable		 2f78A-2pjrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 LEU A  35
LEU A  40
PHE A 106
LEU A  59
ILE A  30
 None
 1.26A 2f78A-2r98A:
undetectable		 2f78A-2r98A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  68
PHE A 162
LEU A 130
ILE A 135
TYR A 129
 None
 1.15A 2f78A-2w4kA:
undetectable		 2f78A-2w4kA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 238
LEU A 240
LEU A 241
ILE A 158
LEU A 215
 None
HEM  A1430 (-4.6A)
None
None
None
 1.23A 2f78A-3abbA:
undetectable		 2f78A-3abbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.08A 2f78A-3b3jA:
undetectable		 2f78A-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.73A 2f78A-3bg0B:
undetectable		 2f78A-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A 776
LEU A 772
ILE A 769
PHE A 720
LEU A 703
 None
 1.26A 2f78A-3eh1A:
1.7		 2f78A-3eh1A:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		7 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ILE A 269
 GOL  A   2 (-4.3A)
GOL  A   2 (-3.7A)
None
None
None
None
GOL  A   2 (-4.9A)
 0.52A 2f78A-3glbA:
29.7		 2f78A-3glbA:
54.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv5 DNA POLYMERASE IOTA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 LEU B 344
LEU B 390
ILE B 386
LEU B 325
ILE B 321
 None
 1.23A 2f78A-3gv5B:
undetectable		 2f78A-3gv5B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 LEU A 131
LEU A 117
ILE A 110
LEU A  79
ILE A  95
 None
 1.22A 2f78A-3h7nA:
undetectable		 2f78A-3h7nA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A1030
LEU A1032
LEU A1033
ILE A1050
ARG A 496
 None
 1.24A 2f78A-3ho8A:
undetectable		 2f78A-3ho8A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 LEU D  32
LEU D  34
LEU D  35
PHE D 229
LEU D 189
 None
 1.24A 2f78A-3jazD:
undetectable		 2f78A-3jazD:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		9 LEU A 100
LEU A 104
LEU A 105
ILE A 108
PHE A 144
LEU A 159
ARG A 160
ILE A 269
TYR A 293
 IMD  A 313 ( 4.1A)
CL  A 314 ( 4.1A)
IMD  A 313 ( 4.0A)
None
IMD  A 313 ( 4.9A)
None
CL  A 314 (-3.4A)
IMD  A 313 ( 4.1A)
IMD  A 313 (-4.7A)
 0.53A 2f78A-3k1nA:
32.3		 2f78A-3k1nA:
74.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		5 LEU A 366
LEU A 287
ILE A 367
PHE A 314
LEU A 320
 None
 1.27A 2f78A-3kq5A:
undetectable		 2f78A-3kq5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 790
ILE A 758
PHE A1162
LEU A 822
ILE A 821
 None
 1.26A 2f78A-3l4kA:
undetectable		 2f78A-3l4kA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 115
LEU A 113
PHE A 206
LEU A 175
ILE A 180
 None
 1.17A 2f78A-3lijA:
undetectable		 2f78A-3lijA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 LEU A  94
LEU A  83
ILE A  79
PHE A  66
ILE A  96
 None
 1.18A 2f78A-3o75A:
3.1		 2f78A-3o75A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 LEU A  53
LEU A  50
LEU A 345
ARG A 343
ILE A 335
 None
 1.23A 2f78A-3r75A:
undetectable		 2f78A-3r75A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		5 LEU A 151
ILE A 145
LEU A  26
ARG A  29
ILE A  31
 None
 1.18A 2f78A-3rofA:
undetectable		 2f78A-3rofA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 LEU A 794
LEU A 755
ILE A 731
PHE A 781
LEU A 802
 None
IOD  A 956 ( 4.2A)
None
None
None
 1.23A 2f78A-3s1sA:
undetectable		 2f78A-3s1sA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		5 LEU A 106
LEU A 122
LEU A 121
ILE A 118
ILE A  52
 None
 1.19A 2f78A-3sy8A:
undetectable		 2f78A-3sy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 LEU A   4
LEU A  37
ILE A  39
LEU A 178
ILE A 176
 None
 1.21A 2f78A-3t7bA:
undetectable		 2f78A-3t7bA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		5 LEU A 584
LEU A 586
LEU A 587
ILE A 457
PHE A 549
 None
 1.19A 2f78A-3tbfA:
0.8		 2f78A-3tbfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ups IOJAP-LIKE PROTEIN

(Zymomonas
mobilis) 		PF02410
(RsfS) 		5 LEU A  22
LEU A  20
LEU A  19
ILE A  98
LEU A  27
 None
 1.16A 2f78A-3upsA:
undetectable		 2f78A-3upsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 751
ILE A 771
PHE A 703
LEU A 668
ILE A 686
 None
 1.20A 2f78A-3va6A:
undetectable		 2f78A-3va6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 LEU A 651
LEU A 653
ILE A 652
PHE A 600
LEU A 536
 None
 1.17A 2f78A-3vthA:
undetectable		 2f78A-3vthA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 607
LEU A 608
PHE A 711
LEU A 683
TYR A 682
 None
 1.13A 2f78A-4at3A:
undetectable		 2f78A-4at3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		5 LEU A 284
ILE A 269
PHE A 202
LEU A 210
ILE A 260
 None
 1.26A 2f78A-4cmfA:
undetectable		 2f78A-4cmfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcu 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF02348
(CTP_transf_3) 		5 LEU A 213
LEU A 216
ILE A 222
PHE A 156
TYR A 186
 None
 1.15A 2f78A-4fcuA:
undetectable		 2f78A-4fcuA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		5 LEU A 177
LEU A  92
PHE A 193
LEU A 161
ILE A 157
 None
 1.23A 2f78A-4fe2A:
undetectable		 2f78A-4fe2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 LEU A 152
LEU A 149
ILE A 249
LEU A 302
ILE A 310
 None
 1.19A 2f78A-4fl0A:
undetectable		 2f78A-4fl0A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		5 LEU Q 441
LEU Q 511
LEU Q 512
ILE Q 515
ILE Q 445
 None
 1.19A 2f78A-4h62Q:
undetectable		 2f78A-4h62Q:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 LEU A 347
LEU A 349
LEU A 351
ILE A 325
TYR A 286
 None
 1.11A 2f78A-4jclA:
undetectable		 2f78A-4jclA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnq THIOREDOXIN
REDUCTASE

(Brucella
melitensis) 		PF07992
(Pyr_redox_2) 		5 LEU A 259
LEU A 267
PHE A 255
LEU A 109
ILE A 281
 None
 1.11A 2f78A-4jnqA:
undetectable		 2f78A-4jnqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noz ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Burkholderia
cenocepacia) 		PF02566
(OsmC) 		5 LEU A 101
LEU A 138
ILE A 117
PHE A  61
ILE A  82
 None
 1.07A 2f78A-4nozA:
undetectable		 2f78A-4nozA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		5 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.85A 2f78A-4q3lA:
undetectable		 2f78A-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 LEU A 254
LEU A 258
ILE A 261
LEU A 242
ILE A 245
 None
 1.12A 2f78A-4rbnA:
undetectable		 2f78A-4rbnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		5 LEU A 139
LEU A  52
ILE A 112
LEU A  67
ILE A 283
 None
 1.25A 2f78A-4w7gA:
undetectable		 2f78A-4w7gA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Pseudomonas
aeruginosa) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU B 180
LEU B 176
ILE B 173
PHE B  62
LEU B 152
 None
 1.14A 2f78A-4wj3B:
undetectable		 2f78A-4wj3B:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 LEU A 550
LEU A 547
ILE A 261
LEU A 243
ILE A 553
 None
 1.05A 2f78A-4x1zA:
undetectable		 2f78A-4x1zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 LEU B 537
ILE B 533
LEU B 519
ARG B 520
ILE B 516
 None
 0.85A 2f78A-4xmmB:
undetectable		 2f78A-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xng UNCHARACTERIZED
PROTEIN MG218.1

(Mycoplasma
genitalium) 		no annotation 5 LEU A 138
ILE A 134
LEU A 181
ARG A 182
ILE A 178
 None
 1.02A 2f78A-4xngA:
undetectable		 2f78A-4xngA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 149
LEU A 146
ILE A 144
PHE A 152
ILE A 174
 None
None
NAG  A 702 (-4.8A)
None
None
 1.23A 2f78A-4z64A:
undetectable		 2f78A-4z64A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 620
LEU A 680
ILE A 700
LEU A 599
ILE A 602
 None
 1.15A 2f78A-5a0zA:
undetectable		 2f78A-5a0zA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 LEU A 228
LEU A 225
PHE A 218
LEU A 242
ILE A 166
 None
 0.99A 2f78A-5b3jA:
undetectable		 2f78A-5b3jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cow PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
remanei) 		no annotation 5 LEU A 434
ILE A 317
PHE A 439
LEU A 461
ILE A 436
 None
 1.13A 2f78A-5cowA:
undetectable		 2f78A-5cowA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1i CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Brucella
abortus) 		PF00027
(cNMP_binding) 		5 LEU A  24
LEU A  26
LEU A  27
ILE A 116
PHE A  19
 None
 1.10A 2f78A-5d1iA:
undetectable		 2f78A-5d1iA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 LEU B 378
LEU B 375
ILE B 348
PHE B 371
LEU B 328
 None
 1.20A 2f78A-5dlqB:
undetectable		 2f78A-5dlqB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  73
LEU A  97
ILE A  95
PHE A  19
ILE A   8
 None
NAP  A 401 (-4.9A)
None
None
None
 1.20A 2f78A-5eioA:
undetectable		 2f78A-5eioA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esp I-PANMI

(Podospora
anserina) 		PF00961
(LAGLIDADG_1) 		5 LEU A 126
LEU A 127
ILE A 151
LEU A 144
ILE A  27
 None
 1.20A 2f78A-5espA:
undetectable		 2f78A-5espA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 LEU A 512
LEU A 478
LEU A 480
LEU A 465
ILE A 486
 None
 1.14A 2f78A-5gkqA:
undetectable		 2f78A-5gkqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 ILE C 762
PHE C 682
LEU C 852
ARG C 757
ILE C 683
 None
 1.24A 2f78A-5hr4C:
1.4		 2f78A-5hr4C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 LEU A 196
LEU A 227
LEU A 193
PHE A 155
LEU A 208
 None
 1.24A 2f78A-5it1A:
undetectable		 2f78A-5it1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 440
PHE A 534
LEU A 502
ILE A 507
TYR A 501
 None
 1.21A 2f78A-5jznA:
undetectable		 2f78A-5jznA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l22 ABC TRANSPORTER
(HLYB SUBFAMILY)

(Aquifex
aeolicus) 		no annotation 5 LEU B  73
LEU B  37
LEU B  35
ILE B  34
TYR B 146
 None
 1.20A 2f78A-5l22B:
undetectable		 2f78A-5l22B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2q SERINE/THREONINE-PRO
TEIN KINASE 40

(Homo sapiens) 		no annotation 5 LEU C  96
LEU C  97
PHE C 217
LEU C 188
ILE C 193
 None
 0.95A 2f78A-5l2qC:
undetectable		 2f78A-5l2qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 LEU B 168
LEU B  94
LEU B 138
ILE B 134
ILE B 176
 None
 1.22A 2f78A-5l9wB:
undetectable		 2f78A-5l9wB:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldk RNA 2',3'-CYCLIC
PHOSPHODIESTERASE

(Escherichia
coli) 		PF02834
(LigT_PEase) 		5 LEU A  46
LEU A 106
ILE A  67
PHE A 152
LEU A 174
 None
 1.19A 2f78A-5ldkA:
undetectable		 2f78A-5ldkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 LEU A 143
LEU A 134
ILE A 154
LEU A 187
ILE A  94
 None
 1.21A 2f78A-5lq4A:
undetectable		 2f78A-5lq4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		5 LEU D 603
LEU D   2
PHE D 475
ILE D 478
TYR D  10
 None
 1.19A 2f78A-5mg3D:
undetectable		 2f78A-5mg3D:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 LEU A 501
LEU A 148
ILE A 502
PHE A 373
LEU A 360
 None
 1.26A 2f78A-5mz9A:
undetectable		 2f78A-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 LEU A 132
LEU A 157
LEU A 158
LEU A  35
ILE A  39
 None
 1.19A 2f78A-5oc9A:
undetectable		 2f78A-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 21

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF11221
(Med21) 		5 LEU W  80
ILE W  73
LEU U 119
ARG U 120
ILE U 116
 None
 1.09A 2f78A-5svaW:
undetectable		 2f78A-5svaW:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 5 LEU A 246
LEU A 247
PHE A 231
LEU A  52
ILE A   5
 None
 0.96A 2f78A-5vaeA:
undetectable		 2f78A-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 LEU A 728
PHE A 823
LEU A 794
ILE A 799
TYR A 793
 None
 1.05A 2f78A-5vilA:
undetectable		 2f78A-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 LEU A  60
LEU A  81
ILE A  79
LEU A 120
ILE A 123
 None
 1.21A 2f78A-5wp4A:
undetectable		 2f78A-5wp4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 5 LEU Z  69
LEU Z  40
ILE Z  37
PHE Z  72
LEU Z 186
 None
 1.27A 2f78A-5wtiZ:
undetectable		 2f78A-5wtiZ:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 5 LEU B 321
LEU B 317
LEU B 310
ARG B 311
ILE B 303
 None
 1.09A 2f78A-5xguB:
undetectable		 2f78A-5xguB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 5 LEU A 332
LEU A 333
ILE A 345
PHE A 377
LEU A 298
 None
 1.20A 2f78A-5yx9A:
undetectable		 2f78A-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 377
LEU A 376
ILE A 419
LEU A 331
ILE A 344
 None
 1.08A 2f78A-5zb3A:
undetectable		 2f78A-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 5 LEU A 272
ILE A 207
PHE A 265
LEU A 245
ILE A 285
 None
 1.16A 2f78A-6b2wA:
undetectable		 2f78A-6b2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Homo sapiens) 		no annotation 5 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.90A 2f78A-6d2lA:
undetectable		 2f78A-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 ILE D 137
PHE D  95
LEU D  67
ARG D  68
ILE D  64
 None
 1.21A 2f78A-6f45D:
undetectable		 2f78A-6f45D:
undetectable