SIMILAR PATTERNS OF AMINO ACIDS FOR 2F6D_A_ACRA996

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		4 HIS A 221
ASN A 318
ASP A 276
GLY A 222
 CIT  A 379 (-3.9A)
COA  A 380 (-3.4A)
None
CIT  A 379 ( 3.7A)
 1.04A 2f6dA-1a59A:
0.0		 2f6dA-1a59A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 HIS A 223
ASN A 310
ASP A 269
GLY A 224
 CIT  A1000 (-4.0A)
COA  A3000 (-3.3A)
None
CIT  A1000 (-4.2A)
 0.99A 2f6dA-1aj8A:
0.0		 2f6dA-1aj8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 HIS A 186
ASN A 192
THR A 157
GLY A 185
 ZN  A 293 (-3.3A)
SO4  A 294 ( 4.9A)
None
None
 0.93A 2f6dA-1bf6A:
0.0		 2f6dA-1bf6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fh3 LQH III ALPHA-LIKE
TOXIN

(Leiurus
quinquestriatus) 		PF00537
(Toxin_3) 		4 ASN A  55
ASP A  54
THR A  33
GLY A  32
 None
 0.81A 2f6dA-1fh3A:
undetectable		 2f6dA-1fh3A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 HIS A 105
ASN A  64
THR A 391
GLY A 392
 None
 1.02A 2f6dA-1fi4A:
0.0		 2f6dA-1fi4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gak FERTILIZATION
PROTEIN

(Haliotis
fulgens) 		PF01303
(Egg_lysin) 		4 ASN A  20
ASP A  23
THR A 131
GLY A 130
 None
 0.77A 2f6dA-1gakA:
undetectable		 2f6dA-1gakA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 ASN A  31
THR A 195
GLY A 196
TYR A 197
 None
 0.89A 2f6dA-1gq1A:
0.0		 2f6dA-1gq1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 HIS A  88
ASN A  91
ASP A  92
GLY A 339
 None
None
SWA  A1103 ( 2.4A)
None
 0.82A 2f6dA-1hwwA:
0.3		 2f6dA-1hwwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ASP A  50
THR A  57
GLY A  56
TYR A  97
 None
 1.05A 2f6dA-1idjA:
undetectable		 2f6dA-1idjA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		4 HIS H 199
ASP H 189
THR H 135
GLY H 136
 None
 0.91A 2f6dA-1kigH:
undetectable		 2f6dA-1kigH:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ASN A 666
THR A 603
GLY A 604
TYR A 620
 None
 1.06A 2f6dA-1lf9A:
29.5		 2f6dA-1lf9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 HIS A  57
ASN A  65
THR A 277
GLY A 278
 None
 0.90A 2f6dA-1mlzA:
undetectable		 2f6dA-1mlzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 ASN A 158
ASP A 159
GLY A 328
TYR A 329
 None
 1.05A 2f6dA-1mppA:
undetectable		 2f6dA-1mppA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		4 ARG A 742
THR A 731
GLY A 729
TYR A 728
 None
 1.04A 2f6dA-1pwwA:
undetectable		 2f6dA-1pwwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 HIS A 106
ASN A 274
GLY A 288
TYR A 279
 None
 0.94A 2f6dA-1qh4A:
undetectable		 2f6dA-1qh4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 HIS A 102
ASN A 269
GLY A 283
TYR A 274
 None
 1.02A 2f6dA-1qk1A:
undetectable		 2f6dA-1qk1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 HIS A 105
ASN A 273
GLY A 287
TYR A 278
 None
 0.95A 2f6dA-1u6rA:
undetectable		 2f6dA-1u6rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 HIS A 106
ASN A 274
GLY A 288
TYR A 279
 None
 1.01A 2f6dA-1vrpA:
undetectable		 2f6dA-1vrpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		4 HIS A 244
ASP A 218
THR A 286
GLY A 285
 None
 1.05A 2f6dA-1xp3A:
undetectable		 2f6dA-1xp3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ARG A 203
ASN A 362
ASP A 363
GLY A 200
 None
 0.82A 2f6dA-1z01A:
undetectable		 2f6dA-1z01A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASN A 126
ASP A 127
THR A 114
GLY A 113
 None
None
None
FAD  A 480 (-3.7A)
 0.73A 2f6dA-2a8xA:
undetectable		 2f6dA-2a8xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab9 PRO-SFTI-1

(Helianthus
annuus) 		no annotation 4 ASN A  14
ASP A  13
GLY A   1
TYR A   2
 None
 0.95A 2f6dA-2ab9A:
undetectable		 2f6dA-2ab9A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 ARG A  54
ASP A 319
THR A 200
GLY A  83
 None
 0.96A 2f6dA-2bacA:
undetectable		 2f6dA-2bacA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1w ENDOU PROTEIN

(Xenopus laevis) 		PF09412
(XendoU) 		4 HIS A 272
ASP A 156
THR A 278
GLY A 277
 PO4  A1290 (-3.8A)
None
PO4  A1290 (-3.9A)
PO4  A1290 ( 3.8A)
 1.04A 2f6dA-2c1wA:
undetectable		 2f6dA-2c1wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS A 199
ASP A 189
THR A 135
GLY A 136
 None
DT8  A 700 (-3.5A)
None
None
 0.87A 2f6dA-2ei8A:
undetectable		 2f6dA-2ei8A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 ASP A 312
THR A 288
GLY A 289
TYR A 180
 None
NDP  A 501 (-4.2A)
NDP  A 501 ( 3.7A)
None
 0.95A 2f6dA-2gv8A:
undetectable		 2f6dA-2gv8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		4 HIS A 272
ASN A 369
ASP A 320
GLY A 273
 CMX  A5001 ( 3.7A)
CMX  A5001 (-3.3A)
None
CMX  A5001 ( 3.9A)
 1.00A 2f6dA-2h12A:
undetectable		 2f6dA-2h12A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 ASN A 160
ASP A  61
THR A  48
GLY A  49
 None
 1.03A 2f6dA-2hruA:
undetectable		 2f6dA-2hruA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ASN A 173
ASP A 178
THR A 149
GLY A 148
 None
None
C8E  A1297 ( 4.7A)
None
 0.98A 2f6dA-2o4vA:
undetectable		 2f6dA-2o4vA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ASN A 421
ASP A 396
GLY A 471
TYR A 470
 CSO  A 424 ( 4.2A)
None
CSO  A 424 ( 3.4A)
None
 0.93A 2f6dA-2o7qA:
undetectable		 2f6dA-2o7qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		5 HIS A 211
ASN A 298
ASP A 257
THR A 318
GLY A 212
 FLC  A 401 ( 4.5A)
FLC  A 401 ( 4.0A)
None
None
FLC  A 401 ( 4.0A)
 1.35A 2f6dA-2p2wA:
undetectable		 2f6dA-2p2wA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		4 ARG A 157
ASN A 256
ASP A 254
GLY A 160
 None
PGE  A 406 ( 4.6A)
None
None
 1.05A 2f6dA-2r09A:
undetectable		 2f6dA-2r09A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		5 HIS A 222
ASN A 315
ASP A 269
THR A 337
GLY A 223
 CMC  A 701 ( 3.7A)
CMC  A 701 (-3.0A)
None
None
CMC  A 701 (-3.5A)
 1.30A 2f6dA-2r26A:
undetectable		 2f6dA-2r26A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 4 ARG A 473
ASP A 295
THR A 402
GLY A 401
 None
 1.03A 2f6dA-2vf1A:
undetectable		 2f6dA-2vf1A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr3 CLUMPING FACTOR A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 HIS A 494
ASN A 423
THR A 431
GLY A 493
 None
 1.05A 2f6dA-2vr3A:
undetectable		 2f6dA-2vr3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		4 ARG A 167
HIS A 599
ASN A 143
GLY A 147
 None
 0.87A 2f6dA-2xheA:
undetectable		 2f6dA-2xheA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		4 ASN A 249
THR A  25
GLY A 205
TYR A 236
 None
 1.04A 2f6dA-2z8zA:
undetectable		 2f6dA-2z8zA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		4 HIS A 170
THR A 199
GLY A 200
TYR A 171
 None
 0.89A 2f6dA-2zu0A:
undetectable		 2f6dA-2zu0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayd GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A 214
ASP A 215
THR A 243
GLY A 136
 None
 1.00A 2f6dA-3aydA:
undetectable		 2f6dA-3aydA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		4 ASN A 109
ASP A 133
THR A 128
GLY A 127
 None
None
PO4  A 247 (-3.7A)
PO4  A 247 ( 3.8A)
 0.88A 2f6dA-3bexA:
undetectable		 2f6dA-3bexA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		4 ASN A 148
ASP A 147
THR A 221
GLY A 222
 None
 0.94A 2f6dA-3e0xA:
undetectable		 2f6dA-3e0xA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 ARG B 134
ASN B 110
ASP B 107
GLY A1235
 None
 0.93A 2f6dA-3egwB:
undetectable		 2f6dA-3egwB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3few COLICIN S4

(Escherichia
coli) 		PF01024
(Colicin) 		4 ARG X 280
ASN X 274
THR X 240
GLY X 241
 None
 1.05A 2f6dA-3fewX:
undetectable		 2f6dA-3fewX:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 HIS A 291
THR A 297
GLY A 292
TYR A 319
 U2F  A 547 (-4.0A)
None
None
None
 1.05A 2f6dA-3h4iA:
undetectable		 2f6dA-3h4iA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 HIS A 242
ASN A 330
ASP A 288
GLY A 243
 SIN  A 401 (-4.3A)
None
None
None
 1.06A 2f6dA-3hwkA:
undetectable		 2f6dA-3hwkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq E-CADHERIN
PLAKOGLOBIN

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF01049
(Cadherin_C) 		4 ARG A 572
ASP C 665
THR A 564
GLY A 565
 None
 0.84A 2f6dA-3ifqA:
undetectable		 2f6dA-3ifqA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ASN A 154
ASP A 150
THR A 273
GLY A 272
 None
MG  A 501 (-2.5A)
None
None
 0.84A 2f6dA-3iieA:
undetectable		 2f6dA-3iieA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 HIS X 272
ASP X 145
THR X 274
GLY X 273
 None
 1.01A 2f6dA-3lxuX:
3.8		 2f6dA-3lxuX:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m88 AMOEBIASIN-2

(Entamoeba
histolytica) 		PF09394
(Inhibitor_I42) 		4 ASN A  53
THR A  48
GLY A  49
TYR A  50
 None
 0.94A 2f6dA-3m88A:
undetectable		 2f6dA-3m88A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASN A 279
ASP A 280
THR A 223
GLY A 222
 None
 0.69A 2f6dA-3nqxA:
undetectable		 2f6dA-3nqxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		4 ASN A  68
ASP A  26
GLY A  63
TYR A  64
 None
 0.87A 2f6dA-3p8aA:
undetectable		 2f6dA-3p8aA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASN A 421
ASP A 420
THR A 446
GLY A 447
 None
ACR  A 664 (-2.8A)
None
None
 1.06A 2f6dA-3pocA:
undetectable		 2f6dA-3pocA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 ARG A 189
ASP A 154
THR A 142
GLY A 141
 EDO  A 492 (-3.5A)
EDO  A 492 ( 4.0A)
None
None
 1.01A 2f6dA-3tc9A:
undetectable		 2f6dA-3tc9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		4 ASN A 172
ASP A 341
THR A 252
GLY A 251
 None
 0.89A 2f6dA-3uaqA:
undetectable		 2f6dA-3uaqA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ASN A  44
ASP A  45
THR A   9
GLY A  49
 None
 0.91A 2f6dA-3vf1A:
undetectable		 2f6dA-3vf1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 ASP A 482
THR A 441
GLY A 442
TYR A 443
 None
 0.92A 2f6dA-3vm7A:
undetectable		 2f6dA-3vm7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ARG A 386
ASP A 297
GLY A 258
TYR A 259
 None
 1.05A 2f6dA-4aeeA:
undetectable		 2f6dA-4aeeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 ASP A 491
THR A 476
GLY A 477
TYR A 478
 None
 0.58A 2f6dA-4aqsA:
undetectable		 2f6dA-4aqsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 4 HIS A 249
ASP A   5
THR A 295
GLY A 296
 None
 1.01A 2f6dA-4czxA:
undetectable		 2f6dA-4czxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 ASN A 507
ASP A 508
THR A 475
GLY A 476
 None
 0.88A 2f6dA-4djiA:
undetectable		 2f6dA-4djiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvo LMO2349 PROTEIN

(Listeria
monocytogenes) 		PF00497
(SBP_bac_3) 		4 HIS A 101
ASN A  86
THR A  43
GLY A  42
 CSX  A 704 ( 4.5A)
None
None
None
 1.03A 2f6dA-4gvoA:
undetectable		 2f6dA-4gvoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		4 HIS A  34
ASN A  30
ASP A  23
GLY A 164
 FE  A 202 ( 3.3A)
None
None
None
 1.06A 2f6dA-4n6wA:
undetectable		 2f6dA-4n6wA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ARG A 954
ASN A 320
ASP A 321
GLY A 949
 None
 1.06A 2f6dA-4nmeA:
undetectable		 2f6dA-4nmeA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 ARG A 308
ASN A 215
THR A 334
GLY A 302
 None
 1.02A 2f6dA-4nqyA:
undetectable		 2f6dA-4nqyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 HIS A 223
ASN A 141
ASP A 142
THR A 253
 None
 0.99A 2f6dA-4pmzA:
undetectable		 2f6dA-4pmzA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		4 HIS A 162
ASN A 181
THR A 107
GLY A 121
 None
 1.05A 2f6dA-4yr1A:
undetectable		 2f6dA-4yr1A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 466
ASP A 783
THR A 422
GLY A 423
 ADP  A1103 (-4.1A)
None
ADP  A1103 (-4.0A)
ADP  A1103 (-3.1A)
 0.85A 2f6dA-5b7iA:
undetectable		 2f6dA-5b7iA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd6 TPR-DOMAIN
CONTAINING PROTEIN

(Parabacteroides
distasonis) 		PF17128
(DUF5107) 		4 ASP A 214
THR A 342
GLY A 273
TYR A 266
 None
 0.94A 2f6dA-5cd6A:
undetectable		 2f6dA-5cd6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 ASP A 136
THR A 171
GLY A 170
TYR A 168
 None
 1.06A 2f6dA-5cvvA:
undetectable		 2f6dA-5cvvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ASP A  65
THR A  72
GLY A  69
TYR A  68
 None
 0.95A 2f6dA-5d6bA:
undetectable		 2f6dA-5d6bA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1t TNF
RECEPTOR-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 4 HIS A 321
ASP A 360
THR A 316
GLY A 317
 None
 1.05A 2f6dA-5e1tA:
undetectable		 2f6dA-5e1tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2

(Homo sapiens) 		PF00092
(VWA)
PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		4 ARG A 495
ASN B 260
ASP B 278
GLY B 283
 None
 0.87A 2f6dA-5e6sA:
undetectable		 2f6dA-5e6sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 533
ASP A 534
GLY A 568
TYR A 530
 None
 0.97A 2f6dA-5fp2A:
undetectable		 2f6dA-5fp2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 ARG A 346
HIS A  87
ASP A  57
GLY A  85
 GOL  A 403 (-2.7A)
GOL  A 404 (-4.4A)
GOL  A 403 (-2.9A)
ACT  A 405 ( 4.2A)
 1.03A 2f6dA-5gllA:
undetectable		 2f6dA-5gllA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9p GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A 214
ASP A 215
THR A 243
GLY A 136
 None
 0.94A 2f6dA-5h9pA:
undetectable		 2f6dA-5h9pA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 ARG A 164
ASP A 273
THR A 294
GLY A 293
 None
 0.93A 2f6dA-5ixpA:
undetectable		 2f6dA-5ixpA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 ARG A 385
ASP A 323
THR A 479
GLY A 478
 None
 0.96A 2f6dA-5jvkA:
undetectable		 2f6dA-5jvkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ARG A  68
ASN A 250
ASP A 238
GLY A 110
 None
 0.98A 2f6dA-5k3hA:
undetectable		 2f6dA-5k3hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 4 ASN D 175
ASP D 197
GLY D 201
TYR D 200
 None
None
CL  D 401 (-3.8A)
None
 1.03A 2f6dA-5k59D:
undetectable		 2f6dA-5k59D:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ARG B 704
HIS B  33
ASN B   8
ASP B 652
 None
 1.03A 2f6dA-5ldrB:
undetectable		 2f6dA-5ldrB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1g GAG PROTEIN

(Simian foamy
virus) 		PF03276
(Gag_spuma) 		4 HIS A 383
ASN A 418
THR A 385
GLY A 384
 None
 0.79A 2f6dA-5m1gA:
undetectable		 2f6dA-5m1gA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ASN A 527
ASP A 528
GLY A 568
TYR A 524
 None
 0.98A 2f6dA-5mzsA:
undetectable		 2f6dA-5mzsA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ARG A 410
ASN A 365
ASP A 366
GLY A  83
 None
 0.78A 2f6dA-5n6uA:
undetectable		 2f6dA-5n6uA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 HIS A 337
ASN A 344
ASP A 343
THR A 352
 None
 0.95A 2f6dA-5nagA:
undetectable		 2f6dA-5nagA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfb GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A 214
ASP A 215
THR A 243
GLY A 136
 None
 1.01A 2f6dA-5nfbA:
undetectable		 2f6dA-5nfbA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o63 RESTRICTION
ENDONUCLEASE UBALAI

(unidentified) 		no annotation 4 ARG A 107
ASN A  32
THR A  93
GLY A  36
 None
 0.92A 2f6dA-5o63A:
undetectable		 2f6dA-5o63A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		4 HIS A  57
ASN A  65
THR A 277
GLY A 278
 None
None
LLP  A 274 ( 4.3A)
None
 0.99A 2f6dA-5uc7A:
undetectable		 2f6dA-5uc7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 ASP V 380
THR V 391
GLY V 390
TYR V 392
 None
 1.06A 2f6dA-5vhsV:
undetectable		 2f6dA-5vhsV:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm2 ALCOHOL
DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A  86
ASN A 142
ASP A 141
GLY A 148
 None
 1.05A 2f6dA-5vm2A:
undetectable		 2f6dA-5vm2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wid -

(-) 		no annotation 4 HIS A 120
ASP A 126
GLY A  91
TYR A  90
 None
None
FMN  A 201 ( 3.5A)
FMN  A 201 (-4.8A)
 0.89A 2f6dA-5widA:
undetectable		 2f6dA-5widA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 ARG A 300
ASP A 448
THR A 630
GLY A 629
 None
 0.90A 2f6dA-5xb7A:
undetectable		 2f6dA-5xb7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 HIS A 635
ASP A 903
GLY A 580
TYR A 581
 ADA  A1004 ( 4.1A)
None
None
None
 0.99A 2f6dA-5xqoA:
5.5		 2f6dA-5xqoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 4 ASN F  27
ASP F  20
THR F 414
GLY F 413
 None
 1.05A 2f6dA-5y81F:
undetectable		 2f6dA-5y81F:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 ARG A 275
ASN A 212
ASP A 213
GLY A 281
 None
None
CA  A 802 ( 2.2A)
None
 1.02A 2f6dA-5yl7A:
undetectable		 2f6dA-5yl7A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ARG A 172
ASP A 146
THR A 164
GLY A 165
 None
None
NAD  A 500 (-3.7A)
None
 1.00A 2f6dA-6aphA:
undetectable		 2f6dA-6aphA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 ASN A 807
ASP A 804
THR A 840
GLY A 841
 None
None
SAH  A1102 (-4.1A)
None
 0.96A 2f6dA-6d6yA:
undetectable		 2f6dA-6d6yA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 4 ARG C  21
ASP C  26
GLY C 252
TYR C 253
 None
 1.06A 2f6dA-6fkxC:
undetectable		 2f6dA-6fkxC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 ARG A 170
ASP A 144
THR A 162
GLY A 163
 None
None
NAD  A 502 (-3.7A)
None
 1.02A 2f6dA-6gbnA:
undetectable		 2f6dA-6gbnA:
undetectable