SIMILAR PATTERNS OF AMINO ACIDS FOR 2F38_A_15MA325_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		5 TYR A  24
TRP A  86
LEU A 122
ASN A 167
PRO A 318
 None
None
None
NDP  A1003 (-3.4A)
None
 0.53A 2f38A-1q5mA:
52.2		 2f38A-1q5mA:
77.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 5 ASN P 179
PHE P 129
PHE P 175
PRO P 181
TYR P 250
 None
 1.47A 2f38A-2btvP:
0.0		 2f38A-2btvP:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 TYR A 101
SER A 131
MET A 126
ASN A 133
PHE A 413
 None
 1.42A 2f38A-2e7zA:
1.3		 2f38A-2e7zA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TYR A  24
TRP A  86
MET A 120
LEU A 122
ASN A 167
PRO A 318
 None
None
None
None
NAP  A1001 (-3.1A)
None
 0.55A 2f38A-2fvlA:
52.1		 2f38A-2fvlA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 TRP A  86
MET A 120
LEU A 122
ASN A 167
PRO A 318
 None
None
None
NAP  A   1 (-3.3A)
None
 0.49A 2f38A-2ipfA:
51.0		 2f38A-2ipfA:
71.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 ANTIBODY SCFV
FRAGMENT, HEAVY
CHAIN
ANTIBODY SCFV
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 SER B  50
PHE C  98
PHE B 103
PRO C  44
TYR C  87
 None
 1.37A 2f38A-3ab0B:
0.0		 2f38A-3ab0B:
14.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 TYR A  26
TRP A  89
MET A 123
ASN A 170
PRO A 321
 CI2  A 328 ( 4.0A)
None
None
NAP  A 327 (-3.6A)
None
 0.47A 2f38A-3cavA:
49.0		 2f38A-3cavA:
55.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 5 TRP A  86
SER A 118
PHE A 311
PRO A 318
TYR A 317
 None
CJ2  A 402 ( 3.7A)
None
None
None
 1.39A 2f38A-6f2uA:
52.2		 2f38A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 10 TYR A  24
TRP A  86
SER A 118
MET A 120
LEU A 122
SER A 129
ASN A 167
PHE A 306
PRO A 318
TYR A 319
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
None
None
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
None
None
 0.52A 2f38A-6f2uA:
52.2		 2f38A-6f2uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 10 TYR A  24
TRP A  86
SER A 118
MET A 120
LEU A 122
SER A 129
ASN A 167
PHE A 311
PRO A 318
TYR A 319
 CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
None
None
NAP  A 401 ( 3.3A)
None
None
None
 0.61A 2f38A-6f2uA:
52.2		 2f38A-6f2uA:
100.00