SIMILAR PATTERNS OF AMINO ACIDS FOR 2EVA_A_ADNA498

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.55A 2evaA-1k9aA:
27.4		 2evaA-1k9aA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
GLY A 214
VAL A 219
ALA A 230
TYR A 282
SER A 287
LEU A 340
 None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.66A 2evaA-1py5A:
27.1		 2evaA-1py5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
ALA A 230
TYR A 282
SER A 287
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.75A 2evaA-1py5A:
27.1		 2evaA-1py5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  79
VAL A  86
ALA A  99
MET A 147
SER A 154
LEU A 201
ASP A 212
 ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
ATP  A 535 (-2.6A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.80A 2evaA-1s9iA:
14.8		 2evaA-1s9iA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 345
VAL A 352
ALA A 367
MET A 414
ALA A 417
LEU A 468
 STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.63A 2evaA-1u59A:
26.6		 2evaA-1u59A:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
SER A 111
LEU A 158
 None
 0.46A 2evaA-1u5qA:
25.8		 2evaA-1u5qA:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  18
VAL X  25
ALA X  37
TYR X  84
SER X  89
LEU X 137
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.0A)
STU  X 902 (-4.4A)
 0.45A 2evaA-2dq7X:
27.9		 2evaA-2dq7X:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
VAL A  42
ALA A  55
MET A 105
TYR A 107
SER A 111
LEU A 158
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 3.7A)
STU  A 400 (-4.5A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.6A)
 0.47A 2evaA-2gcdA:
25.7		 2evaA-2gcdA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.54A 2evaA-2h8hA:
27.1		 2evaA-2h8hA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  60
VAL A  67
ALA A  80
MET A 129
TYR A 131
ALA A 132
 None
 0.54A 2evaA-2hakA:
19.4		 2evaA-2hakA:
31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 345
GLY A 347
VAL A 352
ALA A 367
MET A 414
ALA A 417
LEU A 468
 ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.54A 2evaA-2ozoA:
25.5		 2evaA-2ozoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 None
 0.91A 2evaA-2psqA:
27.6		 2evaA-2psqA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 GLY A 682
GLY A 684
VAL A 689
ALA A 705
TYR A 755
SER A 760
LEU A 807
 None
 0.98A 2evaA-2r2pA:
27.1		 2evaA-2r2pA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  83
VAL A  90
ALA A 103
MET A 153
TYR A 155
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.60A 2evaA-2v55A:
20.5		 2evaA-2v55A:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  27
VAL A  34
ALA A  47
TYR A  97
SER A 102
LEU A 147
 J60  A1294 ( 4.1A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
None
J60  A1294 (-4.8A)
 0.64A 2evaA-2xikA:
19.6		 2evaA-2xikA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 488
GLY A 490
VAL A 495
ALA A 515
TYR A 566
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
 0.64A 2evaA-3b2tA:
20.1		 2evaA-3b2tA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.42A 2evaA-3b2tA:
20.1		 2evaA-3b2tA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.54A 2evaA-3d7uA:
28.1		 2evaA-3d7uA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 151
VAL A 158
ALA A 169
MET A 220
ALA A 223
LEU A 275
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.7A)
VIN  A6331 (-3.8A)
VIN  A6331 (-4.5A)
 0.51A 2evaA-3dtcA:
27.5		 2evaA-3dtcA:
39.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
VAL A  70
ALA A  83
MET A 132
TYR A 134
ALA A 135
 None
 0.60A 2evaA-3fe3A:
20.9		 2evaA-3fe3A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  60
VAL A  67
ALA A  80
MET A 129
SER A 135
LEU A 186
 STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
STU  A   1 (-3.2A)
STU  A   1 (-4.4A)
 0.61A 2evaA-3fmeA:
18.8		 2evaA-3fmeA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 210
GLY A 212
VAL A 217
ALA A 228
MET A 279
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.76A 2evaA-3g2fA:
27.1		 2evaA-3g2fA:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  60
VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
 None
 0.58A 2evaA-3iecA:
23.0		 2evaA-3iecA:
32.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.66A 2evaA-3lm5A:
24.6		 2evaA-3lm5A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 GLY A 211
GLY A 213
VAL A 218
ALA A 229
TYR A 281
SER A 286
LEU A 339
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.5A)
 0.79A 2evaA-3mdyA:
27.3		 2evaA-3mdyA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 208
GLY A 209
VAL A 216
ALA A 227
TYR A 279
SER A 284
LEU A 337
 LDN  A 600 ( 4.4A)
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.7A)
None
LDN  A 600 (-4.6A)
 0.81A 2evaA-3my0A:
26.1		 2evaA-3my0A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A  37
GLY A  39
VAL A  44
ALA A  57
ALA A 114
LEU A 163
 ANP  A 430 (-3.5A)
ANP  A 430 (-3.0A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-3.9A)
ANP  A 430 (-4.4A)
 0.62A 2evaA-3nieA:
22.5		 2evaA-3nieA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  89
GLY A  91
VAL A  96
ALA A 109
TYR A 161
ALA A 162
LEU A 212
 JOZ  A 361 ( 4.3A)
SO4  A   5 ( 4.4A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
JOZ  A 361 (-3.8A)
None
 0.72A 2evaA-3nuuA:
24.5		 2evaA-3nuuA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLY A 558
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.56A 2evaA-3ppzA:
30.3		 2evaA-3ppzA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 424
GLY A 426
VAL A 431
ALA A 443
TYR A 491
LEU A 543
 PP2  A   1 ( 4.1A)
PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.52A 2evaA-3sxsA:
27.8		 2evaA-3sxsA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.64A 2evaA-3tt0A:
26.5		 2evaA-3tt0A:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 296
VAL A 303
ALA A 315
TYR A 365
SER A 370
LEU A 423
ASP A 434
 None
 0.86A 2evaA-3ulzA:
23.1		 2evaA-3ulzA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  60
VAL A  67
ALA A  80
MET A 129
SER A 135
LEU A 186
ASP A 197
 ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
ANK  A 401 (-3.7A)
ANK  A 401 ( 4.9A)
MG  A 402 ( 2.8A)
 0.77A 2evaA-3vn9A:
23.9		 2evaA-3vn9A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  76
VAL A  83
ALA A  96
MET A 144
SER A 151
LEU A 198
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.59A 2evaA-3wigA:
24.3		 2evaA-3wigA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  84
VAL A  91
ALA A 104
TYR A 156
ALA A 157
LEU A 207
 VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
 0.57A 2evaA-4af3A:
19.6		 2evaA-4af3A:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A  84
VAL A  91
ALA A 104
MET A 154
TYR A 156
LEU A 208
 None
None
EDO  A1420 (-3.4A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.45A 2evaA-4aw2A:
21.2		 2evaA-4aw2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  19
GLY A  20
VAL A  27
ALA A  40
TYR A  91
LEU A 142
 38R  A1000 (-4.7A)
None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
 0.47A 2evaA-4bgqA:
23.4		 2evaA-4bgqA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 215
VAL A 222
ALA A 233
TYR A 285
SER A 290
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.76A 2evaA-4c02A:
26.1		 2evaA-4c02A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 214
GLY A 215
VAL A 222
ALA A 233
TYR A 285
SER A 290
LEU A 343
 TAK  A1507 ( 4.3A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.6A)
None
TAK  A1507 (-4.7A)
 0.66A 2evaA-4c02A:
26.1		 2evaA-4c02A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 GLY A 247
VAL A 254
ALA A 267
TYR A 320
ALA A 321
LEU A 371
 None
 0.39A 2evaA-4c0tA:
22.3		 2evaA-4c0tA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 666
VAL A 671
ALA A 684
MET A 737
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.53A 2evaA-4crsA:
23.2		 2evaA-4crsA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		6 GLY A  17
VAL A  24
ALA A  37
MET A  87
TYR A  89
LEU A 140
 ANP  A 300 ( 4.4A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.6A)
ANP  A 300 (-4.3A)
ANP  A 300 (-4.7A)
 0.64A 2evaA-4eqmA:
23.7		 2evaA-4eqmA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  65
VAL A  72
ALA A  88
MET A 134
TYR A 136
LEU A 184
 ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 ( 3.9A)
ADP  A 601 (-4.1A)
ADP  A 601 ( 4.9A)
 0.54A 2evaA-4f99A:
21.8		 2evaA-4f99A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 GLY A 328
GLY A 330
VAL A 335
ALA A 348
MET A 395
LEU A 447
 ANP  A1001 (-4.4A)
ANP  A1001 (-3.2A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-4.8A)
ANP  A1001 (-4.7A)
 0.58A 2evaA-4fieA:
25.2		 2evaA-4fieA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 378
GLY A 380
VAL A 385
ALA A 400
MET A 448
ALA A 451
LEU A 501
 ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.61A 2evaA-4fl3A:
26.1		 2evaA-4fl3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 378
VAL A 385
ALA A 400
MET A 448
ALA A 451
LEU A 501
ASP A 512
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.70A 2evaA-4fl3A:
26.1		 2evaA-4fl3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 856
GLY A 858
VAL A 863
ALA A 880
MET A 929
SER A 936
LEU A 983
 IZA  A2001 ( 4.9A)
IZA  A2001 ( 3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
None
IZA  A2001 ( 4.7A)
 0.70A 2evaA-4gl9A:
26.7		 2evaA-4gl9A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 856
GLY A 858
VAL A 863
ALA A 880
TYR A 931
SER A 936
LEU A 983
 IZA  A2001 ( 4.9A)
IZA  A2001 ( 3.7A)
None
IZA  A2001 (-3.4A)
None
None
IZA  A2001 ( 4.7A)
 0.68A 2evaA-4gl9A:
26.7		 2evaA-4gl9A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 157
VAL A 164
ALA A 177
MET A 227
TYR A 229
ALA A 230
ASP A 292
 GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-3.8A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
0XZ  A 501 ( 3.4A)
 0.53A 2evaA-4gv1A:
23.0		 2evaA-4gv1A:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 829
VAL A 836
ALA A 853
MET A 902
TYR A 904
LEU A 956
 19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
 0.32A 2evaA-4hviA:
27.0		 2evaA-4hviA:
26.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 133
GLY A 135
VAL A 140
ALA A 156
ALA A 208
SER A 212
LEU A 259
 1G0  A 401 ( 4.2A)
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.64A 2evaA-4id7A:
26.1		 2evaA-4id7A:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 407
GLY A 409
VAL A 414
ALA A 427
MET A 469
LEU A 522
ASP A 534
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.90A 2evaA-4idtA:
25.9		 2evaA-4idtA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 407
GLY A 409
VAL A 414
ALA A 427
MET A 469
SER A 476
LEU A 522
 T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 (-3.8A)
T28  A 701 (-3.9A)
 0.74A 2evaA-4idtA:
25.9		 2evaA-4idtA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		7 GLY A 259
GLY A 261
VAL A 266
ALA A 279
MET A 356
ALA A 359
LEU A 416
 ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 (-3.5A)
ANP  A 601 ( 4.9A)
 0.75A 2evaA-4jrnA:
18.2		 2evaA-4jrnA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
ASP A 404
 0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.75A 2evaA-4k11A:
27.2		 2evaA-4k11A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 479
VAL A 486
ALA A 506
TYR A 557
ALA A 558
LEU A 624
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
 0.49A 2evaA-4k33A:
27.5		 2evaA-4k33A:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A  42
GLY A  43
GLY A  45
VAL A  50
ALA A  61
MET A 104
TYR A 106
ALA A 107
SER A 111
LEU A 163
 1UL  A 501 (-4.1A)
1UL  A 501 ( 4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
None
1UL  A 501 (-4.3A)
 0.54A 2evaA-4l52A:
45.7		 2evaA-4l52A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  34
VAL A  41
ALA A  54
MET A  99
TYR A 101
SER A 106
LEU A 153
 None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-2.7A)
GOL  A 404 ( 4.9A)
None
GOL  A 403 ( 4.4A)
 0.69A 2evaA-4lg4A:
17.8		 2evaA-4lg4A:
29.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.52A 2evaA-4lggA:
26.6		 2evaA-4lggA:
30.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  28
GLY A  29
VAL A  36
ALA A  49
SER A 102
LEU A 150
ASP A 161
 ANP  A 401 (-4.7A)
ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.6A)
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.77A 2evaA-4m69A:
26.7		 2evaA-4m69A:
29.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY B  31
GLY B  33
VAL B  38
ALA B  51
MET B  99
TYR B 101
SER B 106
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-3.4A)
ADP  B 500 (-4.7A)
 0.76A 2evaA-4o27B:
19.2		 2evaA-4o27B:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 904
GLY A 906
VAL A 911
ALA A 928
MET A 978
TYR A 980
SER A 985
LEU A1030
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
 0.66A 2evaA-4oliA:
26.3		 2evaA-4oliA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 GLY A  25
GLY A  27
VAL A  32
ALA A  45
MET A  95
TYR A  97
LEU A 148
 STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.72A 2evaA-4rewA:
23.8		 2evaA-4rewA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 151
GLY A 153
VAL A 158
ALA A 169
ALA A 223
LEU A 275
ASP A 294
 None
 0.74A 2evaA-4uy9A:
27.6		 2evaA-4uy9A:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 GLY A 105
GLY A 107
VAL A 112
ALA A 125
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.85A 2evaA-4wb7A:
24.2		 2evaA-4wb7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		6 GLY A 328
GLY A 330
VAL A 335
ALA A 348
MET A 395
LEU A 447
 ATP  A 601 ( 4.1A)
ATP  A 601 (-3.4A)
ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 (-4.3A)
None
 0.56A 2evaA-4xbrA:
17.7		 2evaA-4xbrA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 409
GLY A 411
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 None
 0.57A 2evaA-4xi2A:
19.8		 2evaA-4xi2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 GLY A 409
GLY A 411
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 ( 3.5A)
746  A 702 (-3.0A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.45A 2evaA-4y93A:
27.1		 2evaA-4y93A:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 470
VAL A 477
ALA A 488
TYR A 541
SER A 546
LEU A 595
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-4.4A)
 0.58A 2evaA-4yffA:
27.3		 2evaA-4yffA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.67A 2evaA-5a46A:
26.2		 2evaA-5a46A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.69A 2evaA-5ci7A:
24.2		 2evaA-5ci7A:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  31
GLY A  32
GLY A  34
VAL A  39
ALA A  52
SER A 112
LEU A 160
ASP A 171
 VAL  A  31 (-0.6A)
GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
SER  A 112 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.72A 2evaA-5d7aA:
26.3		 2evaA-5d7aA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 250
GLY A 251
GLY A 253
VAL A 258
ALA A 275
LEU A 386
 STU  A 601 (-3.9A)
STU  A 601 (-2.9A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-3.9A)
 0.65A 2evaA-5e8yA:
26.6		 2evaA-5e8yA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
VAL A  70
ALA A  83
TYR A 134
ALA A 135
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
 0.57A 2evaA-5es1A:
23.3		 2evaA-5es1A:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 904
GLY A 906
VAL A 911
MET A 978
TYR A 980
SER A 985
LEU A1030
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
 0.73A 2evaA-5f1zA:
27.0		 2evaA-5f1zA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
SER A 985
LEU A1030
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
 0.44A 2evaA-5f1zA:
27.0		 2evaA-5f1zA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
SER A 811
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 ( 4.7A)
PP1  A2012 (-4.6A)
 0.48A 2evaA-5fm2A:
27.6		 2evaA-5fm2A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A  87
VAL A  94
ALA A 105
TYR A 150
SER A 155
LEU A 215
 None
 0.62A 2evaA-5gz8A:
19.3		 2evaA-5gz8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		6 GLY A  86
VAL A  93
ALA A 104
TYR A 149
SER A 154
LEU A 214
 ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.2A)
ADP  A 401 (-4.4A)
 0.47A 2evaA-5gzaA:
20.5		 2evaA-5gzaA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  27
GLY A  28
VAL A  35
ALA A  50
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 (-4.7A)
6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.63A 2evaA-5idnA:
14.1		 2evaA-5idnA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  23
GLY A  25
VAL A  30
ALA A  43
MET A  93
TYR A  95
 STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
 0.46A 2evaA-5isoA:
24.2		 2evaA-5isoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 GLY A  23
GLY A  25
VAL A  30
ALA A  43
TYR A  95
LEU A 146
 STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.62A 2evaA-5isoA:
24.2		 2evaA-5isoA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
GLY A  25
VAL A  30
ALA A  43
MET A  90
LEU A 143
ASP A 154
 None
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.89A 2evaA-5j5tA:
23.7		 2evaA-5j5tA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 277
VAL A 284
ALA A 297
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.43A 2evaA-5kbrA:
19.0		 2evaA-5kbrA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 6 GLY A  18
GLY A  20
VAL A  25
ALA A  38
TYR A  88
LEU A 139
 7LV  A 401 ( 3.9A)
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
 0.64A 2evaA-5tvtA:
23.5		 2evaA-5tvtA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  99
VAL A 106
ALA A 119
MET A 169
TYR A 171
LEU A 221
 None
 0.40A 2evaA-5u7qA:
21.1		 2evaA-5u7qA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 219
GLY A 221
VAL A 226
ALA A 239
TYR A 291
SER A 296
 8X7  A 501 ( 3.8A)
8X7  A 501 (-3.4A)
8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-4.2A)
None
 0.55A 2evaA-5vdkA:
16.1		 2evaA-5vdkA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 GLY A 328
GLY A 330
VAL A 335
ALA A 348
MET A 395
LEU A 447
ASP A 458
 M77  A 601 (-3.4A)
M77  A 601 (-2.6A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 0.64A 2evaA-5vefA:
25.7		 2evaA-5vefA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 GLY A 687
GLY A 689
VAL A 694
ALA A 707
MET A 754
SER A 761
LEU A 810
 9E1  A1001 ( 3.4A)
9E1  A1001 (-2.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 ( 3.9A)
9E1  A1001 (-4.5A)
 0.97A 2evaA-5vilA:
7.0		 2evaA-5vilA:
16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 GLY A  27
VAL A  32
ALA A  45
TYR A  97
SER A 102
LEU A 153
 None
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 (-4.6A)
 0.60A 2evaA-5w5jA:
21.7		 2evaA-5w5jA:
31.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 7 VAL A  28
GLY A  29
GLY A  34
VAL A  36
ALA A  49
MET A  96
TYR A  98
 VX6  A 402 ( 4.2A)
VX6  A 402 ( 4.2A)
None
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
VX6  A 402 (-4.3A)
 1.40A 2evaA-5wnmA:
28.4		 2evaA-5wnmA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 8 VAL A  28
GLY A  29
VAL A  36
ALA A  49
MET A  96
TYR A  98
SER A 103
LEU A 150
 VX6  A 402 ( 4.2A)
VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
VX6  A 402 (-4.3A)
VX6  A 402 ( 4.7A)
VX6  A 402 (-4.4A)
 0.68A 2evaA-5wnmA:
28.4		 2evaA-5wnmA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
VAL A 899
ALA A 917
TYR A 965
LEU A1017
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.62A 2evaA-5wnoA:
26.0		 2evaA-5wnoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 8 GLY A  76
GLY A  78
VAL A  83
ALA A  95
TYR A 143
ALA A 144
SER A 148
LEU A 206
 ANP  A1000 ( 3.8A)
ANP  A1000 (-3.3A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-4.3A)
ANP  A1000 (-3.5A)
ANP  A1000 ( 4.4A)
ANP  A1000 (-4.5A)
 0.65A 2evaA-5xd6A:
23.7		 2evaA-5xd6A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 GLY A  34
VAL A  41
ALA A  54
MET A  99
TYR A 101
SER A 106
LEU A 153
 ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.5A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-2.4A)
ANP  A 501 (-4.6A)
 0.69A 2evaA-6ao5A:
23.7		 2evaA-6ao5A:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 VAL A  41
ALA A  54
MET A  99
TYR A 101
SER A 106
LEU A 153
ASP A 164
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.5A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-2.4A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 0.87A 2evaA-6ao5A:
23.7		 2evaA-6ao5A:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 GLY A 882
GLY A 884
VAL A 889
ALA A 906
MET A 956
SER A 963
LEU A1010
 ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.75A 2evaA-6c7yA:
26.6		 2evaA-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 GLY A  67
VAL A  74
ALA A  87
MET A 136
TYR A 138
ALA A 139
LEU A 189
 None
 0.66A 2evaA-6c9dA:
22.7		 2evaA-6c9dA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 GLY A 193
VAL A 200
ALA A 211
TYR A 264
SER A 269
LEU A 318
 CJT  A 502 ( 3.9A)
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
 0.48A 2evaA-6f3dA:
24.8		 2evaA-6f3dA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 8 GLY A 731
GLY A 733
VAL A 738
ALA A 756
TYR A 806
ALA A 807
SER A 811
LEU A 881
 ADN  A1104 ( 3.9A)
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.50A 2evaA-6fekA:
27.5		 2evaA-6fekA:
14.33