SIMILAR PATTERNS OF AMINO ACIDS FOR 2EZ7_A_DHIA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bol PROTEIN
(RIBONUCLEASE RH)

(Rhizopus niveus) 		PF00445
(Ribonuclease_T2) 		4 TRP A  49
HIS A  46
ASN A  94
GLN A  95
 None
 1.19A 2ez7A-1bolA:
undetectable		 2ez7A-1bolA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 HIS A  19
ASN A 128
GLN A 288
THR A  16
 None
 1.07A 2ez7A-1f0kA:
undetectable		 2ez7A-1f0kA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  92
THR A 200
PRO A 202
 None
AZM  A1400 (-3.2A)
AZM  A1400 (-3.3A)
None
 0.69A 2ez7A-1jd0A:
36.0		 2ez7A-1jd0A:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		4 TRP A   7
GLN A  90
THR A 178
PRO A 180
 None
None
AZI  A 305 ( 4.2A)
None
 0.43A 2ez7A-1kopA:
29.2		 2ez7A-1kopA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 ASN A  62
GLN A  67
THR A 200
PRO A 202
 None
None
AZM  A 400 (-3.6A)
None
 1.34A 2ez7A-1rj6A:
36.9		 2ez7A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  67
THR A 200
PRO A 202
 None
None
AZM  A 400 (-3.6A)
None
 1.20A 2ez7A-1rj6A:
36.9		 2ez7A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  92
THR A 200
PRO A 202
 None
AZM  A 400 (-4.3A)
AZM  A 400 (-3.6A)
None
 0.50A 2ez7A-1rj6A:
36.9		 2ez7A-1rj6A:
37.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 HIS A 153
ASN A 244
THR A 188
PRO A 190
 None
 1.17A 2ez7A-1t9kA:
undetectable		 2ez7A-1t9kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 ASN A 230
GLN A 153
THR A  98
PRO A 103
 None
 1.30A 2ez7A-1yw1A:
undetectable		 2ez7A-1yw1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 TRP A 102
HIS A 122
ASN A 151
GLN A 349
 NO3  A 700 (-3.8A)
None
None
None
 1.47A 2ez7A-2g29A:
undetectable		 2ez7A-2g29A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 HIS B 217
ASN B 219
THR B 114
PRO B 113
 None
 1.23A 2ez7A-2iaeB:
undetectable		 2ez7A-2iaeB:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
HIS A  64
GLN A  92
PRO A 202
 None
 0.70A 2ez7A-2it4A:
40.4		 2ez7A-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 ASN A 207
GLN A  84
THR A 223
PRO A 225
 None
 1.50A 2ez7A-2oq2A:
undetectable		 2ez7A-2oq2A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 HIS A  11
ASN A 293
GLN A  15
PRO A  68
 PO4  A 402 (-3.8A)
None
None
None
 1.44A 2ez7A-2r87A:
undetectable		 2ez7A-2r87A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 ASN B 167
GLN B 239
THR B 161
PRO B 164
 None
 1.23A 2ez7A-2xdqB:
undetectable		 2ez7A-2xdqB:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adp LAMBDA-CRYSTALLIN

(Oryctolagus
cuniculus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 HIS A 145
ASN A 196
GLN A 199
PRO A 149
 NAI  A1001 (-4.6A)
None
None
None
 1.30A 2ez7A-3adpA:
undetectable		 2ez7A-3adpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 TRP A  40
GLN A 161
THR A 261
PRO A 263
 None
 0.39A 2ez7A-3b1bA:
25.1		 2ez7A-3b1bA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   6
ASN A  68
GLN A  93
PRO A 203
 None
None
4MD  A 401 (-3.1A)
4MD  A 401 ( 4.9A)
 0.93A 2ez7A-3da2A:
41.6		 2ez7A-3da2A:
60.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3s LAMBDA-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 HIS A 145
ASN A 196
GLN A 199
PRO A 149
 NAD  A 601 ( 4.5A)
None
None
None
 1.26A 2ez7A-3f3sA:
undetectable		 2ez7A-3f3sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9j MCCB PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		4 ASN A 154
GLN A 158
THR A 290
PRO A 288
 None
APC  A 359 (-3.7A)
None
None
 1.49A 2ez7A-3h9jA:
undetectable		 2ez7A-3h9jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 ASN A 131
GLN A 135
THR A 197
PRO A 200
 None
 1.49A 2ez7A-3jbhA:
undetectable		 2ez7A-3jbhA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 HIS A  99
ASN A  88
THR A  97
PRO A  96
 None
 1.31A 2ez7A-3m0gA:
undetectable		 2ez7A-3m0gA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 HIS A 107
ASN A  96
THR A 105
PRO A 104
 None
None
GOL  A 310 (-4.3A)
None
 1.50A 2ez7A-3m9uA:
undetectable		 2ez7A-3m9uA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ASN A  62
GLN A  67
THR A 200
PRO A 202
 None
None
AZM  A 264 (-3.5A)
None
 1.11A 2ez7A-3ml5A:
42.8		 2ez7A-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  67
THR A 200
PRO A 202
 None
None
AZM  A 264 (-3.5A)
None
 1.13A 2ez7A-3ml5A:
42.8		 2ez7A-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  92
THR A 200
PRO A 202
 None
AZM  A 264 (-4.1A)
AZM  A 264 (-3.5A)
None
 0.29A 2ez7A-3ml5A:
42.8		 2ez7A-3ml5A:
55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
HIS A  64
THR A 200
PRO A 202
 None
None
AZM  A 264 (-3.5A)
None
 1.15A 2ez7A-3ml5A:
42.8		 2ez7A-3ml5A:
55.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 HIS A  96
ASN A  85
THR A  94
PRO A  93
 None
 1.41A 2ez7A-3npkA:
undetectable		 2ez7A-3npkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 HIS A 110
ASN A  99
THR A 108
PRO A 107
 None
 1.41A 2ez7A-3q1oA:
undetectable		 2ez7A-3q1oA:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		4 HIS A 125
GLN A 121
THR A 215
PRO A 217
 ZN  A   1 (-3.3A)
MLT  A   3 (-3.9A)
MLT  A   3 ( 4.3A)
None
 1.13A 2ez7A-3q31A:
24.4		 2ez7A-3q31A:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 HIS A 161
GLN A  69
THR A 113
PRO A 115
 GOL  A 317 (-4.0A)
None
GOL  A 317 ( 4.8A)
None
 1.23A 2ez7A-3rotA:
undetectable		 2ez7A-3rotA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		4 HIS A 109
ASN A  98
THR A 107
PRO A 106
 None
 1.32A 2ez7A-3ucaA:
undetectable		 2ez7A-3ucaA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  92
THR A 199
PRO A 201
 None
 0.39A 2ez7A-3uyqA:
40.5		 2ez7A-3uyqA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		4 ASN A 112
GLN A 114
THR A  58
PRO A  81
 None
 1.04A 2ez7A-3wufA:
undetectable		 2ez7A-3wufA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TRP A 143
HIS A 209
ASN A 174
PRO A 140
 None
GOL  A 601 (-4.1A)
None
None
 1.38A 2ez7A-3wy2A:
undetectable		 2ez7A-3wy2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 HIS A 143
ASN A  96
GLN A  99
PRO A  62
 None
 1.32A 2ez7A-4a0sA:
undetectable		 2ez7A-4a0sA:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		4 TRP A   3
GLN A  87
THR A 175
PRO A 177
 None
AZM  A 302 (-4.4A)
AZM  A 302 (-3.4A)
None
 0.52A 2ez7A-4g7aA:
29.5		 2ez7A-4g7aA:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		4 HIS A 349
ASN A 301
THR A 374
PRO A 371
 None
 1.33A 2ez7A-4jp0A:
undetectable		 2ez7A-4jp0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		4 HIS A 104
ASN A  93
THR A 102
PRO A 101
 None
 1.40A 2ez7A-4kkmA:
undetectable		 2ez7A-4kkmA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		4 HIS A 167
ASN A 258
THR A 202
PRO A 204
 None
 1.17A 2ez7A-4ldqA:
undetectable		 2ez7A-4ldqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		4 TRP A  15
ASN A 160
THR A  28
PRO A  26
 None
 1.20A 2ez7A-4lebA:
undetectable		 2ez7A-4lebA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 HIS A  98
ASN A  87
THR A  96
PRO A  95
 None
 1.43A 2ez7A-4llsA:
undetectable		 2ez7A-4llsA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  64
ASN A  67
GLN A  92
THR A 200
PRO A 202
 None
 0.37A 2ez7A-4qk3A:
43.6		 2ez7A-4qk3A:
95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		4 HIS A 318
ASN A 234
THR A 275
PRO A 274
 None
None
None
GOL  A 502 ( 4.6A)
 1.49A 2ez7A-4ruwA:
undetectable		 2ez7A-4ruwA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 TRP A  26
HIS A  87
GLN A 110
THR A 199
PRO A 201
 None
CL  A 304 ( 4.9A)
CL  A 304 ( 3.7A)
AZM  A 299 (-3.3A)
None
 0.54A 2ez7A-4uovA:
30.8		 2ez7A-4uovA:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur2 TETRACHLOROETHENE
REDUCTIVE
DEHALOGENASE
CATALYTIC SUBUNIT
PCEA

(Sulfurospirillum
multivorans) 		PF13484
(Fer4_16)
PF13486
(Dehalogenase) 		4 ASN A 358
GLN A 364
THR A 345
PRO A 348
 BVQ  A 503 (-3.7A)
BVQ  A 503 (-3.1A)
None
GOL  A 515 (-4.3A)
 1.46A 2ez7A-4ur2A:
undetectable		 2ez7A-4ur2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		4 TRP A 559
HIS A 672
THR A 771
PRO A 770
 None
 1.49A 2ez7A-4v1uA:
undetectable		 2ez7A-4v1uA:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		4 TRP A   3
GLN A  87
THR A 175
PRO A 177
 None
AZM  A 302 (-4.3A)
AZM  A 302 (-3.3A)
None
 0.51A 2ez7A-4x5sA:
29.6		 2ez7A-4x5sA:
38.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 134
GLN A 138
THR A 255
PRO A 257
 None
None
2HP  A 402 (-3.6A)
None
 1.19A 2ez7A-4xixA:
25.8		 2ez7A-4xixA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		4 TRP A  78
GLN A 163
THR A 253
PRO A 255
 None
None
BCT  A 402 ( 4.4A)
None
 0.47A 2ez7A-4xz5A:
29.4		 2ez7A-4xz5A:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 TRP A 254
HIS A 238
GLN A 295
PRO A 259
 None
 1.29A 2ez7A-4zhjA:
undetectable		 2ez7A-4zhjA:
12.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
GLN A  92
THR A 200
PRO A 202
 None
GOL  A 303 (-3.2A)
GOL  A 303 ( 3.5A)
None
 0.53A 2ez7A-5cjfA:
36.2		 2ez7A-5cjfA:
36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 HIS A 110
ASN A  99
THR A 108
PRO A 107
 None
 1.38A 2ez7A-5e8hA:
undetectable		 2ez7A-5e8hA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er7 GAP JUNCTION BETA-2
PROTEIN

(Homo sapiens) 		no annotation 4 TRP B  77
HIS B  73
GLN B 164
THR B 192
 None
 1.28A 2ez7A-5er7B:
undetectable		 2ez7A-5er7B:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 TRP X   4
ASN X  66
GLN X  91
THR X 198
PRO X 200
 None
 0.30A 2ez7A-5eztX:
43.6		 2ez7A-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 HIS A  98
GLN A  94
THR A 182
PRO A 184
 ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
 1.13A 2ez7A-5hpjA:
29.0		 2ez7A-5hpjA:
35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 TRP A  15
GLN A  74
THR A 183
PRO A 185
 None
 1.40A 2ez7A-5hpjA:
29.0		 2ez7A-5hpjA:
35.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		4 TRP A  15
GLN A  94
THR A 183
PRO A 185
 None
 0.45A 2ez7A-5hpjA:
29.0		 2ez7A-5hpjA:
35.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ASN B 103
GLN B 958
THR B 454
PRO B 171
 None
 1.25A 2ez7A-5ip9B:
undetectable		 2ez7A-5ip9B:
13.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 TRP A   5
HIS A  64
GLN A  92
THR A 200
 None
None
EZL  A 302 (-4.3A)
EZL  A 302 (-3.9A)
 0.43A 2ez7A-5jn9A:
33.0		 2ez7A-5jn9A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 TRP A 147
HIS A 150
THR A  96
PRO A  99
 None
 1.28A 2ez7A-5mhfA:
undetectable		 2ez7A-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 TRP A 352
ASN A 300
GLN A 299
PRO A 153
 GOL  A 603 (-3.9A)
None
None
None
 1.32A 2ez7A-5u2oA:
undetectable		 2ez7A-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S24E, PUTATIVE

(Trichomonas
vaginalis) 		PF01282
(Ribosomal_S24e) 		4 ASN Y  14
GLN Y  21
THR Y  84
PRO Y  86
 None
 1.36A 2ez7A-5xyiY:
undetectable		 2ez7A-5xyiY:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 4 HIS A 886
ASN A 771
THR A 225
PRO A 224
 None
 1.47A 2ez7A-5zq6A:
undetectable		 2ez7A-5zq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 4 TRP A  33
GLN A 115
THR A 203
PRO A 205
 None
 0.51A 2ez7A-6ekiA:
29.5		 2ez7A-6ekiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 4 TRP A   5
GLN A  92
THR A 200
PRO A 202
 None
V14  A 302 (-3.8A)
V14  A 302 (-3.5A)
None
 0.44A 2ez7A-6fe1A:
33.4		 2ez7A-6fe1A:
undetectable